What are DIUREX Max Water Caplets used for. How do DIUREX Water Pills differ from DIUREX Max. What are the active ingredients in DIUREX products. Can men use DIUREX Water Caplets. How long can you safely use DIUREX products.

Understanding DIUREX Max Water Caplets: Purpose and Composition

DIUREX Max Water Caplets are primarily designed to address temporary water weight gain, bloating, and other discomforts associated with premenstrual and menstrual periods. These caplets contain a single active ingredient: Pamabrom. Each caplet is formulated with 50 mg of this mild diuretic compound.

Pamabrom, the key component in DIUREX Max, is structurally similar to caffeine. It possesses water-relieving properties akin to caffeine but without the stimulatory effects. This unique characteristic makes it an effective choice for those seeking relief from water retention without experiencing the jitters often associated with caffeine consumption.

Recommended Dosage for DIUREX Max Water Caplets

The proper dosage for DIUREX Max Water Caplets is crucial for optimal results and safety. Users are advised to take one caplet after breakfast with a full glass of water. If necessary, this dose can be repeated after 6 hours. However, it’s important to note that the daily intake should not exceed 4 caplets within a 24-hour period.

• Take 1 caplet after breakfast with a full glass of water
• May repeat dose after 6 hours if needed
• Do not exceed 4 caplets in 24 hours
• Always read and follow the product package label carefully

DIUREX Water Pills: A Comprehensive Overview

While DIUREX Max Water Caplets focus solely on water retention relief, DIUREX Water Pills offer a dual-action formula. These pills are designed to address both water retention and pain associated with premenstrual and menstrual discomfort.

Active Ingredients in DIUREX Water Pills

Each DIUREX Water Pill contains two active ingredients:

1. 162.5 mg of magnesium salicylate
2. 50 mg of caffeine

The combination of these ingredients provides a more comprehensive approach to managing menstrual symptoms. Magnesium salicylate, a nonsteroidal anti-inflammatory drug (NSAID), helps alleviate pain, while caffeine acts as a diuretic to reduce water retention.

Dosage Instructions for DIUREX Water Pills

The recommended dosage for DIUREX Water Pills differs from that of DIUREX Max Water Caplets. Users should take two pills every 4 to 6 hours, with a maximum daily intake of eight pills. As with all medications, it’s crucial to carefully read and follow all label directions, uses, and warnings.

Safety Considerations and Potential Side Effects

While DIUREX products are generally well-tolerated, it’s essential to be aware of potential side effects and safety considerations. The DIUREX Water Pills package provides detailed information about possible side effects in the Warnings and Directions sections of the Drug Facts label.

Neither DIUREX Max Water Caplets nor DIUREX Water Pills contain sulfa drugs, which is beneficial for individuals with sulfa allergies. However, it’s always advisable to consult with a healthcare professional before starting any new medication, especially if you have pre-existing health conditions or are taking other medications.

Common Questions About DIUREX Products

Can DIUREX Products Be Used for Weight Loss?

While DIUREX products can help relieve temporary water weight gain, they are not intended for general weight loss purposes. These products are specifically designed to address water retention associated with menstrual cycles. For any use beyond the indicated purpose, it’s crucial to consult a doctor or pharmacist.

Do DIUREX Products “Clean Out Your System”?

DIUREX products are not designed to “clean out your system” in a general sense. Their primary function is to alleviate water retention and associated discomfort during menstrual periods. Any use beyond this intended purpose should be discussed with a healthcare professional.

Duration of Use and Special Considerations

The duration of use for DIUREX products is an important consideration. The product labeling for DIUREX Max Water Caplets advises against using the product for more than 10 consecutive days without consulting a doctor. This guideline helps prevent potential complications from prolonged use of diuretics.

For individuals without menstrual periods or for men considering using DIUREX products, it’s essential to consult with a healthcare provider. While these products are primarily marketed for menstrual-related symptoms, a doctor can advise on their appropriateness for other conditions involving water retention.

Interactions with Other Medications

When considering the use of DIUREX products alongside other medications, caution is advised. It’s crucial to consult with a doctor or pharmacist about potential interactions between DIUREX and any prescription medications you may be taking. This step helps ensure your safety and the effectiveness of all your medications.

