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Aleve cold and sinus side effects: Aleve-D Sinus & Cold Uses, Side Effects & Warnings

Aleve Cold And Sinus D

Are you tired of dealing with the discomfort of cold and sinus symptoms? Look no further than Aleve Cold And Sinus D! In this comprehensive guide, we will explore everything you need to know about this powerful over-the-counter medication.

What is Aleve Cold And Sinus D?

Aleve Cold And Sinus D is a popular medication that provides effective relief from cold and sinus symptoms. It combines the power of two active ingredients: pseudoephedrine and naproxen sodium.

  • Pseudoephedrine: This ingredient helps relieve nasal congestion by shrinking the blood vessels in the nasal passages. It also reduces sinus pressure and promotes sinus drainage.
  • Naproxen Sodium: This nonsteroidal anti-inflammatory drug (NSAID) helps alleviate sinus headache and other pain associated with cold and sinus symptoms.

How Does Aleve Cold And Sinus D Work?

Aleve Cold And Sinus D works by targeting the root causes of cold and sinus symptoms. Pseudoephedrine acts as a decongestant, reducing nasal congestion and sinus pressure. Naproxen sodium provides pain relief and reduces inflammation, helping to alleviate sinus headache.

Dosage and Administration

It is important to follow the recommended dosage and administration instructions for Aleve Cold And Sinus D to ensure safe and effective use. Here are some key points to keep in mind:

  • Adults and children 12 years and older should take 1 tablet every 12 hours.
  • Do not exceed 2 tablets in 24 hours.
  • Swallow the tablet whole with water, and do not crush or chew it.
  • Consult a healthcare professional before giving this medication to children under 12 years of age.

Potential Side Effects

While Aleve Cold And Sinus D is generally well-tolerated, it may cause some side effects in certain individuals. Common side effects may include:

  • Upset stomach
  • Nausea
  • Headache
  • Dizziness

If you experience any severe or persistent side effects, it is important to seek medical attention.

Frequently Asked Questions

Q: Can I take Aleve Cold And Sinus D if I have high blood pressure?

A: It is important to consult a healthcare professional before taking Aleve Cold And Sinus D if you have high blood pressure or any other underlying medical conditions.

Q: Can I take Aleve Cold And Sinus D with other medications?

A: Certain medications may interact with Aleve Cold And Sinus D, so it is important to check with a healthcare professional or pharmacist before combining medications.

Q: How long can I take Aleve Cold And Sinus D?

A: Aleve Cold And Sinus D is intended for short-term use. If your symptoms persist or worsen, consult a healthcare professional.

Q: Can I drive or operate machinery while taking Aleve Cold And Sinus D?

A: Aleve Cold And Sinus D may cause drowsiness or dizziness in some individuals. If you experience these side effects, avoid driving or operating machinery.


Aleve Cold And Sinus D is a trusted and effective medication for relieving cold and sinus symptoms. With its powerful combination of pseudoephedrine and naproxen sodium, it provides relief from nasal congestion, sinus pressure, and sinus headache. Remember to follow the recommended dosage and consult a healthcare professional if you have any concerns. Say goodbye to cold and sinus discomfort with Aleve Cold And Sinus D!

Please note: This blog post is for informational purposes only and should not be considered medical advice. Always consult a healthcare professional before starting any new medication.


  • https://www.healthcare.gov/glossary/urgent-care/
  • https://urgentcareassociation.org/

Pseudoephedrine: MedlinePlus Drug Information

pronounced as (soo doe e fed’ rin)

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  • Why is this medication prescribed?
  • How should this medicine be used?
  • Other uses for this medicine
  • What special precautions should I follow?
  • What special dietary instructions should I follow?
  • What should I do if I forget a dose?
  • What side effects can this medication cause?
  • What should I know about storage and disposal of this medication?
  • In case of emergency/overdose
  • What other information should I know?
  • Brand names
  • Brand names of combination products

Pseudoephedrine is used to relieve nasal congestion caused by colds, allergies, and hay fever. It is also used to temporarily relieve sinus congestion and pressure. Pseudoephedrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. Pseudoephedrine is in a class of medications called nasal decongestants. It works by causing narrowing of the blood vessels in the nasal passages.

