What is the best time to take Wellbutrin XL. How do strengths and forms of Wellbutrin differ. When should Wellbutrin be used for depression and seasonal affective disorder. What are the recommended dosages for different conditions.

Understanding Wellbutrin: Forms and Strengths

Wellbutrin, also known by its generic name bupropion hydrochloride, is a widely prescribed antidepressant medication. It comes in two primary forms: sustained-release (SR) and extended-release (XL) oral tablets. Both versions are designed to release the medication slowly over time, providing a steady therapeutic effect throughout the day.

Wellbutrin SR (Sustained-Release)

Wellbutrin SR is available in three strengths:

• 100 milligrams (mg)
• 150 mg
• 200 mg

Wellbutrin XL (Extended-Release)

Wellbutrin XL comes in two strengths:

• 150 mg
• 300 mg

The choice between SR and XL formulations, as well as the specific strength, depends on the patient’s condition, severity of symptoms, and individual response to the medication.

Optimal Timing for Taking Wellbutrin XL

When is the best time to take Wellbutrin XL? The extended-release formulation of Wellbutrin XL is typically taken once daily, preferably in the morning. This timing aligns with the body’s natural circadian rhythm and helps maintain consistent blood levels of the medication throughout the day.

Taking Wellbutrin XL in the morning offers several benefits:

1. It may help reduce the risk of sleep disturbances, a potential side effect of the medication.
2. Morning dosing can help improve energy levels and focus during the day.
3. It establishes a consistent routine, making it easier to remember to take the medication regularly.

Are there exceptions to the morning dosing recommendation? In some cases, healthcare providers might suggest taking Wellbutrin XL at a different time of day based on individual patient needs and tolerability. However, it’s crucial to follow your doctor’s specific instructions regarding the timing of your medication.

Dosage Guidelines for Depression Treatment

How should Wellbutrin be dosed for depression? The dosage of Wellbutrin for depression typically follows a gradual titration schedule to minimize side effects and optimize therapeutic benefits.

Wellbutrin XL Dosage for Depression

For patients prescribed Wellbutrin XL to treat major depressive disorder:

• Starting dose: 150 mg once daily, taken in the morning
• After at least 4 days: Dosage may be increased to 300 mg once daily
• Maximum recommended dose: 300 mg once daily

Wellbutrin SR Dosage for Depression

If Wellbutrin SR is prescribed for depression:

• Starting dose: 150 mg once daily, taken in the morning
• After 3 days: May increase to 150 mg twice daily
• If needed: Dosage can be further increased to 200 mg twice daily
• Maximum recommended dose: 200 mg twice daily

Why does the dosage start low and increase gradually? This approach allows the body to adjust to the medication, reducing the likelihood of side effects while establishing an effective therapeutic level.

Wellbutrin XL for Seasonal Affective Disorder (SAD)

Can Wellbutrin XL be used to prevent seasonal affective disorder? Yes, Wellbutrin XL is approved for the prevention of seasonal affective disorder (SAD), a type of depression that occurs with seasonal changes, typically during fall and winter months.

The recommended dosing schedule for SAD prevention with Wellbutrin XL is:

• Starting dose: 150 mg once daily
• After 7 days: May increase to 300 mg once daily

When should treatment for SAD begin and end? Treatment typically starts in the autumn, before the onset of symptoms, and continues through early spring. The dosage is then gradually tapered off as directed by a healthcare provider.

Is Wellbutrin SR used for SAD? It’s important to note that Wellbutrin SR is not approved for the treatment or prevention of seasonal affective disorder.

Long-Term Use of Wellbutrin

How long should Wellbutrin be taken for depression? For major depressive disorder, both Wellbutrin XL and SR are intended for long-term use. The duration of treatment is determined by the healthcare provider based on the individual’s response and ongoing needs.

In contrast, Wellbutrin XL for SAD is typically a short-term, seasonal treatment. Patients usually take the medication from autumn to early spring, with a break during the summer months. This cyclical approach aligns with the seasonal nature of SAD symptoms.

Why is it important not to stop Wellbutrin abruptly? Discontinuing Wellbutrin suddenly can lead to withdrawal symptoms and a potential recurrence of depression. Always consult with your healthcare provider before making any changes to your medication regimen.

