Best medication for knee pain: Types and side effects

Several medication options are available to treat knee pain, including over-the-counter drugs, prescription options, and injections.

Knee pain can start slowly and gradually worsen over time. The medication a person takes to treat knee pain will depend on the cause and severity of the pain.

There are many potential causes of knee pain, including:

• overuse
• arthritis
• Baker’s cyst
• infection in the joint
• bursitis
• torn cartilage
• strain or sprain

This article looks at the best medication for knee pain, home remedies, prevention of knee pain, and when to contact a doctor.

People may treat mild to moderate knee pain with over-the-counter (OTC) medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs) or acetaminophen.

NSAIDs relieve inflammation and help with pain management. Some types of NSAIDs are available OTC to treat mild to moderate pain.

OTC NSAIDs includeibuprofen, available under brand names such as Motrin and Advil, and naproxen sodium, available under the brand name Aleve.

Dosage

An adult can take ibuprofen at 800–1,200 milligrams (mg) per day. For naproxen sodium, the daily dose should not be more than 1,375 mg.

A person should follow the instructions on the medication guide and never exceed the recommended daily dose.

Precautions

NSAIDs may increase the risk of stroke or heart attack, which may occur suddenly. These risks may be even higher in people who:

• smoke
• have previously had a heart attack or stroke
• have diabetes or high cholesterol

Doctors also associate NSAIDs with a risk of ulcers and holes and bleeding in the intestine and stomach. These risks may be higher for people who drink alcohol frequently, are older adults, or have other health conditions.

The risks associated with NSAIDs may increase for people who take the medication for a long time.

NSAIDs may also interact with certain medications, including:

• other NSAIDs
• anticoagulants, such as warfarin
• oral steroids, such as prednisone
• selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine and citalopram
• serotonin-norepinephrine reuptake inhibitors (SNRIs), such as duloxetine

Read on for the differences between SSRIs and SNRIs.

Potential side effects

NSAIDs such as naproxen may cause side effects, which can include:

• diarrhea
• bloating and gas
• constipation
• ringing in the ears
• dizziness
• drowsiness
• nervousness

People should speak with a medical professional to discuss the potential side effects of NSAIDs.

Acetaminophen is an analgesic or pain reliever that also reduces fever. Some people take acetaminophen to reduce pain caused by osteoarthritis, a type of arthritis that affects the joints, including the knee. People also take acetaminophen to relieve other mild to moderate pain.

Examples of medications that contain acetaminophen include:

• Panadol
• Tylenol
• Actamin
• FeverAll

Dosage

The maximum amount of acetaminophen a person should take in one dose is 1,000 mg. A person should not take more than 4,000 mg per day.

Precautions

If a person takes too much acetaminophen, there is a risk of liver damage. This may be severe, require a liver transplant, or be fatal.

Potential side effects

Possible side effects include:

• rash
• itching
• hives
• swelling in the:
  • tongue
  • face
  • throat
  • ankles
  • feet
  • legs
• blistering or peeling skin
• difficulty swallowing or breathing
• hoarseness

People should speak with a doctor if they experience these symptoms after taking acetaminophen.

A person may require stronger medication for more severe pain, which a doctor can prescribe. These may include higher dosage NSAIDs and COX-2 inhibitors, also called coxibs.

Examples of prescribed NSAIDs include:

• high dose ibuprofen
• high dose naproxen
• diclofenac (Voltaren)

Examples of coxibs include celecoxib (Celebrex) and etoricoxib. A person can take these medications as tablets orally or apply them to the knee as a gel or cream.

Dosage

According to the National Library of Medicine, the maximum daily dose of each medication is:

• ibuprofen: 2,400 mg
• naproxen: 1,000 mg
• naproxen sodium: 1,375 mg
• diclofenac: 150 mg
• celecoxib: 400 mg
• etoricoxib: 60 mg

Precautions

People who take NSAIDs or coxibs are at risk of gastrointestinal problems. There is a greater risk of complications if a person:

• drinks alcohol frequently
• takes corticosteroids
• takes SSRIs
• takes blood thinning medication
• takes several anti-inflammatory pain relief medications together
• has had stomach bleeding or gastritis
• has gastrointestinal conditions, such as Crohn’s disease or ulcerative colitis
• has a bacterial infection with Helicobacter pylori, which can cause ulcers
• is 65 years or older

Potential side effects

Side effects of prescription NSAIDs and coxibs may include:

• indigestion and stomach pain
• gas and bloating
• ulcers
• constipation
• gastritis
• sore throat
• dizziness
• cold symptoms

If a person experiences any of these symptoms and is at high risk, they should consult a medical professional.

