What are the potential side effects of taking ibuprofen 600mg. How long does ibuprofen stay in your system. Is ibuprofen 600mg considered high risk. How much ibuprofen can you safely take without risking kidney damage.

Understanding Ibuprofen 600mg: Uses and Dosage

Ibuprofen 600mg is a widely used nonsteroidal anti-inflammatory drug (NSAID) that serves multiple purposes in pain management and inflammation reduction. Healthcare providers often prescribe this medication to address various conditions, including:

• Moderate to severe pain
• Inflammation
• Fever
• Menstrual cramps
• Rheumatic pain
• Headaches

The typical dosage for adults is one 600mg tablet every 4 to 6 hours, with a maximum of four doses in a 24-hour period. It’s crucial to adhere to the recommended dosage to minimize the risk of side effects and potential complications.

Duration of Effect and Presence in the System

How long does ibuprofen 600mg remain effective in the body? The pain-relieving and anti-inflammatory effects of ibuprofen 600mg generally last for 4 to 6 hours, though in some cases, it may provide relief for up to 8 hours. However, the presence of the drug in your system can extend beyond its active effects.

Ibuprofen has a relatively short half-life of about 2 hours, meaning that half of the drug is eliminated from the body within this timeframe. Despite this, traces of ibuprofen can be detected in your system for up to 24 hours after ingestion, especially if you’ve been taking it regularly or in higher doses.

Common Side Effects of Ibuprofen 600mg

While ibuprofen 600mg is generally considered safe when used as directed, it can cause a range of side effects. It’s important to be aware of these potential reactions to ensure prompt recognition and appropriate action if they occur.

Gastrointestinal Side Effects

The most frequently reported side effects of ibuprofen 600mg involve the gastrointestinal system. These may include:

• Nausea
• Stomach pain
• Heartburn
• Diarrhea
• Indigestion

These symptoms often occur due to ibuprofen’s ability to irritate the stomach lining. Taking the medication with food or milk can help alleviate some of these effects.

Other Common Side Effects

Beyond gastrointestinal issues, ibuprofen 600mg may cause:

• Headache
• Dizziness
• Drowsiness
• Mild rash
• Tinnitus (ringing in the ears)

These side effects are typically mild and often resolve on their own. However, if they persist or worsen, it’s advisable to consult a healthcare professional.

Potential Serious Side Effects and Risks

While less common, ibuprofen 600mg can occasionally cause more severe side effects that require immediate medical attention. These include:

• Difficulty breathing or shortness of breath
• Chest pain
• Swelling of the face, throat, or tongue
• Severe stomach pain
• Black or bloody stools
• Vision changes
• Signs of kidney problems (e.g., changes in urine output)

Is ibuprofen 600mg considered high risk? While not inherently high-risk when used as directed, ibuprofen 600mg can pose significant dangers if misused or taken by individuals with certain health conditions. The risk increases with long-term use, higher doses, or in people with pre-existing cardiovascular or gastrointestinal issues.

Long-term Risks of Ibuprofen Use

Prolonged use of ibuprofen 600mg may lead to various health complications, including:

1. Increased risk of stomach ulcers and gastrointestinal bleeding
2. Kidney problems
3. Elevated risk of cardiovascular events (e.g., heart attack, stroke)
4. Hypertension (high blood pressure)
5. Increased risk of heart failure

These risks underscore the importance of using ibuprofen 600mg only as directed and for the shortest duration necessary to achieve symptom relief.

Ibuprofen and Kidney Health: Finding the Right Balance

One of the primary concerns associated with ibuprofen use is its potential impact on kidney function. How much ibuprofen can you safely take without risking kidney damage? The answer depends on various factors, including your overall health, age, and existing kidney function.

For adults, the maximum recommended dose of ibuprofen is 800 milligrams per dose or 3200 mg per day (equivalent to four maximum doses). Exceeding these limits significantly increases the risk of kidney damage, especially with prolonged use.

Protecting Your Kidneys While Using Ibuprofen

To minimize the risk of kidney-related complications when using ibuprofen 600mg, consider the following guidelines:

• Stay within the recommended dosage limits
• Use the lowest effective dose for the shortest possible duration
• Stay well-hydrated while taking ibuprofen
• Avoid combining ibuprofen with other NSAIDs or nephrotoxic medications
• Consult your healthcare provider if you have pre-existing kidney issues or are at higher risk for kidney problems

By following these precautions, you can help protect your kidneys while still benefiting from the pain-relieving properties of ibuprofen.

Interactions with Other Substances: The CBD Oil Conundrum

As the popularity of CBD oil grows, many people wonder about its potential interactions with common medications like ibuprofen. Is it safe to take ibuprofen 600mg if you’re already using CBD oil?