Special Considerations and Potential Side Effects

What factors might affect Wellbutrin dosage? Several factors can influence the appropriate dosage of Wellbutrin, including:

• Age
• Liver function
• Kidney function
• Other medications being taken
• Presence of other medical conditions

Are there common side effects associated with Wellbutrin? Like all medications, Wellbutrin can cause side effects. Some of the more common ones include:

• Dry mouth
• Nausea
• Insomnia
• Agitation
• Headache
• Constipation

How can side effects be managed? Many side effects are temporary and subside as the body adjusts to the medication. However, if side effects persist or worsen, it’s important to consult with your healthcare provider. They may adjust the dosage or recommend strategies to manage side effects effectively.

Wellbutrin and Weight Management

Does Wellbutrin affect weight? While Wellbutrin is not approved for weight loss, some patients may experience changes in weight while taking the medication. Unlike some other antidepressants that can lead to weight gain, Wellbutrin is generally considered weight-neutral or may even be associated with modest weight loss in some individuals.

Why might Wellbutrin influence weight? The exact mechanism is not fully understood, but it may be related to the medication’s effects on dopamine and norepinephrine, neurotransmitters that play a role in appetite regulation and metabolism.

Is Wellbutrin prescribed for weight loss? No, Wellbutrin is not approved or recommended as a weight loss medication. Any changes in weight should be discussed with a healthcare provider to ensure they are not indicative of other health issues.

Interactions and Precautions

What substances should be avoided while taking Wellbutrin? Certain medications and substances can interact with Wellbutrin, potentially affecting its efficacy or increasing the risk of side effects. These include:

• Monoamine oxidase inhibitors (MAOIs)
• Alcohol
• Certain antipsychotics
• Some antidepressants
• Seizure medications

Are there specific precautions for Wellbutrin use? Wellbutrin carries a boxed warning for an increased risk of suicidal thoughts and behaviors, particularly in children, adolescents, and young adults. Close monitoring is essential, especially during the initial treatment period and with any dose changes.

Who should exercise caution with Wellbutrin? Certain groups may need special consideration or closer monitoring when using Wellbutrin:

• Individuals with a history of seizures
• Those with eating disorders
• Patients with bipolar disorder
• People with liver or kidney impairment
• Pregnant or breastfeeding women

How can patients ensure safe use of Wellbutrin? It’s crucial to provide a complete medical history to your healthcare provider, including all medications, supplements, and substances used. Regular follow-ups and open communication about any changes in symptoms or side effects are essential for safe and effective treatment.

Wellbutrin, in its various forms and strengths, offers a valuable treatment option for individuals struggling with depression and seasonal affective disorder. By understanding the optimal dosing schedules, timing considerations, and potential effects, patients and healthcare providers can work together to maximize the benefits of this medication while minimizing risks. As with any prescription medication, personalized care and ongoing monitoring are key to achieving the best possible outcomes.

Strengths, forms, when to use, and more

Wellbutrin (bupropion hydrochloride) is a brand-name drug that’s prescribed for certain types of depression. This medication comes in sustained-release or extended-release oral tablets and is typically taken once or twice per day. The dosage can vary, depending on the condition the drug is used to treat.

Wellbutrin belongs to a drug class called antidepressants. It’s available in a generic version.

This medication comes in two different forms: Wellbutrin sustained-release (SR) and Wellbutrin extended-release (XL) tablets. Both Wellbutrin SR and XL release medication slowly over time in your body. Wellbutrin isn’t available as an immediate-release form.

Keep reading for specific information about the dosage of Wellbutrin, including its strengths and how to take medication. For a comprehensive look at Wellbutrin, see this article.

Note: This article describes typical dosages for Wellbutrin provided by the drug’s manufacturer. When taking Wellbutrin, always follow the dosage prescribed by your doctor.

Your doctor will recommend the best dosage of Wellbutrin for you, based on your condition and how severe it is.

Wellbutrin forms

Wellbutrin comes in two forms: sustained-release (SR) oral tablets and extended-release (XL) oral tablets.

Both of these medications release slowly into your body over time.

Wellbutrin strengths

Wellbutrin SR is available in three strengths: 100 milligrams (mg), 150 mg, and 200 mg.

Wellbutrin XL is available in two strengths: 150 mg and 300 mg.

Typical dosages

Typically, your doctor will start you on a low dosage. Then, they’ll adjust it over time to reach the amount that’s right for you. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect.

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Dosage for depression

Both Wellbutrin XL and Wellbutrin SR are approved to help treat major depressive disorder. This condition is commonly called depression.

If your doctor prescribes Wellbutrin XL for your depression, your starting dose will likely be 150 mg. Typically, you’ll take this once per day when you first wake up. After at least 4 days, your doctor may recommend increasing your dosage to 300 mg per day. This is the typical recommended dosage of Wellbutrin XL for people with depression.

