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Benadryl and Restless Legs Syndrome: What You Need to Know

by alexxlab

How does Benadryl affect restless legs syndrome. Can antihistamines worsen RLS symptoms. What medications should people with RLS avoid. How can RLS symptoms be managed naturally.

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Understanding Restless Legs Syndrome (RLS)

Restless Legs Syndrome (RLS) is a neurological disorder characterized by an irresistible urge to move the legs, often accompanied by uncomfortable sensations. These symptoms typically worsen during periods of rest or inactivity, particularly in the evening or at night, making it difficult for sufferers to relax or sleep.

RLS affects millions of people worldwide, with varying degrees of severity. The condition can significantly impact quality of life, disrupting sleep patterns and causing daytime fatigue. Understanding the triggers and potential treatments for RLS is crucial for those affected by this condition.

The Link Between Benadryl and RLS

Benadryl, a popular over-the-counter antihistamine containing diphenhydramine, has been associated with worsening RLS symptoms in some individuals. While scientific research on this specific link is limited, anecdotal evidence and expert opinions suggest a correlation.

The National Institute of Neurological Disorders and Stroke advises that diphenhydramine may exacerbate RLS symptoms. This is particularly concerning given that many people use Benadryl as a sleep aid, unaware that it could potentially disrupt their sleep further if they are prone to RLS.

Why Does Benadryl Affect RLS?

The exact mechanism by which Benadryl worsens RLS symptoms is not fully understood. However, it is believed that the sedating properties of diphenhydramine may interfere with the brain’s dopamine system, which plays a crucial role in RLS. Dopamine imbalances are thought to be a primary factor in the development and exacerbation of RLS symptoms.

Other Medications That May Trigger RLS

Benadryl is not the only medication that can potentially worsen RLS symptoms. Several other types of drugs have been associated with triggering or intensifying RLS:

  • Antidepressants
  • Antipsychotics
  • Anticonvulsants
  • Some antihistamines
  • Certain anti-nausea medications

It’s important to note that the discontinuation of certain medications, such as aripiprazole (Abilify) or tramadol, has also been reported to initiate RLS symptoms in some cases.

Managing RLS Without Medication

For those looking to manage their RLS symptoms without relying on prescription medications, several non-pharmacological approaches have shown promise:

  1. Regular exercise
  2. Maintaining a consistent sleep schedule
  3. Avoiding caffeine and alcohol, especially in the evening
  4. Practicing relaxation techniques such as yoga or meditation
  5. Using heat or cold therapy on the affected limbs

The Soap Remedy: Fact or Fiction?

An unconventional remedy that has gained popularity among RLS sufferers is placing a bar of soap under the bottom sheet of the bed. While this may sound unusual, some individuals report significant relief from their symptoms using this method. The scientific basis for this remedy is unclear, and its effectiveness may be due to a placebo effect. However, given its harmless nature, it may be worth trying for those seeking alternative relief methods.

The Importance of Consulting Healthcare Professionals

RLS can be a complex condition to manage, and what works for one person may not work for another. It’s crucial for individuals experiencing RLS symptoms to consult with healthcare professionals, particularly neurologists or sleep specialists, to develop an appropriate treatment plan.

Healthcare providers can help identify potential triggers, including medications, and suggest suitable alternatives or adjustments to current treatments. They can also rule out underlying conditions that may be contributing to RLS symptoms, such as iron deficiency or peripheral neuropathy.

Navigating Allergy Season with RLS

For RLS sufferers, allergy season can be particularly challenging. The desire for relief from allergy symptoms may lead some to reach for over-the-counter antihistamines like Benadryl, potentially exacerbating their RLS symptoms. How can individuals with both allergies and RLS manage their symptoms effectively?

Alternative Allergy Treatments for RLS Sufferers

Several options are available for managing allergy symptoms without risking RLS flare-ups:

  • Non-sedating antihistamines: These medications are less likely to worsen RLS symptoms compared to sedating antihistamines like Benadryl.
  • Nasal corticosteroid sprays: These can effectively manage nasal allergy symptoms without systemic effects.
  • Saline nasal rinses: A natural way to clear nasal passages and reduce allergy symptoms.
  • Allergen avoidance: Identifying and minimizing exposure to specific allergens can reduce the need for medication.

