What are the active ingredients in DIUREX Max Water Caplets. How do DIUREX Max Water Caplets work. Can DIUREX Max Water Caplets be used for weight loss. Are there any side effects associated with DIUREX Max Water Caplets. How long can you safely use DIUREX Max Water Caplets.

DIUREX Max Water Caplets: Composition and Primary Function

DIUREX Max Water Caplets are a popular over-the-counter medication designed to address specific women’s health concerns. The primary active ingredient in these caplets is Pamabrom, a mild diuretic compound that bears similarities to caffeine in its molecular structure and effects.

What is Pamabrom?

Pamabrom is a unique compound that combines 8-bromotheophylline with 2-amino-2-methyl-1-propanol. This combination results in a substance that exhibits diuretic properties similar to caffeine but without the stimulant effects typically associated with caffeine consumption.

• Pamabrom dosage: Each DIUREX Max Water Caplet contains 50 mg of Pamabrom
• Function: Helps relieve temporary water weight gain and bloating
• Comparison to caffeine: Similar water-relieving activity without stimulation

The Primary Uses of DIUREX Max Water Caplets

DIUREX Max Water Caplets are specifically formulated to address a range of discomforts commonly experienced by women during their menstrual cycle. The primary uses include:

1. Relieving temporary water weight gain
2. Reducing bloating
3. Alleviating other discomforts associated with premenstrual and menstrual periods

Is there a specific timeframe for using DIUREX Max Water Caplets? According to the product labeling, it is recommended not to use DIUREX for more than 10 consecutive days without consulting a healthcare professional. This guideline ensures the safe and effective use of the product while minimizing potential risks associated with prolonged use.

Dosage and Administration of DIUREX Max Water Caplets

Proper dosage and administration are crucial for the safe and effective use of any medication, including DIUREX Max Water Caplets. The recommended dosage instructions are as follows:

• Take one caplet after breakfast with a full glass of water
• The dose may be repeated after 6 hours if needed
• Do not exceed 4 caplets in 24 hours

Why is it important to follow the dosage instructions carefully? Adhering to the recommended dosage helps ensure that you receive the intended benefits of the medication while minimizing the risk of potential side effects or complications. It’s always advisable to read and follow all product package label directions, uses, and warnings before use.

DIUREX Max Water Caplets and Weight Loss: Separating Fact from Fiction

A common question surrounding DIUREX Max Water Caplets is whether they can be used as a weight loss aid. It’s important to clarify the product’s intended use and potential effects on body weight.

Can DIUREX Max Water Caplets help with weight loss? While these caplets may lead to a temporary reduction in water weight, they are not designed or marketed as a weight loss product. Their primary function is to relieve temporary water weight gain and bloating associated with menstrual cycles.

It’s crucial to understand the difference between losing water weight and losing body fat. Water weight loss is temporary and typically returns once hydration levels normalize. For sustainable weight loss, a balanced diet and regular exercise are recommended.

Safety Considerations and Potential Interactions

When considering the use of any medication, including over-the-counter products like DIUREX Max Water Caplets, it’s essential to be aware of potential safety considerations and drug interactions.

Sulfa Drug Content

Do DIUREX Max Water Caplets contain sulfa drugs? No, these caplets do not contain any sulfa drug ingredients. This information is particularly important for individuals with sulfa allergies.

Interactions with Prescription Medications

Can DIUREX Max Water Caplets be used alongside prescription medications? It’s always recommended to consult with a healthcare professional before combining any over-the-counter product with prescription medications. This precaution helps prevent potential drug interactions that could affect the efficacy of either medication or lead to unwanted side effects.

Specific Use Cases and Considerations

While DIUREX Max Water Caplets are primarily marketed for menstrual-related discomforts, questions often arise about their use in other situations or by different demographics.

Use by Individuals Without Menstrual Cycles

Can DIUREX Max Water Caplets be used by those who no longer have menstrual periods? The product is specifically designed for menstrual-related issues. For any other use, it’s advisable to consult with a healthcare professional to determine if it’s appropriate and safe.

Use by Men

Is it safe for men to use DIUREX Max Water Caplets? While the product is marketed for menstrual-related discomforts, which primarily affect women, its use for other purposes or by men should be discussed with a healthcare provider. They can provide personalized advice based on individual health needs and potential risks.

Use for Edema in Extremities

Can DIUREX Max Water Caplets be used to reduce swelling in feet and ankles? While the product may have a diuretic effect, it’s not specifically indicated for this use. Swelling in extremities can be a sign of various health conditions, and it’s important to consult with a healthcare provider for proper diagnosis and treatment.

