What are the primary uses of Aleve-D Sinus & Cold. What are the most common side effects of this medication. How should patients use Aleve-D Sinus & Cold safely. What precautions should be taken when using this sinus and cold remedy.

Understanding Aleve-D Sinus & Cold: Composition and Mechanism of Action

Aleve-D Sinus & Cold Tablet is a combination medication designed to provide relief from sinus congestion, pain, and fever. This over-the-counter remedy contains two active ingredients: Naproxen Sodium and Pseudoephedrine Hydrochloride. Each component plays a specific role in addressing various symptoms associated with sinus and cold discomfort.

How does Aleve-D Sinus & Cold work? The medication operates through two primary mechanisms:

• Naproxen Sodium blocks cyclooxygenase, an enzyme responsible for prostaglandin synthesis. By inhibiting this process, it helps reduce inflammation, pain, and fever.
• Pseudoephedrine Hydrochloride acts as a decongestant by narrowing blood vessels in the nasal passages, thereby decreasing swelling and congestion.

This dual-action approach makes Aleve-D Sinus & Cold an effective choice for those seeking comprehensive relief from multiple cold and sinus symptoms.

Primary Uses and Benefits of Aleve-D Sinus & Cold

Aleve-D Sinus & Cold Tablet is prescribed for various conditions related to sinus and cold symptoms. Its primary uses include:

1. Sinus congestion relief
2. Pain management
3. Fever reduction
4. Nasal congestion alleviation

In addition to these common applications, healthcare providers may recommend Aleve-D Sinus & Cold for other conditions such as:

• Osteitis deformans (Paget’s disease of bone)
• Bartter’s syndrome

Is Aleve-D Sinus & Cold effective for all types of pain? While the medication is primarily designed for pain associated with sinus and cold symptoms, its pain-relieving properties may extend to other types of discomfort. However, it’s crucial to consult with a healthcare professional before using this medication for conditions other than those listed on the label.

Potential Side Effects: What Users Should Know

As with any medication, Aleve-D Sinus & Cold can cause side effects. While not everyone experiences adverse reactions, it’s essential to be aware of potential issues that may arise. Common side effects include:

• Gastrointestinal discomfort (constipation, heartburn, abdominal pain, nausea)
• Drowsiness and dizziness
• Headache
• Sweating
• Nervousness and irritability
• Insomnia

Can Aleve-D Sinus & Cold cause more severe side effects? In some cases, users may experience more serious adverse reactions, such as:

• Easy bruising or bleeding
• Fever, chills, or flu-like symptoms
• High blood pressure
• Mental depression
• Fast or uneven heartbeat

If you notice any of these symptoms or other unusual changes in your health while taking Aleve-D Sinus & Cold, it’s crucial to seek medical attention promptly.

Safety Precautions and Important Counseling Points

Before using Aleve-D Sinus & Cold, it’s essential to consider several safety precautions and discuss any concerns with your healthcare provider. Key points to remember include:

• Inform your doctor about all current medications, including over-the-counter products and supplements
• Disclose any allergies or pre-existing health conditions
• Follow dosage instructions carefully, based on your specific condition
• Avoid driving or operating machinery, as the medication may cause drowsiness
• Limit alcohol consumption while using this product
• Take the medication with a full glass of water to minimize gastrointestinal side effects

Should pregnant or breastfeeding women use Aleve-D Sinus & Cold? It’s generally advisable for pregnant women to avoid using this medication, particularly Naproxen Sodium. Breastfeeding mothers should also consult their healthcare provider before using Aleve-D Sinus & Cold, as both active ingredients may pose risks to the infant.

Drug Interactions: Medications to Avoid

Aleve-D Sinus & Cold may interact with various medications, potentially altering their effectiveness or increasing the risk of side effects. Some drugs that may interact with this product include:

• Antidepressants (e.g., Amitriptyline, Doxepin)
• Beta-blockers (e.g., Atenolol, Carvedilol)
• Diuretics (e.g., Furosemide)
• Anticoagulants (e.g., Warfarin)
• Lithium
• Probenecid

Why is it crucial to inform your doctor about all medications you’re taking? By providing a comprehensive list of your current medications, your healthcare provider can assess potential interactions and adjust your treatment plan accordingly, ensuring both safety and efficacy.

Contraindications: When to Avoid Aleve-D Sinus & Cold

Certain conditions and factors may make the use of Aleve-D Sinus & Cold inadvisable. The medication should not be used in the following situations:

• Hypersensitivity to any of the ingredients
• Children under 4 years of age
• Concurrent use of monoamine oxidase inhibitors (MAOIs)
• History of asthma or urticaria triggered by aspirin or other NSAIDs

Are there any other circumstances where Aleve-D Sinus & Cold should be avoided? Patients with a history of gastrointestinal bleeding, heart disease, or kidney problems should consult their healthcare provider before using this medication, as it may exacerbate these conditions.