Generally, it’s advisable to exercise caution when combining ibuprofen 600mg with CBD oil. Both substances can affect liver enzymes responsible for metabolizing drugs, potentially leading to increased concentrations of ibuprofen in the bloodstream. This interaction may elevate the risk of side effects such as:

• Gastrointestinal discomfort
• Dizziness
• Drowsiness
• Increased bleeding risk

Furthermore, both ibuprofen and CBD oil can have blood-thinning effects, which may compound the risk of bleeding when used together. It’s crucial to consult with a healthcare provider before combining these substances to ensure safe and effective use.

Natural Alternatives to Ibuprofen 600mg

For those seeking alternatives to ibuprofen 600mg, several natural options may offer pain relief and anti-inflammatory benefits with potentially fewer side effects. Some popular natural alternatives include:

1. Turmeric: Contains curcumin, a powerful anti-inflammatory compound
2. Ginger: Offers natural pain-relieving and anti-inflammatory properties
3. White willow bark: Contains salicin, a precursor to aspirin
4. Capsaicin: Derived from chili peppers, it can help alleviate pain
5. Omega-3 fatty acids: Found in fish oil, they have anti-inflammatory effects
6. Boswellia: An herb with potent anti-inflammatory properties
7. Bromelain: An enzyme found in pineapple with anti-inflammatory effects

While these natural alternatives may be gentler on the stomach and have fewer side effects than ibuprofen, it’s important to note that they can still interact with other medications and may not be suitable for everyone. Always consult with a healthcare provider before incorporating new supplements or natural remedies into your regimen.

Managing Side Effects and Knowing When to Seek Help

If you experience unexpected side effects while taking ibuprofen 600mg, it’s crucial to know how to respond appropriately. In most cases of mild side effects, the following strategies may help:

• Take the medication with food to reduce stomach irritation
• Stay well-hydrated to help flush the medication from your system
• Use the lowest effective dose for the shortest duration possible
• Consider alternative pain management techniques, such as heat or cold therapy

However, if you experience severe or persistent side effects, it’s important to stop taking the medication and seek medical advice promptly. This is particularly crucial if you develop signs of an allergic reaction, gastrointestinal bleeding, or cardiovascular issues.

Red Flags: When to Contact Your Healthcare Provider

Be sure to reach out to your doctor immediately if you experience any of the following while taking ibuprofen 600mg:

• Severe abdominal pain or persistent stomach discomfort
• Blood in vomit or stools
• Unexplained bruising or bleeding
• Swelling of the face, lips, tongue, or throat
• Difficulty breathing or wheezing
• Chest pain or irregular heartbeat
• Sudden weight gain or swelling in the extremities
• Yellowing of the skin or eyes (jaundice)
• Unusual fatigue or weakness
• Changes in urination patterns

These symptoms could indicate serious adverse reactions that require immediate medical attention. Your healthcare provider can assess your condition and determine whether it’s safe for you to continue using ibuprofen or if an alternative treatment is necessary.

Responsible Use of Ibuprofen 600mg: Best Practices

To maximize the benefits of ibuprofen 600mg while minimizing potential risks, consider adopting these best practices:

1. Always follow the recommended dosage and frequency of use
2. Take ibuprofen with food or milk to reduce stomach irritation
3. Avoid alcohol consumption while using ibuprofen
4. Do not combine ibuprofen with other NSAIDs unless directed by a healthcare provider
5. Inform your doctor about all medications and supplements you’re taking
6. Use ibuprofen for the shortest duration necessary to achieve symptom relief
7. Consider alternative pain management techniques when appropriate
8. Stay vigilant for any unusual side effects or changes in your health

By adhering to these guidelines, you can help ensure the safe and effective use of ibuprofen 600mg while minimizing the risk of adverse effects.

Special Considerations for At-Risk Groups

Certain individuals may be at higher risk for complications from ibuprofen use. These groups include:

• Older adults
• People with a history of gastrointestinal issues
• Individuals with cardiovascular disease
• Those with kidney or liver problems
• Pregnant women, especially in the third trimester
• People taking blood thinners or certain other medications

If you fall into any of these categories, it’s crucial to consult with your healthcare provider before using ibuprofen 600mg. They can help assess the potential risks and benefits, and may recommend alternative pain management strategies or lower doses if appropriate.

Common Side Effects of Ibuprofen 600mg

Ibuprofen 600mg is a commonly used over the counter medication for pain relief. While it is generally safe to use, it can have some side effects that may be uncomfortable or concerning. In this article, we will discuss the common side effects of ibuprofen 600mg and provide tips on how to manage them. We will also explain when to seek medical attention if the side effects become severe.

What are the potential side effects of taking ibuprofen 600?

