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2400 mg ibuprofen: High-dose ibuprofen (≥2400mg/day): small increase in cardiovascular risk

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skeboz69 (@squeezeboz23)’s videos with Break Stuff – Limp Bizkit | TikTok

TikTok video from skeboz69 (@squeezeboz23). well I’ve taken 2400 mg of ibuprofen with no relief I’m stopping by my chiropractor on the way home see if he’ll do something if not try my Dr is she’s not in it’s off to the ER I go GOD I HATE HOSPITALS Break Stuff – Limp Bizkit.

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Break Stuff – Limp Bizkit

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Doc Alina👩🏼‍⚕️

Habt ihr euch die Frage auch schon gestellt? Hier ist die Antwort 💊 #medizin #ibuprofen #schmerzmittel #pharma #LernenmitTikTok #docalina #medizinstudent #drhouse #greys #interessantefakten #arzt #kopfweh #fitness

125K Likes, 1. 2K Comments. TikTok video from Doc Alina👩🏼‍⚕️ (@docxalina): “Habt ihr euch die Frage auch schon gestellt? Hier ist die Antwort 💊 #medizin #ibuprofen #schmerzmittel #pharma #LernenmitTikTok #docalina #medizinstudent #drhouse #greys #interessantefakten #arzt #kopfweh #fitness”. vs. | 2 💊💊 Ibuprofen 400mg | 1 💊 Ibuprofen 800mg | …💊 Ibu 400mg vs.
💊💊 Ibu 800mg As It Was – Harry Styles.

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As It Was – Harry Styles

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takeurmadz_

takeurmadz_ (@takeurmadz_)’s videos with original sound – Solo | TikTok

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original sound – Solo

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Dr. M

يتميز البروفين بفعاليته ضد الالتهابات عن الباراسيتامول. بينما ممكن استخدام كلاهما كمسكن و خافض حراره#طريقة_استعمال_باراسيتامول #بروفين #مسكنات_الالم #خافضات_الحراره #yourtiktokpharmacist #ibuprofen #paracetamol💊 #painkillers #antipyretic

84 Likes, TikTok video from Dr. M (@dr.m.pharmacist): “يتميز البروفين بفعاليته ضد الالتهابات عن الباراسيتامول. بينما ممكن استخدام كلاهما كمسكن و خافض حراره#طريقة_استعمال_باراسيتامول #بروفين #مسكنات_الالم #خافضات_الحراره #yourtiktokpharmacist #ibuprofen #paracetamol💊 #painkillers #antipyretic”. استخدامات
Ibuprofen بروفين و Paracetamolباراسيتامول | Paracetamol
باراسيتامول | خافض للحراره | …Ibuprofen بروفين و paracetamol باراسيتامول Calm Down – Rema.

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Calm Down – Rema

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Jessica Haggy

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TikTok video from Jessica Haggy (@jessicaraneehaggy): “😵‍💫 don’t do this #fyp #TheAdamProject”. Thinking about how I would take 2000 mg of ibuprofen at a time most days because i thought it had no side effects….Crazy Crazy – Patsy Cline.

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Crazy – Patsy Cline

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Your Health Buddy 🤝

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Taking high doses of IBUPROFEN can have dangerous consequences on pregnant mothers like; | Follow for more tips | miscarriage | …Ibuprofen Abracadabra – Rexxie & Naira Marley & Skiibii.

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Abracadabra – Rexxie & Naira Marley & Skiibii

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Nyrah Pharmacist

Did you know these facts about #ibuprofen ? #learnwithnyrah #pharmacy #pharmacist #nurse #medicine #pharmacology #doctor #medicine #painrelief

7. 5K Likes, 143 Comments. TikTok video from Nyrah Pharmacist (@healthwithnyrah): “Did you know these facts about #ibuprofen ? #learnwithnyrah #pharmacy #pharmacist #nurse #medicine #pharmacology #doctor #medicine #painrelief”. YOU NEED TO KNOW THIS | IBUPROFEN 💊 FACTS | It reduces the ability of your body to make prostaglandins — chemicals that promote pain, inflammation and fever. | … original sound – Nyrah Pharmacist.

