What are the primary uses of budesonide-formoterol inhalation. How should patients properly use this medication. What are the potential side effects and precautions associated with budesonide-formoterol. When should patients seek medical attention while using this inhaler.

Understanding Budesonide-Formoterol: A Powerful Combination for Respiratory Health

Budesonide-formoterol is a combination medication used in the treatment of respiratory conditions, primarily asthma and chronic obstructive pulmonary disease (COPD). This inhaler combines two active ingredients: budesonide, a corticosteroid that reduces inflammation in the airways, and formoterol, a long-acting beta-agonist (LABA) that helps to relax and open the airways. Together, these components work synergistically to improve breathing and control symptoms in patients with chronic respiratory issues.

Key Benefits of Budesonide-Formoterol

• Reduces inflammation in the airways
• Provides long-acting bronchodilation
• Helps prevent asthma attacks and COPD exacerbations
• Improves overall lung function and quality of life

By combining these two medications in a single inhaler, patients can benefit from improved adherence to their treatment regimen and potentially better outcomes in managing their respiratory condition.

Proper Administration Techniques for Budesonide-Formoterol Inhalers

Correct usage of the budesonide-formoterol inhaler is crucial for maximizing its therapeutic benefits. Patients should carefully follow the instructions provided by their healthcare provider and the patient information leaflet accompanying the medication.

Step-by-Step Guide to Using Your Inhaler

1. Shake the inhaler well for 5 seconds before each use.
2. Prime the inhaler if it’s new or hasn’t been used for more than 7 days.
3. Exhale fully before placing the mouthpiece between your lips.
4. Inhale deeply and steadily while pressing down on the canister.
5. Hold your breath for 10 seconds, then exhale slowly.
6. If prescribed two puffs, wait at least one minute between doses.
7. Rinse your mouth with water and spit it out after each use.

Can patients use other inhalers along with budesonide-formoterol? Yes, but it’s important to wait at least one minute between using different medications and to use budesonide-formoterol last in the sequence.

Dosage Considerations and Treatment Schedule

The appropriate dosage of budesonide-formoterol is determined by a healthcare professional based on the individual patient’s medical condition and response to treatment. Typically, this medication is prescribed for twice-daily use, with doses taken in the morning and evening, approximately 12 hours apart.

Importance of Consistent Usage

Regular and consistent use of budesonide-formoterol is essential for achieving optimal therapeutic benefits. Patients should strive to take their medication at the same times each day to maintain steady levels of the drug in their system. It’s crucial not to alter the dosage or frequency of use without consulting a healthcare provider first.

Is it safe to stop using budesonide-formoterol abruptly? No, patients should not discontinue use without medical guidance, as this may lead to worsening of respiratory symptoms or withdrawal effects.

Potential Side Effects and Monitoring

While budesonide-formoterol is generally well-tolerated, like all medications, it can cause side effects in some patients. It’s important for users to be aware of potential adverse reactions and to report any concerning symptoms to their healthcare provider promptly.

Common Side Effects

• Headache
• Throat irritation
• Stomach upset
• Hoarseness
• Dry mouth

Serious Side Effects Requiring Medical Attention

• Severe sudden worsening of breathing
• Signs of infection (persistent sore throat, fever)
• Mental/mood changes
• Vision problems
• Chest pain or irregular heartbeat
• Severe dizziness or fainting

How can patients minimize the risk of oral thrush while using budesonide-formoterol? Gargling and rinsing the mouth with water after each use, without swallowing the rinse water, can help prevent oral yeast infections.

Interactions and Precautions

Patients using budesonide-formoterol should be aware of potential drug interactions and take necessary precautions to ensure safe and effective treatment. It’s crucial to inform healthcare providers about all medications, supplements, and herbal products being used.

Key Considerations

• Avoid using other long-acting beta-agonists concurrently
• Inform your doctor about any history of heart problems, high blood pressure, or diabetes
• Be cautious when transitioning from oral corticosteroids to budesonide-formoterol
• Monitor blood pressure regularly, as the medication may cause elevations

Should patients with a history of glaucoma use budesonide-formoterol? Patients with glaucoma or other eye conditions should consult their ophthalmologist before starting this medication, as inhaled corticosteroids may potentially affect intraocular pressure.

