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What are the side effects of labetalol. Labetalol Side Effects: Understanding Common and Serious Reactions

What are the common side effects of labetalol. How can patients manage these side effects. When should patients seek medical attention for labetalol side effects. What are the signs of a serious allergic reaction to labetalol.

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Common Side Effects of Labetalol: What to Expect

Labetalol, like many medications, can cause side effects in some individuals. While not everyone experiences these effects, it’s essential to be aware of potential reactions. Common side effects occur in more than 1 in 100 people and are typically mild, often improving as the body adjusts to the medication.

Drowsiness and Dizziness

Feeling sleepy, dizzy, or weak is a frequent side effect of labetalol. To manage these symptoms:

  • Stop activities and sit or lie down when feeling dizzy
  • Avoid driving, cycling, or operating machinery
  • Refrain from alcohol consumption
  • Consult a doctor if dizziness persists for over a week

Headaches

Headaches may occur when taking labetalol. To alleviate this side effect:

  • Rest and stay hydrated
  • Limit alcohol intake
  • Use over-the-counter painkillers as recommended by a pharmacist
  • Seek medical advice if headaches are severe or last longer than a week

Cold Extremities

Cold fingers or toes can be a side effect of labetalol. To improve circulation:

  • Warm hands and feet under running water
  • Massage and wiggle fingers and toes
  • Avoid smoking and caffeine
  • Wear warm mittens and socks
  • Avoid tight accessories that may restrict blood flow

Gastrointestinal Side Effects: Nausea, Vomiting, and Diarrhea

Labetalol can cause various gastrointestinal issues. Here’s how to manage these side effects:

Nausea and Vomiting

  • Stick to simple, non-spicy meals
  • Take labetalol after eating
  • Stay hydrated with water or clear fluids
  • Sip fluids slowly if vomiting occurs
  • Consult a healthcare professional before using anti-nausea medications

For those taking contraceptive pills, vomiting may affect their effectiveness. Check the pill packet for guidance.

Diarrhea

  • Drink plenty of fluids to prevent dehydration
  • Avoid self-medicating without consulting a healthcare provider
  • Be aware that severe diarrhea may affect contraceptive pill effectiveness

Stomach Pain

To alleviate stomach discomfort:

  • Rest and relax
  • Eat smaller, more frequent meals
  • Apply a heat pad or covered hot water bottle to the stomach
  • Seek medical advice if pain is severe or persistent

Recognizing Serious Side Effects of Labetalol

While less common, some individuals may experience serious side effects when taking labetalol. It’s crucial to recognize these symptoms and seek immediate medical attention when necessary.

Heart and Lung Problems

Contact a doctor or call emergency services if you experience:

  • Shortness of breath with worsening cough during exercise
  • Swollen ankles or legs
  • Irregular heartbeat
  • Wheezing or chest tightness

Liver Issues

Be alert for signs of liver problems, such as:

  • Yellowing of the eyes or skin (jaundice)
  • Pale stools
  • Dark urine

Blood Disorders

Seek medical advice if you notice:

  • Unexplained bruising
  • Increased tendency to bruise easily

These symptoms may indicate low platelet counts (thrombocytopenia).

Chest Pain: A Medical Emergency

Chest pain while taking labetalol requires immediate medical attention. Call emergency services immediately if you experience chest pain, as it could be a sign of a heart attack.

Allergic Reactions to Labetalol: Recognizing Anaphylaxis

Although rare, labetalol can cause severe allergic reactions (anaphylaxis). Seek emergency medical care if you develop:

  • Skin rash (itchy, red, swollen, blistered, or peeling)
  • Wheezing
  • Chest or throat tightness
  • Difficulty breathing or speaking
  • Swelling of the mouth, face, lips, tongue, or throat

Anaphylaxis is a medical emergency requiring immediate hospital treatment.

