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What is the drug methylprednisolone used for: Methylprednisolone: MedlinePlus Drug Information

Methylprednisolone Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

Methylprednisolone is used to treat conditions such as arthritis, blood disorders, severe allergic reactions, certain cancers, eye conditions, skin/kidney/intestinal/lung diseases, and immune system disorders. It decreases your immune system’s response to various diseases to reduce symptoms such as swelling, pain, and allergic-type reactions. This medication is a corticosteroid hormone.Methylprednisolone may also be used with other medications in hormone disorders.

How to use Methylprednisolone

Take this medication by mouth as directed by your doctor, usually with food or milk. Follow your dosing instructions carefully. The dosage and length of treatment are based on your medical condition and response to treatment. Different dosing schedules exist for this medication. If you are not taking the same dose each day or if you take this medication every other day, it may help to mark your calendar with a reminder. Consult your doctor or pharmacist if you have any questions.

Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.

Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Your dose may need to be gradually decreased.

If you suddenly stop using this medication, you may have withdrawal symptoms (such as weakness, weight loss, nausea, muscle pain, headache, tiredness, dizziness). To help prevent withdrawal, your doctor may lower your dose slowly. Withdrawal is more likely if you have used methylprednisolone for a long time or in high doses. Tell your doctor or pharmacist right away if you have withdrawal. See also Precautions section.

Tell your doctor if your condition does not improve or if it worsens.

Side Effects

Nausea, vomiting, heartburn, headache, dizziness, trouble sleeping, appetite changes, increased sweating, or acne may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may make your blood sugar rise, which can cause or worsen diabetes. Tell your doctor right away if you have symptoms of high blood sugar such as increased thirst/urination. If you already have diabetes, check your blood sugar regularly as directed and share the results with your doctor. Your doctor may need to adjust your diabetes medication, exercise program, or diet.

This medication may lower your ability to fight infections. This may make you more likely to get a serious (rarely fatal) infection or make any infection you have worse. Tell your doctor right away if you have any signs of infection (such as sore throat that doesn’t go away, fever, chills, cough, white patches in the mouth).

Tell your doctor right away if you have any serious side effects, including: unusual weight gain, menstrual period changes, bone/joint pain, easy bruising/bleeding, mental/mood changes (such as mood swings, depression, agitation), muscle weakness/pain, puffy face, slow wound healing, swelling of the ankles/feet/hands, thinning skin, unusual hair/skin growth, vision problems, fast/slow/irregular heartbeat, symptoms of stomach/intestinal bleeding (such as stomach/abdominal pain, black/tarry stools, vomit that looks like coffee grounds).

Get medical help right away if you have any very serious side effects, including: seizures.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking methylprednisolone, tell your doctor or pharmacist if you are allergic to it; or to prednisone; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: bleeding problems, blood clots, brittle bones (osteoporosis), diabetes, eye diseases (such as cataracts, glaucoma, herpes infection of the eye), heart problems (such as recent heart attack, congestive heart failure), high blood pressure, current/past infections (such as those caused by tuberculosis, threadworm, herpes, fungus), kidney disease, liver disease, mental/mood conditions (such as psychosis, depression, anxiety), stomach/intestinal problems (such as diverticulitis, ulcer, ulcerative colitis), seizures.

This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Talk to your doctor if you are using marijuana (cannabis).

This medicine may cause stomach bleeding. Daily use of alcohol while using this medicine may increase your risk for stomach bleeding. Limit alcoholic beverages. Consult your doctor or pharmacist for more information.

Methylprednisolone can make you more likely to get infections or may make current infections worse. Stay away from anyone who has an infection that may easily spread (such as chickenpox, COVID-19, measles, flu). Talk to your doctor if you have been exposed to an infection or for more details.

Tell your health care professional that you are using methylprednisolone before having any immunizations, vaccinations, or skin tests. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Using corticosteroid medications for a long time can make it more difficult for your body to respond to physical stress. Before having surgery or emergency treatment, or if you get a serious illness/injury, tell your doctor or dentist that you are using this medication or have used this medication within the past 12 months. Tell your doctor right away if you develop unusual/extreme tiredness or weight loss. If you will be using this medication for a long time, carry a warning card or medical ID bracelet that identifies your use of this medication. See also Medical Alert section.

Older adults may be more sensitive to the side effects of this drug, especially bone loss/pain, stomach/intestinal bleeding, and mental/mood changes (such as confusion).