Dosage and Administration Guidelines

Aleve-D Sinus & Cold is available in tablet form, with each tablet containing 200mg of Naproxen Sodium and 120mg of Pseudoephedrine Hydrochloride. The appropriate dosage may vary depending on the individual’s age, weight, and specific condition being treated.

How should adults take Aleve-D Sinus & Cold? Generally, the recommended dosage for adults is:

• Initial dose: 2 tablets with water
• Subsequent doses: 1 tablet every 8-12 hours as needed
• Maximum daily dose: 3 tablets in 24 hours

It’s crucial to follow the instructions provided by your healthcare provider or the product label. Do not exceed the recommended dosage, as this may increase the risk of side effects without providing additional therapeutic benefits.

Special Considerations for Certain Populations

Elderly patients and those with certain health conditions may require dosage adjustments. It’s essential to consult with a healthcare provider to determine the most appropriate dosing regimen based on individual factors such as:

• Age
• Weight
• Kidney function
• Liver function
• Concurrent medications

Why is it important to adhere to the recommended dosage? Taking more than the prescribed amount of Aleve-D Sinus & Cold can increase the risk of adverse effects, including gastrointestinal bleeding and cardiovascular complications. Conversely, taking less than recommended may result in inadequate symptom relief.

Long-term Use and Potential Risks

While Aleve-D Sinus & Cold can be effective for short-term relief of sinus and cold symptoms, prolonged use may lead to certain risks and complications. It’s important to be aware of these potential issues, especially if you find yourself relying on the medication frequently.

What are the risks associated with long-term use of Aleve-D Sinus & Cold? Some potential concerns include:

• Increased risk of gastrointestinal ulcers and bleeding
• Elevated blood pressure
• Kidney function impairment
• Cardiovascular events, particularly in patients with pre-existing heart conditions
• Rebound congestion (worsening of nasal congestion when the medication is stopped)

To minimize these risks, it’s advisable to use Aleve-D Sinus & Cold only as directed and for the shortest duration necessary to alleviate symptoms. If you find that you need to use the medication for an extended period, consult your healthcare provider to explore alternative treatment options or to discuss the potential benefits and risks of continued use.

Monitoring for Adverse Effects

When using Aleve-D Sinus & Cold, especially for longer periods, it’s crucial to be vigilant for signs of adverse effects. Pay attention to the following symptoms and report them to your healthcare provider promptly:

• Persistent or severe abdominal pain
• Black, tarry stools or blood in the stool
• Chest pain or difficulty breathing
• Unusual weight gain or swelling
• Changes in urination patterns
• Severe headache or dizziness
• Skin rashes or allergic reactions

Regular check-ups with your healthcare provider can help monitor for potential complications and ensure that the benefits of using Aleve-D Sinus & Cold continue to outweigh any risks.

Alternative Treatment Options for Sinus and Cold Relief

While Aleve-D Sinus & Cold can be an effective option for managing sinus and cold symptoms, it’s not the only treatment available. Depending on your specific symptoms and health status, your healthcare provider may recommend alternative approaches or complementary therapies.

What are some alternative treatments for sinus and cold symptoms? Consider the following options:

• Saline nasal irrigation to flush out congestion
• Steam inhalation to relieve nasal and sinus congestion
• Over-the-counter antihistamines for allergy-related congestion
• Acetaminophen for fever and pain relief
• Hydration and rest to support the body’s natural healing processes
• Humidifiers to add moisture to the air and ease congestion
• Herbal remedies such as echinacea or elderberry (consult with a healthcare provider before use)

In some cases, a combination of these approaches may provide more comprehensive relief than relying solely on medication. Discuss these options with your healthcare provider to determine the most appropriate treatment plan for your individual needs.

When to Seek Medical Attention

While many sinus and cold symptoms can be managed at home with over-the-counter medications like Aleve-D Sinus & Cold, certain situations may require professional medical attention. Be aware of the following warning signs that indicate a need for medical evaluation:

• Fever above 101.3°F (38.5°C) that persists for more than three days
• Severe headache or facial pain
• Thick, green, or bloody nasal discharge
• Symptoms that worsen or last longer than 10 days
• Difficulty breathing or shortness of breath
• Severe sore throat or swollen glands
• Persistent cough or chest congestion

Prompt medical attention in these situations can help prevent complications and ensure appropriate treatment for potentially serious conditions.

Aleve-D Sinus & Cold Tablet – Product

Aleve-D Sinus & Cold Tablet – Product – TabletWise

About

•  About Us
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TabletWise

• Overview
• Uses
• Side-effects
• Precautions
• Interactions
• Contraindications

Overview

Aleve-D Sinus & Cold Tablet is used for Sinus congestion, Pain, Fever, Osteitis deformans, Bartter’s syndrome, Nasal congestion and other conditions. Aleve-D Sinus & Cold Tablet may also be used for purposes not listed in this medication guide.

Aleve-D Sinus & Cold Tablet contains Naproxen Sodium and Pseudoephedrine Hydrochloride as active ingredients.

