Aleve d side effects: Aleve-D Sinus & Cold Uses, Side Effects & Warnings

03.02.202125.07.2023 by alexxlab

Содержание

Aleve-D Sinus & Cold Tablet – Product

Aleve-D Sinus & Cold Tablet – Product – TabletWise

About

About Us
Privacy Policy
Terms of Service

TabletWise

Overview
Uses
Side-effects
Precautions
Interactions
Contraindications

Overview

Aleve-D Sinus & Cold Tablet is used for Sinus congestion, Pain, Fever, Osteitis deformans, Bartter’s syndrome, Nasal congestion and other conditions. Aleve-D Sinus & Cold Tablet may also be used for purposes not listed in this medication guide.

Aleve-D Sinus & Cold Tablet contains Naproxen Sodium and Pseudoephedrine Hydrochloride as active ingredients.

Aleve-D Sinus & Cold Tablet works by blocking cyclooxygenase to prevent prostaglandins synthesis; narrowing the blood vessels to decrease swelling and congestion;

Detailed information related to Aleve-D Sinus & Cold Tablet’s uses, composition, dosage, side effects and reviews is listed below.

Uses

Aleve-D Sinus & Cold Tablet is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:

Sinus congestion
Pain
Fever
Osteitis deformans
Bartter’s syndrome
Nasal congestion
Aleve-D Sinus & Cold Tablet may also be used for purposes not listed here.

Learn more: Uses

Side-effects

The following is a list of possible side-effects that may occur from all constituting ingredients of Aleve-D Sinus & Cold Tablet. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.

Constipation
Heartburn
Abdominal pain
Nausea
Drowsiness
Headache
Dizziness
Sweating
Diarrhea
Mental depression
Nervousness
Irritability
Fatigue
Malaise
Insomnia
Fast or uneven heartbeat
Easy bruising
Weakness
Fever
Chills
Body ache
Flu symptoms
High blood pressure
Aleve-D Sinus & Cold Tablet may also cause side-effects not listed here.

If you notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority.

Precautions

Before using Aleve-D Sinus & Cold Tablet, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side-effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.

Do not drive or operate machinery
Limit alcoholic beverages
Pregnant, planning to get pregnant or breastfeeding
Take this medicine with a full glass of water
do not drive or operate machinery

Interactions with Aleve-D Sinus & Cold Tablet

If you use other drugs or over the counter products at the same time, the effects of Aleve-D Sinus & Cold Tablet may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Aleve-D Sinus & Cold Tablet may interact with the following drugs and products:

Amitriptyline
Atenolol
Carvedilol
Cimetidine
Doxepin
Furosemide
Lithium
Probenecid
Warfarin

When not to use Aleve-D Sinus & Cold Tablet

Hypersensitivity to Aleve-D Sinus & Cold Tablet is a contraindication. In addition, Aleve-D Sinus & Cold Tablet should not be used if you have the following conditions:

Children under the age of 4 years
Hypersensitivity
Monoamine oxidase inhibitors
asthma
hypersensitivity
urticaria

Composition and Active Ingredients

Packages and Strengths

Aleve-D Sinus & Cold Tablet is available in the following packages and strengths

Aleve-D Sinus & Cold Tablet – Packages: 200MG, 120MG

Frequently asked Questions

Is Aleve-D Sinus & Cold Tablet safe to use when pregnant?
- Naproxen Sodium: No
- Pseudoephedrine Hydrochloride: Please consult with your doctor for case-specific recommendations.
Is Aleve-D Sinus & Cold Tablet safe while breastfeeding?
- Naproxen Sodium: No
- Pseudoephedrine Hydrochloride: No
Can Aleve-D Sinus & Cold Tablet be used for sinus congestion and pain?
Yes, sinus congestion and pain are among the most common reported uses for Aleve-D Sinus & Cold Tablet. Please do not use Aleve-D Sinus & Cold Tablet for sinus congestion and pain without consulting first with your doctor. Click here and view survey results to find out what other patients report as common uses for Aleve-D Sinus & Cold Tablet.
Should I use Aleve-D Sinus & Cold Tablet empty stomach, before food or after food?
TabletWise.com website users have most commonly reported using Aleve-D Sinus & Cold Tablet after food. However, this may not be reflective of how you should use this medicine. Please follow your doctor’s advice on how you should use this medicine. Click here and view survey results to find out what other patients report as timing of using Aleve-D Sinus & Cold Tablet.
Is it safe to drive or operate heavy machinery when using this product?
If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Aleve-D Sinus & Cold Tablet medicine then it may not be safe to drive a vehicle or operate heavy machinery. One should not drive a vehicle if using the medicine makes you drowsy, dizzy or lowers your blood-pressure extensively. Pharmacists also advise patients not to drink alcohol with medicines as alcohol intensifies drowsiness side-effects. Please check for these effects on your body when using Aleve-D Sinus & Cold Tablet. Always consult with your doctor for recommendations specific to your body and health conditions.
Is this medicine or product addictive or habit forming?
Most medicines don’t come with a potential for addiction or abuse. Usually, the government’s categorizes medicines that can be addictive as controlled substances. Examples include schedule H or X in India and schedule II-V in the US. Please consult the product package to make sure that the medicine does not belong to such special categorizations of medicines. Lastly, do not self-medicate and increase your body’s dependence to medicines without the advice of a doctor.
Can i stop using this product immediately or do I have to slowly wean off the use?
Some medicines need to be tapered or cannot be stopped immediately because of rebound effects. Please consult with your doctor for recommendations specific to your body, health and other medications that you may be using.