If your doctor prescribes Wellbutrin SR for your depression, your starting dose will also likely be 150 mg. Typically, you’ll take this once per day when you first wake up. This is the lowest dose of Wellbutrin SR that’s recommended. Then, after 3 days, your doctor may increase your dose to 150 mg twice daily. If this dose isn’t working for you, your doctor may recommend another dose increase, up to 200 mg twice daily to treat your depression. This is the maximum dose of Wellbutrin SR that’s recommended.

Dosage for seasonal affective disorder

Wellbutrin XL is also approved to help prevent seasonal affective disorder (SAD). In this case, the recommended starting dose of Wellbutrin XL is 150 mg. You’ll usually take this once per day. After 7 days, your doctor may recommend increasing your daily dose to 300 mg.

For this use, your doctor may recommend starting Wellbutrin XL treatment before your symptoms begin. Typically, this happens in the autumn. Then, they may slowly decrease your dose in the early spring. Do not stop taking Wellbutrin XL without first talking with your doctor. It’s important that your doctor slowly decreases your dose of this medication over time. Doing so can help you avoid certain side effects of the drug.

It’s important to note that Wellbutrin SR isn’t approved to treat SAD.

Long-term treatment

For depression, Wellbutrin XL and Wellbutrin SR are meant to be taken as long-term treatments. If you and your doctor determine that Wellbutrin XL and Wellbutrin SR are safe and effective for you, you’ll likely take them long term.

For SAD, Wellbutrin XL is meant to be taken as a short-term treatment during certain times of the year. You’ll likely take the drug from autumn to early spring and stop taking it during the summer. Your doctor may prescribe the drug again in the autumn. This is because symptoms of SAD generally occur during the winter and get better in spring.

If you have questions about how long you’ll take Wellbutrin, talk with your doctor.

Here are some frequently asked questions about Wellbutrin.

Can Wellbutrin be used for weight loss or anxiety? If so, what is the dosage?

No, neither form of Wellbutrin is approved for weight loss or anxiety at this time. Wellbutrin sustained-release (SR) tablets are only approved to treat depression. Wellbutrin extended-release (XL) tablets are only approved to treat depression and help prevent seasonal affective disorder (SAD).

For this reason, there aren’t any recommended Wellbutrin dosages to treat weight loss or anxiety.

If you have questions about managing these conditions, talk with your doctor. They can recommend treatment options for weight management or anxiety.

Will my doctor increase my Wellbutrin dose from 150 mg to 300 mg?

It’s possible. Wellbutrin XL tablets are available in 150-milligram (mg) and 300-mg strengths. If you currently take 150 mg of Wellbutrin XL, your doctor may increase your dose to 300 mg. This may depend on many factors, including the severity of your condition and whether you have kidney or liver problems.

Be sure to take Wellbutrin exactly how your doctor prescribes. They will recommend the best dosage for you.

Is there a 600-mg daily dosage of Wellbutrin?

No, there isn’t a 600-mg daily dosage of Wellbutrin. The maximum dosage of Wellbutrin XL is 450 mg per day. The maximum dosage of Wellbutrin SR is 400 mg per day.

Wellbutrin contains the active drug bupropion. In clinical trials of bupropion, taking 600 mg per day increased the risk of certain side effects, including seizure. For more information on this and other side effects of Wellbutrin, see this article.

If you have questions about your dosage of Wellbutrin, talk with your doctor. They will recommend the best dosage of Wellbutrin to help treat your depression or help prevent SAD.

The Wellbutrin dosage your doctor prescribes will depend on several factors. These include:

• the type and severity of the condition you’re using Wellbutrin to treat
• the form of Wellbutrin you take

Other medical conditions, such as kidney or liver problems, can also affect your Wellbutrin dosage.

Dosage adjustments

In some cases, your doctor may recommend adjusting your dosage of Wellbutrin. This may occur if you have kidney or liver problems. In this case, your doctor may recommend that you take a lower dose of the drug.

Be sure to tell your doctor about any kidney or liver problems that you have before starting treatment with Wellbutrin. They can recommend the dosage that’s best dosage for you.

Wellbutrin sustained release (SR) and extended release (XL) come as oral tablets that are taken by mouth. You should swallow Wellbutrin tablets whole. Be sure not to chew, crush, or break Wellbutrin tablets.

