What is an HbA1c test. How does it measure blood sugar levels. Why is it important for diabetes management. When should you get an HbA1c test. How to interpret HbA1c results. What factors can affect HbA1c levels. How does HbA1c relate to daily blood sugar monitoring.

The Fundamentals of HbA1c Blood Testing

The Hemoglobin A1C (HbA1c) test is a crucial diagnostic tool in the realm of diabetes management. This simple blood test provides valuable insights into a person’s average blood sugar levels over the past three months, offering a comprehensive view of long-term glucose control.

How does the HbA1c test work? When glucose enters the bloodstream, it attaches to hemoglobin, a protein found in red blood cells. The HbA1c test measures the percentage of red blood cells that have sugar-coated hemoglobin. This percentage directly correlates with average blood sugar levels, making it an effective indicator of diabetes risk and management efficacy.

Key Benefits of HbA1c Testing

• Provides a 3-month average of blood sugar levels
• Helps diagnose prediabetes and diabetes
• Assists in monitoring diabetes management
• Indicates the risk of diabetes-related complications

Is the HbA1c test better than daily blood sugar monitoring? While HbA1c testing offers a long-term perspective, it doesn’t replace regular blood sugar testing. Daily monitoring captures the fluctuations in glucose levels throughout the day, which the HbA1c test cannot reveal. Both methods are complementary and essential for comprehensive diabetes management.

Who Should Get an HbA1c Test and When?

HbA1c testing is recommended for various groups of people, depending on their age, risk factors, and existing health conditions. Understanding when to get tested is crucial for early detection and effective management of diabetes.

Testing Guidelines for Different Groups

1. Adults over 45: Baseline test recommended
2. Adults under 45 with risk factors: Test if overweight and have additional risk factors
3. Individuals with prediabetes: Test every 1-2 years
4. People with diabetes: Test at least twice a year

How often should you get an HbA1c test if you have diabetes? For most people with diabetes, testing at least twice a year is recommended. However, if your medication changes or you have other health conditions, your doctor may advise more frequent testing. It’s essential to discuss the appropriate testing frequency with your healthcare provider.

Interpreting HbA1c Results: What Do the Numbers Mean?

Understanding your HbA1c results is crucial for assessing your risk of diabetes or evaluating your diabetes management. The test results are typically expressed as a percentage, representing the amount of glycated hemoglobin in your blood.

HbA1c Levels and Their Interpretations

• Below 5.7%: Normal
• 5.7% to 6.4%: Prediabetes
• 6.5% or above: Diabetes

What does an HbA1c level of 6% mean? An HbA1c level of 6% falls within the prediabetes range. This indicates that your average blood sugar levels over the past three months have been higher than normal, but not high enough to be diagnosed as diabetes. It’s a warning sign that you’re at increased risk of developing type 2 diabetes and should take steps to improve your health.

For those managing diabetes, HbA1c results can also be reported as estimated average glucose (eAG). This measurement translates the HbA1c percentage into the same unit (mg/dL) used in daily blood sugar monitoring, providing a more familiar reference point for patients.

Factors Influencing HbA1c Results: Beyond Blood Sugar

While HbA1c is generally a reliable indicator of average blood sugar levels, several factors can affect the accuracy of the results. It’s important to be aware of these potential influences to ensure proper interpretation of your test results.

Common Factors Affecting HbA1c Accuracy

• Kidney failure or liver disease
• Severe anemia
• Certain hemoglobin variants
• Specific medications (e.g., opioids, some HIV medications)
• Recent blood loss or transfusions
• Pregnancy

Can anemia affect HbA1c results? Yes, severe anemia can impact HbA1c test results. Anemia affects the lifespan of red blood cells, which in turn can lead to falsely low HbA1c readings. This is why it’s crucial to inform your healthcare provider about any existing health conditions or medications that might influence your test results.

Setting and Achieving HbA1c Goals in Diabetes Management

For individuals with diabetes, establishing and working towards an HbA1c goal is a fundamental aspect of disease management. While the general target for most people with diabetes is 7% or less, it’s important to recognize that HbA1c goals should be personalized based on individual circumstances.

Factors Influencing HbA1c Goals

• Age
• Duration of diabetes
• Presence of other medical conditions
• Risk of hypoglycemia
• Individual lifestyle and preferences

Why might younger people with diabetes have lower HbA1c goals? Younger individuals typically have more years living with diabetes ahead of them. Setting lower HbA1c goals for this group aims to reduce the long-term risk of diabetes-related complications. However, it’s crucial to balance this with the risk of hypoglycemia and maintain a realistic, achievable target.

