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What is triamterene-hctz. Triamterene-HCTZ: A Comprehensive Guide to Uses, Side Effects, and Precautions

by alexxlab

What are the primary uses of Triamterene-HCTZ. How does this medication work to treat high blood pressure. What are the potential side effects and precautions associated with Triamterene-HCTZ. How should patients properly use this medication for optimal results.

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Understanding Triamterene-HCTZ: A Powerful Combination for Blood Pressure Management

Triamterene-HCTZ is a combination medication widely prescribed for managing high blood pressure and reducing excess fluid in the body. This potent drug consists of two diuretics: triamterene and hydrochlorothiazide. By working together, these components help regulate blood pressure and prevent potential complications associated with hypertension.

Is Triamterene-HCTZ effective for all patients with high blood pressure. While this medication is beneficial for many individuals, its efficacy can vary depending on factors such as the patient’s overall health, age, and other underlying conditions. Healthcare providers carefully assess each patient’s needs before prescribing Triamterene-HCTZ to ensure it’s the most suitable treatment option.

The Mechanism of Action: How Triamterene-HCTZ Works in Your Body

Triamterene-HCTZ operates through a dual mechanism to manage blood pressure and fluid balance. The hydrochlorothiazide component acts as a thiazide diuretic, increasing urine production and helping the body eliminate excess salt and water. This action effectively reduces blood volume, leading to lower blood pressure.

Simultaneously, triamterene serves as a potassium-sparing diuretic. It helps maintain potassium levels in the body, which is crucial since hydrochlorothiazide can cause potassium depletion. This balance is essential for proper heart and muscle function.

Key Benefits of Triamterene-HCTZ

  • Effective blood pressure reduction
  • Decreased risk of strokes and heart attacks
  • Prevention of kidney problems
  • Management of edema in various conditions
  • Maintenance of potassium balance

Can Triamterene-HCTZ help with other conditions besides hypertension. Indeed, this medication has shown efficacy in managing edema associated with heart failure, liver disease, and kidney disorders. By reducing fluid retention, it can alleviate symptoms such as shortness of breath and swelling in the ankles or feet.

Proper Administration: Maximizing the Benefits of Triamterene-HCTZ

To achieve optimal results with Triamterene-HCTZ, it’s crucial to follow the prescribed dosage and administration guidelines. Typically, healthcare providers recommend taking this medication once daily in the morning, with or without food. This timing helps prevent nighttime urination, which could disrupt sleep patterns.

Are there any specific considerations when taking Triamterene-HCTZ. Yes, patients should be aware of potential interactions with other medications. For instance, if you’re also taking cholesterol-lowering drugs like cholestyramine or colestipol, it’s advisable to space out the doses. Take Triamterene-HCTZ at least 4 hours before or 4 to 6 hours after these medications to ensure proper absorption.

Tips for Proper Use

  1. Take the medication at the same time each day
  2. Avoid taking it within 4 hours of bedtime
  3. Continue the medication even if you feel well
  4. Monitor your blood pressure regularly
  5. Report any persistent side effects to your healthcare provider

Potential Side Effects: What to Watch For When Taking Triamterene-HCTZ

While Triamterene-HCTZ is generally well-tolerated, like all medications, it can cause side effects in some individuals. Common side effects may include dizziness, lightheadedness, headache, or upset stomach, particularly as your body adjusts to the medication. These symptoms often subside over time, but it’s important to communicate any persistent or worsening effects to your healthcare provider.

Do all patients experience side effects with Triamterene-HCTZ. No, not every patient will experience side effects. The occurrence and severity of side effects can vary based on individual factors such as age, overall health, and dosage. However, it’s crucial to be aware of potential adverse reactions and report any concerning symptoms promptly.

Serious Side Effects Requiring Immediate Attention

  • Muscle weakness or cramps
  • Slow or irregular heartbeat
  • Fainting
  • Changes in vision or eye pain
  • Signs of kidney problems (changes in urination)
  • Severe allergic reactions (rash, itching, swelling, difficulty breathing)

How can patients minimize the risk of side effects. To reduce the likelihood of experiencing adverse reactions, it’s essential to follow the prescribed dosage carefully, stay well-hydrated, and maintain regular check-ups with your healthcare provider. Additionally, informing your doctor about any other medications or supplements you’re taking can help prevent potential interactions.