It may be helpful to take Wellbutrin around the same time of day. This helps maintain a steady level of the drug in your body so Wellbutrin can work effectively.

If you’re taking Wellbutrin SR, you’ll usually take your dose twice per day. Your doctor or pharmacist will typically recommend taking your doses of Wellbutrin SR at least 8 hours apart. You can take Wellbutrin SR with or without food.

You should take your dose of Wellbutrin XL when you first wake up. You can take this medication with or without food.

If you need to stop taking either form of Wellbutrin for any reason, talk with your doctor first. They’ll likely recommend slowly decreasing your dose of Wellbutrin over time. Stopping Wellbutrin suddenly may increase your risk of serious side effects, such as seizure. For more information on Wellbutrin’s side effects, including seizure, refer to this article.

If you have trouble swallowing tablets, see this article for tips on how to take this form of medication. You can also talk with your doctor or pharmacist.

ACCESSIBLE DRUG LABELS AND CONTAINERS

If you’re having trouble reading your prescription label, talk with your doctor or pharmacist. Some pharmacies offer labels with large print, braille, or a code you scan with a smartphone to convert text to speech. If your local pharmacy doesn’t have these options, your doctor or pharmacist might be able to recommend a pharmacy that does.

If you’re having trouble opening medication bottles, ask your pharmacist about putting Wellbutrin in an easy-open container. They also may recommend tools that can make it easier to open bottles.

If you miss your dose of Wellbutrin, skip your missed dose and take your next dose as scheduled. You should never take an extra dose of Wellbutrin to make up for a missed dose. Taking too much of this medication may increase your risk of certain side effects, such as seizure. For more information on seizure and other side effects of Wellbutrin, see this article.

If you’re ever unsure whether to skip your missed dose, ask your doctor or pharmacist.

To help make sure that you don’t miss a dose, try using a medication reminder. This can include setting an alarm or putting a note where you’ll see it, such as on your bathroom mirror or bedside table. You could also download a reminder app on your phone.

If you take more Wellbutrin than your doctor prescribes, you may develop serious side effects.

It’s important that you do not take more Wellbutrin than your doctor advises.

Symptoms of an overdose

Overdose symptoms of Wellbutrin can include:

• hallucination
• seizure
• loss of consciousness
• changes in mental state
• heart rhythm problems

If you take more than the recommended amount of Wellbutrin

Call your doctor right away if you believe you’ve taken too much Wellbutrin. Another option is to call America’s Poison Centers at 800-222-1222 or use its online tool. If you have severe symptoms, immediately call 911 or your local emergency number, or go to the nearest emergency room.

Neither Wellbutrin sustained release (SR) or extended release (XL) are known to cause withdrawal symptoms or dependence. With dependence, your body needs the drug to feel like it usually does. A dependence can develop even if you take a drug exactly as prescribed. Withdrawal symptoms can occur when you suddenly stop taking a drug your body is dependent on.

Although Wellbutrin isn’t known to cause withdrawal or dependence, you should never stop taking it suddenly. Stopping Wellbutrin suddenly may increase the risk of certain side effects, including seizure. If you need to stop taking Wellbutrin, talk with your doctor first. They can recommend the best way to slowly decrease your dose of Wellbutrin to prevent side effects from occurring.

For more information on Wellbutrin’s side effects, including seizure, see this article. You can also talk with your doctor or pharmacist.

The dosages in this article are typical dosages provided by the drug’s manufacturer. If your doctor recommends Wellbutrin for your condition, they’ll prescribe the dosage that’s right for you. Always follow the dosage that your doctor prescribes.

As with any drug, never change your dosage of Wellbutrin without your doctor’s recommendation. If you have questions about the dosage of Wellbutrin that’s best for you, talk with your doctor.

Besides learning about dosage, you may want other information about Wellbutrin. These additional articles might be helpful:

• More about Wellbutrin. For information about other aspects of Wellbutrin, refer to this article.
• Side effects. To learn about side effects of Wellbutrin, see this article. You can also look at the prescribing information for Wellbutrin SR and Wellbutrin XL.
• Interactions. For details about what Wellbutrin interacts with, see this article.
• Details about depression. For details about depression, see our depression hub.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

Can You Take Wellbutrin At Night Instead of in The Morning?

Pills are one of the most convenient inconveniences of the modern day. A scientifically engineered capsule to improve your body — all you have to do is take it as directed. That’s where the problems come in though. With food or without? Day or night? Skip a dose or take an extra? And when it comes to Wellbutrin, one of the questions we see most is whether you can take Wellbutrin at night instead of morning.

