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Acetaminophen 800 mg: Comprehensive Guide to Uses, Dosage, and Safety Precautions

How does acetaminophen 800 mg work to relieve pain and fever. What are the potential side effects and interactions of acetaminophen. When should you seek medical attention while taking acetaminophen 800 mg. How can you safely use acetaminophen for children and adults.

Understanding Acetaminophen: A Powerful Pain Reliever and Fever Reducer

Acetaminophen, also known as paracetamol in many countries, is a widely used over-the-counter medication for treating mild to moderate pain and reducing fever. The 800 mg dosage is a potent formulation often prescribed for more intense pain relief. This article delves into the various aspects of acetaminophen 800 mg, providing comprehensive information on its uses, proper dosage, potential side effects, and crucial safety precautions.

What is Acetaminophen and How Does It Work?

Acetaminophen belongs to a class of drugs called analgesics (pain relievers) and antipyretics (fever reducers). It works by altering the way the body senses pain and by cooling the body. Unlike nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen doesn’t reduce inflammation. Its exact mechanism of action is not fully understood, but it’s believed to work by inhibiting the synthesis of prostaglandins in the central nervous system.

Common Uses of Acetaminophen 800 mg

Acetaminophen 800 mg is primarily used for:

  • Relieving headaches, including migraines
  • Easing menstrual cramps
  • Alleviating toothache pain
  • Reducing backaches
  • Managing osteoarthritis pain
  • Treating cold and flu symptoms
  • Lowering fever

Is acetaminophen 800 mg suitable for all types of pain? While it’s effective for many types of pain, it may not be the best choice for inflammatory conditions. In such cases, NSAIDs might be more appropriate. Always consult with a healthcare professional to determine the most suitable pain management strategy for your specific condition.

Proper Dosage and Administration of Acetaminophen 800 mg

Proper dosing of acetaminophen is crucial for its effectiveness and safety. The 800 mg dose is typically prescribed for adults and adolescents over 12 years old. Here are some key points to remember:

  • Follow the prescribed dosage or package instructions carefully
  • Do not exceed 4000 mg (4 grams) of acetaminophen in 24 hours for adults
  • Space doses at least 4-6 hours apart
  • Use the provided measuring device for liquid formulations
  • Do not crush or chew extended-release tablets

Can you take acetaminophen 800 mg on an empty stomach? Yes, acetaminophen can be taken with or without food. However, if you experience stomach upset, taking it with food may help alleviate this side effect.

Special Considerations for Children

Acetaminophen dosage for children is based on weight and age. The 800 mg dose is typically too high for most children. Parents should:

  • Use children’s formulations of acetaminophen
  • Calculate dosage based on the child’s weight when possible
  • Never exceed the recommended dose or frequency
  • Consult a pediatrician before giving acetaminophen to infants under 3 months old

Potential Side Effects and Risks of Acetaminophen 800 mg

While acetaminophen is generally well-tolerated, it can cause side effects, especially when taken in high doses or for prolonged periods. Common side effects may include:

  • Nausea
  • Stomach pain
  • Loss of appetite
  • Headache
  • Skin rash or itching

What are the signs of an acetaminophen overdose? Symptoms of overdose can include nausea, vomiting, loss of appetite, sweating, extreme fatigue, yellowing of the skin or eyes (jaundice), and dark urine. If you suspect an overdose, seek immediate medical attention, even if you feel well, as liver damage can occur before symptoms appear.

Liver Toxicity: A Serious Concern

The most significant risk associated with acetaminophen is liver damage. This risk increases with:

  • Taking more than the recommended dose
  • Using multiple products containing acetaminophen
  • Consuming alcohol while taking acetaminophen
  • Having pre-existing liver conditions

How can you protect your liver while taking acetaminophen 800 mg? Always adhere to the recommended dosage, avoid alcohol consumption, and be aware of other medications that may contain acetaminophen to prevent accidental overdose.