Precautions and Contraindications: Ensuring Safe Use of Triamterene-HCTZ

Before starting Triamterene-HCTZ, it’s crucial to provide your healthcare provider with a comprehensive medical history. Certain conditions may increase the risk of complications or require dosage adjustments. These include diabetes, gout, high potassium levels, kidney disease (including kidney stones), liver disease, lupus, and a history of skin cancer.

Are there any specific groups who should avoid Triamterene-HCTZ. Yes, this medication may not be suitable for everyone. Patients with severe kidney disease, anuria (lack of urine production), or known allergies to sulfonamide-derived drugs should generally avoid Triamterene-HCTZ. Pregnant women, especially in their second and third trimesters, should also refrain from using this medication due to potential risks to the developing fetus.

Special Considerations for Certain Populations

  • Elderly patients may be more sensitive to side effects
  • Diabetics should monitor blood sugar levels closely
  • Patients with a history of gout may experience flare-ups
  • Those with liver disease may require dosage adjustments
  • Individuals with lupus should be monitored for worsening symptoms

Drug Interactions: Navigating Potential Complications with Triamterene-HCTZ

Triamterene-HCTZ can interact with various medications, potentially altering their effectiveness or increasing the risk of side effects. It’s crucial to inform your healthcare provider about all prescription drugs, over-the-counter medications, and supplements you’re taking to avoid potentially harmful interactions.

Which medications are most likely to interact with Triamterene-HCTZ. Several classes of drugs can interact with this medication, including:

  • ACE inhibitors and ARBs (other blood pressure medications)
  • NSAIDs (non-steroidal anti-inflammatory drugs)
  • Potassium supplements
  • Certain antidepressants
  • Lithium
  • Digoxin

How can patients manage potential drug interactions. The best approach is to maintain open communication with your healthcare provider and pharmacist. They can assess the potential for interactions and make necessary adjustments to your medication regimen. In some cases, they may recommend alternative treatments or closer monitoring to ensure your safety.

Long-Term Management: Optimizing Treatment with Triamterene-HCTZ

Successfully managing high blood pressure with Triamterene-HCTZ often requires a long-term commitment. While the medication can effectively lower blood pressure, it’s not a cure for hypertension. Patients typically need to continue treatment indefinitely to maintain the benefits and prevent complications associated with high blood pressure.

What strategies can patients employ to enhance the effectiveness of Triamterene-HCTZ? Combining medication with lifestyle modifications can significantly improve outcomes. Consider incorporating the following strategies:

  1. Adopting a heart-healthy diet low in sodium and rich in fruits, vegetables, and whole grains
  2. Engaging in regular physical activity, aiming for at least 150 minutes of moderate-intensity exercise per week
  3. Maintaining a healthy weight or losing excess pounds if overweight
  4. Limiting alcohol consumption and quitting smoking
  5. Managing stress through relaxation techniques or counseling

How often should patients have their blood pressure checked while on Triamterene-HCTZ? Regular monitoring is crucial to ensure the medication is working effectively. Initially, your healthcare provider may recommend more frequent check-ups, perhaps every few weeks. Once your blood pressure stabilizes, you may transition to less frequent monitoring, typically every 3 to 6 months. However, home blood pressure monitoring can provide valuable information between office visits.

Long-Term Considerations

  • Periodic blood tests to monitor electrolyte levels and kidney function
  • Adjusting dosage as needed based on blood pressure readings and side effects
  • Addressing any new health concerns that may impact treatment
  • Discussing any plans for pregnancy, as Triamterene-HCTZ is not recommended during pregnancy

Understanding Potassium Balance: A Critical Aspect of Triamterene-HCTZ Therapy

One of the unique features of Triamterene-HCTZ is its ability to help maintain potassium balance in the body. While hydrochlorothiazide can cause potassium loss, triamterene acts as a potassium-sparing diuretic, helping to prevent excessive potassium depletion. However, this delicate balance requires careful monitoring, as both high and low potassium levels can lead to serious health complications.

Why is potassium balance so crucial for patients taking Triamterene-HCTZ? Potassium plays a vital role in various bodily functions, including heart rhythm regulation, muscle contraction, and nerve signaling. Imbalances can lead to potentially dangerous symptoms such as muscle weakness, irregular heartbeat, and in severe cases, life-threatening arrhythmias.

