What are Cyanocobalamin injections used for. How do Vitamin B12 shots work. What are the potential side effects of B12 injections. Who might benefit from Cyanocobalamin treatments. How is Vitamin B12 administered intramuscularly.

Understanding Cyanocobalamin: A Synthetic Form of Vitamin B12

Cyanocobalamin is a man-made version of vitamin B12, an essential nutrient crucial for various bodily functions. This synthetic form is commonly used in medical treatments to address vitamin B12 deficiencies and related health issues. But what exactly is Cyanocobalamin, and how does it work in the body?

Cyanocobalamin plays a vital role in several physiological processes:

• Helps the body utilize fats and carbohydrates for energy production
• Supports the creation of new proteins
• Contributes to normal blood cell formation
• Maintains healthy nerve function

While most individuals obtain sufficient vitamin B12 through their diet, certain conditions can lead to deficiencies, necessitating supplementation through injections or other forms of treatment.

The Medical Uses of Cyanocobalamin Injections

Cyanocobalamin injections are primarily prescribed to treat vitamin B12 deficiencies. These deficiencies can arise from various health conditions and lifestyle factors. But when are these injections typically recommended?

Common scenarios where Cyanocobalamin injections may be prescribed include:

1. Pernicious anemia
2. Malabsorption disorders
3. Strict vegetarian or vegan diets
4. Certain gastrointestinal surgeries
5. Chronic alcoholism

In cases of severe vitamin B12 deficiency, individuals may experience symptoms such as anemia, gastrointestinal issues, and neurological problems. Cyanocobalamin injections can help alleviate these symptoms and restore optimal vitamin B12 levels in the body.

Administration and Dosage of Vitamin B12 Shots

Cyanocobalamin injections are typically administered intramuscularly or subcutaneously. The dosage and frequency of injections can vary based on individual needs and the underlying cause of the deficiency. How are these injections typically given?

The administration process generally involves the following steps:

1. A healthcare professional determines the appropriate dosage based on the patient’s condition and response to treatment.
2. The injection site is cleaned and prepared.
3. The medication is injected into a muscle (intramuscular) or under the skin (subcutaneous).
4. The injection site is monitored for any immediate reactions.

For those using Cyanocobalamin at home, proper training from a healthcare provider is essential to ensure safe and effective administration.

Potential Side Effects and Precautions

While Cyanocobalamin injections are generally considered safe, like any medication, they can cause side effects in some individuals. What are the most common side effects associated with B12 shots?

Common side effects may include:

• Pain or redness at the injection site
• Mild diarrhea
• Itching
• A feeling of swelling throughout the body

In rare cases, more serious side effects can occur. These may include severe allergic reactions, low potassium levels (hypokalemia), or complications in individuals with certain pre-existing conditions such as polycythemia vera.

Precautions and Contraindications

Before starting Cyanocobalamin treatment, it’s crucial to inform your healthcare provider about any allergies, medical conditions, or medications you’re taking. Certain factors may influence the suitability of B12 injections for an individual:

• Allergies to cobalt or other components of the medication
• History of low potassium levels
• Kidney disease
• Leber’s disease (a rare eye condition)
• Pregnancy or breastfeeding

Your doctor may recommend a small test dose before beginning regular treatment to assess your body’s response to the medication.

Interactions with Other Medications

Cyanocobalamin can interact with certain medications, potentially altering their effectiveness or increasing the risk of side effects. Which medications might interact with B12 injections?

While not an exhaustive list, some medications that may interact with Cyanocobalamin include:

• Metformin (used to treat diabetes)
• Proton pump inhibitors (used to reduce stomach acid)
• Colchicine (used to treat gout)
• Antibiotics such as chloramphenicol

It’s essential to provide your healthcare provider with a complete list of all medications, including over-the-counter drugs and herbal supplements, to prevent potential interactions.

The Benefits of Cyanocobalamin Injections

When used appropriately, Cyanocobalamin injections can offer significant health benefits for individuals with vitamin B12 deficiencies. What improvements might one expect from B12 treatment?

Potential benefits of Cyanocobalamin injections include:

• Improved energy levels and reduced fatigue
• Enhanced cognitive function and mood
• Better cardiovascular health
• Improved nerve function and reduced risk of neurological complications
• Healthier skin, hair, and nails

For individuals with pernicious anemia or other conditions causing severe B12 deficiency, these injections can be life-changing, dramatically improving overall health and quality of life.

