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What is methocarbamol 750 mg tablets used for. Methocarbamol 750 mg: Uses, Side Effects, and Precautions for Muscle Pain Relief

What are the primary uses of methocarbamol 750 mg tablets. How does methocarbamol work to relieve muscle spasms and pain. What are the potential side effects and precautions associated with methocarbamol use. How should methocarbamol be taken for optimal effectiveness and safety.

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Understanding Methocarbamol: A Powerful Muscle Relaxant

Methocarbamol is a widely prescribed medication used primarily for the treatment of muscle spasms and associated pain. This powerful muscle relaxant works by helping to relax muscles, providing relief from discomfort and improving mobility. Typically, methocarbamol is used in conjunction with rest, physical therapy, and other treatments to maximize its effectiveness in managing musculoskeletal conditions.

Key Features of Methocarbamol 750 mg Tablets

  • Prescription-only medication
  • Available in 750 mg tablet form
  • Classified as a muscle relaxant
  • Often used alongside other therapies
  • Helps alleviate muscle spasms and pain

The Mechanism of Action: How Methocarbamol Works

Methocarbamol’s effectiveness in treating muscle spasms and pain lies in its ability to influence the central nervous system. By acting on the brain and spinal cord, this medication helps to reduce the sensation of pain and relax tense muscles. This dual action makes it particularly useful for conditions where muscle tension and pain are closely intertwined.

Do you know how quickly methocarbamol takes effect? The onset of action for methocarbamol can vary, but many patients report feeling relief within 30 minutes to an hour after taking the medication. However, it’s important to note that the full therapeutic effect may take several days of consistent use to achieve.

Proper Usage and Dosage Guidelines

Taking methocarbamol correctly is crucial for achieving optimal results and minimizing the risk of side effects. The medication can be taken orally with or without food, as directed by a healthcare provider. It’s essential to follow the prescribed dosage and not exceed the recommended amount or duration of use.

Typical Dosage Instructions

  1. Take as prescribed by your doctor
  2. Do not increase dosage without medical advice
  3. Avoid using for longer than recommended
  4. Dosage may be adjusted based on individual response
  5. Inform your doctor if symptoms persist or worsen

Is it safe to take methocarbamol long-term? While methocarbamol can be effective for short-term use, long-term usage should be carefully monitored by a healthcare professional. Extended use may increase the risk of side effects and potentially lead to dependence in some individuals.

Potential Side Effects and Monitoring

As with any medication, methocarbamol can cause side effects, although not everyone experiences them. It’s important to be aware of potential adverse reactions and to report any concerning symptoms to a healthcare provider promptly.

Common Side Effects

  • Drowsiness
  • Dizziness
  • Lightheadedness
  • Stomach upset
  • Nausea or vomiting
  • Blurred vision

Can methocarbamol cause serious side effects? While rare, serious side effects can occur. These may include severe nausea/vomiting, fainting, slow heartbeat, yellowing of eyes/skin, and mental/mood changes. If you experience any of these symptoms, seek medical attention immediately.

Precautions and Considerations Before Use

Before starting methocarbamol treatment, it’s crucial to inform your healthcare provider about your complete medical history, including any allergies, liver conditions, or other health concerns. This information helps ensure that methocarbamol is safe and appropriate for your individual needs.

Important Considerations

  • Inform your doctor of all medications and supplements you’re taking
  • Discuss any history of liver disease
  • Avoid alcohol and marijuana while using methocarbamol
  • Use caution when operating machinery or driving
  • Consult a healthcare provider if pregnant or breastfeeding

Are there any specific groups that should use methocarbamol with caution? Older adults may be more sensitive to the side effects of methocarbamol, particularly confusion, dizziness, and drowsiness. These effects can increase the risk of falls, so extra caution is advised for this population.

Drug Interactions and Potential Risks

Methocarbamol can interact with various medications and substances, potentially altering its effectiveness or increasing the risk of side effects. It’s essential to inform your healthcare provider about all the products you use, including prescription drugs, over-the-counter medications, and herbal supplements.

Common Drug Interactions

  • Opioid pain relievers
  • Cough suppressants containing codeine or hydrocodone
  • Alcohol
  • Marijuana
  • Sleep aids or anti-anxiety medications
  • Other muscle relaxants
  • Antihistamines

How can you minimize the risk of drug interactions with methocarbamol? Always consult with your healthcare provider or pharmacist before starting any new medication or supplement while taking methocarbamol. They can provide guidance on potential interactions and help you create a safe and effective treatment plan.

