What are DIUREX Max Water Caplets used for. How do they work to relieve water retention. What is the active ingredient in DIUREX Max Water Caplets. Are there any side effects or precautions to be aware of.

Understanding DIUREX Max Water Caplets: Purpose and Function

DIUREX Max Water Caplets are a popular over-the-counter medication designed to address specific female health concerns. These caplets primarily target temporary water weight gain, bloating, and other discomforts commonly associated with premenstrual and menstrual periods. By focusing on these symptoms, DIUREX Max aims to provide relief and comfort during challenging times of the month.

Is there a specific mechanism by which DIUREX Max works? The caplets function as a mild diuretic, promoting the body’s natural ability to expel excess water. This action can help reduce bloating and alleviate the sensation of fullness that many women experience during their menstrual cycle.

The Active Ingredient: Pamabrom Explained

At the heart of DIUREX Max Water Caplets lies a single active ingredient: Pamabrom. Each caplet contains 50 mg of this compound, which plays a crucial role in the product’s effectiveness. But what exactly is Pamabrom?

Pamabrom is a mild diuretic that shares similarities with caffeine in its molecular structure. However, it offers a unique benefit: it provides the water-relieving properties of caffeine without the stimulatory effects. This means users can experience the desired reduction in water retention without feeling jittery or overstimulated.

How Does Pamabrom Compare to Other Diuretics?

• Milder action compared to prescription diuretics
• Fewer side effects than stronger alternatives
• Specifically formulated for menstrual-related water retention
• Over-the-counter availability for convenience

Proper Usage and Dosage Guidelines

To maximize the benefits of DIUREX Max Water Caplets while minimizing potential risks, it’s essential to follow the recommended dosage instructions carefully. The standard dosage is one caplet taken after breakfast with a full glass of water. If needed, this dose may be repeated after 6 hours, but users should never exceed 4 caplets within a 24-hour period.

Why is proper hydration important when taking DIUREX Max? Drinking a full glass of water with each dose helps support the diuretic action of the medication while preventing dehydration. This ensures that the body can effectively eliminate excess water without compromising overall hydration levels.

Safety Considerations and Potential Interactions

While DIUREX Max Water Caplets are generally considered safe for most users, there are some important safety considerations to keep in mind. First and foremost, these caplets do not contain sulfa drugs, which is beneficial for individuals with sulfa allergies.

Can DIUREX Max be used continuously? The product packaging advises against using the caplets for more than 10 consecutive days without consulting a healthcare professional. This precaution helps prevent potential overuse and allows for proper medical oversight if extended use is necessary.

Interactions with Other Medications

For individuals taking prescription medications, it’s crucial to consult with a doctor or pharmacist before incorporating DIUREX Max into their regimen. Potential interactions may occur, and a healthcare professional can provide personalized advice based on an individual’s specific medical history and current medications.

Beyond Menstrual Relief: Other Potential Uses

While DIUREX Max Water Caplets are primarily marketed for menstrual-related water retention, some individuals may wonder about their effectiveness for other conditions. Can DIUREX Max be used to address swelling in the feet and ankles? Is it suitable for individuals who no longer have menstrual periods?

In these cases, it’s important to note that the product is specifically designed and approved for menstrual-related symptoms. For any off-label use, consulting with a healthcare professional is strongly recommended. They can provide guidance on whether DIUREX Max is appropriate for other conditions and suggest alternative treatments if necessary.

Gender Considerations: Can Men Use DIUREX Max?

Given that DIUREX Max is marketed primarily towards women, a common question arises: can men use this product? The answer isn’t straightforward. While the active ingredient, Pamabrom, doesn’t have gender-specific effects, the product is formulated and dosed for menstrual-related water retention.

For men considering DIUREX Max, what should they keep in mind? It’s crucial to consult with a healthcare provider before use. A doctor can assess whether the product is appropriate for a man’s specific needs or if alternative treatments would be more suitable.

DIUREX Water Pills + Pain Relief: A Comprehensive Solution

In addition to DIUREX Max Water Caplets, the DIUREX product line includes DIUREX Water Pills + Pain Relief. This variant offers a unique combination of ingredients to address both water retention and associated discomfort.