If a person has severe pain from injury or illness, such as arthritis, a doctor may administer an injection to treat the pain. Doctors may recommend hydrocortisone or hyaluronic acid injections.

Hydrocortisone injection

This type of injection is a corticosteroid. A doctor may administer a hydrocortisone injection directly into the knee joint.

This medication can treat knee pain from various causes, including injury, arthritis, and bursitis. The injection helps reduce swelling and pain and makes movement easier.

Dosage

A person may be able to have injections in the knee up to four times a year. The dosage can vary between 5 mg and 50 mg of hydrocortisone.

Precautions

Hydrocortisone may not be suitable for people who:

• have an infection
• have or have had depression
• have been in recent contact with a person who has:
  • measles
  • shingles
  • chickenpox
• have recently had vaccinations or are having vaccinations soon
• are pregnant, breastfeeding, or trying to become pregnant

Hydrocortisone may also cause complications in people who have:

• high blood pressure
• diabetes
• osteoporosis
• glaucoma
• unhealed wounds

People should speak with a doctor about the injections’ potential risk factors and complications.

Potential side effects

Side effects of hydrocortisone injections may include pain and swelling at the injection site and bruising.

Serious side effects include:

• signs of infection such as:
  • fever
  • chills
  • sore throat
  • ear or sinus pain
• depression or mood swings
• puffy face or weight gain in the upper belly or back
• swelling and throbbing in the legs or arms
• chest pain
• confusion and sleepiness
• changes to vision

A person can speak with a medical professional if experiencing any of the side effects described above.

Hyaluronic acid

A doctor may inject hyaluronic acid into the knee to increase the supply of the acid. This can help relieve pain and may improve other symptoms of conditions that affect the knee joint, such as osteoarthritis.

Dosage

Depending on which hyaluronic acid a doctor uses, they may administer one to five injections over several weeks.

Precautions

If a person is pregnant or breastfeeding, they should let a doctor know before starting this medication. People should also inform a doctor if they develop an infection in the knee or a skin problem.

Potential side effects

Side effects of hyaluronic acid injection may include pain and swelling at the injection site and difficulty moving the knee immediately after the injection. These symptoms are usually temporary, and applying ice helps ease the pain.

Less common side effects include:

• bleeding
• blistering
• burning or coldness
• discoloration of skin
• hives or rash
• joint infection
• inflammation
• itching or stinging
• lumps
• numbness and tingling
• redness, soreness, and tenderness
• ulceration and warmth at the injection site

People should seek medical attention if they experience mild or more severe reactions.

Knee pain may sometimes go away on its own. If the pain is not severe, a person may be able to treat it at home by:

• putting as little weight as possible on the knee
• avoiding standing for a long time
• using an ice pack on the knee for up to 20 minutes every 2–3 hours
• taking acetaminophen

Learn more about the home remedies for knee pain.

To help prevent knee pain, a person can:

• balance rest and exercise
• maintain a moderate body weight
• wear suitable footwear with arch supports

A person should contact a doctor about knee pain if:

• the pain is severe
• there is swelling in the knee
• there is no improvement after a week
• there is no movement
• the knee cannot bear weight
• the knee locks or buckles

The medication a person receives for knee pain can depend on the cause and severity of the pain.

A person may take OTC medication for mild to moderate pain, such as ibuprofen or naproxen. If the pain is more severe, a person may require medication prescribed by a doctor, such as a higher dose of NSAID or COX-2 inhibitors. A doctor may sometimes administer injections and inject hydrocortisone or hyaluronic acid into the affected area.

A person can also treat knee pain at home by resting, raising the knee, and applying ice.

Best medication for knee pain: Types and side effects

Several medication options are available to treat knee pain, including over-the-counter drugs, prescription options, and injections.

Knee pain can start slowly and gradually worsen over time. The medication a person takes to treat knee pain will depend on the cause and severity of the pain.