Achieving your HbA1c goal often requires a multifaceted approach, including medication management, dietary changes, regular exercise, and consistent blood sugar monitoring. Working closely with your healthcare team to develop and adjust your diabetes management plan is key to reaching and maintaining your target HbA1c level.

The Role of HbA1c in Prediabetes Management

Prediabetes, characterized by HbA1c levels between 5.7% and 6.4%, serves as a critical warning sign for potential type 2 diabetes development. Recognizing and addressing prediabetes can significantly reduce the risk of progressing to full-blown diabetes.

Strategies for Managing Prediabetes

1. Regular physical activity
2. Healthy diet rich in whole foods
3. Weight management
4. Stress reduction
5. Regular HbA1c monitoring

How effective are lifestyle changes in preventing diabetes progression? Research has shown that lifestyle modifications can be highly effective in preventing or delaying the onset of type 2 diabetes in people with prediabetes. The Diabetes Prevention Program, a large clinical study, found that participants who made intensive lifestyle changes reduced their risk of developing diabetes by 58% compared to those who didn’t make changes.

For individuals diagnosed with prediabetes, regular HbA1c testing becomes crucial. Your healthcare provider may recommend testing every 1 to 2 years to monitor your progress and adjust interventions as needed. This ongoing surveillance allows for timely adjustments to your prevention strategy, potentially averting the development of type 2 diabetes.

HbA1c Testing: Preparation and Procedure

One of the advantages of the HbA1c test is its simplicity and the minimal preparation required. Unlike some other medical tests, the HbA1c test doesn’t typically require fasting or any special dietary restrictions beforehand.

Steps in HbA1c Testing

1. Blood sample collection (finger stick or arm vein)
2. Laboratory analysis
3. Result interpretation by healthcare provider
4. Discussion of results and implications

Does the HbA1c test require fasting? No, the HbA1c test does not require fasting. This is because the test measures average blood sugar levels over the past three months, rather than providing a snapshot of your current blood sugar level. This makes the HbA1c test more convenient for many patients compared to tests that require fasting.

While specific preparation isn’t necessary for the HbA1c test itself, it’s important to inform your healthcare provider about any medications you’re taking, recent illnesses, or other factors that might influence your results. Additionally, if other tests are scheduled alongside your HbA1c test, you may need to follow preparation instructions for those tests.

Integrating HbA1c Results with Daily Blood Sugar Monitoring

While the HbA1c test provides valuable insights into long-term blood sugar control, it’s most effective when used in conjunction with daily blood sugar monitoring. Understanding how these two methods of glucose assessment complement each other is crucial for comprehensive diabetes management.

Benefits of Combining HbA1c and Daily Monitoring

• Comprehensive view of glucose control
• Identification of daily blood sugar patterns
• Better informed treatment decisions
• Enhanced ability to prevent complications

Why is daily blood sugar monitoring important even with regular HbA1c tests? Daily blood sugar monitoring captures the day-to-day and hour-to-hour fluctuations in your glucose levels. This information is crucial for making immediate adjustments to diet, exercise, or medication. HbA1c, on the other hand, provides a long-term average but doesn’t show these short-term variations.

For example, two individuals might have the same HbA1c level, but their daily blood sugar patterns could be vastly different. One person might have relatively stable glucose levels throughout the day, while another experiences significant highs and lows. These patterns, which are only visible through regular self-monitoring, can significantly impact treatment decisions and quality of life.

Integrating HbA1c results with daily monitoring data allows for a more nuanced and personalized approach to diabetes management. It enables healthcare providers to fine-tune treatment plans, addressing both long-term control and day-to-day glucose management. This comprehensive approach is key to reducing the risk of diabetes-related complications and improving overall health outcomes.

Advanced Applications of HbA1c Testing in Research and Clinical Practice

Beyond its role in diagnosing and monitoring diabetes, HbA1c testing has found applications in various areas of medical research and clinical practice. These advanced uses of HbA1c are contributing to our understanding of diabetes and its relationship to other health conditions.