Active Ingredients and Their Functions

• Magnesium Salicylate (162.5 mg per pill): Provides pain relief
• Caffeine (50 mg per pill): Acts as a diuretic and mild stimulant

How do these ingredients work together? The magnesium salicylate helps alleviate pain and discomfort often associated with menstrual symptoms, while the caffeine promotes water elimination and potentially provides a mild energy boost.

Comparing DIUREX Products: Which One Is Right for You?

With multiple DIUREX products available, choosing the right one can be challenging. Here’s a quick comparison to help guide your decision:

When choosing between DIUREX products, consider your specific symptoms and sensitivities. If you’re prone to caffeine jitters, DIUREX Max might be the better choice. For those dealing with both water retention and menstrual cramps, the DIUREX Water Pills + Pain Relief could offer more comprehensive relief.

Understanding the Limitations: What DIUREX Products Can’t Do

While DIUREX products are effective for their intended use, it’s important to understand their limitations. These medications are not designed for long-term weight loss or as a “system cleanse.” Their primary function is to provide temporary relief from water retention and associated discomforts.

Can DIUREX products be used for purposes other than menstrual-related symptoms? While some may consider using these products for other types of edema or bloating, it’s crucial to consult with a healthcare professional before doing so. Off-label use may not be safe or effective, and there might be more appropriate treatments available for specific conditions.

Common Misconceptions About Diuretics

• They are not effective for long-term weight loss
• They do not “detoxify” the body
• They are not a substitute for proper hydration and nutrition
• Overuse can lead to electrolyte imbalances and dehydration

Potential Side Effects and Precautions

As with any medication, DIUREX products may cause side effects in some individuals. While the product packaging provides comprehensive information, it’s worth highlighting some key points:

Possible Side Effects

• Increased urination frequency
• Mild dehydration if not properly hydrated
• Electrolyte imbalances with prolonged use
• Stomach upset (more common with DIUREX Water Pills + Pain Relief)

To minimize the risk of side effects, always follow the recommended dosage and duration of use. If you experience any unusual symptoms or discomfort, discontinue use and consult with a healthcare professional.

The Importance of Holistic Menstrual Health Management

While DIUREX products can be effective for managing water retention and associated discomforts, they should be part of a broader approach to menstrual health. Combining medication with lifestyle changes can often yield the best results.

Complementary Strategies for Menstrual Comfort

1. Maintain a balanced diet low in sodium to reduce water retention
2. Stay hydrated to support natural fluid balance
3. Engage in regular exercise to improve circulation and reduce bloating
4. Practice stress-reduction techniques like meditation or yoga
5. Use heat therapy (e.g., heating pads) for cramp relief
6. Consider dietary supplements like magnesium or vitamin B6, under medical guidance

By incorporating these strategies alongside DIUREX products, many women find they can achieve more comprehensive relief from menstrual symptoms. Remember, everyone’s body is different, so it may take some experimentation to find the perfect combination of treatments that works for you.

When to Seek Medical Advice

While DIUREX products are available over-the-counter and generally safe for most users, there are situations where professional medical advice is necessary. When should you consult a healthcare provider regarding water retention and menstrual discomfort?

• If symptoms persist or worsen despite using DIUREX as directed
• If you experience severe bloating or sudden weight gain
• If you have underlying health conditions like heart or kidney disease
• If you’re considering using DIUREX for non-menstrual related issues
• If you’re taking other medications and are concerned about interactions

A healthcare professional can provide personalized advice, rule out any underlying conditions, and ensure that your symptom management approach is safe and effective for your individual needs.

The Future of Menstrual Symptom Management

As research in women’s health continues to advance, new treatments and approaches for managing menstrual symptoms are emerging. While products like DIUREX have been staples for many years, ongoing studies are exploring alternative methods for addressing water retention and associated discomforts.

Emerging Trends in Menstrual Health

• Personalized medicine approaches based on hormonal profiles
• Natural and herbal remedies with scientific backing
• Wearable devices for tracking and predicting menstrual symptoms
• Nutritional interventions tailored to different phases of the menstrual cycle
• Mind-body techniques for holistic symptom management

As these new approaches develop, they may complement or even replace traditional over-the-counter remedies like DIUREX for some individuals. However, the effectiveness and safety of these emerging treatments will need to be thoroughly evaluated through rigorous scientific studies before they can be widely recommended.