Cite this page

Page URL

HTML Link

APA Style Citation

Aleve-D Sinus & Cold Tablet – Product – tabletwise.net. (n.d.). Retrieved April 14, 2023, from https://www. tabletwise.net/us/aleve-d-sinus-and-cold-tablet

MLA Style Citation

“Aleve-D Sinus & Cold Tablet – Product – tabletwise.net” Tabletwise.com. N.p., n.d. Web. 14 Apr. 2023.

Chicago Style Citation

“Aleve-D Sinus & Cold Tablet – Product – tabletwise.net” Tabletwise. Accessed April 14, 2023. https://www.tabletwise.net/us/aleve-d-sinus-and-cold-tablet.

More about Aleve-D Sinus & Cold Tablet

Uses
Reviews

What are the uses of Aleve-D Sinus & Cold Tablet?
What are the side-effects of Aleve-D Sinus & Cold Tablet?
What other medicines does Aleve-D Sinus & Cold Tablet interact with?
When should you not use Aleve-D Sinus & Cold Tablet?
What precautions should you take while using Aleve-D Sinus & Cold Tablet?

Last updated date

This page was last updated on 9/27/2020.

This page provides information for Aleve-D Sinus & Cold Tablet Product in English.

Pain
Pain is a feeling triggered in the nervous system. Pain may be …
Fever
A fever is a body temperature that is higher than normal. It is …
Paget’s Disease of Bone
Paget’s disease of bone causes your bones to grow too large and …
Bartter’s Syndrome
A rare inherited syndrome characterized by juxtaglomerular cell …

Learn More

Pain

Pain is a feeling triggered in the nervous system. Pain may be …

Fever

A fever is a body temperature that is higher than normal. It is …

Paget’s Disease of Bone

Paget’s disease of bone causes your bones to grow too large and …

Bartter’s Syndrome

A rare inherited syndrome characterized by juxtaglomerular cell …

Pain

Fever

Paget’s Disease of Bone

Bartter’s Syndrome

Share with friends, get 20% off

Invite your friends to TabletWise learning marketplace. For each purchase they make, you get 20% off (upto $10) on your next purchase.

Aleve (Naproxen) Side Effects

Health Conditions
- Featured
  - Breast Cancer
  - IBD
  - Migraine
  - Multiple Sclerosis (MS)
  - Rheumatoid Arthritis
  - Type 2 Diabetes
- Articles
  - Acid Reflux
  - ADHD
  - Allergies
  - Alzheimer’s & Dementia
  - Bipolar Disorder
  - Cancer
  - Crohn’s Disease
  - Chronic Pain
  - Cold & Flu
  - COPD
  - Depression
  - Fibromyalgia
  - Heart Disease
  - High Cholesterol
  - HIV
  - Hypertension
  - IPF
  - Osteoarthritis
  - Psoriasis
  - Skin Disorders and Care
  - STDs
Discover
- Wellness Topics
  - Nutrition
  - Fitness
  - Skin Care
  - Sexual Health
  - Women’s Health
  - Mental Well-Being
  - Sleep
- Product Reviews
  - Vitamins & Supplements
  - Sleep
  - Mental Health
  - Nutrition
  - At-Home Testing
  - CBD
  - Men’s Health
- Original Series
  - Fresh Food Fast
  - Diagnosis Diaries
  - You’re Not Alone
  - Present Tense
- Video Series
  - Youth in Focus
  - Healthy Harvest
  - No More Silence
  - Future of Health
Plan
- Health Challenges
  - Mindful Eating
  - Sugar Savvy
  - Move Your Body
  - Gut Health
  - Mood Foods
  - Align Your Spine
- Find Care
  - Primary Care
  - Mental Health
  - OB-GYN
  - Dermatologists
  - Neurologists
  - Cardiologists
  - Orthopedists
- Lifestyle Quizzes
  - Weight Management
  - Am I Depressed? A Quiz for Teens
  - Are You a Workaholic?
  - How Well Do You Sleep?
- Tools & Resources
  - Health News
  - Find a Diet
  - Find Healthy Snacks
  - Drugs A-Z
  - Health A-Z
Connect
- - Breast Cancer
  - Inflammatory Bowel Disease
  - Psoriatic Arthritis
  - Migraine
  - Multiple Sclerosis
  - Psoriasis