There are many potential causes of knee pain, including:

• overuse
• arthritis
• Baker’s cyst
• infection in the joint
• bursitis
• torn cartilage
• strain or sprain

This article looks at the best medication for knee pain, home remedies, prevention of knee pain, and when to contact a doctor.

People may treat mild to moderate knee pain with over-the-counter (OTC) medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs) or acetaminophen.

NSAIDs relieve inflammation and help with pain management. Some types of NSAIDs are available OTC to treat mild to moderate pain.

OTC NSAIDs includeibuprofen, available under brand names such as Motrin and Advil, and naproxen sodium, available under the brand name Aleve.

Dosage

An adult can take ibuprofen at 800–1,200 milligrams (mg) per day. For naproxen sodium, the daily dose should not be more than 1,375 mg.

A person should follow the instructions on the medication guide and never exceed the recommended daily dose.

Precautions

NSAIDs may increase the risk of stroke or heart attack, which may occur suddenly. These risks may be even higher in people who:

• smoke
• have previously had a heart attack or stroke
• have diabetes or high cholesterol

Doctors also associate NSAIDs with a risk of ulcers and holes and bleeding in the intestine and stomach. These risks may be higher for people who drink alcohol frequently, are older adults, or have other health conditions.

The risks associated with NSAIDs may increase for people who take the medication for a long time.

NSAIDs may also interact with certain medications, including:

• other NSAIDs
• anticoagulants, such as warfarin
• oral steroids, such as prednisone
• selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine and citalopram
• serotonin-norepinephrine reuptake inhibitors (SNRIs), such as duloxetine

Read on for the differences between SSRIs and SNRIs.

Potential side effects

NSAIDs such as naproxen may cause side effects, which can include:

• diarrhea
• bloating and gas
• constipation
• ringing in the ears
• dizziness
• drowsiness
• nervousness

People should speak with a medical professional to discuss the potential side effects of NSAIDs.

Acetaminophen is an analgesic or pain reliever that also reduces fever. Some people take acetaminophen to reduce pain caused by osteoarthritis, a type of arthritis that affects the joints, including the knee. People also take acetaminophen to relieve other mild to moderate pain.

Examples of medications that contain acetaminophen include:

• Panadol
• Tylenol
• Actamin
• FeverAll

Dosage

The maximum amount of acetaminophen a person should take in one dose is 1,000 mg. A person should not take more than 4,000 mg per day.

Precautions

If a person takes too much acetaminophen, there is a risk of liver damage. This may be severe, require a liver transplant, or be fatal.

Potential side effects

Possible side effects include:

• rash
• itching
• hives
• swelling in the:
  • tongue
  • face
  • throat
  • ankles
  • feet
  • legs
• blistering or peeling skin
• difficulty swallowing or breathing
• hoarseness

People should speak with a doctor if they experience these symptoms after taking acetaminophen.

A person may require stronger medication for more severe pain, which a doctor can prescribe. These may include higher dosage NSAIDs and COX-2 inhibitors, also called coxibs.

Examples of prescribed NSAIDs include:

• high dose ibuprofen
• high dose naproxen
• diclofenac (Voltaren)

Examples of coxibs include celecoxib (Celebrex) and etoricoxib. A person can take these medications as tablets orally or apply them to the knee as a gel or cream.

Dosage

According to the National Library of Medicine, the maximum daily dose of each medication is:

• ibuprofen: 2,400 mg
• naproxen: 1,000 mg
• naproxen sodium: 1,375 mg
• diclofenac: 150 mg
• celecoxib: 400 mg
• etoricoxib: 60 mg

Precautions

People who take NSAIDs or coxibs are at risk of gastrointestinal problems. There is a greater risk of complications if a person:

• drinks alcohol frequently
• takes corticosteroids
• takes SSRIs
• takes blood thinning medication
• takes several anti-inflammatory pain relief medications together
• has had stomach bleeding or gastritis
• has gastrointestinal conditions, such as Crohn’s disease or ulcerative colitis
• has a bacterial infection with Helicobacter pylori, which can cause ulcers
• is 65 years or older

Potential side effects

Side effects of prescription NSAIDs and coxibs may include:

• indigestion and stomach pain
• gas and bloating
• ulcers
• constipation
• gastritis
• sore throat
• dizziness
• cold symptoms

If a person experiences any of these symptoms and is at high risk, they should consult a medical professional.