Conclusion: Making Informed Decisions About DIUREX Products

DIUREX Max Water Caplets and DIUREX Water Pills + Pain Relief offer targeted solutions for women dealing with menstrual-related water retention and discomfort. By understanding the active ingredients, proper usage, and limitations of these products, individuals can make informed decisions about incorporating them into their menstrual health management routine.

Remember, while these over-the-counter options can provide relief for many, they are not a one-size-fits-all solution. Always consider your individual health needs, consult with healthcare professionals when necessary, and explore complementary strategies for comprehensive menstrual wellness. By taking a holistic approach and staying informed about both traditional and emerging treatment options, you can work towards finding the most effective way to manage your menstrual symptoms and improve your overall quality of life.

DIUREX Max | Alva-Amco

What are DIUREX Max Water Caplets used for?

DIUREX Max Water Caplets help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods.

What are the active ingredients in DIUREX Max Water Caplets?

Each DIUREX Max Water Caplet contains 50 mg of Pamabrom.

What is pamabrom?

Pamabrom is a mild diuretic ingredient that is similar to caffeine. It has the water-relieving activity of caffeine, without the stimulation of caffeine.

What is the dosage for DIUREX Max Water Caplets?

The dosage for DIUREX Max Water Caplets is one caplet after breakfast with a full glass of water. Dose may be repeated after 6 hours, not to exceed 4 caplets in 24 hours. Be sure to read all product package label Directions, Uses and Warnings and follow them carefully.

Do DIUREX Max Water Caplets contain any sulfa drugs?

No, DIUREX Max Water Caplets do not contain sulfa drug ingredients.

Do DIUREX Max Water Caplets help you lose weight?

DIUREX Max Water Caplets help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. We recommend that you ask your doctor or pharmacist before using DIUREX for a purpose other than that indicated on the product package labeling and follow his or her advice.

Do DIUREX Max Water Caplets “clean out your system”?

DIUREX Max Water Caplets help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. We recommend that you ask your doctor or pharmacist before using DIUREX for a purpose other than that indicated on the product package labeling and follow his or her advice.

Can I use DIUREX Max Water Caplets continuously?

DIUREX Max Water Caplets help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. The product package labeling states that you should not use DIUREX for more than 10 consecutive days without consulting your doctor.

Can I use DIUREX Max Water Caplets to remove the swelling in my feet and ankles?

DIUREX Max Water Caplets help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. We recommend that you ask your doctor or pharmacist before using DIUREX for a purpose other than that indicated on or in the product package labeling and follow his or her advice.

Can I use DIUREX Max Water Caplets with my prescription medication(s)?

You should ask your doctor or pharmacist if you can take DIUREX Max Water Caplets while you are using other medications.

I don’t have a period any more. Can I still use DIUREX Max Water Caplets?

DIUREX Max Water Caplets help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. We recommend that you ask your doctor or pharmacist before using DIUREX for a purpose other than that indicated on the product package labeling and follow his or her advice.

Can a man use DIUREX Max Water Caplets?

DIUREX Max Water Caplets help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. We recommend that you ask your doctor or pharmacist before using DIUREX for a purpose other than that indicated on the product package labeling and follow his or her advice.

DIUREX Water Pills + Pain Relief

What are DIUREX WATER PILLS used for?

DIUREX WATER PILLS help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods.

What are the active ingredients in DIUREX WATER PILLS?

Each DIUREX WATER PILL contains 162.5 mg of magnesium salicylate and 50 mg of caffeine.

What is the dosage for DIUREX WATER PILLS?

The dosage for DIUREX WATER PILLS is two pills every 4 to 6 hours, not to exceed eight pills per day. Be sure to read all label Directions, Uses and Warnings and follow them carefully.

Do DIUREX WATER PILLS contain any sulfa drugs?

No, DIUREX WATER PILLS do not contain sulfa drug ingredients.

Are there any side effects associated with DIUREX WATER PILLS?

Information regarding the side effects which may be associated with DIUREX WATER PILLS may be found in the Warnings and Directions sections of Drug Facts for DIUREX WATER PILLS. Drug Facts may be found on the back panel of the DIUREX WATER PILLS package or on this website.

Do DIUREX WATER PILLS help you lose weight?