Recognizing and Responding to Overdose

While rare, methocarbamol overdose can occur, especially if the medication is taken in larger amounts than prescribed or combined with other substances that enhance its effects. Recognizing the signs of overdose and knowing how to respond can be life-saving.

Symptoms of Methocarbamol Overdose

  • Severe drowsiness
  • Confusion
  • Blurred vision
  • Nausea and vomiting
  • Seizures (in severe cases)
  • Difficulty breathing
  • Loss of consciousness

What should you do if you suspect a methocarbamol overdose? If someone shows serious symptoms such as difficulty breathing or loss of consciousness, call emergency services immediately. For less severe symptoms, contact a poison control center for guidance. In the United States, you can reach the national poison control center at 1-800-222-1222.

Long-Term Considerations and Alternative Treatments

While methocarbamol can be highly effective for short-term relief of muscle spasms and pain, it’s important to consider long-term management strategies and alternative treatments. This is particularly relevant for chronic conditions or recurring muscle issues.

Complementary Approaches to Muscle Pain Management

  • Physical therapy
  • Massage therapy
  • Acupuncture
  • Yoga and stretching exercises
  • Heat and cold therapy
  • Stress reduction techniques
  • Ergonomic adjustments

Can lifestyle changes help reduce the need for methocarbamol? Many individuals find that incorporating regular exercise, maintaining good posture, and practicing stress management techniques can significantly reduce muscle tension and pain. These lifestyle modifications may help decrease reliance on medications like methocarbamol over time.

Is methocarbamol suitable for all types of muscle pain? While methocarbamol is effective for many forms of muscle spasms and pain, it may not be the best choice for all conditions. Some muscular issues may respond better to other treatments or require a multifaceted approach. Always consult with a healthcare provider to determine the most appropriate treatment plan for your specific situation.

Monitoring and Adjusting Treatment

Effective use of methocarbamol often involves ongoing monitoring and potential adjustments to the treatment plan. Regular check-ins with your healthcare provider can help ensure that the medication continues to provide the desired benefits while minimizing any potential risks or side effects.

Key Aspects of Treatment Monitoring

  • Regular assessment of symptom improvement
  • Evaluation of side effects
  • Consideration of dosage adjustments
  • Exploration of complementary therapies
  • Discussion of long-term management strategies

How often should you follow up with your doctor when taking methocarbamol? The frequency of follow-up appointments can vary depending on individual circumstances, but generally, it’s advisable to have an initial follow-up within a few weeks of starting the medication. Subsequent check-ins may be scheduled based on your response to treatment and any ongoing concerns.

What signs indicate that your methocarbamol treatment may need adjustment? If you experience persistent side effects, inadequate pain relief, or find that the medication’s effectiveness is diminishing over time, it may be time to discuss potential adjustments with your healthcare provider. They can help determine if a change in dosage, alternative treatments, or a different approach altogether might be more beneficial.

Special Considerations for Specific Populations

Certain groups may require special considerations when using methocarbamol. These populations may be at higher risk for side effects or may need modified treatment approaches to ensure safe and effective use of the medication.

Populations Requiring Special Attention

  • Elderly patients
  • Pregnant or breastfeeding women
  • Individuals with liver disease
  • Patients with a history of substance abuse
  • Those with certain medical conditions (e.g., myasthenia gravis)

How does age affect the use of methocarbamol? Older adults may be more sensitive to the effects of methocarbamol and may require lower doses to achieve the desired therapeutic effect. Additionally, the increased risk of falls due to dizziness or drowsiness is a particular concern in this population, necessitating careful monitoring and possibly additional fall prevention strategies.

Is methocarbamol safe during pregnancy and breastfeeding? The safety of methocarbamol during pregnancy and breastfeeding is not fully established. While some studies suggest minimal risk, the potential benefits must be carefully weighed against any possible risks. Pregnant or breastfeeding individuals should consult closely with their healthcare provider before using methocarbamol.

Understanding Laboratory Test Interactions

An important but often overlooked aspect of methocarbamol use is its potential to interfere with certain laboratory tests. This interaction can lead to false test results, potentially impacting medical diagnoses or treatment decisions.

