Cytotec Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Warnings:

Do not take this medication if you think that you may be pregnant. It may cause a pregnancy to end, premature birth, or birth defects. In rare cases, serious complications (such as uterine rupture) have occurred when misoprostol was used to start labor or end a pregnancy. These complications have resulted in harm to the unborn baby and mother. The risk for uterine rupture increases as your pregnancy advances and if you had prior uterine surgery (including Cesarean delivery) or if you had five or more previous pregnancies.

Avoid pregnancy while taking misoprostol and for at least one month or one completed menstrual cycle after you have stopped treatment. If you become pregnant while taking misoprostol, contact your doctor right away.

If you are pregnant, do not take this medication to reduce the risk of stomach ulcers due to aspirin or other related drugs (non-steroidal anti-inflammatory drugs-NSAIDs such as ibuprofen). Also, if you are of childbearing age, do not use this drug to reduce the risk of ulcers from NSAIDs unless you are at high risk of having an ulcer or ulcer complications.

Female patients must meet the following four requirements in order to use this drug: 1) test negative for pregnancy within two weeks before starting treatment; 2) use effective birth control to prevent pregnancy; 3) receive oral and written warnings on the dangers of using misoprostol while of childbearing age and the risks of possible birth control failure; 4) start taking misoprostol only on the second or third day of the next normal menstrual period.

This medication must not be shared with others.

Warnings:

Do not take this medication if you think that you may be pregnant. It may cause a pregnancy to end, premature birth, or birth defects. In rare cases, serious complications (such as uterine rupture) have occurred when misoprostol was used to start labor or end a pregnancy. These complications have resulted in harm to the unborn baby and mother. The risk for uterine rupture increases as your pregnancy advances and if you had prior uterine surgery (including Cesarean delivery) or if you had five or more previous pregnancies.

Avoid pregnancy while taking misoprostol and for at least one month or one completed menstrual cycle after you have stopped treatment. If you become pregnant while taking misoprostol, contact your doctor right away.

If you are pregnant, do not take this medication to reduce the risk of stomach ulcers due to aspirin or other related drugs (non-steroidal anti-inflammatory drugs-NSAIDs such as ibuprofen). Also, if you are of childbearing age, do not use this drug to reduce the risk of ulcers from NSAIDs unless you are at high risk of having an ulcer or ulcer complications.

Female patients must meet the following four requirements in order to use this drug: 1) test negative for pregnancy within two weeks before starting treatment; 2) use effective birth control to prevent pregnancy; 3) receive oral and written warnings on the dangers of using misoprostol while of childbearing age and the risks of possible birth control failure; 4) start taking misoprostol only on the second or third day of the next normal menstrual period.

This medication must not be shared with others.

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Uses

This medication is used to prevent stomach ulcers while you take NSAIDs (such as aspirin, ibuprofen, naproxen), especially if you are at risk for developing ulcers or have a history of ulcers. Misoprostol helps to decrease your risk of serious ulcer complications such as bleeding. This medication protects your stomach lining by lowering the amount of acid that comes in contact with it.This medication is also used in combination with another drug (mifepristone) to end a pregnancy.

How to use Cytotec

This medicine comes with a patient information leaflet. Read it carefully. If you have any questions about this drug, ask your doctor, nurse, or pharmacist.

Dosage is based on your medical condition and response to therapy.

If you are taking this drug to prevent stomach ulcers, take it by mouth as directed by your doctor, usually four times a day. Take it after meals and at bedtime to minimize diarrhea.

If you are taking this medication to end a pregnancy, take it by mouth exactly as directed by your doctor.

If you are using this medication to start labor, your healthcare professional will insert it into your vagina.

Avoid taking antacids that contain magnesium while using misoprostol because they may make the diarrhea it causes worse. If you need an antacid, consult your doctor or pharmacist to help you choose a product.

For ulcer prevention, continue to take this drug for as long as you take NSAIDs. Use this medication regularly in order to get the most benefit from it. Remember to use it at the same times each day.

Inform your doctor if your condition lasts or gets worse.

Side Effects

Nausea or stomach cramps may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Diarrhea is common with misoprostol and usually occurs about two weeks after you start taking it, and lasts for about a week. Be sure to keep up your intake of fluids and minerals/electrolytes to prevent dehydration. Diarrhea that doesn’t stop may sometimes lead to a large loss of your body’s water and minerals. Tell your doctor right away if you develop any of these serious signs of dehydration and mineral imbalance: dizziness, decreased urination, mental/mood changes, muscle weakness, slow/irregular heartbeat.