DIUREX WATER PILLS help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. We recommend that you ask your doctor or pharmacist before using DIUREX for a purpose other than that indicated on the product package labeling and follow his or her advice.

Do DIUREX WATER PILLS “clean out your system”?

DIUREX WATER PILLS help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. We recommend that you ask your doctor or pharmacist before using DIUREX for a purpose other than that indicated on the product package labeling and follow his or her advice.

Can I use DIUREX WATER PILLS continuously?

DIUREX WATER PILLS help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. The product package labeling states that you should not use DIUREX for more than 10 consecutive days without consulting your doctor.

Can I use DIUREX WATER PILLS to remove the swelling in my feet and ankles?

DIUREX WATER PILLS help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. We recommend that you ask your doctor or pharmacist before using DIUREX for a purpose other than that indicated on or in the product package labeling and follow his or her advice.

Can I use DIUREX WATER PILLS with my prescription medications(s)?

You should ask your doctor or pharmacist if you can take DIUREX WATER PILLS while you are using other medications.

I don’t have a period any more. Can I still use DIUREX WATER PILLS?

DIUREX WATER PILLS help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. We recommend that you ask your doctor or pharmacist before using DIUREX for a purpose other than that indicated on the product package labeling and follow his or her advice.

Can a man use DIUREX WATER PILLS?

DIUREX WATER PILLS help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. We recommend that you ask your doctor or pharmacist before using DIUREX for a purpose other than that indicated on the product package labeling and follow his or her advice.

Will DIUREX WATER PILLS show up on a drug test?

We have not had reports of the active ingredients in DIUREX WATER PILLS showing up on a drug test. However, as indicated in or on the product package labeling, DIUREX WATER PILLS may turn your urine blue or blue-green, which may be an issue in a urine test.

Do DIUREX WATER PILLS make your urine blue?

As stated on or in the product package labeling, blue or blue-green tinted urine when using DIUREX WATER PILLS is a normal and temporary effect.

Diurex (Xipamide) – instructions for use, dosage, composition, analogues, side effects / Pillintrip

Page reviewed by pharmacist Olga Valerievna Fedorchenko Last update 2022-04-02

Top 20 medicines with the same ingredients: d – 1 A PharmaXipamid AbZXipamid StadaXipamid-ratiopharmAquaphorNeotriXipamid AAA-Pharma

Name of the drug

Description The name of the drug Diurex (Xipamide) is an automatic translation from the original language.
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Diurex (Xipamide)

Composition

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Xipamide

Therapeutic indications

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For the treatment of hypertension, alone or as an adjunct to treatment with antihypertensive drugs.

For use as a diuretic.

Dosage and Administration

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1. Treatment of hypertension

Dosage:

Adults : 1 tablet (20 mg) per day as a single early morning dose. When using Diurex (Xipamide) in combination with other antihypertensive therapy, the same dose of 20 mg as a single early morning dose should be maintained.

Children : Dose not recommended.

Elderly : See Respect.

2. Use as a diuretic

Dosage :

Adults : At the initial stage of treatment, the usual dose is 2 tablets (40 mg) per day in a single early morning dose. Depending on the response of the patient, the dose may be reduced to 1 tablet per day when sufficient control of edema has been achieved. In resistant cases, higher doses may be used, up to 4 tablets per day (80 mg).

Children : Dose not recommended.

Elderly people : See “Respects”.

Contraindications

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Diurex (xipamide) is contraindicated in severe electrolyte deficiency, precoma associated with liver cirrhosis, severe renal failure, hypersensitivity to xipamide, untreated Addison’s disease, hypercalcemia, pre-existing hypovolemia, symptomatic hyperuricemia, pregnancy and lactation .

Special Warnings and Precautions

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In patients with liver disease, therapy with thiazide diuretics and related substances may cause hepatic encephalopathy. In this case, treatment with Diurex (Xipamide) should be stopped immediately.

Some cases of photosensitivity have been reported with the use of thiazide diuretics.

If a photosensitivity reaction occurs during treatment, xipamide should be discontinued. If re-administration of treatment cannot be avoided, the skin area exposed to sunlight or artificial UVA should be protected.

Pseudo-Bartter may occur in case of chronic abuse of diuretics.

Patients with rare hereditary fructose intolerance, glucose-galactose malabsorption, or sucrose-isomaltose intolerance should not take Diurex (Xipamide).