Expanding on the Benefits and Limitations of DIUREX Products

While DIUREX products offer relief for specific symptoms, it’s important to understand their limitations. These products are not intended to treat underlying medical conditions that may cause persistent water retention or bloating. Chronic symptoms should always be evaluated by a healthcare professional to rule out more serious conditions.

DIUREX for Non-Menstrual Water Retention

Some individuals may wonder about using DIUREX products for water retention in other parts of the body, such as swollen feet and ankles. While the active ingredients in DIUREX can have a diuretic effect, it’s not recommended to use these products for such purposes without medical guidance. Swelling in extremities can be a sign of various health issues, including cardiovascular problems, and should be properly diagnosed by a healthcare provider.

Comparing DIUREX Max and DIUREX Water Pills

When choosing between DIUREX Max Water Caplets and DIUREX Water Pills, consider your specific symptoms:

• DIUREX Max: Focused solely on water retention relief
• DIUREX Water Pills: Addresses both water retention and pain

If you’re primarily dealing with bloating and water weight, DIUREX Max might be sufficient. However, if you’re also experiencing menstrual pain, DIUREX Water Pills could provide more comprehensive relief.

Understanding the Mechanism of Action

The effectiveness of DIUREX products lies in their ability to increase urine production, thereby reducing water retention in the body. Pamabrom, the active ingredient in DIUREX Max, works by inhibiting the reabsorption of water and electrolytes in the kidneys. This leads to increased urine output and, consequently, a reduction in water weight.

In DIUREX Water Pills, the addition of caffeine enhances this diuretic effect. Caffeine is known to stimulate urine production and increase metabolic rate. The magnesium salicylate component acts as an analgesic and anti-inflammatory agent, helping to alleviate menstrual cramps and other associated pains.

The Role of Proper Hydration

While it may seem counterintuitive, proper hydration is crucial when using diuretic products like DIUREX. Adequate water intake helps maintain the body’s fluid balance and supports the elimination of excess water. It’s recommended to drink plenty of water throughout the day when using these products to prevent dehydration and support their effectiveness.

Lifestyle Considerations When Using DIUREX Products

To maximize the benefits of DIUREX products and manage menstrual symptoms effectively, consider incorporating these lifestyle habits:

1. Balanced diet: Reduce salt intake to minimize water retention
2. Regular exercise: Light to moderate activity can help alleviate bloating and improve circulation
3. Stress management: Practice relaxation techniques to reduce stress-related water retention
4. Adequate sleep: Proper rest can help regulate hormones and reduce bloating

These lifestyle modifications, when combined with DIUREX products, can provide a more holistic approach to managing menstrual discomfort and water retention.

Potential Alternatives to DIUREX Products

While DIUREX products are effective for many individuals, some may prefer natural alternatives or different approaches to managing menstrual symptoms and water retention. Some options to consider include:

• Herbal diuretics: Dandelion tea, green tea, or parsley
• Dietary changes: Increasing potassium-rich foods and reducing sodium intake
• Compression garments: For localized swelling in extremities
• Prescription diuretics: For more severe cases, under medical supervision

It’s important to note that the effectiveness and safety of these alternatives can vary, and they should be discussed with a healthcare provider before implementation.

Long-Term Considerations and Regular Health Check-ups

While DIUREX products can provide relief for temporary water retention and menstrual discomfort, it’s crucial to address any persistent symptoms with a healthcare provider. Regular check-ups can help identify underlying conditions that may be contributing to chronic water retention or menstrual irregularities.

Additionally, long-term use of any medication, including over-the-counter products like DIUREX, should be monitored by a healthcare professional. This ensures that the benefits continue to outweigh any potential risks and that the treatment remains appropriate for your individual health needs.

Monitoring for Side Effects

When using DIUREX products, it’s important to be aware of potential side effects and report any unusual symptoms to your healthcare provider. While these products are generally well-tolerated, some individuals may experience:

• Electrolyte imbalances
• Dehydration
• Stomach upset
• Headaches

If you experience any of these symptoms or other concerning effects, discontinue use and consult with a healthcare professional.

The Future of Menstrual Symptom Management

As research in women’s health continues to advance, new approaches to managing menstrual symptoms and water retention may emerge. While products like DIUREX have been reliable options for many years, ongoing studies are exploring novel treatments that may offer even more targeted relief with fewer side effects.