Tell your doctor right away if you have any serious side effects, including: menstrual problems or irregularities, unusual/heavy vaginal bleeding.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking misoprostol, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: stomach/intestinal disease (such as inflammatory bowel disease).

Daily use of alcohol and tobacco may increase your risk for stomach bleeding. Limit alcohol beverages and stop smoking. Consult your doctor or pharmacist for more information.

If you are taking this medication in combination with mifepristone to end a pregnancy, rarely the pregnancy may not end. It is very important for you to be closely monitored by your doctor and to keep your scheduled appointments to follow your progress. Be sure to have clear instructions from your doctor about who to call and what to do in case of an emergency. Expect vaginal bleeding after you take the combined medicine, however tell your doctor right away if you develop any unlikely symptoms such as severe/prolonged vaginal bleeding, signs of infection (including fever, chills), or fainting.

This drug must not be used during pregnancy to prevent stomach ulcers because of possible harm to an unborn baby (see also Warnings). If you are of childbearing age, use effective birth control methods while taking misoprostol and for at least one month or one completed menstrual cycle after you stop taking it. If you become pregnant or think you may be pregnant, inform your doctor right away.

This medication passes into breast milk. However, this drug is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.

Interactions

See also the How to Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Does Cytotec interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe drowsiness, seizures, severe dizziness, slow/irregular heartbeats.

Do not share this medication with others.

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

Store at or below 77 degrees F (25 degrees C) in a dry place away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

Cytotec 200 mcg tablet

Color: whiteShape: hexagonalImprint: SEARLE 1461 a double stomach

This medicine is a white, hexagonal, scored, tablet imprinted with “SEARLE 1461” and “a double stomach”.

Cytotec 100 mcg tablet

Color: whiteShape: roundImprint: SEARLE 1451

This medicine is a white, hexagonal, scored, tablet imprinted with “SEARLE 1461” and “a double stomach”.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Cytotec Uses, Side Effects & Warnings

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Generic name: misoprostol [ mye-so-PRAH-stole ]
Drug class: Miscellaneous GI agents

Medically reviewed by Drugs.com on Nov 30, 2022. Written by Cerner Multum.

What is Cytotec?

Cytotec is used to prevent stomach ulcers during treatment with nonsteroidal anti-inflammatory drugs (NSAID) such as aspirin, ibuprofen, naproxen, celecoxib, diclofenac, indomethacin, meloxicam, and others.

Cytotec may also be used for purposes not listed in this medication guide.

Warnings

Cytotec can cause birth defects, premature birth, uterine rupture, miscarriage, or incomplete miscarriage and dangerous uterine bleeding. Do not use this medicine if you are pregnant.

If you are able to become pregnant, you will need to have a negative pregnancy test before starting this treatment. You will also need to use effective birth control to prevent pregnancy during treatment.

Before taking this medicine

You should not use Cytotec if you are allergic to Cytotec or other prostaglandins, or if you are pregnant.

Tell your doctor if you have ever had:

May cause birth defects. Do not use if you are pregnant. You must use effective birth control while using Cytotec and for at least 1 month after your last dose. Tell your doctor if you become pregnant.

You will need to have a negative pregnancy test before starting this treatment.

Stop taking this medicine and tell your doctor right away if you become pregnant during treatment.

Ask a doctor if it is safe to breastfeed while using this medicine.

How should I take Cytotec?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Do not share this medicine with another person, even if they have the same symptoms you have.

Cytotec is usually taken four times a day with meals. The last dose of the day should be at bedtime. Follow your doctor’s instructions.

You may have nausea, stomach cramps, or diarrhea while taking this medicine, especially during the first few weeks after you start taking Cytotec. These symptoms usually last for about a week.

Call your doctor if you have severe nausea, stomach pain, or diarrhea lasting longer than 8 days.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Cytotec?

Follow your doctor’s instructions about any restrictions on food, beverages, or activity.

Cytotec side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Cytotec may cause serious side effects. Call your doctor at once if you have:

• severe ongoing stomach discomfort or diarrhea; or

• dehydration–dizziness, confusion, feeling very thirsty, less urination.

Common side effects of Cytotec may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Cytotec?

Tell your doctor about all your other medicines, especially:

• antacids.