This medication may slow down a child’s growth if used for a long time. Consult the doctor or pharmacist for more details. See the doctor regularly so your child’s height and growth can be checked.

During pregnancy, this medication should be used only when clearly needed. It may rarely harm an unborn baby. Discuss the risks and benefits with your doctor. Infants born to mothers who have been using this medication for a long time may have hormone problems. Tell your doctor right away if you notice symptoms such as nausea/vomiting that doesn’t stop, severe diarrhea, or weakness in your newborn.

This medication passes into breast milk, but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug include: aldesleukin, mifepristone, other drugs that can also cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, “blood thinners” such as warfarin/dabigatran, NSAIDs such as ibuprofen, celecoxib, aspirin, salicylates).

If your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually 81-162 milligrams a day), you should continue taking it unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.

Other medications can affect the removal of methylprednisolone from your body, which may affect how methylprednisolone works. Examples include azole antifungals (such as ketoconazole), cyclosporine, estrogens, HIV protease inhibitors (such as darunavir), macrolide antibiotics (such as erythromycin), ritonavir, St. John’s wort, some drugs used to treat seizures (such as phenytoin, phenobarbital), among others.

This medication may interfere with certain laboratory tests (such as skin tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Does Methylprednisolone interact with other drugs you are taking?

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Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Do not share this medication with others.

If this medication is used for a long time, lab and/or medical tests (such as blood sugar/mineral levels, blood pressure, eye exams, bone density tests, height/weight measurements) should be done while you are taking this medication. Keep all medical and lab appointments. Consult your doctor for more details.

Taking this medication for a long time may cause brittle bones (osteoporosis). Lifestyle changes that help promote healthy bones include increasing weight-bearing exercise, stopping smoking, getting enough calcium and vitamin D, and limiting alcohol. Consult your doctor for specific advice.

If you are taking this medication once daily and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

If you do not take the same dose each day or if you take this medication every other day, ask your doctor or pharmacist what you should do if you miss a dose.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

methylprednisolone 4 mg tablets in a dose pack

Color: whiteShape: ovalImprint: GG 957

This medicine is a white, oval, double-scored, tablet imprinted with “GG 957”.

methylprednisolone 4 mg tablets in a dose pack

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This medicine is a white, oval, double-scored, tablet imprinted with “GG 957”.

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This medicine is a white, oval, double-scored, tablet imprinted with “GG 957”.

methylprednisolone 4 mg tablets in a dose pack

Color: whiteShape: ovalImprint: TL 001

This medicine is a white, oval, double-scored, tablet imprinted with “GG 957”.

methylprednisolone 4 mg tablets in a dose pack

Color: whiteShape: ovalImprint: 42 16 and logo 4

This medicine is a white, oval, double-scored, tablet imprinted with “GG 957”.

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This medicine is a white, oval, double-scored, tablet imprinted with “GG 957”.

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This medicine is a white, oval, double-scored, tablet imprinted with “GG 957”.

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This medicine is a white, oval, double-scored, tablet imprinted with “GG 957”.

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This medicine is a white, oval, double-scored, tablet imprinted with “GG 957”.

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This medicine is a white, oval, double-scored, tablet imprinted with “GG 957”.

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This medicine is a white, oval, double-scored, tablet imprinted with “GG 957”.

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Color: whiteShape: ellipticalImprint: MEDROL 4

This medicine is a white, oval, double-scored, tablet imprinted with “GG 957”.

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Color: whiteShape: ellipticalImprint: MEDROL 4

This medicine is a white, oval, double-scored, tablet imprinted with “GG 957”.

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Color: whiteShape: ellipticalImprint: MEDROL 32

This medicine is a white, oval, double-scored, tablet imprinted with “GG 957”.

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Color: whiteShape: ellipticalImprint: MEDROL 16

This medicine is a white, oval, double-scored, tablet imprinted with “GG 957”.

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Color: whiteShape: ellipticalImprint: MEDROL 8

This medicine is a white, oval, double-scored, tablet imprinted with “GG 957”.

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Color: whiteShape: ovalImprint: S 5 5 5

This medicine is a white, oval, double-scored, tablet imprinted with “GG 957”.

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Color: whiteShape: ovalImprint: GG 957

This medicine is a white, oval, double-scored, tablet imprinted with “GG 957”.