If a person has severe pain from injury or illness, such as arthritis, a doctor may administer an injection to treat the pain. Doctors may recommend hydrocortisone or hyaluronic acid injections.

Hydrocortisone injection

This type of injection is a corticosteroid. A doctor may administer a hydrocortisone injection directly into the knee joint.

This medication can treat knee pain from various causes, including injury, arthritis, and bursitis. The injection helps reduce swelling and pain and makes movement easier.

Dosage

A person may be able to have injections in the knee up to four times a year. The dosage can vary between 5 mg and 50 mg of hydrocortisone.

Precautions

Hydrocortisone may not be suitable for people who:

• have an infection
• have or have had depression
• have been in recent contact with a person who has:
  • measles
  • shingles
  • chickenpox
• have recently had vaccinations or are having vaccinations soon
• are pregnant, breastfeeding, or trying to become pregnant

Hydrocortisone may also cause complications in people who have:

• high blood pressure
• diabetes
• osteoporosis
• glaucoma
• unhealed wounds

People should speak with a doctor about the injections’ potential risk factors and complications.

Potential side effects

Side effects of hydrocortisone injections may include pain and swelling at the injection site and bruising.

Serious side effects include:

• signs of infection such as:
  • fever
  • chills
  • sore throat
  • ear or sinus pain
• depression or mood swings
• puffy face or weight gain in the upper belly or back
• swelling and throbbing in the legs or arms
• chest pain
• confusion and sleepiness
• changes to vision

A person can speak with a medical professional if experiencing any of the side effects described above.

Hyaluronic acid

A doctor may inject hyaluronic acid into the knee to increase the supply of the acid. This can help relieve pain and may improve other symptoms of conditions that affect the knee joint, such as osteoarthritis.

Dosage

Depending on which hyaluronic acid a doctor uses, they may administer one to five injections over several weeks.

Precautions

If a person is pregnant or breastfeeding, they should let a doctor know before starting this medication. People should also inform a doctor if they develop an infection in the knee or a skin problem.

Potential side effects

Side effects of hyaluronic acid injection may include pain and swelling at the injection site and difficulty moving the knee immediately after the injection. These symptoms are usually temporary, and applying ice helps ease the pain.

Less common side effects include:

• bleeding
• blistering
• burning or coldness
• discoloration of skin
• hives or rash
• joint infection
• inflammation
• itching or stinging
• lumps
• numbness and tingling
• redness, soreness, and tenderness
• ulceration and warmth at the injection site

People should seek medical attention if they experience mild or more severe reactions.

Knee pain may sometimes go away on its own. If the pain is not severe, a person may be able to treat it at home by:

• putting as little weight as possible on the knee
• avoiding standing for a long time
• using an ice pack on the knee for up to 20 minutes every 2–3 hours
• taking acetaminophen

Learn more about the home remedies for knee pain.

To help prevent knee pain, a person can:

• balance rest and exercise
• maintain a moderate body weight
• wear suitable footwear with arch supports

A person should contact a doctor about knee pain if:

• the pain is severe
• there is swelling in the knee
• there is no improvement after a week
• there is no movement
• the knee cannot bear weight
• the knee locks or buckles

The medication a person receives for knee pain can depend on the cause and severity of the pain.

A person may take OTC medication for mild to moderate pain, such as ibuprofen or naproxen. If the pain is more severe, a person may require medication prescribed by a doctor, such as a higher dose of NSAID or COX-2 inhibitors. A doctor may sometimes administer injections and inject hydrocortisone or hyaluronic acid into the affected area.

A person can also treat knee pain at home by resting, raising the knee, and applying ice.

Osteoarthritis of the knee: | symptoms | preparations

Osteoarthritis is one of the most common joint diseases, accompanied by the destruction of hyaline cartilage. Over time, bones, ligaments and muscles are involved in the pathological process.
Arthrosis of large joints have their own names: hip – coxarthrosis, knee – gonarthrosis.
In the absence of timely medical care, the pathology steadily progresses and becomes the cause of severe pain, a decrease in motor ability. In the absence of adequate treatment, the progression of arthrosis may lead to the need for joint replacement.