This list is not complete. Other drugs may affect Cytotec, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

More about Cytotec (misoprostol)

• Check interactions
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• During pregnancy
• Generic availability
• Drug class: miscellaneous GI agents
• Breastfeeding
• En español

Patient resources

• Advanced Reading

Professional resources

• Prescribing Information

Related treatment guides

• Duodenal Ulcer
• NSAID-Induced Ulcer Prophylaxis
• Stomach Ulcer

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Copyright 1996-2023 Cerner Multum, Inc. Version: 10.01.

Cytotec instructions for use: indications, contraindications, side effects – description Cytotec Tablets (5334)

indications and restrictions, rules of use, alternatives

Contents

• 1 Misoprostol: indications and restrictions, rules of use, alternatives
  • 1.1 Misoprostol: uses and limits
  • 1.2 Indications
  • 1.3 Limitations and contraindications
  • 1.4 Directions for use
  • 1.5 Dosage and regimen
  • 1.6 Possible side effects
  • 1.7 Effects on the body
  • 1.8 International name and manufacturer
  • 1.9 Alternative drugs

  902 09 1.10 Mifepristone

  • 1.11 Prostaglandins
  • 1.12 Therapeutics
  • 1.13 OB/GYN applications
  • 1.14 Related videos:
  • 1.15 Q&A:
    • • 1.15.0.1 What is misoprostol and what is it used for?
      • 1.15.0.2 What are the restrictions on the use of misoprostol?
      • 1.15.0.3 How to take misoprostol correctly?
      • 1.15. 0.4 What are the alternatives to misoprostol?

Misoprostol is a drug used in gynecology for abortion and medical termination of pregnancy. The article describes the indications and restrictions for its use, as well as the rules of use and possible alternative drugs.

Misoprostol is a pharmacological agent that is actively used in medical practice. It is widely used to prevent and treat a number of diseases related to the female reproductive system. Misoprostol is a synthetic analogue of prostaglandins, hormones that regulate the functioning of the uterus and other organs of the reproductive system.

Indications for misoprostol include abortion, prevention and treatment of gastric and duodenal ulcers, induction and maintenance of labor, and control of postpartum bleeding and uterine curettage. Restrictions on the use of misoprostol include pregnancy, bleeding diathesis, anemia, chronic kidney and liver disease, hypertension, and other health problems.

In addition to misoprostol, there are alternative drugs that can be used to treat the same conditions. Some of these include methylergometrine, oxytocin, carboprost, dinoprost, and others. When prescribing alternative drugs, it is necessary to take into account the indications, the patient’s condition and possible side effects. You should always consult your doctor for advice and detailed information on the use of any drug.

Misoprostol: use and limitations

Misoprostol is a drug used in gynecology for medical termination of pregnancy and for the prevention and treatment of gastric and duodenal ulcers.

Uses

In gastroenterology, misoprostol has been used to prevent and treat gastric and duodenal ulcers associated with non-steroidal anti-inflammatory drugs (NSAIDs). It helps to reduce the secretion of gastric juice, protects the mucous membrane of the stomach and duodenum.

Restrictions

Misoprostol is not recommended for use in case of individual intolerance to the active substance or other components of the drug. It is also contraindicated in congenital anomalies of the uterus, over 10 weeks of age with medical termination of pregnancy, in pregnancy for more than 9 weeks with induction of labor. Caution should be exercised when using misoprostol in the presence of pelvic inflammatory disease and impaired renal and hepatic function.

Indications

Misoprostol is a drug that activates uterine contractions and is used for a number of medical procedures. It may be prescribed for the following indications:

1. Medical termination of pregnancy – misoprostol helps to stop the development of the embryo and causes it to exit the uterus. It is used in combination with other drugs or alone.
2. Induction of labor – medical initiation of labor is an alternative to the natural process. Misoprostol is used to stimulate uterine contractions and speed up the onset of contractions.
3. Prevention and treatment of postpartum hemorrhage – misoprostol can help contract the uterus after childbirth and prevent or reduce bleeding.
4. Treatment of gastric and duodenal ulcers – misoprostol may help protect the lining of the stomach and intestines by promoting healing and reducing acidity.

Limitations and contraindications

The drug misoprostol has certain limitations and contraindications that are important to consider before using it.