Medically reviewed by Alan Carter, Pharm. D. — By University of Illinois — Updated on May 18, 2017

Overview

Aleve is one brand of the over-the-counter drug naproxen sodium 220 milligrams (mg). It treats many types of mild pain. You may have taken it to treat your headaches, menstrual cramps, arthritis, muscles aches, toothaches, backaches, and even mild fever. If you take Aleve, though, you may wonder what else it does in your body.

Although Aleve can bring relief, it can also cause side effects. Some of these side effects can happen just from short-term use. Long-term use of Aleve can also cause other side effects. Some people are at greater risk of Aleve side effects because of certain medical conditions that they have.

Here’s what to know about how Aleve works and the side effects it can cause.

Aleve, or naproxen sodium 220 mg, is the over-the-counter version of naproxen sodium 275 mg, which is available by prescription only. Aleve is closely related to naproxen base 250 mg, also prescription only.

Both Aleve and its prescription counterparts belong to a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). These drugs reduce pain and fever by preventing your body from making prostaglandins. Prostaglandins are substances your body produces when tissues of your body are injured. These substances contribute to many of the effects of inflammation, including swelling, fever, and pain.

Inhibiting your body’s production of prostaglandins can help prevent pain and other effects related to inflammation. But it can also interfere with some other functions.

Prostaglandins naturally help protect your stomach from damage. When Aleve reduces your prostaglandin production, it can cause:

stomach pain
constipation
diarrhea
gas
heartburn
nausea or vomiting

These effects are more likely the older you are or the longer you use Aleve.

More serious side effects include:

swelling
bleeding
ulcers
tears in your stomach, small intestine, or large intestine

These effects can be fatal and can happen without warning. If you notice severe stomach pain or bloody or black, tarry stools while you take Aleve, stop taking the drug and call your doctor right away. To lower your risk of digestive system side effects, use the lowest effective dosage for the shortest time.

Aleve can also increase your blood pressure. You might not notice any signs that your blood pressure is increased. And if you already have high blood pressure, taking Aleve might make it worse. You should talk to your doctor before using Aleve if you have high blood pressure.

Aleve can also reduce your blood’s ability to clot. This can lead to bleeding. Talk to your doctor before using Aleve if you plan on having surgery soon.

Long-term use of Aleve can make your heart work harder. Aleve makes you retain water, which increases the load on your heart. This extra work can cause pressure on your cardiovascular system and can sometimes lead to a heart attack or stroke. These risks are even greater at higher dosages, even if you don’t have any heart conditions or risk of heart disease. Call 911 or local emergency services if you have:

chest pain
shortness of breath
slurred speech
weakness in your arms or legs

These are signs of a stroke or heart attack. If you take Aleve and have unexplained weight gain or swelling, especially in your legs and feet, talk to your doctor right away. These may be signs of heart failure. To lower your risk of heart problems, use the lowest dosage for the shortest amount of time.

Prostaglandins maintain the pressure in your kidneys so that these organs can filter the fluids in your body. A decrease in your level of prostaglandins from taking Aleve can cause problems with your kidney function. You may notice fluid retention or changes in how much you urinate. If you notice these changes while taking Aleve, stop taking it and contact your doctor.

People with certain medical conditions may experience more side effects from Aleve than other people. These conditions include:

history of stomach ulcers or stomach bleeding
kidney disease
heart disease
liver disease

If you have any of these conditions, talk to your doctor before using Aleve. Your doctor may suggest another medication to avoid complications.

For most people, Aleve is an effective treatment for mild pain and fever, especially for short-term use. Side effects can occur, but for the most part the effects are mild. Typically, more severe side effects are associated with extended use. But, as with any medication, if you have a medical condition, take other drugs, or simply aren’t sure if you should take it, talk to your doctor.