The Future of RLS Research and Treatment

As our understanding of RLS continues to evolve, researchers are exploring new avenues for treatment and management of the condition. Current areas of focus include:

  • Genetic factors contributing to RLS susceptibility
  • The role of iron metabolism in RLS development
  • Novel pharmacological approaches targeting dopamine and other neurotransmitter systems
  • Non-invasive brain stimulation techniques

These ongoing research efforts hold promise for improved diagnostic tools and more effective, personalized treatments for RLS in the future.

Living with RLS: Strategies for Daily Management

While navigating life with RLS can be challenging, many individuals find success in managing their symptoms through a combination of medical guidance and lifestyle adjustments. Some strategies that RLS sufferers have found helpful include:

  • Keeping a symptom diary to identify triggers and patterns
  • Incorporating regular leg stretches and massage into daily routines
  • Using compression socks or weighted blankets to provide comfort
  • Engaging in mentally stimulating activities during periods of rest to distract from symptoms
  • Creating a sleep-friendly environment with comfortable bedding and optimal room temperature

By implementing these strategies and working closely with healthcare providers, many individuals with RLS find ways to significantly improve their quality of life and manage their symptoms effectively.

The Role of Diet in RLS Management

While diet alone may not cure RLS, certain nutritional strategies can potentially help alleviate symptoms or reduce their frequency. Some dietary considerations for RLS sufferers include:

Iron-Rich Foods

Iron deficiency has been linked to RLS in some cases. Incorporating iron-rich foods into the diet may help improve symptoms, especially for those with confirmed low iron levels. Good sources of dietary iron include:

  • Lean red meat
  • Poultry
  • Fish
  • Beans and lentils
  • Dark leafy greens like spinach
  • Fortified cereals

It’s important to note that iron supplementation should only be undertaken under medical supervision, as excess iron can be harmful.

Magnesium-Rich Foods

Some studies suggest that magnesium deficiency may play a role in RLS. Including magnesium-rich foods in the diet could potentially help manage symptoms. Good sources of magnesium include:

  • Nuts and seeds
  • Whole grains
  • Avocados
  • Bananas
  • Dark chocolate

Avoiding Trigger Foods

While individual triggers can vary, some people with RLS find that certain foods or substances exacerbate their symptoms. Common culprits include:

  • Caffeine
  • Alcohol
  • Sugar
  • Processed foods high in additives

Keeping a food diary can help identify personal dietary triggers and inform more effective symptom management strategies.

The Impact of RLS on Mental Health

The chronic nature of RLS and its potential to significantly disrupt sleep can have profound effects on an individual’s mental health. Understanding and addressing these psychological aspects is crucial for comprehensive RLS management.

Sleep Deprivation and Mood

Persistent sleep disturbances caused by RLS can lead to chronic sleep deprivation, which is closely linked to mood disorders such as depression and anxiety. The fatigue and irritability resulting from poor sleep can further exacerbate these mental health challenges.

Anxiety and Stress

The anticipation of nightly symptoms can create a cycle of anxiety and stress, which may in turn worsen RLS symptoms. This feedback loop can be particularly challenging for sufferers to break without appropriate support and interventions.

Coping Strategies

Addressing the mental health aspects of RLS is essential for overall well-being. Some strategies that may help include:

  • Cognitive-behavioral therapy (CBT) to address anxiety and stress related to RLS
  • Mindfulness and relaxation techniques to manage stress and improve sleep quality
  • Support groups or counseling to connect with others experiencing similar challenges
  • Regular exercise, which can improve both physical symptoms and mental health

By addressing both the physical and psychological aspects of RLS, individuals can develop a more comprehensive approach to managing their condition and improving their overall quality of life.

Emerging Technologies in RLS Treatment

As research into RLS continues, new technologies and treatment approaches are being explored to provide relief for sufferers. While some of these methods are still in experimental stages, they offer hope for improved management options in the future.

Transcutaneous Electrical Nerve Stimulation (TENS)

TENS devices deliver low-voltage electrical currents to specific areas of the body, potentially providing relief from RLS symptoms. Some studies have shown promising results in reducing the severity and frequency of RLS episodes using this non-invasive approach.

Vibration Therapy

Targeted vibration therapy applied to the legs has shown potential in alleviating RLS symptoms for some individuals. This approach aims to provide a competing sensation that may help override the uncomfortable feelings associated with RLS.

