What are the benefits of bioflavonoids? How do they interact with other medications? What is the recommended dosage? Find answers to these and other questions about bioflavonoids.

Understanding Bioflavonoids

Bioflavonoids, also known as flavonoids, are a group of naturally occurring plant compounds that exhibit a wide range of health benefits. They are found in various fruits, vegetables, and other plant-based foods, such as the rind of citrus fruits, rose hips, and black currants. Bioflavonoids are known for their antioxidant properties and have been studied for their potential to support cardiovascular health, reduce inflammation, and enhance the effects of vitamin C.

Health Benefits of Bioflavonoids

Bioflavonoids have been the subject of extensive research, and studies have suggested several potential health benefits:

Antioxidant Properties

Bioflavonoids are potent antioxidants that can help neutralize harmful free radicals and protect cells from oxidative stress. This antioxidant activity may contribute to their ability to support overall health and well-being.

Cardiovascular Health

Bioflavonoids have been shown to help support healthy blood circulation, improve blood vessel function, and potentially lower the risk of certain cardiovascular conditions. Some studies have linked bioflavonoid intake to a reduced risk of heart disease and stroke.

Inflammation Reduction

Bioflavonoids possess anti-inflammatory properties that may help reduce inflammation throughout the body. This can be particularly beneficial for individuals with inflammatory conditions, such as osteoarthritis, rheumatoid arthritis, and certain skin disorders.

Immune System Support

Bioflavonoids may help bolster the immune system by enhancing the activity of immune cells and increasing the production of antibodies. This could potentially help the body fight off infections and maintain overall health.

Bioflavonoids and Vitamin C

Bioflavonoids are often touted for their ability to enhance the effects of vitamin C. While the exact mechanisms are not fully understood, research suggests that bioflavonoids may help vitamin C more effectively reach and be utilized by the body’s cells. This synergistic relationship between bioflavonoids and vitamin C is one of the reasons why some health experts recommend consuming them together.

Potential Side Effects and Interactions

While bioflavonoids are generally considered safe when taken in appropriate amounts, there are a few potential side effects and interactions to be aware of:

Side Effects

Common side effects of bioflavonoid supplements may include blurred vision, fast or slow heart rate, headache, dizziness, and skin irritation. Serious allergic reactions are rare but possible.

Interactions

Bioflavonoids may interact with certain medications, such as blood thinners, antidepressants, and chemotherapy drugs. It’s important to consult with a healthcare provider before taking bioflavonoid supplements, especially if you are currently taking any prescription medications.

Dosage and Usage

There is no established recommended daily intake for bioflavonoids, as they are not considered an essential nutrient. However, most experts suggest aiming for a daily intake of 500-1,000 mg of bioflavonoids from dietary sources or supplements.

It’s important to follow the dosage instructions on the supplement label and to consult with a healthcare provider before starting any new supplement regimen. Bioflavonoids should not be used as a substitute for prescription medications without the approval of a medical professional.

Natural Sources of Bioflavonoids

Bioflavonoids are found naturally in a variety of plant-based foods, including:

• Citrus fruits (e.g., oranges, lemons, limes, and grapefruits)
• Berries (e.g., blueberries, raspberries, and blackberries)
• Green and black tea
• Red wine
• Soy products
• Dark chocolate
• Herbs and spices (e.g., turmeric, ginger, and parsley)

Incorporating these bioflavonoid-rich foods into your diet can be an effective way to increase your intake of these beneficial plant compounds without the need for supplements.

Conclusion

Bioflavonoids are a fascinating group of plant-based compounds with a wide range of potential health benefits. From their antioxidant properties to their ability to support cardiovascular health and reduce inflammation, bioflavonoids have garnered significant interest in the scientific community and among health-conscious individuals.

While more research is needed to fully understand the mechanisms and long-term effects of bioflavonoid supplementation, incorporating bioflavonoid-rich foods into a balanced diet can be a practical and safe way to potentially reap the benefits of these natural compounds. As with any supplement, it’s important to consult with a healthcare provider before starting a bioflavonoid regimen, especially for individuals with existing medical conditions or taking prescription medications.