Last medically reviewed on May 16, 2017

How we reviewed this article:

Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

Grosser T, et al. (2011). Chapter 34: Anti-inflammatory, antipyretic, and analgesic agents; pharmacotherapy of gout. The pharmacological basis of therapeutics, 12th edition.
accessbiomedicalscience.mhmedical.com/content.aspx?sectionid=102161048&bookid=1613
Label: Naprosyn – naproxen tablet; EC-naprosyn – naproxen tablet, delayed release; Naprosyn – naproxen suspension; Anaprox – naproxen sodium tablet; Anaprox DS – naproxen sodium tablet. (2016).
dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=68848217-03c9-4377-9be6-6f567e629129
Naproxen. (2015).
nlm.nih.gov/medlineplus/druginfo/meds/a681029.html
Risser A, et al. (2009). NSAID prescribing precautions.
aafp.org/afp/2009/1215/p1371.html

Share this article

Medically reviewed by Alan Carter, Pharm.D. — By University of Illinois — Updated on May 18, 2017

Ryazan State Medical University named after Academician I.P. Pavlov

Ryazan State Medical University named after academician I.P. Pavlov – official site

Admission Committee +7 (4912) 97-18-48

Admission Committee +7 (4912) 97-1 8-48

Admissions office +7 (4912) 97-18-48

Reception Committee +7 (4912) 97-18-48

900 02 Admission Committee +7 (4912) 97-18-48

Admission Committee +7 (4912) 97-18-48

Additional professional education (4912) 97-18-37

Additional professional education (4912) 97-18-37 90 003

Additional professional education (4912) 97-18-37

Additional e vocational education (4912) 97-18-37

Additional vocational education (4912) 97-18-37

NAME IN THE HISTORY OF RYAZGMU

NAME IN THE HISTORY RYAZGMU

NAME IN THE HISTORY RYAZ State Medical University

NAME IN THE HISTORY RYAZGMU

University in ratings

University in rankings

University rankings

University in ratings

Science news in RyazSMU

Science news in RyazSMU 9000 3

Science news in RyazGMU

9 0002 Science news at Ryazan State Medical University

05/30/2023

Admission Campaign – 2023

On our website in the section Home / Applicants / Applicants (specialist / bachelor / master) there is a video that details the rules for admission to Ryazan State Medical University.

07/25/2023

THREE STAGES FOR ADMISSION TO EXTRA-BUDGETARY PLACES

07/21/2023

PATENT REGISTERED FOR ENDOSCOPIC LOOP
As a result of the joint work of scientists from the Department of Urology with the course of surgical diseases of the Ryazan State Medical University and the endoscopic department of the Mytishchi City Clinical Hospital, an endoscopic ligation loop was developed and put into practice, designed to prevent bleeding during interventions in flexible endoscopic surgery.

07/18/2023

ATTENTION, APPLICANTS!
On the official website in the section “Applicants / Applicants (specialist / bachelor’s / master’s) / Progress of the admission campaign” there are lists of applicants who have submitted documents, indicating the points awarded for individual achievements.

07/17/2023

LIPETSK EMERGENCY HOSPITAL AND RYAZGMU COMBINE TO CREATE A CENTER FOR ADDITIONAL EDUCATION
On July 14, RyazGMU Rector Roman Kalinin and Chief Physician of the Lipetsk City Emergency Hospital N1 Dmitry Pavlyukevich signed a cooperation agreement.

07/14/2023

New clinical base of Ryazan State Medical University
A cooperation agreement was signed with the Neuroclinic Center, a medical and pedagogical institution in the city of Ryazan.

07/14/2023

EP candidates for the City Duma
The rector of the Ryazan State Medical University, Professor Kalinin Roman Evgenievich, was included in the list of candidates for deputies of the Ryazan City Representative Assembly.

07/13/2023

Participate in the action “Welcome to the village”
Medical volunteers of the Ryazan State Medical University as part of a team of specialists from the Center for Public Health work in small towns of the Ryazan region.

07/13/2023

SCIENTIFIC TOURISM
The initiative is aimed at attracting young people to unique and exciting complex tours in Russia.

07/13/2023

“Give me life!”
University students took an active part in the All-Russian action with the same name.

News

14.02.2023

TELL YOU WHO IS ALREADY AVAILABLE ONLINE PAYMENT FOR TRAINING IN RYAZGMU

Now all students of the FDPO RyazGMU can pay for training without leaving their homes. You can pay online and without commission using the new service pay.rzgmu.ru

09/23/2022

News FDPO RyazGMU

04/04/2023

Course “PSYCHOLOGICAL METHODS OF WORK WITH THE CONSEQUENCES OF PSYCHOTRAUFUL EVENTS”
Additional professional advanced training program “Psychological methods of working with the consequences of traumatic events” was developed for specialists with a psychological education.