Monitoring and Long-term Management

For many individuals, Cyanocobalamin injections may be a long-term treatment. How is the effectiveness of B12 therapy monitored over time?

Long-term management of vitamin B12 therapy typically involves:

1. Regular blood tests to assess vitamin B12 levels and overall health markers
2. Adjustments to dosage or frequency of injections based on individual response
3. Ongoing assessment of symptoms and potential side effects
4. Evaluation of dietary habits and potential causes of deficiency

Your healthcare provider will work with you to determine the optimal treatment plan and make any necessary adjustments over time.

Alternative Forms of Vitamin B12 Supplementation

While Cyanocobalamin injections are highly effective, they’re not the only option for addressing vitamin B12 deficiencies. What other forms of B12 supplementation are available?

Alternative forms of vitamin B12 supplementation include:

• Oral tablets or capsules
• Sublingual (under the tongue) tablets or drops
• Nasal sprays
• Transdermal patches

The most appropriate form of supplementation depends on individual factors such as the severity of the deficiency, underlying health conditions, and personal preferences. Your healthcare provider can help determine the best option for your specific needs.

Dietary Sources of Vitamin B12

For individuals without absorption issues, dietary sources of vitamin B12 can help maintain adequate levels. Rich sources of B12 include:

• Animal products such as meat, fish, and dairy
• Fortified cereals and plant-based milk alternatives
• Nutritional yeast
• Some varieties of seaweed (though not a reliable source)

Vegetarians and vegans may need to pay special attention to their B12 intake and may benefit from regular supplementation.

The Future of Vitamin B12 Therapy

As medical research progresses, new developments in vitamin B12 therapy continue to emerge. What advancements might we see in the future of B12 supplementation?

Potential areas of development include:

• More efficient delivery methods for B12 supplementation
• Improved diagnostic tools for early detection of deficiencies
• Better understanding of the role of B12 in various health conditions
• Development of longer-acting formulations requiring less frequent administration

These advancements could lead to more personalized and effective vitamin B12 treatments in the future.

Cyanocobalamin injections represent a crucial treatment option for individuals suffering from vitamin B12 deficiencies. By understanding the uses, benefits, and potential side effects of this therapy, patients can work more effectively with their healthcare providers to manage their health and well-being. As with any medical treatment, it’s essential to consult with a qualified healthcare professional before starting or changing any vitamin B12 supplementation regimen.

Cyanocobalamin (Vit B-12) Injection: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

Cyanocobalamin is a man-made form of vitamin B12 used to treat low levels (deficiency) of this vitamin. Vitamin B12 helps your body use fat and carbohydrates for energy and make new protein. It is also important for normal blood, cells, and nerves. Most people get enough vitamin B12 in their diet, but a deficiency may occur in certain health conditions (such as poor nutrition, stomach/intestinal problems, infection, cancer). Serious vitamin B12 deficiency may result in anemia, stomach problems, and nerve damage.

How to use Cyanocobalamin (Vit B-12) 1,000 Mcg/Ml Injection Solution

If you are using this medication at home, learn all preparation and usage instructions from your health care professional.

Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid.

This medication is given by injection into a muscle or under the skin as directed by your doctor.

Dosage is based on your medical condition and response to treatment. Injections may be given daily when you first start treatment. Certain medical conditions (such as pernicious anemia) may require you to continue receiving injections every month.

Learn how to store and discard needles and medical supplies safely. Consult your pharmacist.

Side Effects

Pain/redness at the injection site, mild diarrhea, itching, or a feeling of swelling all over the body may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may cause low potassium levels in the blood (hypokalemia). Tell your doctor right away if any of these serious side effects occur: muscle cramps, weakness, irregular heartbeat.

People who have a rare blood disorder (polycythemia vera) may rarely have symptoms related to this disorder while taking cyanocobalamin. Get medical help right away if any of these very serious symptoms occur: chest pain (especially with shortness of breath), weakness on one side of the body, sudden vision changes, trouble speaking.