Bioflavonoids (Rutin) – Side Effects, Interactions, Uses, Dosage, Warnings

Brand Names:Amino-Opti-C, Limbrel, Pan C 500, Peridin-C, Rutin, Span C

Reviewed: June 23, 2020

Bioflavonoids are found in the rind of green citrus fruits and in rose hips and black currants.

Bioflavonoids have been used in alternative medicine as an antioxidant to treat osteoarthritis and other inflammatory conditions, to support blood circulation and a healthy heart, and enhance the action of vitamin C.

It is not certain whether bioflavonoids is effective in treating any medical condition. Medicinal use of this product has not been approved by the FDA. Bioflavonoids should not be used in place of medication prescribed for you by your doctor.

Bioflavonoids is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

Bioflavonoids may also be used for purposes not listed in this product guide.

uses

What is Bioflavonoids (Rutin) used for?

• Osteoarthritis

warnings

What is the most important information I should know about Bioflavonoids (Rutin)?

Ask a doctor, pharmacist, or other healthcare provider if it is safe for you to use this product if you have ever had:

• a stomach ulcer;
• liver disease; or
• any chronic medical condition.

Ask a doctor before using this medicine if you are pregnant or breastfeeding.

Do not give any herbal/health supplement to a child without the advice of a doctor.

User Reviews & Rating

Overall rating for Bioflavonoids (Rutin)

4.3

out of  5

Side Effects

Easy to Use

Effectiveness

Read Bioflavonoids (Rutin) Reviews

Side Effects

What are the side effects of Bioflavonoids (Rutin)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Common side effects may include:

• blurred vision;
• fast or slow heart rate;
• headache, pounding in your ears;
• dizziness, nervousness;
• skin redness or itching; or
• swelling, pain, or a heavy feeling in your legs or feet.

Less serious side effects may be more likely, and you may have none at all.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pregnancy & Breastfeeding

Can I take Bioflavonoids (Rutin) if I’m pregnant or breastfeeding?

Ask a doctor before using this medicine if you are pregnant or breastfeeding.

Interactions

What drugs and food should I avoid while taking Bioflavonoids (Rutin)?

Avoid using different forms of bioflavonoids (pills, liquids, and others) at the same time.

Dosage Guidelines & Tips

How to take Bioflavonoids (Rutin)?

Use Bioflavonoids (Rutin) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

What should I do if I missed a dose of Bioflavonoids (Rutin)?

Skip the missed dose and take the next regularly scheduled dose.

Overdose Signs

What happens if I overdose on Bioflavonoids (Rutin)?

If you think you or someone else may have overdosed on: Bioflavonoids (Rutin),  call your doctor or the Poison Control center

(800) 222-1222

If someone collapses or isn’t breathing after taking Bioflavonoids (Rutin), call 911

911

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Drugs A-Z provides drug information from Everyday Health and our partners, as well as ratings from our members, all in one place. Cerner Multum™ provides the data within some of the Overview, Uses, Warnings, Side Effects, Pregnancy, Interactions, Dosage, Overdose, and Images sections. The information within all other sections is proprietary to Everyday Health.  

Bioflavonoids Benefits, Best Sources and Side Effects

Fact Checked

This Dr. Axe content is medically reviewed or fact checked to ensure factually accurate information.

With strict editorial sourcing guidelines, we only link to academic research institutions, reputable media sites and, when research is available, medically peer-reviewed studies. Note that the numbers in parentheses (1, 2, etc.) are clickable links to these studies.

The information in our articles is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice.

This article is based on scientific evidence, written by experts and fact checked by our trained editorial staff. Note that the numbers in parentheses (1, 2, etc.) are clickable links to medically peer-reviewed studies.

Our team includes licensed nutritionists and dietitians, certified health education specialists, as well as certified strength and conditioning specialists, personal trainers and corrective exercise specialists. Our team aims to be not only thorough with its research, but also objective and unbiased.

The information in our articles is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice.