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Color: whiteShape: ovalImprint: 916

This medicine is a white, oval, double-scored, tablet imprinted with “GG 957”.

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Color: whiteShape: ellipticalImprint: ING 615

This medicine is a white, oval, double-scored, tablet imprinted with “GG 957”.

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This medicine is a white, oval, double-scored, tablet imprinted with “GG 957”.

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Color: whiteShape: ovalImprint: MP

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This medicine is a white, oval, double-scored, tablet imprinted with “GG 957”.

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Drug Survey

Are you currently using Methylprednisolone?

This survey is being conducted by the WebMD marketing sciences department.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Side effects, uses, dosage, and more

  1. Methylprednisolone oral tablet is available as both a generic and brand-name drug. Brand name: Medrol.
  2. This drug also comes as an injectable suspension and injectable solution. These forms are only given by a healthcare professional.
  3. Methylprednisolone is used to reduce inflammation in many conditions. These include endocrine diseases, severe allergies, ulcerative colitis, and multiple sclerosis. It’s also used to treat rheumatic diseases, such as rheumatoid arthritis and osteoarthritis.

Methylprednisolone oral tablet is a prescription drug that’s available as the brand-name drug Medrol. It’s also available as a generic drug.

Generic drugs usually cost less than the brand-name version. In some cases, the brand-name drug and the generic version may be available in different forms and strengths.

Methylprednisolone also comes as a suspension or solution. Those forms are given to you by a healthcare professional.

Why it’s used

This drug is used to treat many conditions. It helps to control inflammation and to modify your body’s immune response. It’s used to treat certain types of:

  • endocrine disorders, such as primary or secondary adrenocortical insufficiency
  • rheumatic disorders, such as rheumatoid arthritis or psoriatic arthritis
  • collagen diseases, such as lupus or systemic dermatomyositis
  • skin diseases, such as psoriasis or Stevens-Johnson syndrome
  • severe allergies that haven’t been managed with other treatment, such as seasonal or year-round allergies or allergic reactions to medications
  • eye problems, such as swelling or ulcers (sores) in your eye
  • stomach or intestinal problems, such as ulcerative colitis or Crohn’s disease
  • respiratory problems, such as lung damage caused by beryllium poisoning or by Loeffler’s syndrome that’s not managed by other treatments
  • blood disorders, such as low levels of platelets in adults, or lack of red blood cells in children
  • neoplastic diseases, such as blood cancer or cancer in the lymphatic system in adults
  • multiple sclerosis flare-ups
  • infections, such as trichinosis that affects the brain or heart

How it works

Methylprednisolone belongs to a class of drugs called glucocorticoids. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Methylprednisolone works by decreasing inflammation and changing your body’s immune response. This reduces the inflammation caused by your condition.

How long it lasts

After you take a dose of methylprednisolone, the drug may last up to 19 hours in your body.

After you stop taking methylprednisolone, the drug should be fully gone from your body within a day.

Note that instead of stopping treatment immediately, your doctor may recommend slowly decreasing your dose of methylprednisolone. This is because suddenly stopping the drug may cause withdrawal symptoms. (Withdrawal symptoms are side effects that can occur when you stop taking a drug that your body has become dependent on.)

If you have questions about how long methylprednisolone lasts in your body, ask your doctor or pharmacist.

Methylprednisolone oral tablet doesn’t cause drowsiness, but it can cause other side effects.

More common side effects

The more common side effects of methylprednisolone can include:

  • headache
  • nausea and vomiting
  • weight gain
  • confusion, excitement, and restlessness
  • swelling of your ankles, feet, or hands
  • skin problems, such as acne, thin skin, and shiny skin
  • increased thirst
  • infection
  • high blood pressure
  • muscle weakness
  • depression

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk with your doctor or pharmacist.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Allergic reactions. Symptoms may include:
    • skin rash
    • itching or hives
    • swelling of your face, lips, or tongue
  • Changes in your emotions and mood. Symptoms can include:
    • depression
    • anxiety
    • intense excitement or happiness
    • personality changes
    • psychosis
  • Eye problems. Symptoms can include:
    • changes in your vision
    • eye pain
    • bulging eyes
  • Trouble urinating or a change in how much you urinate.
  • Diabetes. Symptoms can include:
    • increased thirst
    • urinating more often than normal
  • Pain in your hips, back, ribs, shoulders, arms, or legs.
  • Infection. Symptoms can include:
    • fever
    • sore throat
    • sneezing
    • coughing
  • Swelling of your ankles, feet, or hands.
  • Wounds that won’t heal.
  • Low potassium levels in your blood. Symptoms include:
    • weakness
    • irregular heart rhythm
  • Hormone changes. Symptoms can include:
    • loss of appetite
    • lack of energy
    • nausea
    • vomiting
    • headache
    • fever
    • joint or muscle pain
    • skin irritation
    • weight loss
    • low blood pressure, which may make you feel dizzy or faint

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare professional who knows your medical history.