Emerging Applications of HbA1c Testing

• Cardiovascular risk assessment
• Prediction of diabetes-related complications
• Evaluation of new diabetes treatments
• Population-level diabetes surveillance

How is HbA1c being used in cardiovascular risk assessment? Recent research has shown that elevated HbA1c levels, even in the prediabetic range, are associated with an increased risk of cardiovascular disease. As a result, some clinicians are incorporating HbA1c levels into cardiovascular risk calculations, alongside traditional factors like blood pressure and cholesterol levels.

In the realm of research, HbA1c testing plays a crucial role in evaluating the efficacy of new diabetes treatments. Clinical trials often use changes in HbA1c levels as a primary outcome measure to assess the effectiveness of medications, lifestyle interventions, or other therapeutic approaches.

Additionally, population-level HbA1c data is being used for public health surveillance and policy planning. By tracking average HbA1c levels across different demographic groups, health authorities can identify trends in diabetes prevalence and control, informing targeted interventions and resource allocation.

As our understanding of the relationship between glycemic control and various health outcomes continues to evolve, it’s likely that the applications of HbA1c testing will expand further. This underscores the importance of ongoing research and the potential for HbA1c to contribute to advancements in personalized medicine and public health strategies.

The Future of HbA1c Testing: Innovations and Challenges

As medical technology continues to advance, the landscape of HbA1c testing is evolving. New innovations promise to enhance the accuracy, accessibility, and utility of HbA1c measurements, while also presenting new challenges for healthcare providers and patients to navigate.

Emerging Trends in HbA1c Testing

• Point-of-care HbA1c testing
• Continuous glucose monitoring integration
• Artificial intelligence-assisted interpretation
• Personalized HbA1c targets based on genetic factors

What are the benefits of point-of-care HbA1c testing? Point-of-care HbA1c testing allows for rapid results during a patient visit, enabling immediate treatment decisions and reducing the need for follow-up appointments. This can improve patient convenience and potentially enhance adherence to diabetes management plans.

The integration of HbA1c data with continuous glucose monitoring (CGM) systems is another promising development. By combining long-term HbA1c trends with detailed, real-time glucose data from CGM devices, healthcare providers can gain a more comprehensive understanding of a patient’s glucose control and tailor interventions more precisely.

Artificial intelligence and machine learning algorithms are being developed to assist in the interpretation of HbA1c results in conjunction with other health data. These tools have the potential to identify subtle patterns and risk factors that might not be apparent through traditional analysis, potentially leading to more personalized and effective diabetes management strategies.

However, these advancements also bring challenges. Ensuring the accuracy and standardization of new testing methods, managing and interpreting large volumes of data, and addressing potential disparities in access to advanced technologies are all important considerations as HbA1c testing continues to evolve.

As we look to the future, it’s clear that HbA1c testing will remain a cornerstone of diabetes care while also expanding its role in broader health assessment and personalized medicine. Staying informed about these developments will be crucial for both healthcare providers and patients in optimizing diabetes management and overall health outcomes.

All About Your A1C

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What has your blood sugar been up to lately? Get an A1C test to find out your average levels—important to know if you’re at risk for prediabetes or type 2 diabetes, or if you’re managing diabetes.

The A1C test—also known as the hemoglobin A1C or HbA1c test—is a simple blood test that measures your average blood sugar levels over the past 3 months. It’s one of the commonly used tests to diagnose prediabetes and diabetes, and is also the main test to help you and your health care team manage your diabetes. Higher A1C levels are linked to diabetes complications, so reaching and maintaining your individual A1C goal is really important if you have diabetes.

What Does the A1C Test Measure?

When sugar enters your bloodstream, it attaches to hemoglobin, a protein in your red blood cells. Everybody has some sugar attached to their hemoglobin, but people with higher blood sugar levels have more. The A1C test measures the percentage of your red blood cells that have sugar-coated hemoglobin.

Who Should Get an A1C Test, and When?

Testing for diabetes or prediabetes:
Get a baseline A1C test if you’re an adult over age 45—or if you’re under 45, are overweight, and have one or more risk factors for prediabetes or type 2 diabetes:

• If your result is normal but you’re over 45, have risk factors, or have ever had gestational diabetes, repeat the A1C test every 3 years.
• If your result shows you have prediabetes, talk to your doctor about taking steps now to improve your health and lower your risk for type 2 diabetes. Repeat the A1C test as often as your doctor recommends, usually every 1 to 2 years.
• If you don’t have symptoms but your result shows you have prediabetes or diabetes, get a second test on a different day to confirm the result.
• If your test shows you have diabetes, ask your doctor to refer you to diabetes self-management education and support services so you can have the best start in managing your diabetes.