Drug Interactions and Precautions with Acetaminophen 800 mg

Acetaminophen can interact with various medications and substances. It’s crucial to inform your healthcare provider about all medications, supplements, and herbal products you’re taking. Some notable interactions include:

  • Warfarin (increased risk of bleeding)
  • Isoniazid (increased risk of liver toxicity)
  • Carbamazepine (reduced effectiveness of acetaminophen)
  • Alcohol (increased risk of liver damage)

Are there any conditions that contraindicate the use of acetaminophen 800 mg? Acetaminophen should be used with caution or avoided in individuals with liver disease, alcohol abuse, or a history of acetaminophen sensitivity. Pregnant and breastfeeding women should consult their healthcare provider before using high doses of acetaminophen.

Safe Storage and Disposal of Acetaminophen

Proper storage and disposal of acetaminophen are essential for safety and effectiveness. Follow these guidelines:

  • Store at room temperature, away from moisture and heat
  • Keep out of reach of children and pets
  • Do not use expired medication
  • Dispose of unused medication properly through drug take-back programs or as advised by your pharmacist

Why is proper disposal of acetaminophen important? Improper disposal can lead to environmental contamination and potential misuse. Many pharmacies and local health departments offer safe disposal options for unused medications.

Alternatives to Acetaminophen 800 mg

While acetaminophen is effective for many types of pain and fever, it may not be suitable for everyone. Alternative pain management options include:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen
  • Topical pain relievers
  • Physical therapy
  • Acupuncture
  • Cognitive behavioral therapy for chronic pain

When should you consider alternatives to acetaminophen 800 mg? If acetaminophen isn’t providing adequate pain relief, causes side effects, or is contraindicated due to liver issues or other health concerns, discussing alternative options with your healthcare provider is advisable.

Monitoring and Follow-up While Using Acetaminophen 800 mg

Regular monitoring is important when using acetaminophen 800 mg, especially for long-term use. This may include:

  • Periodic liver function tests
  • Assessing the effectiveness of pain relief
  • Evaluating the need for continued use or dose adjustment
  • Monitoring for any signs of adverse effects

How often should you have follow-up appointments when taking acetaminophen 800 mg regularly? The frequency of follow-ups depends on individual factors such as age, overall health, and reason for use. Generally, individuals taking high doses of acetaminophen long-term should have liver function tests at least annually or as recommended by their healthcare provider.

When to Seek Medical Attention

While acetaminophen is generally safe when used as directed, there are situations where immediate medical attention is necessary. Seek help if you experience:

  • Signs of allergic reaction (rash, itching, swelling, severe dizziness, difficulty breathing)
  • Symptoms of liver problems (yellowing of skin/eyes, dark urine, persistent nausea/vomiting, severe abdominal pain)
  • Unusual bleeding or bruising
  • Persistent fever or pain that doesn’t improve with treatment

Acetaminophen 800 mg is a potent and effective medication for pain relief and fever reduction when used correctly. Understanding its proper use, potential risks, and necessary precautions is crucial for safe and effective treatment. Always consult with a healthcare professional for personalized advice, especially if you have any underlying health conditions or are taking other medications. By following these guidelines and maintaining open communication with your healthcare provider, you can maximize the benefits of acetaminophen while minimizing potential risks.

Acetaminophen Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Warnings:

Taking too much acetaminophen may cause serious (possibly fatal) liver disease. Adults should not take more than 4000 milligrams (4 grams) of acetaminophen a day. People with liver problems and children should take less acetaminophen. Ask your doctor or pharmacist how much acetaminophen is safe to take.

Do not use with any other drug containing acetaminophen without asking your doctor or pharmacist first. Acetaminophen is in many nonprescription and prescription medications (such as pain/fever drugs or cough-and-cold products). Check the labels on all your medicines to see if they contain acetaminophen, and ask your pharmacist if you are unsure.

Get medical help right away if you take too much acetaminophen (overdose), even if you feel well. Overdose symptoms may include nausea, vomiting, loss of appetite, sweating, stomach/abdominal pain, extreme tiredness, yellowing eyes/skin, and dark urine.