Symptoms

One of the first signs of arthrosis is pain in the knee when walking and moving. In the early stages, patients experience discomfort and temporary stiffness after rest. At first, the pain appears periodically and does not have a clear localization, but increases with physical exertion.

In the future, the symptoms become brighter, the range of motion decreases markedly.

Pain syndrome in gonarthrosis is characterized by:

• starting pains in the morning or after a long rest;
• association with physical activity – the knee hurts more when walking, standing or running for a long time. At rest, the pain subsides;
• connection with weather conditions – the pain increases with increasing humidity and atmospheric pressure, cooling;
• blockade of the joint, which is accompanied by sharp pain. Jamming occurs due to the infringement of a fragment of cartilage or bone that has separated from the cartilaginous covering or epiphysis of the bone.

Arthrosis proceeds in waves, exacerbations alternate with periods of remission. Exacerbations cause inflammation of the synovial membrane of the joint, so the nature of the pain changes to constant, aching and arching. She worries both during movement and at rest.

Reasons

Arthrosis does not always have an obvious cause, and then they talk about idiopathic, primary gonarthrosis. The cause of secondary arthrosis can be:

• injury – fractures, dislocations, damage to the meniscus and ligaments of the knee;
• birth defect;
• connective tissue weakness, joint hypermobility;
• autoimmune disease – rheumatoid arthritis, lupus erythematosus;
• infectious and inflammatory process – purulent arthritis, tuberculosis;
• high loads: running and intense squats are especially dangerous for the knees;
• overweight.

Arthrosis of the knee joint: treatment, preparations, injections

Conservative therapy is effective at stages 1-2 of the disease; it is unlikely that surgery can be avoided in the later stages.
Acute symptoms are relieved with non-steroidal anti-inflammatory drugs – Diclofenac, Ibuprofen and their analogues tablets. If NSAIDs do not help, then corticosteroid drugs are prescribed.
Chondroprotectors are used to slow down the degradation of cartilage.
To improve blood supply and nutrition of articular structures, microcirculation improvement agents are used – Normoven, Nicotinic Acid, Cinnarizine, Pentoxifylline.
However, the best treatment for arthrosis today is injection therapy.

Intramuscularly prescribed:

• non-steroids – Flamax, Ketonal, Amelotex, Movalis, Lornoxicam, Diclofenac, Naklofen;
• hormones – Celeston, Flosteron, Diprospan, Hydrocortisone;
• vitamins – Neurorubin, Kombilipen, Milgamma, Trigamma, Compligam.

Hyaluronic acid preparations are prescribed intra-articularly, the frequency of injections and dosage is selected by the doctor based on the diagnosis. Glucocorticosteroids can be administered inside the joint, but they should be prescribed with caution, since with frequent use they can worsen the condition of the cartilage tissue and aggravate the course of arthrosis.

Intra-articular injections

One of the latest developments of Czech scientists is carboxytherapy. It is based on the introduction of carbon dioxide into the joint cavity, which provokes interstitial hypoxia. The gas is supplied through a special device, causing acute oxygen starvation in the articular structures.

The result is a sharp influx of blood to the diseased area and a rapid acceleration of metabolism. Within a few minutes, the gas is removed, and the running mechanism works for a long time.
Another modern method involves the introduction of plasma into the joint – a liquid with blood cells. In this case, plasma with platelets is used, which perfectly relieves inflammation and pain, significantly slowing down the destructive process.

Physiotherapy

Comprehensive treatment of arthrosis of the knee joint includes physiotherapy. They improve local blood circulation, increase range of motion and potentiate the effect of drugs.

The doctor may prescribe:

• SWT – ultrasound – low-frequency currents contribute to the removal of osteophytes;
• magnet – the magnetic field stimulates metabolic processes, thereby accelerating tissue regeneration;
• laser – under the influence of radiation, intracellular metabolic processes are significantly improved, chemical reactions are accelerated, since the laser “works” as a conductor and enhances the effect of other methods of treatment;
• myostimulation – impulse currents restore the natural function of periarticular structures;
• electro-, phonophoresis – the introduction of painkillers or chondroprotective drugs by means of electric current or ultrasound;
• ozone therapy – oxygenation of “weak” places to activate their regeneration.

An important role in the treatment of arthrosis is played by therapeutic exercises, according to indications, massage procedures can be performed.

Operation

Surgical intervention is resorted to in advanced cases, at the 3rd stage of gonarthrosis. Most often, endoprosthesis is performed – today it is the most reliable technique.

After the operation, the body recovers in 3-6 months. Side effects and complications are rare.

There are also organ-preserving operations:

• laser and rehabilitation arthroscopy;
• plasma ablation;
• chondroplasty.

If you are prescribed intra-articular injections, or you need to repeat the course, please contact us. The center provides the service of administering drugs into the joint cavity, manipulations are carried out by experienced doctors of the highest category, so patients feel as comfortable as possible during and after the procedures.

Make an appointment by calling +375 29 628 85 82

Pain-relieving anti-inflammatory knee blockade: what is it?

Drug blockade of the intra-knee joint is a fast and effective method that allows you to relieve pain and stop the acute inflammatory process within a short period of time. This procedure is used in a situation where it is urgent to ensure a long-term effect of medications, relieve inflammation and get rid of pain.

How is a knee block done?

All procedures are performed only in a medical facility by a qualified physician. The injection is administered at the discretion of the doctor – in the inner part of the knee or in the outer. It depends on the nature of the pathological process. After the procedure, you should limit motor activity and minimize joint stress for half an hour. Thanks to this technique, the quality of human life is significantly improved.

The use of therapeutic blockade is advisable to stop pain and get rid of other neurological symptoms. This is an effective method that works within a short period of time. The advantage of this technique is its safety for the body and a minimum of side effects.

With the help of a therapeutic blockade, a three-phase relief of the pain syndrome occurs:

1. Initially, the pain intensifies, since the pain receptors are irritated by the needle.
2. Further, the pain syndrome is reduced to a minimum.
3. In the third phase, a therapeutic effect occurs, the discomfort completely disappears. After the effect of the drug stops, the discomfort returns again, but they are no longer so intense.

Doctors recommend following certain rules after such a procedure – reduce motor activity, immobilize the diseased joint. In advanced situations, the patient needs to immobilize the damaged area for some time.

According to rheumatologists, orthopedists and traumatologists, this technique of direct injection of drugs into the joint cavity or into the periarticular tissues helps to quickly restore a person’s ability to work. It is considered the most effective, especially if you need to provide quick assistance.

The main advantages of this method include:

• the ability to perform repeated impact on the damaged area;
• rapid pain relief;
• minimal risk of developing consequences;
• direct effect on the desired area, drugs are not absorbed into the systemic circulation, the digestive system;
• rapid pain relief;
• the ability to get rid of vascular and muscle spasm, inflammation;
• the procedure can be performed multiple times with each exacerbation;
• the ability to restore trophism in tissues, get rid of puffiness.

The main indications for injections are the following pathological processes:

• synovitis – accompanied by inflammation of the periarticular sac;
• arthritis – reactive, rheumatoid, ankylosing spondylitis;
• serous arthritis – due to trauma, surgery or any other type of damage to the joint;
• bursitis;
• tendovaginitis;
• periarthritis.

Preparations used to block the knee joint

Doctors use local anesthetics to perform the procedure. Consider each drug in more detail.

Novocain

It is injected into nerve fibers or tissues. It has analgesic and antispasmodic effects. In the focus of the disease, a pronounced irritation occurs after the administration of the drug, thus the innervation in the peripheral tissues is significantly reduced. Thanks to this drug, the permeability of the walls of blood vessels decreases, trophism in tissues improves, an antiseptic and bacteriostatic effect is carried out, vascular tone and trophism of nerve fibers improve. This tool is considered one of the safest. It stops the pain syndrome, does not provoke the development of negative reactions.

Lidocaine

This is a local anesthetic. After administration, a long and intense action is provided. After the injection, sodium channels are blocked, as a result, the generation of neuron impulses stops, and their conductivity decreases. The pain syndrome is eliminated, the vessels dilate without irritation. Already 5 minutes after the injection, the severity of unpleasant sensations decreases, the muscle apparatus relaxes.

Bupivacaine

The drug belongs to the amides. It acts slowly, much longer than other drugs. At the same time, the effect of its use is longer. Such a prolonged action is due to a longer half-life, since the active substances are transformed and synthesized not in the blood plasma, but in hepatocytes. The first result can be felt 10-15 minutes after administration.

