The Endocrine System and Glands of the Human Body: Function and Disorders

Written by Barbara Brody

• What Is the Endocrine System?
• What Is a Gland?
• Endocrine System Functions
• Parts of the Endocrine System
• Health Issues
• Endocrine System Disorders
• More

The endocrine system is a network of glands in your body that make the hormones that help cells talk to each other. They’re responsible for almost every cell, organ, and function in your body.

If your endocrine system isn’t healthy, you might have problems developing during puberty, getting pregnant, or managing stress. You also might gain weight easily, have weak bones, or lack energy because too much sugar stays in your blood instead of moving into your cells where it’s needed for energy.

A gland is an organ that makes and puts out hormones that do a specific job in your body. Endocrine and exocrine glands release the substances they make into your bloodstream.

Your endocrine system:

• Makes hormones that control your moods, growth and development, metabolism, organs, and reproduction
• Controls how your hormones are released
• Sends those hormones into your bloodstream so they can travel to other body parts

Many glands make up the endocrine system. The hypothalamus, pituitary gland, and pineal gland are in your brain. The thyroid and parathyroid glands are in your neck. The thymus is between your lungs, the adrenals are on top of your kidneys, and the pancreas is behind your stomach. Your ovaries (if you’re a woman) or testes (if you’re a man) are in your pelvic region.

• Hypothalamus. This organ connects your endocrine system with your nervous system. Its main job is to tell your pituitary gland to start or stop making hormones.
• Pituitary gland. This is your endocrine system’s master gland. It uses information it gets from your brain to tell other glands in your body what to do. It makes many important hormones, including growth hormone; prolactin, which helps breastfeeding moms make milk; antidiuretic hormone(ADH) (vasopressin), which controls blood pressure and helps control body water balance through its effect on the kidney, corticotropin /ACTH: Adrenocorticotrophic hormone. which stimulates the adrenal gland to make certain hormones, thyroid-stimulating hormone (TSH), which stimulates the production and secretion of thyroid hormones, oxytocin which helps in milk ejection during breast feeding; and luteinizing hormone, which manages estrogen in women and testosterone in men.
• Pineal gland. It makes a chemical called melatonin that helps your body get ready to go to sleep.
• Thyroid gland. This gland makes thyroid hormone, which controls your growth and metabolism. If this gland doesn’t make enough (a condition called hypothyroidism), everything happens more slowly. Your heart rate might slow down. You could get constipated. And you might gain weight. If it makes too much (hyperthyroidism), everything speeds up. Your heart might race. You could have diarrhea. And you might lose weight without trying. The thyroid gland also produces the hormone calcitonin, which may contribute to bone strength by helping calcium to be incorporated into bone.
• Parathyroid. This is a set of four small glands behind your thyroid. They play a role in bone health. The glands control your levels of calcium and phosphorus.
• Thymus. This gland makes white blood cells called T-lymphocytes that fight infection and are crucial as a child’s immune system develops. The thymus starts to shrink after puberty.
• Adrenals. Best known for making the “fight or flight” hormone adrenaline (also called epinephrine), these two glands also make hormones called corticosteroids. They affect your metabolism heart rate, oxygen intake, blood flow, and sexual function, among other things.
• Pancreas. This organ is part of both your digestive and endocrine systems. It makes digestive enzymes that break down food. It also makes the hormones insulin and glucagon. These ensure you have the right amount of sugar in your bloodstream and your cells.
• If you don’t make insulin, which is the case for people with type 1 diabetes, your blood sugar levels can get dangerously high. In type 2 diabetes, the pancreas usually makes some insulin but not enough.
• Ovaries. In women, these organs make estrogen and progesterone. These hormones help develop breasts at puberty, regulate the menstrual cycle, and support a pregnancy.
• Testes. In men, the testes make testosterone. It helps them grow facial and body hair at puberty. It also tells the penis to grow larger and plays a role in making sperm.

As you get older, it’s natural to notice some things related to your endocrine system. Your metabolism tends to slow down. So you might gain weight even though you haven’t changed how you eat or exercise. Hormonal shifts also explain, at least in part, why you’re more likely to have heart disease, osteoporosis, and type 2 diabetes as you age.