Daily alcohol use, especially when combined with acetaminophen, may damage your liver. Avoid alcohol.

Warnings:

Taking too much acetaminophen may cause serious (possibly fatal) liver disease. Adults should not take more than 4000 milligrams (4 grams) of acetaminophen a day. People with liver problems and children should take less acetaminophen. Ask your doctor or pharmacist how much acetaminophen is safe to take.

Do not use with any other drug containing acetaminophen without asking your doctor or pharmacist first. Acetaminophen is in many nonprescription and prescription medications (such as pain/fever drugs or cough-and-cold products). Check the labels on all your medicines to see if they contain acetaminophen, and ask your pharmacist if you are unsure.

Get medical help right away if you take too much acetaminophen (overdose), even if you feel well. Overdose symptoms may include nausea, vomiting, loss of appetite, sweating, stomach/abdominal pain, extreme tiredness, yellowing eyes/skin, and dark urine.

Daily alcohol use, especially when combined with acetaminophen, may damage your liver. Avoid alcohol.

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Uses

This drug is used to treat mild to moderate pain (from headaches, menstrual periods, toothaches, backaches, osteoarthritis, or cold/flu aches and pains) and to reduce fever.

How to use Acetaminophen

Take this product by mouth as directed. Follow all directions on the product package. If you have any questions, ask your doctor or pharmacist.

There are many brands and forms of acetaminophen available. Read the dosing instructions carefully for each product because the amount of acetaminophen may be different between products. Do not take more acetaminophen than recommended. (See also Warning section.)

If you are giving acetaminophen to a child, be sure you use a product that is meant for children. Use your child’s weight to find the right dose on the product package. If you don’t know your child’s weight, you can use their age.

For suspensions, shake the medication well before each dose. Some liquids do not need to be shaken before use. Follow all directions on the product package. Measure the liquid medication with the provided dose-measuring spoon/dropper/syringe to make sure you have the correct dose. Do not use a household spoon.

For rapidly-dissolving tablets, chew or allow to dissolve on the tongue, then swallow with or without water. For chewable tablets, chew thoroughly before swallowing.

Do not crush or chew extended-release tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Swallow the tablets whole.

For effervescent tablets, dissolve the dose in the recommended amount of water, then drink.

Pain medications work best if they are used as the first signs of pain occur. If you wait until the symptoms have worsened, the medication may not work as well.

Do not take this medication for fever for more than 3 days unless directed by your doctor. For adults, do not take this product for pain for more than 10 days (5 days in children) unless directed by your doctor. If the child has a sore throat (especially with high fever, headache, or nausea/vomiting), consult the doctor promptly.

Tell your doctor if your condition lasts or gets worse or if you develop new symptoms. If you think you may have a serious medical problem, get medical help right away.

Side Effects

See also Warning section.

This drug usually has no side effects. If you have any unusual effects, contact your doctor or pharmacist promptly.

If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

See also Warning section.

Before taking acetaminophen, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this product, tell your doctor or pharmacist your medical history, especially of: liver disease, regular use/abuse of alcohol.

Liquid products, chewable tablets, or dissolving/effervescent tablets and powders may contain sugar or aspartame. Caution is advised if you have diabetes, phenylketonuria (PKU), or any other condition that requires you to limit/avoid these substances in your diet. If you have any of these conditions, ask your doctor or pharmacist about using these products safely.

Tell your doctor if you are pregnant before using this medication.

Acetaminophen passes into breast milk. Consult your doctor before breast-feeding.

Interactions

See also Warning section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug are: ketoconazole, levoketoconazole.

This medication may interfere with certain lab tests, possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.

Does Acetaminophen interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: nausea, vomiting, loss of appetite, sweating, stomach/abdominal pain, extreme tiredness, yellowing eyes/skin, dark urine.

If you are taking this medication on a regular schedule and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Acetaminophen Interactions Checker – Drugs.com

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There are 112 drugs known to interact with
acetaminophen, along with
3 disease interactions, and 1 alcohol/food interaction.