Pseudoephedrine comes as a regular tablet, a 12-hour extended-release (long-acting) tablet, a 24-hour extended-release tablet, and a solution (liquid) to be taken by mouth. The regular tablets and liquid are usually taken every 4 to 6 hours. The 12-hour extended-release tablets usually are taken every 12 hours, and you should not take more than two doses in a 24-hour period. The 24-hour extended-release tablets usually are taken once a day, and you should not take more than one dose in a 24-hour period. To help prevent trouble sleeping, take the last dose of the day several hours before bedtime. Follow the directions on the package label or on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take pseudoephedrine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor or directed on the label.

Pseudoephedrine comes alone and in combination with other medications. Ask your doctor or pharmacist for advice on which product is best for your symptoms. Check nonprescription cough and cold product labels carefully before using 2 or more products at the same time. These products may contain the same active ingredient(s) and taking them together could cause you to receive an overdose. This is especially important if you will be giving cough and cold medications to a child.

Nonprescription cough and cold combination products, including products that contain pseudoephedrine, can cause serious side effects or death in young children. Do not give nonprescription pseudoephedrine products to children younger than 4 years of age. If you give these products to children 4-11 years of age, use caution and follow the package directions carefully. Do not give pseudoephedrine extended-release tablets to children younger than 12 years of age.

If you are giving pseudoephedrine or a combination product that contains pseudoephedrine to a child, read the package label carefully to be sure that it is the right product for a child of that age. Do not give pseudoephedrine products that are made for adults to children.

Before you give a pseudoephedrine product to a child, check the package label to find out how much medication the child should receive. Give the dose that matches the child’s age on the chart. Ask the child’s doctor if you don’t know how much medication to give the child.

If you are taking the liquid, do not use a household spoon to measure your dose. Use the measuring spoon or cup that came with the medication or use a spoon made especially for measuring medication.

If your symptoms do not get better within 7 days or if you have a fever, stop taking pseudoephedrine and call your doctor.

Swallow the extended-release tablets whole; do not break, crush, or chew them.

This medication is also sometimes used to prevent ear pain and blockage caused by pressure changes during air travel or underwater diving. Talk to your doctor or pharmacist for more information.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking pseudoephedrine,

  • tell your doctor and pharmacist if you are allergic to pseudoephedrine, any other medications, or any of the inactive ingredients in the pseudoephedrine product you plan to take. Check the package label for a list of the ingredients.
  • do not take pseudoephedrine if you are taking a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate), or if you have stopped taking one of these medications within the past 2 weeks.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention medications for diet or appetite control, asthma, colds, or high blood pressure.
  • tell your doctor if you have or have ever had high blood pressure, glaucoma (a condition in which increased pressure in the eye can lead to gradual loss of vision), diabetes, difficulty urinating (due to an enlarged prostate gland), or thyroid or heart disease. If you plan to take the 24-hour extended-release tablets, tell your doctor if you have had a narrowing or blockage of your digestive system.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking pseudoephedrine, call your doctor.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking pseudoephedrine.

Foods and drinks that contain large amounts of caffeine can make the side effects of pseudoephedrine worse.

This medication is usually taken as needed. If your doctor has told you to take pseudoephedrine regularly, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Pseudoephedrine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • restlessness
  • nausea
  • vomiting
  • weakness
  • headache

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:

  • nervousness
  • dizziness
  • difficulty sleeping
  • stomach pain
  • difficulty breathing
  • fast, pounding, or irregular heartbeat

Pseudoephedrine may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online (http://www. fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.