02/28/2023

SWIMMING IN THE MEDICAL SENSE IS USEFUL FOR ABSOLUTELY EVERYONE
Why – says Valery Grigorievich Demikhov, Doctor of Medical Sciences, Professor, Director of the Scientific and Clinical Center for Hematology, Oncology and Immunology, Ryazan State Medical University of the Ministry of Health of Russia

22.02.2023

DEPARTURE TO THE NOVOMOSKOVSK CITY CLINICAL HOSPITAL
On February 16, a visit to the State Healthcare Institution “Novomoskovsk City Clinical Hospital” took place. On behalf of the Ministry of Health of the Tula region, tests were prepared to assess the knowledge of obstetrician-gynecologists. Head of the Department of Obstetrics and Gynecology of the Ryazan State Medical University Kovalenko M.S. and Dean of the FDPO RyazGMU Maksimtseva E.A. tested 21 specialists of the State Healthcare Institution “NGCH” and conducted a clinical tour of the departments of branch No. 2 of the State Health Institution “NGCH” together with the Deputy Chief Physician for Obstetrics and Gynecology Breus E.V. and department staff.

22.02.2023

TRAINING UNDER THE PROGRAM “NURSING IN PEDIATRICS” IS COMPLETED
On February 16, the 144-hour advanced training program “Nursing in Pediatrics” ended. During the training, nurses in the Ryazan region improved their knowledge and skills in nursing care for a healthy and sick child with infectious and somatic pathology, prevention of somatic and infectious pathology in childhood in accordance with the regulatory framework, professional standards and clinical recommendations.

02/16/2023

WetLab

02/14/2023

BASIC EMERGENCY FIRST AID COURSE

02/14/2023

COURSE “METHODS OF NON-TEST PSYCHODIAGNOSIS OF PERSONALITY”

27.09.2022

Russian as a foreign language (speech practice course)

FDPO

07/19/2023

“PSYCHOLOGY AND MEDICINE-2023: INTERNATIONAL CONFERENCE OF STUDENTS AND YOUNG SCIENTISTS

On November 23-24, 2023, the anniversary X International Conference of Students and Young Scientists “Psychology and Medicine: Ways to Find Optimal Interaction – 2023” “Health and Psychological Well-Being of the Personality” will be held.

06/20/2023

INTESTINAL OBSTRUCTION IN CHILDREN OVER THE NEWBORN PERIOD
Dear Colleagues! We invite you to the scientific and educational school “Intestinal obstruction in children older than the neonatal period”, which will be held on June 23, 2023. The event will discuss topical issues of diagnosis, treatment and tactics of the surgeon in intestinal obstruction in children.

06/20/2023

SCIENTIFIC AND PRACTICAL CONFERENCE
High-profile specialists in the field of neonatology and obstetrics will make presentations on June 23, 2023 at the Ryazan State Medical University.

06/15/2023

Learning to write dissertations
The Council of Young Scientists of the Ryazan State Medical University will hold a meeting for graduate students, applicants and young scientists with Doctor of Medical Sciences Professor Elena Nikolaevna Yakusheva

09. 06.2023

Conference of psychologists
We invite you to take part in the student scientific and practical conference “Formation of professional research competence of future clinical psychologists”

06/02/2023

I Congress of Therapists of the Central Federal District
8-9June at the Ryazan State Medical University will host a forum focused on practical healthcare professionals. The organizers are RNMOT, the Ministry of Health of the Ryazan Region and the Ryazan State Medical University.

06/02/2023

In June, the second cycle of training “Fundamentals of Kinesiology Taping” starts
The cycle is intended for everyone, regardless of the presence or absence of a medical education. Listeners have the opportunity to get or improve the skill of using elastic bands, to learn everything or almost everything about teips!

29.05.2023

Physical and Rehabilitation Medicine in Pediatrics
On June 3, 2023, the University will host the Interregional Scientific and Practical Conference “Physical and Rehabilitation Medicine in Pediatrics”. Beginning at 10.00 in the hall of the Academic Council, at the address: Ryazan, st. Vysokovoltnaya, d. 7, bldg. 1, 4th floor.

05/25/2023

Mental health service: achievements and prospects
We invite you to take part in the IX Interregional Scientific and Practical Conference “Mental Health Service: Achievements and Prospects. Dedicated to the 135th anniversary of the Ryazan Regional Clinical Psychiatric Hospital. N.N. Bazhenov”, which will be held on June 2, 2023 on the basis of the Ryazan Regional Clinical Psychiatric Hospital. Bazhenova N.N.

05/22/2023

WE INVITE YOU TO READ THE PROGRAM OF THE CONFERENCE “TOPICAL ISSUES OF THERAPY AND GENERAL MEDICAL PRACTICE”

Announcements

Register of medicines of Russia RLS Patient 2003.

