What is DM in cough syrup. How does DM cough syrup work. What are the potential side effects of DM cough syrup. When should you consult a doctor while using DM cough syrup. How to properly use DM cough syrup for optimal results.

Understanding DM Cough Syrup: Composition and Mechanism

DM in cough syrup stands for dextromethorphan, a key ingredient that acts as a cough suppressant. This compound works by decreasing the urge to cough, providing temporary relief from persistent, non-productive coughs. Dextromethorphan is particularly effective for coughs associated with certain respiratory tract infections, such as sinusitis or the common cold.

Is dextromethorphan suitable for all types of coughs? Not necessarily. While it’s effective for dry coughs, it’s generally not recommended for coughs that produce phlegm. Additionally, it’s not typically used for chronic coughs related to smoking or long-term respiratory conditions like chronic bronchitis or emphysema, unless specifically prescribed by a healthcare professional.

How DM Cough Syrup Works

Dextromethorphan operates by affecting the cough center in the brain. It suppresses the cough reflex, providing relief from persistent coughing. This mechanism is particularly beneficial for coughs that interfere with sleep or daily activities.

Proper Usage and Dosage Guidelines

Correct usage of DM cough syrup is crucial for its effectiveness and safety. The medication is typically taken orally every 4 to 12 hours as needed, or as directed by a healthcare provider. If stomach discomfort occurs, it’s advisable to take the syrup with food or milk.

• Always use a proper medication-measuring device to ensure accurate dosing.
• Avoid using household spoons, as they may not provide the correct dose.
• If using a suspension, shake the product well before measuring.

How is the dosage determined? The appropriate dose depends on several factors, including the specific product, the user’s age, medical condition, and response to treatment. For over-the-counter products, follow the dosing instructions on the packaging based on your age. If prescribed by a doctor, adhere strictly to their instructions.

Special Considerations for Children

It’s important to note that cough and cold products, including those containing dextromethorphan, have not been proven safe or effective for children under 6 years of age. Never use these products to treat cold symptoms in young children unless explicitly directed by a pediatrician.

Potential Side Effects and Precautions

While DM cough syrup is generally well-tolerated, it can cause certain side effects. Common mild side effects may include:

• Slight drowsiness or dizziness
• Nausea
• Vomiting

In rare cases, some individuals may experience severe drowsiness or dizziness even with normal doses. If any side effects persist or worsen, it’s crucial to consult a healthcare provider promptly.

Can DM cough syrup cause serious side effects? While rare, serious allergic reactions can occur. Seek immediate medical attention if you notice symptoms such as rash, itching/swelling (especially of the face, tongue, or throat), severe dizziness, or difficulty breathing.

Interactions and Precautions

Before using DM cough syrup, inform your healthcare provider about any allergies or medical conditions, particularly lung problems like asthma or emphysema. The medication may interact with alcohol or marijuana, potentially increasing drowsiness and dizziness. It’s advisable to avoid these substances while using the syrup.

Some formulations of DM cough syrup may contain aspartame. Individuals with phenylketonuria (PKU) or other conditions requiring restricted aspartame intake should consult their doctor before using these products.

When to Seek Medical Advice

While DM cough syrup can provide effective relief for many, there are instances where medical consultation is necessary. Contact your healthcare provider if:

1. Symptoms persist or worsen after a week of use
2. You develop additional symptoms like fever, chills, headache, or rash
3. The cough is accompanied by excessive phlegm or blood
4. You experience severe side effects

These symptoms may indicate a more serious underlying condition that requires professional medical attention.

Alternative Cough Relief Methods

While DM cough syrup can be effective, there are other ways to manage cough symptoms, especially for those who prefer non-medicinal approaches or cannot use dextromethorphan.