  • Afrinol®
  • Cenafed®
  • Children’s Sudafed Nasal Decongestant®
  • Congestaclear®
  • Efidac®
  • Myfedrine®
  • Pseudocot®
  • Ridafed®
  • Silfedrine®
  • Sudafed 12/24 Hour®
  • Sudafed Congestion®
  • Sudodrin®
  • SudoGest®
  • Sudrine®
  • Superfed®
  • Suphedrin®
  • Allegra-D® (as a combination product containing Fexofenadine, Pseudoephedrine)
  • AccuHist DM® (containing Brompheniramine, Dextromethorphan, Guaifenesin, Pseudoephedrine)§
  • Advil Allergy Sinus® (containing Chlorpheniramine, Ibuprofen, Pseudoephedrine)
  • Advil Cold and Sinus® (containing Ibuprofen, Pseudoephedrine)
  • Alavert Allergy and Sinus D-12® (containing Loratadine, Pseudoephedrine)
  • Aldex GS® (containing Guaifenesin, Pseudoephedrine)
  • Aldex GS DM® (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)
  • Aleve-D Sinus and Cold® (containing Naproxen, Pseudoephedrine)
  • Allergy Relief D® (containing Cetirizine, Pseudoephedrine)
  • Ambifed® (containing Guaifenesin, Pseudoephedrine)§
  • Ambifed DM® (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§
  • Biodec DM® (containing Dextromethorphan, Pseudoephedrine)§
  • BP 8® (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§
  • Brofed® (containing Brompheniramine, Pseudoephedrine)§
  • Bromdex® (containing Brompheniramine, Dextromethorphan, Pseudoephedrine)§
  • Bromfed® (containing Brompheniramine, Pseudoephedrine)§
  • Bromfed DM® (containing Brompheniramine, Dextromethorphan, Pseudoephedrine)
  • Bromhist DM® (containing Brompheniramine, Dextromethorphan, Guaifenesin, Pseudoephedrine)§
  • Bromphenex DM® (containing Brompheniramine, Dextromethorphan, Pseudoephedrine)
  • Bromuphed® (containing Brompheniramine, Pseudoephedrine)§
  • Bromuphed PD® (containing Brompheniramine, Pseudoephedrine)§
  • Brotapp® (containing Brompheniramine, Pseudoephedrine)
  • Brotapp-DM Cold and Cough® (containing Brompheniramine, Dextromethorphan, Pseudoephedrine)
  • Brovex PSB® (containing Brompheniramine, Pseudoephedrine)
  • Brovex PSB DM® (containing Brompheniramine, Dextromethorphan, Pseudoephedrine)
  • Brovex SR® (containing Brompheniramine, Pseudoephedrine)§
  • Carbofed DM® (containing Brompheniramine, Dextromethorphan, Pseudoephedrine)§
  • Certuss-D® (containing Chlophedianol, Guaifenesin, Pseudoephedrine)
  • Cetiri-D® (containing Cetirizine, Pseudoephedrine)
  • Children’s Advil Cold® (containing Ibuprofen, Pseudoephedrine)
  • Children’s Motrin Cold® (containing Ibuprofen, Pseudoephedrine)
  • Chlorfed A SR® (containing Chlorpheniramine, Pseudoephedrine)§
  • Clarinex-D® (containing Desloratadine, Pseudoephedrine)
  • Claritin-D® (containing Loratadine, Pseudoephedrine)
  • Coldamine® (containing Chlorpheniramine, Methscopolamine, Pseudoephedrine)§
  • Coldmist DM® (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§
  • Coldmist LA® (containing Guaifenesin, Pseudoephedrine)§
  • Colfed A® (containing Chlorpheniramine, Pseudoephedrine)§
  • Corzall® (containing Carbetapentane, Pseudoephedrine)§
  • Dallergy PSE® (containing Chlorpheniramine, Methscopolamine, Pseudoephedrine)§
  • Deconamine® (containing Chlorpheniramine, Pseudoephedrine)§
  • Deconomed SR® (containing Chlorpheniramine, Pseudoephedrine)§
  • Defen LA® (containing Guaifenesin, Pseudoephedrine)§
  • Dimetane DX® (containing Brompheniramine, Dextromethorphan, Pseudoephedrine)
  • Drixoral® (containing Dexbrompheniramine, Pseudoephedrine)
  • Drymax® (containing Chlorpheniramine, Methscopolamine, Pseudoephedrine)§
  • Dynahist ER® (containing Chlorpheniramine, Pseudoephedrine)§
  • EndaCof-DC® (containing Codeine, Pseudoephedrine)
  • EndaCof-PD® (containing Brompheniramine, Dextromethorphan, Pseudoephedrine)§
  • Entex PSE® (containing Guaifenesin, Pseudoephedrine)§
  • Exall D® (containing Carbetapentane, Guaifenesin, Pseudoephedrine)§
  • ExeFen DMX® (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)
  • ExeFen IR® (containing Guaifenesin, Pseudoephedrine)
  • Guaidex TR® (containing Chlorpheniramine, Dextromethorphan, Guaifenesin, Methscopolamine, Pseudoephedrine)§