Tests Affected by Methocarbamol

  • Vanillylmandelic acid (VMA) urine screening test
  • 5-hydroxyindoleacetic acid (5-HIAA) urine screening test
  • Other tests that rely on similar chemical reactions

Why is it important to inform laboratory personnel about methocarbamol use? Notifying laboratory staff and healthcare providers about your use of methocarbamol allows them to interpret test results accurately and avoid potential misdiagnoses. In some cases, alternative testing methods may be recommended to ensure reliable results.

How long does methocarbamol stay in your system and potentially affect test results? The elimination half-life of methocarbamol is typically around 1-2 hours, but it can vary between individuals. Generally, the drug is cleared from the system within 24-48 hours after the last dose. However, for accurate laboratory testing, it’s best to consult with your healthcare provider about the appropriate timing of tests in relation to your methocarbamol use.

Methocarbamol in Combination Therapies

While methocarbamol is often effective on its own, it may sometimes be prescribed as part of a combination therapy approach. Understanding how methocarbamol can be used alongside other treatments can help optimize pain management and overall treatment outcomes.

Common Combination Approaches

  • Methocarbamol with non-steroidal anti-inflammatory drugs (NSAIDs)
  • Combination with physical therapy exercises
  • Use alongside topical pain relievers
  • Integration with cognitive behavioral therapy for chronic pain
  • Pairing with other muscle relaxants or pain medications in specific cases

Can combining methocarbamol with other treatments enhance its effectiveness? In many cases, a multimodal approach that combines methocarbamol with other therapies can provide more comprehensive pain relief and faster recovery. For example, using methocarbamol to reduce muscle spasms may allow for more effective physical therapy sessions, leading to improved long-term outcomes.

What precautions should be taken when using methocarbamol in combination therapies? When combining treatments, it’s crucial to be aware of potential drug interactions and cumulative side effects. Always consult with your healthcare provider before adding new treatments to your regimen, and be sure to report any unusual symptoms or changes in your condition promptly.

Patient Education and Self-Management Strategies

Empowering patients with knowledge about methocarbamol and teaching self-management strategies can significantly enhance treatment outcomes. Understanding how to use the medication effectively, recognize potential issues, and implement complementary self-care techniques can lead to better pain management and overall well-being.

Key Elements of Patient Education

  • Proper medication administration and timing
  • Recognition of side effects and when to seek medical attention
  • Importance of adherence to prescribed dosage and duration
  • Integration of non-pharmacological pain management techniques
  • Strategies for preventing muscle spasms and pain

How can patients actively participate in their treatment plan while using methocarbamol? Patients can take an active role by keeping a symptom and medication diary, practicing prescribed exercises or stretches, implementing stress reduction techniques, and maintaining open communication with their healthcare provider about their progress and any concerns.

What lifestyle modifications can complement methocarbamol treatment? Adopting a healthy lifestyle that includes regular exercise, proper nutrition, adequate sleep, and stress management can significantly enhance the effectiveness of methocarbamol and contribute to overall musculoskeletal health. These modifications may also help reduce the need for medication over time.

Future Perspectives and Research Directions

As medical science continues to advance, ongoing research into muscle relaxants like methocarbamol may lead to new insights and treatment approaches. Staying informed about emerging research and potential developments can help patients and healthcare providers make informed decisions about pain management strategies.

Areas of Current and Future Research

  • Development of new formulations or delivery methods
  • Investigation of long-term effects and safety profiles
  • Exploration of combination therapies for enhanced efficacy
  • Studies on methocarbamol’s effectiveness in specific conditions
  • Research into personalized medicine approaches for muscle pain treatment

Are there any promising alternatives to methocarbamol on the horizon? While methocarbamol remains a valuable treatment option, researchers are continuously exploring new compounds and approaches for muscle pain management. Some areas of interest include novel muscle relaxants with fewer side effects, targeted therapies that act on specific pain pathways, and advanced physical therapy techniques enhanced by technology.

How might future research impact the use of methocarbamol in clinical practice? Ongoing studies may lead to more refined dosing guidelines, improved understanding of long-term effects, and potentially new indications for methocarbamol use. Additionally, research into personalized medicine approaches may help healthcare providers tailor treatment plans more effectively to individual patient needs and characteristics.

Methocarbamol Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

Methocarbamol is used to treat muscle spasms/pain. It is usually used along with rest, physical therapy, and other treatment. It works by helping to relax the muscles.

How to use Methocarbamol

Take this medication by mouth with or without food as directed by your doctor. Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.

The dosage is based on your medical condition and response to treatment.

Tell your doctor if your condition does not improve or if it worsens.