Aleve-D Sinus & Cold Tablet works by blocking cyclooxygenase to prevent prostaglandins synthesis; narrowing the blood vessels to decrease swelling and congestion;

Detailed information related to Aleve-D Sinus & Cold Tablet’s uses, composition, dosage, side effects and reviews is listed below.

Uses

Aleve-D Sinus & Cold Tablet is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:

• Sinus congestion
• Pain
• Fever
• Osteitis deformans
• Bartter’s syndrome
• Nasal congestion
• Aleve-D Sinus & Cold Tablet may also be used for purposes not listed here.

Learn more: Uses

Side-effects

The following is a list of possible side-effects that may occur from all constituting ingredients of Aleve-D Sinus & Cold Tablet. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.

• Constipation
• Heartburn
• Abdominal pain
• Nausea
• Drowsiness
• Headache
• Dizziness
• Sweating
• Diarrhea
• Mental depression
• Nervousness
• Irritability
• Fatigue
• Malaise
• Insomnia
• Fast or uneven heartbeat
• Easy bruising
• Weakness
• Fever
• Chills
• Body ache
• Flu symptoms
• High blood pressure
• Aleve-D Sinus & Cold Tablet may also cause side-effects not listed here.

If you notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority.

Precautions

Before using Aleve-D Sinus & Cold Tablet, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side-effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.

• Do not drive or operate machinery
• Limit alcoholic beverages
• Pregnant, planning to get pregnant or breastfeeding
• Take this medicine with a full glass of water
• do not drive or operate machinery

Interactions with Aleve-D Sinus & Cold Tablet

If you use other drugs or over the counter products at the same time, the effects of Aleve-D Sinus & Cold Tablet may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Aleve-D Sinus & Cold Tablet may interact with the following drugs and products:

• Amitriptyline
• Atenolol
• Carvedilol
• Cimetidine
• Doxepin
• Furosemide
• Lithium
• Probenecid
• Warfarin

When not to use Aleve-D Sinus & Cold Tablet

Hypersensitivity to Aleve-D Sinus & Cold Tablet is a contraindication. In addition, Aleve-D Sinus & Cold Tablet should not be used if you have the following conditions:

• Children under the age of 4 years
• Hypersensitivity
• Monoamine oxidase inhibitors
• asthma
• hypersensitivity
• urticaria

Composition and Active Ingredients

Packages and Strengths

Aleve-D Sinus & Cold Tablet is available in the following packages and strengths

Aleve-D Sinus & Cold Tablet – Packages: 200MG, 120MG

Frequently asked Questions

• Is Aleve-D Sinus & Cold Tablet safe to use when pregnant?

  • Naproxen Sodium: No
  • Pseudoephedrine Hydrochloride: Please consult with your doctor for case-specific recommendations.

• Is Aleve-D Sinus & Cold Tablet safe while breastfeeding?

  • Naproxen Sodium: No
  • Pseudoephedrine Hydrochloride: No

• Can Aleve-D Sinus & Cold Tablet be used for sinus congestion and pain?

  Yes, sinus congestion and pain are among the most common reported uses for Aleve-D Sinus & Cold Tablet. Please do not use Aleve-D Sinus & Cold Tablet for sinus congestion and pain without consulting first with your doctor. Click here and view survey results to find out what other patients report as common uses for Aleve-D Sinus & Cold Tablet.

• Should I use Aleve-D Sinus & Cold Tablet empty stomach, before food or after food?

  TabletWise.com website users have most commonly reported using Aleve-D Sinus & Cold Tablet after food. However, this may not be reflective of how you should use this medicine. Please follow your doctor’s advice on how you should use this medicine. Click here and view survey results to find out what other patients report as timing of using Aleve-D Sinus & Cold Tablet.

• Is it safe to drive or operate heavy machinery when using this product?

  If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Aleve-D Sinus & Cold Tablet medicine then it may not be safe to drive a vehicle or operate heavy machinery. One should not drive a vehicle if using the medicine makes you drowsy, dizzy or lowers your blood-pressure extensively. Pharmacists also advise patients not to drink alcohol with medicines as alcohol intensifies drowsiness side-effects. Please check for these effects on your body when using Aleve-D Sinus & Cold Tablet. Always consult with your doctor for recommendations specific to your body and health conditions.

• Is this medicine or product addictive or habit forming?

  Most medicines don’t come with a potential for addiction or abuse. Usually, the government’s categorizes medicines that can be addictive as controlled substances. Examples include schedule H or X in India and schedule II-V in the US. Please consult the product package to make sure that the medicine does not belong to such special categorizations of medicines. Lastly, do not self-medicate and increase your body’s dependence to medicines without the advice of a doctor.

• Can i stop using this product immediately or do I have to slowly wean off the use?

  Some medicines need to be tapered or cannot be stopped immediately because of rebound effects. Please consult with your doctor for recommendations specific to your body, health and other medications that you may be using.