By Annie Price, CHHC

June 14, 2017

We know that fruits and vegetables are potent health-promoting items easily within our grasp, but do we know why they’re so incredibly beneficial to our bodies? You probably already knew that they’re rich in vitamins, but you might not have known that they’re also loaded with bioflavonoids. Since the 1990s, there has been a growing interest in dietary bioflavonoids due to their likely contribution to the health benefits of diets rich in fruits and vegetables.

Bioflavonoids, or flavonoids, are a large class of powerful phytochemicals. Not only are bioflavonoids impressive in and of themselves, but they also help maximize the benefits of vitamin C by inhibiting its breakdown in the body. The great thing is that bioflavonoids are often found in many of the top vitamin C foods.

What do broccoli, kale, red onions, hot peppers, rutabaga, spinach and watercress have in common? They’re all vegetables that top the charts, specifically the USDA Flavonoid Database, for their high bioflavonoid content. (1) As such, you should consume these bioflavonoid foods because they’ve been shown to have antiviral, anti-allergy, anti-inflammatory and antitumor abilities. (2)

What Are Bioflavonoids?

Bioflavonoids — aka flavonoids or “vitamin P” — naturally occur in pretty much all fruits, vegetables and herbs. Chocolate, tea and wine, as well as some dry beans and seeds, also contain vitamin P. Flavonoids are a large family of over 5,000 hydroxylated polyphenolic compounds that carry out key functions in plants, such as attracting pollinating insects, fighting environmental stresses and modulating cell growth. In humans, their bioavailability and biological activities appear to be strongly influenced by their chemical nature.

Bioflavonoids can be broken down into several categories. Although dividing them into categories is not universally agreed upon, one common breakdown includes isoflavones, anthocyanidins, flavans, flavonols, flavones and flavanones. Some of the best-known flavonoids, like the quercetin found in onions and the genistein found in soy, can be considered subcategories of categories. (3) Flavonoids also include rutin, citrus flavonoids and hesperidin.

In general, the more colorful a food item is, the richer it is in flavonoids. The ability of flavonoids to positively impact the human body in a large variety of ways appears to be related to their ability to regulate cell signaling. Flavonoids have been shown to exhibit anti-inflammatory, antithrombogenic, antidiabetic, anticancer and neuroprotective activities.

Related: Fisetin: A Senolytic Antioxidant for Healthy Aging & More

Benefits

Bioflavonoids have been scientifically proven to help with the following:

1.

Varicose Veins

Varicose veins occur more commonly in women than men, but up to 60 percent of people in the U.S. have this common health concern. They develop when your veins stretch and their valves, which stop blood from flowing backward, don’t work properly anymore, allowing flood to flow backward and pool in your veins. The good news is that you can fight varicose veins with a healthy diet.

Rutin is a type of bioflavonoid that may support the walls of your veins and help them work better. A number of studies have shown that flavonoids that come from rutin relieve swelling, aching and pain from varicose veins. Rutin is found in fruits and fruit rinds (especially citrus fruits), buckwheat and asparagus.

Additionally, oligomeric proanthocyandin complexes (OPCs) may decrease vein leakage and swelling in the legs. OPCs are bioflavonoids found in grapeseed and pine bark. Similar flavonoids are also found in cranberry, hawthorn, blueberry and other plants. (4)

2.

Hemorrhoids

Up to 75 percent of people experience hemorrhoids at some point in their lives. Hemorrhoids are caused by an increase in pressure on the veins of the anus and rectum. They can be very uncomfortable or even painful, but bioflavonoids are a natural way to prevent and heal unpleasant hemorrhoids.

Studies have shown that bioflavonoids can improve microcirculation, capillary flow and vascular tone, all of which are key in the natural treatment of hemorrhoids. Bioflavonoid consumption can help you avoid the lengthy and possibly expensive complications of hemorrhoids. (5)

3. Cardiovascular Health

Several prospective cohort studies conducted in Europe and the U.S. have examined the relationship between some measure of dietary flavonoid intake and cardiovascular disease.