The most common side effects of taking ibuprofen 600 are gastrointestinal disturbances, such as nausea, stomach pain, heartburn, and diarrhea. Other potential side effects include increased risk of bleeding, kidney damage, headache, dizziness, and rash. Severe side effects can include difficulty breathing, swelling of the face, throat and tongue, chest pain, and changes in vision.

Is it safe to take ibuprofen 600 if I’m already taking CBD oil?

It is generally recommended to avoid taking ibuprofen 600 if you are already taking CBD oil, as this combination can increase the risk of side effects such as stomach upset, dizziness, and drowsiness. It is important to consult your doctor before taking any new medications.

What should I do if I experience any unexpected side effects from taking ibuprofen 600?

If you experience any unexpected side effects from taking ibuprofen 600, you should stop taking the medication immediately and consult your doctor. Make sure to report all side effects to your doctor, even if they are mild and not serious. Your doctor will be able to advise you on the best course of action for your particular situation.

Are there any long-term risks associated with taking ibuprofen 600?

Yes, there are long-term risks associated with taking ibuprofen 600. These include an increased risk of stomach ulcers and bleeding, kidney problems, and an increased risk of cardiovascular disease. Taking ibuprofen also increases the risk of low blood pressure and heart failure. It is important to talk to your doctor before taking ibuprofen 600 or any other medication.

Are there any natural alternatives to ibuprofen 600 that may be less likely to cause side effects?

Yes, there are natural alternatives to ibuprofen 600 that may be less likely to cause side effects. These include turmeric, ginger, white willow bark, and capsaicin. All of these have anti-inflammatory properties, but are gentler on the stomach than ibuprofen. However, it is important to consult a doctor before taking any of these natural alternatives, as they may interact with other medications.

How long does ibuprofen stay in your system?

Ibuprofen 600 can stay in your system for up to 24 hours. However, it is recommended to take ibuprofen no more than every four to six hours, and not to exceed more than four doses in 24 hours. Some of the side effects of taking ibuprofen 600 can include dizziness, headache, drowsiness, nausea, and vomiting.

How much ibuprofen can I take without hurting kidneys?

Ibuprofen is generally safe for short-term use at recommended doses. The maximum dose of ibuprofen for adults is 800 milligrams per dose or 3200 mg per day (4 maximum doses). Taking more than the recommended dose of ibuprofen can lead to an increased risk of kidney damage. Therefore, it is best to stay within the recommended dose to help avoid any potential kidney damage.

How long does 600 mg ibuprofen stay in your system?

Ibuprofen 600 mg typically stays in your system for up to four hours. However, if you take ibuprofen frequently or in high doses, it can remain in your system for up to 24 hours. Common side effects of ibuprofen 600 mg include nausea, heartburn, and stomach pain.

Why is ibuprofen 600 prescribed?

Ibuprofen 600 is typically prescribed to treat pain, inflammation, and fever. It is also used to reduce the severity of menstrual cramps, rheumatic pain, and headaches. Common side effects of ibuprofen 600 include nausea, stomach pain, and heartburn.

Is ibuprofen high risk?

Ibuprofen 600 mg is generally considered to be a safe and effective medication, however, there are potential side effects that can occur. Some of the more common side effects include nausea, dizziness, abdominal pain, and headaches. Rare side effects can include allergic reactions, liver damage, and gastrointestinal bleeding. Therefore, while ibuprofen 600 mg is not considered to be high risk, it is important to be aware of the potential side effects that can occur.

Is ibuprofen 600 mg a painkiller?

Yes, ibuprofen 600 mg is a painkiller, but it can also have side effects. Common side effects include upset stomach, nausea, heartburn, headaches, dizziness, and rashes. If you experience any of these symptoms, contact your doctor right away.

How many hours does ibuprofen 600 last?

Ibuprofen 600 typically lasts for up to four to six hours. However, it can last for up to eight hours for some people. It is important to follow the instructions on the label to ensure that you do not take too much. Side effects can include nausea, vomiting, stomach pain, and headaches.

Should I take ibuprofen 800 or 600 mg?

It is important to note that ibuprofen 600 mg can cause side effects such as stomach pain, nausea, heartburn, headache, dizziness, and drowsiness. If you experience any of these side effects, it is best to consult with your doctor before taking ibuprofen 800 mg.

Can ibuprofen affect urine flow?

Yes, ibuprofen can affect urine flow. Ibuprofen 600mg is a nonsteroidal anti-inflammatory drug (NSAID) that can cause side effects in some people. These can include increased frequency of urination, difficulty in urinating, and increased risk of urinary tract infections.

Does ibuprofen 600 make you sleepy?