Cite this page

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APA Style Citation

• Aleve-D Sinus & Cold Tablet – Product – tabletwise.net. (n.d.). Retrieved April 14, 2023, from https://www. tabletwise.net/us/aleve-d-sinus-and-cold-tablet

MLA Style Citation

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Chicago Style Citation

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More about Aleve-D Sinus & Cold Tablet

• Uses
• Reviews

• What are the uses of Aleve-D Sinus & Cold Tablet?
• What are the side-effects of Aleve-D Sinus & Cold Tablet?
• What other medicines does Aleve-D Sinus & Cold Tablet interact with?
• When should you not use Aleve-D Sinus & Cold Tablet?
• What precautions should you take while using Aleve-D Sinus & Cold Tablet?

Last updated date

This page was last updated on 9/27/2020.

This page provides information for Aleve-D Sinus & Cold Tablet Product in English.

• Pain

  Pain is a feeling triggered in the nervous system. Pain may be …

• Fever

  A fever is a body temperature that is higher than normal. It is …

• Paget’s Disease of Bone

  Paget’s disease of bone causes your bones to grow too large and …

• Bartter’s Syndrome

  A rare inherited syndrome characterized by juxtaglomerular cell …

Learn More

Pain

Pain is a feeling triggered in the nervous system. Pain may be …

Fever

A fever is a body temperature that is higher than normal. It is …

Paget’s Disease of Bone

Paget’s disease of bone causes your bones to grow too large and …

Bartter’s Syndrome

A rare inherited syndrome characterized by juxtaglomerular cell …

Pain

Fever

Paget’s Disease of Bone

Bartter’s Syndrome

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Aleve (Naproxen) Side Effects

Aleve (Naproxen) Side Effects

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Medically reviewed by Alan Carter, Pharm. D. — By University of Illinois — Updated on May 18, 2017

Overview

Aleve is one brand of the over-the-counter drug naproxen sodium 220 milligrams (mg). It treats many types of mild pain. You may have taken it to treat your headaches, menstrual cramps, arthritis, muscles aches, toothaches, backaches, and even mild fever. If you take Aleve, though, you may wonder what else it does in your body.

Although Aleve can bring relief, it can also cause side effects. Some of these side effects can happen just from short-term use. Long-term use of Aleve can also cause other side effects. Some people are at greater risk of Aleve side effects because of certain medical conditions that they have.

Here’s what to know about how Aleve works and the side effects it can cause.

Aleve, or naproxen sodium 220 mg, is the over-the-counter version of naproxen sodium 275 mg, which is available by prescription only. Aleve is closely related to naproxen base 250 mg, also prescription only.

Both Aleve and its prescription counterparts belong to a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). These drugs reduce pain and fever by preventing your body from making prostaglandins. Prostaglandins are substances your body produces when tissues of your body are injured. These substances contribute to many of the effects of inflammation, including swelling, fever, and pain.

Inhibiting your body’s production of prostaglandins can help prevent pain and other effects related to inflammation. But it can also interfere with some other functions.

Prostaglandins naturally help protect your stomach from damage. When Aleve reduces your prostaglandin production, it can cause:

• stomach pain
• constipation
• diarrhea
• gas
• heartburn
• nausea or vomiting

These effects are more likely the older you are or the longer you use Aleve.

More serious side effects include:

• swelling
• bleeding
• ulcers
• tears in your stomach, small intestine, or large intestine

These effects can be fatal and can happen without warning. If you notice severe stomach pain or bloody or black, tarry stools while you take Aleve, stop taking the drug and call your doctor right away. To lower your risk of digestive system side effects, use the lowest effective dosage for the shortest time.

Aleve can also increase your blood pressure. You might not notice any signs that your blood pressure is increased. And if you already have high blood pressure, taking Aleve might make it worse. You should talk to your doctor before using Aleve if you have high blood pressure.

Aleve can also reduce your blood’s ability to clot. This can lead to bleeding. Talk to your doctor before using Aleve if you plan on having surgery soon.

Long-term use of Aleve can make your heart work harder. Aleve makes you retain water, which increases the load on your heart. This extra work can cause pressure on your cardiovascular system and can sometimes lead to a heart attack or stroke. These risks are even greater at higher dosages, even if you don’t have any heart conditions or risk of heart disease. Call 911 or local emergency services if you have:

• chest pain
• shortness of breath
• slurred speech
• weakness in your arms or legs

These are signs of a stroke or heart attack. If you take Aleve and have unexplained weight gain or swelling, especially in your legs and feet, talk to your doctor right away. These may be signs of heart failure. To lower your risk of heart problems, use the lowest dosage for the shortest amount of time.

Prostaglandins maintain the pressure in your kidneys so that these organs can filter the fluids in your body. A decrease in your level of prostaglandins from taking Aleve can cause problems with your kidney function. You may notice fluid retention or changes in how much you urinate. If you notice these changes while taking Aleve, stop taking it and contact your doctor.

People with certain medical conditions may experience more side effects from Aleve than other people. These conditions include:

• history of stomach ulcers or stomach bleeding
• kidney disease
• heart disease
• liver disease

If you have any of these conditions, talk to your doctor before using Aleve. Your doctor may suggest another medication to avoid complications.