A recent meta-analysis of 14 prospective studies published between 1996 and 2012 reported that higher intakes in each flavonoid subclass were significantly associated with a reduced risk of cardiovascular issues. (6)

4. Hepatitis

Hepatitis is a a disease characterized by inflammation of the liver. The flavonoid catechin (found in high amounts in matcha green tea) has been shown in some studies to help people suffering from acute viral hepatitis as well as chronic hepatitis. A typical amount of catechin used in successful trials is 500 to 750 milligrams three times per day. (7)

5. Bruises

Bruises to the body occur when blood vessels break, due to some kind of force, and leak blood into areas under the skin. The main symptoms of a bruise are skin pain, skin discoloration and swelling.

Bioflavonoids are often recommended along with vitamin C for people who bruise easily. Bioflavonoids help strengthen the capillaries, which makes them helpful for healing bruises. Bioflavonoids, especially citrus flavonoids, may also increase the effectiveness of vitamin C.

A small, preliminary trial in Germany, conducted by the Department of Dermatology at the Saarland University Hospital and published in the Journal of the American Academy of Dermatology, gave subjects with progressive pigmented purpura (a chronic bruising disorder) 1,000 milligrams per day of vitamin C and 100 milligrams per day of the flavonoid rutin. After four weeks, noticeable bruising was no longer apparent and did not recur in the three-month period after treatment was stopped. (8)

6. Cold Sores

Cold sores are caused by the herpes simplex virus, an infection that may cause only a single cold sore or an outbreak of several cold sores. Until a cold sore is scabbed or crusted, it’s extremely contagious and can even be spread to other parts of the body, including the eyes and genitals. Bioflavonoids combined with vitamin C may help speed cold sore healing.

In one study published in Oral Surgery, Oral Medicine, and Oral Pathology, people with herpes infections received either a placebo or 200 milligrams of vitamin C plus 200 milligrams of flavonoids, each taken three to five times per day. Compared with the placebo, vitamin C and flavonoids reduced the duration of cold sore symptoms by 57 percent. (9) This shows bioflavonoids can naturally treat herpes and cold sores.

7. Allergies

The bioflavonoid quercetin found in onion, citrus fruit, pineapple and buckwheat is very commonly used in the treatment of allergies.  Quercetin is a natural antihistamine and an anti-inflammatory that can lower the effects of seasonal allergy symptoms and food allergies, as well as asthma and skin reactions.

It can help stabilize the release of histamines from certain immune cells, which results in decreased unpleasant allergy symptoms like coughs, watery eyes, runny noses, hives and indigestion. Research published in the Iran Journal of Allergy, Asthma, and Immunology shows that quercetin fights allergies as well as some prescription medications, all with little to no side effects. (10)

8. Hypertension

Many studies have shown that consumption of fruit, vegetables, tea and wine may protect against stroke. The major risk factor for stroke is hypertension or high blood pressure.

A study from the Division of Occupational and Environmental Medicine at theMount Sinai School of Medicine’s Department of Community and Preventive Medicine in New York hypothesized that people with hypertension have lower circulating flavonoid levels, which means that increased consumption of flavonoid-rich foods could decrease rates of hypertension.  Lowering blood pressure through increased dietary consumption of bioflavonoids may decrease the rate of end-organ damage that’s secondary to hypertension. (11)

Another study published in the American Journal of Clinical Nutrition found that certain flavonoids like anthocyanins and some flavone and flavan-3-ol compounds may contribute to the prevention of hypertension. (12)

Related: Apigenin: Top 9 Benefits of the Most Widely Distributed Plant Flavonoid

Top Sources

Consuming fresh fruits, vegetables and herbs is without a doubt the best way to take in bioflavonoids. Chocolate, tea and wine in moderation can also be healthy sources, as are some spices, nuts, dry beans and seeds. Flavonoids are often concentrated in the skins and outer portions of fruits and vegetables so these portions of the foods are excellent to consume. It’s also best to consume fruits, vegetables and herbs in their raw forms to receive the highest amount of flavonoids.

Here are some bioflavonoid-rich food items you’ll want to be taking in regularly:

Fruit

Fresh fruit, especially citrus fruits, berries and tree fruits, are awesome choices when it comes to bioflavonoids. Strawberries, grapes, apples, cranberries and blackberries are high in the bioflavonoid ellagic acid. Citrus fruits like lemons, limes, oranges, tangerines and grapefruits are rich in citrus bioflavonoids. Apples, peaches and plums are rich in the flavonoid flavan-3-ol.