• Staying well-hydrated by drinking plenty of fluids
• Using a humidifier to add moisture to the air
• Trying saline nasal drops or sprays
• Using honey (for adults and children over 1 year old)
• Practicing good sleep hygiene

How effective are these alternative methods? While they may not provide immediate relief like medication, these approaches can help manage symptoms and support the body’s natural healing processes. They’re often recommended alongside or as alternatives to medication, especially for mild cases or for individuals who cannot use DM cough syrup.

Understanding the Limitations of Cough Suppressants

It’s crucial to understand that DM cough syrup, like other cough and cold products, does not cure or shorten the duration of the common cold. Its primary function is symptom relief. Overuse or misuse of these products can lead to serious side effects.

Why is it important to follow dosage instructions strictly? Adhering to recommended dosages helps minimize the risk of adverse effects while ensuring the medication’s effectiveness. It’s particularly crucial not to exceed recommended doses in an attempt to enhance the medication’s effects.

The Risk of Abuse

Dextromethorphan has the potential for abuse, which can result in severe consequences such as brain damage, seizures, or even death. It’s critical to use the medication only as directed and never increase the dose or frequency of use without medical supervision.

Special Considerations for Specific Groups

Certain populations need to exercise extra caution when using DM cough syrup:

Pregnant and Breastfeeding Women

If you’re pregnant or breastfeeding, consult your healthcare provider before using any cough medication, including those containing dextromethorphan. The potential risks and benefits need to be carefully evaluated.

Elderly Individuals

Older adults may be more sensitive to the effects of DM cough syrup, particularly its sedating properties. They may require dose adjustments or alternative treatments.

Individuals with Chronic Medical Conditions

People with ongoing health issues, particularly those affecting the respiratory system, should seek medical advice before using DM cough syrup. Their underlying conditions may influence the appropriateness and safety of the medication.

The Role of DM Cough Syrup in Overall Health Management

While DM cough syrup can provide effective symptom relief, it’s important to view it as part of a broader approach to health management. Coughs, especially those accompanying colds or minor respiratory infections, often resolve on their own with time and proper self-care.

How can one support overall health while managing cough symptoms? Consider these strategies:

• Maintaining a balanced diet rich in fruits and vegetables
• Getting adequate sleep and rest
• Practicing good hygiene, including regular hand washing
• Managing stress through relaxation techniques or mindfulness practices
• Staying physically active, as appropriate for your condition

These lifestyle factors can support your immune system and overall health, potentially reducing the frequency and severity of coughs and colds.

The Importance of Proper Diagnosis

While DM cough syrup can be effective for certain types of coughs, it’s not a universal solution. A persistent or severe cough may be a symptom of various underlying conditions, ranging from allergies to more serious respiratory issues. This underscores the importance of proper medical evaluation, especially for coughs that don’t respond to over-the-counter treatments or persist for extended periods.

When should you consider a cough to be abnormal or concerning? Generally, a cough that lasts more than three weeks, is accompanied by shortness of breath, chest pain, or produces blood or discolored mucus warrants medical attention. These symptoms could indicate conditions like pneumonia, bronchitis, or even more serious lung diseases that require specific treatments beyond cough suppression.

Future Developments in Cough Treatment

As medical research continues to advance, new approaches to cough treatment are being explored. These developments aim to provide more targeted and effective relief while minimizing side effects.

What potential advancements are on the horizon for cough treatment? Some areas of research include:

• Development of more selective cough suppressants that target specific cough receptors
• Exploration of natural compounds with cough-suppressing properties
• Investigation into the role of neurological pathways in cough reflex for more targeted treatments
• Research on personalized medicine approaches to cough management

While these developments are promising, it’s important to remember that current treatments, including DM cough syrup when used appropriately, remain effective options for many individuals dealing with cough symptoms.

The Role of Patient Education

Understanding the proper use, benefits, and limitations of medications like DM cough syrup is crucial for effective symptom management. Patient education plays a vital role in ensuring safe and appropriate use of these medications.

