What are the primary uses of amoxicillin. How should amoxicillin be dosed properly. What are the common side effects of amoxicillin. How does amoxicillin interact with other medications. What precautions should be taken when using amoxicillin.

Understanding Amoxicillin: An Overview of the Antibiotic

Amoxicillin is a widely prescribed antibiotic belonging to the penicillin family. It’s used to treat a variety of bacterial infections by inhibiting the growth of bacteria. This medication is available in various forms, including oral tablets, capsules, and suspension.

Is amoxicillin effective against all types of infections? No, amoxicillin is specifically designed to combat certain bacterial infections. It’s not effective against viral infections such as the common cold or flu.

Key Features of Amoxicillin

• Broad-spectrum antibiotic
• Available in multiple formulations
• Typically well-tolerated
• Requires a prescription

Common Uses and Applications of Amoxicillin

Amoxicillin is prescribed for a wide range of bacterial infections affecting different parts of the body. Healthcare providers often turn to this antibiotic due to its effectiveness and relatively low risk of side effects.

Which infections can amoxicillin treat? Amoxicillin is commonly used to treat:

• Respiratory tract infections (bronchitis, pneumonia)
• Ear infections
• Urinary tract infections
• Skin infections
• Dental infections
• Helicobacter pylori infections (in combination with other medications)

Can amoxicillin be used for preventive purposes? In some cases, amoxicillin may be prescribed prophylactically, such as to prevent bacterial endocarditis in individuals with certain heart conditions undergoing dental procedures.

Proper Dosage and Administration of Amoxicillin

The correct dosage of amoxicillin depends on several factors, including the type and severity of the infection, the patient’s age, weight, and overall health condition. It’s crucial to follow the prescribed dosage and complete the full course of treatment, even if symptoms improve before the medication is finished.

How is amoxicillin typically dosed? For adults, common dosages range from 250 mg to 500 mg every 8 hours or 500 mg to 875 mg every 12 hours, depending on the infection being treated. Pediatric dosages are usually calculated based on the child’s weight.

Important Dosing Considerations

• Take at evenly spaced intervals
• Can be taken with or without food
• Complete the entire prescribed course
• Do not adjust dosage without consulting a healthcare provider

Potential Side Effects and Adverse Reactions

While amoxicillin is generally well-tolerated, like all medications, it can cause side effects. Most side effects are mild and resolve on their own, but some can be more serious and require medical attention.

What are the most common side effects of amoxicillin? The most frequently reported side effects include:

• Nausea and vomiting
• Diarrhea
• Rash
• Abdominal pain
• Headache

Are there any serious side effects to watch for? While rare, serious side effects can occur and may include:

• Severe allergic reactions (anaphylaxis)
• Clostridium difficile-associated diarrhea
• Liver problems
• Blood disorders

Drug Interactions: What to Know Before Taking Amoxicillin

Amoxicillin can interact with various medications, supplements, and even certain medical conditions. These interactions can affect the efficacy of amoxicillin or increase the risk of side effects.

Which drugs are known to interact with amoxicillin? Some notable interactions include:

• Oral contraceptives (may decrease effectiveness)
• Warfarin (may increase bleeding risk)
• Probenecid (may increase amoxicillin levels)
• Methotrexate (may increase toxicity)

Can amoxicillin be taken with over-the-counter medications? While many OTC medications are safe to take with amoxicillin, it’s always best to consult with a healthcare provider or pharmacist before combining medications.

Precautions and Contraindications for Amoxicillin Use

Certain individuals may need to avoid amoxicillin or use it with caution due to pre-existing conditions or other factors. It’s essential to inform healthcare providers of all medical conditions and medications before starting amoxicillin treatment.

Who should exercise caution when taking amoxicillin? Special considerations are needed for:

• Individuals with a history of penicillin allergy
• Patients with kidney disease
• Those with a history of asthma or allergies
• Pregnant or breastfeeding women
• Individuals with mononucleosis

Amoxicillin in Special Populations: Pregnancy, Breastfeeding, and Pediatrics

The use of amoxicillin in certain populations requires careful consideration and monitoring. While generally considered safe, the benefits and risks must be weighed carefully in these groups.