Vegetables

Feel free to eat any and all vegetables, particularly green and red ones, to obtain your daily dose flavonoids. Broccoli, kale, onions (red, yellow and spring), red and hot peppers, rutabaga, spinach, and watercress are some of the heavy hitters when it comes to flavonoids. Red and green onions are especially high in quercetin. Artichokes and celery are high in the flavones, while okra and broccoli are high in flavonols.

Herbs and Spices

Fresh oregano, parsley, peppermint and thyme are high in the flavonoid known as flavone. Cinnamon is a great choice when it comes to spices as well.

Tea

Black, green and red (rooibos) tea are great beverage choices to up your flavonoid intakes. These tea varieties have all been shown to be high in catechins and flavonols. Moringa tea is also a great choice.

Chocolate

Flavanols are the main type of flavonoid found in pure cocoa as well as chocolate (made from cocoa and cocoa butter). One ounce of high-quality dark chocolate — that’s organic with a high cocoa percentage and low sugar content — is a good daily amount.

Wine

Both red and white wine contain flavonoids, but red wine has higher levels since fermentation occurs in the presence of grape skins, the source of significant amounts of flavonoids. So if you drink already, then wine, specifically red wine in moderation, can be a healthy choice. Moderation means not more than one glass per day for women and not more than two glasses per day for men.

Nuts, Beans and Seeds

The soybean is particularly high in bioflavonoid, especially isoflavones like genistein and daidzein. Dark beans — such as black beans and kidney beans, as well as garbanzo, pinto and fava beans — are rich in bioflavonoids. When it comes to nuts, pecans, walnuts, pistachios and cashews are great choices.

Buckwheat is often mistaken for a grain, but it’s actually a nutrient-packed, gluten-free seed that’s particularly high in the bioflavonoids quercetin and rutin.

Bioflavonoids vs. Carotenoids

You might be wondering what the difference is between bioflavonoids and carotenoids. This is understandable, since both come from similar sources and have similar benefits. Here’s how the two stack up:

• The best known phytonutrients are the carotenoids, flavonoids, polyphenols, indoles, lignans and isoflavones.
• Flavonoids are a large family of polyphenolic plant compounds, while carotenoids are yellow, orange and red pigments synthesized by plants.
• Diets high in bioflavonoids and diets high in carotenoids are both associated with reduced risk of cardiovascular disease.
• Dietary flavonoids are naturally occurring in fruit, vegetables, chocolate, and beverages like wine and tea.
• The body can make all the vitamin A it needs from plant-derived carotenoids, while bioflavonoids are commonly found in foods alongside vitamin C. The bioflavonoids help maximize the benefits of vitamin C by inhibiting its breakdown in the body.
• To date, there is hope yet little evidence that flavonoid-rich diets might protect against various cancers, but studies of carotenoids have already shown positive outcomes for lung and prostate cancer.
• Fresh fruits and vegetables are the best sources of bioflavonoids and carotenoids.
• It’s healthiest and safest to obtain both bioflavonoids and carotenoids from dietary sources rather than supplements.
• Carotenoids are best absorbed with fat in a meal. Chopping, puréeing and cooking carotenoid-containing vegetables in oil generally increases the bioavailability of the carotenoids they contain.
• Bioflavonoids are best absorbed from fruits, vegetables and herbs in their raw forms.

Risks and Side Effects

There are no consistent side effects that have been linked with bioflavonoids except for supplemental catechin, which can occasionally cause fever and anemic symptoms from breakdown of red blood cells and hives.

High intakes of dietary flavonoids are generally regarded as safe. However, I don’t recommend extra large amounts of supplemental bioflavonoids, which might be harmful to your health rather than helpful. While obtaining bioflavonoids from food sources is very safe, getting you bioflavonoids from supplements is more controversial.

Some studies have linked large doses of bioflavonoids with childhood leukemia. (12) To be on the safe safe side, it’s best to obtain your bioflavonoids from food rather than supplements, especially if you’re pregnant, nursing or a child.