For most people, Aleve is an effective treatment for mild pain and fever, especially for short-term use. Side effects can occur, but for the most part the effects are mild. Typically, more severe side effects are associated with extended use. But, as with any medication, if you have a medical condition, take other drugs, or simply aren’t sure if you should take it, talk to your doctor.

Last medically reviewed on May 16, 2017

How we reviewed this article:

Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

• Grosser T, et al. (2011). Chapter 34: Anti-inflammatory, antipyretic, and analgesic agents; pharmacotherapy of gout. The pharmacological basis of therapeutics, 12th edition.
  accessbiomedicalscience.mhmedical.com/content.aspx?sectionid=102161048&bookid=1613
• Label: Naprosyn – naproxen tablet; EC-naprosyn – naproxen tablet, delayed release; Naprosyn – naproxen suspension; Anaprox – naproxen sodium tablet; Anaprox DS – naproxen sodium tablet. (2016).
  dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=68848217-03c9-4377-9be6-6f567e629129
• Naproxen. (2015).
  nlm.nih.gov/medlineplus/druginfo/meds/a681029.html
• Risser A, et al. (2009). NSAID prescribing precautions.
  aafp.org/afp/2009/1215/p1371.html

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Medically reviewed by Alan Carter, Pharm.D. — By University of Illinois — Updated on May 18, 2017

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On the official website in the section “Applicants / Applicants (specialist / bachelor’s / master’s) / Progress of the admission campaign” there are lists of applicants who have submitted documents, indicating the points awarded for individual achievements.

07/17/2023

LIPETSK EMERGENCY HOSPITAL AND RYAZGMU COMBINE TO CREATE A CENTER FOR ADDITIONAL EDUCATION
On July 14, RyazGMU Rector Roman Kalinin and Chief Physician of the Lipetsk City Emergency Hospital N1 Dmitry Pavlyukevich signed a cooperation agreement.

07/14/2023

New clinical base of Ryazan State Medical University
A cooperation agreement was signed with the Neuroclinic Center, a medical and pedagogical institution in the city of Ryazan.

07/14/2023

EP candidates for the City Duma
The rector of the Ryazan State Medical University, Professor Kalinin Roman Evgenievich, was included in the list of candidates for deputies of the Ryazan City Representative Assembly.

07/13/2023

Participate in the action “Welcome to the village”
Medical volunteers of the Ryazan State Medical University as part of a team of specialists from the Center for Public Health work in small towns of the Ryazan region.

07/13/2023

SCIENTIFIC TOURISM
The initiative is aimed at attracting young people to unique and exciting complex tours in Russia.

07/13/2023

“Give me life!”
University students took an active part in the All-Russian action with the same name.

News

14.02.2023

TELL YOU WHO IS ALREADY AVAILABLE ONLINE PAYMENT FOR TRAINING IN RYAZGMU

Now all students of the FDPO RyazGMU can pay for training without leaving their homes. You can pay online and without commission using the new service pay.rzgmu.ru

09/23/2022

News FDPO RyazGMU

04/04/2023

Course “PSYCHOLOGICAL METHODS OF WORK WITH THE CONSEQUENCES OF PSYCHOTRAUFUL EVENTS”
Additional professional advanced training program “Psychological methods of working with the consequences of traumatic events” was developed for specialists with a psychological education.

02/28/2023

SWIMMING IN THE MEDICAL SENSE IS USEFUL FOR ABSOLUTELY EVERYONE
Why – says Valery Grigorievich Demikhov, Doctor of Medical Sciences, Professor, Director of the Scientific and Clinical Center for Hematology, Oncology and Immunology, Ryazan State Medical University of the Ministry of Health of Russia

22.02.2023

DEPARTURE TO THE NOVOMOSKOVSK CITY CLINICAL HOSPITAL
On February 16, a visit to the State Healthcare Institution “Novomoskovsk City Clinical Hospital” took place. On behalf of the Ministry of Health of the Tula region, tests were prepared to assess the knowledge of obstetrician-gynecologists. Head of the Department of Obstetrics and Gynecology of the Ryazan State Medical University Kovalenko M.S. and Dean of the FDPO RyazGMU Maksimtseva E.A. tested 21 specialists of the State Healthcare Institution “NGCH” and conducted a clinical tour of the departments of branch No. 2 of the State Health Institution “NGCH” together with the Deputy Chief Physician for Obstetrics and Gynecology Breus E.V. and department staff.

22.02.2023

TRAINING UNDER THE PROGRAM “NURSING IN PEDIATRICS” IS COMPLETED
On February 16, the 144-hour advanced training program “Nursing in Pediatrics” ended. During the training, nurses in the Ryazan region improved their knowledge and skills in nursing care for a healthy and sick child with infectious and somatic pathology, prevention of somatic and infectious pathology in childhood in accordance with the regulatory framework, professional standards and clinical recommendations.