  • Hexafed® (containing Dexchlorpheniramine, Pseudoephedrine)§
  • Histacol DM® (containing Brompheniramine, Guaifenesin, Dexchlorpheniramine, Pseudoephedrine)§
  • Histex® (containing Chlorpheniramine, Pseudoephedrine)§
  • Lodrane® (containing Brompheniramine, Pseudoephedrine)§
  • LoHist-D® (containing Chlorpheniramine, Pseudoephedrine)§
  • LoHist-PD® (containing Brompheniramine, Pseudoephedrine)§
  • LoHist-PSB® (containing Brompheniramine, Pseudoephedrine)
  • LoHist-PSB-DM® (containing Brompheniramine, Dextromethorphan, Pseudoephedrine)
  • Lortuss DM® (containing Dextromethorphan, Doxylamine, Pseudoephedrine)
  • Lortuss EX® (containing Codeine, Guaifenesin, Pseudoephedrine)
  • Lortuss LQ® (containing Doxylamine, Pseudoephedrine)
  • Medent DM® (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§
  • Medent LD® (containing Guaifenesin, Pseudoephedrine)§
  • Mintex® (containing Chlorpheniramine, Pseudoephedrine)§
  • Mucinex D® (containing Guaifenesin, Pseudoephedrine)
  • Myphetane Dx® (containing Brompheniramine, Dextromethorphan, Pseudoephedrine)§
  • Nalex® (containing Guaifenesin, Pseudoephedrine)§
  • Nasatab LA® (containing Guaifenesin, Pseudoephedrine)§
  • Neutrahist® (containing Chlorpheniramine, Pseudoephedrine)§
  • Notuss-NXD® (containing Chlorcyclizine, Codeine, Pseudoephedrine)§
  • Pediahist DM® (containing Brompheniramine, Dextromethorphan, Guaifenesin, Pseudoephedrine)§
  • Polyvent® (containing Guaifenesin, Pseudoephedrine)§
  • Pseudodine® (containing Pseudoephedrine, Triprolidine)
  • Relcof PSE® (containing Chlorpheniramine, Methscopolamine, Pseudoephedrine)§
  • Respa 1st® (containing Guaifenesin, Pseudoephedrine)§
  • Respaire® (containing Guaifenesin, Pseudoephedrine)§
  • Respivent D® (containing Chlorpheniramine, Methscopolamine, Pseudoephedrine)§
  • Rezira® (containing Hydrocodone, Pseudoephedrine)
  • Rondamine DM® (containing Dextromethorphan, Pseudoephedrine)§
  • Rondec® (containing Brompheniramine, Pseudoephedrine)§
  • Rondec DM® (containing Dextromethorphan, Pseudoephedrine)§
  • Ru-Tuss DM® (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§
  • Semprex-D® (containing Acrivastine, Pseudoephedrine)
  • Suclor® (containing Chlorpheniramine, Pseudoephedrine)§
  • Sudafed 12 Hour Pressure/Pain® (containing Naproxen, Pseudoephedrine)
  • Sudafed Triple Action® (containing Acetaminophen, Guaifenesin, Pseudoephedrine)
  • Sudahist® (containing Chlorpheniramine, Pseudoephedrine)§
  • Sudatex DM® (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§
  • Sudatrate® (containing Methscopolamine, Pseudoephedrine)§
  • Tekral® (containing Diphenhydramine, Pseudoephedrine)§
  • Tenar DM® (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§
  • Tenar PSE® (containing Guaifenesin, Pseudoephedrine)§
  • Theraflu Max-D Severe Cold and Flu® (containing Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine)
  • Touro CC® (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§
  • Touro LA® (containing Guaifenesin, Pseudoephedrine)§
  • Triacin® (containing Pseudoephedrine, Triprolidine)
  • Trikof D® (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§
  • Trispec PSE® (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§
  • Tussafed LA® (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§
  • Tylenol Sinus Severe Congestion Daytime® (containing Acetaminophen, Guaifenesin, Pseudoephedrine)
  • Vanacof® (containing Chlophedianol, Dexchlorpheniramine, Pseudoephedrine)
  • Vanacof DX® (containing Chlophedianol, Guaifenesin, Pseudoephedrine)
  • Viravan P® (containing Pseudoephedrine, Pyrilamine)§
  • Viravan PDM® (containing Dextromethorphan, Pseudoephedrine, Pyrilamine)§
  • Z-Cof DM® (containing Dextromethorphan, Guaifenesin, Pseudoephedrine)§
  • Zodryl DEC® (containing Codeine, Guaifenesin, Pseudoephedrine)
  • Zutripro® (containing Chlorpheniramine, Hydrocodone, Pseudoephedrine)
  • Zymine DRX® (containing Pseudoephedrine, Triprolidine)§
  • Zyrtec-D® (containing Cetirizine, Pseudoephedrine)