How can patients become more informed about their cough medications? Consider these steps:

1. Read medication labels carefully
2. Ask your pharmacist or healthcare provider questions about proper usage
3. Stay informed about updates or warnings related to cough medications
4. Keep a record of your symptoms and how they respond to treatment
5. Be aware of potential interactions with other medications or substances

By staying informed and maintaining open communication with healthcare providers, patients can make more informed decisions about their cough management strategies, including the use of DM cough syrup.

DM Cough Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

This medication is used for temporary relief of coughs without phlegm that are caused by certain infections of the air passages (such as sinusitis, common cold). This product should not usually be used for an ongoing cough from smoking or long-term breathing problems (such as chronic bronchitis, emphysema) unless directed by your doctor. This product contains dextromethorphan. It is a cough suppressant that works by decreasing the feeling of needing to cough.Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. Ask your doctor or pharmacist for more details about using your product safely.These products do not cure or shorten the length of the common cold and may cause serious side effects. To decrease the risk for serious side effects, carefully follow all dosage directions. Do not use this product to make a child sleepy. Do not give other cough-and-cold medication that might contain the same or similar ingredients (see also Drug Interactions section). Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms (such as drinking enough fluids, using a humidifier or saline nose drops/spray).

How to use DM Cough Syrup

Take this medication by mouth, usually every 4 to 12 hours as needed or as directed by your doctor. If stomach upset occurs, take with food or milk. Use a medication-measuring device to measure your dose of liquid medication. Do not use a household spoon because you may not get the correct dose. If you are taking a suspension, shake the product well before measuring out your dose.

Dosage is based on the product you are taking and your age, medical condition, and response to treatment. If you are using this medication for self-treatment (without a prescription from your doctor), follow the specific dosing instructions on the packaging to find the correct dose for your age.

If your doctor directs you to take this medication daily, take it regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.

Improper use of this medication (abuse) may result in serious harm (such as brain damage, seizure, death). Do not increase your dose, take it more often, or use it for a longer time than prescribed. Properly stop the medication when so directed.

Tell your doctor if your symptoms last or get worse after more than 1 week or if you also have fever, chills, headache, or rash. These may be signs of a more serious condition.

Side Effects

Slight drowsiness/dizziness, nausea, or vomiting may occur. Rarely, some people may experience severe drowsiness/dizziness with normal doses. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US –

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking dextromethorphan, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: lung problems (such as asthma, emphysema).

This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

This medicine may contain aspartame. If you have phenylketonuria (PKU) or any other condition that requires you to restrict your intake of aspartame (or phenylalanine), consult your doctor or pharmacist about using this drug safely.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Taking certain MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking isocarboxazid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, or tranylcypromine during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Ask your doctor when to start or stop taking this medication.

Some products that may interact with this drug are: other medications for cough (such as hydrocodone, over-the-counter cough/cold products), rolapitant.

Does DM Cough Syrup interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: fast heartbeat, vomiting, sweating, nervousness, feeling high (euphoria), hallucinations, problems walking (staggering), agitation, severe drowsiness.

Keep all medical and lab appointments.

If you are taking this product on a regular schedule and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

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Drug Survey

Have you ever purchased DM Cough Syrup?

Yes, In the past 3 months

Yes, In the past 6 months

Yes, In the past year

Haven’t purchased but considering

Don’t plan to purchase

This survey is being conducted by the WebMD marketing sciences department.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Cough Syrup DM Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

This combination medication is used to relieve coughs caused by the common cold, bronchitis, and other breathing illnesses. Guaifenesin belongs to a class of drugs known as expectorants. It works by thinning and loosening mucus in the airways, clearing congestion, and making breathing easier. Dextromethorphan belongs to a class of drugs known as cough suppressants. It acts on a part of the brain (cough center) to reduce the urge to cough.If you are self-treating with this medication, it is important to read the package instructions carefully before you start using this product to be sure it is right for you. (See also Precautions section.)Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. Some products (such as long-acting tablets/capsules) are not recommended for use in children younger than 12 years. Ask your doctor or pharmacist for more details about using your product safely.These products do not cure or shorten the length of the common cold and may cause serious side effects. To decrease the risk for serious side effects, carefully follow all dosage directions. Do not use this product to make a child sleepy. Do not give other cough-and-cold medication that might contain the same or similar ingredients (see also Drug Interactions section). Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms (such as drinking enough fluids, using a humidifier or saline nose drops/spray).