02/16/2023

WetLab

02/14/2023

BASIC EMERGENCY FIRST AID COURSE

02/14/2023

COURSE “METHODS OF NON-TEST PSYCHODIAGNOSIS OF PERSONALITY”

27.09.2022

Russian as a foreign language (speech practice course)

FDPO

07/19/2023

“PSYCHOLOGY AND MEDICINE-2023: INTERNATIONAL CONFERENCE OF STUDENTS AND YOUNG SCIENTISTS

On November 23-24, 2023, the anniversary X International Conference of Students and Young Scientists “Psychology and Medicine: Ways to Find Optimal Interaction – 2023” “Health and Psychological Well-Being of the Personality” will be held.

06/20/2023

INTESTINAL OBSTRUCTION IN CHILDREN OVER THE NEWBORN PERIOD
Dear Colleagues! We invite you to the scientific and educational school “Intestinal obstruction in children older than the neonatal period”, which will be held on June 23, 2023. The event will discuss topical issues of diagnosis, treatment and tactics of the surgeon in intestinal obstruction in children.

06/20/2023

SCIENTIFIC AND PRACTICAL CONFERENCE
High-profile specialists in the field of neonatology and obstetrics will make presentations on June 23, 2023 at the Ryazan State Medical University.

06/15/2023

Learning to write dissertations
The Council of Young Scientists of the Ryazan State Medical University will hold a meeting for graduate students, applicants and young scientists with Doctor of Medical Sciences Professor Elena Nikolaevna Yakusheva

09. 06.2023

Conference of psychologists
We invite you to take part in the student scientific and practical conference “Formation of professional research competence of future clinical psychologists”

06/02/2023

I Congress of Therapists of the Central Federal District
8-9June at the Ryazan State Medical University will host a forum focused on practical healthcare professionals. The organizers are RNMOT, the Ministry of Health of the Ryazan Region and the Ryazan State Medical University.

06/02/2023

In June, the second cycle of training “Fundamentals of Kinesiology Taping” starts
The cycle is intended for everyone, regardless of the presence or absence of a medical education. Listeners have the opportunity to get or improve the skill of using elastic bands, to learn everything or almost everything about teips!

29.05.2023

Physical and Rehabilitation Medicine in Pediatrics
On June 3, 2023, the University will host the Interregional Scientific and Practical Conference “Physical and Rehabilitation Medicine in Pediatrics”. Beginning at 10.00 in the hall of the Academic Council, at the address: Ryazan, st. Vysokovoltnaya, d. 7, bldg. 1, 4th floor.

05/25/2023

Mental health service: achievements and prospects
We invite you to take part in the IX Interregional Scientific and Practical Conference “Mental Health Service: Achievements and Prospects. Dedicated to the 135th anniversary of the Ryazan Regional Clinical Psychiatric Hospital. N.N. Bazhenov”, which will be held on June 2, 2023 on the basis of the Ryazan Regional Clinical Psychiatric Hospital. Bazhenova N.N.

05/22/2023

WE INVITE YOU TO READ THE PROGRAM OF THE CONFERENCE “TOPICAL ISSUES OF THERAPY AND GENERAL MEDICAL PRACTICE”

Announcements

Register of medicines of Russia RLS Patient 2003.

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Undesirable drug effects and their causes. Side effects, allergic reactions to the drug, overdose. How to avoid drug side effects?

Everyone who has ever taken a medicine knows that it can not only treat a disease, but also have side effects. And even if the doctor does not warn about the presence of side effects in the drug, then in the leaflet to the drug, a separate line lists all those undesirable effects that may occur during treatment with this drug. What is it, side effect ? And is it possible to do without it?

Chapter 2.5 states that the effect of most drugs is based on their physicochemical or chemical interaction with cell membrane receptors. As a result of this, certain changes occur in all cells that have receptors that “recognize” this drug. Their summation leads to a change in the functions of a tissue, organ or organ system, which is the purpose of the drug, that is, its therapeutic effect. For example, blood pressure decreases, pain subsides, swelling decreases, and so on. But the matter is not limited to the therapeutic effect. A drug with exceptional selectivity is an ideal, a “magic bullet”, precisely aimed at a sore spot and not touching healthy tissues. In real life, the action of most drugs resembles a multi-colored mosaic. This is due to several reasons. First, the administered medicine does not only get to the right place. In the body, it is carried by the blood to all tissues and meets with components of cell membranes ( receptors ) capable of interacting with it. And healthy cells have receptors that can bind to drugs. This leads to a change in their functions, and, therefore, to any pharmacological effect. For example, we lowered the pressure, but diarrhea appeared or the heart rate increased. These effects will no longer be curative, because the patient took this drug for another purpose. Secondly, part of the drug, as we already know from the previous chapters, undergoes transformation under the action of the body’s defense systems ( biotransformation ) and loses its original pharmacological activity, but the resulting substances (metabolites) may have some new biological properties and cause various effects.

Drugs have the main therapeutic effect, which is expected when using the drug in each specific case (for example, analgesics are used to relieve pain, antihypertensive drugs are used to lower blood pressure, and so on). Sometimes there are several such therapeutic effects, and two or three of the most pronounced ones determine both the main pharmacological effect of the drug and the indications for its use.