Smart Wearables

Advances in wearable technology are opening up new possibilities for RLS management. Devices that can detect early signs of RLS episodes and provide immediate countermeasures, such as gentle vibration or compression, are being developed and tested.

Virtual Reality (VR) Distraction Therapy

VR technology is being explored as a potential tool for managing RLS symptoms, particularly during periods of rest or before sleep. By providing immersive, calming experiences, VR may help distract from RLS sensations and promote relaxation.

While these technologies show promise, it’s important to approach new treatments with caution and under the guidance of healthcare professionals. As research progresses, some of these emerging therapies may become valuable additions to the RLS management toolkit.

RLS in Special Populations

While RLS can affect anyone, certain populations may face unique challenges or considerations when it comes to managing the condition. Understanding these special cases can help in providing more targeted and effective care.

RLS in Pregnancy

Pregnancy is a known risk factor for developing or exacerbating RLS, with symptoms often peaking in the third trimester. Managing RLS during pregnancy requires careful consideration of treatment options that are safe for both mother and baby. Non-pharmacological approaches are often preferred, including:

  • Gentle exercise and stretching
  • Massage therapy
  • Ensuring adequate iron levels through diet or supplementation under medical supervision

Pediatric RLS

While less common, RLS can affect children and adolescents. Diagnosing and managing RLS in younger populations presents unique challenges, as symptoms may be described differently or mistaken for growing pains or attention deficit disorders. Treatment approaches for pediatric RLS often focus on:

  • Addressing any underlying iron deficiency
  • Establishing good sleep hygiene habits
  • Behavioral interventions to manage symptoms

RLS in Older Adults

As people age, the prevalence of RLS tends to increase. Managing RLS in older adults may require special considerations due to potential comorbidities and interactions with medications for other conditions. Strategies may include:

  • Careful medication review to identify and address potential drug interactions
  • Addressing age-related factors that may contribute to RLS, such as reduced mobility or circulatory issues
  • Implementing gentle exercise programs suitable for older adults

By recognizing the unique needs of different populations affected by RLS, healthcare providers can offer more tailored and effective management strategies, improving outcomes and quality of life for all those living with this challenging condition.

Will Benadryl Trigger Restless Legs Syndrome?

Close up Bare Feet of a Young Woman Lying Down on a Blue Bed Captured in High Angle View.

People who experience restless legs syndrome (RLS) will go to great lengths to avoid it if they can. They describe RLS as a creepy-crawly feeling that is relieved only by moving the legs. It can be quite unbearable. This uncomfortable condition can make it difficult to relax. When RLS or the related periodic limb movement disorder (PLMD) occurs overnight, sufferers and their bed partners have trouble getting a decent night’s sleep. Doctors can prescribe medications to treat RLS, but frequently they fail to warn patients about other drugs that could trigger restless legs syndrome. One reader made an independent discovery of such a drug.

What Drugs Might Trigger Restless Legs Syndrome?

Q. I never suffered before from restless legs syndrome, although it makes my daughter miserable. Last year, though, I had two episodes of RLS about a month apart. It took me a while to connect the dots, but eventually I recalled I had taken Benadryl both times right before bed to relieve hay fever symptoms. I haven’t touched the stuff since.

Does Benadryl Trigger Restless Legs Syndrome?

This is not the first time we have received such a question:

Q. The antihistamine diphenhydramine aggravates my restless legs syndrome (RLS). I have learned to avoid it and ‘PM’ pain relievers that include it.

Don’t assume your physician knows this. Several doctors I spoke with knew nothing about it. As far as I’m concerned, I’m allergic to these drugs, and that is what I tell the nurses when they ask.

A. There is little research about this link. Nevertheless, the National Institute of Neurological Disorders and Stroke advises that diphenhydramine (the antihistamine in Benadryl and “PM” pain relievers) may aggravate RLS symptoms. This is especially alarming because so many people take this over-the-counter medicine at bedtime to help them sleep. It may disrupt sleep instead for those who are susceptible to RLS.

Many other medications can also trigger these uncomfortable sensations. Antidepressants, antipsychotics and anticonvulsants can intensify this condition. Readers report that stopping some medicines, like aripiprazole (Abilify) or tramadol can also initiate symptoms.

Soap for Restless Legs Syndrome:

For those whose RLS does not appear to be set off by a medication they can avoid, we suggest soap under the bottom sheet. It sounds crazy, but some people who have tried this remedy to ward off nocturnal leg cramps have found that it also eases restless legs syndrome.