Managing diabetes:
If you have diabetes, get an A1C test at least twice a year, more often if your medicine changes or if you have other health conditions. Talk to your doctor about how often is right for you.

How to Prepare for Your A1C Test

The test is done in a doctor’s office or a lab using a sample of blood from a finger stick or from your arm. You don’t need to do anything special to prepare for your A1C test. However, ask your doctor if other tests will be done at the same time and if you need to prepare for them.

Your A1C Result

Diagnosing Prediabetes or Diabetes

A normal A1C level is below 5.7%, a level of 5. 7% to 6.4% indicates prediabetes, and a level of 6.5% or more indicates diabetes. Within the 5.7% to 6.4% prediabetes range, the higher your A1C, the greater your risk is for developing type 2 diabetes.

Managing Diabetes
Your A1C result can also be reported as estimated average glucose (eAG), the same numbers (mg/dL) you’re used to seeing on your blood sugar meter:

What Can Affect Your A1C Result?

Get your A1C tested in addition to—not instead of—regular blood sugar self-testing if you have diabetes.

Several factors can falsely increase or decrease your A1C result, including:

• Kidney failure, liver disease, or severe anemia.
• A less common type of hemoglobin that people of African, Mediterranean, or Southeast Asian descent and people with certain blood disorders (such as sickle cell anemia or thalassemia) may have.
• Certain medicines, including opioids and some HIV medications.
• Blood loss or blood transfusions.
• Early or late pregnancy.

Let your doctor know if any of these factors apply to you, and ask if you need additional tests to find out.

Your A1C Goal

The goal for most people with diabetes is 7% or less. However, your personal goal will depend on many things such as your age and any other medical conditions. Work with your doctor to set your own individual A1C goal.

Younger people have more years with diabetes ahead, so their goal may be lower to reduce the risk of complications, unless they often have hypoglycemia (low blood sugar, or a “low”). People who are older, have severe lows, or have other serious health problems may have a higher goal.

A1C: Just Part of the Toolkit

A1C is an important tool for managing diabetes, but it doesn’t replace regular blood sugar testing at home. Blood sugar goes up and down throughout the day and night, which isn’t captured by your A1C. Two people can have the same A1C, one with steady blood sugar levels and the other with high and low swings.

If you’re reaching your A1C goal but having symptoms of highs or lows, check your blood sugar more often and at different times of day. Keep track and share the results with your doctor so you can make changes to your treatment plan if needed.

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What is HbA1c? | Blood Test | Target Levels

HbA1c is your average blood glucose (sugar) levels for the last two to three months.

If you have diabetes, an ideal HbA1c level is 48mmol/mol (6.5%) or below.

If you’re at risk of developing type 2 diabetes, your target HbA1c level should be below 42mmol/mol (6%).

On this page we’ll go through what HbA1c means, and why aiming for your target level is so important. We’ll also explain the HbA1c test in more detail, and show you what you can do to lower your HbA1c levels if they’re too high. Plus, you can use our HbA1c converter tool if you’re looking to find out your level in % or mmol/mol. 

What does HbA1c mean?

HbA1c is what’s known as glycated haemoglobin. This is something that’s made when the glucose (sugar) in your body sticks to your red blood cells. Your body can’t use the sugar properly, so more of it sticks to your blood cells and builds up in your blood. Red blood cells are active for around 2-3 months, which is why the reading is taken quarterly.

A high HbA1c means you have too much sugar in your blood. This means you’re more likely to develop diabetes complications, like serious problems with your eyes and feet.

Knowing your HbA1c level and what you can do to lower it will help you reduce your risk of devastating complications. This means getting your HbA1c checked regularly. It’s a vital check and part of your annual review. You’re entitled to get this test at least once a year. But if your HbA1c is high or needs a little more attention, it’ll be done every three to six months. It’s really important not to skip these tests, so if you haven’t had one in over a year contact your healthcare team.

Once you know your HbA1c level, it’s important that you understand what the results mean and how to stop them from getting too high. Even a slightly raised HbA1c level makes you more at risk of serious complications, so get all the facts here and be in the know about HbA1c.

What is a HbA1c test?