§ These products are not currently approved by the FDA for safety, effectiveness, and quality. Federal law generally requires that prescription drugs in the U.S. be shown to be both safe and effective prior to marketing. Please see the FDA website for more information on unapproved drugs (http://www.fda.gov/AboutFDA/Transparency/Basics/ucm213030.htm) and the approval process (http://www.fda.gov/Drugs/ResourcesForYou/Consumers/ucm054420.htm).

This branded product is no longer on the market. Generic alternatives may be available.

Last Revised – 02/15/2018

Browse Drugs and Medicines

Naproxen and Pseudoephedrine | Memorial Sloan Kettering Cancer Center

Adult Medication


This document, provided by Lexicomp ® , contains all the information you need to know about this medicine, including indications, directions for use, side effects, and when your healthcare provider should be contacted.

Trade names: USA

Aleve-D Sinus & Cold [OTC] [DSC]; Aleve-D Sinus & Headache [OTC]; Sudafed 12 Hour Pressure + Pain [OTC]


  • This drug may increase the risk of heart and blood vessel problems such as myocardial infarction and stroke. These effects can be deadly. This risk may be increased if you have heart disease or risk factors for heart disease. However, the risk may be increased even for people who do not have or are at risk of developing heart disease. The risk may occur during the first weeks of using this drug and may increase with higher doses or long-term use. This drug should not be used immediately before or after coronary bypass surgery.
  • This drug may increase the chance of developing severe and sometimes deadly stomach or intestinal problems, such as ulcers or bleeding. The risk is increased in the elderly and in people who have previously had ulcers or bleeding in the stomach or intestines. Such disturbances can occur suddenly.

What is this drug used for?

  • The drug is used to treat blockage of the nasal valve.
  • It is used to relieve pain and reduce high fever.

What should I tell my doctor BEFORE taking this drug?