No, ibuprofen 600 does not usually make you sleepy. Common side effects of ibuprofen 600 may include nausea, stomach pain, heartburn, constipation, gas, dizziness, headache, and drowsiness. However, drowsiness is not a common side effect of ibuprofen 600 and is not likely to make you sleepy.

Can ibuprofen affect blood pressure?

Yes, ibuprofen can affect blood pressure. Ibuprofen 600 is a nonsteroidal anti-inflammatory drug (NSAID) and can cause an increase in blood pressure. Other side effects of ibuprofen 600 may include upset stomach, stomach pain, indigestion, nausea, and diarrhea.

Does ibuprofen make you tired or sleepy?

Ibuprofen 600 is generally considered to be safe for most people, however it can cause some side effects such as dizziness, drowsiness, and fatigue. It is possible that taking ibuprofen 600 can make you sleepy or tired, however this is not a common side effect. If you experience any of these side effects while taking ibuprofen 600, you should speak to your doctor.

Can I take 2 ibuprofen 600 mg?

Yes, you can take two ibuprofen 600 mg, but you should always consult your doctor or pharmacist before taking any medication. Ibuprofen 600 mg can cause side effects such as nausea, vomiting, stomach pain, blurred vision, headache, rash, drowsiness, and dizziness. Taking more than the recommended dose may cause more severe side effects, so it is important to follow your doctor’s instructions carefully.

Can I take ibuprofen every day for arthritis?

Ibuprofen 600 mg is a strong dose and can cause side effects such as stomach upset, nausea, dizziness, and headaches. It is important to consult with your doctor before taking ibuprofen 600 mg every day for arthritis, as they may recommend a lower dose. Additionally, long-term use of ibuprofen 600 mg can increase your risk of developing serious health problems, such as high blood pressure, heart attack, stroke, and kidney damage.

How often can I take 600 mg of ibuprofen?

It is generally recommended that you not take more than 600 mg of ibuprofen in a single dose, or more than 1200 mg in a 24-hour period. Taking too much ibuprofen can cause side effects such as stomach pain, nausea, vomiting, and headache. If you experience any of these side effects, it is important to contact your doctor right away.

Can I take 2 ibuprofen 600 mg at once?

It is not recommended to take two ibuprofen 600mg at once as it could increase your risk of serious side effects such as stomach bleeding and ulcers. Instead, it is recommended to take ibuprofen 600mg at the lowest effective dose for the shortest amount of time necessary to relieve symptoms. Talk to your doctor or pharmacist if you have any questions.

Can you drive after taking 600 mg ibuprofen?

It is not advisable to drive after taking 600 mg of ibuprofen, as it can cause side effects, such as dizziness and drowsiness. These side effects can impair your ability to drive safely. Additionally, ibuprofen can interfere with your attention and reaction time, potentially putting yourself and others in danger. Therefore, it is best to wait at least 24 hours after taking ibuprofen before driving.

What organs can ibuprofen affect?

Ibuprofen 600 side effects can affect a range of organs, including the stomach, intestines, heart, and kidneys. Gastrointestinal problems such as nausea, vomiting, and stomach pain can occur, as well as heartburn and indigestion. Ibuprofen can also cause an increased risk of heart attack and stroke. Additionally, the drug can affect the kidney, causing swelling, high blood pressure, and increased risk of kidney failure.

How long does it take for ibuprofen 600 to kick in?

Ibuprofen 600 usually starts to work within 30 minutes to provide pain relief. However, it may take up to 1 hour to reach peak effectiveness. It is important to take ibuprofen 600 exactly as directed by a healthcare professional to ensure the best results.

Is ibuprofen 600 too much?

It is not recommended to take more than 600mg of ibuprofen at once, or more than 3200mg per day. Taking too much ibuprofen can cause stomach irritation, nausea, vomiting, and even heartburn. It can also increase the risk of stomach ulcers, kidney and liver damage, and even stroke. Therefore, it is best to consult with a doctor before taking ibuprofen 600, or any other amount.

Drug – Ibuprofen (600 mg) 600mg – Tablet (Ibuprofen) Price List or Cost of Medication

Price Updated on August 8, 2019

Substitute/Alternative Medication to Ibuprofen (600 mg)

  Bar,
,
  Ibulite,
,
  Ibuprofen-200,
,
  Tricofen (600 mg),
,
Alfam,
,
Bren,
,
Bren,
,
Bren (100 mg),
,
Bren (200 mg),
,
Brufen,
,

Drug information on Ibuprofen (600 mg) from Wings Pharmaceuticals Pvt.

Ltd.

⇨ Adenomyosis

⇨ Airplane Ear

⇨ Ankylosing Spondylitis

⇨ Arm pain

⇨ Back Injuries

⇨ Back Pain

⇨ Bird Flu

⇨ Broken or Bruised Ribs

⇨ Cancer Pain

⇨ Cervical Spondylosis

⇨ Chiari Malformations

⇨ Chondromalacia Patella

PO- The recommended dose range is 200 to 600mg 4-6 hourly. Max: 1.2 g/day.