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original sound – Nyrah Pharmacist

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Not Marjorie

Replying to @danaa_smith fine is relative #psa #toxic #otc #badmedicine #themoreyouknow #healthcare #medtok #pharmtok #apothescary #dosing #guidelines

572 Likes, 64 Comments. TikTok video from Not Marjorie (@deesknots): “Replying to @danaa_smith fine is relative #psa #toxic #otc #badmedicine #themoreyouknow #healthcare #medtok #pharmtok #apothescary #dosing #guidelines”. Fine Already Dumb Ways to Die – Tangerine Kitty.

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Dumb Ways to Die – Tangerine Kitty

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Austin

It just hits…different #euphoria #DisneyPlusVoices #fypシ

1.5K Likes, 30 Comments. TikTok video from Austin (@austin.w.s): “It just hits…different #euphoria #DisneyPlusVoices #fypシ”. All For Us – from the HBO Original Series Euphoria – Labrinth & Zendaya.

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All For Us – from the HBO Original Series Euphoria – Labrinth & Zendaya

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Harwant

What happens when you take ibuprofen #CapCut #ibuprofen #science #cellsatwork #BbStyleFearlessly #GetTheWChallenge #learnontiktok #fact #advil

793. 6K Likes, 1.6K Comments. TikTok video from Harwant (@xharwant): “What happens when you take ibuprofen #CapCut #ibuprofen #science #cellsatwork #BbStyleFearlessly #GetTheWChallenge #learnontiktok #fact #advil”. WHAT HAPPENS
WHEN YOU TAKE
IBUPROFENIBUPROFEN Ginseng Strip 2002 – Yung Lean.

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Ginseng Strip 2002 – Yung Lean

    Which one to take when?

    Navigating Healthcare

    by




    Laura Salazar, MD


    Sep
    15,
    2022

    It’s not always easy knowing what to do when you or a loved one isn’t feeling well. While it’s always a good idea to consult your doctor about any over-the-counter (OTC) medications you’re considering taking, many people commonly turn to acetaminophen or ibuprofen for minor aches, pains and fevers.

    But how can you know what to take when? And how much? Here’s your guide to acetaminophen, ibuprofen and the differences between them.

    When to take acetaminophen (aka Tylenol)

    Acetaminophen (Tylenol) is commonly used for:

    • Mild to moderate fever
    • Mild to moderate pain
    • Headache
    • Muscle ache
    • Toothache

    It’s not quite well understood how it works, but it’s thought to act on pathways in our central nervous system to block pain and on the heat regulating part of our brain (the hypothalamus) to reduce fevers.

    Side effects and risks

    The most common concern people have about acetaminophen is its effects on the liver. It’s true that if taken in excess, acetaminophen can cause liver toxicity that can be severe enough to warrant a liver transplant. However, acetaminophen is actually quite safe when taken appropriately. 

    How much to take

    Always follow the dosing recommendations on the label or as prescribed by your doctor. In general, for adults with normal liver function, you can take up to 3 g/day (1000 mg every 8 hours) without any risk to the liver. For those with heavy alcohol use, malnutrition or low body weight, advanced age or liver disease, you can usually take up to 2 g/day without risk of liver damage. Children’s doses are based on their age and size—please consult your pediatrician for more information. 

    The biggest thing to remember is more does not mean better. Taking more than the recommended doses does not mean it will provide more pain relief or reduce the fever more effectively. Higher than recommended doses actually have little to no benefit and come with risks to your health and safety.

    One of the other things to remember with acetaminophen is that it is commonly found in other medications, both over-the-counter (OTC) and prescription. Make sure you read your labels to ensure you’re not overdosing on acetaminophen accidentally. For example, some cold remedies contain acetaminophen. If you’re already taking 3 g/day of acetaminophen and add NyQuil for a cold, you could unintentionally be taking higher than recommended doses of acetaminophen. Similarly, prescription pain medicines like acetaminophen with codeine (Tylenol #3) or hydrocodone with acetaminophen (Norco) need to be used with caution, especially when taken with OTC acetaminophen.