Is amoxicillin safe during pregnancy? Amoxicillin is generally considered safe during pregnancy and is classified as Category B by the FDA. However, it should only be used when clearly needed and under medical supervision.

Can amoxicillin be used while breastfeeding? Amoxicillin is considered compatible with breastfeeding. Small amounts may pass into breast milk, but adverse effects on breastfed infants are rare.

How is amoxicillin used in pediatric patients? Amoxicillin is commonly prescribed for children, with dosages adjusted based on weight and age. It’s available in child-friendly formulations such as chewable tablets and oral suspension.

Monitoring and Follow-up During Amoxicillin Treatment

While taking amoxicillin, it’s important to monitor for both effectiveness and potential side effects. Regular communication with healthcare providers can help ensure the best possible outcomes.

What should patients watch for during treatment? Patients should be alert for:

• Improvement of symptoms
• Any new or worsening side effects
• Signs of allergic reactions
• Persistent symptoms after completing the full course

When should patients follow up with their healthcare provider? Follow-up is typically recommended if:

• Symptoms don’t improve within a few days
• Side effects become severe or persistent
• New symptoms develop during treatment

Alternatives to Amoxicillin: When to Consider Other Options

While amoxicillin is a first-line treatment for many bacterial infections, there are situations where alternative antibiotics may be more appropriate. Understanding these scenarios can help patients and healthcare providers make informed decisions about treatment.

When might alternatives to amoxicillin be considered? Alternative antibiotics may be prescribed in cases of:

• Penicillin allergy
• Bacterial resistance to amoxicillin
• Infections caused by organisms not susceptible to amoxicillin
• Treatment failure with amoxicillin

What are some common alternatives to amoxicillin? Depending on the specific infection and patient factors, alternatives may include:

• Cephalosporins (e.g., cefdinir, cefuroxime)
• Macrolides (e.g., azithromycin, clarithromycin)
• Fluoroquinolones (e.g., ciprofloxacin, levofloxacin)
• Tetracyclines (e.g., doxycycline)

The Role of Amoxicillin in Antibiotic Resistance

Antibiotic resistance is a growing global concern, and the appropriate use of antibiotics like amoxicillin plays a crucial role in combating this issue. Understanding the relationship between amoxicillin use and antibiotic resistance can help promote responsible antibiotic stewardship.

How does amoxicillin contribute to antibiotic resistance? Overuse or misuse of amoxicillin can lead to:

• Selection of resistant bacterial strains
• Increased prevalence of resistant infections
• Reduced efficacy of amoxicillin for future treatments

What steps can be taken to minimize antibiotic resistance? To help combat antibiotic resistance:

• Only use amoxicillin when prescribed by a healthcare provider
• Complete the full course of treatment as prescribed
• Avoid sharing antibiotics with others
• Properly dispose of unused antibiotics

Amoxicillin Storage and Handling: Ensuring Medication Efficacy

Proper storage and handling of amoxicillin are essential to maintain its effectiveness and safety. Following guidelines for storage can help ensure that the medication remains potent throughout its intended use period.

How should amoxicillin be stored? Key storage considerations include:

• Keep at room temperature, away from excessive heat and moisture
• Store in the original container or as directed by the pharmacist
• Keep out of reach of children
• For liquid formulations, refrigerate if instructed and shake well before each use

What is the shelf life of amoxicillin? The expiration date on the packaging should be observed. Typically, amoxicillin tablets and capsules remain stable for several years when stored properly. Liquid formulations generally have a shorter shelf life, especially once reconstituted.

Amoxicillin in Combination Therapy: Enhancing Treatment Efficacy

In some cases, amoxicillin is prescribed in combination with other medications to enhance its effectiveness or broaden its spectrum of activity. These combination therapies can be particularly useful for certain types of infections or in situations where resistance to amoxicillin alone is a concern.