Staying informed about these developments and discussing them with your healthcare provider can help ensure that you’re always using the most appropriate and effective treatments for your individual needs. Remember that what works best can change over time, and regular reassessment of your menstrual health management strategy is key to maintaining optimal well-being.

In conclusion, DIUREX products offer specific solutions for temporary water retention and menstrual discomfort. By understanding their proper use, potential benefits, and limitations, individuals can make informed decisions about incorporating these products into their menstrual health management plan. Always prioritize open communication with healthcare providers and stay attuned to your body’s responses to ensure the safest and most effective approach to managing your menstrual health.

DIUREX Max | Alva-Amco

What are DIUREX Max Water Caplets used for?

DIUREX Max Water Caplets help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods.

What are the active ingredients in DIUREX Max Water Caplets?

Each DIUREX Max Water Caplet contains 50 mg of Pamabrom.

What is pamabrom?

Pamabrom is a mild diuretic ingredient that is similar to caffeine. It has the water-relieving activity of caffeine, without the stimulation of caffeine.

What is the dosage for DIUREX Max Water Caplets?

The dosage for DIUREX Max Water Caplets is one caplet after breakfast with a full glass of water. Dose may be repeated after 6 hours, not to exceed 4 caplets in 24 hours. Be sure to read all product package label Directions, Uses and Warnings and follow them carefully.

Do DIUREX Max Water Caplets contain any sulfa drugs?

No, DIUREX Max Water Caplets do not contain sulfa drug ingredients.

Do DIUREX Max Water Caplets help you lose weight?

DIUREX Max Water Caplets help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. We recommend that you ask your doctor or pharmacist before using DIUREX for a purpose other than that indicated on the product package labeling and follow his or her advice.

Do DIUREX Max Water Caplets “clean out your system”?

DIUREX Max Water Caplets help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. We recommend that you ask your doctor or pharmacist before using DIUREX for a purpose other than that indicated on the product package labeling and follow his or her advice.

Can I use DIUREX Max Water Caplets continuously?

DIUREX Max Water Caplets help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. The product package labeling states that you should not use DIUREX for more than 10 consecutive days without consulting your doctor.

Can I use DIUREX Max Water Caplets to remove the swelling in my feet and ankles?

DIUREX Max Water Caplets help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. We recommend that you ask your doctor or pharmacist before using DIUREX for a purpose other than that indicated on or in the product package labeling and follow his or her advice.

Can I use DIUREX Max Water Caplets with my prescription medication(s)?

You should ask your doctor or pharmacist if you can take DIUREX Max Water Caplets while you are using other medications.

I don’t have a period any more. Can I still use DIUREX Max Water Caplets?

DIUREX Max Water Caplets help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. We recommend that you ask your doctor or pharmacist before using DIUREX for a purpose other than that indicated on the product package labeling and follow his or her advice.

Can a man use DIUREX Max Water Caplets?

DIUREX Max Water Caplets help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. We recommend that you ask your doctor or pharmacist before using DIUREX for a purpose other than that indicated on the product package labeling and follow his or her advice.

DIUREX Water Pills + Pain Relief

What are DIUREX WATER PILLS used for?

DIUREX WATER PILLS help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods.

What are the active ingredients in DIUREX WATER PILLS?

Each DIUREX WATER PILL contains 162.5 mg of magnesium salicylate and 50 mg of caffeine.

What is the dosage for DIUREX WATER PILLS?

The dosage for DIUREX WATER PILLS is two pills every 4 to 6 hours, not to exceed eight pills per day. Be sure to read all label Directions, Uses and Warnings and follow them carefully.

Do DIUREX WATER PILLS contain any sulfa drugs?

No, DIUREX WATER PILLS do not contain sulfa drug ingredients.

Are there any side effects associated with DIUREX WATER PILLS?

Information regarding the side effects which may be associated with DIUREX WATER PILLS may be found in the Warnings and Directions sections of Drug Facts for DIUREX WATER PILLS. Drug Facts may be found on the back panel of the DIUREX WATER PILLS package or on this website.

Do DIUREX WATER PILLS help you lose weight?

DIUREX WATER PILLS help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. We recommend that you ask your doctor or pharmacist before using DIUREX for a purpose other than that indicated on the product package labeling and follow his or her advice.