Comparing DIUREX Max Water Caplets to Other DIUREX Products

DIUREX offers a range of products designed to address various symptoms related to water retention and menstrual discomfort. One such product is DIUREX Water Pills + Pain Relief, which has a different formulation compared to DIUREX Max Water Caplets.

DIUREX Water Pills + Pain Relief: Composition and Use

What are the active ingredients in DIUREX Water Pills + Pain Relief? Each pill contains:

• 162.5 mg of magnesium salicylate
• 50 mg of caffeine

This formulation differs from DIUREX Max Water Caplets, which contain Pamabrom as the active ingredient. The addition of magnesium salicylate in DIUREX Water Pills + Pain Relief provides an analgesic effect, potentially offering relief from menstrual cramps in addition to addressing water retention.

Dosage Differences

How does the dosage of DIUREX Water Pills + Pain Relief compare to DIUREX Max Water Caplets? The recommended dosage for DIUREX Water Pills + Pain Relief is two pills every 4 to 6 hours, not to exceed eight pills per day. This differs from the dosage instructions for DIUREX Max Water Caplets, highlighting the importance of reading and following the specific instructions for each product.

Understanding these differences can help individuals choose the most appropriate product for their specific needs and symptoms. However, as with any medication, it’s advisable to consult with a healthcare professional before use, especially if you have any underlying health conditions or are taking other medications.

DIUREX Max | Alva-Amco

What are DIUREX Max Water Caplets used for?

DIUREX Max Water Caplets help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods.

What are the active ingredients in DIUREX Max Water Caplets?

Each DIUREX Max Water Caplet contains 50 mg of Pamabrom.

What is pamabrom?

Pamabrom is a mild diuretic ingredient that is similar to caffeine. It has the water-relieving activity of caffeine, without the stimulation of caffeine.

What is the dosage for DIUREX Max Water Caplets?

The dosage for DIUREX Max Water Caplets is one caplet after breakfast with a full glass of water. Dose may be repeated after 6 hours, not to exceed 4 caplets in 24 hours. Be sure to read all product package label Directions, Uses and Warnings and follow them carefully.

Do DIUREX Max Water Caplets contain any sulfa drugs?

No, DIUREX Max Water Caplets do not contain sulfa drug ingredients.

Do DIUREX Max Water Caplets help you lose weight?

DIUREX Max Water Caplets help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. We recommend that you ask your doctor or pharmacist before using DIUREX for a purpose other than that indicated on the product package labeling and follow his or her advice.

Do DIUREX Max Water Caplets “clean out your system”?

DIUREX Max Water Caplets help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. We recommend that you ask your doctor or pharmacist before using DIUREX for a purpose other than that indicated on the product package labeling and follow his or her advice.

Can I use DIUREX Max Water Caplets continuously?

DIUREX Max Water Caplets help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. The product package labeling states that you should not use DIUREX for more than 10 consecutive days without consulting your doctor.

Can I use DIUREX Max Water Caplets to remove the swelling in my feet and ankles?

DIUREX Max Water Caplets help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. We recommend that you ask your doctor or pharmacist before using DIUREX for a purpose other than that indicated on or in the product package labeling and follow his or her advice.

Can I use DIUREX Max Water Caplets with my prescription medication(s)?

You should ask your doctor or pharmacist if you can take DIUREX Max Water Caplets while you are using other medications.

I don’t have a period any more. Can I still use DIUREX Max Water Caplets?

DIUREX Max Water Caplets help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. We recommend that you ask your doctor or pharmacist before using DIUREX for a purpose other than that indicated on the product package labeling and follow his or her advice.

Can a man use DIUREX Max Water Caplets?

DIUREX Max Water Caplets help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. We recommend that you ask your doctor or pharmacist before using DIUREX for a purpose other than that indicated on the product package labeling and follow his or her advice.

DIUREX Water Pills + Pain Relief

What are DIUREX WATER PILLS used for?

DIUREX WATER PILLS help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods.

What are the active ingredients in DIUREX WATER PILLS?

Each DIUREX WATER PILL contains 162.5 mg of magnesium salicylate and 50 mg of caffeine.

What is the dosage for DIUREX WATER PILLS?

The dosage for DIUREX WATER PILLS is two pills every 4 to 6 hours, not to exceed eight pills per day. Be sure to read all label Directions, Uses and Warnings and follow them carefully.