What are common combinations involving amoxicillin? Some frequently used combinations include:

• Amoxicillin-clavulanic acid (Augmentin): Combines amoxicillin with a beta-lactamase inhibitor to overcome certain types of bacterial resistance
• Amoxicillin with clarithromycin and a proton pump inhibitor: Used for Helicobacter pylori eradication in peptic ulcer disease
• Amoxicillin with metronidazole: Sometimes used for mixed aerobic and anaerobic infections

Are combination therapies always more effective? While combination therapies can be beneficial in specific scenarios, they are not always necessary or superior to amoxicillin alone. The decision to use combination therapy should be based on the specific infection, local resistance patterns, and individual patient factors.

Economic Considerations: Cost-Effectiveness of Amoxicillin

Amoxicillin is generally considered a cost-effective antibiotic option due to its broad availability as a generic medication. Understanding the economic aspects of amoxicillin use can be helpful for both healthcare systems and individual patients.

Why is amoxicillin often a cost-effective choice? Factors contributing to its cost-effectiveness include:

• Wide availability as a generic medication
• Generally lower cost compared to newer antibiotics
• Broad spectrum of activity, reducing the need for multiple medications in many cases
• Well-established safety profile, potentially reducing costs associated with adverse effects

Are there situations where more expensive alternatives might be preferred? In some cases, newer or more expensive antibiotics may be necessary, such as:

• Infections caused by resistant organisms
• Severe infections requiring broader spectrum coverage
• Patients with allergies or contraindications to amoxicillin

Future Directions: Amoxicillin Research and Development

While amoxicillin has been a staple in antibiotic therapy for decades, ongoing research continues to explore new applications, formulations, and strategies to enhance its effectiveness and combat resistance.

What areas of amoxicillin research are currently being explored? Some areas of interest include:

• Development of new combination therapies to address resistance
• Investigation of novel delivery methods to improve bioavailability and reduce side effects
• Exploration of amoxicillin’s potential in treating emerging infectious diseases
• Studies on optimizing dosing regimens to maximize efficacy while minimizing resistance development

How might future developments impact amoxicillin use? Potential outcomes of ongoing research could include:

• Extended-release formulations for less frequent dosing
• New combination products targeting specific resistant pathogens
• Improved methods for rapid susceptibility testing to guide appropriate use
• Enhanced understanding of amoxicillin’s role in the microbiome and long-term health effects

In conclusion, amoxicillin remains a cornerstone of antibiotic therapy, valued for its efficacy, safety profile, and cost-effectiveness. As research continues and our understanding of bacterial infections evolves, the role of amoxicillin in medical practice is likely to adapt and potentially expand. Healthcare providers and patients alike should stay informed about current best practices for amoxicillin use to ensure optimal outcomes and responsible antibiotic stewardship.

Amoxicillin Interactions Checker – Drugs.com

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There are 37 drugs known to interact with
amoxicillin, along with
6 disease interactions.

Of the total drug interactions,
4 are major, 25 are moderate, and 8 are minor.

Does amoxicillin interact with my other drugs?

Enter other medications to view a detailed report.

• View all 37 medications that may interact with amoxicillin
• View amoxicillin disease interactions (6)

Most frequently checked interactions

View interaction reports for amoxicillin and the medicines listed below.

• Major
• Moderate
• Minor
• Unknown

• Ambien (zolpidem)
• Aspirin Low Strength (aspirin)
• Augmentin (amoxicillin / clavulanate)
• Benadryl (diphenhydramine)
• Claritin (loratadine)
• CoQ10 (ubiquinone)
• Cymbalta (duloxetine)
• Eliquis (apixaban)
• Fish Oil (omega-3 polyunsaturated fatty acids)
• Flexeril (cyclobenzaprine)
• Flonase (fluticasone nasal)
• Lexapro (escitalopram)
• Lipitor (atorvastatin)
• Lyrica (pregabalin)
• Metoprolol Succinate ER (metoprolol)
• MiraLAX (polyethylene glycol 3350)
• Mucinex (guaifenesin)
• Nexium (esomeprazole)
• Norco (acetaminophen / hydrocodone)
• Paracetamol (acetaminophen)
• Singulair (montelukast)
• Synthroid (levothyroxine)
• Tylenol (acetaminophen)
• Vitamin B12 (cyanocobalamin)
• Vitamin C (ascorbic acid)
• Vitamin D3 (cholecalciferol)
• Xanax (alprazolam)
• Zofran (ondansetron)
• Zoloft (sertraline)
• Zyrtec (cetirizine)

Amoxicillin disease interactions

There are 6 disease interactions with amoxicillin which include:

• colitis
• mononucleosis
• diabetes
• PKU
• renal dysfunction
• hemodialysis

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Related treatment guides

• Bacterial Infection
• Bacterial Endocarditis Prevention
• Actinomycosis
• Anthrax Prophylaxis

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.