Get medical help right away if you have any very serious side effects, including: symptoms of heart failure (such as shortness of breath, swelling ankles/feet, unusual tiredness, unusual/sudden weight gain).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before using cyanocobalamin, tell your doctor or pharmacist if you are allergic to it; or to cobalt; or if you have any other allergies. Your doctor may recommend that you receive a smaller test dose before starting your regular dose. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: low potassium blood levels (hypokalemia), gout, kidney disease, a certain blood disorder (polycythemia vera), a certain eye disease (Leber’s disease), other vitamin/mineral deficiencies (especially folic acid and iron).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

Based on information from related drugs, this medication may pass into breast milk. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

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Overdose

Overdose with this medication is very unlikely. However, if someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Do not share this medication with others.

Lab and/or medical tests (such as blood potassium levels, complete blood count, hematocrit, vitamin B12 levels) should be done while you are using this medication. Keep all medical and lab appointments. Consult your doctor for more details.

This product is not a substitute for a proper diet. Remember that it is best to get your vitamins from healthy foods. Vitamin B12 is commonly found in many foods from animals, especially liver, kidney, fish and shellfish, meat, and dairy foods.

It is important to get each dose of this medication as scheduled. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not freeze. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Types of Vitamin B12 Injections and Benefits

VITAMIN B12 INJECTIONS

Vitamin B12 mainly supports proper functioning of the brain, nervous system and the production of blood. It is also contributes to optimal functioning of various other aspects of the brain and nervous system, and its consumption supports memory and other cognitive functions. In relation to blood, B12 is a key component for the production of hemoglobin, which carries oxygen to your cells through your blood. In addition to overall health benefits, this process is important for maintaining sufficient energy levels.

Orally B12 absorption is highly depend on the digestive system. The stomach produces a protein called intrinsic factor. If your stomach is not making enough intrinsic factor due to digestive issues such as gastritis, surgery, consuming too much MSG, weak stomach acid or a multitude of other factors, it is difficult for the body to absorb the B12 that it needs.

Other factors such as diet will affect overall B12 levels in the body.

Vitamin B12 deficiency symptoms include: depression and mood disorders, fatigue, problems with memory, anemia, low blood pressure, and high homocysteine levels.

B12 supplementation can be achieved orally or via other means such as intramuscular injections.

BENEFITS OF B12 INJECTIONS INCLUDE:

Increases Energy

Boosts Immune System

Increases Metabolism and Assists in Weight Management

Improves Mood and Metal Alertness

Combats Stress and Irritability

THERE ARE TWO MAIN TYPES OF VITAMIN B12 MOST COMMONLY USED IN INJECTIONS: CYANOCOBALAMIN AND METHYLCOBALAMIN.

What is the difference:

Methylcobalamin

This is the most useable and active form in the human body. It converts homocysteine into methionine, which helps protect the cardiovascular system. Methylcobalamin also offers overall protection to the nervous system. This B-12 form can also cross the blood-brain barrier ((a highly selective permeability barrier that separates the circulating blood from the brain extracellular fluid) – without assistance–to protect brain cells. It contributes essential methyl groups needed for detoxification and to start the body’s biochemical reactions.

Cyanocobalamin

This synthetic version of vitamin B12 is created in a lab, which makes it the least expensive supplement option. It offers the most stable form of B12, although it does so through the presence of a cyanide molecule. While the amount of cyanide is not dangerous, it does require the body to expend energy by taking a methyl group and forcing the liver to dispose of the cyanide molecule.

All of the B12 and B12 Combinations at GLO use Methylcobalamin as the source of B12. For several reasons: 1. It does not contain cynanide 2. Research has shown that it remains in the body for a longer period of time and at higher levels than cyanocobalamin, which means that your body is supplied with vitamin B12 for longer if you use methylcobalamin than if you use cyanocobalamin. 3. It provides additional benefits such as reduces nerve pain, improves irritability, stress and anxiety.

B12 MIC INJECTIONS

​Backed by clinical science, and when administered in accordance with a low calorie diet and routine exercise B12 Methionine Inositol Choline (MIC) Injections work to support weight loss. This formula consists of a blend of lipotropic, i.e. fat mobilizing amino acids, which are capable of: enhancing liver function by assisting in the metabolism of fat cells; aiding in the prevention of cholesterol buildup; and helping to remove debilitating toxins from your liver. L-methionine is an amino acid, inositol and choline are cofactors, and together they aid in the elimination of abnormal fat cell deposits. Additional research shows, that when these lipotropic agents are further combined with vitamin B12 injections the synergy created provides exceptional fat burning throughout the entire body.