Managing Side Effects: When to Consult a Healthcare Provider

While many side effects of labetalol are mild and resolve on their own, it’s important to know when to seek medical advice. Consult your doctor or pharmacist if:

  • Side effects persist for more than a few days
  • Symptoms become bothersome or interfere with daily activities
  • You experience any unusual or severe reactions

Healthcare providers can offer guidance on managing side effects or adjusting your treatment plan if necessary.

Understanding Labetalol’s Impact on Daily Life

Taking labetalol may require some lifestyle adjustments to manage side effects effectively. Consider the following aspects:

Work and Daily Activities

Due to potential drowsiness and dizziness:

  • Avoid operating heavy machinery or driving until you know how labetalol affects you
  • Inform your employer if your job involves potentially dangerous activities
  • Plan rest periods throughout the day if fatigue is an issue

Exercise and Physical Activity

Labetalol can affect your body’s response to exercise:

  • Start physical activities slowly and gradually increase intensity
  • Be aware of potential dizziness or weakness during workouts
  • Stay hydrated and take breaks as needed
  • Consult your doctor about safe exercise routines while on labetalol

Diet and Nutrition

To minimize gastrointestinal side effects:

  • Eat smaller, more frequent meals
  • Avoid spicy or rich foods if they trigger nausea
  • Stay hydrated with water and clear fluids
  • Consider keeping a food diary to identify any trigger foods

Is labetalol safe to take during pregnancy or while breastfeeding? Consult your healthcare provider for personalized advice, as the benefits and risks must be carefully weighed in these situations.

Long-term Use of Labetalol: What to Consider

For individuals prescribed labetalol for extended periods, it’s important to be aware of potential long-term considerations:

Regular Monitoring

Your healthcare provider may recommend:

  • Periodic blood tests to check liver function and blood counts
  • Regular blood pressure monitoring
  • Assessments of kidney function

Potential Drug Interactions

Labetalol can interact with various medications. Always inform your healthcare provider about:

  • All prescription medications you’re taking
  • Over-the-counter drugs and supplements
  • Herbal remedies or alternative treatments

Lifestyle Modifications

In addition to medication, your doctor may recommend lifestyle changes to manage your condition:

  • Maintaining a healthy diet low in sodium
  • Regular exercise appropriate for your condition
  • Stress management techniques
  • Limiting alcohol consumption
  • Quitting smoking if applicable

Can labetalol be safely discontinued? Never stop taking labetalol abruptly without medical supervision. Your doctor will provide a tapering schedule if the medication needs to be discontinued.

Alternative Treatments and Combination Therapy

For some individuals, labetalol may be prescribed as part of a combination therapy or as an alternative to other medications. Understanding your options can help you make informed decisions about your treatment plan.

Combination Therapies

Labetalol may be used in conjunction with other medications to manage hypertension or related conditions. Common combinations include:

  • Diuretics to help reduce fluid retention
  • Calcium channel blockers for additional blood pressure control
  • ACE inhibitors or ARBs for comprehensive cardiovascular protection

Alternative Medications

If labetalol is not suitable or causes intolerable side effects, your doctor may consider alternative treatments such as:

  • Other beta-blockers with different selectivity profiles
  • ACE inhibitors or ARBs as primary treatments
  • Calcium channel blockers for blood pressure management
  • Alpha-blockers for specific conditions

How do healthcare providers determine the most appropriate treatment plan? Factors such as your medical history, current health status, potential drug interactions, and individual response to medications all play a role in treatment decisions.