Side Effects

Drowsiness, dizziness, lightheadedness, stomach upset, nausea/vomiting, or blurred vision may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: nausea/vomiting that doesn’t stop, fainting, slow heartbeat, yellowing eyes/skin, mental/mood changes (such as confusion, forgetfulness).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking methocarbamol, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease.

This drug may make you dizzy or drowsy or blur your vision. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially confusion, dizziness, or drowsiness. These side effects can increase the risk of falling.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), other muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).

Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

This medication may interfere with certain laboratory tests (including VMA or 5-HIAA urine screening test), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Does Methocarbamol interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe drowsiness/dizziness, seizures, loss of consciousness.

Do not share this medication with others.

This medication has been prescribed for your current condition only. Do not use it later for another condition unless your doctor directs you to do so. A different medication may be necessary in that case.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

methocarbamol 750 mg tablet

Color: whiteShape: oblongImprint: H 115

This medicine is a white, oblong, tablet imprinted with “H” and “115”.

methocarbamol 750 mg tablet

Color: orangeShape: oblongImprint: B135

This medicine is a white, oblong, tablet imprinted with “H” and “115”.

methocarbamol 500 mg tablet

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This medicine is a white, oblong, tablet imprinted with “H” and “115”.

methocarbamol 750 mg tablet

Color: whiteShape: oblongImprint: S 226

This medicine is a white, oblong, tablet imprinted with “H” and “115”.

methocarbamol 500 mg tablet

Color: whiteShape: roundImprint: West-ward 290

This medicine is a white, oblong, tablet imprinted with “H” and “115”.

methocarbamol 500 mg tablet

Color: light orangeShape: roundImprint: B134

This medicine is a white, oblong, tablet imprinted with “H” and “115”.

methocarbamol 750 mg tablet

Color: whiteShape: oblongImprint: 612 logo

This medicine is a white, oblong, tablet imprinted with “H” and “115”.

methocarbamol 500 mg tablet

Color: light orangeShape: roundImprint: G 500

This medicine is a white, oblong, tablet imprinted with “H” and “115”.

methocarbamol 500 mg tablet

Color: whiteShape: roundImprint: 611 and logo

This medicine is a white, oblong, tablet imprinted with “H” and “115”.

methocarbamol 750 mg tablet

Color: whiteShape: oblongImprint: ASC 750

This medicine is a white, oblong, tablet imprinted with “H” and “115”.

methocarbamol 500 mg tablet

Color: whiteShape: roundImprint: ASC 500

This medicine is a white, oblong, tablet imprinted with “H” and “115”.

methocarbamol 500 mg tablet

Color: orangeShape: roundImprint: AP212

This medicine is a white, oblong, tablet imprinted with “H” and “115”.

methocarbamol 750 mg tablet

Color: yellowShape: oblongImprint: AP211

This medicine is a white, oblong, tablet imprinted with “H” and “115”.

methocarbamol 750 mg tablet

Color: light orangeShape: oblongImprint: G 750

This medicine is a white, oblong, tablet imprinted with “H” and “115”.

methocarbamol 500 mg tablet

Color: whiteShape: oblongImprint: H 114

This medicine is a white, oblong, tablet imprinted with “H” and “115”.

methocarbamol 750 mg tablet

Color: whiteShape: oblongImprint: West-ward 292

This medicine is a white, oblong, tablet imprinted with “H” and “115”.

methocarbamol 750 mg tablet

Color: whiteShape: oblongImprint: logo 612

This medicine is a white, oblong, tablet imprinted with “H” and “115”.

methocarbamol 500 mg tablet

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This medicine is a white, oblong, tablet imprinted with “H” and “115”.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Methocarbamol Dosage Guide + Max Dose, Adjustments

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Medically reviewed by Drugs.com. Last updated on Mar 6, 2023.