Methylprednisolone oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. They’ll let you know if any interact with methylprednisolone and adjust your treatment if needed. To find out how this drug might interact with something else you’re taking, talk with your doctor or pharmacist.

Vaccines you should not receive with methylprednisolone

You should not receive certain vaccines while taking methylprednisolone. If you get such vaccines when you’re taking methylprednisolone, dangerous side effects could result. These vaccines include:

  • Live vaccines, such as the nasal flu vaccine, varicella (chickenpox) vaccine, smallpox vaccine, and measles, mumps, and rubella (MMR) vaccine: Do not receive a live vaccine while taking this drug. A live vaccine is a weakened version of the germ it protects against, such as a virus. Methylprednisolone weakens your immune system. This increases your risk of getting an infection from a live vaccine.

Interactions that increase the risk of side effects from methylprednisolone

Taking methylprednisolone with certain medications raises your risk of side effects from methylprednisolone. This is because the amount of methylprednisolone in your body is increased. Examples of these drugs include:

  • Cyclosporine: Methylprednisolone can cause cyclosporine (Gengraf, Neoral) to build up in your body and vice versa. If you use these drugs together, you may experience side effects such as seizures.
  • Ketoconazole: Your doctor may adjust your dosage of methylprednisolone if you take ketoconazole. Your doctor may do this to avoid increased side effects from methylprednisolone.

Interactions that increase the risk of side effects from other drugs

Taking methylprednisolone with certain medications raises your risk of side effects from these drugs. Examples of these drugs include:

  • Aspirin: Your chance of side effects from aspirin increases when you stop taking methylprednisolone. If you have a blood clotting problem, ask your doctor if methylprednisolone is safe for you.
  • Warfarin and heparin: When used with methylprednisolone, warfarin (Jantoven) and heparin can make your blood too thin and cause dangerous bleeding. Or they might not work as well to thin your blood. Your doctor should monitor you closely if you take either of these drugs with methylprednisolone.

Interactions that can make your drugs less effective

When methylprednisolone is used with certain drugs, it may not work as well to treat your condition. This is because the amount of methylprednisolone in your body may be decreased. Examples of these drugs include:

  • Phenobarbital, phenytoin, and rifampin: Your doctor may increase your dosage of methylprednisolone if you take phenytoin (Dilantin), phenobarbital, or rifampin (Rifadin).

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare professional about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

This dosage information is for methylprednisolone oral tablet. All possible dosages and forms may not be included here. Your dosage, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

Forms and strengths

Generic: Methylprednisolone

  • Form: oral tablet
  • Strengths: 4 milligrams (mg), 8 mg, 16 mg, 32 mg

Brand: Medrol

  • Form: oral tablet
  • Strengths: 2 mg, 4 mg, 8 mg, 16 mg, 32 mg

Dosage for multiple sclerosis

Adult dosage (ages 18 to 64 years)

  • Typical starting dosage: 160 mg per day taken in one or two doses.
  • Dosage changes: After taking 160 mg per day for 1 week, your doctor will reduce your dosage to 64 mg taken every other day for 1 month.

Child dosage (ages 0 to 17 years)

Your child’s doctor will decide your child’s dosage based on the condition being treated. They should give your child the lowest effective dosage.

Older adult dosage (ages 65 years and older)

If you’re an older adult, your kidneys may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects.

Your doctor may start you on a lowered dose or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.

Dosage for all other treated conditions

Adult dosage (ages 18 to 64 years)

  • Typical starting dosage: 4 mg to 48 mg per day taken in one or more doses.
  • Dosage changes: If you respond well to the drug, your doctor may decrease your dosage slowly until you reach the lowest possible effective dosage.
  • Alternate day therapy: If you’re going to be taking methylprednisolone for a long time, your doctor may have you take it every other day. This may reduce side effects.