Do DIUREX WATER PILLS “clean out your system”?

DIUREX WATER PILLS help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. We recommend that you ask your doctor or pharmacist before using DIUREX for a purpose other than that indicated on the product package labeling and follow his or her advice.

Can I use DIUREX WATER PILLS continuously?

DIUREX WATER PILLS help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. The product package labeling states that you should not use DIUREX for more than 10 consecutive days without consulting your doctor.

Can I use DIUREX WATER PILLS to remove the swelling in my feet and ankles?

DIUREX WATER PILLS help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. We recommend that you ask your doctor or pharmacist before using DIUREX for a purpose other than that indicated on or in the product package labeling and follow his or her advice.

Can I use DIUREX WATER PILLS with my prescription medications(s)?

You should ask your doctor or pharmacist if you can take DIUREX WATER PILLS while you are using other medications.

I don’t have a period any more. Can I still use DIUREX WATER PILLS?

DIUREX WATER PILLS help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. We recommend that you ask your doctor or pharmacist before using DIUREX for a purpose other than that indicated on the product package labeling and follow his or her advice.

Can a man use DIUREX WATER PILLS?

DIUREX WATER PILLS help relieve temporary water weight gain, bloating and other discomforts associated with the premenstrual and menstrual periods. We recommend that you ask your doctor or pharmacist before using DIUREX for a purpose other than that indicated on the product package labeling and follow his or her advice.

Will DIUREX WATER PILLS show up on a drug test?

We have not had reports of the active ingredients in DIUREX WATER PILLS showing up on a drug test. However, as indicated in or on the product package labeling, DIUREX WATER PILLS may turn your urine blue or blue-green, which may be an issue in a urine test.

Do DIUREX WATER PILLS make your urine blue?

As stated on or in the product package labeling, blue or blue-green tinted urine when using DIUREX WATER PILLS is a normal and temporary effect.

Diurex (Xipamide) – instructions for use, dosage, composition, analogues, side effects / Pillintrip

Page reviewed by pharmacist Olga Valerievna Fedorchenko Last update 2022-04-02

Top 20 medicines with the same ingredients: d – 1 A PharmaXipamid AbZXipamid StadaXipamid-ratiopharmAquaphorNeotriXipamid AAA-Pharma

Name of the drug

Description The name of the drug Diurex (Xipamide) is an automatic translation from the original language.
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Diurex (Xipamide)

Composition

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Xipamide

Therapeutic indications

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For the treatment of hypertension, alone or as an adjunct to treatment with antihypertensive drugs.

For use as a diuretic.

Dosage and Administration

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1. Treatment of hypertension

Dosage:

Adults : 1 tablet (20 mg) per day as a single early morning dose. When using Diurex (Xipamide) in combination with other antihypertensive therapy, the same dose of 20 mg as a single early morning dose should be maintained.

Children : Dose not recommended.

Elderly : See Respect.

2. Use as a diuretic

Dosage :

Adults : At the initial stage of treatment, the usual dose is 2 tablets (40 mg) per day in a single early morning dose. Depending on the response of the patient, the dose may be reduced to 1 tablet per day when sufficient control of edema has been achieved. In resistant cases, higher doses may be used, up to 4 tablets per day (80 mg).

Children : Dose not recommended.

Elderly people : See “Respects”.

Contraindications

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Diurex (xipamide) is contraindicated in severe electrolyte deficiency, precoma associated with liver cirrhosis, severe renal failure, hypersensitivity to xipamide, untreated Addison’s disease, hypercalcemia, pre-existing hypovolemia, symptomatic hyperuricemia, pregnancy and lactation .

Special Warnings and Precautions

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In patients with liver disease, therapy with thiazide diuretics and related substances may cause hepatic encephalopathy. In this case, treatment with Diurex (Xipamide) should be stopped immediately.

Some cases of photosensitivity have been reported with the use of thiazide diuretics.

If a photosensitivity reaction occurs during treatment, xipamide should be discontinued. If re-administration of treatment cannot be avoided, the skin area exposed to sunlight or artificial UVA should be protected.

Pseudo-Bartter may occur in case of chronic abuse of diuretics.

Patients with rare hereditary fructose intolerance, glucose-galactose malabsorption, or sucrose-isomaltose intolerance should not take Diurex (Xipamide).