Hydrocortisone

This is a drug that has a long-lasting effect. It contains synthetic hormonal substances, in their structure they are similar to those substances that the adrenal glands produce. After the introduction of the drug, its active substances accumulate in the tissues, and the inflammatory process stops. This is an inexpensive tool. It is usually used in parallel with Lidocaine. The result is felt within 24 hours after the procedure. The negative consequences after the introduction include an increase in blood pressure. The drug is used in the treatment of neurological diseases.

Dexamethasone

This is a long-acting drug that belongs to the group of glucocorticosteroids. This is a very strong medicine that has a pronounced anti-inflammatory, antihistamine, immunosuppressive effect. It is recommended to use together with anesthetics. The action comes quickly.

Depo-medrol

Has a pronounced prolonged effect. The agent is injected into the synovial cavity of the joint. The procedure should be performed only by a qualified specialist to eliminate the risk of the needle entering large vessels. If there is no effect from the introduction, the second procedure is not performed.

Diprospan

The key active ingredient is betamethasone. After the injection, pain and inflammation are quickly stopped, and allergic reactions are also eliminated. The disadvantage of the drug is its negative effect on the tissues of the adrenal and pituitary glands.

Complex treatment of joints with drugs

Treatment of joint diseases is carried out using the following drugs:

• painkillers. These drugs have a pronounced analgesic effect, but the result after administration is short;
• corticosteroids – Prednisolone, Kenalog, Diprospan. Medicines have a pronounced anti-inflammatory effect, but they cannot be used too often, since there is a danger of developing dystrophic-degenerative processes in the joint;
• chondroprotectors – Fermatron, Alflutop, Ostenil, in combination with hyaluronic acid help to replenish the lack of joint fluid;
• vitamin preparations – Milgamma. The medicine improves tissue nutrition, helps them recover.

Painkillers

Painkillers most commonly used for joint blockade include Novocaine, Lidocaine, Trimeacaine. After their introduction, the pain syndrome is quickly stopped, the severity of the inflammatory process decreases.

The advantage of such drugs is that they directly affect the focus of the pathological process. Negative reactions practically do not develop, since drugs are not absorbed into the systemic circulation and into the digestive system. In addition to eliminating pain, such drugs reduce the severity of muscle tension, relieve vascular spasm and swelling.

Blockade of the knee joint with Diprospan

Betamethasone is the key active ingredient in the medicinal product. This drug is used in the treatment of many articular pathologies. After the introduction, the result is felt after 3-4 hours. The duration of action is one month. When injecting, it is not required to anesthetize the injection area.

Diprospan is not only a powerful effective analgesic and anti-inflammatory agent, it is also a safe drug that is rarely capable of provoking adverse reactions. When used correctly, the medicine is safe for the body.

Novocaine blockade of the knee

Novocaine blockade is an innovative method that is used to treat various pathological processes in the articular apparatus. The mechanism of action is that the active substances of the drug temporarily stop the processes of innervation in the diseased joint. The medicine is administered by injection directly into the affected tissues that surround the joint or nerve.

This is a local anesthetic and works only when administered locally. The result comes within a short period of time. The pain is eliminated for an hour.

Novocaine acts according to the following principle:

• the drug is an antiseptic and bacteriostatic, inhibits the growth and development of pathogens;
• increases the body’s resistance to allergens;
• reduces the permeability of the vascular walls;
• evens out vascular tone;
• quickly relieves spasm in smooth muscles;
• improves trophism in nerve fibers.

Novocaine actively affects the autonomic nervous system. Adverse reactions after drug administration are minimal. This is a safe remedy that quickly relieves pain and reduces the likelihood of developing negative consequences of the inflammatory process.

The key indications for novocaine blockade are:

• pain, regardless of the nature and location, which cannot be stopped by other methods;
• acute inflammatory processes in soft tissues;
• injuries or injuries of various groups of joints;
• burns, frostbite, snake bites;
• decreased tone of internal organs.

Lidocaine knee blockade

Lidocaine is a local anesthetic. It provides a longer and more intense effect than other types of painkillers. Used as hydrochloride. After the introduction, the voltage-gated sodium channels are blocked. As a result, the generation of impulses in neurons stops, innervation is blocked.

Lidocaine eliminates pain and expands the walls of blood vessels.