Major	Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate	Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor	Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown	No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Side effects, dosage, uses, and more

1. Amoxicillin is an antibiotic. It’s used to treat infections caused by certain types of bacteria.
2. Amoxicillin oral tablet comes as immediate-release (IR) or chewable tablets. The chewable tablet and IR tablet are only available as generic drugs.
3. Amoxicillin also comes as a capsule and a suspension. All forms are taken by mouth. (This article focuses on the oral tablet forms only.)

Amoxicillin oral tablet does not cause drowsiness, but it can cause other side effects.

More common side effects

The more common side effects of amoxicillin oral tablet can include:

• nausea
• vomiting
• diarrhea
• rash
• vaginal yeast infection

If these side effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk with your doctor or pharmacist.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

• Hypersensitivity reactions. Symptoms can include:
  • flu-like symptoms, such as fever, body aches, or sore throat
  • a painful red or purple rash that spreads
  • blisters that could cause the skin to break down and cause open sores
• Liver damage. This effect is rare. Symptoms can include:
  • increased liver enzymes shown on a blood test
  • pain in the abdomen (stomach area)
  • yellowing of the skin and eyes
  • tiredness
• Serious skin reaction.* This side effect is rare. Symptoms may include:
  • flu-like symptoms, such as fever, body aches, or sore throat
  • a skin rash and discoloration
  • swollen lymph nodes
  • itchiness

* Serious skin reactions were not reported in clinical trials of amoxicillin. However, they have been reported since the drug was approved.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare professional who knows your medical history.

• Finishing therapy: It’s important to finish the entire course of amoxicillin treatment as prescribed by your doctor. Do not stop taking this drug or skip doses if you start to feel better. This could cause your infection to last longer. You could also develop a resistance to the medication. This means that if you get a bacterial infection in the future, you may not be able to treat it with amoxicillin.
• Diarrhea: Amoxicillin may cause diarrhea. Call your doctor if you have bloody or watery diarrhea, with or without stomach cramps and fever.
• Serious skin reaction: Skin reactions can occur during amoxicillin treatment. In rare cases, serious skin reactions such as Steven-Johnson syndrome or toxic epidermal necrolysis may occur. Talk with your doctor if you experience a skin rash or condition that becomes bothersome or doesn’t go away.
• Serious allergic reaction: This drug can cause a serious allergic reaction. This reaction can be fatal (cause death). If you’re allergic to other antibiotics, such as penicillins or cephalosporins, your risk for an allergic reaction may be higher. Call your doctor right away if you have trouble breathing or swelling of your throat or tongue while you’re taking this drug.

Amoxicillin is a prescription antibiotic. It’s used to treat infections caused by a certain type of bacteria. It may be used as part of combination therapy. This means you may need to take it with other medications.

The oral tablet comes as an immediate-release (IR) tablet and chewable tablet. These are only available as generic drugs.

Generic drugs usually cost less. Amoxicillin also comes as a capsule and a suspension. All forms are taken by mouth. This article focuses on the oral tablet forms only.

Why it’s used

Amoxicillin is an antibiotic. It’s used to treat infections caused by a certain type of bacteria.

Amoxicillin may be used as part of combination therapy. This means you may need to take it with other medications.

How it works

Amoxicillin belongs to a class of drugs called penicillins. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Amoxicillin works by killing bacteria and stopping its growth in your body.

How long it lasts

The effects of amoxicillin should last as long as you continue taking the drug. Amoxicillin is typically a short-term treatment.