Do DIUREX WATER PILLS contain any sulfa drugs?

No, DIUREX WATER PILLS do not contain sulfa drug ingredients.

Are there any side effects associated with DIUREX WATER PILLS?

Information regarding the side effects which may be associated with DIUREX WATER PILLS may be found in the Warnings and Directions sections of Drug Facts for DIUREX WATER PILLS. Drug Facts may be found on the back panel of the DIUREX WATER PILLS package or on this website.

Do DIUREX WATER PILLS help you lose weight?

DIUREX WATER PILLS help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. We recommend that you ask your doctor or pharmacist before using DIUREX for a purpose other than that indicated on the product package labeling and follow his or her advice.

Do DIUREX WATER PILLS “clean out your system”?

DIUREX WATER PILLS help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. We recommend that you ask your doctor or pharmacist before using DIUREX for a purpose other than that indicated on the product package labeling and follow his or her advice.

Can I use DIUREX WATER PILLS continuously?

DIUREX WATER PILLS help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. The product package labeling states that you should not use DIUREX for more than 10 consecutive days without consulting your doctor.

Can I use DIUREX WATER PILLS to remove the swelling in my feet and ankles?

DIUREX WATER PILLS help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. We recommend that you ask your doctor or pharmacist before using DIUREX for a purpose other than that indicated on or in the product package labeling and follow his or her advice.

Can I use DIUREX WATER PILLS with my prescription medications(s)?

You should ask your doctor or pharmacist if you can take DIUREX WATER PILLS while you are using other medications.

I don’t have a period any more. Can I still use DIUREX WATER PILLS?

DIUREX WATER PILLS help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. We recommend that you ask your doctor or pharmacist before using DIUREX for a purpose other than that indicated on the product package labeling and follow his or her advice.

Can a man use DIUREX WATER PILLS?

DIUREX WATER PILLS help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. We recommend that you ask your doctor or pharmacist before using DIUREX for a purpose other than that indicated on the product package labeling and follow his or her advice.

Will DIUREX WATER PILLS show up on a drug test?

We have not had reports of the active ingredients in DIUREX WATER PILLS showing up on a drug test. However, as indicated in or on the product package labeling, DIUREX WATER PILLS may turn your urine blue or blue-green, which may be an issue in a urine test.

Do DIUREX WATER PILLS make your urine blue?

As stated on or in the product package labeling, blue or blue-green tinted urine when using DIUREX WATER PILLS is a normal and temporary effect.

Diurex (Xipamide) – instructions for use, dosage, composition, analogues, side effects / Pillintrip

Page reviewed by pharmacist Olga Valerievna Fedorchenko Last update 2022-04-02

Top 20 medicines with the same ingredients: d – 1 A PharmaXipamid AbZXipamid StadaXipamid-ratiopharmAquaphorNeotriXipamid AAA-Pharma

Name of the drug

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Diurex (Xipamide)

Composition

Description Composition Diurex (Xipamide) is an automatic translation from the original language.
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Xipamide

Therapeutic indications

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For the treatment of hypertension, alone or as an adjunct to treatment with antihypertensive drugs.

For use as a diuretic.

Dosage and Administration

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1. Treatment of hypertension

Dosage:

Adults : 1 tablet (20 mg) per day as a single early morning dose. When using Diurex (Xipamide) in combination with other antihypertensive therapy, the same dose of 20 mg as a single early morning dose should be maintained.

Children : Dose not recommended.

Elderly : See Respect.

2. Use as a diuretic

Dosage :

Adults : At the initial stage of treatment, the usual dose is 2 tablets (40 mg) per day in a single early morning dose. Depending on the response of the patient, the dose may be reduced to 1 tablet per day when sufficient control of edema has been achieved. In resistant cases, higher doses may be used, up to 4 tablets per day (80 mg).

Children : Dose not recommended.

Elderly people : See “Respects”.

Contraindications

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Diurex (xipamide) is contraindicated in severe electrolyte deficiency, precoma associated with liver cirrhosis, severe renal failure, hypersensitivity to xipamide, untreated Addison’s disease, hypercalcemia, pre-existing hypovolemia, symptomatic hyperuricemia, pregnancy and lactation .

Special Warnings and Precautions

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In patients with liver disease, therapy with thiazide diuretics and related substances may cause hepatic encephalopathy. In this case, treatment with Diurex (Xipamide) should be stopped immediately.