Monitoring Potassium Levels

  • Regular blood tests to check potassium levels
  • Watching for signs of hyperkalemia (high potassium) or hypokalemia (low potassium)
  • Adjusting diet or medication as needed based on test results
  • Being cautious with potassium supplements or salt substitutes

Can dietary choices affect potassium levels while taking Triamterene-HCTZ? Yes, diet plays a significant role in maintaining proper potassium balance. While on this medication, it’s important to be mindful of potassium-rich foods. However, complete avoidance is unnecessary and potentially harmful. Work with your healthcare provider or a registered dietitian to develop a balanced meal plan that supports your overall health while maintaining appropriate potassium levels.

Special Populations: Tailoring Triamterene-HCTZ Treatment for Specific Groups

While Triamterene-HCTZ is effective for many patients with hypertension, certain populations may require special considerations or modified approaches to treatment. Healthcare providers must carefully assess individual patient factors to ensure safe and effective use of this medication.

Elderly Patients

Older adults may be more sensitive to the effects of Triamterene-HCTZ and at higher risk for certain side effects. How should treatment be approached for elderly patients? Healthcare providers often start with lower doses and gradually increase as needed, closely monitoring for adverse reactions. Regular assessment of kidney function and electrolyte balance is crucial, as aging can affect these parameters.

Patients with Diabetes

Diabetic patients require careful management when taking Triamterene-HCTZ. Why is this medication challenging for individuals with diabetes? Triamterene-HCTZ can affect blood sugar levels and potentially increase the risk of developing new-onset diabetes. Close monitoring of blood glucose levels and potential adjustments to diabetes medications may be necessary.

Individuals with Kidney Disease

Kidney function plays a crucial role in the effectiveness and safety of Triamterene-HCTZ. How does kidney disease impact treatment with this medication? Patients with impaired kidney function may have reduced ability to eliminate the drug, potentially leading to accumulation and increased side effects. Dosage adjustments or alternative treatments may be necessary based on the severity of kidney disease.

Considerations for Special Populations

  • More frequent monitoring of blood pressure, electrolytes, and kidney function
  • Potential need for dosage adjustments or alternative medications
  • Increased vigilance for side effects and drug interactions
  • Tailored lifestyle recommendations to complement medication therapy
  • Regular reassessment of treatment goals and strategies

By carefully considering these factors and individualizing treatment plans, healthcare providers can optimize the use of Triamterene-HCTZ across diverse patient populations, ensuring the best possible outcomes while minimizing risks.

Triamterene-HCTZ Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Warnings:

This medication can raise your body’s potassium levels. The risk for this is higher for people with diabetes or kidney disease, older adults, or during severe illness. High potassium levels can cause serious (rarely fatal) side effects. Tell your doctor right away if you have any of these serious side effects: muscle weakness, slow/irregular heartbeat.

Warnings:

This medication can raise your body’s potassium levels. The risk for this is higher for people with diabetes or kidney disease, older adults, or during severe illness. High potassium levels can cause serious (rarely fatal) side effects. Tell your doctor right away if you have any of these serious side effects: muscle weakness, slow/irregular heartbeat.

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Uses

This drug is used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This medication is a combination of two “water pills” (diuretics): triamterene and hydrochlorothiazide. This combination is used by people who have developed or are at risk for having low potassium levels on hydrochlorothiazide. It causes you to make more urine, which helps your body get rid of extra salt and water.This medication also reduces extra fluid in the body (edema) caused by conditions such as heart failure, liver disease, or kidney disease. This can lessen symptoms such as shortness of breath or swelling in your ankles or feet.

How to use Triamterene-HCTZ Capsule

Take this medication by mouth with or without food as directed by your doctor, usually once daily in the morning. It is best to avoid taking this medication within 4 hours of your bedtime to prevent having to get up to urinate.

If you also take certain drugs to lower your cholesterol (bile acid-binding resins such as cholestyramine or colestipol), take this product at least 4 hours before or at least 4 to 6 hours after these medications.

The dosage is based on your medical condition and response to treatment.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Keep taking this medication even if you feel well. Most people with high blood pressure do not feel sick.

Tell your doctor if your condition does not improve or if it worsens (for example, your blood pressure readings increase).

Side Effects

See also Warning section.