Background

B12 Methionine Inositol Choline (MIC) Injections, also referred to as Lipo Injections, are used to help release fat throughout the body by specifically targeting its primary fatty deposits, namely the stomach, inner thighs, neck, buttocks, hips, and underarms. Lipotropic, or fat burning substances include: inositol, which helps the liver remove fat; choline, which distributes cholesterol and prevents it from getting deposited in one part of the body; and methionine, which is similar to inositol, but also amplifies the combination. Injections can be administered up to twice a week, and vitamin B12 is purported by practitioners and users to help accelerate metabolic processes, while creating a greater feeling of overall energy. Since lipotropics directly aid in the breakdown of fatty tissue, and are also closely related to B vitamins, when used together, they are thought to intensify each others’ effects and are usually injected together as part of the same treatment injection cycle.

HOW B12 MIC INJECTIONS WORK

The amino acids that are injected into the body stimulate the liver into optimizing the process of metabolism. These injections boost the body’s metabolic power by providing a highly effective temporary increase of normal metabolic functions. As soon as the effect of these substances wears off, the body begins to gradually return to its normal metabolic rate. When administered in combination with a low-calorie diet and regular exercise, lipotropic formulas can help your body to rid itself of fat, while simultaneously increasing your energy levels both via the fat released energy and the energy promoting properties of vitamin B-12. The formula used in the MIC Injection specially blends the following important ingredients:

Methionine – The “M” in B12 MIC Injection, is an essential amino acid, which means that it is not synthesized in humans. This amino acid acts as a lipotropic agent which: assists in the breakdown of fats within the liver; helps to lower cholesterol thereby preventing excess fat buildup in the liver and throughout your body’s circulatory system; is helpful in preventing and relieving fatigue; and is useful in some cases of allergies by virtue of its ability to reduce histamine release.

One of the sulfur-containing amino acids (along with cysteine and cystine), methionine is important (essential) to many bodily functions and must be directly consumed through supplementation or methionine-containing proteins. Foods which contain high levels of methionine include cheese, eggs, fish, meats, spinach, potatoes, Brazil nuts, sesame seeds, and select other plant seeds. However, by injecting methionine into your muscles you can rapidly achieve high concentrations which many researchers and physicians believe results in more effective mobilization and elimination of abnormal fatty deposits. Other reported benefits of methionine include improvement of: liver disease; skin tone and elasticity; nails; hair; and cardiovascular and muscular functions, through its role in the production of creatine. It has also been used to treat premature ejaculation, chronic depression, pancreatitis, Parkinson’s disease, and AIDS myelopathy. More specifically, clinical research has clearly demonstrated methionine’s ability to “…strongly improve the alcohol-induced histological changes in the liver. Triglyceride content of the liver was found to decrease in a dose-dependent manner with increasing methionine ingestion.

Inositol – The “I” in B12 MIC Injection, is a B-vitamin that promotes: the health of cell structures and nerve synapses; aids in the metabolism of fats; helps reduce blood cholesterol; and participates in the action of serotonin, a neurotransmitter known to control mood and appetite.

Also known as myo-inositol, inositol is best described as a carbocyclic polyol, which forms the basis for many signaling and secondary messenger molecules. As such, it is involved in many biological processes, including the breakdown of fats, the reduction of serum cholesterol, serotonin activity modulation, gene expression, and insulin signal transduction. It is not considered a vitamin because your body is unable to synthesize it. However, it has been shown to be helpful for the treatment of depression, panic disorder, polycystic ovarian syndrome, and fatty liver. It also important for optimal brain function.

Inositol deficiency may manifest as symptoms of constipation, high cholesterol, vision problems, and hair loss. Although it is naturally found in certain foods such as nuts, beans (especially red beans and kidney beans), grains, cantaloupe melons, and oranges, it is more effective in breaking down fat when given as an intramuscular injection.

Choline – The “C” in B12 MIC Injection, is an essential nutrient that helps to support the liver in its processing and excretion of chemical waste products. Moreover, it is required for the transport and metabolism of fats and cholesterol, which is important for the healthy support of the endocrine, cardiovascular, and hepatic systems.