Wellbutrin is an effective way to treat mood disorders, including depression, anxiety, panic attacks and more, but it does have some limitations. The internet is rife with all manner of complaints and anecdotal observations of side effects from medications, but Wellbutrin seems to get a lot of attention for the dangers of taking it at the wrong time of day. 

Maybe you missed a dose or two of your current prescription, or maybe you’re researching when to take your new pill for the best results. Maybe you’re just a night owl wondering what fresh hell you’ll unleash on yourself if you take antidepressants at a different time than directed. We don’t know you — we’re not here to judge.  

All we’re here to do is explain this whole Wellbutrin at night problem in simple terms. In fact, let’s jump straight into the question — does it matter what time you take Wellbutrin?

SPECIAL OFFER ⏰

Save when you sign up for 3-months supply.

FREE ASSESSMENT

Does It Matter What Time of Day I Take Wellbutrin?

Wellbutrin is the brand-name version of the antidepressant bupropion, which wasapproved by the FDA in 1985.

Bupropion isn’t what you’d usually think of when you think of an antidepressant — while many antidepressants use a mechanism of action that affects your brain’s serotonin levels, bupropion actually targets dopamine levels (a pleasure neurotransmitter) and norepinephrine (a stress neurotransmitter). 

These neurotransmitters serve slightly different purposes than serotonin, but all are crucial to regulate depressed moods.

So, a norepinephrine and dopamine reuptake inhibitor (NDRI) like bupropion can be a valuable tool for some people whose depression is resistant to treatment with selective serotonin reuptake inhibitors (SSRIs) or who can’t tolerate the common side effects of SSRIs, including sexual side effects.  

Wellbutrin is FDA-approved for treating a variety of medical conditions, not just limited to depressive disorders.

Bupropion can also help some people with smoking cessation, treat seasonal affective disorder (also known as seasonal depression), and in an off-label capacity, it can be used to treat attention deficit hyperactivity disorder (compare Wellbutrin and Adderall), sexual dysfunction as a result of antidepressants and bipolar disorder, as well as help people with obesity lose weight and help others cope with anxiety.

If you’re saying “wow that’s a lot,” then, yeah, you’re right. But for all Wellbutrin’s benefits, it also has some significant adverse effects to worry about.

Potential risks or side effects of Wellbutrin include constipation, dry mouth, nausea, tremors, headaches, agitation, dizziness, weight loss and insomnia. In severe (and rare) cases, it can lead to seizure disorders, raise your risk of suicidality or cause allergic reactions. But insomnia, as you might have guessed, is where the question of what time of day to take Wellbutrin comes in.

According to the National Library of Medicine, bupropion can cause problems with falling asleep or staying asleep, and it can potentially cause some adverse effects if taken alongside sleep aids.

What this means is that if you have trouble sleeping already, Wellbutrin might exacerbate the problem, particularly if taken right before bed. Or for some people, it can cause new sleep issues.

Can You Take Wellbutrin at Night vs in The Morning?

So you could take Wellbutrin at any time of day, really — there’s no internal mechanism of this medication in its oral tablet form (or any other delivery method, like an extended-release tablet) that causes it to fail if taken after dinner.

There’s likewise no risk of immediate death from swallowing bupropion medications after sunset, like some sort of vampire/werewolf prescription nightmare.

When Should I Take Wellbutrin?

What’s generally agreed upon, however, is that there are certain ideal circumstances for taking your daily dose, and neglecting them might cause problems.  

Wellbutrin can sometimes cause stomach pain, for instance, so experts sometimes recommend taking it with food if you have this symptom. And while not everyone experiences it, some people do indeed have trouble sleeping on this medication.

If that’s you, it’s generally agreed that you should try to take Wellbutrin in the morning or during the day, so the side effects are lessened by the time you’re hitting the hay.

Officially, that recommendation is simply that you avoid taking bupropion “close to bedtime” if you’re experiencing insomnia, but popping it right after you wake up puts your medication intake as far from bedtime as possible.

Just don’t skip too many doses of bupropion to rearrange your schedule — Wellbutrin withdrawal symptoms can be rough.

Taking Wellbutrin At Night: The Final Word

Used correctly, bupropion can be an effective way to treat depressive disorder, prevent weight gain, and help people with depressive disorder who need atypical antidepressants after struggling with the side effects — including sexual side effects — of other classes of antidepressants.