Barbara reported:

“I had suffered with RLS for years on and off. I’d go a few weeks or months without symptoms but it always came back and lasted days or weeks. When it returned, it was like torture. I definitely knew I wanted no part of a prescription drug for it, so I tried creams, herbal supplements etc. Nothing worked. A friend told me about the bar of soap under the sheet and I tried it. It has been several months and NO SYMPTOMS at all. I didn’t even unwrap it!!!”

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Common allergy medication worsens restless leg symptoms — ScienceDaily

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Date:
April 4, 2016
Source:
Houston Methodist
Summary:
Allergy season can be the worst time of year for people suffering with restless legs syndrome because popular over the counter medications can make symptoms much worse, say experts.
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FULL STORY

Allergy season can be the worst time of year for people suffering with restless legs syndrome because popular over the counter medications can make symptoms much worse.

“Patients with restless legs syndrome already have difficulty sleeping as their symptoms tend to worsen at night or with rest, but sedating antihistamines, such as Benadryl, can intensify the symptoms,” said William Ondo, M.D., a Houston Methodist neurologist.

Restless legs syndrome is considered a neurological and sleep disorder as patients feel uncomfortable sensations and strong urges to move their legs, which can sometimes be painful and often disrupts sleep. The American Sleep Association estimates that nearly 12 million people in the US have restless legs syndrome.

Many people take sedating and non-sedating antihistamines to help treat the symptoms of seasonal allergies, such as sneezing and a runny nose.

“We don’t yet understand why sedating antihistamines worsen restless legs syndrome, but we do know that non-sedating antihistamines do not affect the symptoms as much because they do not enter the brain as easily,” Ondo said. “It’s very frustrating for my patients when a sleeping pill like a sedating antihistamine doesn’t help them sleep, so I advise them to seek other allergy relief options, such as nasal sprays and decongestants. “

Ondo adds that some people who think they are allergic to Benadryl or other sedating antihistamines because it makes them feel hyper may have undiagnosed restless legs syndrome and recommends they consult with a neurologist.

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Restless legs syndrome – causes, symptoms, signs, diagnosis, treatment

Causes

Classification

Symptoms

Complications

Diagnosis

Treatment

Restless legs syndrome is a pathology that refers to neurological disorders. This disease is characterized by discomfort in the lower extremities that occurs at night and leads to lack of sleep. The patient during rest or sleep experiences burning, tingling, goosebumps. This forces the patient to move the legs. Activity helps to reduce discomfort for a while.

To confirm the diagnosis, a specialist examination, polysomnography, ENMG and other examinations are required. Physiotherapy, rituals of falling asleep, as well as taking medications help to get rid of an unpleasant ailment.

Causes

The disease is rare among children, and in adults reaches 5-10%. Restless legs syndrome is especially common in older people. Statistics show that the disease is more common among the female half of the population. Chronic sleep problems are associated with the syndrome.

In most cases, the disease is primary. In this case, it manifests itself in the patient early. In 30-90% of all cases, the pathology is hereditary. External factors also provoke the development of the syndrome.

If the disease is secondary, it occurs in a patient aged 45 years. The development of the disease is preceded by metabolic disorders, damage to the vessels and nerves of the legs.

Causes of secondary restless leg syndrome:

  • pregnancy;
  • iron deficiency;
  • kidney failure.

Other factors that cause pathology are:

  • insufficient amount of magnesium, folic acid, cyanocobalamin, thiamine in the body;
  • amyloidosis;
  • diabetes;
  • porphyria;
  • alcoholism;
  • chronic polyneuropathy;
  • spinal cord diseases;
  • vascular lesions.

The nature of the origin of the disease in humans is not fully understood. There are suggestions that the pathology is based on dopaminergic dysfunction. This opinion is supported by the success of the use of dopaminergic agents as a therapy for the disease.

Classification

It is customary to distinguish three degrees of severity of the disease:

  • mild, in which disturbing symptoms occur periodically, do not disturb the patient’s sleep and do not bring significant discomfort;
  • moderate, when symptoms of the disease appear less than 2 times a week. At the same time, sleep and quality of life suffer;
  • severe, in which sleep disturbance occurs due to unpleasant signs of the disease, disturbing the patient more than 2 times a week.