As with all antihypertensive agents, caution should be exercised in patients with severe coronary or cerebral arteriosclerosis.

An increased risk of urinary retention may occur in patients with prostatic hypertrophy.

Precautions for use of the drug:

Water and electrolyte balance:

Plasma sodium:

Plasma sodium should be monitored prior to initiation of therapy and at regular intervals during treatment. In principle, hyponatremia can occur with any diuretic treatment, with very serious complications. Since a decrease in plasma sodium levels may initially pass asymptomatically, regular monitoring is necessary; elderly patients and patients with cirrhosis of the liver should be carefully monitored (cf. adverse effects and overdose).

Potassium level:

As with other diuretics, hypokalemia may occur during long-term therapy with xipamide. Serum electrolytes (particularly potassium, sodium, calcium), bicarbonate, creatinine, urea, uric acid, and blood sugar should be monitored regularly. Potassium replacement may be required, especially in elderly patients with insufficient potassium intake.

Decreased potassium levels to the point of hypokalemia is the main risk of treatment with thiazide diuretics and closely related drugs. The occurrence of hypokalemia (plasma potassium level <3.4 mmol/l) should be avoided, especially in case of greater fluid loss (e.g. due to vomiting, diarrhea or intense sweating) and in risk groups, i.e. in elderly and / or malnourished patients and / or patients receiving treatment with several drugs, as well as in patients with cirrhosis of the liver and the formation of edema or ascites, moreover, in patients with coronary heart disease and patients with heart failure. In this group of patients, hypokalemia will also increase the cardiotoxicity of cardiac glycosides and the risk of cardiac dysrhythmia.

Hypovolemia or dehydration, as well as severe electrolyte or acid-base disturbances, must be corrected. This may require a temporary discontinuation of xipamide treatment.

Individuals with congenital or iatrogenic acquired long QT intervals are also at high risk. The presence of hypokalemia and bradycardia will contribute to the occurrence of severe arrhythmias, in particular the possible lethal pointe de torsade (polymorphic ventricular tachycardia).

All of the above cases require frequent monitoring of potassium levels, starting the first monitoring within the first week after starting therapy. Hypokalemia must be corrected.

Plasma calcium level:

Treatment with thiazide diuretics and related drugs may result in a decrease in urinary calcium excretion and a slight transient increase in plasma calcium levels. It is possible that the apparent hypercalcemia was due to a previous unexplored hyperparatriosis.

Xipamide therapy should be discontinued pending a possible study of parathyroid function.

Blood sugar level:

Especially in diabetic patients with concomitant hypokalemia, blood sugar levels should be carefully monitored.

Uric acid level:

Patients with hyperuricemia may have an increased tendency to acute gouty arthritis.

Renal function and diuretics:

Thiazide and related substances are only effective in normal or at least mild renal impairment (serum creatinine <25 mg/l or <220 Î1⁄4mol/l in adults ). In elderly patients, this serum creatinine value should be adjusted according to the age, weight and sex of the respective patient.

Hypovolemia caused by loss of water and sodium associated with diuretics at the beginning of therapy leads to a decrease in glomerular filtration rate. This can cause an increase in blood urea nitrogen (BUN) and serum creatinine. This temporary functional renal insufficiency remains without sequelae in healthy renal individuals, but may exacerbate pre-existing renal insufficiency.

In the event of treatment-resistant electrolyte decompensation, therapy should be discontinued.

Effects on ability to drive and use machines

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Xipamide may cause dizziness and electrolyte disturbances which may affect the patient’s concentration or alertness and may affect the patient’s ability to drive or operate machinery safely. This is especially true for initiation of treatment or dose changes. When affected, patients should not drive or operate a car.

Side effects

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The following side effects may occur when using thiazide diuretics and related drugs, including xipamide. With regard to clinical and chemical parameters, most adverse effects are dose dependent.

Rarely, anaphylactoid reactions may occur.

Latent diabetes mellitus may appear. In patients with diabetes, glucose levels may be increased.

At high doses, the risk of thrombosis and embolism is increased, especially in previous existing venous disorders.