Bioflavonoid supplements may affect the action of anticoagulants and increase the toxicity of a wide range of drugs when taken concurrently. Talk to your doctor before supplementing with bioflavonoids if you have any ongoing health concerns and currently take other medications.

Final Thoughts

• Fresh fruits and vegetables are the best sources of bioflavonoids.
• Bioflavonoids are also found in herbs, spices, beans, nuts, seeds, tea and wine.
• They’re excellent for the overall health of your entire body at any age.
• Bioflavonoids are best absorbed from fruits, vegetables and herbs in their raw forms.
• They’ve specifically been shown to help prevent and naturally treat varicose veins, hemorrhoids, cardiovascular problems, hepatitis, bruises, cold sores, allergies and hypertension.
• It’s healthiest and safest to obtain bioflavonoids from dietary sources rather than supplements

Vitamin C and bioflavonoids: powerful antioxidants for the eyes

One of the most important components for our body is vitamin C, also known as ascorbic acid. We need its regular use for the general maintenance of immunity, stabilization of the functions of the nervous system, as well as the normal functioning of blood vessels, including those located in the retina of the eye. But what exactly are bioflavonoids and what do they have in common with vitamin C?

In this article

• What are bioflavonoids?
• Where are bioflavonoids found?
• Benefits of Citrus Bioflavonoids
• Which citrus bioflavonoids are best known?
• Products with the highest content of bioflavonoids
• Application and Daily Values ​​
• Important to know

What are bioflavonoids?

Bioflavonoids are harmless chemical compounds of plant origin. They are responsible for the color of fruits, vegetables and plants and contribute to the normalization of capillary permeability. Simply put, bioflavonoids as a kind of “companion” accompany vitamin C, increasing its absorption by the body and efficiency. Scientists have long proven that the combined ingestion of vitamin C and bioflavonoids has a much more pronounced effect than separately.

The uniqueness of these substances lies in the fact that when they enter the mucous membrane or intestinal walls, they acquire an active form and are able to have a huge impact on the regulation process in cellular tissues. To date, researchers have identified more than five thousand of their varieties, which have the same structure and similar properties. All of them differ from each other in color and belong to different categories. So, for example, anthocyanins give red, blue and purple colors, and flavones, chalcones and aurones give orange and yellow.

Where are bioflavonoids found?

Bioflavonoids are found in absolutely all products of plant origin: fruits and vegetables, citrus fruits and natural juice, berries and herbs. For comparison, in products such as bread, eggs, milk, meat and fish, bioflavonoids cannot be contained under any circumstances. That is why we recommend that you eat various vegetable salads as often as possible, as this is not only useful for maintaining body tone, but also for improving visual functions.

If it is not possible to eat them daily, then doctors can prescribe you special preparations with the properties of bioflavonoids. In modern pharmacies, they are presented in a wide range. This makes sense especially in the cold season, when fruits and vegetables rise in price significantly, their useful properties decrease, and people are increasingly asking the question “How can I improve my well-being and boost my immunity?”

Benefits of Citrus Bioflavonoids

As you know, citrus fruits are especially rich in vitamin C and bioflavonoids, respectively. The greatest amount of them is found in the peel of a lemon, orange, tangerine or grapefruit. Citrus bioflavonoids do an excellent job of strengthening the walls of blood vessels, veins and arteries, and are also very strong antioxidants. The use of citrus bioflavonoids has a beneficial effect on increasing the strength of the eye capillaries, stabilizing the heart rate, and lowering cholesterol levels.

In addition, citrus bioflavonoids resist the development of diabetes mellitus, which in turn can lead to a dangerous disease – retinopathy – damage to the eye vessels that provokes retinal dystrophy, optic nerve atrophy and blindness.

Which citrus bioflavonoids are best known?

We have already said above that citrus fruits and bioflavonoids are inextricably linked. The most popular among them are such as rutin, hesperidin and quercetin. Rutin is vitamin P, which is simply indispensable for blood vessels and veins. It helps to strengthen the walls of the capillaries, making them more durable, prevents external bleeding and can be used to treat glaucoma – increased intraocular pressure. It is found not only in citrus fruits, but also in berries, such as raspberries, blackberries, mountain ash or blueberries, as well as red peppers, tomatoes, cabbage and sorrel.