Of the total drug interactions,
7 are major, 70 are moderate, and 35 are minor.

Does acetaminophen interact with my other drugs?

Enter other medications to view a detailed report.

  • View all 112 medications that may interact with acetaminophen
  • View acetaminophen alcohol/food interactions (1)
  • View acetaminophen disease interactions (3)

Most frequently checked interactions

View interaction reports for acetaminophen and the medicines listed below.

  • Major
  • Moderate
  • Minor
  • Unknown
  • Aspir 81 (aspirin)
  • Aspirin Low Strength (aspirin)
  • Benadryl (diphenhydramine)
  • Calcium 600 D (calcium / vitamin d)
  • Claritin (loratadine)
  • Colace (docusate)
  • CoQ10 (ubiquinone)
  • Cymbalta (duloxetine)
  • Eliquis (apixaban)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • Flonase (fluticasone nasal)
  • Lasix (furosemide)
  • Lexapro (escitalopram)
  • Lipitor (atorvastatin)
  • Lyrica (pregabalin)
  • Metoprolol Succinate ER (metoprolol)
  • Metoprolol Tartrate (metoprolol)
  • Milk of Magnesia (magnesium hydroxide)
  • MiraLAX (polyethylene glycol 3350)
  • Mucinex (guaifenesin)
  • Norco (acetaminophen / hydrocodone)
  • ProAir HFA (albuterol)
  • Probiotic Formula (bifidobacterium infantis / lactobacillus acidophilus)
  • Synthroid (levothyroxine)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin C (ascorbic acid)
  • Vitamin D3 (cholecalciferol)
  • Xanax (alprazolam)
  • Zofran (ondansetron)
  • Zyrtec (cetirizine)

Acetaminophen alcohol/food interactions

There is 1 alcohol/food interaction with acetaminophen.

Acetaminophen disease interactions

There are 3 disease interactions with acetaminophen which include:

  • alcoholism
  • liver disease
  • PKU

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  • Reviews (100)
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  • During pregnancy
  • Support group
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Drug Interaction Classification
These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
MajorHighly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
ModerateModerately clinically significant. Usually avoid combinations; use it only under special circumstances.
MinorMinimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
UnknownNo interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Acetaminophen (paracetamol)

Paracetamol/acetaminophen is an anilide medicine used for mild to moderate pain, fever and colds.

Synonyms Russian

N-(4-Hydroxyphenyl)acetamide, C 8 H 9 NO 2, ifimol.

English synonyms

Paracetamol, Acetaminophen, Ifimol.

Test method

High performance liquid chromatography with tandem mass spectrometry.

Units

µg/mL (micrograms per milliliter).

What biomaterial can be used for research?

Venous blood.

How to properly prepare for an examination?

  • Children under 1 year of age do not eat for 30-40 minutes before the test.
  • Do not eat for 2-3 hours before the study, you can drink clean still water.
  • Do not smoke for 30 minutes before the test.

Study background

Paracetamol/acetaminophen is one of the most popular and most commonly used pain and fever reducers worldwide. It serves as the drug of choice for patients who are contraindicated in non-steroidal anti-inflammatory drugs (NSAIDs), in people with bronchial asthma, peptic ulcer, hemophilia, among children, pregnant and lactating women. Paracetamol is well tolerated and causes few gastrointestinal side effects with the correct dosage regimen, however, the number of reported cases of paracetamol-induced liver damage is steadily increasing every year worldwide.