Applies to the following strengths: 500 mg; 750 mg; 100 mg/mL

Usual Adult Dose for:

  • Muscle Spasm
  • Tetanus

Usual Pediatric Dose for:

  • Tetanus
Additional dosage information:
  • Renal Dose Adjustments
  • Liver Dose Adjustments
  • Precautions
  • Dialysis
  • Other Comments

Usual Adult Dose for Muscle Spasm

ORAL:
Initial Dose: 1500 mg orally 4 times a day

  • Doses of 6000 mg per day are generally used for the first 48 to 72 hours
  • In severe cases, doses up to 8000 mg per day may be used

Maintenance dose:
500 mg tablets: 1000 mg orally 4 times a day
750 mg Tablets: 750 mg orally every 4 hours OR 1500 mg orally 3 times a day

PARENTERAL:

  • For the relief of moderate symptoms: 1 g IV or IM once, then switch to oral
  • For relief of severe symptoms or postoperative conditions: 1 g IV or IM every 8 hours

Maximum Dose: 3 g in 24-hours
Maximum Duration: 3 consecutive days; may repeat after a drug-free interval of 48 hours

Comments:

  • Higher doses are recommended in the first 48 to 72 hours of treatment, then doses can usually be reduced to approximately 4000 mg per day.
  • Oral tablets should be administered whenever feasible; IV/IM therapy should not be administered for more than 3 consecutive days without a drug-free interval of 48 hours.

Use: As an adjunct to rest and physical therapy for the relief of discomfort associated with acute, painful musculoskeletal conditions.

Usual Adult Dose for Tetanus

Initial dose: 1 to 2 g IV followed by an additional 1 to 2 g via IV infusion
Maximal Initial Dose: 3 g

Repeat initial IV dose every 6 hours until NG tube or oral therapy is possible

Once NG tube is in place, may crush tablets, suspend in water or saline and administer through tube

  • Total oral doses of up to 24 g may be needed based on patient response

Comments:

  • There is clinical evidence to suggest this drug may have a beneficial effect in the control of the neuromuscular manifestations of tetanus.
  • This drug should not replace the usual procedure of debridement, tetanus antitoxin, penicillin, tracheotomy, attention to fluid balance, and supportive care; if used, this drug should be added to the regimen as soon as possible.

Use: To control the neuromuscular manifestations of tetanus.

Usual Pediatric Dose for Tetanus

Initial dose: 15 mg/kg or 500 mg/m2 IV; repeat initial dose every 6 hours as needed
Maximum dose: 1.8 g/m2/day IV for 3 consecutive days

Maintenance dose: May be given by injection into tubing or by IV infusion with an appropriate quantity of fluid

Comments:

  • There is clinical evidence to suggest this drug may have a beneficial effect in the control of the neuromuscular manifestations of tetanus.
  • This drug should not replace the usual procedure of debridement, tetanus antitoxin, penicillin, tracheotomy, attention to fluid balance, and supportive care; if used, this drug should be added to the regimen as soon as possible.

Use: To control the neuromuscular manifestations of tetanus.

Renal Dose Adjustments

Oral therapy: No adjustment recommended
Injectable therapy: Not recommended in patients with renal insufficiency due to the high concentration of polyethylene glycol in the solution

Liver Dose Adjustments

Use with caution, dose adjustment may be required, especially in patients with cirrhosis; however, no specific guidelines have been suggested

Precautions

CONTRAINDICATIONS:

  • Hypersensitivity to active substance or any product excipients
  • Known or suspected renal pathology (injection; due to presence of polyethylene glycol 300 in the vehicle)

Safety and efficacy or oral therapy have not been established in patients younger than 16 years.
Safety and efficacy or injectable therapy have not been established in patients younger than 18 years, except in tetanus.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
Oral Therapy: Take orally with or without food

Injectable Therapy:

  • For IV and IM administration only; do not administer subcutaneously
  • Total daily dose should not exceed 3 g per day (3 vials) for more than 3 consecutive days except in the treatment of tetanus; see below for special directions for use in tetanus

For IV Administration:

  • May administer undiluted IV directly into vein at a maximum rate of 300 mg/minute (3 mL/minute)
  • May dilute and administer via IV infusion using normal saline or D5W; 1 g (1 vial) should be diluted in no more than 250 mL
  • Use caution to avoid vascular extravasation; this hypertonic solution may cause thrombophlebitis
  • Patient should remain recumbent during and for at least 10 to 15 minutes following injection

For IM Administration:

  • Inject no more than 500 mg (5 mL) into each gluteal region
  • Injections may be repeated at 8-hour intervals; switch to oral therapy as soon as feasible

Special Directions for Use in Tetanus:

  • Inject 1 or 2 g (10 or 20 mL) directly into tubing of inserted indwelling needle.
  • Add 1 or 2 g (10 or 20 mL) to infusion bottle to allow for a total of 3 g (3 vials) as initial dose

Storage requirements:

  • Once IV infusion is prepared: Do not refrigerate

IV compatibility: Compatible in normal saline and dextrose 5% solution

General:

  • Polyethylene glycol 300 is present in the injectable formulation; large doses of polyethylene glycol 300 are known to increase preexisting acidosis and urea retention in patients with renal impairment; while the amount present is within the limits of safety, use is contraindicated in patients with renal impairment out of an abundance of caution.