For example, for preparations containing loratadine as an active substance, the column “pharmacological action” indicates: antiallergic, antipruritic, antiexudative. In sodium bicarbonate , more commonly known as baking soda, the pharmacological action is antacid, expectorant, restoring the alkaline state of the blood – it all depends on the route of administration, dosage form and dose.

Effects that are not directed against the disease, beyond the purpose for which the drug is taken, are called side effects. By definition, side effects drugs are undesirable effects that are part of the spectrum of pharmacological activity of the drug and occur when the drug is used in therapeutic doses (not in cases of overdose).

Lacking sufficient selectivity, drugs affect the functions of many tissues and organs (including those not affected by the disease). Some negative effects of the medicinal product that do not go beyond the resistance zone in terms of intensity or duration of exposure, the body can “neutralize on its own”. In other cases, when the state of the organism as a system has gone beyond the stability zone, a side effect of the drug appears.

Side effects may be primary or secondary. The primary effect occurs as a direct consequence of the influence of this drug on the substrate, for example, when the substance irritates the gastric mucosa, nausea, vomiting, and pain occur. Secondary side effects develop indirectly as a result of taking the drug, for example, hypovitaminosis and dysbacteriosis when the intestinal microflora is suppressed by antibiotics. More on this will be discussed a little later.

For acetylsalicylic acid , which, by the way, refers to over-the-counter drugs, the “Side effect” column in the instructions or in the reference book takes more than one line. “Tinnitus, dizziness, hearing loss, epigastric pain, heartburn, nausea and vomiting, severe bleeding from the gastrointestinal tract, thrombocytopenia, anemia, leukopenia, Reye’s syndrome, hypersensitivity reactions (bronchospasm, laryngeal edema and urticaria), “aspirin” bronchial asthma, interstitial nephritis, acute renal failure … “We will not list all the side effects … ” . However, judge for yourself how balanced the decision to take any drug should be.

nausea, headache, etc. ) and disappear after discontinuation or reduction in the dosage of the drug. However, there are those that can be severe and even life-threatening for the patient (liver and kidney damage, significant hematopoietic disorders – aplastic anemia, and others). It is believed that 0.5-5% of patients require hospital treatment for adverse drug reactions.

oral ) is first exposed to the gastrointestinal tract. In such cases, side effects may be tooth enamel destruction, stomatitis, gastrointestinal disorders – irritation of the mucous membrane, nausea, a feeling of bloating, loss of appetite, constipation or diarrhea, indigestion, and so on. These reactions usually resolve quickly after discontinuation of the drug. A number of drugs can stimulate the release of hydrochloric acid, slow down the production of protective mucus or the processes of natural renewal of the mucous membrane, which creates the preconditions for the formation of ulcers. This effect is called ulcerogenic (from English ulcer – ulcer), hormones of the adrenal cortex from the group of corticosteroids ( glucocorticoids ), analgesics, drugs with pronounced anti-inflammatory activity and exerting, in addition , analgesic and antipyretic action ( non-steroidal anti-inflammatory drugs ), reserpine , tetracycline , caffeine and others.

Relatively often the liver and kidneys are affected by medication. Why? The liver is a barrier between the intestinal vessels and the general circulatory system. When taken orally, all drugs pass through the liver before entering the general circulation. It is she who takes the first blow and it is in her that most drugs accumulate and undergo biotransformation. Moreover, the longer the drug is retained in the liver, the higher the likelihood of a violation of its functions and structure. Liver complications often occur with the use of halogen-containing drugs ( chlorpromazine , chloral hydrate , halothane and others), preparations of arsenic, mercury, some antibiotics ( tetracycline , streptomycin ) and so on.

The kidneys are the excretory organ. Through them, many medicinal substances are excreted from the body – unchanged or after a series of transformations. The accumulation of these substances in the kidneys is a prerequisite for the manifestation of a toxic effect on this organ ( nephrotoxicity ). Antibiotics streptomycin , gentamicin , neomycin and other representatives of aminoglycosides, butadione , sulfanilamide preparations 9 have this effect 0135, vasoconstrictors and others.

The side effect of drugs can be manifested in the violation of some functions of the nervous system. Nerve cells are particularly sensitive to chemicals, so drugs that cross the barrier that separates the central nervous system from the blood (called hematoencephalic ), may cause headache, dizziness, lethargy, and impaired performance. Long-term use of certain drugs is dangerous with more serious complications. Thus, drugs that have an inhibitory effect on the central nervous system ( neuroleptics ) can cause the development of depression and parkinsonism, and drugs that reduce the feeling of fear and tension ( tranquilizers , or anxiolytics ) – disrupt gait, stimulants – cause prolonged insomnia, and so on. The aminoglycoside antibiotics mentioned above ( streptomycin , gentamicin , neomycin and others) sometimes affect hearing and the vestibular apparatus.