For health reasons:

• Do not use misoprostol if you are pregnant or suspected of being pregnant, as this may lead to miscarriage or fetal malformations.
• In the presence of inflammatory diseases of the gastrointestinal tract or peptic ulcer, misoprostol is also contraindicated, as it can increase the inflammatory process and cause an exacerbation of the ulcer.
• In individuals with cardiovascular disease (eg, coronary artery disease or hypertension), the use of misoprostol may be undesirable, as it may cause an increase in symptoms and exacerbation of the disease.

Age:

• The drug is not recommended for children and adolescents under 18 years of age, as its safety and efficacy in this age group have not been sufficiently studied.

Tolerability:

• Some patients may experience hypersensitivity to misoprostol or other components of the drug. In such cases, its use is contraindicated.

Before starting the use of misoprostol, always consult with your doctor to rule out contraindications and minimize the risk of possible side effects.

Instructions for use

Misoprostol is a drug that can be used in a variety of situations, depending on the medical indication. In most cases, the use of misoprostol is carried out under the supervision of a physician, who will determine the appropriate dosage and frequency of administration.

If you experience side effects, doubts or questions about the use of misoprostol, you should contact your doctor for further advice and recommendations. Remember that only a qualified medical professional can make the final decision on the use of this drug.

Dosage and regimen

The dosage and regimen of misoprostol depends on the indication for its use.

Used by mouth, under the tongue, or vaginally. For example, when terminating an early pregnancy, it is recommended to take 1 misoprostol tablet (200 mcg) under the tongue or vaginally every 3 hours for 3 days. The maximum dose is 800 mcg per day.

The following regimen is used for labor induction: misoprostol 25 mcg (1/8 tablet) vaginally or orally every 4 hours. In the absence of labor activity within 24 hours, the dose can be increased to 50 mcg (1/4 tablet), with the addition of proxolol – up to 75 mcg (3/8 tablet).

To prevent gastric ulcers when non-sleeping anti-inflammatory drugs are prescribed, the following regimen is used: misoprostol 200 mcg twice daily before meals or 30 minutes after taking the drug.

Do not exceed the recommended dosage of misoprostol as this may lead to unwanted side effects. Taking the medication should be carried out in accordance with the recommendations of the doctor and with all precautions.

Possible side effects

Misoprostol may cause some side effects, including:

• Abdominal pain and intestinal colic – these symptoms may occur after misoprostol use. They usually decrease or go away after stopping the drug;
• Diarrhea – some patients may experience frequent bowel movements and loose stools after receiving misoprostol;
• Nausea and vomiting – these symptoms may occur in some patients, especially at the beginning of the drug;
• Headache – some people may experience headache after taking misoprostol;
• Fever – some patients may experience an increase in body temperature after taking the drug;
• Flatulence – some patients may experience excess intestinal gas after misoprostol;
• Allergic reactions Rarely, misoprostol may cause an allergic reaction such as hives, itching or swelling.

If you experience any side effects after taking misoprostol, ask your doctor or pharmacist for more information and advice.

Effects on the body

Misoprostol is a drug that has a complex effect on the human body. Its main mechanism of action is to stimulate the contractile activity of the uterus, which leads to its contraction and a decrease in the volume of uterine mucous secretions.

The drug also has an effect on blood vessels, contributing to their expansion and increase in permeability. This helps to increase the flow of oxygen and nutrients to the tissues of the organs and improve their functioning.

The drug has the effect of lowering the level of the hormone progesterone, which is the reason for its use in a number of gynecological problems. Also, its use can enhance the synthesis of prostaglandins, which accordingly leads to an increase in the contractile activity of the uterus.

International name and manufacturer

Misoprostol is a synthetic drug used in medicine for a variety of purposes. It is commonly known by trade names including Misoprostol, Gastrosynthal, and Cytotec. The full international name of this drug is Misopharmaceutical group IR.

Misoprostol manufacturers are scattered throughout the world. Some well-known companies involved in the production and sale of this drug include: Pfizer (USA), Mylan (USA), Apotex (Canada), Medinova (India) and many others. These companies strictly control the quality and manufacture of misoprostol in accordance with international quality and safety standards to ensure the effectiveness and safety of its use.

Alternative drugs

Misoprostol is one of the most effective and widely used drugs for abortion induction and management of postpartum haemorrhage today. However, if there are certain restrictions on the use of this drug, doctors may recommend alternative drugs.