    When to take ibuprofen (aka Advil or Motrin)

    Ibuprofen is an anti-inflammatory medicine used for pain, fever and inflammation. It may be a good option when you’re experiencing things like:

    • Osteoarthritis
    • Sprains and strains
    • Swelling
    • Back pain
    • Gout
    • Menstrual cramps

    Ibuprofen works on enzymes in our body (COX-1 and 2) which are important pathways involved in inflammation, pain and fever. It is classified in a category of medicines called NSAIDs (non-steroidal anti-inflammatory drugs), which includes other medicines that work similarly like naproxen, diclofenac, meloxicam and others.

    Side effects and risks

    Ibuprofen and other NSAIDs can have serious side effects and must be taken with caution. They can increase your risk of heart attack and stroke, serious gastrointestinal bleeding from ulcers or (very rarely) perforation of the stomach and intestines. NSAIDs can also prolong bleeding time, which can lead to significant hemorrhage, especially if someone is already taking a blood thinner. They can also cause kidney diseases like interstitial nephritis, renal papillary necrosis or even just acute kidney injury.

    Because of these potentially serious problems, people who are on blood thinners or living with health problems like heart disease, kidney disease, history of gastrointestinal disease or bleeding disorders should not take NSAIDs at all. Always consult your doctor if you have health problems and are not sure if it would be safe to take ibuprofen.

    Does this mean that everyone should avoid taking ibuprofen and NSAIDs for fear of developing a major health problem? No! When taken appropriately, ibuprofen can be very helpful and the risks can be minimized. For example, a healthy person with a fever should be able to take ibuprofen for 1-2 days without worrying about any risks.

    However, you should always consult your doctor about whether ibuprofen is safe for you and for how long. Those with chronic pain or chronic health conditions like rheumatoid arthritis may require long-term use of anti-inflammatories and may need to be monitored with blood tests to ensure the NSAIDs are not causing any harm.

    How much to take

    Always follow the dosing recommendations on the label or as prescribed by your doctor. The maximum amount of ibuprofen for healthy adults is 800 milligrams per dose or 2400 mg per day (3 maximum doses). A child’s dose is based on the age and weight of the child, so consult your pediatrician about what dose is right for their needs.

    So, what’s the difference between acetaminophen and ibuprofen?

    The biggest difference between acetaminophen and ibuprofen is ibuprofen’s anti-inflammatory effects, which acetaminophen does not have. Therefore, pain that is caused by inflammation responds better to ibuprofen than it would to acetaminophen. 

    Since acetaminophen works on the pain pathway, it still helps with these problems—but it may not work as well as ibuprofen. However, since acetaminophen is usually safer to take than NSAIDs, it is often recommended to try to use acetaminophen first. Oftentimes, if people find acetaminophen to not be as helpful as desired, I recommend taking both ibuprofen and acetaminophen together. If acetaminophen helps even a little, then maybe you won’t need to take as much ibuprofen.

    For problems that might not be related to inflammation (fevers, headaches, etc.), always try acetaminophen first. It can work just as well as, if not better than, ibuprofen.

    If you’re experiencing pain, fever or injury, talk to your doctor about the best pain management options for you. Find a doctor near you or get virtual care from home via MyBSWHealth.

    Ibuprofen Viva Pharm 400 mg No. 20 tab

    Instructions for medical use of the medicinal product (Insert leaflet)

    Trade name
    Ibuprofen Viva Pharm

    International nonproprietary name
    Ibuprofen

    9 0002 Dosage form, dosage
    Coated tablets, 200 mg and 400 mg

    Pharmacotherapeutic group
    Musculoskeletal system. Anti-inflammatory and antirheumatic drugs. Anti-inflammatory and antirheumatic drugs, non-steroidal. propionic acid derivatives. Ibuprofen.
    ATX code M01AE01

    Indications for use
    Relief of pain in the following conditions:
    – headache and toothache
    – migraine
    – painful menstruation
    – neuralgia
    – back pain
    – muscle and rheumatic pain
    – febrile condition with influenza and colds