Gastrointestinal : Nausea, epigastric pain, heartburn, diarrhea, abdominal distress, vomiting, blood in stools, indigestion, constipation, abdominal cramps or pain and fullness of GI tract (bloating and flatulence).

Central Nervous System : Dizziness, headache and nervousness.

Skin : Rash and itching.

ENT : Ringing in the ear.

Blood : Bleeding.

Metabolic : Decreased appetite.

Heart : Edema and fluid retention.

Allergic Reactions : Angioedema.

It comes as a capsule and tablet to take by mouth, with or without food.

Contraindicated in patients who have experienced asthma, hives, or allergic-type reactions after taking aspirin or other NSAIDs.

Caution should be exercised in patients with high blood pressure, blood disorders, bleeding problem, heart disease, blood vessel disease, asthma, nose polyps, kidney or liver disease, diabetes, dehydration, alcohol abuse, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding.

It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.

It may cause stomach bleeding or ulcer; if it so consult with your doctor.

Avoid alcohol consumption.

Avoid excess dosage.

Store it at controlled room temperature (20� to 25�C), and in an airtight container.

Schedule : H  Prescription drugs – Drugs to be sold only under the prescription of a Registered Medical Practitioner.

Ibuprofen: Learn More About The Commonly Used Pain Killer Drug

Ibuprofen (600 mg)(Ibuprofen) : Frequently Asked Questions

Q: Can Ibuprofen (600 mg) cause dizziness?

A: Yes, Ibuprofen (600 mg) can cause dizziness in some patients. If you feel dizzy, do not drive or operate any machinery(1^✔ ✔Trusted Source
Ibuprofen

Go to source).

Q: Does Ibuprofen (600 mg) treat osteoarthritis?

A: Ibuprofen (600 mg) relieves osteoarthritis and rheumatoid arthritis symptoms such as inflammation, swelling, stiffness, and joint pain(2^✔ ✔Trusted Source
Ibuprofen

Go to source).

Q: When is the best time to take Ibuprofen (600 mg)?

A: Ibuprofen (600 mg) is usually taken three or four times a day, every 4 to 6 hours. Ibuprofen (600 mg) should be given to children and infants every 6 to 8 hours as needed for pain or fever, but not more than 4 doses in 24 hours(2^✔ ✔Trusted Source
Ibuprofen

Go to source).

Q: Does Ibuprofen (600 mg) help with menstrual pain?

A: Ibuprofen (600 mg) can help relieve severe period pain by inhibiting prostaglandin production(3^✔ ✔Trusted Source
Period pains: Can anti-inflammatory drugs help?

Go to source).

Q: Does Ibuprofen (600 mg) increase the risk of bleeding?

A: The most common complication of Ibuprofen (600 mg) is gastrointestinal bleeding, which can lead to gastritis, ulceration, hemorrhage, or perforation(4^✔ ✔Trusted Source
Ibuprofen

Go to source).

i Sources

Medindia adheres to strict ethical publishing standards to provide accurate, relevant, and current health content. We source our material from reputable places such as peer-reviewed journals, academic institutions, research bodies, medical associations, and occasionally, non-profit organizations. We welcome and value audience feedback as a part of our commitment to health literacy and informed decision-making.

• 1. Ibuprofen – (https://www.healthdirect.gov.au/ibuprofen )
• 2. Ibuprofen – (https://medlineplus.gov/druginfo/meds/a682159.html )
• 3. Period pains: Can anti-inflammatory drugs help? – (https://www.ncbi.nlm.nih. gov/books/NBK279323/ )
• 4. Ibuprofen – (https://www.ncbi.nlm.nih.gov/books/NBK542299/)

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Ibuprofen Lannacher – instructions for use, doses, side effects, reviews of the drug:

Description of the drug Ibuprofen Lannacher (coated tablets, 400 mg) based on official instructions, approved by the manufacturer in 1999

Date of approval : 31.07.1999

Contents

• Active substance
• ATX
• Pharmacological group
• Nosological classification (ICD-10)
• Composition and form of release
• pharmachologic effect
• pharmachologic effect
• Indications
• Contraindications
• Dosage and administration
• Side effects
• Storage conditions
• Best before date
• Reviews

Active ingredient

Ibuprofen* (Ibuprofen*)

ATX

M01AE01 Ibuprofen

Pharmacological group

NSAIDs – Derivatives of propionic acid

Nosological classification (ICD-10)

ICD-10 code list

• G54. 1 Lesions of the lumbosacral plexus
• J06 Acute infections of the upper respiratory tract, multiple and unspecified
• J11 Influenza, virus not identified
• K13.7 Other and unspecified lesions of oral mucosa
• M00-M25 Arthropathy
• M05 Seropositive rheumatoid arthritis
• M10 Gout
• M15-M19 Arthrosis
• M45 Ankylosing spondylitis
• M71 Other bursopathies
• M77. 9Enthesopathy, unspecified
• M79.1 Myalgia
• M79.2 Neuralgia and neuritis, unspecified
• N94.6 Dysmenorrhea, unspecified
• R50 Fever of unknown origin
• R51 Headache
• R52. 2 Other persistent pain
• T08-T14 Injury of unspecified part of trunk, limb or body region
• Z100* CLASS XXII Surgical practice

Composition and formulation

1 coated tablet contains ibuprofen 400 or 600 mg; in a blister 10 pcs., in a box of 3 blisters.

Pharmacological action

Pharmacological action –

anti-inflammatory , analgesic , antipyretic .

It inhibits the synthesis of PG, which prevents the development of inflammatory phenomena (edema, pain, local hyperthermia and hyperemia, etc. ).

It inhibits the synthesis of PG, which prevents the development of inflammatory phenomena (edema, pain, local hyperthermia and hyperemia, etc.).

Indications

Rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gouty arthritis, psoriatic arthritis; neuralgia, myalgia, tendinitis, bursitis, sciatica, periarthritis, traumatic injuries of soft tissues and the musculoskeletal system; pain (postoperative, headache, toothache), dysalgomenorrhea, colds, flu (pain and fever).

Contraindications

Hypersensitivity, erosive and ulcerative lesions of the gastrointestinal tract in the acute stage, diseases of the optic nerve, “aspirin” bronchial asthma, severe disorders of the liver and kidneys, children’s age.

Dosage and administration

Information for healthcare professionals only.
Are you a healthcare professional?

By mouth, during or after a meal.

Osteoarthritis, psoriatic arthritis, spondylitis: 400-600 mg 3-4 times / day.

Rheumatoid arthritis: up to 800 mg 3 times a day, 2400 mg per day (maximum).

Juvenile rheumatoid arthritis: 30-40 mg/kg/day in divided doses.

Soft tissue injuries, sprains: 1600-2400 mg/day in divided doses.

Primary dysalgomenorrhea: 400-600 mg 3-4 times a day.

Moderate pain syndrome: 1200 mg/day in divided doses.

Side effects

Headache, dizziness, irritability, tinnitus, hearing impairment, insomnia, pathological drowsiness; nausea, heartburn, anorexia, vomiting, epigastric discomfort, flatulence, diarrhea, constipation; peripheral edema, toxic amblyopia, impaired renal function with sodium and water retention, allergic reactions, itching.

Storage conditions

At room temperature.

Keep out of reach of children.

Expiration date

3 years.

Do not use after the expiry date which is stated on the package.

Update date: 11/21/2018

Brufen 600mg №30 sachet spike granules

5

International nonproprietary name
Ibuprofen

Dosage form, dosage
Effervescent granules 600 mg.

Pharmacotherapeutic group
Musculoskeletal system. Anti-inflammatory and antirheumatic drugs. Anti-inflammatory and antirheumatic drugs, non-steroidal. propionic acid derivatives. Ibuprofen.
ATC code M01A E01

Indications for use
– rheumatoid arthritis, including juvenile arthritis, or Still-Choffard disease, ankylosing spondylitis, osteoarthritis and other non-rheumatoid (seronegative) arthropathies and acute gouty arthritis
Extra-articular rheumatic and periarticular lesions such as periarthritis of the shoulder blades (capsulitis), bursitis, tendinitis, tendosynovitis and low back pain
Soft tissue injuries such as sprains and strains of ligaments
Relief of mild to moderate pain, such as primary dysmenorrhea, dental and postoperative pain, pain after episiotomy, postpartum pain and symptomatic treatment of headache, including migraine
– hyperthermia