Back

Table of contents
Forward

Undesirable drug effects and their causes. Side effects, allergic reactions to the drug, overdose. How to avoid drug side effects?

Everyone who has ever taken a medicine knows that it can not only treat a disease, but also have side effects. And even if the doctor does not warn about the presence of side effects in the drug, then in the leaflet to the drug, a separate line lists all those undesirable effects that may occur during treatment with this drug. What is it, side effect ? And is it possible to do without it?

Chapter 2.5 states that the effect of most drugs is based on their physicochemical or chemical interaction with cell membrane receptors. As a result of this, certain changes occur in all cells that have receptors that “recognize” this drug. Their summation leads to a change in the functions of a tissue, organ or organ system, which is the purpose of the drug, that is, its therapeutic effect. For example, blood pressure decreases, pain subsides, swelling decreases, and so on. But the matter is not limited to the therapeutic effect. A drug with exceptional selectivity is an ideal, a “magic bullet”, precisely aimed at a sore spot and not touching healthy tissues. In real life, the action of most drugs resembles a multi-colored mosaic. This is due to several reasons. First, the administered medicine does not only get to the right place. In the body, it is carried by the blood to all tissues and meets with components of cell membranes ( receptors ) capable of interacting with it. And healthy cells have receptors that can bind to drugs. This leads to a change in their functions, and, therefore, to any pharmacological effect. For example, we lowered the pressure, but diarrhea appeared or the heart rate increased. These effects will no longer be curative, because the patient took this drug for another purpose. Secondly, part of the drug, as we already know from the previous chapters, undergoes transformation under the action of the body’s defense systems ( biotransformation ) and loses its original pharmacological activity, but the resulting substances (metabolites) may have some new biological properties and cause various effects.

Drugs have the main therapeutic effect, which is expected when using the drug in each specific case (for example, analgesics are used to relieve pain, antihypertensive drugs are used to lower blood pressure, and so on). Sometimes there are several such therapeutic effects, and two or three of the most pronounced ones determine both the main pharmacological effect of the drug and the indications for its use.

For example, for preparations containing loratadine as an active substance, the column “pharmacological action” indicates: antiallergic, antipruritic, antiexudative. In sodium bicarbonate , more commonly known as baking soda, the pharmacological action is antacid, expectorant, restoring the alkaline state of the blood – it all depends on the route of administration, dosage form and dose.

Effects that are not directed against the disease, beyond the purpose for which the drug is taken, are called side effects. By definition, side effects drugs are undesirable effects that are part of the spectrum of pharmacological activity of the drug and occur when the drug is used in therapeutic doses (not in cases of overdose).

	Side effects can occur with all medications. Their frequency reaches 10-20%. Ask the doctor who prescribed this drug for possible side effects of the medicine.

Lacking sufficient selectivity, drugs affect the functions of many tissues and organs (including those not affected by the disease). Some negative effects of the medicinal product that do not go beyond the resistance zone in terms of intensity or duration of exposure, the body can “neutralize on its own”. In other cases, when the state of the organism as a system has gone beyond the stability zone, a side effect of the drug appears.

Side effects may be primary or secondary. The primary effect occurs as a direct consequence of the influence of this drug on the substrate, for example, when the substance irritates the gastric mucosa, nausea, vomiting, and pain occur. Secondary side effects develop indirectly as a result of taking the drug, for example, hypovitaminosis and dysbacteriosis when the intestinal microflora is suppressed by antibiotics. More on this will be discussed a little later.

For acetylsalicylic acid , which, by the way, refers to over-the-counter drugs, the “Side effect” column in the instructions or in the reference book takes more than one line. “Tinnitus, dizziness, hearing loss, epigastric pain, heartburn, nausea and vomiting, severe bleeding from the gastrointestinal tract, thrombocytopenia, anemia, leukopenia, Reye’s syndrome, hypersensitivity reactions (bronchospasm, laryngeal edema and urticaria), “aspirin” bronchial asthma, interstitial nephritis, acute renal failure … “We will not list all the side effects … ” . However, judge for yourself how balanced the decision to take any drug should be.

	Carefully read the instructions for use of the drug, especially the columns “Side effect”, “Contraindications”, “Overdose”, “Precautions”, “Special instructions”.

nausea, headache, etc. ) and disappear after discontinuation or reduction in the dosage of the drug. However, there are those that can be severe and even life-threatening for the patient (liver and kidney damage, significant hematopoietic disorders – aplastic anemia, and others). It is believed that 0.5-5% of patients require hospital treatment for adverse drug reactions.