    Checklist before use
    Contraindications
    – hypersensitivity to the active substance or to any of the components of the drug
    – history of hypersensitivity reactions (in particular, bronchial asthma, rhinitis, angioedema or urticaria), provoked by the use of acetylsalicylic acid or other non-steroidal anti-inflammatory drugs
    – peptic ulcer / bleeding from an ulcer in the acute stage or in history (two or more confirmed episodes
    GI bleeding or perforation induced by NSAID use and a history of severe dehydration
    (due to vomiting, diarrhea or insufficient fluid intake)
    – hemophilia and other bleeding disorders (including hypocoagulation), hemorrhagic diathesis
    – severe liver failure
    – severe renal failure
    – severe heart failure (NYHA class IV – classification of the New York Heart Association)
    – persons with hereditary fructose intolerance, Lapp-lactase deficiency, glucose-galactose malabsorption
    – pregnancy (III trimester) and lactation
    – children and adolescents up to 18 years of age
    Precautions for safe use
    Talk to your doctor or pharmacist before taking Ibuprofen Viva Pharm.
    Interactions with other drugs
    The concomitant use of ibuprofen (and other NSAIDs) with the following drugs should be avoided:
    Acetylsalicylic acid: with the exception of low doses of aspirin (not more than 75 mg per day) prescribed by a doctor, since the simultaneous use of ibuprofen and acetylsalicylic acid may increase the risk of adverse reactions.
    Ibuprofen, when used simultaneously with low doses of acetylsalicylic acid, can competitively inhibit platelet aggregation. Although the admissibility of extrapolating these data to clinical practice remains uncertain, the possible effect of regular long-term ibuprofen use on reducing the cardioprotective effect of low doses of acetylsalicylic acid cannot be ruled out. The effect of episodic use of ibuprofen on the cardioprotective properties of acetylsalicylic acid seems unlikely.
    Other NSAIDs, in particular selective cyclooxygenase-2 inhibitors: the simultaneous use of two or more drugs from the NSAID group should be avoided due to a possible increase in the risk of side effects.
    Use with caution concomitantly with the following drugs:
    Glucocorticosteroids: due to possible increased risk of ulcers or gastrointestinal bleeding.
    Antihypertensives and diuretics: NSAIDs may reduce the effectiveness of drugs in these groups. Simultaneous use with diuretics can lead to increased nephrotoxicity of NSAIDs.
    Anticoagulants: NSAIDs may enhance the effect of anticoagulants, in particular warfarin.
    Antiplatelet agents and selective serotonin reuptake inhibitors (SSRIs): increased risk of gastrointestinal bleeding.
    Cardiac glycosides: the simultaneous administration of NSAIDs and cardiac glycosides can lead to worsening of heart failure, a decrease in glomerular filtration rate and an increase in the concentration of cardiac glycosides in blood plasma.
    Lithium preparations: there is evidence of the likelihood of an increase in the concentration of lithium in the blood plasma against the background of the use of NSAIDs.
    Methotrexate: there is evidence of the likelihood of an increase in the concentration of methotrexate in plasma against the background of the use of NSAIDs.
    Cyclosporine: Increased risk of nephrotoxicity when NSAIDs and cyclosporine are coadministered.
    Mifepristone: NSAIDs should be started no earlier than 8-12 days after taking mifepristone, since NSAIDs may reduce the effectiveness of mifepristone.
    Tacrolimus: Co-administration of NSAIDs and tacrolimus may increase the risk of nephrotoxicity.
    Zidovudine: The simultaneous use of NSAIDs and zidovudine may lead to increased hematological toxicity. There is evidence of an increased risk of hemarthrosis and hematomas in HIV-positive patients with hemophilia receiving concomitant treatment with zidovudine and ibuprofen.
    Quinolone antibiotics: Patients receiving concomitant treatment with NSAIDs and quinolone antibiotics may have an increased risk of seizures.
    Special warnings
    If you have the conditions listed in this section, seek medical advice before using this medicine.
    Undesirable effects can be minimized if the drug is taken for a short period of time, at the minimum effective dose necessary to eliminate symptoms.
    In the elderly, there is an increased incidence of adverse reactions to the use of NSAIDs, especially gastrointestinal bleeding and perforation, in some cases fatal.
    Influence on the respiratory system: in patients with bronchial asthma or an allergic disease in the acute stage, as well as in patients with a history of bronchial asthma / allergic disease, the drug may provoke bronchospasm.
    Concomitant use with other NSAIDs: Concomitant use of ibuprofen with other NSAIDs, in particular selective cyclooxygenase-2 inhibitors, should be avoided.
    Systemic lupus erythematosus and mixed connective tissue disease: The use of the drug in patients with systemic lupus erythematosus or mixed connective tissue disease is associated with an increased risk of developing aseptic meningitis.
    Effects on the kidneys: the drug may cause deterioration of kidney function with the development of renal failure.
    There is a risk of kidney failure in dehydrated children and adolescents.
    Effects on the liver: the drug may cause impaired liver function.
    Influence on the cardiovascular system and cerebral circulation: it is recommended to use the drug with caution in patients with arterial hypertension and / or heart failure (before use, consult a doctor) due to the existing reports of fluid retention, increased blood pressure and the appearance of edema on the background of NSAID use.
    Patients with uncontrolled hypertension, NYHA class II-III congestive heart failure, established coronary artery disease, peripheral arterial disease, and/or cerebrovascular disease should only be treated with ibuprofen after a careful benefit-risk assessment, and high doses of ibuprofen should be avoided (≥ 2400 mg/day).
    Influence on the gastrointestinal tract: it is necessary to use the drug with caution in patients with a history of diseases of the gastrointestinal tract (ulcerative colitis, Crohn’s disease), since the use of drugs in this group may exacerbate these diseases.
    There have been reports of cases of gastrointestinal bleeding, ulcers and perforation at any time of the use of any drugs from the NSAID group, with or without warning symptoms or a previous history of such complications.
    An increased risk of gastrointestinal bleeding or ulcers/perforation is associated with the use of high doses of NSAIDs, the presence of a patient’s history of peptic ulcer, especially complicated by bleeding or perforation, and also with the use of the drug in the elderly. In these categories of patients, treatment should begin with the lowest effective dose of the drug.
    Patients with a history of gastrointestinal toxicity, especially elderly patients, should report any unusual gastrointestinal symptoms (particularly in the case of gastrointestinal bleeding), especially at the start of treatment.
    If gastrointestinal bleeding or ulcers occur in patients receiving ibuprofen treatment, the drug should be discontinued.
    Medicinal products that inhibit cyclooxygenase/prostaglandin synthesis may cause reproductive harm in women by interfering with ovulation. This effect is reversible upon discontinuation of the drug.
    Severe skin reactions
    Serious skin reactions, some of which have been fatal, including exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis, have rarely been reported in association with the use of NSAIDs. Patients are at greatest risk of these reactions in the early stages of therapy, occurring in most cases within the first month of treatment.
    Acute generalized exanthematous pustulosis (AGEP) has been reported with ibuprofen-containing products. Ibuprofen should be discontinued at the first appearance of signs and symptoms of serious skin reactions such as skin rash, mucosal lesions, or any other sign of hypersensitivity.
    The preparation contains Ponceau 4R (E124), FD&C yellow No. 6 (E110) which may cause allergic reactions. FD&C Yellow No. 6 (E110) is prohibited for use in children.
    During pregnancy or lactation
    Inhibition of prostaglandin synthesis may indirectly affect pregnancy, embryonic and fetal development. The risk of spontaneous abortion, heart defects and gastroschisis is increased with the use of prostaglandin synthesis inhibitors in early pregnancy.
    The absolute risk of cardiovascular abnormalities increased from less than 1% to approximately 1.5%.
    This risk increases with increasing dosage and duration of therapy.
    In this regard, the use of the drug in the I-II trimesters of pregnancy should be avoided, if necessary, the drug should be taken with a doctor.
    When taking ibuprofen by women planning a pregnancy, or in the I-II trimesters of pregnancy, the dosage and duration of treatment should be minimal.
    The use of prostaglandin inhibitors in the third trimester of pregnancy contributes to the development of the fetus and mother:
    • cardiopulmonary insufficiency with premature closure of the ductus arteriosus and development of pulmonary hypertension;
    • kidney failure, which can lead to complete cessation of kidney function with the development of oligohydramnios (dehydration).
    At the end of pregnancy in mother and child:
    • increased bleeding time, antiplatelet effect even at very low doses;
    • suppression of uterine contractions and delayed or prolonged labor.
    Therefore, ibuprofen is contraindicated in the third trimester of pregnancy.
    Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms
    Given the possible side effects, care must be taken when driving a vehicle or potentially dangerous mechanisms.