Empowering Patients: Self-monitoring and Communication

Taking an active role in your treatment can help optimize the benefits of labetalol while minimizing side effects. Consider the following strategies:

Self-monitoring Techniques

  • Keep a symptom diary to track side effects and their severity
  • Monitor your blood pressure regularly at home if recommended by your doctor
  • Note any changes in your overall health or well-being

Effective Communication with Healthcare Providers

To ensure the best possible care:

  • Prepare a list of questions or concerns before medical appointments
  • Report any new symptoms or side effects promptly
  • Discuss any challenges in adhering to your medication regimen
  • Be honest about lifestyle factors that may impact your treatment

Patient Support Resources

Utilize available resources to enhance your understanding and management of labetalol treatment:

  • Patient education materials provided by your healthcare team
  • Support groups for individuals with similar conditions
  • Reliable online resources recommended by your healthcare provider
  • Pharmacy consultations for medication-related questions

How can patients become more proactive in managing their health while taking labetalol? By staying informed, maintaining open communication with healthcare providers, and actively participating in treatment decisions, patients can play a crucial role in optimizing their care and overall well-being.

Side effects of labetalol – NHS

Like all medicines, labetalol can cause side effects in some people, but many people have no side effects or only minor ones.

Side effects often improve as your body gets used to the medicine.

Common side effects

These common side effects of labetalol happen in more than 1 in 100 people. They’re usually mild and go away by themselves. There are things you can do to help cope with them:

Feeling sleepy, dizzy or weak

If labetalol makes you feel dizzy or weak, stop what you’re doing and sit or lie down until you feel better. Do not drive, cycle or use tools or machinery if you’re feeling sleepy or dizzy. Do not drink alcohol as it will make you feel worse.

Talk to your doctor if you feel dizzy all the time or this side effect lasts longer than a week.

Headaches

Make sure you rest and drink plenty of fluids. Do not drink too much alcohol. Ask your pharmacist to recommend a painkiller.

Headaches usually go away after the first week of taking labetalol. Talk to your doctor if the headaches last longer than a week or are severe.

Cold fingers or toes

Put your hands or feet under warm running water, massage them and wiggle your fingers and toes. Do not smoke or have drinks with caffeine in, as this can make your blood vessels narrower and further restrict blood flow to your hands and feet. Try wearing mittens (they’re warmer than gloves) and warm socks. Do not wear tight watches or bracelets.

Feeling sick or being sick (nausea or vomiting)

Stick to simple meals and do not eat rich or spicy food. It might help to take your labetalol after a meal or snack. Drink plenty of fluids, such as water or squash, to avoid dehydration. Take small, frequent sips if you are being sick. Signs of dehydration include peeing less than usual or having dark, strong-smelling pee.

Do not take any other medicines to treat vomiting without speaking to a pharmacist or doctor.

If you take contraceptive pills and you’re being sick, your contraception may not protect you from pregnancy. Check the pill packet to find out what to do.

Diarrhoea

Drink lots of fluids, such as water or squash, to avoid dehydration. Signs of dehydration include peeing less than usual or having dark, strong-smelling pee.

Do not take any other medicines to treat diarrhoea without speaking to a pharmacist or doctor.

If you take contraceptive pills and you have severe diarrhoea for more than 24 hours, your contraception may not protect you from pregnancy. Check the pill packet to find out what to do.

Stomach pain

Try to rest and relax. It can help to eat and drink slowly and have smaller and more frequent meals. Putting a heat pad or covered hot water bottle on your stomach may also help. If you are in a lot of pain, speak to your pharmacist or doctor.

Talk to your doctor or pharmacist if any of these side effects bother you or last more than a few days.

Serious side effects

It does not happen often, but some people have serious side effects when taking labetalol.

Tell a doctor or call 111 now if:

  • you have shortness of breath with a cough that gets worse when you exercise (like walking up stairs), swollen ankles or legs, or an irregular heartbeat – these are signs of heart problems
  • you have shortness of breath, wheezing and tightening of the chest – these can be signs of lung problems
  • the whites of your eyes turn yellow, or your skin turns yellow although this may be less noticeable on brown or black skin, or you have pale poo or dark pee – these can be signs of liver problems
  • you get unexplained bruising, or you bruise more easily than usual – these can be signs of low numbers of platelets in your blood (thrombocytopenia)

Immediate action required: Call 999 now if:

  • you get chest pain

Chest pain is a possible sign of a heart attack and needs to be checked out as soon as possible.