	Before prescribing a drug to a patient, the doctor evaluates the possible risk (columns “Contraindications”, “Side Effects”, “Precautions” in the instructions or manuals) and makes sure that the drug will not harm the patient’s health.

oral ) is first exposed to the gastrointestinal tract. In such cases, side effects may be tooth enamel destruction, stomatitis, gastrointestinal disorders – irritation of the mucous membrane, nausea, a feeling of bloating, loss of appetite, constipation or diarrhea, indigestion, and so on. These reactions usually resolve quickly after discontinuation of the drug. A number of drugs can stimulate the release of hydrochloric acid, slow down the production of protective mucus or the processes of natural renewal of the mucous membrane, which creates the preconditions for the formation of ulcers. This effect is called ulcerogenic (from English ulcer – ulcer), hormones of the adrenal cortex from the group of corticosteroids ( glucocorticoids ), analgesics, drugs with pronounced anti-inflammatory activity and exerting, in addition , analgesic and antipyretic action ( non-steroidal anti-inflammatory drugs ), reserpine , tetracycline , caffeine and others.

Relatively often the liver and kidneys are affected by medication. Why? The liver is a barrier between the intestinal vessels and the general circulatory system. When taken orally, all drugs pass through the liver before entering the general circulation. It is she who takes the first blow and it is in her that most drugs accumulate and undergo biotransformation. Moreover, the longer the drug is retained in the liver, the higher the likelihood of a violation of its functions and structure. Liver complications often occur with the use of halogen-containing drugs ( chlorpromazine , chloral hydrate , halothane and others), preparations of arsenic, mercury, some antibiotics ( tetracycline , streptomycin ) and so on.

The kidneys are the excretory organ. Through them, many medicinal substances are excreted from the body – unchanged or after a series of transformations. The accumulation of these substances in the kidneys is a prerequisite for the manifestation of a toxic effect on this organ ( nephrotoxicity ). Antibiotics streptomycin , gentamicin , neomycin and other representatives of aminoglycosides, butadione , sulfanilamide preparations 9 have this effect 0135, vasoconstrictors and others.

The side effect of drugs can be manifested in the violation of some functions of the nervous system. Nerve cells are particularly sensitive to chemicals, so drugs that cross the barrier that separates the central nervous system from the blood (called hematoencephalic ), may cause headache, dizziness, lethargy, and impaired performance. Long-term use of certain drugs is dangerous with more serious complications. Thus, drugs that have an inhibitory effect on the central nervous system ( neuroleptics ) can cause the development of depression and parkinsonism, and drugs that reduce the feeling of fear and tension ( tranquilizers , or anxiolytics ) – disrupt gait, stimulants – cause prolonged insomnia, and so on. The aminoglycoside antibiotics mentioned above ( streptomycin , gentamicin , neomycin and others) sometimes affect hearing and the vestibular apparatus.

The advent of broad-spectrum antibiotics has also given rise to a number of complications associated with their use. First, antibiotics cause the death and decay of the microbes that caused the disease, which increases the flow of toxins into the blood – poisons produced by these microbes. This sharply exacerbates all the symptoms of the disease and requires additional therapy to neutralize toxins. Secondly, antibiotics do not always make out who is an enemy and who is a friend, and together with pathogens they infect microorganisms that are “friendly” to a person, which make up his natural microflora. As a result, the ratio and composition of microorganisms coexisting in the gastrointestinal tract changes ( dysbacteriosis ). The protection of the body is sharply weakened, and under these conditions, previously “dormant” microbes, whose activity was suppressed by the natural microflora, can begin to multiply. The most common is candidiasis (it is caused by a fungus of the genus Candida). It affects the mucous membranes and skin, which have lost their natural protection. To prevent this complication, antibiotics are combined with antifungal agents. Against the background of dysbacteriosis, more serious additional infections can occur, which most often affect the respiratory tract and especially the digestive organs.

One of the most dangerous complications from the use of drugs is the suppression of hematopoiesis – anemia (in most forms of which there is a decrease in the number of erythrocytes – red blood cells) or leukopenia (a decrease in the number of leukocytes – white blood cells th bodies). Some antibiotics (e.g. chloramphenicol ), nonsteroidal anti-inflammatory drugs ( indomethacin , phenylbutazone and others), anti-tuberculosis drugs and others. The destruction of blood cells is sometimes due to allergic reactions, the cause of which may be the use of, for example, methyldopa , Analgin , quinidine and others.

A common complication of drug therapy is hypersensitivity reactions to the drug ( allergic reactions ). A medicine is a substance alien to the body ( antigen ), therefore, at the first contact with it or its complex with a protein, blood proteins ( antibodies ) can be formed, which protect the body from the “stranger”. With subsequent administration, such an antigen drug interacts with antibodies, and an allergic reaction develops, which can manifest itself as a skin rash, itching, swelling, and other, sometimes more dangerous, symptoms. The strongest allergenic substances ( allergens ), among the drugs are penicillin antibiotics , sulfanilamide drugs , local anesthetics ( local anesthetics ), prophylactic or curative drugs, obtained from killed or weakened cultures of microorganisms, their toxins or antigens ( vaccines ), analgesics.