    Directions for use
    For oral use. For short term use only. Read the instructions carefully before taking the drug.
    For adults, the drug is prescribed 1 tablet (200 mg) up to 3 times a day. To achieve a faster therapeutic effect, the dose can be increased to 400 mg (2 tablets of 200 mg or 1 tablet of 400 mg) up to 3 times a day. The tablets should be taken with water.
    The interval between taking the tablets should be at least 4 hours.
    Maximum daily dose: 1200 mg (6 tablets of 200 mg or 3 tablets of 400 mg).
    If the symptoms persist or worsen after taking the drug for 2-3 days, stop treatment and consult a doctor. If you need to take the drug for more than 10 days, you should consult a doctor.
    To reduce the risk of side effects, it is recommended to take the drug for the shortest possible course and at the lowest effective dose necessary to eliminate symptoms.
    Precautions to be taken in case of overdose
    In children, overdose symptoms may occur after taking doses exceeding 400 mg/kg body weight. In adults, the dose-dependent effect is less pronounced. The half-life of the drug in case of overdose is 1.5 – 3 hours.
    Symptoms: In most patients who have used clinically significant doses of NSAIDs, overdose symptoms are limited to nausea, vomiting, epigastric pain, or, less commonly, diarrhea. Symptoms such as tinnitus, headache, and gastrointestinal bleeding may occur. In more severe cases, manifestations of toxicity from the central nervous system are observed, in particular, drowsiness, occasionally agitation, as well as disorientation or coma, in rare cases, convulsions occur. In cases of severe poisoning, metabolic acidosis and an increase in prothrombin time may develop, which is probably due to the interaction of the drug and circulating blood coagulation factors. Acute kidney failure and liver damage may occur. In patients with bronchial asthma, an exacerbation of this disease is possible.
    Treatment: symptomatic and supportive, with the obligatory provision of free airway patency, monitoring of cardiac activity and vital signs until the patient’s condition returns to normal. Recommended oral administration of activated charcoal within one hour after taking a potentially toxic dose of the drug. Frequent or prolonged seizures should be treated with intravenous diazepam or lorazepam. In bronchial asthma, the use of bronchodilators is recommended.
    Recommendations for seeking advice from a healthcare professional
    to clarify how to use a medicinal product
    If you are not sure how to use a medicinal product, we recommend that you seek advice from a healthcare professional.

    Description of adverse reactions that occur with the standard use of drugs and measures to be taken in this case
    Side effects are predominantly dose-dependent.
    The following adverse reactions have been reported with short-term use of ibuprofen at doses not exceeding 1200 mg/day.
    There may be a relationship between taking ibuprofen at doses ≥ 2400 mg per day and a slight increased risk of developing arterial thrombotic events (eg, myocardial infarction and stroke).
    The observed adverse reactions are most often of a gastrointestinal nature. Adverse reactions mainly depend on the dose, in particular, the risk of gastrointestinal bleeding depends on the dose and duration of treatment.
    In the treatment of chronic conditions and with long-term use, other adverse reactions may occur.
    Determination of the frequency of side effects is carried out in accordance with the following criteria: very often (≥1/10), often (≥1/100 to <1/10), infrequently (≥1/1000 to <1/100), rarely (≥ 1/10000 to <1/1000), very rare (<1/10000), unknown (cannot be estimated from the available data)
    Uncommon
    Hypersensitivity reactions: non-specific allergic reactions and anaphylactic reactions, respiratory tract reactions , including its exacerbation, bronchospasm, shortness of breath, dyspnea), skin reactions (itching, urticaria, purpura, Quincke’s edema) and rarely exfoliative and bullous dermatoses (including epidermal necrolysis and erythema multiforme)
    Various types of skin rash
    Abdominal pain, nausea, dyspepsia
    Headache
    Rarely
    Diarrhea, flatulence, constipation and vomiting
    Very rare
    Hematopoietic disorders: anemia singing, thrombocytopenia, pancytopenia, agranulocytosis. The first signs are fever, sore throat, mouth ulcers, flu-like symptoms, severe loss of energy, unexplained bleeding and bruising
    – severe hypersensitivity reactions, including swelling of the face, tongue and throat, shortness of breath, Quincke or severe anaphylactic shock)
    – gastric ulcer (peptic ulcer) and duodenal ulcer, perforation or gastrointestinal bleeding, melena, hematemesis, in some cases fatal, more often in elderly patients
    – ulcerative stomatitis, gastritis
    – acute renal failure, papillonecrosis, especially with prolonged use, in combination with an increase in the level of urea in the blood serum and the appearance of edema
     liver dysfunction
     complicated skin diseases: exfoliative and bullous dermatoses, including toxic epidermal necrolysis (Lyell’s syndrome), Stevens-Johnson syndrome, multiforme erythema
    – in patients with autoimmune disorders (systemic lupus erythematosus, mixed connective tissue disease) during treatment with ibuprofen, isolated cases of symptoms of aseptic meningitis were observed, in particular, neck stiffness, headache, nausea, vomiting, fever or disorientation
    Unknown
    – reactions from the respiratory tract (bronchial asthma, including its exacerbation, bronchospasm, shortness of breath, dyspnea)
    – heart failure and edema
    – Hypertension
    – Exacerbation of non-specific ulcerative colitis and Crohn’s disease
    – Renal failure
    – Acute generalized exanthematous pustulosis (AGEP)
    – Drug reaction with eosinophilia and systemic symptoms (DRESS syndrome)