Another alternative drug is oxytocin. It may also be used to manage postpartum bleeding. Oxytocin is highly effective and safe, and its use usually does not cause serious side effects. This drug may be the preferred option in the absence of contraindications.

In some cases, when the use of pharmacological agents is undesirable or not available, the use of alternative methods, such as mechanical evacuation of the contents of the uterus or minimally invasive surgery, may be recommended. The doctor will choose the best treatment option depending on the specific situation and the individual characteristics of the patient.

Mifepristone

Mifepristone is a drug used to medically terminate an early pregnancy. It is an antihormonal agent that acts on progesterone receptors, blocking them and interrupting the development of the embryo.

Indications for the use of mifepristone include unwanted pregnancy up to 70 days after the last menstrual period and no contraindications for the use of this drug. An unwanted pregnancy can be caused by various factors such as unforeseen circumstances or medical reasons.

Restrictions for the use of mifepristone include superbearing conditions such as hemorrhagic disorders, acute or chronic diseases of the kidneys, liver and other organs, and prior use of certain drugs.

For the use of mifepristone, it is necessary to strictly follow the rules for its use. It should be taken on the advice of a doctor, usually taken in early pregnancy immediately after visiting a gynecologist.

Misoprostol or combined misoprostol and methotrexate are alternatives for early medical termination of pregnancy.

Prostaglandins

Prostaglandins are a group of biologically active substances that perform many important functions in the human body. These substances are derivatives of arachidonic acid and play a key role in the regulation of inflammatory and immune processes.

Prostaglandins are widely used in medicine for various purposes. They can be used in the treatment of various diseases, including inflammatory diseases, pain syndrome, urological and gynecological problems, as well as antitumor agents.

Misoprostol is one of the best known prostaglandin preparations. This drug is widely used to prevent and treat stomach and duodenal ulcers and to initiate abortion.

Prostaglandins have many side effects and limitations. They can cause headache, nausea, vomiting, diarrhea, and deterioration of kidney and liver function. Prostaglandins are also limited during pregnancy, as they can cause premature contractions and harm the fetus.

Instead of prostaglandins, there are alternative drugs that have a milder effect profile and fewer restrictions. These are, for example, proton pump inhibitors and anti-inflammatory drugs of the NSAID group. Consulting a doctor and following all directions when taking prostaglandin drugs is very important for the safety and effectiveness of treatment.

Therapeutics

Misoprostol is one of the most common and effective therapeutic agents with several indications: abortion, delivery and use in childbirth, prevention and treatment of gastrointestinal ulcers. Misoprostol is also used in obstetric practice to induce labor and stimulate labor. It acts on progesterone receptors to help contract the uterus and soften the cervix.

General rules of use: misoprostol should only be taken as prescribed by a doctor and strictly following the prescribed dosages. Usually the drug is taken intravaginally or orally, while the dosage may vary depending on the purpose of the application. When using misoprostol in obstetric practice, special care should be taken and the condition of the uterus and fetus should be monitored.

Alternative drugs: There are other drugs in addition to misoprostol that have similar properties and are used in obstetrics and gynecology. Some of them are dinoprostone and oxytocin. These remedies also stimulate uterine contractions and are effective during childbirth. However, the choice of a particular drug depends on the indications, the condition of the mother and fetus, so the decision should be left to the doctor.

Obstetrics and gynecology

Misoprostol, due to its pharmacological properties, is widely used in obstetrics and gynecology. The drug is widely used for the induction and stimulation of labor, as well as for medical termination of pregnancy.

In obstetrics, misoprostol is used to induce labor when the fetus is retarded or overterm. The drug helps to cause uterine contractions and speed up the process of childbirth, which is especially important in cases where a delay can cause complications. In addition, misoprostol can be used to prevent and treat postpartum haemorrhage, which is the leading cause of maternal death after childbirth.

In gynecology, misoprostol is used for medical abortion in early pregnancy. The drug has the ability to cause uterine contractions and rejection of the embryo. Misoprostol can be used alone to terminate a pregnancy or in combination with other drugs such as methotrexate.

However, it is important to note that the use of misoprostol in obstetrics and gynecology requires strict medical supervision and specialist supervision. Misuse of the drug or its unauthorized use can lead to serious complications and damage to health. Therefore, before starting treatment, you must consult a doctor and follow his recommendations.

Related videos:

Q&A:

What is misoprostol and what is it used for?

Misoprostol is a medicine used in gynecology and obstetrics.