The advent of broad-spectrum antibiotics has also given rise to a number of complications associated with their use. First, antibiotics cause the death and decay of the microbes that caused the disease, which increases the flow of toxins into the blood – poisons produced by these microbes. This sharply exacerbates all the symptoms of the disease and requires additional therapy to neutralize toxins. Secondly, antibiotics do not always make out who is an enemy and who is a friend, and together with pathogens they infect microorganisms that are “friendly” to a person, which make up his natural microflora. As a result, the ratio and composition of microorganisms coexisting in the gastrointestinal tract changes ( dysbacteriosis ). The protection of the body is sharply weakened, and under these conditions, previously “dormant” microbes, whose activity was suppressed by the natural microflora, can begin to multiply. The most common is candidiasis (it is caused by a fungus of the genus Candida). It affects the mucous membranes and skin, which have lost their natural protection. To prevent this complication, antibiotics are combined with antifungal agents. Against the background of dysbacteriosis, more serious additional infections can occur, which most often affect the respiratory tract and especially the digestive organs.

One of the most dangerous complications from the use of drugs is the suppression of hematopoiesis – anemia (in most forms of which there is a decrease in the number of erythrocytes – red blood cells) or leukopenia (a decrease in the number of leukocytes – white blood cells th bodies). Some antibiotics (e.g. chloramphenicol ), nonsteroidal anti-inflammatory drugs ( indomethacin , phenylbutazone and others), anti-tuberculosis drugs and others. The destruction of blood cells is sometimes due to allergic reactions, the cause of which may be the use of, for example, methyldopa , Analgin , quinidine and others.

A common complication of drug therapy is hypersensitivity reactions to the drug ( allergic reactions ). A medicine is a substance alien to the body ( antigen ), therefore, at the first contact with it or its complex with a protein, blood proteins ( antibodies ) can be formed, which protect the body from the “stranger”. With subsequent administration, such an antigen drug interacts with antibodies, and an allergic reaction develops, which can manifest itself as a skin rash, itching, swelling, and other, sometimes more dangerous, symptoms. The strongest allergenic substances ( allergens ), among the drugs are penicillin antibiotics , sulfanilamide drugs , local anesthetics ( local anesthetics ), prophylactic or curative drugs, obtained from killed or weakened cultures of microorganisms, their toxins or antigens ( vaccines ), analgesics.

Some drugs may cause photosensitivity in a patient – increased sensitivity of the body to the action of solar (ultraviolet) radiation, usually manifested by inflammation of exposed areas of the skin and mucous membranes. This is manifested by a sensation of itching, burning, swelling and redness of the affected area of ​​the skin. Photosensitizing drugs can cause premature skin aging, as well as eye burns, decreased immunity, allergic reactions, and, in rare cases, skin cancer (melanoma) in susceptible patients. Patients who are forced to take drugs that cause photosensitivity (such information is indicated on the package or in the instructions for the drug), while taking them, should avoid visiting tanning beds, physiotherapy (ultraviolet lamps), exposure to direct sunlight and use sunscreen (glasses, lotions and creams for exposed skin, and so on).

therapeutic doses). Doses exceeding therapeutic doses cause toxic effects. Overdose of is a serious problem, especially with drugs where the maximum tolerated dose is not much higher than the therapeutic dose. The risk of overdose is often the reason why doctors prefer one drug over another when the effectiveness of both is close. For example, benzodiazepines ( medazepam , diazepam ) are usually prescribed as sedatives or hypnotics, and not barbiturates . The reason for this is simple – benzodiazepines are safer in case of accidental or intentional overdose. Better safety inherent in new type 9 antidepressants0132 fluoxetine or paroxetine , which are gradually replacing imipramine or amitriptyline .

“Choose the lesser of two evils.” This well-known phrase applies to pharmacology as well. Let’s compare the degree of danger in case of an overdose of amitriptyline and fluoxetine. In the “Overdose” column, amitriptyline lists “hallucinations, convulsions, delirium, coma, cardiac conduction disturbance, extrasystole, ventricular arrhythmias, hypothermia, and others.” With an overdose of fluoxetine, “nausea, vomiting, excitation of the central nervous system, convulsions” occur.

Overdose may be related to the characteristics of the body’s effect on the drug ( pharmacokinetics ) in a particular patient. For example, the accumulation of a drug in toxic concentrations (although a therapeutic dose was taken) is possible as a result of a violation of its biotransformation or delayed excretion. This happens in diseases of the liver and kidneys, especially in old age. Therefore, in such patients, doctors reduce the dose or frequency of taking the medication.

Your doctor may reduce your dose, change the frequency of your medication, or replace it with a different one. All this will minimize unwanted effects. Of course, the selection of the necessary drug in a safe dosage is carried out by the doctor, but the final decision whether to take the drug or not remains with the patient (chapter 2.1).

Literature

1. Belousov Yu.B., Moiseev V.S., Lepakhin V.K. Clinical pharmacology and pharmacotherapy: A guide for physicians. – M.: Universum, 1993. – 398 p.
2. Goryachkina L.