The hemoglobin A1c (HbA1c) test measures the amount of blood sugar (glucose) attached to your hemoglobin. Hemoglobin is the part of your red blood cells that carries oxygen from your lungs to the rest of your body. It is an important blood test that gives a good indication of how well your diabetes is being controlled.

You can check these average blood sugar levels yourself, but you’ll have to buy a kit, whereas your healthcare professional will do it for free. It’s different from a finger-prick test, which is a snapshot of your blood sugar levels at a particular time, on a particular day.

You find out your HbA1c level by getting a blood test by a doctor or nurse. Your healthcare team will arrange this for you, but chase it up with your GP if you haven’t had one for a few months. 

Most people will have the test every three to six months. But you may need it more often if you’re planning for a baby, your treatment has recently changed, or you’re having problems managing your blood sugar levels.

And some people will need the test less often, usually later on during pregnancy. Or need a different test altogether, like with some types of anaemia. A fructosamine test can be used instead, but it’s very rare.

An HbA1c test is also used to diagnose diabetes, and to keep an eye on your levels if you’re at risk of developing diabetes (you have prediabetes).

The test is sometimes called haemoglobin A1c or just A1c.

Your HbA1c results

You should get the results quickly. The result of the HbA1c test lets your healthcare team know if they need to change your treatment or medication to help you manage your levels better. But it also tells you a number and it’s important you understand what this means. Some people find it helps to write their results down in a diary, to keep track of them and see if they can spot any trends.

And your HbA1c can change for lots of reasons, including:

• if you’re unwell
• if you’re taking other medicines, like steroids
• changes in lifestyle
• if you’re feeling very stressed or you’re depressed.

You’ll talk to your healthcare team about a target level that you need to aim for. We know this isn’t as easy as it sounds, but it’s important you do everything you can to keep in your target range. The longer your HbA1c level is even slightly high, the more you’re at risk of developing life-threatening complications.

We have lots of information and tools to help you lower your HbA1c.

What is a normal range for an HbA1c test?

If you have diabetes, an ideal HbA1c level is 48mmol/mol (6.5%) or below.

HbA1c levels and targets

But everyone’s different. So your healthcare team may give you an individual target level that takes into account your current level and when your next test is. So you can bring it down in stages and isn’t a sudden big drop.

And we’re not saying it’s easy to get to and stay at this level. We know it’s difficult, and we’re here to give you advice and information to help.

If you’re at risk of type 2 diabetes

There are different target HbA1c levels for people at risk of developing type 2 diabetes. If you’ve been told you’re at risk, your target level should be below 42mmol/mol (6%). We have lots more information for you if you’re at risk of type 2.

Type 2 diabetes remission

Remission is when a person with type 2 diabetes has healthy blood glucose (also called sugar) levels for the long-term, without taking any diabetes medications. We’re working with international experts to agree this, but our researchers used an HbA1c level of 48mmol/mol (6.5%) or less to define remission.

Type 2 diabetes is still a serious condition. It can be lifelong and get worse over time for many, but it doesn’t have to be like this for everyone. This can be life-changing. Find out more about type 2 diabetes remission.

HbA1c converter

If you’re wondering how to convert HbA1c mmol/mol to %, or vice versa, our tool can help you. 

Mmol/mol stands for millimoles per mole. A mole is a scientific unit often used to measure chemicals, and it has been the standard measurement for glucose levels since 2009. Before that, a percentage was used. That’s why measurements often have a percentage as well.

If you’re more used to the percentage system, use our converter tool below to find out your level in millimoles.

How to lower your HbA1c levels

If your levels have gone above your target since your last check, it’s understandable to be worried. Even a slightly high HbA1c level puts you more at risk of developing serious complications in your body. But knowing your numbers and what that means is an important and good first step – now you need to know how to lower them.

Lots of things can cause your HbA1c levels to change and there’s action you and your healthcare team can take to bring them down to your target level:

• Your diabetes team may need to review your medication and increase the dose or try a new one.
• Ask them about local diabetes education courses – there’s always more to learn with diabetes and a course will help you take practical steps to lower your HbA1c.
• Get more active – moving more is good for everyone, but it can specifically help to bring down your HbA1c levels.
• Get advice on balanced, healthy eating.
• Stop smoking – smoking makes it harder for blood to flow around your body. 

And if you want to hear from others who are experiencing this too, think about joining our online forum. It’s a place where you can chat to others or just read other people’s stories.