But those benefits don’t earn Wellbutrin a pass on insomnia, which means that you might have to weigh some pros and cons of taking this medication. 

If you’re struggling with insomnia from bupropion, consider switching your daily schedule to front-load this medication, rather than using it before bed. But if you’re not yet on bupropion and are considering this drug class for your treatment of depression, consider speaking to a healthcare professional about your concerns. 

Mental illness is not a one-size-fits-all kind of condition, and there are a variety of reasons to consider treatments that don’t work for other people as the option for you. Likewise, it’s important to realize that a medication other people have had success with doesn’t necessarily promise the same results for your needs. 

If you’re ready to get the mental health relief you need, consider using our resources for mental health and online therapy to connect with a healthcare provider. 

2 Sources

Hims & Hers has strict sourcing guidelines to ensure our content is accurate and current. We rely on peer-reviewed studies, academic research institutions, and medical associations. We strive to use primary sources and refrain from using tertiary references.

1. Huecker MR, Smiley A, Saadabadi A. Bupropion. [Updated 2021 Oct 17]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470212/.
2. U.S. National Library of Medicine. (n.d.). Bupropion: MedlinePlus Drug Information. MedlinePlus. https://medlineplus.gov/druginfo/meds/a695033.html.

Memorial Sloan Kettering Cancer Center

Adult Medication

Share

Provided by Lexicomp ^® , this document contains all the information you need to know about this medicine, including indications, directions for use, side effects, and when your healthcare provider should be contacted.

Trade names: USA

Aplenzin; Forfivo XL; Wellbutrin SR; Wellbutrin XL; Zyban[DSC]

Trade names: Canada

MYLAN-BuPROPion XL [DSC]; ODAN Bupropion SR; TARO-Bupropion XL; TEVA-Bupropion XL; Wellbutrin SR; Wellbutrin XL; Zyban

Warning

• Drugs like this have increased the likelihood of suicidal thoughts or actions in children and young people. This risk may be higher in people who have tried or had suicidal thoughts in the past. All people taking this drug must be closely monitored. If you develop or worsen disorders such as depression, nervousness, anxiety, grouchiness, panic attacks, and changes in mood or behavior, contact your doctor immediately. Contact your doctor immediately if you have suicidal thoughts or suicide attempts.

What is this drug used for?

• Used to treat depression.
• Used to prevent seasonal affective disorder (SAD).
• Used to stop smoking.
• This drug may also be used for other indications. Consult your doctor.

What should I tell my doctor BEFORE taking this drug?

• If you have an allergy to this drug, any of its ingredients, other drugs, foods or substances. Tell your doctor about your allergies and how they have manifested.
• If you have ever had seizures.
• If you abuse alcohol and suddenly stopped using it.
• If you are taking certain other drugs, such as anticonvulsants or tranquilizers, and you stop taking them abruptly.
• If you have ever had an eating disorder such as anorexia or bulimia.
• If you have any of the following health conditions: kidney disease or liver disease.
• If you have taken medications for depression or Parkinson’s disease in the past 14 days. These include isocarboxazid, phenelzine, tranylcypromine, selegiline, or rasagiline. An episode of very high blood pressure may occur.
• If you are taking any of the following drugs: linezolid or methylene blue.
• If you are taking another drug that contains the same medicine.

This list of drugs and conditions that may interact with this drug is not exhaustive.

Tell your doctor and pharmacist about all medicines you take (both prescription and over-the-counter, natural products and vitamins) and any health problems you have. You need to make sure that this drug is safe for your conditions and in combination with other drugs you are already taking. Do not start or stop taking any drug or change the dosage without your doctor’s advice.

What do I need to know or do while taking this drug?

For all patients taking this drug:

• Tell all your health care workers that you are taking this drug. These are doctors, nurses, pharmacists and dentists.
• Avoid driving or doing other tasks or jobs that require alertness or keen eyesight until you know how this drug affects you.
• This drug may affect the results of some lab tests. Tell all your health care workers and laboratory staff that you are taking this drug.
• Do not stop taking this drug abruptly without consulting your doctor. This can increase the risk of side effects. If necessary, taking this drug should be stopped gradually, in accordance with the recommendations of the doctor.
• High blood pressure has happened with this drug. Monitor your blood pressure as directed by your doctor.
• This drug may increase the risk of seizures. The risk may be increased in people who take higher doses of the drug, who have certain health problems, or who use certain other drugs. People who abruptly stop drinking large amounts of alcohol or abruptly stop taking certain medications (such as drugs used for anxiety, insomnia, or seizures) are also at higher risk. Talk to your doctor to find out if you have an increased risk of seizures.
• Avoid drinking alcohol while taking this drug.
• Check with your doctor before using marijuana, other forms of cannabis, or prescription or over-the-counter drugs that can slow you down.
• It may take several weeks to achieve full effect.
• This drug is not approved for use in children. Consult your doctor.
• If you are 65 years of age or older, use this drug with caution. You may experience more side effects.
• Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding. The benefits and risks for you and your child will need to be discussed.