Hesperidin is an active substance, which is characterized by vasoprotective and venotonic properties. In large quantities, it is found in the peel of orange, tangerine and pomelo. The active substance quercetin also belongs to the vitamin P group. It is indispensable in the prevention of common ophthalmic disorders and does an excellent job of preventing sorbitol deposits in the lens, thereby reducing the risk of clouding. Sources are dark varieties of apples, red onions, lingonberries, cranberries, and black currants.

Products with the highest content of bioflavonoids

In addition to citrus fruits, aronia (400 mg per serving), grapes (350 mg), sweet red (about 280 mg per serving) and green peppers (about 130 mg) have the highest content of these substances. A large amount is found in strawberries and broccoli (more than 80 mg). Please note that the values ​​shown are for raw products.

Stuffed or baked peppers, strawberry jam or steamed broccoli will no longer have their original characteristics. In addition, vitamin C loses its properties under the influence of light, so we advise you to purchase citrus juice in opaque containers. According to doctors, the daily children’s dose of vitamin C should be at least 30 mg for children, at least 50 mg for adolescents and men, and at least 40 mg for women. According to rough estimates, this volume is enough to cover the needs of the body.

Application and Daily Values ​​

We have already said that bioflavonoids are found in fruits and vegetables. In addition, a large number of them are also present in fruit juices. Experts recommend enriching your daily diet with these beneficial substances in an amount of at least 2000 mg. However, it is necessary to clarify that this applies only to citrus fruits, since they are characterized by the lowest toxicity. If we consider bioflavonoids derived from green tea or quercetin, then the daily dose should not exceed 400 mg. If we are talking about proanthocyanides – another group of these substances – then their daily norm is no more than 200 mg. Bioflavonoids, like drugs, should not be consumed in large quantities, which is why there are special consumption rates.

Important to know

It must be remembered that even the use of these substances can affect the activity of some medicines. So, for example, grapefruit juice is highly discouraged for the absorption of medicines. They should never take any medication. Among other things, experts do not advise pregnant women to consume bioflavonoids in large quantities, as this can cause leukemia in a newborn baby. Do not forget that an overdose of the substances presented can cause allergic reactions, such as hives, hay fever, or cause breathing difficulties. However, if you strictly follow the recommendations of the attending physician, then no problems will arise.

Bioflavonoids, like most nutrients, are very beneficial to health. They allow you to keep healthy nails and hair, give freshness to the skin, and also prevent many diseases. In addition, their beneficial effect on the functioning of the visual organs has long been proven by experts. It is not at all necessary to purchase expensive drugs if you can keep your body in good shape thanks to bioflavonoids, which are not only affordable, but also very useful.

Why is it important to choose acid-free vitamin C supplemented with bioflavonoids?

Although we have already begun to get used to the situation, and even more so – some of us have developed resistance to what is happening – the idea of ​​​​prevention for the sake of our health has already taken root in our subconscious. What are these assistants (read: nutritional supplements) that could prepare the body for the fight and, if you still happen to get sick, would contribute to recovery, and are they available at all? Consulted by certified gastroenterologist Dr. Zane Straume.

One of the most popular recommendations is to increase vitamin C intake. Doctors justify this with studies showing that vitamin C improves recovery from mild and severe Covid-19. For example, a summary of studies published on January 18, 2021 by researchers at the universities of Helsinki and Amsterdam confirms that vitamin C helps the body fight inflammation, which can also occur in the case of this virus.

Dr. Zane Straume shares his advice on the need for vitamin C: “With food, you can get about 100 mg of vitamin C per day, but in the cold season, the dose should be increased, since this vitamin in our body is assigned a serious function – protecting cells from oxidative stress, as well as help in the functioning of the immune system. Vitamin C accumulates in immune cells, it helps iron and copper to be absorbed in the human body. Interestingly, in a significant proportion of mammals, vitamin C is produced in the body. Unfortunately, in humans, this gene responsible for the synthesis of vitamin C is blocked, so we need to take additional vitamin C.”