    9000 2 If adverse drug reactions occur, contact a healthcare professional , a pharmaceutical worker or directly to the information database on adverse reactions (actions) to drugs, including reports of drug failure
    RSE on REM “National Center for Expertise of Medicines and Medical Devices” Committee for Quality Control and Safety of Goods and Services of the Ministry of Health of the Republic of Kazakhstan
    http://www. ndda.kz

    Additional information
    Composition of the drug
    One tablet contains
    active substance – ibuprofen 200 mg or 400 mg,
    excipients: lactose monohydrate, corn starch, microcrystalline cellulose (101 and 102), croscarmellose sodium, povidone, magnesium stearate, anhydrous colloidal silicon dioxide;
    shell composition: Opadry® II 85F24336 PINK (polyvinyl alcohol, titanium dioxide (E171), polyethylene glycol / macrogol, talc, Ponceau 4R (E124), FD&C yellow No. 6 (E110).
    Description of appearance, odor, taste
    Tablets, round

    Form and packaging
    7 tablets (for a dosage of 200 mg) or 10 tablets (for a dosage of 400 mg) are placed in a blister pack made of PVC film and aluminum foil.0005 2 blister packs, together with instructions for medical use in the state and Russian languages, are put into a pack of cardboard.

    Shelf life
    3 years.
    Do not use after the expiration date!
    Storage conditions
    Store in a dry place, at a temperature not exceeding 25°C.
    Keep out of the reach of children!

    Terms of dispensing from pharmacies
    Without a prescription

    Information about the manufacturer
    VIVA PHARM LLP, Republic of Kazakhstan
    Almaty, st. Degdar, 33
    Tel.: +7 (727) 383 74 63, fax: +7 (727) 383 74 56
    E-mail: [email protected]

    Registration certificate holder
    VIVA PHARM LLP, Republic of Kazakhstan
    Almaty, st. Degdar, 33
    Tel.: +7 (727) 383 74 63, fax: +7 (727) 383 74 56
    E-mail: [email protected]

    Name, address and contact details (phone, fax, e-mail ) an organization on the territory of the Republic of Kazakhstan that accepts claims (proposals) on the quality of medicines from consumers and is responsible for post-registration monitoring of the safety of medicines
    VIVA PHARM LLP, Republic of Kazakhstan
    050030, Almaty, st. Degdar, 33
    Tel.: +7 (727) 383 74 63, fax: +7 (727) 383 74 56
    E-mail: [email protected]

    Ibuprofen tablets | Borimed

    * In other regions, the graphic design of the packaging may differ depending on the country of registration.