By duration, they distinguish:

  • acute syndrome, which worries no more than 14 days;
  • subacute pathology, disturbing no more than 3 months;
  • a chronic disorder that lasts more than 3 months.

Primary restless legs syndrome develops in adults aged 30-40 years, does not depend on other disorders and diseases of the patient.

ICD classifies restless legs syndrome, Willis-Ekbom disease (G25.8), as a disorder of the extrapyramidal nervous system.

Symptoms

Restless legs syndrome has the following symptoms:

  • burning;
  • tingling;
  • numbness;
  • bursting, squeezing;
  • heaviness;
  • aching pains.

The patient complains of discomfort in the area of ​​the legs, sometimes the pain occurs in the thighs, radiating to the trunk. Signs of restless legs syndrome are usually symmetrical, in rare cases there may be asymmetric unilateral manifestations.

In most patients, all symptoms appear when they are lying down – resting or sleeping. Restless legs syndrome occurs in the evening or at night. Unpleasant signs of the disease decrease if a person begins to move, therefore, during the onset of the syndrome, the patient tosses and turns in bed, performs various motor movements.

Observations show that signs of pathology are related to the time of day. The symptoms are most acute in the period from midnight to 2-4 o’clock in the morning. If the patient has a severe form of the disease, then unpleasant symptoms can haunt him around the clock. The disease disrupts sleep, so many patients suffer from insomnia, fall asleep hard, experience frequent drowsiness, fatigue.

Restless legs syndrome in children is manifested by irritability, tearfulness, excitability, morning lethargy.

Complications

The most unpleasant consequence of the syndrome for the patient is insomnia. And this disease provokes anxiety, stress, mental changes. The patient is irritable and restless, as he often wakes up in the middle of the night, falls asleep hard. Usually, people suffering from this neurological disease quickly get tired and have low working capacity. The quality of life suffers from such violations and health problems arise. Against the background of the disease, women often develop a depressive disorder.

Diagnostics

If a person has unpleasant symptoms, manifested by burning, bursting, squeezing in the lower extremities, and this affects the quality of sleep, you should seek help from a specialist. A neurologist deals with this problem.

Initial examination does not reveal disease. The doctor is based on the patient’s complaints, the duration of unpleasant manifestations.

Restless legs syndrome diagnosis consists of:

  • polysomnography;
  • electroneuromyography;
  • tests to determine the level of iron, magnesium, folic acid, B vitamins;
  • determining the functioning of the kidneys;
  • Ultrasound of the lower extremities.

Thanks to polysomnography, specialists are able to record involuntary movements of the patient. This study helps to evaluate the treatment.

Treatment

If the doctor has identified the disease in a person during the examinations, it is important to start therapy. Many patients are concerned about the question: how to deal with restless leg syndrome? It is important to find the causes of the syndrome and work with them, and not with the symptoms of the pathology.

When iron levels are low, it is important to start taking products containing the substance. It is necessary to fill all the identified deficiencies in the body.

The use of drugs such as antipsychotics, antidepressants, calcium antagonists very often provokes the disease. Reducing the dosage or stopping these medications can help get rid of the pathology.

Other non-pharmacological treatments for restless leg syndrome are:

  • normalization of the regimen;
  • moderate physical activity;
  • walks before going to bed in the fresh air;
  • exclusion of caffeine;
  • sleep ritual;
  • quitting smoking and alcohol;
  • physiotherapy procedures.

When the patient has a severe form of the disease, drug therapy is required. In the case of mild restless legs syndrome, plant-based sedatives are indicated. If we are talking about serious symptoms of pathology, doctors prescribe drugs from the groups of anticonvulsants, benzodiazepines, dopaminergic drugs to patients. Sometimes efficiency can be achieved by combining several groups of medicines.

In pregnant women with restless legs syndrome, the choice of drugs is always cautious, usually non-drug forms of therapy or sedatives are dispensed with. With a lack of iron or folic acid, appropriate drugs are prescribed.

Among the clinical recommendations for restless legs syndrome are:

  • timely treatment of kidneys, vascular disorders, spinal cord injuries;
  • replenishment of deficiencies of substances in the body;
  • normalization of the daily routine;
  • rejection of bad habits;
  • walks before going to bed;
  • moderate exercise during the day;
  • reducing or avoiding caffeine.

The author of the article:

Markelov Gleb Vladimirovich

neurologist, online consultations

work experience 4 years

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