And don’t forget, get advice from your healthcare team. They’re here to help.

HbA1c test and finger-prick test – what’s the difference?

Get more information on checking your own blood sugars using a finger-prick test.

HbA1c test	Finger-prick test
Measures your average blood sugar levels over last 2 to 3 months	Snapshot of blood sugar levels at the time
Everyone with diabetes should have this test	Only people taking certain medicines need to do this test, like insulin and sulphonylureas
Usually done every 3 to 6 months	Done a number of times a day, usually ranging from twice to 10 times
Blood is taken from arm or finger	Tiny drop of blood taken from the finger
A healthcare professional should do this for you, though you can pay for a kit and do it yourself. These aren’t available on prescription.	You can do this yourself, using a testing kit
Doctors can use this test to find out how someone is managing their diabetes, to diagnose diabetes and find out if someone is at risk of type 2 diabetes	This test is mainly used for people living with diabetes

Glycated hemoglobin (HbA1c)

Glycated hemoglobin (A1c) is a specific compound of erythrocyte hemoglobin with glucose, the concentration of which reflects the average blood glucose over a period of about three months.

Synonyms Russian

Glycohemoglobin, hemoglobin A1c, Hb _A1c , glycosylated hemoglobin.

English synonyms

Glycated hemoglobin, hemoglobin A1c, HbA1c, glycohemoglobin, glycosylated hemoglobin.

Test method *

Ion exchange high performance liquid chromatography (HPLC).

* Method may vary in some regions.

Units

% (percentage).

What biomaterial can be used for research?

Venous blood.

How to properly prepare for an examination?

• Do not eat for 2-3 hours before the examination, you can drink pure non-carbonated water.
• Exclude physical and emotional overexertion within 30 minutes prior to the study.
• Do not smoke for 30 minutes before the test.

Overview of the study

The glycated hemoglobin (A1c) test helps to assess the average blood glucose level over the past 2-3 months.

Hemoglobin is an oxygen-carrying protein found inside red blood cells (erythrocytes). There are several types of normal hemoglobin, and many abnormal varieties have been identified, although the predominant form is hemoglobin A, which is 95-98% of total hemoglobin. Hemoglobin A is divided into several components, one of which is A1c. Part of the glucose circulating in the blood spontaneously binds to hemoglobin, forming the so-called glycated hemoglobin. The higher the concentration of glucose in the blood, the more glycated hemoglobin is formed. Having combined with hemoglobin, glucose remains “in conjunction” with it until the very end of the life of the erythrocyte, that is, 120 days. The combination of glucose with hemoglobin A is called HbA1c or A1c. Glycated hemoglobin is formed in the blood and disappears from it every day, as old red blood cells die, and young (not yet glycated) take their place.

The hemoglobin A1c test is used to monitor the condition of patients diagnosed with diabetes mellitus. It helps to assess how effectively the regulation of glucose levels during treatment is going on.

For some patients, a hemoglobin A1c test is prescribed to diagnose diabetes and pre-diabetes in addition to a fasting plasma glucose test and a glucose tolerance test.

The resulting value is measured as a percentage. Patients with diabetes should strive to keep their glycated hemoglobin levels below 7%.

A1c should be reported in one of three ways:

• as a percentage of total hemoglobin,
• in mmol/mol, according to the International Federation of Clinical Chemistry and Laboratory Medicine,
• as mean glucose mg/dl or mmol/l.

What is research used for?

• For the control of glucose in patients with diabetes mellitus – for them to maintain its level in the blood as close to normal as possible is very important. This helps to minimize complications to the kidneys, eyes, cardiovascular and nervous systems.
• To determine the patient’s average blood glucose over the past few months.
• To validate the correctness of the measures taken for the treatment of diabetes and to find out if they need to be adjusted.
• To detect uncontrolled rises in blood glucose in patients with newly diagnosed diabetes mellitus. Moreover, the test may be prescribed several times until the desired glucose level is detected, then it needs to be repeated several times a year to make sure that the normal level is maintained.
• For preventive purposes, to diagnose diabetes at an early stage.

When is the test ordered?

Depending on the type of diabetes and how well the disease is treated, A1c is tested 2 to 4 times a year. On average, patients with diabetes are recommended to be tested for A1c twice a year. If the patient is diagnosed with diabetes for the first time or the control measurement fails, the analysis is re-assigned.