If you smoke:

• Not all drugs are approved for use to help you quit smoking. Check with your doctor to make sure you get the right drug.
• When using bupropion for smoking cessation, the appearance of new or aggravation of existing disorders of the psyche, mood or behavior was noted. These disturbances include suicidal or homicidal thoughts, depression, violent acts, rage, anxiety and anger. These disorders have been observed in people with and without mental and mood disorders in the past. Consult your doctor.

What side effects should I report to my doctor immediately?

WARNING. In rare cases, this drug can cause serious and sometimes deadly side effects in some patients. Contact your doctor or seek medical attention right away if you have any of the following signs or symptoms that may be associated with serious side effects:

• Signs of an allergic reaction, such as rash, hives, itching, red and swollen skin with blisters or peeling, possibly accompanied by fever, wheezing or wheezing, tightness in the chest or throat, difficulty breathing, swallowing or speaking, unusual hoarseness, swelling in the mouth, face, lips, tongue or throat.
• Signs of high blood pressure, such as a very severe headache, or dizziness, or loss of consciousness, or blurred vision.
• Feelings of confusion, inability to concentrate, or changes in behavior.
• Hallucinations (a person sees or hears something that is not in reality).
• If, after starting the medication, seizures become more frequent or severe.
• Chest pain, angina pectoris, tachycardia, or abnormal heart rhythm.
• Inflammation.
• Dyspnea.
• Hearing change.
• Tinnitus.
• Frequent urination.
• Swelling of the gland.
• Violation of motor functions.
• Some patients may be at increased risk of eye problems when using this drug. Your doctor may order an eye examination to see if you are at increased risk for these eye problems. Call your doctor right away if you have eye pain, vision changes, swelling or redness around the eye.
• Possible severe skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis). This can lead to severe health problems, which can be permanent, and sometimes death. Seek immediate medical attention if you experience symptoms such as redness, swelling of the skin with blistering or peeling (with or without fever), redness or irritation of the eyes, and sores in the mouth, throat, nose, or eyes.

What are some other side effects of this drug?

Any medicine can have side effects. However, for many people, side effects are either minor or non-existent. Contact your doctor or seek medical attention if these or any other side effects bother you or do not go away:

All formulations:

• Dizziness or headache.
• Constipation, diarrhea, abdominal pain, nausea, vomiting, or decreased appetite.
• Shiver.
• Nervous tension and agitation.
• Strange or unusual dreams.
• Gas formation.
• Dry mouth.
• Sleep disorders.
• Pain in the joints or muscles.
• Irritation of the nose or throat.
• Excessive sweating.
• Unexplained fluctuations in weight.

Extended release tablets:

• The tablet shell of some brand name drugs can sometimes be seen in the stool. For drugs of these brands, this is normal and does not cause concern. If you have any questions, please consult your doctor.

This list of possible side effects is not exhaustive. If you have any questions about side effects, please contact your doctor. Talk to your doctor about side effects.

You can report side effects to the National Health Board.

You can report side effects to the FDA at 1-800-332-1088. You can also report side effects at https://www.fda.gov/medwatch.

What is the best way to take this drug?

Use this drug as directed by your doctor. Read all the information provided to you. Strictly follow all instructions.

For all uses of this drug:

• Do not take the drug more often than prescribed. This may increase your risk of developing seizures. Make sure you know at what intervals you need to use the drug.
• Take in the morning if you are taking this drug once a day.
• Take this drug with or without food.
• If you cannot sleep, do not take this drug at bedtime. Consult your doctor.
• Swallow whole. Do not chew, break or crush.
• Keep taking this drug as instructed by your doctor or other health care professional, even if you feel well.
• If you have difficulty swallowing, check with your doctor.

For smoking cessation:

• You can take this drug for 1 week before you stop smoking.
• Nicotine replacement and psychological help can be done at the same time for best results.
• If you have not been able to stop smoking after 12 weeks of taking this drug, talk with your doctor.
• When you try to quit smoking, you may experience nicotine withdrawal symptoms even if you use quit smoking drugs like this drug. There are many signs of nicotine withdrawal. People who are trying to quit smoking have occasionally experienced depression and suicidal thoughts. Consult with your physician.