Dizziness, lightheadedness, headache, or upset stomach may occur as your body adjusts to the medication. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

To lower your risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This product may cause your body to lose too much water and salt (dehydration). Tell your doctor right away if you notice any symptoms of dehydration, such as unusual dry mouth/thirst, fast heartbeat, or dizziness/lightheadedness.

Tell your doctor right away if you have any serious side effects, including: fainting, muscle cramps/weakness, slow/fast/irregular heartbeat, decrease in vision, eye pain, signs of kidney problems (such as change in the amount of urine).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking this medication, tell your doctor or pharmacist if you are allergic to triamterene or hydrochlorothiazide; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: diabetes, gout, high level of potassium in the blood, kidney disease (including kidney stones), liver disease, lupus, skin cancer.

This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Severe sweating, diarrhea, or vomiting can increase the risk for lightheadedness or dehydration. Report prolonged diarrhea or vomiting to your doctor. To prevent dehydration, drink plenty of fluids unless your doctor directs you otherwise.

If you have diabetes, this product may affect your blood sugar. Check your blood sugar regularly as directed and share the results with your doctor. Your doctor may need to adjust your diabetes medication, exercise program, or diet.

This medication may affect your potassium levels. Before using potassium supplements or salt substitutes that contain potassium, consult your doctor or pharmacist.

This medication may make you more sensitive to the sun. It may also increase your risk for skin cancer, especially if you take it for a long time. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned, have skin blisters/redness, or notice new or changed moles/skin lesions.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the effects of this drug, especially dizziness, or high blood potassium levels.

During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby. Discuss the risks and benefits with your doctor.

It is unknown if triamterene passes into breast milk. Hydrochlorothiazide passes into breast milk, but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.

Interactions

See also How to Use and Precautions sections.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug include: dofetilide, lithium, other drugs that may increase potassium levels (such as spironolactone, amiloride, cyclosporine).

Some products have ingredients that could raise your blood pressure or worsen your swelling. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen).

This medication may interfere with certain laboratory tests (including parathyroid function), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Does Triamterene-HCTZ Capsule interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe dizziness, fainting.

Do not share this medication with others.

Lifestyle changes such as stress reduction programs, exercise, and dietary changes may increase the effectiveness of this medicine. Talk to your doctor or pharmacist about lifestyle changes that might benefit you.

Lab and/or medical tests (such as kidney function, potassium levels, skin exams) should be done while you are taking this medication. Keep all medical and lab appointments. Consult your doctor for more details.

Check your blood pressure regularly while taking this medication. Learn how to monitor your own blood pressure, and share the results with your doctor.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Teva-Triamterene HCTZ – Uses, Side Effects, Interactions

How does this medication work? What will it do for me?

This combination product contains 2 medications: triamterene and hydrochlorothiazide. Both these medications belong to the class of medications called diuretics (“water pills”). They are used in combination to treat edema (fluid retention) that occurs with congestive heart failure and liver or kidney disorders. It is also used to treat mild-to-moderate high blood pressure.

This medication works by making the body lose excess water and salt. Triamterene, called a potassium-sparing diuretic, helps the body to keep potassium in, while hydrochlorothiazide causes the body to lose potassium. Therefore, potassium supplements are usually not required with this medication.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

What form(s) does this medication come in?

Each peach-coloured, round, flat-faced, bevelled-edged, compressed tablet, engraved “novo” on one side and “25/50” on the reverse, contains 50 mg of triamterene and 25 mg of hydrochlorothiazide. Nonmedicinal ingredients: colloidal silicon dioxide, FD&C Yellow No. 6 Lake, magnesium stearate, microcrystalline cellulose, sodium lauryl sulfate, and sodium starch glycolate.

How should I use this medication?

Each triamterene – hydrochlorothiazide tablet contains 50 mg of triamterene and 25 mg of hydrochlorothiazide. The usual starting dose to treat edema (fluid retention) or high blood pressure is 1 tablet twice daily after meals. The maximum daily dose is 4 tablets divided into 2 doses.

Your doctor will increase, decrease, or leave the dose the same depending on your response to the medication. If more than 1 tablet per day is needed, it should be taken in 2 divided doses. If only one dose is needed, it should be taken in the morning after breakfast.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Who should NOT take this medication?