Serious allergic reaction

In rare cases, labetalol may cause a serious allergic reaction (anaphylaxis).

Immediate action required: Call 999 or go to A&E now if:

  • you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
  • you’re wheezing
  • you get tightness in the chest or throat
  • you have trouble breathing or talking
  • your mouth, face, lips, tongue or throat start swelling

You could be having a serious allergic reaction and may need immediate treatment in hospital.

Other side effects

These are not all the side effects of labetalol. For a full list, see the leaflet inside your medicine packet.

Information:

You can report any suspected side effect using the Yellow Card safety scheme.

Visit Yellow Card for further information.

Page last reviewed: 7 March 2022

Next review due: 7 March 2025

Labetalol: MedlinePlus Drug Information


pronounced as (la bet’ a lole)

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  • Why is this medication prescribed?
  • How should this medicine be used?
  • Other uses for this medicine
  • What special precautions should I follow?
  • What special dietary instructions should I follow?
  • What should I do if I forget a dose?
  • What side effects can this medication cause?
  • What should I know about storage and disposal of this medication?
  • In case of emergency/overdose
  • What other information should I know?
  • Brand names
  • Brand names of combination products

Labetalol is used to treat high blood pressure. Labetalol is in a class of medications called beta blockers. It works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure.

High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.

Labetalol comes as a tablet to take by mouth. It usually is taken two or three times a day. To help you remember to take labetalol, take it around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take labetalol exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Labetalol controls high blood pressure but does not cure it. Continue to take labetalol even if you feel well. Do not stop taking labetalol without talking to your doctor. If you suddenly stop taking labetalol, you may experience serious heart problems such as angina (chest pain) or heart attack.

Labetalol is also used sometimes to treat angina (chest pain) and to treat patients with tetanus. Talk to your doctor about the possible risks of using this medication for your condition.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking labetalol,

  • tell your doctor and pharmacist if you are allergic to labetalol, any other medications, or any ingredients in labetalol tablets. Ask your pharmacist for a list of the ingredients.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: medications for high blood pressure or heart disease; cimetidine; nitroglycerin; and medications for asthma, headaches, allergies, colds, or pain.
  • tell your doctor if you have or have ever had heart, kidney, or liver disease; asthma or other lung diseases; severe allergies; diabetes; or pheochromocytoma (a tumor that develops on a gland near the kidneys and may cause high blood pressure and fast heartbeat).
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking labetalol, call your doctor.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking labetalol.
  • you should know that this medication may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.
  • remember that alcohol can add to the drowsiness caused by this medication.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Labetalol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • dizziness
  • tingling scalp or skin
  • lightheadedness
  • excessive tiredness
  • headache
  • upset stomach
  • stuffy nose

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:

  • shortness of breath or wheezing
  • swelling of the feet and lower legs
  • sudden weight gain
  • chest pain

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.

  • Normodyne®
  • Trandate®
  • Normozide® (containing Labetalol, Hydrochlorothiazide)
  • Trandate HCT® (containing Labetalol, Hydrochlorothiazide)

This branded product is no longer on the market. Generic alternatives may be available.

Last Revised – 01/15/2018

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Labetalol – instructions for use

Labetalol

Instruction:

  • Pharmacological action
  • Readings
  • Contraindications
  • With care
  • Pregnancy and breastfeeding
  • Dosage and Administration
  • Side effects
  • Special instructions
  • Classification

Pharmacological action

Labetalol is a β-adrenergic blocker, it simultaneously has α 1 -adrenergic blocking effect.

The combination of β-adrenergic blocking and peripheral vasodilatory action provides a reliable antihypertensive effect. The drug does not significantly affect the amount of cardiac output and heart rate.

Labetalol is used to lower blood pressure in various degrees of hypertension. Unlike conventional β-blockers, it has a rapid antihypertensive effect.