Managing Acute Symptoms and Emergency Situations

While budesonide-formoterol is primarily a maintenance medication, patients should be prepared to manage acute symptoms or exacerbations of their respiratory condition. Understanding the difference between controller medications and quick-relief inhalers is crucial for effective symptom management.

Guidelines for Acute Symptom Management

1. Use quick-relief inhalers (e.g., albuterol) for sudden shortness of breath or asthma attacks
2. Monitor peak flow meter readings regularly
3. Be alert to worsening symptoms such as increased coughing, wheezing, or sputum production
4. Seek immediate medical attention for severe breathing difficulties or if quick-relief medications are ineffective

When should patients contact their healthcare provider about worsening symptoms? If quick-relief medications are needed more than twice a week, or if nighttime awakenings due to breathing difficulties increase, it’s time to consult a doctor.

Long-Term Management and Follow-Up Care

Effective long-term management of respiratory conditions with budesonide-formoterol requires ongoing communication with healthcare providers and regular follow-up appointments. These check-ins allow for dosage adjustments, monitoring of side effects, and assessment of overall treatment efficacy.

Key Components of Long-Term Care

• Regular lung function tests
• Periodic review of inhaler technique
• Assessment of symptom control and quality of life
• Monitoring for potential long-term side effects of inhaled corticosteroids
• Adjusting treatment plans as needed based on patient response and lifestyle changes

How often should patients have follow-up appointments while using budesonide-formoterol? The frequency of follow-ups may vary, but typically, patients should see their healthcare provider at least every 3-6 months for routine assessments and more frequently if symptoms are not well-controlled.

Lifestyle Considerations for Optimal Respiratory Health

While budesonide-formoterol plays a crucial role in managing respiratory conditions, patients can further improve their outcomes by adopting healthy lifestyle practices. These complementary strategies can enhance the effectiveness of medication and contribute to overall well-being.

Lifestyle Recommendations for Respiratory Health

• Quit smoking and avoid exposure to secondhand smoke
• Maintain a healthy weight through proper diet and exercise
• Practice stress-reduction techniques such as meditation or yoga
• Keep indoor air clean by using air purifiers and reducing allergens
• Stay up-to-date with vaccinations, especially flu and pneumonia shots

Can dietary changes impact the effectiveness of budesonide-formoterol? While there’s no direct interaction between diet and this medication, a healthy diet rich in antioxidants and omega-3 fatty acids may support overall lung health and potentially enhance the benefits of the inhaler.

In conclusion, budesonide-formoterol is a powerful combination medication that offers significant benefits for patients with chronic respiratory conditions. By understanding proper usage techniques, potential side effects, and the importance of consistent treatment, patients can maximize the therapeutic benefits of this medication. Regular communication with healthcare providers, adherence to prescribed regimens, and adoption of healthy lifestyle practices are key components of successful long-term management. As with any medication, individual responses may vary, and patients should work closely with their healthcare team to tailor their treatment plan for optimal outcomes.

budesonide-formoterol inhalation: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

How to use Budesonide-Formoterol HFA 80 Mcg-4.5 Mcg/Actuation Aerosol Inhaler Orally Inhaled Steroids

Read the Patient Information Leaflet and Instructions for Use provided by your pharmacist before you start using this medication and each time you get a refill. Follow the illustrated directions for the proper use of this medication. If you have any questions, ask your doctor or pharmacist.

Follow the instructions for priming the inhaler if you are using it for the first time, if you have not used it for more than 7 days, or if the inhaler was dropped. When priming the inhaler, make sure to spray away from the face so that you do not get the medication into your eyes.

Shake the inhaler well for 5 seconds before each use. Inhale this medication by mouth as directed by your doctor, usually twice daily (in the morning and evening, 12 hours apart).

If your prescribed dose is 2 puffs, wait at least one minute between them. If you are using other inhalers at the same time, wait at least 1 minute between the use of each medication, and use this drug last.

To prevent dry mouth, hoarseness, and oral yeast infections from developing, gargle, rinse your mouth with water and spit out after each use. Do not swallow the rinse water.

Clean the inhaler once a week with a dry cloth. Do not take the inhaler apart.

The dosage is based on your medical condition and response to treatment.

Use this medication regularly in order to get the most benefit from it. This medication works best if used at evenly spaced times. To help you remember, use it at the same times each day. Do not increase your dose, use this medication more often, or stop using it without first consulting your doctor. Also, do not use other long-acting beta agonists while using this medication.