How to use EXTRA ACTION Cough

Take this medication by mouth with or without food, as directed by your doctor. If you are self-treating, follow all directions on the product package. If you have any questions, ask your doctor or pharmacist.

Drink plenty of fluids while taking this medication. Fluids will help to break up mucus and clear congestion.

Dosage is based on your age, medical condition, and response to treatment. Do not increase your dose or take this drug more often than directed.

If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

For powder packets, empty the entire contents of the packet onto the tongue and swallow. To prevent a bitter taste, do not chew. If you are taking the capsule form, swallow the capsule whole.

Improper use of this medication (abuse) may result in serious harm (such as brain damage, seizure, death). Do not increase your dose, take it more often, or use it for a longer time than directed.

Tell your doctor if your cough returns, or if it is accompanied by a headache that doesn’t go away, fever, severe sore throat, rash, or if it lasts or gets worse after 7 days. These may be signs of a serious medical problem. Get medical help right away if you think you may have a serious medical problem.

Side Effects

Dizziness, drowsiness, nausea, and vomiting may occur. If any of these effects last or get worse, notify your doctor or pharmacist promptly.

If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US –

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking this drug, tell your doctor or pharmacist if you are allergic to guaifenesin or dextromethorphan; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (such as emphysema, chronic bronchitis, asthma, smoker’s cough), cough with blood or large amounts of mucus, liver problems.

This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Liquid forms of this product may contain sugar and/or alcohol. Caution is advised if you have diabetes, liver disease, or any other condition that requires you to limit/avoid these substances in your diet. Ask your doctor or pharmacist about using this product safely.

The liquid forms and powder packets of this medication may contain aspartame. If you have phenylketonuria (PKU) or any other condition that requires you to restrict your intake of aspartame (or phenylalanine), consult your doctor or pharmacist about using this medication safely.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if guaifenesin or dextromethorphan passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Taking certain MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking isocarboxazid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, or tranylcypromine during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Ask your doctor when to start or stop taking this medication.

A product that may interact with this drug is: rolapitant.

Guaifenesin and dextromethorphan are available in both prescription and nonprescription products. Check the labels of all your medications to make sure you are not taking more than one product containing guaifenesin or dextromethorphan.

Guaifenesin can affect the results of certain lab tests (such as urine levels of certain acids). Make sure laboratory personnel and all your doctors know you use this drug.

Does EXTRA ACTION Cough interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: extreme drowsiness, blurred vision, confusion, hallucinations, slow/shallow breathing, seizures.

If your doctor prescribed this medication, do not share this medication with others.

Keep all medical and lab appointments.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Do not freeze liquid forms of this medication. Different brands of this medication have different storage needs. Check the product package for instructions on how to store your brand, or ask your pharmacist. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

Cough Syrup DM 10 mg-100 mg/5 mL

Color: redShape: Imprint:

This medicine is a red, clear, cherry, syrup

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Save up to 80% on your prescriptions.

Available coupons

Save up to 80% on your prescription with WebMDRx

Drug Survey

Have you ever purchased EXTRA ACTION Cough?

Yes, In the past 3 months

Yes, In the past 6 months

Yes, In the past year

Haven’t purchased but considering

Don’t plan to purchase

This survey is being conducted by the WebMD marketing sciences department.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Gedelix® cough syrup for adults and children – an effective expectorant

What is your stress level?

1. Do minor annoyances irritate you a lot?

Yes, I lose my temper easily

Lately I have more temper tantrums than usual

Occasionally

No, the little things are not worth it

What is your stress level?

2. Does waiting make you feel out of place?

Yes, I hate wasting time

I try to avoid long waits

No, but time can often be spent more efficiently0003

What is your stress level?