No matter how old you are, stress, infections, and being around certain chemicals can also mess with parts of your endocrine system. And genetics or lifestyle habits can increase your chances of an endocrine disorder like hypothyroidism, diabetes, or osteoporosis.

• Acromegaly. Sometimes the pituitary gland makes too much growth hormone and your bones get bigger. It usually affects your hands, feet, and face. It usually starts in middle age.
• Adrenal insufficiency. When you have this, your adrenal glands don’t make enough of certain hormones, like cortisol, which controls stress.
• Cushing’s disease. In this, your body makes too much cortisol. You could gain weight, get stretch marks, bruise easily at first, then get weakened muscles and bones and possibly develop a hump on your upper back.
• Hyperthyroidism. This is when your thyroid gland makes more hormones than your body needs. You might hear it called overactive thyroid. It makes your system run fast and you might feel nervous, lose weight, and have a rapid heartbeat or trouble sleeping.
• Hypothyroidism. When your body doesn’t make enough thyroid hormone, your system slows down. You might feel tired, gain weight, have a slow heartbeat, and get joint and muscle pains.
• Hypopituitarism. Sometimes your pituitary gland doesn’t make enough of certain hormones and your adrenal and thyroid glands can’t work right.
• Multiple endocrine neoplasia. This is a group of disorders that affect your endocrine system. It causes tumors on at least two endocrine glands or in other organs and tissues.
• Polycystic ovary syndrome. An imbalance of reproductive hormones can cause your ovaries to either not make an egg or not release it during ovulation. This can throw off your periods, cause acne, and make hair to grow on your face or chin.
• Precocious puberty. When glands that control reproduction don’t work properly, some kids start puberty abnormally early — around 8 in girls and 9 in boys.

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What Is It, Functions, Organs & Conditions

The endocrine system is a network of glands and organs located throughout the body. It’s similar to the nervous system in that it plays a vital role in controlling and regulating many of the body’s functions.

However, while the nervous system uses nerve impulses and neurotransmitters for communication, the endocrine system uses chemical messengers called hormones.

Keep reading to discover more about the endocrine system, what it does, and the hormones it produces.

The endocrine system is responsible for regulating a range of bodily functions through the release of hormones.

Hormones are secreted by the glands of the endocrine system, traveling through the bloodstream to various organs and tissues in the body. The hormones then tell these organs and tissues what to do or how to function.

Some examples of bodily functions that are controlled by the endocrine system include:

• metabolism
• growth and development
• sexual function and reproduction
• heart rate
• blood pressure
• appetite
• sleeping and waking cycles
• body temperature

What is a gland?

A gland is an organ that creates and releases substances that the body needs to function. There are two types of glands:

• endocrine glands, which release hormones directly into the bloodstream
• exocrine glands, like lymph nodes and sweat glands, which are not part of the endocrine system

The glands of the endocrine system are where hormones are produced, stored, and released. Each gland produces one or more hormones, which go on to target specific organs and tissues in the body.

The glands of the endocrine system include the:

• Hypothalamus. While some people don’t consider it a gland, the hypothalamus produces multiple hormones that control the pituitary gland. It’s also involved in regulating many functions, including sleep-wake cycles, body temperature, and appetite. It can also regulate the function of other endocrine glands.
• Pituitary. The pituitary gland is located below the hypothalamus. The hormones it produces affect growth and reproduction. They can also control the function of other endocrine glands.
• Pineal. This gland is found in the middle of your brain. It’s important for your sleep-wake cycles.
• Thyroid. The thyroid gland is located in the front part of your neck. It’s very important for metabolism.
• Parathyroid. Also located in the front of your neck, the parathyroid gland is important for maintaining control of calcium levels in your bones and blood.
• Thymus. Located in the upper torso, the thymus is active until puberty and produces hormones that are important for the development of a type of white blood cell called a T cell.
• Adrenal. One adrenal gland can be found on top of each kidney. These glands produce hormones that are important for regulating functions such as blood pressure, heart rate, and stress response.
• Pancreas. The pancreas is located in your abdomen behind your stomach. Its endocrine function involves controlling blood sugar levels.

Some endocrine glands also have non-endocrine functions. For example, the ovaries and testes produce hormones, but they also have the non-endocrine function of producing eggs and sperm, respectively.