Labetalol is rapidly absorbed when taken orally. The plasma half-life is approximately 4 hours. It is excreted from the body mainly in the urine in the form of inactive metabolites.

Indications

Adults: arterial hypertension, hypertensive crisis.

Children: an experimental treatment for arterial hypertension.

Contraindications

Hypersensitivity to labetalol.

Labetalol is contraindicated in patients with severe heart failure, atrioventricular blockade, although in recent years there have been data on the beneficial effect of intravenous administration of labetalol on systemic, intracardiac and regional hemodynamics in patients in the early stages of myocardial infarction.

Precautions

Bronchial asthma.

Pregnancy and lactation

FDA fetal category C.

Labetalol crosses the placental barrier.

Dosage and Administration

Children

By mouth: Initial dose 3-4 mg/kg/day in 2 divided doses, maximum dose 40 mg/kg/day.

IV: 0.3–1 mg/kg bolus, for hypertensive crises infusion 0.4–1 mg/kg/h, maximum dose 3 mg/kg/h.

Adults

By mouth: Initial dose 100 mg twice daily, increased by 100 mg daily if necessary, at intervals of 2 to 3 days. A dose of 200-400 mg 2 times a day is usually effective. The maximum dose is 2.4 g / day.

IV bolus: 20 mg or 200 mcg/kg over 2 minutes; if necessary, 40–80 mg is administered every 10 minutes; maximum dose 300 mg.

Intravenous infusion: initial dose of 2 mg/min, gradually increasing if necessary.

Side effects

Headache, nausea, constipation or diarrhea, feeling tired, itchy skin.

Special instructions

Intravenous administration is carried out in a hospital in the “lying” position (due to the rapid and significant decrease in blood pressure).

Classification

  • ATX

    C07AG01

  • Pharmacological group

    Alpha and beta blockers

  • FDA pregnancy category

    C
    (risk not excluded)

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Find out more about the active ingredient Labetalol:

  • INN
  • Reviews
  • Questions (1)
  • Latin name
  • Chemical formula

Information about the active substance Labetalol is intended for medical and pharmaceutical professionals, for reference purposes only. The instructions are not intended to replace professional medical advice, diagnosis or treatment. The information contained here may change over time. The most accurate information on the use of drugs containing the active substance Labetalol is contained in the manufacturer’s instructions attached to the package.

Labetalol: generic, uses, side effects, dosage, interactions, warnings

Medicines and vitamins

  • Brand Name: N/A
  • Drug class: N/A
  • Medical and pharmaceutical editor: Sarfaroy Khan, BHMS, PGD Health Operations
  • Usage

    • What is labetalol and how does it work?
  • Side effects

    • What side effects are associated with the use of labetalol?
  • Dosages

    • What are the dosages of labetalol?
  • Drug Interactions

    • What other drugs interact with labetalol?
  • Warnings and Precautions

    • What are the warnings and precautions for labetalol?

What is labetalol and how does it work?

labetalol is a prescription medicine used to treat the symptoms of Hypertension (high blood pressure) as well as Hypertension Emergency.

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  • Labetalol is available under the following brand names: Deal

What side effects are associated with the use of labetalol?

Common side effects of labetalol include:

  • dizziness,
  • drowsiness,
  • fatigue,
  • nausea,
  • vomiting,
  • sudden heat,
  • reddening of the skin,
  • sweating,
  • numbness and
  • tingling in the scalp

Serious side effects of labetalol include:

  • hives,
  • shortness of breath,
  • swelling of the face, lips, tongue or throat,
  • severe dizziness,
  • dizziness,
  • slow heart rate,
  • weak pulse,
  • fainting,
  • slow breathing or breathing that may stop,
  • shortness of breath (even with mild exertion),
  • swelling,
  • rapid weight gain,
  • severe headache,
  • blurred vision,
  • knocking in the neck or ears,
  • loss of appetite,
  • stomach pain (upper right side),
  • flu-like symptoms,
  • itching,
  • dark urine and
  • yellowing of the skin or eyes (jaundice)

Rare side effects of labetalol include:

  • none

This is not a complete list of side effects and other serious side effects or health problems may result from the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You can report side effects or health concerns to the FDA at 1-800-FDA-1088.