For all patients taking this drug:
  • If you have an allergy to this drug, any of its ingredients, other drugs, foods or substances. Tell your doctor about your allergies and how they have manifested.
  • If you are allergic to aspirin or non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or naproxen.
  • If you have ever had asthma caused by salicylates, such as aspirin, or drugs such as this drug, such as non-steroidal anti-inflammatory drugs (NSAIDs).
  • If you have any of the following health problems: gastrointestinal bleeding or kidney problems.
  • If you have any of the following health conditions: Heart failure (weak heart) or a recent heart attack.
  • If you have taken medications for depression or Parkinson’s disease in the past 14 days. These include isocarboxazid, phenelzine, tranylcypromine, selegiline, or rasagiline. An episode of very high blood pressure may occur.
  • If you are taking an NSAID, a salicylate such as aspirin, or pemetrexed.
  • If you are unable to conceive or are testing to see if you are able to conceive.
  • If you are pregnant, plan to become pregnant, or become pregnant while taking this drug. If you take this drug after 20 weeks of pregnancy, it may harm the fetus. If you are 20 to 30 weeks pregnant, take this drug only as directed by your doctor. Do not use this drug after 30 weeks of pregnancy.
  • If the patient is a child under 12 years of age. Do not give this drug to children under 12 years of age.

This list of drugs and conditions that may interact with this drug is not exhaustive.

Tell your doctor and pharmacist about all medicines you take (prescription and over-the-counter, natural products and vitamins) and any health problems you have. You need to make sure that this drug is safe for your conditions and in combination with other drugs you are already taking. Do not start or stop taking any drug or change the dosage without your doctor’s advice.

What do I need to know or do while taking this drug?

  • Tell all your health care workers that you are taking this drug. These are doctors, nurses, pharmacists and dentists.
  • Do not take the drug in higher doses than prescribed by your doctor. Taking more than the prescribed amount of the drug increases the risk of serious side effects.
  • Do not take this drug for longer than the length of time your doctor has prescribed.
  • Consult your doctor before drinking alcohol.
  • If you smoke, please consult your doctor.
  • If you have asthma, check with your doctor. You may be more sensitive to the drug.
  • The use of drugs of this kind was accompanied by high blood pressure. Monitor your blood pressure as directed by your doctor.
  • There is an increased chance of bleeding. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
  • The risk of developing heart failure increases with the use of drugs of this kind. People with heart failure have an increased risk of myocardial infarction, hospitalization for heart failure, and death. Consult your doctor.
  • People who have had a heart attack and are taking this type of drug are at increased risk of having another heart attack and dying from a heart problem. People who took drugs of this kind after their first myocardial infarction were also more likely to die one year after myocardial infarction than those who did not take such drugs. Consult your doctor.
  • If you are taking aspirin to prevent myocardial infarction, talk to your doctor.
  • Other drugs of this kind have been associated with severe and sometimes fatal reactions. In most cases, this reaction was accompanied by symptoms such as fever, rash, inflammation of the lymph nodes, and dysfunction of various organs such as the liver, kidneys, blood, heart, muscles, joints and lungs. If you have any questions, please consult your doctor.
  • If you are 60 years of age or older, take this drug with caution. You may experience more side effects.
  • Non-steroidal anti-inflammatory drugs (NSAIDs), such as this drug, may interfere with the release of an egg (ovulation). This can negatively affect the ability to get pregnant. As a rule, the process of ovulation is restored after stopping this drug. Consult your doctor.
  • Tell your doctor if you are breastfeeding. It is necessary to consult whether the drug poses any risk to the child.

What side effects should I report to my doctor immediately?

WARNING. In rare cases, this drug can cause serious and sometimes deadly side effects in some patients. Contact your doctor or seek medical attention right away if you have any of the following signs or symptoms that may be associated with serious side effects:

  • Signs of an allergic reaction, such as rash, hives, itching, red and swollen skin with blisters or peeling, possibly accompanied by fever, wheezing or wheezing, tightness in the chest or throat, difficulty breathing, swallowing or speaking, unusual hoarseness, swelling in the mouth, face, lips, tongue or throat.
  • signs of bleeding, such as vomiting or coughing up blood; vomiting of the type of coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; non-cyclic vaginal bleeding; bruises that appear or increase for no reason; bleeding that you cannot stop.
  • Signs of kidney problems, including not passing urine, changes in the volume of urine, blood in the urine, or rapid weight gain.
  • Signs of elevated potassium levels such as feeling of an abnormal heartbeat, confusion, feeling weak or dizzy, feeling faint, feeling numb or tingly, or short of breath.
  • Signs of high blood pressure, such as a very severe headache, or dizziness, or loss of consciousness, or blurred vision.
  • Weakness on 1 side of the body, difficulty speaking or thinking, problems with balance, sagging on one side of the face, or blurred vision.
  • Shortness of breath, sudden weight gain, or swelling of the arms or legs.
  • Pain or pressure in the chest or a fast heartbeat.
  • Severe dizziness or fainting.
  • Feeling extremely tired or weak.
  • Tinnitus.
  • Flu-like symptoms.
  • Swelling of the gland.
  • The use of drugs like this has been associated with liver problems. In some cases, this has led to death. Call your doctor right away if you develop signs of liver problems such as dark urine, fatigue, lack of appetite, nausea or abdominal pain, light-colored stools, vomiting, yellowing of the skin or eyes.

What are some other side effects of this drug?

Any medicine can have side effects. However, for many people, side effects are either minor or non-existent. Contact your doctor or seek medical attention if these or any other side effects bother you or do not go away:

  • Dizziness.
  • Nervous tension and agitation.
  • Sleep disorders.
  • Abdominal pain or heartburn.
  • Nausea or vomiting.

This list of possible side effects is not exhaustive. If you have any questions about side effects, please contact your doctor. Talk to your doctor about side effects.

You can report side effects to the National Health Board.

You can report side effects to the FDA at 1-800-332-1088. You can also report side effects at https://www.fda.gov/medwatch.

What is the best way to take this drug?

Use this drug as directed by your doctor. Read all the information provided to you. Strictly follow all instructions.

  • Take with or without food. Take with food if medicine causes nausea.
  • Take this drug with a full glass of water.
  • Swallow whole. Do not chew, break or crush.

What if I miss a dose of a drug?

  • If you take the drug regularly, take the missed dose as soon as you can.
  • If it’s time to take your next dose, don’t take the missed dose and then go back to your regular dosing schedule.
  • Do not take 2 doses or an additional dose at the same time.
  • In most cases, this drug is used as needed. Do not take the drug more often than prescribed by your doctor.

How do I store and/or discard this drug?

  • Store at room temperature in a dry place. Do not store in the bathroom.
  • Keep all medicines in a safe place. Keep all medicines out of the reach of children and pets.
  • Dispose of unused or expired drugs. Do not empty into a toilet or sewer unless instructed to do so. If you have any questions about disposing of medicines, ask your pharmacist. Drug recycling programs may be in place in your area.

General information about medicines

  • If your health does not improve or even worsens, see your doctor.
  • Do not give your medicine to anyone and do not take other people’s medicines.
  • Some medicines may come with other patient information leaflets. If you have any questions about this drug, talk with your doctor, nurse, pharmacist, or other health care professional.
  • Some medicines may come with other patient information leaflets. Check with your pharmacist. If you have any questions about this drug, talk with your doctor, nurse, pharmacist, or other health care professional.
  • If you think you have overdosed, call a poison control center or get medical help right away. Be prepared to tell or show what drug you took, how much, and when it happened.

Consumer Use of Information and Limitation of Liability

This summary information includes a summary of the diagnosis, treatment, and/or drug product. It is not intended to be a comprehensive source of data and should be used as a tool to help the user understand and/or evaluate potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a particular patient. It should not be considered medical advice or a substitute for medical advice, diagnosis or treatment provided by a physician based on a medical examination and assessment of the patient’s specific and unique circumstances. Patients should consult with their physician for full information about their health, medical issues, and treatment options, including any risks or benefits regarding the use of medications. This information is not a guarantee that a treatment or drug is safe, effective, or approved for a particular patient. UpToDate, Inc. and its subsidiaries disclaim any warranties or liabilities related to this information or its use. The use of this information is subject to the Terms of Use found at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms.