Do not take this medication if you:

  • are allergic to hydrochlorothiazide, triamterene, or any ingredients of the medication
  • are allergic to sulfa medications (e.g., sulfamethoxazole)
  • are not producing urine or are producing very little urine
  • have increased blood potassium levels
  • have severe or progressive kidney disease
  • have severe or progressive liver disease

What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • constipation
  • decreased sexual interest or ability
  • diarrhea
  • dizziness or lightheadedness when rising from a lying or sitting position
  • dry mouth
  • enlarged glands in the mouth
  • headache
  • increased sensitivity of skin to sunlight
  • loss of appetite
  • nausea
  • pins and needles sensation in hands, feet
  • restlessness
  • stomach cramps or upset stomach
  • vomiting

Although most of these side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • discoloured patches or lumps on the skin that change slowly over time
  • signs of anemia (low red blood cells; e.g., dizziness, pale skin, unusual tiredness or weakness, shortness of breath)
  • signs of changes in potassium (e.g., confusion; drowsiness; dry mouth; increased thirst; irregular heartbeat; mood or mental changes; muscle cramps or pain; numbness or tingling in hands, feet, or lips; shortness of breath or difficulty breathing; unusual tiredness or weakness; weak pulse; weakness or heaviness of legs)
  • signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don’t stop bleeding)
  • signs of gout (e.g., hot, swollen, or painful joints)
  • signs of infection (e.g., fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness)
  • signs of kidney problems (e. g., increased urination at night, decreased urine production, blood in the urine, change of urine colour, nausea, vomiting, swelling feet, ankles, hands)
  • signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
  • symptoms of high blood sugar (e.g., frequent urination, increased thirst, excessive eating, unexplained weight loss, poor wound healing, infections, fruity breath odour)
  • vision changes

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
  • signs of pancreatitis (e.g., abdominal pain on the upper left side, back pain, nausea, fever, chills, rapid heartbeat, swollen abdomen)
  • signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Allergy: Some people who are allergic to sulfonamide antibiotics also experience allergic reactions to triamterene – hydrochlorothiazide because of the hydrochlorothiazide component. Before you take this medication, inform your doctor about any previous adverse reactions you have had to medications, especially sulfonamide (sulfa) antibiotics.

Contact your doctor at once if you experience signs of an allergic reaction such as skin rash, itching, difficulty breathing, or swelling of the face and throat.

Diabetes: People with diabetes may find that their blood sugar level is less controlled when taking triamterene – hydrochlorothiazide. If you have diabetes, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Driving and using machines: Triamterene – hydrochlorothiazide can cause dizziness or lightheadedness, which may affect your ability to perform tasks that require special attention, such as driving or operating machinery. Avoid performing any potentially hazardous tasks, including driving, until you have determined how this medication affects you.

Glaucoma: Hydrochlorothiazide may cause the symptoms of glaucoma (increased pressure in the eye) to suddenly occur. If you have glaucoma, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Report any changes in vision to your doctor as soon as possible while you are taking this medication.

Gout: This medication may cause a flare-up of gout symptoms. If you have gout or a history of gouty arthritis, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Kidney stones: Triamterene has been found in kidney stones. If you have kidney stones or a history of kidney stones, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Liver function: If you have decreased liver function or liver disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed

Potassium levels: Increased blood levels of potassium, though uncommon, are potentially the most severe side effect with this medication. This is more likely to occur if you are 60 years old or over.

Warning signs or symptoms of high potassium include numbness, muscular weakness, fatigue, paralysis of the extremities, and slow heart rate. If this condition occurs, stop taking the medication.

Potassium supplements: Potassium supplementation, either in the form of medication or as a potassium-rich diet, should not be used at the same time as triamterene – hydrochlorothiazide. Triamterene helps recycle potassium from the urine, back into the body. When it is combined with potassium supplements, high levels of potassium in the blood may result.

Low levels of potassium may also occur for some of the people taking this medication because of the potassium-lowering effect of hydrochlorothiazide.

Sensitivity to sunlight: This medication may increase the sensitivity of the skin to sunlight, increasing the risk of sunburn. Avoid exposure to sunlight for long periods of time, particularly between the hours of 10 am and 2 pm, while you are taking this medication and for 7 days after your last dose. Wear a broad-spectrum sunscreen and lip balm with an SPF of 30 or higher. If you notice any unusual skin rash or peeling, contact your doctor immediately.