Hormones are the chemicals the endocrine system uses to send messages to organs and tissue throughout the body. Once released into the bloodstream, hormones travel to their target organ or tissue, which has receptors that recognize and react to the hormone.

Below are some examples of hormones that are produced by the endocrine system.

Explore the interactive 3-D diagram below to learn more about the endocrine system.

Sometimes, hormone levels can be too high or too low. When this happens, it can have a number of effects on your health. The signs and symptoms depend on the hormone that’s out of balance.

Here’s a look at some conditions that can affect the endocrine system and alter your hormone levels.

Hyperthyroidism

Hyperthyroidism happens when your thyroid gland makes more thyroid hormone than necessary. This can be caused by a range of things, including autoimmune conditions.

Some common symptoms of hyperthyroidism include:

• fatigue
• nervousness
• weight loss
• diarrhea
• issues tolerating heat
• fast heart rate
• trouble sleeping

Treatment depends on how severe the condition is, as well as its underlying cause. Options include medications, radioiodine therapy, or surgery.

Graves‘ disease is an autoimmune disorder and a common form of hyperthyroidism. In people with Graves‘ disease, the immune system attacks the thyroid, which causes it to produce more thyroid hormone than usual.

Hypothyroidism

Hypothyroidism occurs when your thyroid doesn’t produce enough thyroid hormone. Similar to hyperthyroidism, it has many potential causes.

Some common symptoms of hypothyroidism include:

• fatigue
• weight gain
• constipation
• issues tolerating the cold
• dry skin and hair
• slow heart rate
• irregular periods
• fertility issues

Treatment for hypothyroidism involves supplementing your thyroid hormone with medication.

Cushing syndrome

Cushing syndrome happens due to high levels of the hormone cortisol.

Common symptoms of Cushing syndrome include:

• weight gain
• fatty deposits in the face, midsection, or shoulders
• stretch marks, particularly on the arms, thighs, and abdomen
• slow healing of cuts, scrapes, and insect bites
• thin skin that bruises easily
• irregular periods
• decreased sex drive and fertility in males

Treatment depends on the cause of the condition and can include medications, radiation therapy, or surgery.

Addison’s disease

Addison’s disease happens when your adrenal glands don’t produce enough cortisol or aldosterone. Some symptoms of Addison’s disease include:

• fatigue
• weight loss
• abdominal pain
• low blood sugar
• nausea or vomiting
• diarrhea
• irritability
• a craving for salt or salty foods
• irregular periods

Treatment for Addison’s disease involves taking medications that help replace the hormones your body isn’t producing enough of.

Diabetes

Diabetes refers to a condition in which your blood sugar levels aren’t regulated within a certain range.

People with diabetes have too much glucose in their blood (high blood sugar). There are two types of diabetes: type 1 diabetes and type 2 diabetes.

Some common symptoms of diabetes include:

• fatigue
• increased hunger or thirst
• frequent urge to urinate
• irritability
• frequent infections

Treatment for diabetes can include blood sugar monitoring, insulin therapy, and medications. Lifestyle changes, such as getting regular exercise and eating a balanced diet, can also help.

Polycystic ovary syndrome (PCOS)

This common condition is caused by unbalanced reproductive hormones in people with ovaries, which can create issues in the ovaries. Living with PCOS can mean that an egg may not be released every month, or may not develop as it should when it is released.

Some of the common symptoms of PCOS are:

• irregular periods
• fertility issues
• cysts that form on the ovaries
• acne
• hirsutism, which is an unusual amount of hair growth on the face or chin
• thinning hair
• weight gain
• skin tags

Treatment for PCOS focuses on easing the symptoms. Treatments include medications, like birth control and metformin, and lifestyle changes, such as focusing on nutrition and trying to reach a moderate weight if your doctor has recommended it.

Hypogonadism

A common condition, especially in older males and occasionally in females, hypogonadism is caused by a lowered production of the sex hormone testosterone. This can lead to lowered libido, as well as a variety of other symptoms, such as:

• erectile dysfunction in people with a penis
• reduced energy
• reduced muscle mass
• depressed mood
• increased irritability

Treatment for hypogonadism focuses on improved testosterone levels. Testosterone replacement therapy and lifestyle changes (such as working toward a moderate weight if your doctor has recommended it) are two popular methods.

Osteoporosis

Osteoporosis is an abnormal loss of bone mass and changes in bone tissue. It can be caused by a variety of issues, but two common causes are lowered estrogen levels in people with ovaries and lowered testosterone levels in people with testicles. These lowered hormone levels can be caused by age, as well as other diseases.

Osteoporosis doesn‘t always cause obvious symptoms. But some of the more common symptoms are bone fractures and injuries related to minor falls, lifting, and even coughing.

Treatment for osteoporosis focuses on slowing or stopping bone loss. Proper nutrition, exercise, and medications are three of the most common treatments.

Acromegaly

This rare disease is caused when the body makes too much growth hormone, which is mainly produced in the pituitary gland. Mostly diagnosed in middle-aged adults, it can cause organs, bones, cartilage, organs, and certain tissues to grow in size.

The common symptoms of acromegaly include:

• swollen nose
• swollen ears
• swollen hands and feet
• joint aches
• a deeper voice than usual
• an increase in sweating and body odor

Treatment for acromegaly includes medications, radiation therapy, and surgery.

The endocrine system is a complex collection of glands and organs that helps regulate various bodily functions. This is accomplished through the release of hormones, or chemical messengers, produced by the endocrine system.

What is the endocrine system – an explanation of glands and hormones

The endocrine system is a system of glands that produce and release hormones into the blood. These hormones control many of the body’s vital functions such as growth, metabolism, and reproduction.

What is the endocrine system?

The endocrine system is very complex and scientists are still learning a lot about how it works. But we do know that the circulatory system plays an important role in delivering hormones to target tissues.

The endocrine system includes many different glands. These include the pituitary gland, thyroid gland, adrenal glands, and pancreas. Each gland produces specific hormones that help regulate various bodily functions. For example, the pituitary gland produces growth hormone, which allows the body to grow and develop. The thyroid gland produces thyroxine, which helps regulate metabolism. The adrenal glands produce adrenaline, which helps mobilize the body’s resources during times of stress.

Body glands

There are many different glands in the body, each with a specific function. Endocrine glands produce hormones – chemicals that regulate the growth, metabolism and reproduction of the body.

Pituitary gland

The pituitary gland is located at the base of the brain; this gland produces growth hormone, which regulates the growth of the body. The pituitary gland is also responsible for the production of other hormones such as adrenocorticotropic hormone (ACTH), which controls the production of stress hormones in the adrenal glands. Fight or flight, the system that can make us feel stressed or anxious, is controlled by the pituitary gland.

Hypothalamus

The hypothalamus is located just below the thalamus, in the center of the brain. It produces a variety of hormones, including corticotropin-releasing hormone (CRH), which regulates the production of stress hormones in the adrenal glands. The hypothalamus also regulates body temperature, hunger, thirst and fatigue.

Thyroid gland

The thyroid gland is located in the front of the neck, just below the vocal apparatus (larynx). It produces thyroid-stimulating hormone, which regulates the body’s metabolism. Thyroid hormone helps the body convert food into energy and plays a role in growth and development.

Parathyroid gland

The parathyroid gland is located in the neck, behind the thyroid gland. It produces parathyroid hormone, which helps regulate calcium levels in the body. Calcium is essential for many functions, including muscle contraction, nerve function, and blood clotting.

Adrenal glands

The adrenal glands sit above the kidneys and produce stress hormones such as adrenaline and cortisol. These hormones help the body respond to stressful situations.

Pancreas

The pancreas is located in the abdomen, behind the stomach. It produces insulin, a hormone that helps regulate blood sugar levels. The pancreas also produces other hormones, such as glucagon, which help regulate metabolism.

Pineal gland

The pineal gland is located in the brain, in the center of the head. It produces melatonin, a hormone that helps regulate sleep. The pineal gland also helps regulate the circadian rhythm, or the body’s internal clock.

Reproductive glands (ovaries and testes)

Ovaries and testicles are the main reproductive glands. The ovaries produce eggs that are necessary for fertilization. They also produce hormones such as estrogen and progesterone that play a role in reproduction.

The testicles produce sperm, which is necessary for fertilization. They also produce testosterone, a hormone that helps regulate male characteristics such as muscle mass and hair growth.

Hormones

Now that we have discussed the glands of the body, let’s talk about hormones. As we have already said, hormones are chemicals that regulate the growth, metabolism and reproduction of the body. They are produced by the endocrine glands and enter the bloodstream. Through the blood, hormones enter target tissues, where they bind to specific receptors. Binding of hormones to receptors causes a response in target tissues.

There are many different hormones in the body, each with a specific function. Some of the most important hormones include:

Adrenaline (stress hormone)

Adrenaline increases heart rate, blood pressure and blood sugar, which gives the body extra energy to cope with a stressful situation

Cortisol (stress hormone)

Cortisol helps the body respond to stress by regulating metabolism substances, blood sugar levels and immune function.

Estrogen

Estrogen regulates the menstrual cycle and promotes the development of feminine features such as breasts and hips. Estrogen also protects bone health.

Progesterone

Progesterone prepares the body for pregnancy by thickening the lining of the uterus and also plays a role in the production of breast milk.

Testosterone

Testosterone promotes the development of male qualities such as muscle mass and hair growth; it also regulates sex drive.

Thyroid hormone

Thyroid hormone regulates the body’s metabolism, which is the process of converting food into energy. It also controls the activity of the nervous system.

Insulin

Insulin regulates blood sugar by helping the body store and use glucose (sugar). Many other hormones in the body play an important role in regulating growth, metabolism, and reproduction.

Hormone imbalance

A hormonal imbalance occurs when there is too much or too little of a hormone in the body. Hormone imbalances can lead to various health problems, including infertility, obesity, and diabetes.

There are several ways to correct hormonal imbalances. One of them is hormone replacement therapy, which involves taking hormones in pill form. Another way is surgery to remove a gland that is not functioning properly. Finally, some hormonal imbalances can be treated with lifestyle changes such as diet and exercise.

Circulatory system

The circulatory system is essential for the proper functioning of the endocrine system and is responsible for transporting hormones throughout the body. Circulating blood delivers hormones to target tissues by binding to specific receptors. Binding of hormones to receptors causes a response in target tissues. Without the circulatory system, hormones would not be able to reach their target tissues and perform their functions.

There are two main types of circulation in the body: The first is systemic circulation: it carries oxygen-rich blood to the tissues of the body. Pulmonary circulation: Carries carbon dioxide-rich blood from body tissues to the lungs.

People also ask about the endocrine system

What are hormones?

Hormones are chemical molecules produced by the endocrine glands. These hormones travel through the bloodstream and bind to specific receptors on target cells. This binding elicits a response in target cells that can be anything from stimulating cell growth to regulating metabolism.

Hormones are important for many vital bodily functions, including growth, metabolism and reproduction. Imbalances in hormone levels can lead to various health problems.

What are endocrine diseases?

Endocrine disorders occur when there is an imbalance of hormones in the body. This may be due to dysfunction of one or more endocrine glands, or to problems with the hormones themselves. Common endocrine diseases include diabetes, hypothyroidism, and adrenal insufficiency. Treatment for endocrine disorders often includes medication, lifestyle changes, or surgery.

How can I help regulate my hormones?

There are some simple strategies to help you regulate your hormone levels, including being physically active, maintaining a healthy weight, eating a balanced protein diet, reducing stress through activities such as meditation or yoga, and getting enough sleep.

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ReSources

Anatomy of the endocrine system | Johns Hopkins Medicine

Endocrine system: What it is, functions and organs

Hormones and the endocrine system | Johns Hopkins Medicine

Endocrine System: What it is, Functions, Organs and Conditions

Reproductive Glands – Encyclopedia of Health – University of Rochester Medical Center

10 Natural Ways to Balance Hormones

Endocrine System – ONA Medical Association

Endocrine naya system ensures stable operation the human body in a continuously changing environment, its protection from stress.

The endocrine system includes the following main organs: hypothalamus, pituitary gland, thyroid gland, mammary gland, adrenal glands, pancreas, ovaries (testes in men), gallbladder and appendix. ES organs are glands that provide growth, physiological development, reproductive functions of a person, as well as the course of the most important processes of balancing the activity of the whole organism under continuously changing external influences. Management of all this work and control over the correctness of its implementation is carried out in the body by hormones, which are produced by the glands of the ES. Each hormone is responsible for its own organs and functions, but works in a delicate balance with hormones produced by other glands. Depending on the function being performed at the moment, a different balance of hormones is required. Its failure causes disruption of the corresponding systems, organs, the flow of necessary reactions, which leads to the appearance of abnormalities in the body, and then diseases. Therefore, regular monitoring of hormonal levels is the key to the timely detection of violations and their curability. Another feature of ES should be noted: the interconnection and interdependence of its glands is so great that a violation found in one of the organs almost automatically means the presence of problems in others – after all, there is a hormonal failure.

Endocrine glands (EG) do not have excretory ducts, and the substances they secrete (hormones) enter directly into the blood and lymph. By sending hormones into the blood, EJs create a communication system and control the work of literally every cell in the body. Hormones provide its chemical balance, give the cells an indication of how to act, given their abilities and capabilities. The purpose of the EJ is to ensure the well-being of the whole organism, the balance in the work of internal organs, regardless of changes in the external environment, to protect the body from the destructive effects of stress.

Hypothalamus. Regulates the temperature reaction, establishes the correct ratio between heat release and heat transfer, controls the pituitary gland.

Pituitary gland. Manages the operation of the entire system. Incoming and outgoing messages are coordinated and make the ES work efficiently and harmoniously. The pituitary gland controls the body’s chemical balance by influencing most of the body’s chemical processes (for example, regulating water-salt and fat metabolism).

There is a constant need for the body to adapt to external changes, and this is also part of the task of the pituitary gland. The human body grows, wears out, and the pituitary gland is engaged in ensuring growth and repair. In addition, it provides reproductive function.

The pituitary gland performs its functions with the help of hormones that stimulate other endocrine glands. Those, in turn, secrete hormones that affect the pituitary gland itself and the nervous system. What happens in the body when the production of only one hormone is disrupted can be seen in the example of growth hormone. If it is produced more than the norm, a person becomes a victim of gigantism, if it is less than the norm, he remains a dwarf.

The pituitary gland is called the conductor of the ES, and sometimes its “brain”.

Thyroid. If the pituitary gland is the conductor of ES, then the thyroid gland (TG) is its metronome. It kind of sets the pace for all the cells of the body. The main function of the thyroid gland is to control the proper metabolism, the absorption of oxygen. It can speed up the metabolism if it increases the amount of hormones sent to the blood stream, or slow it down by reducing their amount. However, this does not happen, since its work is under the control of thyroid-stimulating hormone secreted by the pituitary gland. And that, in turn, manages the thyroid hormone, which provides feedback to the pituitary gland. That is, between the pituitary gland and the thyroid gland, there is a self-regulating mechanism of balance and control, working in a certain cycle.

Normal thyroid function promotes growth, puberty, childbearing, mental development, emotional balance, vitality.

Adrenal glands. Their bark is actually a gland, also called adrenal. It produces adrenaline, which increases vascular tone and blood pressure. The adrenal cortex affects the performance of the body, its resistance to stress. Women’s adrenal glands also help the ovaries – they also produce sex hormones. Moreover, during menopause, when the ovaries stop their production.

Pancreas. It produces insulin, which enhances the process of burning glycogen in muscles, which proceeds with the release of energy.

Gallbladder. During stress, it releases bile, as a result of which the peristalsis of the small intestine increases, the rotting masses are quickly pushed into the large intestine, into the rectum. There is an accelerated release of toxins, thereby preventing their entry into the blood.

Appendix. At the moment of stress, the release of the hormone occurs, as a result of which the peristalsis of the large intestine increases and the rotting masses are released through the rectum (often this process is called “bear disease”).

Ovaries. In the broadest sense, the ovaries provide a woman with femininity. They perform this function with the help of two main hormones: estrogen and progesterone. Progesterone promotes fertility, while estrogen provides other signs of femininity, including the complex function of the menstrual cycle. And when the ovaries reduce its secretion, menopause occurs.

Hormones. This is a Greek word meaning “I excite,” “I set into action.” These are a kind of chemical messages, ordering the actions of certain organs. The hormone does not explain to the cells what kind of work they should do, but only determines how much and how quickly it should be done. Each hormone has its own controlled organs, but circulating through the body, it affects others, having a specific and general effect.

The pituitary gland produces three main hormones: gonadotropic (stimulates the ovaries and sex glands) and mammotropic or prolactin (affects the mammary glands, promotes the formation of milk after the birth of a child) and thyrotropic.