3. Do you blush when you are embarrassed?

Yes, I can’t control it

It happens often, but not always

I occasionally blush, but rather not

I have complete control over all my reactions

What is your stress level?

4. Can you insult someone when you are angry?

Yes, I am very quick-tempered

If he is very annoying, I can

This happens very rarely, I struggle with my irritability

No, never

What is your stress level?

5. Are you annoyed by criticism?

Yes, they criticize not to help

If the criticism is not well founded, then yes

Unless the criticism is completely far-fetched

No, I always take comments into account

What is your stress level?

6. If someone bumps you in the street, will you scold or push a careless passer-by in response?

Of course, next time I will be more careful

If I am in a bad mood, then yes

Only if it is intentional or very strong

No, I avoid conflicts

What is your stress level?

7. Are you busy all day long and don’t find time to rest?

Yes, I work all the time

There are often busy periods, but not always

Such labor marathons are rare for me

No, I always devote enough time to rest and entertainment

What is your stress level?

8. Do you often arrive later than necessary?

I am constantly late, I can’t do anything about it

I try to avoid such situations, but I am regularly late

Unless I delay something important

I am never late, accuracy is the courtesy of kings

What is your stress level?

9. When someone tells you something, do you interrupt your interlocutor?

Yes, it is important for me to correct a mistake or insert my opinion

Keeping up appearances but often fails

Very rarely, only if it’s important

No, it’s easier to wait your turn to speak

What is your stress level?

16. Do you have neck or back pain?

Constantly, I probably sit a lot and move little

Sometimes when I’m at the computer all day

No, it happens very rarely

Never noticed any problems

What is your stress level?

19. Does it seem to you that your merits and merits are not judged according to their merits?

I plow like an ox, of course I deserve more

Often my work seems to be overlooked, it’s frustrating

Probably not, but there were a couple of times when I didn’t get mine

No, I get everything I deserve

What is your stress level?

18. Do you want your work to be noticed more and appreciated more?

Yes, I think about it a lot

Everyone wants it to some extent

It would be nice, but in general I don’t care

My work is already highly appreciated

What is your stress level?

17. Do you find yourself tapping your fingers on the table?

I am often told about this

If I am very nervous, then yes

Very rarely, rather not

This does not happen

What is your stress level?

11. Are you worried for no good reason?

Yes, it seems to me that there is a problem everywhere

Often I could be calmer

No, I am very rarely driven

Why, if there are no reasons?

What is your stress level?

15. Do you feel like something is wrong with your heart?

Yes, I am being treated

It often seems so, but everything passes quickly

Sometimes there are pains, but if it were serious, I would already go to the doctor

No, I’m fine

What is your stress level?

14. You don’t get enough sleep, do you get up tired?

Yes, no matter how much I sleep

Often an extra hour of sleep does not hurt

Only if I sleep very little

No, I always get enough sleep

What is your stress level?

13. Do you feel tired all the time and can’t rest?

Yes, nothing seems to help anymore

I work a lot and get tired often

Only when I really need to work

No, I always have a good rest

What is your stress level?

12. Do you feel sick in the morning, dizzy?

Yes, I can’t even have breakfast

This happens, most often due to lack of sleep

It happened a couple of times in the last month

No, I wake up alert and full of energy

What is your stress level?

10. Will you lose your appetite?

I don’t want to eat all the time and skip meals

I have problems with appetite, but I try to stick to the regimen

I have a good appetite and it rarely changes

The sky will fall to earth rather than I will miss lunch!

What is your stress level?