Checklist before use
Contraindications
– hypersensitivity to the active substance or other components of the drug
– asthma, urticaria or other allergic reactions after taking acetylsalicylic acid / aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) in history
– severe heart failure
– severe liver failure
– severe renal failure
– conditions with an increased risk of bleeding or acute bleeding
History of NSAID-related gastrointestinal bleeding or perforation
History of acute or previous ulcerative colitis, Crohn’s disease, recurrent peptic ulcer or gastrointestinal bleeding (history of two or more independent confirmed episodes ulceration or bleeding)
– third trimester of pregnancy
– lactation
– children and adolescents under 18 years of age
Precautions for use
Undesirable effects can be minimized by using the lowest effective dose for the minimum period of time necessary to control symptoms.
As with other NSAIDs, ibuprofen may mask symptoms of infection.
Long-term use of any pain medication may cause headache, which cannot be treated with an increase in the dose of the drug.
When used simultaneously with alcohol, undesirable effects associated with the active substance, especially those related to the gastrointestinal tract or the central nervous system, may be increased by the use of NSAIDs.
Elderly patients
In elderly patients, the incidence of adverse reactions with the use of NSAIDs is more frequent, especially gastrointestinal bleeding and perforation, which can be fatal.
Gastrointestinal bleeding, ulceration and perforation
Ibuprofen should be used with caution in patients with a history of peptic ulcer or other gastrointestinal (GI) disorders, as these conditions may worsen. Such patients should begin treatment at the lowest effective dose. Consideration should be given to co-prescribing protective drugs (e.g. misoprostol or proton pump inhibitors) to such patients, as well as to patients concomitantly taking low-dose acetylsalicylic acid/aspirin or other drugs that increase the risk of gastrointestinal injury.
The concomitant use of ibuprofen and other NSAIDs, including selective cyclooxygenase-2 (COX-2) inhibitors, should be avoided due to an increased risk of ulceration or bleeding.
Caution should be given to ibuprofen in patients receiving concomitant treatment with drugs that may increase the risk of ulcers or bleeding, such as oral corticosteroids, anticoagulants such as warfarin, selective serotonin reuptake inhibitors, or antiplatelet drugs, such as acetylsalicylic acid /aspirin. If gastrointestinal bleeding or ulcers develop in a patient receiving ibuprofen, the drug should be discontinued.
Respiratory disorders
Caution should be given to ibuprofen in patients suffering from bronchial asthma, chronic rhinitis or allergic diseases, as well as in patients with a history of these diseases, since it has been reported that ibuprofen can cause bronchospasm, urticaria, angioedema.
Impaired cardiac, renal and hepatic function
Caution should be given to ibuprofen in patients with impaired cardiac, renal or hepatic function, since the use of NSAIDs may lead to deterioration of renal function.
Cardiovascular and cerebrovascular effects
Ibuprofen should be used with caution in patients with a history of heart failure or hypertension, as edema has been reported with ibuprofen.
Dermatological effects
Very rarely, serious skin reactions, some of which may be fatal, have been reported with NSAIDs, including exfoliative dermatitis, Stevens-Johnson syndrome and toxic epidermal necrolysis. Acute generalized exenthematous pustulosis (AGEP) has been reported with ibuprofen-containing products. Ibuprofen should be discontinued at the first appearance of a skin rash, mucosal injury, or any other sign of hypersensitivity.
It is advisable to avoid prescribing ibuprofen if the patient is diagnosed with varicella.
Renal effects
Caution should be given to initiating ibuprofen treatment in patients with significant dehydration. There is a risk of developing renal failure, especially in children and adolescents with dehydration and in the elderly.
Discontinuation of NSAIDs is usually accompanied by recovery of the pre-treatment condition.
Hematologic effects
Ibuprofen, like other NSAIDs, may inhibit platelet aggregation and prolong bleeding time in healthy individuals.
Aseptic meningitis
In rare cases, aseptic meningitis has been observed in patients treated with ibuprofen.
Drug interactions
Precautions should be observed when prescribing with the following drugs due to possible drug interactions in some patients:
– other NSAIDs, including selective COX-2 inhibitors
– cardiac glycosides
– corticosteroids
– anticoagulants
– antiplatelet drugs and selective serotonin reuptake inhibitors
– acetylsalicylic acid/aspirin
– lithium
– antihypertensives, β-blockers and diuretics
– methotrexate
– cyclosporine
– tacrolimus
– zidovudine
– quinolone antibiotics
– inhibitor s CYP2C9
— sulfonylurea
— cholestyramine
— aminoglycosides
— mifepristone
Special warnings
Pregnancy or lactation
Brufen® granules should be avoided in patients who are pregnant or breastfeeding. Brufen® granules should not be administered at the end (last three months) of pregnancy. Brufen® granules can only be prescribed in the first six months of pregnancy, in case of emergency
Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms
Brufen® granules may cause dizziness or drowsiness. In these situations, inform the patient about the need to refuse to drive a vehicle and control potentially dangerous mechanisms.
Brufen® granules contain sucrose
Each sachet contains 3.3 g of sucrose. This should be taken into account when prescribing to patients with diabetes mellitus. Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption, or sucrose-isomaltase deficiency should not take this drug.
Brufen® granules contain sodium
When prescribing to patients on a sodium controlled diet, this should be taken into account.