What if I miss a dose of a drug?

• Skip the forgotten dose and return to your regular schedule.
• Do not take 2 doses or an additional dose at the same time.

How do I store and/or discard this drug?

• Store at room temperature, protected from light. Store in a dry place. Do not store in the bathroom.
• Keep all medicines in a safe place. Keep all medicines out of the reach of children and pets.
• Dispose of unused or expired drugs. Do not empty into a toilet or sewer unless instructed to do so. If you have any questions about disposing of medicines, ask your pharmacist. Drug disposal programs may be in place in your area.

General information about medicines

• If your health does not improve or even worsens, see your doctor.
• Do not give your medicine to anyone and do not take other people’s medicines.
• Some medicines may come with other patient information leaflets. If you have questions about this drug, talk with your doctor, nurse, pharmacist, or other health care professional.
• A separate instruction for patients is attached to the drug. Please read this information carefully. Reread it each time you refill your supply. If you have any questions about this drug, ask your doctor, pharmacist, or other health care professional.
• If you think you have overdosed, call a poison control center or get medical help right away. Be prepared to tell or show what drug you took, how much, and when it happened.

Consumer Use of Information and Limitation of Liability

This summary information includes a summary of the diagnosis, treatment, and/or drug product. It is not intended to be a comprehensive source of data and should be used as a tool to help the user understand and/or evaluate potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a particular patient. It should not be considered medical advice or a substitute for medical advice, diagnosis or treatment provided by a physician based on a medical examination and assessment of the patient’s specific and unique circumstances. Patients should consult with their physician for full information about their health, medical issues, and treatment options, including any risks or benefits regarding the use of medications. This information is not a guarantee that a treatment or drug is safe, effective, or approved for a particular patient. UpToDate, Inc. and its subsidiaries disclaim any warranties or liabilities related to this information or its use. The use of this information is subject to the Terms of Use found at https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms.

Last revision date

2021-07-28

Copyright

© UpToDate, Inc. and its affiliates and/or licensors, 2023. All rights reserved.

Date last updated

Monday, December 12, 2022

International Journal of Heart and Vascular Disease

International Journal of Heart and Vascular Disease

Published since 2013
ISSN: 2311-1623 (print)
ISSN: 2311-1631 (electronic)
Full-text versions of all issues are posted on the websites: www.elibrary.ru, www.cyberleninka.ru

EN | EN

Full version of the number in PDF (RU)
Message from the editor-in-chief PDF (RU 9) 0285 )
Review of foreign medical news

CURRENT NUMBER

EDITORIAL

Iskenderov B.G.

Familial form of sick sinus syndrome. New Perspectives on Polygenic Origins and Prospects for Gene Therapy

5-16

Full text I Abstract I For citation

ORIGINAL

S. G. Kanorsky, D. I. Panchenko ., Bystrov A. O., Moisova D. L., Gorodin V. N., Ionov A. Yu.
Echocardiographic changes in patients with COVID-19, 6 and 12 months after discharge from hospital
17-24

Full textI Abstract I For citation

900 02 Starichkova A. A., Khidirova L. D., Tsygankova O. V. ., Vasilenko A. А.

Olesin A.I., Konstantinova I.V., Tyuteleva N.N., Ivanov V.S.
Use as primary prevention of atrial fibrillation to correct potentially modifiable predictors of its development in comorbid patients with abdominal obesity. Prospective study
35-44

Full text I Abstract I For citation

Akimov A. M., Novoselov A. V., Lebedev E. V., Kayumova M. M. .
Some factors of chronic social stress associated with the development of cardiovascular diseases
45-53

Full textI Abstract I For citation

90 003

Mamadumarov M. A.

Prevalence and features of dyslipidemia in different populations, taking into account racial, ethnic, gender and age affiliation

54-62
Full textI Abstract I For citation

Leading Cardiology Journal Club

900 02

FAQ

9 0070 Dear Colleagues and authors!

During the preparation of articles for publication, you have questions, taking into account which the editors have prepared materials in the format of answers to the most frequently asked questions.

S.G. Kanorsky, MD, professor, Deputy editor -in -chief

Where is MHSSZZ ? The journal is included in the list of the Higher Attestation Commission, and is available in the public domain in the DOAJ, RSCI and Cyberleninka databases.