If you are regularly taking a different corticosteroid by mouth (such as prednisone), you should not stop taking it unless directed by your doctor. Some conditions (such as asthma, allergies) may become worse when the drug is suddenly stopped. If you suddenly stop taking the drug, you may also have withdrawal symptoms (such as weakness, weight loss, nausea, muscle pain, headache, tiredness, dizziness). To help prevent withdrawal, your doctor may slowly lower the dose of your old medication after you begin using budesonide/formoterol. Tell your doctor or pharmacist right away if you have withdrawal. See also Precautions section.

If you have been using a quick-relief inhaler (such as albuterol, also called salbutamol in some countries) on a regular daily schedule (such as 4 times daily), you must stop this schedule and only use the quick-relief inhaler as needed for sudden shortness of breath/asthma attacks. Consult your doctor for details.

It may take 1 week or longer before you get the full benefit of this drug. Tell your doctor if your symptoms do not improve or if they worsen.

Learn which of your inhalers you should use every day (controller drugs) and which you should use if your breathing suddenly worsens (quick-relief drugs). Ask your doctor ahead of time what you should do if you have new or worsening cough or shortness of breath, wheezing, increased sputum, worsening peak flow meter readings, waking up at night with trouble breathing, if you use your quick-relief inhaler more often (more than 2 days a week), or if your quick-relief inhaler does not seem to be working well. Learn when you can treat sudden breathing problems by yourself and when you must get medical help right away.

Side Effects

Headache, throat irritation, or stomach upset may occur. If any of these effects last or get worse, tell your doctor promptly.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high.

Rarely, this medication may cause severe sudden worsening of breathing problems/asthma immediately after use. If you have sudden worsening of breathing, use your quick-relief inhaler and get medical help right away.

Tell your doctor right away if you have any serious side effects, including: white patches on tongue/in mouth, signs of infection (such as sore throat that doesn’t go away, fever), mental/mood changes (such as nervousness), trouble sleeping, vision problems (such as blurred vision), increased thirst/urination, muscle cramps, shaking (tremors).

Get medical help right away if you have any very serious side effects, including: chest pain, fast/slow/irregular heartbeat, severe dizziness, fainting, seizures.

A very serious allergic reaction to this product is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, sudden trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before using this medication, tell your doctor or pharmacist if you are allergic to budesonide or formoterol; or to arformoterol; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: current/past infections (such as tuberculosis, herpes), high blood pressure, heart disease (such as chest pain, heart attack, irregular heartbeat), overactive thyroid (hyperthyroidism), seizures, bone loss (osteoporosis), eye problems (such as cataracts, glaucoma), diabetes, liver disease, swelling of an artery (aneurysm), a certain tumor of the adrenal gland (pheochromocytoma).

Formoterol may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using this product, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/”water pills”) or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using this medication safely.

This medication may mask signs of infection. It can make you more likely to get infections or may make current infections worse. Stay away from anyone who has an infection that may easily spread (such as chickenpox, COVID-19, measles, flu). Talk to your doctor if you have been exposed to an infection or for more details.

If you have switched from a corticosteroid taken by mouth (such as prednisone tablets) to this inhaler within the past 12 months, or if you have been using this product in higher-than-usual doses for a long time, it may be more difficult for your body to respond to physical stress. Before having surgery or emergency treatment, or if you get a serious illness/injury, tell your doctor or dentist that you are using this medication or have used a corticosteroid taken by mouth within the past 12 months. Tell your doctor right away if you develop unusual/extreme tiredness or weight loss. Carry a warning card or medical ID bracelet that says you use (or have used) corticosteroid medications.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This medication may temporarily slow down a child’s growth if used for a long time. However, poorly controlled asthma can also slow down growth. See the doctor regularly so your child’s height can be checked.

Older adults may be more sensitive to the side effects of this drug, especially QT prolongation (see above).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

Budesonide passes into breast milk. It is unknown if formoterol passes into breast milk. Consult your doctor before breast-feeding.

Consult your pharmacist or physician.

Interactions

See also Uses section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug include: aldesleukin, mifepristone.

Does Budesonide-Formoterol HFA 80 Mcg-4.5 Mcg/Actuation Aerosol Inhaler Orally Inhaled Steroids interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: shaking (tremors), chest pain, fast/irregular heartbeat, seizures.

Do not share this medication with others.