Patient advice:

  • Patients should understand that this drug may impair their mental and/or physical abilities to perform hazardous tasks such as driving, and they should be counseled appropriately.
  • Patients should understand that this drug is a CNS depressant and patients should be cautioned about concomitant use of alcohol or other CNS depressants.
  • Patients should be instructed to speak with their healthcare provider if they are pregnant, intending to become pregnant or breastfeeding.

Frequently asked questions

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Related treatment guides

  • Muscle Spasm
  • Opiate Withdrawal
  • Tetanus

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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Methocarbamol – instructions for use

Methocarbamol

Instruction:

  • Pharmacological action
  • Readings
  • Contraindications
  • Pregnancy and breastfeeding
  • Dosage and Administration
  • Side effects
  • Transport management
  • Classification

Pharmacological action

Methocarbamol is a central muscle relaxant that blocks polysynaptic reflexes of the spinal cord, reduces nerve transmission in the spinal and supraspinal polysynaptic pathways and prolongs the refractory period of muscle cells. Methocarbamol does not affect the contraction of muscle fibers, motor end plates or nerve fibers.

Indications

  • Painful muscle spasm in diseases and injuries of the musculoskeletal system;
  • complementary treatment for tetanus.

Contraindications

  • Hypersensitivity to methocarbamol.
  • Renal insufficiency (for injectable form).

Pregnancy and breastfeeding

Use in pregnancy

FDA fetal category C.

No adequate and well-controlled clinical studies have been conducted on the safety of methocarbamol during pregnancy.

The use of methocarbamol in pregnant women is not recommended, unless absolutely necessary, when the expected benefit to the mother outweighs the potential risk to the fetus.

Use during breastfeeding

Special studies on the safety of the use of methocarbamol during breastfeeding have not been conducted.

It is not known if the drug is excreted in breast milk. A risk to the infant cannot be ruled out.

It is recommended to stop breast-feeding if the drug is used.

Dosage and Administration

Children, tetanus only, IV: 15 mg/kg or 500 mg/m 2 every 6 hours, maximum dose 1.8 g/m 2 /day for 3 days.

Adults: muscle spasm – by mouth: 1.5 g 4 times a day for 2-3 days, then 4-4.5 g / day in 3-6 divided doses; intramuscularly, intravenously (if it is impossible to ingest): 1 g 3 times a day for 3 days; tetanus IV: 1–2 g bolus, then infusion, 1–2 g, maximum total dose 3 g; if necessary, this scheme is repeated every 6 hours.

Side effects

The frequency of occurrence of adverse reactions has not been determined.

From the cardiovascular system

Bradycardia, hyperemia, hypotension, syncope, thrombophlebitis.

From the side of the central nervous system

Amnesia, ataxia, confusion, dizziness, drowsiness, headache, insomnia, metallic taste, sedation, convulsions, dizziness.

Skin

Itching, skin rash, urticaria.

From the gastrointestinal tract

Dyspepsia, nausea, vomiting.

Hematological and oncological disorders

Leukopenia.

From the liver

Cholestatic jaundice, jaundice.

Hypersensitivity

Anaphylaxis, angioedema, hypersensitivity reactions.

Local

Local exfoliation of the skin (injection), pain at the injection site.

On the part of the organ of vision

Blurred vision, conjunctivitis, diplopia, nystagmus.

Respiratory

Nasal congestion.

Other

Fever.

Influence on the ability to drive vehicles and control mechanisms

Due to the fact that methocarbamol can cause dizziness and drowsiness, it is necessary to refrain from driving vehicles and engaging in activities that require increased concentration of attention and speed of psychomotor reactions.