Amoxicillin typically stays in your system for 8 to 12 hours after your most recent dose. It’s possible to continue experiencing some effects of amoxicillin after you stop taking the drug, especially during this 8-hour to 12-hour period. However, the drug’s effects typically end when your treatment ends or soon afterward.

There have been reports of diarrhea lasting for up to 2 months after people stopped amoxicillin treatment. If you experience diarrhea after stopping amoxicillin, especially along with a fever or abdominal pain, talk with your doctor.

Amoxicillin oral tablets start working right away after taking a dose. It can take up to a couple of days after your first dose for the drug to start reducing symptoms of your infection.

If you have questions about how long amoxicillin treatment or its effects last, you can talk with your doctor.

As with all medications, the cost of amoxicillin can vary. The actual price you’ll pay depends on your insurance plan, your location, and the pharmacy you use. You can refer to this article for details about the cost of amoxicillin treatment.

Financial and insurance assistance

Financial assistance to help you pay for amoxicillin may be available.

Medicine Assistance Tool and NeedyMeds are two websites offering resources that may help decrease the price you pay for amoxicillin. They also offer tools to help you find low cost healthcare, as well as educational resources. To learn more, visit their sites.

You can also refer to the coupons in this article for possible ways to save on amoxicillin oral tablets.

To learn more about saving money on prescriptions, check out this article.

Mail-order pharmacies

Amoxicillin may be available through a mail-order pharmacy. Using this service may help lower the drug’s cost and allow you to get your medication without leaving home.

If you’re interested in this option, check with your doctor, pharmacist, or insurance company. Some Medicare plans may help cover the cost of mail-order medications.

If you don’t have insurance, you can ask your doctor or pharmacist about online pharmacy options.

This dosage information is for amoxicillin oral tablet. All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

• your age
• the condition being treated
• how severe your condition is
• other medical conditions you have
• how you react to the first dose

Forms and strengths

Generic: amoxicillin

• Form: oral tablet
• Strengths: 500 milligrams (mg), 875 mg
• Form: oral chewable tablet
• Strengths: 125 mg, 250 mg

Note: Amoxicillin also comes as a capsule and a suspension, both of which are taken by mouth. This article focuses on the oral tablet forms only.

Dosage for infections of the ears, nose, and throat

IMMEDIATE-RELEASE TABLET AND CHEWABLE TABLET

Adult dosage (ages 18–64 years)

Typical dosage is 500 mg every 12 hours, or 250 mg every 8 hours.

Child dosage (ages 3 months–17 years)

Typical dosage is 25 mg per kilogram per day (mg/kg/day) in divided doses every 12 hours, or 20 mg/kg/day in divided doses every 8 hours.

The children’s dosage listed here is meant for children who weigh less than 88 pounds (40 kg). Children who weigh more than 88 pounds should be dosed according to the adult recommendations.

Child dosage (ages 0–2 months)

Maximum dosage is 30 mg/kg/day. Your child’s doctor can tell you more about dosage.

Dosage for urinary tract infections

Adult dosage (ages 18–64 years)

Typical dosage is 500 mg every 12 hours, or 250 mg every 8 hours.

Child dosage (ages 3 months–17 years)

Typical dosage is 25 mg/kg/day in divided doses every 12 hours, or 20 mg/kg/day in divided doses every 8 hours.

Child dosage (ages 0–2 months)

Maximum dosage is 30 mg/kg/day. Your child’s doctor can tell you more about dosage.

Older adult dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects.

Your doctor may start you on a lower dose or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.

Special considerations

• For children’s dosage: The children’s dosage listed here is meant for children who weigh less than 88 pounds (40 kg). Children who weigh more than 88 pounds should be dosed according to the adult recommendations.

Dosage for skin infections

Adult dosage (ages 18–64 years)

Typical dosage is 500 mg every 12 hours, or 250 mg every 8 hours.

Child dosage (ages 3 months–17 years)

Typical dosage is 25 mg/kg/day in divided doses every 12 hours, or 20 mg/kg/day in divided doses every 8 hours.

The dosage listed here is meant for children who weigh less than 88 pounds (40 kg). Children who weigh more than 88 pounds should be dosed according to the adult recommendations.