Child dosage (ages 0 to 17 years)

Your child’s doctor will decide your child’s dosage based on the condition being treated. They should give your child the lowest effective dosage.

Older adult dosage (ages 65 years and older)

If you’re an older adult, your kidneys may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects.

Your doctor may start you on a lowered dose or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.

As with all medications, the cost of methylprednisolone can vary. The actual price you’ll pay depends on your insurance plan, your location, and the pharmacy you use.

Before approving coverage for methylprednisolone, your insurance company may require you to get prior authorization. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. The insurance company will review the prior authorization request and decide whether the drug will be covered.

If you’re not sure whether you’ll need prior authorization for methylprednisolone, contact your insurance company.

Financial and insurance assistance

Financial assistance to help you pay for methylprednisolone may be available.

Medicine Assistance Tool and NeedyMeds are two websites offering resources that may help decrease the price you pay for methylprednisolone. They also offer tools to help you find low cost healthcare, as well as educational resources. To learn more, visit their sites.

You can also refer to the coupons on this page for possible ways to save on methylprednisolone oral tablets.

Mail-order pharmacies

Methylprednisolone may be available through a mail-order pharmacy. Using this service may help lower the drug’s cost and allow you to get your medication without leaving home.

If you don’t have insurance, you can ask your doctor or pharmacist about online pharmacy options.

Methylprednisolone oral tablet comes with several warnings.

Hormone changes warning

This drug may cause hormone changes. It can cause your body to stop making hormones on its own. If you respond well to your dosage of this drug, your doctor may slowly reduce your dosage to reduce your risk of side effects.

Weakened immune system warning

This drug can weaken your immune system. This makes it easier for you to get infections and harder for you to fight infections. While you take this drug, you should stay away from people who are sick or who have recently been sick. This includes people who have chickenpox, measles, or the flu.

Tell your doctor if you’ve had any recent infections or if you have symptoms of an infection. These include fever, chills, or body aches.

Vaccines warning

People who receive the smallpox vaccine while taking this drug have a higher risk of serious side effects. You should wait 3 months after your last dose of methylprednisolone before you receive the smallpox vaccine.

Tell your doctor that you’re taking this drug before getting any vaccines, especially live vaccines.

Allergy warning

Methylprednisolone can cause a severe allergic reaction. Symptoms can include:

  • itching
  • hives
  • trouble breathing
  • swelling of your throat or tongue

If you have an allergic reaction, call your doctor right away. You can also seek guidance from America’s Poison Centers at 800-222-1222 or through its online tool. If your symptoms are severe, call 911 or go to the nearest emergency room.

Food interactions warning

You should not eat grapefruit or drink grapefruit juice during your treatment with this drug. Doing so can increase the levels of methylprednisolone in your blood. This raises your risk of side effects.

Warnings for people with certain health conditions

For people with heart disease: This drug can increase your blood pressure. It can also cause your body to retain salt and water. Tell your doctor about your history of heart disease.

For people with diabetes: This drug may affect your body’s ability to manage your blood sugar level. You might need to test your blood sugar level more often. Tell your doctor about your history of diabetes.

For people with ulcers: This drug may cause stomach bleeding. Tell your doctor if you have an ulcer or have had an ulcer in the past.

For people with glaucoma: This drug can increase the pressure in your eyes if you take it for a long time. Tell your doctor if you have glaucoma or any other eye-related illness before you start taking this drug.

For people with infections: This drug may make it harder for your body to fight off your infection. Ask your doctor if this drug is safe for you.

For people with liver problems: If you have cirrhosis, you may not be able to process this drug as well as you might otherwise. This may increase the levels of methylprednisolone in your body and cause more side effects. Your doctor may start you on a lower dosage depending on your liver function.

For people with hypothyroidism: You have a higher risk of side effects from this drug. Tell your doctor about your history of thyroid disease. You may need a lower dosage of this drug.

For people with herpes of the eye: Ask your doctor if this drug is safe for you. You may have a higher risk of side effects.

For people with systemic sclerosis: Corticosteroids, including this drug, increase your risk of scleroderma renal crisis. Your doctor will monitor you carefully if you have systemic sclerosis and you take methylprednisolone.

Warnings for other groups

For pregnant people: There haven’t been enough studies done to be certain how methylprednisolone might affect a pregnancy. Talk with your doctor if you’re pregnant or plan to become pregnant. Methylprednisolone should only be used during pregnancy if the benefits outweigh potential risks to the pregnancy.