Some cases of photosensitivity have been reported with the use of thiazide diuretics.

If a photosensitivity reaction occurs during treatment, xipamide should be discontinued. If re-administration of treatment cannot be avoided, the skin area exposed to sunlight or artificial UVA should be protected.

Pseudo-Bartter may occur in case of chronic abuse of diuretics.

Patients with rare hereditary fructose intolerance, glucose-galactose malabsorption, or sucrose-isomaltose intolerance should not take Diurex (Xipamide).

As with all antihypertensive agents, caution should be exercised in patients with severe coronary or cerebral arteriosclerosis.

An increased risk of urinary retention may occur in patients with prostatic hypertrophy.

Precautions for use of the drug:

Water and electrolyte balance:

Plasma sodium:

Plasma sodium should be monitored prior to initiation of therapy and at regular intervals during treatment. In principle, hyponatremia can occur with any diuretic treatment, with very serious complications. Since a decrease in plasma sodium levels may initially pass asymptomatically, regular monitoring is necessary; elderly patients and patients with cirrhosis of the liver should be carefully monitored (cf. adverse effects and overdose).

Potassium level:

As with other diuretics, hypokalemia may occur during long-term therapy with xipamide. Serum electrolytes (particularly potassium, sodium, calcium), bicarbonate, creatinine, urea, uric acid, and blood sugar should be monitored regularly. Potassium replacement may be required, especially in elderly patients with insufficient potassium intake.

Decreased potassium levels to the point of hypokalemia is the main risk of treatment with thiazide diuretics and closely related drugs. The occurrence of hypokalemia (plasma potassium level <3.4 mmol/l) should be avoided, especially in case of greater fluid loss (e.g. due to vomiting, diarrhea or intense sweating) and in risk groups, i.e. in elderly and / or malnourished patients and / or patients receiving treatment with several drugs, as well as in patients with cirrhosis of the liver and the formation of edema or ascites, moreover, in patients with coronary heart disease and patients with heart failure. In this group of patients, hypokalemia will also increase the cardiotoxicity of cardiac glycosides and the risk of cardiac dysrhythmia.

Hypovolemia or dehydration, as well as severe electrolyte or acid-base disturbances, must be corrected. This may require a temporary discontinuation of xipamide treatment.

Individuals with congenital or iatrogenic acquired long QT intervals are also at high risk. The presence of hypokalemia and bradycardia will contribute to the occurrence of severe arrhythmias, in particular the possible lethal pointe de torsade (polymorphic ventricular tachycardia).

All of the above cases require frequent monitoring of potassium levels, starting the first monitoring within the first week after starting therapy. Hypokalemia must be corrected.

Plasma calcium level:

Treatment with thiazide diuretics and related drugs may result in a decrease in urinary calcium excretion and a slight transient increase in plasma calcium levels. It is possible that the apparent hypercalcemia was due to a previous unexplored hyperparatriosis.

Xipamide therapy should be discontinued pending a possible study of parathyroid function.

Blood sugar level:

Especially in diabetic patients with concomitant hypokalemia, blood sugar levels should be carefully monitored.

Uric acid level:

Patients with hyperuricemia may have an increased tendency to acute gouty arthritis.

Renal function and diuretics:

Thiazide and related substances are only effective in normal or at least mild renal impairment (serum creatinine <25 mg/l or <220 Î1⁄4mol/l in adults ). In elderly patients, this serum creatinine value should be adjusted according to the age, weight and sex of the respective patient.

Hypovolemia caused by loss of water and sodium associated with diuretics at the beginning of therapy leads to a decrease in glomerular filtration rate. This can cause an increase in blood urea nitrogen (BUN) and serum creatinine. This temporary functional renal insufficiency remains without sequelae in healthy renal individuals, but may exacerbate pre-existing renal insufficiency.

In the event of treatment-resistant electrolyte decompensation, therapy should be discontinued.

Effects on ability to drive and use machines

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Xipamide may cause dizziness and electrolyte disturbances which may affect the patient’s concentration or alertness and may affect the patient’s ability to drive or operate machinery safely. This is especially true for initiation of treatment or dose changes. When affected, patients should not drive or operate a car.

Side effects

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The following side effects may occur when using thiazide diuretics and related drugs, including xipamide. With regard to clinical and chemical parameters, most adverse effects are dose dependent.

Rarely, anaphylactoid reactions may occur.

Latent diabetes mellitus may appear. In patients with diabetes, glucose levels may be increased.