However, the gastroenterologist also warns that acidity, which is caused by increased intake of ascorbic acid (the most well-known form of vitamin C), as well as eating acidic foods, changes the pH level in the digestive tract. This process can cause stomach pain and additional irritation, which is especially important for people with stomach problems to be aware of. Therefore, when supplementing with vitamin C, it would be important to pay attention to this aspect and, if possible, choose an acid-free form.

Also, when choosing vitamin C supplements in pharmacies, it is recommended to pay attention to the components that supplement vitamin C, for example, bioflavonoids.

What are bioflavonoids?

This is a group of water-soluble compounds that are also called vitamin P (from the English word “permeability” – ‘permeability’), as this substance contributes to a better absorption of oxygen and nutrients through the walls of the capillaries. These compounds are found in fruits, vegetables, berries and nuts and are actively involved in plant metabolism. Now science knows about 6500 different bioflavonoids. They have a similar chemical structure and biological effect, but differ in intensity. The most famous substances from this group of natural compounds are quercetin, rutin, hesperidin, tangeretin, diosmin and naringin.

What is quercetin and why is it important to take it now?

Bioflavonoid quercetin is considered a powerful natural antioxidant with anti-inflammatory effects, according to a June 2020 study conducted at hospitals and universities in Europe and the United States. It is believed that quercetin is the main element of the Mediterranean diet, as it provides protection to the heart and blood vessels. These studies also confirmed other properties of quercetin, such as slowing down platelet aggregation, inhibiting lipid peroxidation, and reducing the activity of inflammation-forming substances.

Given these abilities of quercetin and the recommendation to take vitamin C along with bioflavonoids, as they promote the absorption of this vitamin and metabolism, at the same time protecting vitamin C from destruction and oxidation, and also helping vitamin C to accumulate in the body, with the onset of the spread of SARS-CoV -2 this compound came to the attention of researchers.

In March 2021, the scientific journal of the University of Beni Suef published conclusions based on a study by Egyptian scientists that quercetin, together with vitamin C, is one of the candidates for creating medicines that will be used for the prevention and treatment of Covid-19. The research team performed a molecular analysis using the three-dimensional structure of the ten major Covid-19 proteins, and assessed the strength of human cells’ interactions with each of these coronavirus proteins by adding quercetin. The results of this study showed that quercetin prevents the virus from binding to human cells through the receptor-binding domain on the surface of the viral spike protein. It is this part of the protein that becomes the target of quercetin, so the coronavirus is neutralized. However, quercetin, by binding to the virus, does not affect the human body. Thus, these results confirm that quercetin may be effective in preventing the entry of coronavirus into human cells.

Acclaimed bioflavonoids – rutin and hesperidin

Rutin is one of the most popular bioflavonoids. It promotes the absorption of ascorbic acid in the digestive organs and its accumulation in tissues, therefore, for better use of ascorbic acid, it is used simultaneously with the gifts of nature, rich in routine, for example, blackcurrant, rose hips, citrus fruits.

The main function of rutin is to strengthen capillary walls and reduce the permeability of blood vessel walls. It is able to prevent and reduce bleeding gums, and also acts as an antioxidant in the body. Studies published in 2018 by the University of Medicine and Health Sciences of South Africa show that rutin has a positive effect on the central nervous system, rutin is recommended to be taken to prevent neurological phenomena such as hypoxia. It is recommended to people after a stroke, as its role in the restoration of sensorimotor abilities after such brain damage has been proven.

Rutin is also being studied as one of the potential agents in the fight against the SARS-CoV-2 virus. Rutin is among the traditional antiviral medicines prescribed in China to infected patients with mild to moderate Covid-19 symptoms.

The bioflavonoid hesperidin has long been known and used in medicine as an anti-inflammatory herbal remedy. It occurs naturally in citrus fruits such as lemons and oranges.

A study published at the end of 2020 by scientists from Tanta University (Egypt) answers the question of whether this bioflavonoid correlates with Covid-19 viral infection. Summing up this study, we can conclude that hesperidin is able to prevent the penetration of the virus into the body through ACE2 receptors, improve host cell immunity, reduce the release of inflammatory mediators and thus protect against pulmonary embolism.

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