In addition, this test is ordered if the patient is suspected of having diabetes because there are symptoms of high blood glucose:

• extreme thirst,
• frequent copious urination,
• fatigue,
• blurred vision,
• increased susceptibility to infections.

What do the results mean?

Reference values: * 4. 27 – 6.07%.

*Reference values ​​vary for some regions due to the use of different test systems for the study.

The closer the A1c level is to 7% in a diabetic patient, the easier it is to control the disease. Accordingly, with an increase in the level of glycated hemoglobin, the risk of complications also increases.

The results of the analysis for A1c are interpreted as follows.

According to the clinical guidelines of the Ministry of Health of the Russian Federation of the Russian Association of Endocrinologists “Algorithms for specialized medical care for patients with diabetes mellitus” (2019), an additional diagnostic indicator is the average daily plasma glucose level (AGG) for the last three months and its correlation with the level of HbA1c.

What can influence the result?

Patients with abnormal hemoglobin, such as those with sickle cells, will have low glycated hemoglobin. In addition, if a person suffers from anemia, severe bleeding, his test results may also be underestimated. On the contrary, A1c values ​​are overestimated with iron deficiency and with a recent blood transfusion (since liquid blood preservatives contain a high concentration of glucose).

Important Notes

The A1c test does not reflect sudden changes in blood glucose. Glucose fluctuations in patients with labile diabetes will also not be detected by this test.

Also recommended

• Plasma glucose
• Glucose tolerance test
• Fructosamine

Who orders the examination?

Therapist, endocrinologist.

Test for glycated hemoglobin

Method of determination
Colorimetric.

Test material
Whole blood (with EDTA)

Home visit available

Online check-in

Synonyms: Blood test for glycated hemoglobin. Glycohemoglobin; HbA1c; Hemoglobin A1c; A1c; HgbA1c; Hb1c.

Brief characteristics of the analyte Glycated hemoglobin

It is formed as a result of the slow non-enzymatic addition of glucose to hemoglobin A contained in erythrocytes. Glycated (the term “glycosylated” is also used) hemoglobin is present in the blood in healthy people. The rate of this non-enzymatic addition of glucose and the amount of glycated hemoglobin formed depend on the average blood glucose level over the lifetime of red blood cells. As a result of the reaction, several forms of glycated hemoglobins are formed: HbA1a, HbA1b, HbA1c. The latter form quantitatively predominates and more closely correlates with the severity of diabetes mellitus. Glycated hemoglobin reflects hyperglycemia that has occurred throughout the life of erythrocytes (up to 120 days). Erythrocytes circulating in the blood have different ages. Usually they are guided by an average period of 60 days. The level of glycated hemoglobin is an indicator of the compensation of carbohydrate metabolism during this period of time, and is used to evaluate the effectiveness of diet and treatment. Normalization of the level of glycated hemoglobin in the blood occurs 4-6 weeks after reaching a normal glucose level.

In patients with diabetes, the level of HbA1c may be increased by 2-3 times. In accordance with the recommendations of the World Health Organization (WHO), this test is recognized as optimal and necessary for the control of diabetes.

What determines the result of the test for Glycated hemoglobin

Glycated hemoglobin is used as an indicator of the risk of developing complications of diabetes. Clinical studies show that a 1% increase in the proportion of glycated hemoglobin (measured by certified methods) is associated with an increase in plasma glucose levels of approximately 2 mmol/l. Normalization of the level of glycated hemoglobin in the blood occurs 4-6 weeks after reaching a normal glucose level. Patients with diabetes are recommended to study the level of glycated hemoglobin twice a year if therapy is stable and target values ​​​​are achieved, but at least once a quarter if therapy is changed or target values ​​\u200b\u200bof HbA1c are not achieved. The usual HbA1c targets for adults in diabetes therapy are below or near 7.0%. The physician’s choice of individual HbA1c targets may depend on the patient’s age, comorbidities, presence of complications, risk of severe hypoglycemia, and life expectancy.

In 2011, WHO approved the use of HbA1c to diagnose diabetes. The test must be performed using an HbA1c test certified by the National Glycohemoglobin Standardization Program (NGSP) or International Federation of Clinical Chemists (IFCC) and standardized by the Diabetes Control and Complications Trial (DCCT). The level of HbA1c ≥ 6.5% (48 mmol/mol) was chosen as a diagnostic criterion for diabetes mellitus.