As with all antihypertensive agents, caution should be exercised in patients with severe coronary or cerebral arteriosclerosis.

An increased risk of urinary retention may occur in patients with prostatic hypertrophy.

Precautions for use of the drug:

Water and electrolyte balance:

Plasma sodium:

Plasma sodium should be monitored prior to initiation of therapy and at regular intervals during treatment. In principle, hyponatremia can occur with any diuretic treatment, with very serious complications. Since a decrease in plasma sodium levels may initially pass asymptomatically, regular monitoring is necessary; elderly patients and patients with cirrhosis of the liver should be carefully monitored (cf. adverse effects and overdose).

Potassium level:

As with other diuretics, hypokalemia may occur during long-term therapy with xipamide. Serum electrolytes (particularly potassium, sodium, calcium), bicarbonate, creatinine, urea, uric acid, and blood sugar should be monitored regularly. Potassium replacement may be required, especially in elderly patients with insufficient potassium intake.

Decreased potassium levels to the point of hypokalemia is the main risk of treatment with thiazide diuretics and closely related drugs. The occurrence of hypokalemia (plasma potassium level <3.4 mmol/l) should be avoided, especially in case of greater fluid loss (e.g. due to vomiting, diarrhea or intense sweating) and in risk groups, i.e. in elderly and / or malnourished patients and / or patients receiving treatment with several drugs, as well as in patients with cirrhosis of the liver and the formation of edema or ascites, moreover, in patients with coronary heart disease and patients with heart failure. In this group of patients, hypokalemia will also increase the cardiotoxicity of cardiac glycosides and the risk of cardiac dysrhythmia.

Hypovolemia or dehydration, as well as severe electrolyte or acid-base disturbances, must be corrected. This may require a temporary discontinuation of xipamide treatment.

Individuals with congenital or iatrogenic acquired long QT intervals are also at high risk. The presence of hypokalemia and bradycardia will contribute to the occurrence of severe arrhythmias, in particular the possible lethal pointe de torsade (polymorphic ventricular tachycardia).

All of the above cases require frequent monitoring of potassium levels, starting the first monitoring within the first week after starting therapy. Hypokalemia must be corrected.

Plasma calcium level:

Treatment with thiazide diuretics and related drugs may result in a decrease in urinary calcium excretion and a slight transient increase in plasma calcium levels. It is possible that the apparent hypercalcemia was due to a previous unexplored hyperparatriosis.

Xipamide therapy should be discontinued pending a possible study of parathyroid function.

Blood sugar level:

Especially in diabetic patients with concomitant hypokalemia, blood sugar levels should be carefully monitored.

Uric acid level:

Patients with hyperuricemia may have an increased tendency to acute gouty arthritis.

Renal function and diuretics:

Thiazide and related substances are only effective in normal or at least mild renal impairment (serum creatinine <25 mg/l or <220 Î1⁄4mol/l in adults ). In elderly patients, this serum creatinine value should be adjusted according to the age, weight and sex of the respective patient.

Hypovolemia caused by loss of water and sodium associated with diuretics at the beginning of therapy leads to a decrease in glomerular filtration rate. This can cause an increase in blood urea nitrogen (BUN) and serum creatinine. This temporary functional renal insufficiency remains without sequelae in healthy renal individuals, but may exacerbate pre-existing renal insufficiency.

In the event of treatment-resistant electrolyte decompensation, therapy should be discontinued.

Effects on ability to drive and use machines

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Xipamide may cause dizziness and electrolyte disturbances which may affect the patient’s concentration or alertness and may affect the patient’s ability to drive or operate machinery safely. This is especially true for initiation of treatment or dose changes. When affected, patients should not drive or operate a car.

Side effects

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The following side effects may occur when using thiazide diuretics and related drugs, including xipamide. With regard to clinical and chemical parameters, most adverse effects are dose dependent.

Rarely, anaphylactoid reactions may occur.

Latent diabetes mellitus may appear. In patients with diabetes, glucose levels may be increased.

At high doses, the risk of thrombosis and embolism is increased, especially in previous existing venous disorders.