Skin cancer: Recent studies of hydrochlorothiazide have connected long-term use of the medication with an increased risk of developing non-melanoma skin cancer. Check your skin regularly for unusual growths or discolouration and report any changes to your doctor as soon as possible.

Systemic lupus erythematosus: This medication can worsen or activate the symptoms of lupus. If you experience swollen and painful joints, fever, fatigue, or rash on the nose and cheeks while taking this medication, contact your doctor.

Pregnancy: Hydrochlorothiazide crosses the placenta and may affect an unborn baby. Triamterene – hydrochlorothiazide should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: Hydrochlorothiazide passes into breast milk, and triamterene may pass into breast milk. If you are a breast-feeding mother and are taking triamterene – hydrochlorothiazide, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children.

What other drugs could interact with this medication?

There may be an interaction between triamterene – hydrochlorothiazide and any of the following:

  • aclidinium
  • alcohol
  • aldesleukin
  • aliskiren
  • allopurinol
  • alpha-agonists (e.g., clonidine, methyldopa)
  • alpha-blockers (e.g., alfuzosin, doxazosin, tamsulosin)
  • amantadine
  • amifostine
  • amphetamines (e.g., dextroamphetamine, lisdexamfetamine)
  • angiotensin converting enzyme (ACE) inhibitors (e.g., ramipril, enalapril)
  • angiotensin II receptor blockers (e. g., losartan, candesartan)
  • antihistamines (e.g., cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine)
  • antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)
  • barbiturates (e.g., butalbital, pentobarbital, phenobarbital)
  • atropine
  • azelastine
  • belladonna
  • benztropine
  • beta-2 agonists (e.g., salbutamol, formoterol, terbutaline)
  • beta-adrenergic blockers (e.g., atenolol, propranolol, sotalol)
  • brimonidine
  • calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)
  • calcium supplements (e.g., calcium carbonate, calcium citrate, calcium gluconate)
  • carbamazepine
  • cholestyramine
  • colestipol
  • inhaled corticosteroids (e.g., budesonide, ciclesonide, fluticasone)
  • oral corticosteroids (e.g., dexamethasone, hydrocortisone, prednisone)
  • cyclobenzaprine
  • cyclophosphamide
  • cyclosporine
  • dexmethylphenidate
  • diabetes medications (e. g., chlorpropamide, glyburide, insulin, metformin, rosiglitazone)
  • diazoxide
  • digoxin
  • disopyramide
  • other diuretics (water pills; e.g., furosemide, hydrochlorothiazide)
  • dofetilide
  • drospirenone
  • duloxetine
  • eplerenone
  • flavoxate
  • glycopyrrolate
  • guanfacine
  • heparin
  • hydralazine
  • ipratropium
  • ivabradine
  • ketotifen
  • levodopa
  • licorice
  • lithium
  • methylphenidate
  • minoxidil
  • low molecular weight heparins (e.g., dalteparin, enoxaparin, tinzaparin)
  • multivitamin/mineral supplements
  • nitrates (e.g., nitroglycerin, isosorbide dinitrate, isosorbide mononitrate)
  • narcotic pain relievers (e.g., codeine, fentanyl, morphine, oxycodone)
  • nonsteroidal anti-inflammatory drugs (NSAIDs; e.g., diclofenac, ibuprofen, ketorolac, naproxen)
  • obinutuzumab
  • orphenadrine
  • other potassium-sparing diuretics (e. g., amiloride, spironolactone)
  • oxcarbazepine
  • oxybutynin
  • pentoxifylline
  • phosphodiesterase 5 inhibitors (e.g., sildenafil, tadalafil, vardenafil)
  • potassium supplements (e.g., potassium chloride, potassium gluconate, salt substitutes containing potassium)
  • quinidine
  • scopolamine
  • selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, fluoxetine, paroxetine, sertraline)
  • sodium phosphates
  • tacrolimus
  • tiotropium
  • tolterodine
  • tolvaptan
  • topiramate
  • tranylcypromine
  • tricyclic antidepressants (e.g., amitriptyline, clomipramine, desipramine, trimipramine)
  • umeclidinium
  • vitamin D analogues (e.g., alfacalcidol, calcitriol, cholecalciferol)
  • warfarin
  • yohimbine

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

All material copyright MediResource Inc. 1996 – 2023. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Teva-Triamterene-HCTZ

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