Paracetamol is an antipyretic analgesic, that is, a drug with analgesic, antipyretic and weak anti-inflammatory action. The mechanism of action is associated with the inhibition of prostaglandin synthesis, the predominant effect on the thermoregulatory center in the hypothalamus by reducing its excitability. Paracetamol therapy is effective, well tolerated by most patients, and safe when used at therapeutic doses. However, the use of paracetamol, even at therapeutic doses in underweight individuals who abuse alcohol, or when taken with other drugs, can cause serious liver damage. In addition, paracetamol is “hidden” in other drugs under different names. Long-term use of high doses of paracetamol is associated with the risk of adverse reactions such as hypertension, myocardial infarction or renal failure. In addition, the side effects of paracetamol include agranulocytosis, thrombocytopenia, anemia, renal colic, aseptic pyuria, interstitial glomerulonephritis, allergic reactions in the form of skin rashes. Symptoms of an overdose of the drug include pallor, nausea, vomiting and pain in the abdominal region, after 12-48 hours damage to the kidneys and liver may begin with the development of liver failure (encephalopathy, coma, death), cardiac arrhythmias and pancreatitis.

The use of paracetamol in children requires special care and the choice of an adequate dosage (depending on age), which differs significantly from the standard adult.

What is research used for?

  • Detection of the toxic level of the drug.
  • Monitoring of the concentration of paracetamol in the blood.
  • Evaluation of drug interactions.

When is the test ordered?

  • If an overdose of the drug is suspected.
  • With the development of side effects of paracetamol.

What do the results mean?

Reference values: 10 – 20 µg/ml.

The results of the study are evaluated by the attending physician, taking into account the dose of paracetamol, its regimen, the patient’s age, comorbidities and individual drug tolerance.

After a single dose of 500 mg, the maximum plasma concentration is reached after 10-60 minutes and is about 6 mcg / ml, then gradually decreases and after 6 hours is 11-12 mcg / ml.

What can influence the result?

  • Metoclopramide increases the rate of absorption of acetaminophen.
  • Colestyramine reduces the rate of absorption of acetaminophen.

Important notes

  • Paracetamol increases the risk of hemorrhagic complications.
  • Concomitant use of paracetamol and alcoholic beverages increases the risk of liver damage and acute pancreatitis.
  • Hypnotic drugs increase the side effects of paracetamol, can lead to liver damage even with non-toxic doses of paracetamol, so liver function should be monitored.
  • Long-term co-administration of paracetamol and NSAIDs increases the risk of developing nephropathy and end-stage renal disease.
  • Paracetamol increases the effect of indirect anticoagulants, so INR should be monitored.
  • Taking paracetamol increases the chance of liver damage from hepatotoxic drugs.

Who orders the examination?

Therapist, hepatologist, nephrologist, rheumatologist, toxicologist.

Literature

  • Jóźwiak-BebenistaM, NowakJZ. Paracetamol: mechanism of action, applications and safety concern. Acta Pol Pharm. 2014 Jan-Feb;71(1):11-23. PMID: 24779190.
  • https://www. rlsnet.ru/mnn_index_id_500.htm.
  • https://www.vidal.ru/drugs/molecule/800.

Acetaminophen0001

0.045 ‰

Analogs

All forms of release, dosages, registration certificates, drug manufacturers, drug characteristics

Description of the drug Acetaminophen (tablets, 500 mg) based on the official instructions, approved by the manufacturer in 1997

Date approved: 07/31/1997

Content

  • Active substance
  • ATX
  • Pharmacological group
  • Nosological classification (ICD-10)
  • Composition and form of release
  • pharmachologic effect
  • Indications
  • Contraindications
  • Use during pregnancy and lactation
  • Dosage and administration
  • Side effects
  • Storage conditions
  • Best before date
  • Reviews

Active ingredient

Paracetamol* (Paracetamol*)

ATX

N02BE01 Paracetamol

Pharmacological group

Anilides

Nosological classification (ICD-10)

ICD-10 code list

  • G43 Migraine
  • K13. 7 Other and unspecified lesions of oral mucosa
  • M79.2 Neuralgia and neuritis, unspecified
  • N94.6 Dysmenorrhea, unspecified
  • R50 Fever of unknown origin
  • R51 Headache
  • R52.2 Other persistent pain

Composition and formulation

1 tablet contains paracetamol 500 mg; in a package of 12 and 30 pcs.