Child dosage (ages 0–2 months)

Maximum dosage is 30 mg/kg/day. Your child’s doctor can tell you more about dosage.

Older adult dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects.

Your doctor may start you on a lower dose or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.

Dosage for lower respiratory tract infections

Adult dosage (ages 18–64 years)

Typical dosage is 875 mg every 12 hours, or 500 mg every 8 hours.

Child dosage (ages 3 months–17 years)

Typical dosage is 45 mg/kg/day in divided doses every 12 hours, or 40 mg/kg/day in divided doses every 8 hours.

Child dosage (ages 0–2 months)

Maximum dosage is 30 mg/kg/day. This is meant for children who weigh less than 88 pounds (40 kg). Children who weigh more than 88 pounds should be dosed according to the adult recommendations. Your child’s doctor can tell you more about dosage.

Older adult dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects.

Your doctor may start you on a lower dose or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.

Dosage for gonorrhea

Adult dosage (ages 18–64 years)

Typical dosage is 3 grams (g) as a single dose.

Child dosage (ages 24 months–17 years)

Typical dosage is 50 mg/kg amoxicillin combined with 25 mg/kg probenecid as a single dose. The children’s dosage listed here is meant for children who weigh less than 88 pounds (40 kg).

Children who weigh more than 88 pounds should be dosed according to the adult recommendations.

Child dosage (ages 0–23 months)

This medication should not be used in children younger than 2 years of age for treatment of gonorrhea.

Older adult dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects.

Your doctor may start you on a lower dose or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.

Dosage for stomach and intestinal ulcers

Adult dosage (ages 18–64 years)

• Typical dosage for triple therapy: 1 g amoxicillin with 500 mg clarithromycin and 30 mg of lansoprazole, all given twice per day for 14 days.
• Typical dosage for dual therapy: 1 g amoxicillin and 30 mg of lansoprazole, given three times per day for 14 days.

Child dosage (ages 0–17 years)

This drug has not been studied in children to treat stomach and intestinal ulcers.

Older adult dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects.

Your doctor may start you on a lower dose or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.

Amoxicillin oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking.

To find out how this drug might interact with something else you’re taking, talk with your doctor or pharmacist.

Examples of drugs that can cause interactions with amoxicillin are listed below.

Drugs that increase the risk of side effects from amoxicillin

Taking amoxicillin with certain medications raises your risk of side effects from amoxicillin. This is because the amount of amoxicillin in your body may be increased. Examples of these drugs include:

• Probenecid: Taking probenecid with amoxicillin could lead to increased blood levels of amoxicillin. A doctor may need to decrease the dose of amoxicillin in some patients.
• Allopurinol: If you use allopurinol and amoxicillin together, you may develop a rash.

Interactions that increase the risk of side effects from other drugs

Taking amoxicillin with certain medications raises your risk of side effects from these medications. Amoxicillin increases the amount of these drugs in your body.

Examples of these drugs include drugs to treat blood clots. These are called anticoagulants (or blood thinners) and include warfarin (Jantoven), apixaban (Eliquis), heparin, and others.

If you use these drugs with amoxicillin, you have a higher risk of bleeding. Your doctor may adjust your dose of amoxicillin as a result.

Interactions that can make your drugs less effective

When amoxicillin is less effective: When amoxicillin is used with certain drugs, it may not work as well. In vitro studies have shown potential interactions that can cause the amount of amoxicillin in your body may be decreased.

Because in vitro studies are only conducted in a lab and not on live subjects, it is not clear whether this can significantly impact you if you’re taking amoxicillin with these drugs.

Nevertheless, examples of these drugs include:

• Chloramphenicol
  • If you use these drugs together, your doctor will likely keep your dosage of amoxicillin the same.
• Macrolides, such as erythromycin, clarithromycin, or azithromycin
  • If you use these drugs together, your doctor will likely keep your dosage of amoxicillin the same.
• Sulfonamides, such as sulfamethoxazole
  • If you use these drugs together, your doctor will likely keep your dosage of amoxicillin the same.
• Tetracyclines, such as tetracycline or doxycycline
  • If you use these drugs together, your doctor will likely keep your dosage of amoxicillin the same.