Directions for Use
Dosing regimen
Adults
The recommended dose is 1200-1800 mg/day divided into several doses. For some patients, 600–1200 mg/day may be sufficient. In severe and acute cases, it is possible to increase the dose until the end of the acute phase of the disease. In this case, the maximum daily dose should not exceed 2400 mg, which are applied in several doses.
Special groups of patients
Elderly patients
There is no need to change the dose if the function of the liver or kidneys is not impaired. In case of impaired liver or kidney function, the dose of the drug should be selected individually and with caution.
Children
Brufen® in this dosage form is contraindicated for use in children.
Renal and hepatic impairment
No dose reduction required in patients with mild to moderate renal and hepatic impairment (patients with severe renal and hepatic impairment require dose adjustment).
Method and route of administration
For oral administration.
Thoroughly dissolve the granules in sufficient water before use. A transient burning sensation in the mouth or throat may occur with the use of ibuprofen granules.
Patients with a sensitive stomach are advised to take the drug with food. The drug is preferably taken with or after meals.
Frequency of Use
Take two or three times daily, up to a maximum of 4 sachets per day. Duration of treatment
The duration of treatment should be recommended by your doctor.
Precautions to be taken in case of overdose
Signs and symptoms of overdose in adults and children have not generally been observed at doses below 100 mg/kg. However, in some cases, supportive measures may be required. Children have been observed to show signs and symptoms of toxicity after ingestion of 400 mg/kg or higher.
Symptoms
Overdose symptoms develop within 4-6 hours after taking a significant amount of ibuprofen. The most common overdose symptoms include: nausea, vomiting, abdominal pain, lethargy and drowsiness, headache, tinnitus, dizziness, convulsions and loss of consciousness. Treatment
There is no specific antidote for ibuprofen overdose. In the case of a dose exceeding 400 mg / kg, it is necessary to wash the stomach and take maintenance measures within an hour from the moment of administration. Contact a Poison Control Center for the most up-to-date information.
Description of adverse reactions that occur with the standard use of drugs and measures to be taken in this case
Often
– headache, dizziness
Dyspepsia, diarrhea, nausea, vomiting, abdominal pain, flatulence, constipation, melena, hematemesis, gastrointestinal bleeding
Rash
Fatigue
Uncommon
Rhinitis
Hypersensitivity
Insomnia, restlessness liveliness
– visual impairment
– hearing impairment, tinnitus or ringing, vertigo
– asthma, bronchospasm, shortness of breath
– gastritis, duodenal ulcer and gastric ulcer, ulcerative stomatitis, gastrointestinal perforation
– hepatitis, jaundice, abnormal liver function
– urticaria, pruritus, purpura, angioedema, photosensitivity
– toxic nephropathy in various forms, including tubulointerstitial nephritis, nephrotic syndrome, renal failure
Rarely
– aseptic meningitis
– leukopenia, thrombocytopenia, neutropenia, agranulocytosis, aplastic anemia and hemolytic anemia
– anaphylactic reaction
– depression and confusion
– optic neuritis
– toxic optic neuropathy
– edema
Very rare
– pancreatitis
– liver failure
– severe skin reactions, for example, erythema multiforme, bullous reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis
– cardiac insufficiency, heart attack myocardial infarction (see section “Special instructions”)
– hypertension
Frequency unknown
– colitis and Crohn’s disease
– drug reaction with eosinophilia and systemic manifestations (DRESS syndrome)
– acute generalized exenthematous pustulosis (AGEP)
In case of adverse drug reactions, contact a healthcare professional, a pharmaceutical worker or directly to the information database on adverse reactions (actions) to drugs, including reports of drug failure
RSE on REM “National Center for Expertise of Medicines and Medical Devices” “Committee for Quality Control and Safety of Goods and Services” of the Ministry of Health of the Republic of Kazakhstan
http://www. ndda.kz

Additional information
Composition of the medicinal product
One sachet contains:
active substance – ibuprofen 600 mg,
excipients: microcrystalline cellulose, croscarmellose sodium, malic acid, sodium saccharinate, sucrose, povidone (K value from 29 to 32), orange flavor, sodium lauryl sulfate, sodium bicarbonate, sodium carbonate anhydrous.
Description of appearance, smell, taste
White granules, from small to large in size with an orange smell.

Presentation and packaging
Effervescent granules in sachets. 30 sachets, together with instructions for medical use in Kazakh and Russian, are put into a pack of cardboard.

Shelf life
3 years
Do not use after the expiry date!
Storage conditions
Store below 25°C
Keep out of the reach of children!

Pharmacy dispensing conditions
Prescription

Manufacturer details
Manufacturer/packer:
Abbwe S.r.l.
S.R. 148 Pontina km 52 snc, 04011 Campoverde di Aprilia, (LT), Italy
(tel: +39 06 92892 1, fax: +39 06 92892 7000, e-mail: abbvieitalyinfomed@abbvie.