    Registration countries:

    • Belarus;
    • Armenia;
    • Georgia;
    • Kyrgyzstan;
    • Moldova;
    • Russian Federation;
    • Tajikistan;
    • Turkmenistan;
    • Uzbekistan;

    INN:

    Ibuprofen

    Dosage form:

    Tablets

    Dosage:

    200 mg

    Packaging:

    50 tablets

    Pharmacotherapeutic group, ATX:

    M01. Anti-inflammatory and antirheumatic agents

    ATC code:

    M01AE01

    Trade name:

    Ibuprofen

    Release form:

    Tablets

    Description:

    film-coated tablets, white, with a biconvex surface.

    Composition:

    each tablet contains: active ingredient: ibuprofen – 200 mg; excipients: potato starch, magnesium stearate, calcium stearate, povidone, opadry ΙΙ (contains polyvinyl alcohol, partially hydrolyzed, talc, macrogol 3350, lecithin, titanium dioxide (E 171)).

    Indications for use

    Ibuprofen is used as an analgesic and anti-inflammatory agent in the treatment of rheumatoid arthritis (including juvenile rheumatoid arthritis or Still’s disease), ankylosing spondylitis, osteoarthritis, and other non-rheumatoid (seronegative) arthropathies. Ibuprofen is indicated for the treatment of non-rheumatic inflammatory conditions of the periarticular tissues such as frozen shoulder (inflammation of the lining of the joint), bursitis, tendinitis, tendovaginitis and back pain. Ibuprofen can also be used to relieve pain from soft tissue injuries such as sprains. Ibuprofen is also indicated as an analgesic for mild to moderate pain in conditions such as dysmenorrhea, dental or postoperative pain, and for the symptomatic relief of headaches, including migraines.

    Contraindications

    Ibuprofen is contraindicated in patients with hypersensitivity to the active or excipients of the drug.

    Ibuprofen should not be used in patients who have previously experienced hypersensitivity reactions (eg, asthma, urticaria, angioedema, or rhinitis) after taking ibuprofen, aspirin, or other NSAIDs.
    Ibuprofen is also contraindicated in patients with a history of gastrointestinal bleeding or perforation associated with previous ibuprofen therapy. Ibuprofen should not be used in patients with recurrent peptic ulcer or gastrointestinal bleeding (two or more episodes of proven ulceration or bleeding). Ibuprofen should not be administered to patients with conditions associated with an increased bleeding tendency.

    Ibuprofen is contraindicated in patients with severe heart, hepatic or renal impairment.

    Ibuprofen is contraindicated during the last trimester of pregnancy.

    Dosage and administration

    For oral administration. It is advisable to use during or after a meal with water. Tablets should be swallowed whole, not chewed, broken or crushed to avoid discomfort and irritation of the throat.
    Side effects can be minimized by using the lowest effective dose for a short time.

    Adults: The recommended dosage of ibuprofen is 1200-1800 mg daily in divided doses. Some patients may take 600-1200 mg of ibuprofen per day. In severe or acute conditions, the dosage can be increased, provided that the total daily dose does not exceed 2400 mg, in divided doses.

    Children: The daily dose of ibuprofen is 20 mg/kg of body weight in divided doses. In juvenile rheumatoid arthritis, the dose may be increased to 40 mg/kg body weight in divided doses.
    Not recommended for children weighing less than 7 kg.

    Elderly: older people are at increased risk of side effects. If it is necessary to use non-steroidal anti-inflammatory drugs (NSAIDs), ibuprofen should be used at a low effective dose for a short time.