Last revision date



© UpToDate, Inc. and its affiliates and/or licensors, 2023. All rights reserved.

Date last updated

Monday, December 12, 2022

Tylenol PM vs Motrin PM

: What is the difference?

30 points

Motrin PM

66 points

Tylenol PM

Comparison winner


59 facts in comparison

Motrin PM

Tylenol PM

Why is Motrin PM better than Tylenol PM?

  • Anti-inflammatory?
  • 200mg contains more ibuprofen?
    200mg vs 0mg
  • 13mg contains more Diphenhydramine?
    38mg vs 25mg
  • Not related to low blood pressure?

Why is Tylenol PM better than Motrin PM?

  • 500mg more paracetamol?
    500mg vs 0mg
  • Not addictive?
  • Migraine?
  • Can be used to treat colds and flu?
  • 20 more tablets per box?
    100 vs 80
  • 4 longer treatment period?
    14 vs 10
  • Can be taken on an empty stomach?
  • Not related to dyspnea?

Motrin PM



Tylenol PM


Tylenol Extra Strength

Motrin PM


Motrin IB

Tylenol PM


Tylenol Regular Strength

Motrin PM


Excedrin PM

Tylenol PM


Tylenol Arthritis Pain

Motrin PM


Dolormin für Frauen

Tylenol PM

vs. 02 Motrin PM


IbuHEXAL akut 400 mg

Tylenol PM


Panadol Night

Motrin PM


Children’s Motrin

Tylenol PM


Excedrin PM

Motrin PM


Aleve Tablets

Tylenol PM


Tylenol PM


Tylenol Sinus Congestion & Pain Severe

Ty lenol PM





Ibuprofen is a non-steroidal anti-inflammatory drug. The analgesic effect of ibuprofen takes effect immediately, however, the anti-inflammatory effects can last up to a week.


Paracetamol (acetaminophen in the US) is classified as a mild analgesic. It suppresses the feeling of pain, but does not treat the cause.


Aspirin can be used as an analgesic, antipyretic and anti-inflammatory agent.


Studies have shown that caffeine can increase the effectiveness of many analgesics, resulting in better, faster pain relief.


Codeine is an opiate used to treat mild to moderate pain. Opioids can change mood, sometimes resulting in a feeling of euphoria. It may be helpful in relieving pain, but addiction and withdrawal symptoms may occur.

Has more than one active ingredient

✔Motrin PM

✔Tylenol PM

The product contains more than one active ingredient. These combinations usually complement each other, and sometimes one ingredient can enhance the effectiveness of another.


Naproxen is an anti-inflammatory that can be used to treat a variety of pain symptoms.


For toothache

✔Motrin PM

✔Tylenol PM

Toothache is pain in and around the teeth and jaw, often caused by caries.


✔Motrin PM

✖Tylenol PM

Anti-inflammatory drugs are especially good for muscle and joint pain because they not only block the pain, but also treat the cause.

Antipyretic (reduces body temperature)

✔Motrin PM

✔Tylenol PM

Antipyretic drugs help to reduce body temperature. This helps patients feel better, however, this is not always recommended as fever may be a natural defense against infections.

Rheumatic pain

✖Motrin PM

✖Tylenol PM

Rheumatic pain is pain in the joints and connective tissue, most commonly caused by arthritis.

Muscle pain

✔Motrin PM

✔Tylenol PM

Muscle pain can be caused by exercise or other stress, as well as infections such as the flu.


✖Motrin PM

✔Tylenol PM

Migraine is a very severe headache often accompanied by other symptoms such as flickering light, blind spots, tingling and sensitivity to light. Migraine sufferers often find it difficult to find adequate relief.

Does not cause bloating

✖Motrin PM

✖Tylenol PM

Bloating, usually in the abdomen, causes discomfort. This is usually caused by a buildup of liquid or gas.

Not related to constipation

✖Motrin PM

✖Tylenol PM

Constipation means that there is difficulty with regular bowel movements.