Classification

  • ATX

    M03BA03

  • Pharmacological group

    n-anticholinergics (muscle relaxants)

  • ICD codes 10

    A35 Other forms of tetanus

    R25.3 Fasciculation

    R52.9 Pain, unspecified

  • FDA pregnancy category

    C
    (risk not excluded)

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Find out more about the active substance Methocarbamol:

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Information about the active substance Methocarbamol is intended for medical and pharmaceutical professionals, for reference purposes only. The instructions are not intended to replace professional medical advice, diagnosis or treatment. The information contained here may change over time. The most accurate information on the use of preparations containing the active substance Metocarbamol is contained in the manufacturer’s instructions attached to the package.

instructions for use, dosage, composition, analogues, side effects / Pillintrip

Page reviewed by pharmacist Fedorchenko Olga Valerievna profeno + Metocarbamol GenfarMethorelaxMetocarbamol MKRobaxacetExtra Strength Tylenol Body PainIbuflexMalival CompuestoMethocarbamol IliumMethoxacet

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Methocarbamol

Composition

Methocarbamol

Formulations

Tablet

Therapeutic indications

As a short-term adjunct to the symptomatic treatment of acute musculoskeletal disorders associated with painful muscle spasms.

Dosage and Administration

For oral use.

Dosage

Adults: The usual dose is 2 tablets four times daily, but therapeutic response has been achieved with doses as low as 1 tablet three times daily.

Elderly: Half the maximum dose or less may be sufficient to obtain a therapeutic response.

Pediatric population

Not recommended.

Liver disorders

In patients with chronic liver disease, the half-life may be increased. Therefore, consideration should be given to increasing the dose interval.

Contraindications

Coma or precoma. Known brain damage or epilepsy. Myasthenia gravis.

Special warnings and precautions

Methocarbamol 750 should be used with caution in patients with renal or hepatic impairment.

Effects on the ability to drive and use machines

This product may cause drowsiness and patients receiving it should not drive or operate machinery unless their physical and mental abilities are not affected – especially if other drugs that may cause drowsiness are also being taken.

Side effects

Adverse reactions reported concomitantly with methocarbamol include

Body as a Whole: Angioedema, anaphylactic reaction, fever, headache.

Cardiovascular system: Bradycardia, flushing, hypotension, syncope.

Digestive system: Dyspepsia, jaundice (including cholestatic jaundice), nausea and vomiting.

Blood and lymphatic system: Leukopenia.

Nervous System: Restlessness, anxiety, tremor, amnesia, confusion, diplopia, dizziness or vertigo, dizziness, drowsiness, insomnia, mild muscle incoordination, nystagmus, convulsions (including grand mal).

Skin and special sensations: Blurred vision, conjunctivitis with nasal congestion, metallic taste, itching, rash, urticaria.

Reporting suspected adverse reactions

It is important to report suspected adverse reactions after a medicinal product has been approved. This allows you to constantly monitor the balance of benefit / risk of the drug. Healthcare professionals are asked to report any suspected adverse reactions through the Yellow Card System, website: www. mhra.gov.uk/yellowcard.

Overdose

Limited information is available on the acute toxicity of methocarbamol. An overdose of methocarbamol is often combined with alcohol or other CNS depressants and includes the following symptoms: nausea, drowsiness, blurred vision, hypotension, seizures, and coma. One adult survived after deliberately ingesting 22 to 30 grams of methocarbamol without serious toxicity. Another adult survived a dose of 30 to 50 grams. The main symptom in both cases was extreme drowsiness. Treatment was symptomatic and recovery was uneventful. However, there have been cases of fatal overdose.

Treatment of overdose includes symptomatic and supportive treatment. Supportive measures include maintaining an adequate airway, monitoring urination and vital signs, and administering intravenous fluids if necessary. The usefulness of hemodialysis in the treatment of overdose is unknown.

Pharmacodynamics

Pharmacotherapeutic group: Muscle relaxants, centrally acting drugs

Methocarbamol-750 is used as a short-term adjunct to the symptomatic treatment of acute disorders of the musculoskeletal system associated with painful muscle spasms.

The mechanism of action of methocarbamol in humans has not been established, but may be due to general depression of the central nervous system. It has no direct effect on the contractile mechanism of the striated muscle, motor lamina or nerve fiber.

Pharmacokinetics

Methocarbamol is absorbed from the gastrointestinal tract and produces peak plasma concentrations in about 1-3 hours. Its activity comes from an intact molecule, and only a small part is converted to guaifenesin.

Impaired renal function

The clearance of methocarbamol in patients with impaired renal function on maintenance hemodialysis was reduced by approximately 40% compared with the normal population, although the mean half-life in the two groups was the same (1.2 and 1. 1 hour respectively).

Hepatic disorders

In patients with liver cirrhosis secondary to alcoholism, the mean total clearance of methocarbamol was reduced by approximately 70% compared with the normal population (11.