At high doses, the risk of thrombosis and embolism is increased, especially in previous existing venous disorders.

Adverse events are listed below by system organ class and frequency. Frequencies are defined as: very common (> 1/l0), common (> 1/100 and <1/10), uncommon (> 1/1000 and <1/100), rare (> 1/10000 and <1/1000 ) and very rare (<1/1000), including available data cannot be known from.

Disorders of the blood and lymphatic system

Very rare: Thrombocytopenia, leukopenia, agranulocytosis, aplastic anemia (discontinuation of therapy)

Metabolic and nutritional disorders

Rare: Hyperlipidemia

Psychiatric disorders

General: Lethargy, restlessness, agitation

Nervous system disorders

Common: Headache, dizziness, dry mouth, fatigue, sweating

Visual disturbances

Rare: Minor visual disturbances, exacerbation of existing myopia (discontinuation of therapy)

Cardiac disorders

General: Palpitations

Vascular disorders

General: Orthostatic hypotension

Gastrointestinal disorders

Common: Upper abdominal discomfort, abdominal cramps, diarrhea, constipation

Rare: Hemorrhagic pancreatitis (discontinuation of therapy)

Hepatobiliary disorders

Rare: Acute cholecystitis in case of or pre-existing cholelithiasis (discontinuation of therapy)

Very rare: Jaundice (icterus)

Skin and subcutaneous tissue disorders

Uncommon: Photosensitive reactions

Rare: Allergic skin reactions (pruritus, erythema, urticaria) (discontinuation of therapy)

Musculoskeletal system and connective tissue

General : Muscle spasms/convulsions

Renal and urinary disorders

Very common: Hypokalemia which may become apparent with symptoms such as nausea, vomiting, ECG changes, glycoside hypersensitivity, arrhythmia or hypotension skeletal muscles.

General: Electrolyte and fluid disorders such as dehydration, hyponatremia, hypomagnesemia, hypochloremic alkalosis. Reversible increase in nitrogenous substances excreted in the urine (urea, creatinine), especially at the beginning of treatment. Elevated serum uric acid levels and triggering acute gouty arthritis in predisposed patients.

Very rare: Acute interstitial nephritis.

Therapy should be discontinued if:

– treatment-resistant electrolyte imbalance

– orthostatic regulatory disorders

– Hypersensitivity reactions

– Distinct gastrointestinal complaints

– Central nervous disorders

– Pancreatitis 9000 3

– changes in the blood (anemia, leukopenia, thrombocytopenia)

– acute cholecystitis

– occurrence of vasculitis

– exacerbation of existing myopia

Reporting suspected adverse reactions

Reporting suspected adverse reactions after drug approval is important. This allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are encouraged to report any suspected adverse reactions through the Yellow Card Scheme at:

www.mhra.gov.uk/yellowcard

Overdose

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There is no specific antidote for xipamide. Acute intoxications are manifested especially in violations of electrolytes and fluid balance (hyponatremia, hypokalemia). Clinical symptoms such as nausea, vomiting, drop in blood pressure, convulsions, dizziness, drowsiness, confusion, polyuria or oliguria and anuria (due to hypovolemia) may occur.

Emergency procedures: detoxification by administration of activated charcoal; subsequently restoration of the normal balance of water and electrolytes in a specialized center.

Gastric lavage or induced emesis may prevent further absorption. General measures should be aimed at maintaining blood pressure, restoring blood volume, and correcting electrolyte imbalances with appropriate intravenous infusion as needed.

Pharmacodynamics

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Xipamide is an antihypertensive diuretic that can be characterized pharmacologically as neither a thiazide nor a specific loop diuretic. Although structurally similar to chlorthalidone, it has a markedly different pharmacological profile, with its primary diuretic effect acting on the distal nephron.

As a diuretic, xipamide has been shown to be as effective as frachsemide in terms of daily urine output, but has a more gradual and prolonged effect.

Pharmacokinetics

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After a single oral dose of 20 mg xipamide, peak plasma concentrations of up to 3 µg/ml occur within 1 hour. Absolute bioavailability after oral administration is about 73%.

Xipamide is closely bound to plasma protein and has a volume of distribution of about 10 liters. After oral or i.v. administration, apparent removal t½ is on the order of 5-8 hours. About 90% oral or i.v. the dose is excreted in the urine, with 50% of the dose excreted in the urine unchanged and another 30% as a 0-0 glucuronide.

Preclinical Safety Data Sheet

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Doesn’t matter.

Interaction

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