A few specific studies have clearly demonstrated:

“Choline supplementation normalized cholesterol metabolism, which was sufficient to prevent nonalcoholic steatohepatitis development and improve liver function. Our data suggest that choline can promote liver health by maintaining cholesterol homeostasis.”
“Choline induces glucose and insulin intolerance in Pemt(-/-) mice through modulating plasma glucagon and its action in liver.”
Choline supplementation decreased the concentration of liver triacylglycerol during the first 4 wk after parturition. Results from this study suggest that hepatic fat export in periparturient dairy cows is improved by choline supplementation during the transition period and this may potentially decrease the risk for metabolic disorders in the periparturient dairy cow. ”
Choline is also known to be involved in the synthesis of carnitine, cell membrane phospholipids, and the neurotransmitter acetylcholine. It is a major source for methyl groups via its metabolite trimethylglycine (betaine) that participates in the S-adenosylmethionine synthesis pathways. Lastly, choline has also been shown to specifically aid with memory, and to support the maintenance of a healthy nervous system. Food sources of choline include peanuts, soybeans, wheat, chicken, fish, beef, cauliflower, eggs, and lettuce.

Methylcobalamin (Vitamin B12) – This form of B12 vitamin is used in the B12 MIC injections and plays a significant role in the replication of DNA, the normal functioning of the nervous system, and the formation of blood cells. The vitamin B12 injection has been shown to provide these key benefits: boosts energy and overall metabolic rate; assists in the burning of stored body fat; detoxifies the body; increases red blood cell production; maintains a healthy liver; helps regulate sleep, mood, appetite and energy; works synergistically with other nutrients to improve health; and slows aging.

Vitamin B12 is frequently used in combination with other B vitamins in a vitamin B-complex formulation. Important in DNA synthesis, vitamin B12 is bound to the protein in food, and is released by stomach acids during digestion. Once released, B-12 combines with a substance called intrinsic factor (IF) before it is absorbed into the bloodstream. Essentially water-soluble this vitamin is commonly found in a variety of foods such as fish, shellfish, meat, eggs, and dairy products.

HIGH B COMPLEX

Ingredients: Methylcobalamin 1 mg/mL, Niacinamide, Pyridoxine, Dexpanthenol, Thiamine, Riboflavin, Lidocaine

When used in combination with B12-MIC injections High B Complex injections pack nutrients into one powerful formula, created to cut through fat, energize the body, and fight brain fog and fatigue. Even dangerous visceral fat that wraps around the heart, liver, kidneys, and pancreas can be eliminated through diet, exercise, and B complex injections. By harnessing the power of the body’s natural fat burning capabilities; this can helps patients begin to build lean muscle mass, sculpt and tone problem areas, and convert calories into energy, efficiently and effectively.

B12- Methylcobalamin

This renowned vitamin can help boost your weight loss and improve your quality of life. Your body cannot produce this B12 itself, so you need to supplement with it to get the fat metabolization and energy production benefits it has to offer. It can help you beat the fatigue, improve mental focus, and level out some blood, gastrointestinal, and psychiatric disorders. B12- benefits can include- increased energy, improved immune system, increased metabolism, weight loss assistance, improved mental alertness, increased stamina, relief from stress, anxiety and pms.

Thiamine B1

This vitamin is important because it ensures that the food you eat gets used for energy. It has astounding effects on your adenosine triphosphate (ATP) levels that help to make cells more productive and useful in the body. The results: Less fat storage and more energy at the cellular level.

Dexpanthenol ( Pantothenic Acid- B5)

Vitamin B5 is needed for the metabolism of carbohydrates, proteins, and fats. It is also involved in the creation of hormones and cholesterol. .

Riboflavin B2

Helps with energy production that benefits to stimulate weight loss. In addition to making sure fat cells are being metabolized, it also helps to make iron more proficient in the body and offers antioxidant attributes in ridding the body of harmful toxins.

Niacinamide B3

This vitamin is essential for all organs at the cellular level. With Vitamin B3 in the mix, you’re looking at making sure that damaged DNA cells are not only being repaired, but protected. Fat and bile are harmful to the body in more ways than just putting on the pounds. You’ll be getting cardiovascular and immune support while its “B” traits continue in the fat metabolism department.

Pyridoxine B6

Getting enough of this family member can help make all the other B vitamins more effective and useful in the body. Not only is it going to work to ensure that systemization of adipose tissue is underway, it’s also ensuring that your brain and signals are functioning properly so you can experience the euphoria of losing all that weight. B6 helps to promote improved mental alertness, clarity, and concentration.

References:
1. Shibuya K, Misawa S, Nasu S, Sekiguchi Y, Beppu M, Iwai Y, Mitsuma S, Isose S, Arimura K, Kaji R, Kuwabara S. Safety and efficacy of intravenous ultra-high dose methylcobalamin treatment for peripheral neuropathy: a phase I/II open label
clinical trial. Intern Med. 2014;53(17):1927-31. Epub 2014 Sep 1. PubMed PMID: 25175124.

2. Spence JD. B vitamin therapy for homocysteine: renal function and vitamin B12 determine cardiovascular outcomes. Clin Chem Lab Med. 2013 Mar 1;51(3):633-7. doi: 10.1515/cclm-2012-0465. PubMed PMID: 23449527.

3. Takahashi K, Okawa M, Matsumoto M, Mishima K, Yamadera H, Sasaki M, Ishizuka Y, Yamada K, Higuchi T, Okamoto N, Furuta H, Nakagawa H, Ohta T, Kuroda K, Sugita Y, Inoue Y, Uchimura N, Nagayama H, Miike T, Kamei K. Double-blind test on the efficacy of methylcobalamin on sleep-wake rhythm disorders. Psychiatry Clin Neurosci. 1999 Apr;53(2):211-3. PubMed PMID: 10459691.

4. zliving.com

5. globalhealingcenter.com

6. methylcobalamininfo.com

7. hrt.org/vitamin-b-complex-injections-using-lipo-b-vitamins-weight-loss

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In 2023, the kral puncher series, caliber, huntsman, ataman and kral are the most popular. In addition to the sale itself, we provide repair, tuning and maintenance services for pneumatics in an official workshop. You can always install optics (including hunting monoculars), shoot and tune a PSP rifle. In addition, more than 5700 items of accessories are available – cartridges, bullets, pumps, cylinders, valves, filling stations and other necessary products. All this can be purchased, in a ready-made kit and without overpayment. By the end of the year, it is expected to expand the bullpup kits, optical sights, as well as the range of pumps to increase pressure in cylinders. We work 7 days a week, seven days a week and ship products throughout Russia. Express delivery in Moscow is possible, as well as pickup from the showroom. We also have items for Reloading.

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Will power. And where is her brain hiding? / Habr

Before you is the final race. There are eight athletes on the track, their feet rested on the starting blocks. The voice of the referee is heard over the stadium: “To the start!”, “Attention!”, And a split second before the shot, one runner takes off and gets disqualified. It is at such moments that it is important to suppress the craving for action. RISE is in touch: community about nootropics and personal productivity. So how do you fix and grow endurance in yourself?

Good and bad cops will tell you what willpower is

Different approaches, but one goal

Moving towards new habits, we often balance between internal motivation and external incentives. Something from the inside makes us do a little more: kill the boss in the game in a special way, buy a smartphone of a certain model, or drive at a dangerous section of the road at speed. And something from the outside forces you to get up at 6 in the morning, perform routine tasks and pay bills. And here it is worth looking a little deeper.

External stimulation

Simple, intelligible, unpleasant

Our life is quite diverse. However, it often contains things that we want to do and things that we have to do in order to achieve something. Pelevin showed this very exaggeratedly and aptly in the book “Love for the Three Zuckerbrins”, when a resident of a brave new world was forced to endure weekly torments in order to gain access to pleasant sensations.

But there is nothing absolutely bad or good in the world. Stimulation encourages us to fight for survival, overcome difficulties and reach new heights, despite obstacles and vicissitudes of life. And cortisol, adrenaline and norepinephrine help her in this, literally kicking her body into reacting to external events.

Willpower allows us to understand and accept the fact that we literally “must” act. Otherwise, inaction will turn into much bigger problems. At this moment, something turns on in the head, and we begin to solve the problem, having passed, after grandfather Freud, 5 stages of acceptance. Sometimes, for a successful passage, we need not only a resource, but also the ability to accept our weaknesses and the strength of external circumstances. What the Philosophical School of Stoicism talks about.

Intrinsic motivation

Here everything is clear and without a signature. When desires, goals and opportunities are added in one right direction

A more pleasant and interesting state for the body. Emotions overflow, the anticipation of the award draws new perspectives, and we voluntarily do interesting work for us. Fast, efficient, and not quite in the way that client-bosses expect.

• Intrinsic motivation is not willpower. This is an open resource that literally cuts off external irritating factors, and allows you to move without feeling tired, exhausted or in pain.

• The process is controlled by dopamine and serotonin. The first provides a sense of anticipation. The second is allocated in response to the achievement of the reward. A separate material on Habré in more detail describes the work of dopamine and its essence .

• Dopamine and serotonin do not draw out the constant control of the body. In this case, we would completely lose interest in vital functions and become dopamine addicts who endlessly scroll the news feed …

Intrinsic motivation makes life more enjoyable. Thanks to her, we can relax, rest, receive those crumbs of happiness that life has given us. Great things happen at the peak of strength, when the body is destroyed, but performs the task. But it is motivation that gives the spark of ignition, thanks to which we take the first step.

Discipline or a third is not superfluous

Who doesn’t know this disciplined and purposeful Belarusian?

In matters of motivation and stimulation, a person has found a third way. It is not for nothing that we have developed a neocortex, which makes it possible to explain the causes of incentives and concretizes the moments of receiving a reward. It is thanks to the neocortex that we can extrapolate the consequences of events. And adjust behavior patterns.

Motivation gives us a spark, but not fuel for work. Stimulation allows you to avoid critical risks, but eats away the resources of the body. Balancing between the two extremes allows discipline and unconditional habits.

Some coaches and trainers say that you need to develop creativity. Walk different roads, shave and brush your teeth with your left or right hand, delight yourself with new dishes. On the other hand, there is a minimalistic approach. Say, everything that you can entrust to the autopilot of the body – entrust. Free up resources for the really important things. This is true for workflows, especially when it comes to digital minimalism .

And if you follow the path of discipline and endurance, momentary impulses become a problem. How to maintain self-control and not succumb to provocations from outside? How can the brain protect us from temptations? The main thing is to give him the necessary nutrition.

We feed the brain so that willpower grows

Not so, of course. But who knows what will happen at the Singularity

Willpower, the state of flow, the ability to cope with stress – all this is what our brain can do. But for this he needs components. One of them is magnesium, about which we wrote in this material . But, there are others. They can be roughly divided into three groups. Elements of each of them are freely available, and I’m sure you’ve come across each of the components.

Here and now drugs

• Caffeine . Needs no introduction. We extract it as standard, from cups with fragrant black liquid. And no, the movie “Prometheus” has absolutely nothing to do with it. Coffee, by the way, reflects the very principle of motivation. This is the spark to start, but not the main fuel. By the way, here is the material on whether there is a perfect coffee and how to brew it.

• L-theanine. Practically useless if taken alone. But it shows itself much better in conjunction with caffeine. In particular, we can consider an interesting study that used a placebo control group. It confirmed that co-administration of caffeine with theanines (160 and 200 mg) significantly increased the neurophysiological signs of concentration. Compared to individual medications. Separately, you can read a large review article, dedicated entirely to theanine .

• L-Tyrosine. A fairly promising substance that has a positive effect on motivation, memory and concentration . A separate advantage is the emphasis on increasing resistance to stress and on a general decrease in anxiety.

• Rhodiola rosea. If you’re looking at adaptogens, is the most effective of them all. Tangible changes occur after the first dose and persist for a period of 4-6 hours. If you suffer from chronic fatigue, you will get the opportunity to live for a while without it.

Accumulative products

• DMAE. Helps the brain produce more acetylcholine. It is a key substance for the growth of new neuro-structures. At the same time, it preserves the structure and functioning of pre-created neural networks. Research .

• Bacopa Monnieri. Popular for its bacoside content. It is bacosides that induce dephosphorylation of membranes with a subsequent increase in protein turnover in brain cells. Thus, they stimulate nerve cells, participate in the regeneration and restoration of damaged neurons. It is thanks to the bacosides of Bacopa Monnieri that it promotes the synthesis and restoration of damaged neurons, restoration of synaptic activity and transmission of nerve impulses.

General fuel for the central nervous system and brain

It includes a complex of B vitamins. Used in different forms, with different ratios. If the previous components are aimed primarily at the brain, then this element has a general effect on the body as a whole.

You can select these components optionally, on the same Ozone, or in sports nutrition stores. I prefer their combination in complex Mind Booster . Tested by repeated courses of taking, and the jar is beautiful, which has a positive effect on the release of serotonin 😉

Willpower in a particular situation

When we choose between what is easy and what is right

The study of willpower began with the attention of researchers to Parkinson’s and Huntington’s diseases. Both disorders are marked by movement disorders with radically opposite symptoms. Patients with Huntington’s disease suffer from uncontrolled, involuntary movements. And patients with Parkinson’s disease must make significant efforts to perform at least some purposeful action. Remarkably, both disorders are associated with dysfunction in the same area of ​​the brain: the basal ganglia. The question arises: how is the same part of the brain involved in such contradictory functions?

Challenging problem

Two entities of the same process

Study author Joe Paton started with the accumulated data from previous studies. In them, scientists have identified two main circuits in the basal ganglia. Their Contours were named: direct and indirect paths. It is believed that while the activity of the direct path promotes movement, the indirect path inhibits it. However, the exact manner in which this interaction is carried out was unknown.

Scientists set about solving the problem by radically changing the approach to conducting such experiments:

• Previous studies have looked at how the basal ganglia function during movement. Paton’s team focused on processes that should suppress active actions.

• The team devised a task in which mice followed the pause between beeps. The mice had to determine if the pause was longer or shorter than 1.5 seconds. If the pause was shorter, the reward was given to the left, and if it was longer, then the reward was given to the right.

• The key was that the mouse had to remain still between signals. Therefore, even if the animal was sure that the 1.5 second mark was passed, it had to suppress the urge to move until the second signal sounded. And after that go for the reward.

In the video below, the authors of the study explain what was done and how. If you speak English, welcome.

It’s time to delve into the insides

The researchers tracked neural activity in both pathways while the mouse performed the task. The readings were exactly the same as in previous studies, but only while the mouse was moving. During the period of suppression of actions, the situation changed diametrically.

Interestingly, in contrast to the coactivation that the researchers observed during movement, the activity patterns of the two pathways were strikingly different during the period of inhibition. The activity of the indirect pathway was generally higher and increased steadily as the mouse waited for the second beep.

According to the authors, this observation suggests that the indirect pathway flexibly supports the animal’s behavioral goals. As time passes, the mouse becomes more confident that it is in the “long interval” stage. And so her desire to move is harder to contain. It is likely that this continuous increase in activity reflects an internal struggle.

Inspired by this idea, Bruno Kruse, a graduate student in the laboratory, tested the effect of indirect pathway inhibition. This manipulation made the mice behave more impulsively, causing the mice to rush to the reward port prematurely. This is how scientists discovered the “impulsive switch.”

This discovery has wide implications. The results can be used when working with patients with Parkinson’s and Huntington’s. It also provides a unique opportunity to explore impulsive behavior, addictions and obsessive-compulsive disorders.

Digging Deeper

So scientists have identified a region of the brain that actively suppresses the urge to act, but where does the urge come from? It was written above that there are two ways: direct and indirect. And if the activity of the indirect path is blocked, then it occurs in the direct path? No matter how! The behavior of the mouse remained virtually unchanged when the researchers inhibited the activity of the direct pathway.

We knew that the mice had a strong urge to act. This was confirmed by the fact that suppression of the indirect path contributed to impulsive behavior. But the source of the activity remained unknown. To determine it, we used computational modeling. We used the accumulated knowledge about the basal ganglia, formulated their mathematical model and tested how this system processes information. We then compared the behavior of the model with data from previous studies and identified a new candidate: dorsomedial striatum.

Joe Paton, Head of Research.

The hypothesis turned out to be correct. Inhibition of neurons direct pathway in this area changed the behavior of the mouse. Both of the areas the scientists studied are located in a part of the basal ganglia called the striatum. The first area is responsible for “low-level” motor-sensory functions, while the second area is responsible for “high-level” functions, such as decision making.

Willpower, it’s not about the decision-making center, but about the competition between motives

The authors argue that their results contradict the general understanding of how the basal ganglia work. Now it is assumed that this is a source of commands, a kind of activity control center. However, the new model offers a different perspective on how the basal ganglia work.

Our research shows that there are potentially separate neural circuits in the brain that constantly compete for what action to perform at the next moment in time. This knowledge is important for a deeper understanding of how this system works. Of course, this will help in the treatment of movement disorders. But the potential for discovery extends much further. Observations in the field of neuroscience are at the heart of many methods of machine learning and artificial intelligence. The idea that decision-making can occur through the interaction of many parallel circuits in the same system can be useful for developing new types of intelligent systems.

Joe Paton, Head of Research.

The output is quite simple . Our brain really looks like a giant orchestra, the work of which depends on the overall coordination of all areas. Therefore, “using the brain 100%” is more about organizing harmonious nutrition for its structures.