20. Do you want to lose weight or gain muscle mass?

Yes, I do it actively

I would like to, but I don’t have time for that right now

Sometimes I think about it, but I don’t

No, everything suits me

Panatus Forte syrup 7.5mg (5ml) for dry cough

MINISTRY OF HEALTH OF THE RUSSIAN FEDERATION

INSTRUCTION
FOR THE USE OF MEDICINE FOR MEDICAL USE 90 003

Registration number:

Trade name: Panatus ^® forte

International non-proprietary or group name: butamirate

Dosage form: syrup

Composition

per 5 ml syrup

Active ingredient: butamirate citrate 7. 50 mg

Excipients : citric acid, monohydrate, sorbitol, liquid, glycerol, sodium saccharinate, sodium benzoate, lemon flavor, sodium hydroxide, purified water

Description

Colorless to slightly yellowish clear liquid with a characteristic odor.

Pharmacotherapeutic group: antitussive agent of central action

ATC code: R05DB13

9 0691

Pharmacological properties

Butamirate citrate is a non-opioid cough suppressant. Does not form dependence or addiction.

Pharmacodynamics

Butamirate is a centrally acting antitussive. However, the exact mechanism of action of the drug is unknown. Butamirate citrate has nonspecific anticholinergic and bronchospasmolytic effects. Suppresses cough, having a direct effect on the cough center. It has a bronchodilating effect (expands the bronchi). Helps facilitate breathing by improving spirometry (reduces airway resistance) and blood oxygenation (oxygenates the blood). In therapeutic doses, the drug is well tolerated. Butamirate in syrup dosage form has a soothing effect on an irritated throat due to the moisturizing properties of glycerol.

Pharmacokinetics

Absorption

Butamirate is rapidly and completely absorbed when taken orally and hydrolyzed to 2-phenylbutyric acid and diethylaminoethoxyethanol. The effect of simultaneous food intake on the processes has not been studied. The content of 2-phenylbutyric acid and diethylaminoethoxyethanol in blood plasma is proportional in the dose range of 22.5-90 mg.

Measurable concentrations of butamirate are detectable in blood 5-10 minutes after doses of 22.5 mg, 45 mg, 67.5 mg and 90 mg. The maximum concentration (C _max ) in plasma is reached 1 hour after taking all 4 doses, and the average C _max in plasma is 16. 1 ng / ml when taking a dose of 90 mg.

Average C _max 2-phenylbutyric acid is reached within 1.5 hours, and the maximum exposure is observed after application of 90 mg (3052 ng / ml). The average C _max diethylaminoethoxyethanol is reached after 0.67 hours, the maximum exposure is also noted after taking 90 mg (160 ng/mL).

Distribution

Butamirate has a volume of distribution between 81 l and 112 l (given body weight in kg), as well as a high degree of binding to plasma proteins. 2-phenylbutyric acid has a high degree of binding to blood plasma proteins in the dose range of 22.5-90 mg, with an average value of 89.3-91.6%. Diethylaminoethoxyethanol binds to some extent to plasma proteins, the average values ​​vary from 28.8% to 45.7%.

There are no data on the penetration of butamirate through the placental barrier and its excretion in breast milk.

Metabolism

Hydrolysis of butamirate occurs rapidly, metabolite concentrations are detected after 5 minutes. Based on these studies, it is believed that these metabolites also have antitussive activity, but there are no clinical data on the metabolism of diethylaminoethoxyethanol. 2-phenylbutyric acid undergoes further partial metabolism by hydroxylation at the para position.

Excretion

24 hours after ingestion, the main metabolites (77%) consist of conjugated 2-phenylbutyric acid and parahydroxy-2-phenylbutyric acid. Excretion of 2-phenylbutyric acid, diethylaminoethoxyethanol and parahydroxy-2-phenylbutyric acid is carried out mainly by the kidneys.

The level of 2-phenylbutyric acid conjugate in urine significantly exceeds its level in blood plasma. Butamirate is determined in the urine within 48 hours after oral administration. The amount of butamirate excreted in the urine within 96 hours corresponds to 0.02%, 0.02%, 0.03% and 0.03% at drug doses of 22.5 mg, 45 mg, 67.5 mg and 90 mg. Butamirate metabolites are excreted in larger quantities. The half-life (T _½ ) of butamirate is 1. 48-1.93 hours, 2-phenylacetic acid is 23.26-24.42 hours, diethylaminoethoxyethanol is 2.72-2.90 hours.

Special groups of patients

There are no data on changes in the pharmacokinetics of the drug in patients with impaired liver or kidney function.

Indications for use

Symptomatic treatment of dry cough of various etiologies.

Contraindications

Hypersensitivity to the components of the drug, pregnancy (I trimester), breastfeeding, children under 3 years of age, simultaneous use with expectorant drugs, fructose intolerance.

With caution

Pregnancy (II-III trimesters).

Use during pregnancy and lactation

There are no data on the safety of Panatus ^® forte during pregnancy and its passage through the placental barrier. Panatus ^® forte is contraindicated in the first trimester of pregnancy. In the II and III trimesters of pregnancy, it can be used only after consulting a doctor. Given the lack of data on the release of butamirate into breast milk, the use of Panatus ^® forte is contraindicated during breastfeeding.

Dosage and administration

Inside, before meals.

Children 3 to 6 years: 5 ml 3 times a day; children 6 to 12 years old: 10 ml 3 times a day; children over 12 years old: 15 ml 3 times a day; adults: 15 ml 4 times a day.

Use the measuring spoon (supplied). 1 measuring spoon = 5 ml.

If the cough persists for more than 5-7 days, you should consult a doctor.

Side effects

The adverse reactions presented below are listed according to the damage to organs and systems, as well as the frequency of occurrence. World Health Organization (WHO) side effect classification:

very common ≥ 1/10

often ≥ 1/100 to < 1/10

Uncommon ≥ 1/1000 to < 1/100

Rare ≥ 1/10000 to < 1/1000

Very rare < 1/10000 , including individual messages.

Nervous system disorders:

rarely – drowsiness.

Gastrointestinal disorders:

rarely – nausea, diarrhea.

Skin and subcutaneous tissue disorders:

rarely – urticaria, allergic reactions may develop.

Overdose

Symptoms: drowsiness, nausea, vomiting, diarrhea, dizziness, low blood pressure.

Treatment: no specific antidote available. In case of an overdose, gastric lavage should be done, activated charcoal should be taken and vital functions of the body should be maintained.

Interaction with other drugs

No drug interactions have been reported for butamirate.

Due to the fact that butamirate suppresses the cough reflex, the simultaneous use of expectorants is contraindicated in order to avoid the accumulation of sputum in the respiratory tract with the risk of developing bronchospasm and respiratory tract infection.

During the period of use of Panatus ^® forte, the use of ethanol, as well as drugs that depress the central nervous system (hypnotics, antipsychotics, tranquilizers, etc.) is not recommended.

Special instructions

If after 5-7 days of using Panatus ^® forte the cough does not stop, you should consult a doctor.

Information on excipients

Panatus ^® forte contains sodium saccharinate and sorbitol as sweeteners, so it can be used in patients with diabetes mellitus.

5 ml syrup (1 scoop) contains 1.75 g sorbitol. With each single dose of the drug, the patient receives either 1.75 g of sorbitol (1 scoop), or 3. 5 g of sorbitol (2 scoops), 5.25 g of sorbitol (3 scoops).

Sorbitol may cause gastrointestinal discomfort and may have a mild laxative effect .

Panatus ^® forte is contraindicated in patients with fructose intolerance.

1 dose of Panatus ^® forte contains less than 1 mmol of sodium (23 mg), i.e. essentially a “sodium-free” preparation.

Influence on the ability to drive vehicles, mechanisms

Panatus ^® forte may cause drowsiness, so care must be taken when driving vehicles and mechanisms that require increased concentration and psychomotor speed.

Formulation

Syrup, 7.5 mg/5 ml.

200 ml syrup in a dark glass bottle sealed with a plastic stopper with a liquid divider and a plastic cap with a first opening control.

1 bottle, together with instructions for use and a measuring spoon, is placed in a cardboard box.