What are the dosages of labetalol?

Adult and pediatric dosage

Injection solution

  • 5 mg/ml

tablet

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  • 100mg
  • 200mg
  • 300mg

Hypertension

Adult

  • 100 mg orally every 12 hours initially; increase by 100 mg every 12 hours every 2-3 days
  • Usual dose range: 200-400 mg orally every 12 hours; no more than 2400 mg / day.

Hypertension emergency

Can Tylenol be taken with Cephalexin?

Adult

  • 20 mg IV over 2 minutes initially, then 40-80 mg IV every 10 minutes; the total dose should not exceed 300 mg
  • Alternative: 1-2 mg/min by continuous intravenous infusion; a total dose of 300 mg has been used

Pediatric

  • 0. 4-1 mg/kg/hour by continuous intravenous infusion; not more than 3 mg/kg/h

Dosage considerations – should be given as follows:

  • See “Dosages”.

What other drugs interact with labetalol?

If your doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any potential drug interactions and can monitor them. Do not start, stop, or change the dosage of any medicine without talking to your doctor, health care provider, or pharmacist.

  • Labetalol has serious interactions with the following drugs:
    • iobenguane I 123
  • Labetalol has serious interactions with at least 19 other drugs.
  • Labetalol interacts moderately with at least 168 other drugs.
  • Labetalol has minor interactions with at least 32 other drugs.

This information does not contain all possible interactions or side effects. Visit the RxList Drug Interaction Checker to learn about any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all products you use. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Consult with your physician or healthcare professional for further medical advice, or if you have health questions, concerns.

What are the warnings and precautions for labetalol?

Contraindications

woke up with swollen tongue

  • Hypersensitivity
  • Asthma or obstructive airway disease, severe bradycardia, 2º/3º heart block (without pacemaker), cardiogenic shock, bronchial asthma, uncompensated heart failure, hypersensitivity, sinus bradycardia, sick sinus syndrome without permanent pacemaker; conditions associated with prolonged and severe hypotension.

Consequences of drug abuse

  • Nobody

Short-term effects

  • See “What side effects are associated with the use of labetalol?”

Long-term effects

  • See “What side effects are associated with the use of labetalol?”

Cautions

  • Use with caution in anesthesia or surgery (myocardial depression), bronchospastic disease (not recommended), cerebrovascular insufficiency, diabetes diabetes hyperthyroidism or thyrotoxicosis, liver failure, renal failure, peripheral vascular disease, compromised left biliary subsidiary function, advanced age, heart failure, pheochromocytoma
  • Increased risk of stroke after surgery
  • Serious liver injury reported with use; with long-term use monitor liver function tests
  • Sudden cessation may exacerbate angina pectoris and lead to myocardial infarction
  • Use with caution in patients taking calcium channel blockers, cardiac glycosides or inhalational anesthetics
  • Intraoperative flexible iris syndrome observed during cataract surgery in some patients treated with alpha1 blockers (labetalol is both an alpha and a beta blocker)
  • Hypotension with or without syncope may occur; monitor
  • Consider pre-existing conditions such as sinus syndrome disease before initiating therapy
  • Use caution in patients with severe anaphylaxis to allergens; patients taking beta-blockers may become more sensitive to repeated tests; treatment with epinephrine in patients taking beta-blockers may be ineffective or cause unwanted effects
  • Use with caution in patients with myasthenia gravis, psoriasis, or mental illness (may cause or exacerbate CNS depression)

Pregnancy and lactation

  • Use with caution if benefits outweigh risks.