When other drugs are less effective: When certain drugs are used with amoxicillin, they may not work as well. This is because the amount of these drugs in your body may be decreased. Examples of these drugs include:

• Oral contraceptives (birth control)
  • If you need to take amoxicillin, you should consider using a barrier method of birth control while on amoxicillin. Or, your doctor may prescribe a different form of birth control for you.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare professional about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you’re taking.

This drug comes with several warnings.

Allergies

Amoxicillin can cause a severe allergic reaction. Symptoms can include:

• trouble breathing
• swelling of your throat or tongue

If you have an allergic reaction, call your doctor or seek guidance from America’s Poison Centers at 800-222-1222 or through its online tool. If your symptoms are severe, call 911 or go to the nearest emergency room. Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

Warnings for people with certain health conditions

For people with mononucleosis (mono or kissing disease): Amoxicillin raises your risk of developing a severe rash.

For people with diabetes: Amoxicillin may cause you to have a false-positive reaction when testing for glucose (sugar) in the urine. Talk with your doctor about how to manage your blood sugar while taking amoxicillin.

For people with kidney disease: If you have severe kidney disease, your kidneys may not clear this drug from your body quickly. As a result, levels of amoxicillin may build up in your body. To help prevent this, your doctor may give you a lower dose of this drug.

Warnings for other groups

For pregnant people: Research in animals has not shown adverse effects on the fetus when pregnant animals were exposed to amoxicillin. There haven’t been enough studies done on humans to be certain if the drug poses a risk to the fetus. However, you may want to still speak with your doctor if you’re pregnant or planning to become pregnant.

For people who are breastfeeding (nursing): Amoxicillin may pass into breast milk and may cause side effects in a child who is breastfed. Talk with your doctor if you are breastfeeding your child. You may need to decide whether to stop breastfeeding or stop taking this medication.

For older adults (ages 65 years and over): The kidneys of older adults may not work as well as those of younger adults. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects.

Amoxicillin oral tablet is used for short-term treatment. It comes with serious risks if you don’t take it as prescribed.

If you stop taking the drug suddenly or don’t take it at all: Your bacterial infection may not heal or may get worse.

If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

It’s important to finish the entire course of treatment as prescribed by your doctor. Do not stop taking the drug or skip doses if you start to feel better. This could cause your infection to last longer.

You could also develop a resistance to the medication. This means if you get a bacterial infection in the future, you may not be able to treat it with amoxicillin.

If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose may not be significant at less than 250 mg/kg. In higher-dose cases, it may lead to kidney failure.

If you think you’ve taken too much of this drug, call your doctor or seek guidance from America’s Poison Centers at 800-222-1222 or through its online tool. If your symptoms are severe, call 911 or go to the nearest emergency room right away.

What to do if you miss a dose: Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.

How to tell if the drug is working: The symptoms of your infection should ease.

Keep these considerations in mind if your doctor prescribes amoxicillin oral tablet for you.

General

• Take this drug at the time(s) recommended by your doctor.
• You can take the amoxicillin capsule, tablet, or suspension with or without food.
• You can crush, cut, or chew regular or chewable amoxicillin tablets.

Storage

Store amoxicillin at room temperature between 59°F and 86°F (15°C and 30°C). Keep this drug away from light. Don’t store this medication in moist or damp areas, such as bathrooms.

Refills

A prescription for this medication may be refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

When traveling with your medication:

• Always carry your medication with you. When flying, never put it in a checked bag. Keep it in your carry-on bag.
• Don’t worry about airport X-ray machines. They can’t hurt your medication.
• You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled box with you.
• Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Clinical monitoring

You and your doctor should monitor certain health issues. This can help make sure you stay safe while you take this drug. These issues include your:

• Kidney function. Blood tests can check how well your kidneys are working. If your kidneys aren’t working well, your doctor may decide to lower your dosage of this drug.
• Liver function. Blood tests can check how well your liver is working. If your liver isn’t working well, your doctor may lower your dosage of this drug.

The cost of these blood tests will depend on your insurance coverage.

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk with your doctor about other drug options that may work for you.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication.