Xyzal Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

How to use Xyzal

If you are taking the over-the-counter product to self-treat, read and follow all directions on the product package before taking this medication. If you have any questions, consult your pharmacist. If your doctor has prescribed this medication, take it as directed.

This medication is taken by mouth with or without food, usually once daily in the evening.

If you are using the liquid form of this medication, measure the dose carefully using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

The dosage is based on your age, medical condition, and response to treatment. Do not increase your dose or take this medication more often than directed.

If your condition does not get better or if it gets worse, or if you think you may have a serious medical problem, get medical help right away.

Side Effects

Drowsiness, tiredness, and dry mouth may occur. Fever or cough may also occur, especially in children. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: difficulty urinating, weakness.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking levocetirizine, tell your doctor or pharmacist if you are allergic to it; or to cetirizine; or to hydroxyzine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: difficulty urinating (such as due to an enlarged prostate), kidney disease.

This drug may make you drowsy. Alcohol or marijuana (cannabis) can make you more drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Liquid products may contain sugar and/or aspartame. Caution is advised if you have diabetes, phenylketonuria (PKU), or any other condition that requires you to limit/avoid these substances in your diet. Ask your doctor or pharmacist about using this medication safely.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This medication passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or other antihistamines (such as diphenhydramine, promethazine).

Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

Do not use with any other antihistamines applied to the skin (such as diphenhydramine cream, ointment, spray) because increased side effects may occur.

Levocetirizine is very similar to hydroxyzine and cetirizine. Do not use these medications while using levocetirizine.

This medication may interfere with certain lab tests (such as allergy skin testing), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.

Does Xyzal interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe drowsiness. In children, mental/mood changes (such as restlessness, agitation) may occur before drowsiness.

Keep all regular medical and lab appointments.

If you are taking this medication on a regular schedule and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

Xyzal 5 mg tablet

Color: whiteShape: ovalImprint: X X

This medicine is a white, oval, scored, tablet imprinted with “X X”.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Xyzal: Uses, Dosage & Side Effects

Generic name: levocetirizine [ LEE-voe-se-TIR-a-zeen ]
Drug class: Antihistamines

Medically reviewed by Sanjai Sinha, MD. Last updated on Jan 4, 2023.

What is Xyzal?

Xyzal is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms such as a runny nose or hives.

Xyzal is used to treat symptoms of year-round (perennial) allergies in children who are at least 6 months old.

Xyzal is also used to treat itching and swelling caused by chronic urticaria (hives) in adults and children who are at least 6 months old.

Warnings

Before taking Xyzal, tell your doctor if you have liver disease, kidney disease, or gallbladder problems.

It is very important not to give a child more than the prescribed dose of Xyzal. A child’s body absorbs twice as much of the same dose size of levocetirizine as an adult’s body.

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Call your doctor if your symptoms do not improve, if they get worse, or if you also have a fever.

Before taking this medicine

You should not use Xyzal if you are allergic to levocetirizine or cetirizine (Zyrtec).

You should not take Xyzal if you have end-stage kidney disease or if you are on dialysis. Any child younger than 12 years old with kidney disease should not take levocetirizine.

Tell your doctor if you have ever had:

Levocetirizine is not expected to harm an unborn baby. Tell your doctor if you are pregnant.

You should not breast-feed while using this medicine.

Xyzal is not approved for use by anyone younger than 6 months old.

How should I take Xyzal?

Take Xyzal exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

A child’s dose of levocetirizine is based on the age of the child. Follow your doctor’s dosing instructions very carefully.

Do not give a child more than the prescribed dose of this medicine. A child’s body absorbs twice as much of the same dose size of levocetirizine as an adult’s body.

Taking more of this medication will not make it more effective, and may cause severe drowsiness.

Xyzal is usually taken in the evening, with or without food.

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Call your doctor if your symptoms do not improve, if they get worse, or if you also have a fever.

Store at room temperature away from moisture and heat.

Dosing information

Usual Adult Dose for Urticaria:

5 mg orally once a day in the evening

Comments: Some patients may be adequately controlled on 2.5 mg orally once a day in the evening.

Use: For the treatment of uncomplicated skin manifestations of chronic idiopathic urticaria

Usual Adult Dose for Allergic Rhinitis:

Seasonal Allergic Rhinitis (OTC): 5 mg orally once a day in the evening; some patients may be adequately controlled on 2.5 mg once a day

Usual Pediatric Dose for Allergic Rhinitis:

Perennial Allergic Rhinitis:
6 months to 2 years: 1. 25 mg orally once a day in the evening

Comments: The recommended dose in pediatric patients 6 months to 2 years should not be exceeded.

Use: For the relief of symptoms associated with perennial allergic rhinitis

Seasonal Allergic Rhinitis (OTC):
6 to 11 years: 2.5 mg orally once a day in the evening
12 years or older: 5 mg orally once a day in the evening; some patients may be adequately controlled on 2.5 mg once a day

Comments: Avoid use in patients less than 6 years.

Usual Pediatric Dose for Urticaria:

6 months to 5 years: 1.25 mg orally once a day in the evening
6 to 11 years: 2.5 mg orally once a day in the evening
12 years or older: 5 mg orally once a day in the evening; some patients may be adequately controlled on 2.5 mg once a day

Comments: The recommended doses in pediatric patients 6 months to 12 years should not be exceeded.

Use: For the treatment of uncomplicated skin manifestations of chronic idiopathic urticaria

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What to avoid

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Drinking alcohol with this medicine can cause side effects.

Xyzal side effects

Get emergency medical help if you have signs of an allergic reaction to Xyzal: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

• worsening allergy or urticaria symptoms;

• painful or difficult urination;

• little or no urination;

• a light-headed feeling, like you might pass out;

• fever; or

• signs of an ear infection – ear pain or full feeling, trouble hearing, drainage from the ear, fussiness in a child.

Common Xyzal side effects may include:

• drowsiness, tiredness;

• sinus pain;

• ear infection;

• cough;

• fever;

• nosebleed;

• vomiting, diarrhea, constipation;

• dry mouth; or

• weight gain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Xyzal?

Using Xyzal with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all your other medicines, especially:

• ritonavir; or

• theophylline.

This list is not complete. Other drugs may interact with levocetirizine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Popular FAQ

Yes, Xyzal Allergy 24HR is available without a prescription as an over-the-counter (OTC) product for treatment of symptoms due to seasonal and year-round allergies. Xyzal contains levocetirizine, an antihistamine previously only available with a prescription. Xyzal can be used at bedtime to relieve symptoms like runny nose, itchy eyes and throat, and sneezing throughout the next day. It can cause drowsiness. Continue reading

More about Xyzal (levocetirizine)

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Related treatment guides

• Urticaria
• Allergies
• Allergic Rhinitis

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Xyzal only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Copyright 1996-2023 Cerner Multum, Inc. Version: 5.01.

Instructions Xyzal film-coated tablets 5 mg №10

Expected

Available in 0 pharmacies

INSTRUCTIONS

for medical use of the drug

XYZAL ®

(XYZAL®)

Composition of the medicinal product:

active ingredient: levocetirizine;

1 tablet contains levocetirizine dihydrochloride 5 mg;

other ingredients: microcrystalline cellulose, anhydrous colloidal silicon dioxide, lactose monohydrate, magnesium stearate, Opadry® Y-1-7000 (hypromelose (E 464), titanium dioxide (E 171), macrogol 400).

Dosage form.

Film-coated tablets.

Film-coated tablets, white to off-white, oval, with Y logo on one side.

Manufacturer’s name and location.

1) Acica Pharmaceuticals S. R.L (primary and secondary packaging, manufacturer responsible for batch production and quality control).

Via Praglia, 15 – 10044 Pianezza (TO), Italy.

2) YUSB Farshim S.A. (manufacturer in bulk).

Z.I. de Planchu, Chemin de Croix Blanche 10, 1630 Bulle, Switzerland.

Pharmacotherapeutic group.

Antihistamines for systemic use. Piperazine derivatives. ATC code R06A E09.

Levocetirizine is an active stable R-enantiomer of cetirizine, belonging to the group of competitive histamine antagonists. Pharmacological action is due to the blocking of H1-histamine receptors. The affinity for H1-histamine receptors in levocetirizine is 2 times higher than that of cetirizine. It affects the histamine-dependent stage of the development of an allergic reaction, reduces the migration of eosinophils, vascular permeability, and limits the release of inflammatory mediators. It prevents the development and suppresses the course of allergic reactions, has anti-exudative, antipruritic, anti-inflammatory effects, almost no anticholinergic and antiserotonin effects.

Pharmacokinetic parameters of levocetirizine are linear and almost do not differ from those of cetirizine.

Absorption. After oral administration, the drug is rapidly and extensively absorbed. The degree of absorption of the drug does not depend on the dose and does not change with food intake, but the maximum concentration (Cmax) of the drug decreases and reaches its maximum value later. Bioavailability reaches 100%.

In 50% of patients, the effect of the drug develops 12 minutes after a single dose, and in 95% – after 0.5-1 hour. Smakh in blood serum is reached in 50 minutes after single intake of a therapeutic dose. The equilibrium concentration in the blood is reached after 2 days of taking the drug. Cmax is 270 ng/ml after a single dose and 308 ng/ml after repeated use at a dose of 5 mg, respectively.

Division. There is no information on the distribution of the drug in human tissues, as well as on the penetration of levocetirizine through the blood-brain barrier. In animal studies, the highest concentration is recorded in the liver and kidneys, and the lowest – in the tissues of the central nervous system. The volume of distribution is 0.4 l / kg. Plasma protein binding – 90%.

Biotransformation. About 14% of levocetirizine is metabolized in the human body. The metabolic process includes oxidation, N- and O-dealkylation and coupling with taurine. Dealkylation primarily occurs with the participation of cytochrome CYP 3A4, while numerous and (or) indefinite isoforms of CYP are involved in the process of oxidation. Levocetirizine does not affect the activity of cytochrome isoenzymes 1A2, 2C9, 2C19, 2D6, 2E1, 3A4 at concentrations significantly higher than the maximum after a dose.

5 mg orally. Given the low degree of metabolism and the lack of ability to inhibit metabolism, the interaction of levocetirizine with other substances (and vice versa) is unlikely.

Conclusion. Excretion of the drug occurs mainly due to glomerular filtration and active tubular secretion. The plasma half-life in adults (T1 / 2) is 7.9 + 1.9 hours. The half-life of the drug is shorter in young children. The total clearance in adults is 0.63 ml / min / kg. Basically, the excretion of levocetirizine and its metabolites from the body occurs with urine (an average of 85.4% of the drug dose is excreted). Only 12.9 is excreted with faeces% of the drug dose.

Apparent body clearance of levocetirizine correlates with creatinine clearance. Therefore, in patients with moderate to severe renal impairment, it is recommended to select the intervals between doses of levocetirizine, taking into account creatinine clearance. With anuria in end-stage kidney disease, the total body clearance of patients, compared with the total body clearance of individuals without such disorders, is reduced by about 80%. The amount of levocetirizine excreted during a standard 4-hour hemodialysis procedure was < 10%.

Indications for use.

Symptomatic treatment of allergic rhinitis (including perennial allergic rhinitis) and urticaria.

Contraindications.

Hypersensitivity to levocetirizine or to any other constituent of this dosage form, or to any piperazine derivatives.

Severe CKD (creatinine clearance < 10 ml/min).

Rare hereditary disorders of galactose intolerance, lactase deficiency or impaired absorption of glucose and galactose.

Appropriate safety precautions for use. Use with caution in patients with chronic renal failure (dosage adjustment is needed) and in elderly patients with renal insufficiency (glomerular filtration may be reduced). During the use of the drug should refrain from alcohol.

If patients have certain factors that provoke urinary retention (eg, spinal cord injury, prostatic hyperplasia), care should be taken when prescribing the drug, since levocetirizine may increase the risk of urinary retention.

Special reservations.

Use during pregnancy or lactation.

Levocetirizine is contraindicated for use during pregnancy. Cetirizine passes into breast milk, therefore, if necessary, the use of the drug, breast-feeding should be discontinued.

The ability to influence the reaction rate when driving vehicles or operating other mechanisms. You should refrain from driving vehicles or working with other mechanisms for the period of treatment with the drug.

Children. The drug in the form of tablets should not be used in children under 6 years of age, since this dosage form does not allow for the necessary correction of the dosing regimen. This category of patients is recommended to use levocetirizine in a dosage form suitable for use in pediatrics.

Dosage and administration.

The drug is prescribed for adults and children from 6 years old orally in a daily dose of 5 mg.

1 time per day. Take the tablet with or without food. The tablet must be swallowed whole with a small amount of water.

Elderly patients with normal renal function dose adjustment is not required. Patients with impaired renal function should calculate the dose taking into account creatinine clearance according to the table.

To apply this dosage table, the patient’s creatinine clearance (CLcr) in ml/min must be estimated. CLcr (ml/min) should be estimated from serum creatinine (mg/dl) using the following formula:

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XIZAL : instruction, reviews, analogues, price in pharmacies

• Indications for use
• Method of application
• Side effects
• Contraindications
• Pregnancy
• Interaction with other drugs
• Overdose
• Storage conditions
• Presentation form
• Ingredients

Xyzal is the original antihistamine from UCB.
Xyzal is a drug with a pronounced antihistamine and antiallergic effect. The active ingredient in Xyzal, levocetirizine, is the R-enantiomer of cetirizine. Levocetirizine competitively blocks H1-histamine receptors, and the pharmacological activity of levocetirizine is almost 2 times higher than that of cetirizine.
Xyzal affects the histamine-dependent phase of an allergic reaction. In addition, levocetirizine leads to a decrease in the migration of eosinophils and a decrease in the permeability of the vascular wall. Xyzal also somewhat slows down the release of cytokines and inflammatory mediators.
The drug has antipruritic and anti-exudative action, facilitates the course and prevents the development of allergic reactions. Levocetirizine has practically no effect on cholinergic and serotonin receptors, and does not have a significant sedative effect.
After oral administration, levocetirizine is well absorbed in the intestinal tract. Taking the drug simultaneously with food intake does not lead to a change in the bioavailability and absorption rate of levocetirizine. The peak plasma concentration of the active substance is reached within 1 hour after ingestion. Equilibrium plasma concentrations are reached on the second day of therapy with levocetirizine.
The degree of connection of levocetirizine with plasma proteins reaches 90%, oral bioavailability of 100%. Slightly metabolized in the body. It is excreted mainly by the kidneys by tubular secretion and glomerular filtration. About 13% of levocetirizine is excreted by the intestines. The elimination half-life varies from 6 to 10 hours, depending on the individual characteristics of the patient. In children, the half-life of levocetirizine is shortened.
In patients with impaired renal function, an increase in the half-life is noted. During hemodialysis, levocetirizine is practically not excreted (during a 4-hour hemodialysis, no more than 10% of levocetirizine is excreted).
The active ingredient of Xyzal passes into breast milk.

Indications for use

Xyzal is intended for the symptomatic treatment of patients suffering from year-round and seasonal form of allergic conjunctivitis and rhinitis, which are accompanied by sneezing, swelling of the nasal mucosa, lacrimation, rhinorrhea and hyperemia of the nasal mucosa and conjunctiva.
Ksizal is also prescribed to patients suffering from hay fever, chronic idiopathic urticaria, angioedema and allergic dermatosis, which are accompanied by skin rash and itching.

Directions for use

film-coated tablets Xyzal :
The preparation is intended for oral use. It is not recommended to crush or chew the tablet. Xyzal is taken with or without food, the tablet should be washed down with a small amount of drinking water. The duration of the course of treatment and the dose of levocetirizine is determined by the attending physician.
Adults and children over 6 years of age are usually prescribed 1 tablet of Xyzal per day.
For children under 6 years of age, it is recommended to prescribe the drug in the form of oral drops.
Patients with reduced renal function should adjust the dose of levocetirizine:
With creatinine clearance from 30 to 50 ml / min, as a rule, 1 tablet of Xyzal is prescribed once every 48 hours.
For creatinine clearance between 10 and 30 ml/min, 1 tablet of Xyzal is usually given every 72 hours.
With creatinine clearance less than 10 ml / min (patients on hemodialysis), levocetirizine is not used.
With normal renal function in elderly patients and patients with impaired liver function, the dose of levocetirizine does not need to be adjusted.
The duration of treatment is from 1 week to 6 months, depending on the nature of the disease. In some cases, the course is extended up to 12 months under the supervision of a physician.

Oral drops Xyzal :
The drug is taken orally, regardless of food intake. If necessary, the required number of drops is diluted in a small amount of drinking water (no more than 10 ml). The duration of administration and dose of Xyzal is determined by the doctor.
Adults and children over 6 years of age are usually given 20 drops of Xyzal per day. The daily dose is recommended to be taken in 1 dose.
Children 2 to 6 years of age are usually given 5 drops of Xyzal twice daily.
The maximum recommended daily dose of levocetirizine for adults and children over 6 years of age is 5 mg.
The maximum recommended daily dose of levocetirizine for children aged 2 to 6 years is 2.5 mg.

In patients with impaired renal function, dose selection of levocetirizine should be carried out taking into account indicators of creatinine clearance:
Patients with creatinine clearance from 30 to 50 ml / min, as a rule, are prescribed 20 drops of Xyzal 1 time in 48 hours.
Patients with creatinine clearance between 10 and 30 ml/min are usually given 20 drops of Xyzal once every 72 hours.
Levocetirizine is not prescribed to patients on hemodialysis.
Elderly patients and patients with impaired liver function with normal renal function dose adjustment of levocetirizine is not required.
The duration of therapy is usually 1 week to 6 months. In some cases, under the close supervision of a doctor, the course of treatment can be increased up to 18 months.

Side effects

Xyzal is generally well tolerated by patients. During therapy with levocetirizine, some patients noted the development of such undesirable effects:
From the sensory organs and the central nervous system: decreased visual acuity, drowsiness, fatigue, headache, aggression, asthenia, depression.

In isolated cases, hallucinations and convulsions may develop.
From the gastrointestinal tract and hepatobiliary system: discomfort and pain in the epigastric region, dryness of the oral mucosa, nausea, diarrhea, hepatitis, elevated liver enzymes. In isolated cases, there was a change in body weight.
Allergic reactions: urticaria, pruritus and rash, anaphylactic shock, angioedema.
Others: palpitations, dyspnea, shortness of breath, muscle pain.

Contraindications

:
Xyzal is not prescribed for patients with individual hypersensitivity to levocetirizine and piperazine derivatives.
Film-coated tablets, Xyzal is not recommended for use in patients with glucose-galactose malabsorption syndrome, galactosemia and lactase deficiency.
Levocetirizine should not be prescribed to patients with severe renal insufficiency (creatinine clearance less than 10 ml / min).
Xyzal is not recommended for use during pregnancy and lactation.
Coated tablets are not for use in children under 6 years of age.
Do not use oral drops in children under 2 years of age.
Caution is advised when prescribing levocetirizine to patients with impaired renal function, chronic alcoholism, and elderly patients.
Patients who drive a car or operate potentially unsafe mechanisms should be especially careful during treatment with levocetirizine.

Pregnancy

:
Xyzal is not used for the treatment of women during pregnancy, due to the lack of reliable data on the effect of levocetirizine on the fetus and pregnancy.
During lactation, the appointment of the drug Ksizal is possible only after deciding on the abolition of breastfeeding, since levocetirizine passes into breast milk.

Interaction with other drugs

There may be some increase in the half-life of levocetirizine when used in combination with theophylline.
The combined use of levocetirizine with ethyl alcohol and drugs that depress the central nervous system is not recommended.

Overdose

:
Taking high doses of levocetirizine may cause unreasonable restlessness, agitation or drowsiness. In addition, it is possible to increase the severity of undesirable effects.
There is no specific antidote. When taking high doses of the drug Xyzal , you should immediately wash the stomach and prescribe enterosorbents. If necessary, carry out therapy aimed at eliminating the symptoms of intoxication.
Carrying out hemodialysis with an overdose of levocetirizine is ineffective.

Storage conditions

Oral drops Xyzal should not be stored for more than 2 years after manufacture.
Xyzal film-coated tablets should not be stored for more than 3 years after manufacture.