Adverse events are listed below by system organ class and frequency. Frequencies are defined as: very common (> 1/l0), common (> 1/100 and <1/10), uncommon (> 1/1000 and <1/100), rare (> 1/10000 and <1/1000 ) and very rare (<1/1000), including available data cannot be known from.

Disorders of the blood and lymphatic system

Very rare: Thrombocytopenia, leukopenia, agranulocytosis, aplastic anemia (discontinuation of therapy)

Metabolic and nutritional disorders

Rare: Hyperlipidemia

Psychiatric disorders

General: Lethargy, restlessness, agitation

Nervous system disorders

Common: Headache, dizziness, dry mouth, fatigue, sweating

Visual disturbances

Rare: Minor visual disturbances, exacerbation of existing myopia (discontinuation of therapy)

Cardiac disorders

General: Palpitations

Vascular disorders

General: Orthostatic hypotension

Gastrointestinal disorders

Common: Upper abdominal discomfort, abdominal cramps, diarrhea, constipation

Rare: Hemorrhagic pancreatitis (discontinuation of therapy)

Hepatobiliary disorders

Rare: Acute cholecystitis in case of or pre-existing cholelithiasis (discontinuation of therapy)

Very rare: Jaundice (icterus)

Skin and subcutaneous tissue disorders

Uncommon: Photosensitive reactions

Rare: Allergic skin reactions (pruritus, erythema, urticaria) (discontinuation of therapy)

Musculoskeletal system and connective tissue

General : Muscle spasms/convulsions

Renal and urinary disorders

Very common: Hypokalemia which may become apparent with symptoms such as nausea, vomiting, ECG changes, glycoside hypersensitivity, arrhythmia or hypotension skeletal muscles.

General: Electrolyte and fluid disorders such as dehydration, hyponatremia, hypomagnesemia, hypochloremic alkalosis. Reversible increase in nitrogenous substances excreted in the urine (urea, creatinine), especially at the beginning of treatment. Elevated serum uric acid levels and triggering acute gouty arthritis in predisposed patients.

Very rare: Acute interstitial nephritis.

Therapy should be discontinued if:

– treatment-resistant electrolyte imbalance

– orthostatic regulatory disorders

– Hypersensitivity reactions

– Distinct gastrointestinal complaints

– Central nervous disorders

– Pancreatitis 9000 3

– changes in the blood (anemia, leukopenia, thrombocytopenia)

– acute cholecystitis

– occurrence of vasculitis

– exacerbation of existing myopia

Reporting suspected adverse reactions

Reporting suspected adverse reactions after drug approval is important. This allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are encouraged to report any suspected adverse reactions through the Yellow Card Scheme at:

www.mhra.gov.uk/yellowcard

Overdose

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There is no specific antidote for xipamide. Acute intoxications are manifested especially in violations of electrolytes and fluid balance (hyponatremia, hypokalemia). Clinical symptoms such as nausea, vomiting, drop in blood pressure, convulsions, dizziness, drowsiness, confusion, polyuria or oliguria and anuria (due to hypovolemia) may occur.

Emergency procedures: detoxification by administration of activated charcoal; subsequently restoration of the normal balance of water and electrolytes in a specialized center.

Gastric lavage or induced emesis may prevent further absorption. General measures should be aimed at maintaining blood pressure, restoring blood volume, and correcting electrolyte imbalances with appropriate intravenous infusion as needed.

Pharmacodynamics

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Xipamide is an antihypertensive diuretic that can be characterized pharmacologically as neither a thiazide nor a specific loop diuretic. Although structurally similar to chlorthalidone, it has a markedly different pharmacological profile, with its primary diuretic effect acting on the distal nephron.

As a diuretic, xipamide has been shown to be as effective as frachsemide in terms of daily urine output, but has a more gradual and prolonged effect.

Pharmacokinetics

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After a single oral dose of 20 mg xipamide, peak plasma concentrations of up to 3 µg/ml occur within 1 hour. Absolute bioavailability after oral administration is about 73%.

Xipamide is closely bound to plasma protein and has a volume of distribution of about 10 liters. After oral or i.v. administration, apparent removal t½ is on the order of 5-8 hours. About 90% oral or i.v. the dose is excreted in the urine, with 50% of the dose excreted in the urine unchanged and another 30% as a 0-0 glucuronide.

Preclinical Safety Data Sheet

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Doesn’t matter.

Interaction

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