Contact your doctor right away if you become pregnant while taking this drug.

For people who are breastfeeding: Methylprednisolone may pass into breast milk and cause side effects in a child who is breastfed. Talk with your doctor if you breastfeed your child. They may recommend that you stop breastfeeding or suggest a different medication for your condition.

For older adults: The kidneys of older adults may not work as well as they used to. This can cause the body to process drugs more slowly. As a result, more of a drug stays in the body for a longer time. This raises the risk of side effects. If you’re an older adult, you may need a lower dosage or you may need a different dosing schedule.

For children: This drug may slow your child’s growth. Your child’s doctor should monitor your child’s height and growth regularly. Children should use the lowest effective dosage of this drug to decrease the risks of slowed growth.

Methylprednisolone oral tablet is used for long-term or short-term treatment. Your length of treatment depends on your condition and how your body responds to treatment. It comes with serious risks if you don’t take it as prescribed.

If you stop taking the drug suddenly or don’t take it at all: Your symptoms, such as inflammation and pain, may not get better. You may have more flare-ups of your disease and your disease won’t be managed.

Do not stop taking this drug without speaking to your doctor first. This drug can disrupt how your body controls hormones. Stopping it suddenly can cause side effects. If you need to stop taking this drug, your doctor will slowly lower your dosage. This will reduce your risk of side effects.

If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

If you take too much: You could have dangerous levels of the drug in your body. Signs and symptoms of an overdose of this drug can include:

  • high blood pressure
  • salt and water retention, which may cause swelling of your arms, legs, or feet
  • low potassium levels in your blood, which may cause weakness, tiredness, and muscle cramps

If you think you’ve taken too much of this drug, call your doctor right away. You can also seek guidance from America’s Poison Centers at 800-222-1222 or through its online tool. However, if your symptoms are severe, call 911 or go to the nearest emergency room right away.

What to do if you miss a dose: If you miss a dose, take it as soon as you can. If it’s almost time for your next dose, talk with your healthcare professional. You may need to miss a dose or take an extra dose. Do not take double or extra doses without talking with your healthcare professional first.

How to tell if the drug is working: The inflammation caused by your condition should decrease.

Keep these considerations in mind if your doctor prescribes methylprednisolone oral tablet for you.

General

  • Take this drug with food or milk. This may help to reduce upset stomach.
  • If you take this drug once per day, take it in the morning. You can cut or crush the tablet.

Storage

  • Store this drug at room temperature. Keep it between 68°F and 77°F (20°C and 25°C).
  • Don’t store this medication in moist or damp areas, such as bathrooms.

Refills

A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

When traveling with your medication:

  • Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t hurt your medication.
  • You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled container with you.
  • Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Clinical monitoring

During your treatment with this drug, your doctor will monitor you for signs of side effects. Your doctor may also monitor certain health issues. This can help make sure you stay safe while you take this drug. These issues include:

  • Height and weight. This drug can slow growth in children. Your child’s doctor will monitor their growth.
  • Eye pressure. This drug can cause eye problems. Your doctor may do tests to check your eye pressure.
  • Potassium levels. This drug can lower your potassium levels. Your doctor will do blood tests to check your potassium levels.
  • Blood sugar levels. This drug may raise your blood sugar levels. Your doctor will check your blood sugar during treatment.
  • Blood pressure. This drug can raise your blood pressure. Your doctor will check your blood pressure during treatment.

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk with your doctor about possible alternatives.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.

The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

Read the article in Spanish.

The use of methylprednisolone in the treatment of children with cancer

Chemotherapy
Supportive care

Trademarks:

Depo-Medrol®, Medrol®, Solu-Medrol®

Other names:

Methylprednisolone Acetate, Methylprednisolone Sodium Succinate

Often used for:

Leukemia, lymphoma, side effects of cancer treatment, graft versus host disease (GVHD) after stem cell transplant

Methylprednisolone is a corticosteroid that is also used in chemotherapy. In addition, it can be used as an anti-inflammatory agent or an immunosuppressant.

Methylprednisolone can be used to reduce the body’s natural immunity to prevent and treat GVHD during hematopoietic cell transplantation. In addition, it can be used to treat inflammation, allergies, asthma, skin rashes, pneumonia, and adrenal disorders.