Some drugs may cause photosensitivity in a patient – increased sensitivity of the body to the action of solar (ultraviolet) radiation, usually manifested by inflammation of exposed areas of the skin and mucous membranes. This is manifested by a sensation of itching, burning, swelling and redness of the affected area of the skin. Photosensitizing drugs can cause premature skin aging, as well as eye burns, decreased immunity, allergic reactions, and, in rare cases, skin cancer (melanoma) in susceptible patients. Patients who are forced to take drugs that cause photosensitivity (such information is indicated on the package or in the instructions for the drug), while taking them, should avoid visiting tanning beds, physiotherapy (ultraviolet lamps), exposure to direct sunlight and use sunscreen (glasses, lotions and creams for exposed skin, and so on).

	During treatment with drugs that have photosensitizing properties, it is necessary to avoid visits to solariums, physiotherapy procedures (UVI), exposure to direct sunlight. It is advisable to use sunscreen.

therapeutic doses). Doses exceeding therapeutic doses cause toxic effects. Overdose of is a serious problem, especially with drugs where the maximum tolerated dose is not much higher than the therapeutic dose. The risk of overdose is often the reason why doctors prefer one drug over another when the effectiveness of both is close. For example, benzodiazepines ( medazepam , diazepam ) are usually prescribed as sedatives or hypnotics, and not barbiturates . The reason for this is simple – benzodiazepines are safer in case of accidental or intentional overdose. Better safety inherent in new type 9 antidepressants0132 fluoxetine or paroxetine , which are gradually replacing imipramine or amitriptyline .

“Choose the lesser of two evils.” This well-known phrase applies to pharmacology as well. Let’s compare the degree of danger in case of an overdose of amitriptyline and fluoxetine. In the “Overdose” column, amitriptyline lists “hallucinations, convulsions, delirium, coma, cardiac conduction disturbance, extrasystole, ventricular arrhythmias, hypothermia, and others.” With an overdose of fluoxetine, “nausea, vomiting, excitation of the central nervous system, convulsions” occur.

Overdose may be related to the characteristics of the body’s effect on the drug ( pharmacokinetics ) in a particular patient. For example, the accumulation of a drug in toxic concentrations (although a therapeutic dose was taken) is possible as a result of a violation of its biotransformation or delayed excretion. This happens in diseases of the liver and kidneys, especially in old age. Therefore, in such patients, doctors reduce the dose or frequency of taking the medication.

	Exact observance of the doctor’s prescriptions and the requirements of the instructions for the use of the drug, taking medications at the appointed time in many cases can avoid complications. However, if side effects still occur, you should immediately consult a doctor for advice.

Your doctor may reduce your dose, change the frequency of your medication, or replace it with a different one. All this will minimize unwanted effects. Of course, the selection of the necessary drug in a safe dosage is carried out by the doctor, but the final decision whether to take the drug or not remains with the patient (chapter 2.1).

Literature

Belousov Yu.B., Moiseev V.S., Lepakhin V.K. Clinical pharmacology and pharmacotherapy: A guide for physicians. – M.: Universum, 1993. – 398 p.
Goryachkina L.

Aleve d side effects: Aleve-D Sinus & Cold Uses, Side Effects & Warnings

Aleve-D Sinus & Cold Tablet – Product

Overview

Uses

Side-effects

Precautions

Interactions with Aleve-D Sinus & Cold Tablet

When not to use Aleve-D Sinus & Cold Tablet

Composition and Active Ingredients

Packages and Strengths

Frequently asked Questions

Cite this page

Page URL

HTML Link

APA Style Citation

MLA Style Citation

Chicago Style Citation

More about Aleve-D Sinus & Cold Tablet

Last updated date

Pain

Fever

Paget’s Disease of Bone

Bartter’s Syndrome

Aleve (Naproxen) Side Effects

How we reviewed this article:

Read this next

Ryazan State Medical University named after Academician I.P. Pavlov

Admission Campaign – 2023

TELL YOU WHO IS ALREADY AVAILABLE ONLINE PAYMENT FOR TRAINING IN RYAZGMU

“PSYCHOLOGY AND MEDICINE-2023: INTERNATIONAL CONFERENCE OF STUDENTS AND YOUNG SCIENTISTS

Register of medicines of Russia RLS Patient 2003.

Literature

Leave a Reply Cancel reply