Adverse events are listed below by system organ class and frequency. Frequencies are defined as: very common (> 1/l0), common (> 1/100 and <1/10), uncommon (> 1/1000 and <1/100), rare (> 1/10000 and <1/1000 ) and very rare (<1/1000), including available data cannot be known from.

Disorders of the blood and lymphatic system

Very rare: Thrombocytopenia, leukopenia, agranulocytosis, aplastic anemia (discontinuation of therapy)

Metabolic and nutritional disorders

Rare: Hyperlipidemia

Psychiatric disorders

General: Lethargy, restlessness, agitation

Nervous system disorders

Common: Headache, dizziness, dry mouth, fatigue, sweating

Visual disturbances

Rare: Minor visual disturbances, exacerbation of existing myopia (discontinuation of therapy)

Cardiac disorders

General: Palpitations

Vascular disorders

General: Orthostatic hypotension

Gastrointestinal disorders

Common: Upper abdominal discomfort, abdominal cramps, diarrhea, constipation

Rare: Hemorrhagic pancreatitis (discontinuation of therapy)

Hepatobiliary disorders

Rare: Acute cholecystitis in case of or pre-existing cholelithiasis (discontinuation of therapy)

Very rare: Jaundice (icterus)

Skin and subcutaneous tissue disorders

Uncommon: Photosensitive reactions

Rare: Allergic skin reactions (pruritus, erythema, urticaria) (discontinuation of therapy)

Musculoskeletal system and connective tissue

General : Muscle spasms/convulsions

Renal and urinary disorders

Very common: Hypokalemia which may become apparent with symptoms such as nausea, vomiting, ECG changes, glycoside hypersensitivity, arrhythmia or hypotension skeletal muscles.

General: Electrolyte and fluid disorders such as dehydration, hyponatremia, hypomagnesemia, hypochloremic alkalosis. Reversible increase in nitrogenous substances excreted in the urine (urea, creatinine), especially at the beginning of treatment. Elevated serum uric acid levels and triggering acute gouty arthritis in predisposed patients.

Very rare: Acute interstitial nephritis.

Therapy should be discontinued if:

– treatment-resistant electrolyte imbalance

– orthostatic regulatory disorders

– Hypersensitivity reactions

– Distinct gastrointestinal complaints

– Central nervous disorders

– Pancreatitis 9000 3

– changes in the blood (anemia, leukopenia, thrombocytopenia)

– acute cholecystitis

– occurrence of vasculitis

– exacerbation of existing myopia

Reporting suspected adverse reactions

Reporting suspected adverse reactions after drug approval is important. This allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are encouraged to report any suspected adverse reactions through the Yellow Card Scheme at:

www.mhra.gov.uk/yellowcard

Overdose

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There is no specific antidote for xipamide. Acute intoxications are manifested especially in violations of electrolytes and fluid balance (hyponatremia, hypokalemia). Clinical symptoms such as nausea, vomiting, drop in blood pressure, convulsions, dizziness, drowsiness, confusion, polyuria or oliguria and anuria (due to hypovolemia) may occur.

Emergency procedures: detoxification by administration of activated charcoal; subsequently restoration of the normal balance of water and electrolytes in a specialized center.

Gastric lavage or induced emesis may prevent further absorption. General measures should be aimed at maintaining blood pressure, restoring blood volume, and correcting electrolyte imbalances with appropriate intravenous infusion as needed.

Pharmacodynamics

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Xipamide is an antihypertensive diuretic that can be characterized pharmacologically as neither a thiazide nor a specific loop diuretic. Although structurally similar to chlorthalidone, it has a markedly different pharmacological profile, with its primary diuretic effect acting on the distal nephron.

As a diuretic, xipamide has been shown to be as effective as frachsemide in terms of daily urine output, but has a more gradual and prolonged effect.

Pharmacokinetics

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After a single oral dose of 20 mg xipamide, peak plasma concentrations of up to 3 µg/ml occur within 1 hour. Absolute bioavailability after oral administration is about 73%.

Xipamide is closely bound to plasma protein and has a volume of distribution of about 10 liters. After oral or i.v. administration, apparent removal t½ is on the order of 5-8 hours. About 90% oral or i.v. the dose is excreted in the urine, with 50% of the dose excreted in the urine unchanged and another 30% as a 0-0 glucuronide.

Preclinical Safety Data Sheet

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Doesn’t matter.

Interaction

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