During treatment, urine and blood tests may be done to monitor blood sugar, potassium, calcium, and certain hormones. With long-term use of methylprednisolone, the patient will be monitored to identify possible disturbances in the functioning of the organs of vision and changes in growth.

Oral tablets

Administered intravenously (by drip) in liquid form

Intramuscular injection in liquid form

  • Sleep disorders
  • Increased appetite
  • Character changes or mood swings
  • Anxiety
  • Stomach irritation
  • Heartburn
  • Nausea or vomiting
  • Fluid retention, swelling of the legs or feet
  • Increased risk of infection
  • Slow wound healing
  • High blood sugar
  • Increased fatigue or general weakness
  • Headache
  • Dizziness
  • Acne
  • Dry skin
  • Increased sweating
  • Visual disturbances
  • Changes in the menstrual cycle

The listed side effects are not observed in all patients who are prescribed methylprednisolone. The most common side effects are highlighted in bold, but others are not excluded. Report all possible side effects to your doctor or pharmacist.

Some patients may experience long-term side effects or long-term effects that persist from the time of taking the drug or appear only several months or years after the end of the drug. Possible side effects with long-term use of methylprednisolone: ​​

  • Muscle loss and muscle weakness
  • Growth disorders
  • Thin, fragile skin
  • Brittle bones, osteoporosis
  • Eye disorders including cataracts and glaucoma
  • Secondary cancer (Kaposi’s sarcoma)

Be sure to discuss these and other recommendations with your doctor or pharmacist.

  • Your healthcare team may recommend a diet that is low in sodium and sugar and high in protein. A nutritionist will give advice on healthy eating with increased appetite.
  • Sexually active patients should use contraceptive methods during the course of therapy.
  • Pregnant or breastfeeding patients should notify their physician.
Home use of methylprednisolone: ​​
  • Methylprednisolone should be taken at the same time each day. When used once a day, the drug must be taken in the morning.
  • The drug should be taken with food or milk to reduce stomach irritation.
  • Methylprednisolone should be stored at room temperature.
  • Take your dose as soon as possible if you miss it. Do not do this only if there is little time left until the next appointment. In no case do not double the dose at the next dose!
  • Do not use an expired drug.
  • Follow instructions for safe handling and disposal.
Additional information about methylprednisolone
  • Safe storage and disposal of medicines
  • Sex life in therapy
  • Prednisone

More about methylprednisolone

Analogs, side effects, what helps

Glucocorticosteroids are hormones that are produced in our body by the adrenal cortex. In medicine, synthetic analogues are used, which are prescribed for a lack of their own hormones, to suppress inflammation, and for allergic and immune reactions.

Glucocorticosteroids (GCS) are very “strong” drugs. Synthetic analogs of natural hormones are more anti-inflammatory than hormones in the body. This property is used to treat inflammatory diseases of the musculoskeletal system, gastrointestinal tract, connective tissue, skin, and respiratory organs. GCS is prescribed for eye diseases, allergic reactions, oncological and hematological diseases, edema and organ transplantation.

Alena Podoinitsyna, a pharmacist, talks about one of these steroid hormones, Metipred: its composition, dosage, administration and withdrawal regimen, side effects and analogues.

All products Metipred

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Metipred: composition

Metipred contains methylprednisolone, a synthetic hormone-glucocorticoid. It has immunosuppressive, anti-allergic, anti-inflammatory, anti-shock and anti-toxic effects.

The drug is produced in the form of a lyophilisate for the preparation of an injection solution and tablets.

Metipred: dosage

For therapeutic schemes, the following dosages of the drug are used:

  • Metipred tablets 4 mg and 16 mg
  • Metipred lyophilisate for solution for intravenous and intramuscular administration

The dosage and regimen of the drug depends on the disease and is prescribed by the attending physician. So, with rheumatoid arthritis, two options are possible:

  • 1 g per day intravenously for three or four days
  • 1 g per month for six months.

In emergencies, Metipred is administered intravenously. High doses of Metipred can cause cardiac arrhythmias, so this treatment is carried out only in a hospital with an ECG and a defibrillator. The injection solution is prepared using the solvent in the kit. The prepared solution can be mixed with 5% dextrose solution or 0. 9% sodium chloride solution.

The dosage of tablets may vary according to the nature of the disease and range from 4 to 48 mg per day. High doses are prescribed for multiple sclerosis (200 mg per day), cerebral edema (200-1000 mg per day) and organ transplantation (7 mg / kg per day).

For long-term use of Metipred, alternative therapy is often prescribed. It represents a special dosing regimen: twice the daily dose is taken in the morning every other day. At the same time, the maximum therapeutic effect is achieved and side reactions are reduced, such as GCS withdrawal syndrome, suppression of the own pituitary-adrenal system, Itsenko-Cushing’s syndrome and growth retardation in children.

Children in the period of growth are prescribed Metipred only according to absolute indications and under strict medical supervision. The initial dose is 0.5 mg/kg body weight per day. When choosing a dose, the doctor focuses on the severity of the condition and the patient’s response to treatment, and not on age or body weight.

Metipred: before or after meals

Metipred tablets do not indicate when to take them in relation to food. Due to the fact that the drug can cause erosive processes in the stomach and intestines, doctors recommend doing this during meals or immediately after it, with a small amount of water.

Metipred withdrawal regimen

After long-term treatment with Metipred, drug withdrawal should be gradual. This is due to the occurrence of a “withdrawal syndrome” and secondary secondary insufficiency of the adrenal cortex.

When the therapy has a positive effect, the patient is adjusted to an individual maintenance dose. To do this, the initial dose at certain intervals is gradually reduced to the minimum dose that can maintain the achieved clinical effect. At the same time, the dosing regimen of Metipred is strictly controlled for timely dose adjustment according to the circumstances. Long-term therapy should not be stopped abruptly.

Metipred side effects

Therapy with Metipred carries risks of side effects that increase with long-term use and doses greater than 6 mg per day.

During the course of treatment, the following are possible:

  • nausea, vomiting, diarrhoea, pancreatitis, steroid gastric and duodenal ulcer
  • arrhythmias, development or worsening of heart failure, hypercoagulability, thrombosis, possible spread of necrosis in patients with myocardial infarction
  • increased intracranial pressure with papilledema, convulsions, amnesia, cognitive impairment, headache, dizziness.
  • mood changes, suicidal ideation, psychotic disorders
  • cataracts, increased intraocular pressure with possible damage to the optic nerve, secondary eye infections
  • hypercalciuria, hypocalcemia, weight gain, increased protein breakdown, excessive sweating
  • peripheral edema, hypokalemia
  • growth and ossification retardation in children, osteoporosis, steroid myopathy, arthralgia, myalgia
  • delayed wound healing, tendency to develop pyoderma and candidiasis
  • allergic reactions
  • adrenal insufficiency in long-term treatment
  • Taking Metipred has special side effects for women – increased body hair and irregular menstruation.

    Metypred crosses the placental barrier. The drug is prescribed during pregnancy only according to absolute indications in the case when the benefit to the woman is higher than the risk of a negative effect on the fetus.

    There is only one contraindication for short-term use of a medicine for health reasons: hypersensitivity to methylprednisolone.

    Contraindications for use

    • systemic mycosis;
    • simultaneous use of live and attenuated vaccines with immunosuppressive doses of the drug;
    • breastfeeding period.

    Metypred analogues

    Methylprednisolone is a constituent of the following medicines:

    • Solu-Medrol
    • Medrol
    • Methylprednisolone
    • Ivepred

    Subject to the form of release and dosage, the preparations are interchangeable.

    All products Medrol

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    All products Solu-Medrol

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    Metipred or Prednisolone: ​​which is better

    Prednisolone – the active ingredient in the dosage forms of Prednisolone – has the same effect on the body as Metipred. There are dosage forms of Prednisolone on the market in the form of tablets, an injection solution, a lyophilisate for the preparation of an injection solution and an ointment for external use.

    Indications for both drugs are similar, contraindications for prednisolone are less – only hypersensitivity to the components. Prednisolone regimens are set individually. With prolonged therapy, the drug is also canceled gradually. The longer the course treatment was, the slower the maintenance dose is reduced.

    The difference between Metipred and Prednisolone is the effectiveness of the action: Metipred at a dosage of 4 mg is equivalent in effect to 5 mg of Prednisolone. And also in a larger number of dosage forms and manufacturers of the drug under the trade name Prednisolone.

    Both drugs are proven to work. Metipred or Prednisolone – the question of prescribing analogues to a particular patient is decided by the attending physician.

    Summary

    • The active ingredient of Metipred is a synthetic glucocorticosteroid hormone Methylprednisolone.