Lab and/or medical tests (such as lung function, blood pressure, bone density tests, eye exams) may be done while you are using this medication. Keep all medical and lab appointments. Consult your doctor for more details.

Learn to use a peak flow meter, use it daily, and promptly report worsening asthma or other breathing problems (such as readings in the yellow/red range or increased use of quick-relief inhalers).

Avoid allergens/irritants such as smoke, pollen, pet dander, dust, and molds that may worsen asthma and other breathing problems. Because the flu virus can also worsen breathing problems, ask your doctor or pharmacist if you should have a flu shot every year.

In adults, this medication can increase the risk of bone loss (osteoporosis) if used for a long time. Talk with your doctor about your risk, and about available treatments for osteoporosis. Lifestyle changes that reduce the risk of bone loss include doing weight-bearing exercise, getting enough calcium and vitamin D, stopping smoking, and limiting alcohol. To help prevent osteoporosis later in life, encourage children to exercise and eat a healthy diet (including calcium).

If you miss a dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light, heat, and moisture. Do not store in the bathroom. Store the inhaler with the mouthpiece down. Do not puncture the canister or use near an open flame. Keep all medications away from children and pets. Do not remove the inhaler from its original foil package until ready to use. Discard the inhaler 3 months after you remove it from the original foil package or after all the doses have been used, whichever comes first.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details.

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budesonide-formoterol HFA 80 mcg-4. 5 mcg/actuation aerosol inhaler

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This medicine is a white, aerosol

budesonide-formoterol HFA 160 mcg-4.5 mcg/actuation aerosol inhaler

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

SYMBICORT® (budesonide/formoterol fumarate dihydrate) Inhalation Aerosol

IMPORTANT SAFETY INFORMATION

• Use of long-acting beta₂-adrenergic agonists (LABA) as monotherapy (without inhaled corticosteroids [ICS]) for asthma is associated with an increased risk of asthma-related death. Available data from controlled clinical trials also suggest that use of LABA as monotherapy increases the risk of asthma-related hospitalization in pediatric and adolescent patients. These findings are considered a class effect of LABA. When LABA are used in fixed dose combination with ICS, data from large clinical trials do not show a significant increase in the risk of serious asthma-related events (hospitalizations, intubations, death) compared to ICS alone
• SYMBICORT is NOT a rescue medication and does NOT replace fast-acting inhalers to treat acute symptoms
• SYMBICORT should not be initiated in patients during rapidly deteriorating episodes of asthma or COPD
• Patients who are receiving SYMBICORT should not use additional formoterol or other LABA for any reason
• Localized infections of the mouth and pharynx with Candida albicans has occurred in patients treated with SYMBICORT. Patients should rinse the mouth after inhalation of SYMBICORT
• Lower respiratory tract infections, including pneumonia, have been reported following the administration of ICS
• Due to possible immunosuppression, potential worsening of infections could occur. A more serious or even fatal course of chickenpox or measles can occur in susceptible patients
• It is possible that systemic corticosteroid effects such as hypercorticism and adrenal suppression may occur, particularly at higher doses. Particular care is needed for patients who are transferred from systemically active corticosteroids to ICS. Deaths due to adrenal insufficiency have occurred in asthmatic patients during and after transfer from systemic corticosteroids to less systemically available ICS
• Caution should be exercised when considering administration of SYMBICORT in patients on long-term ketoconazole and other known potent CYP3A4 inhibitors
• As with other inhaled medications, paradoxical bronchospasm may occur with SYMBICORT
• Immediate hypersensitivity reactions may occur, as demonstrated by cases of urticaria, angioedema, rash, and bronchospasm
• Excessive beta-adrenergic stimulation has been associated with central nervous system and cardiovascular effects. SYMBICORT should be used with caution in patients with cardiovascular disorders, especially coronary insufficiency, cardiac arrhythmias, and hypertension
• Long-term use of ICS may result in a decrease in bone mineral density (BMD). Since patients with COPD often have multiple risk factors for reduced BMD, assessment of BMD is recommended prior to initiating SYMBICORT and periodically thereafter
• ICS may result in a reduction in growth velocity when administered to pediatric patients
• Glaucoma, increased intraocular pressure, and cataracts have been reported following the administration of ICS, including budesonide, a component of SYMBICORT. Close monitoring is warranted in patients with a change in vision or history of increased intraocular pressure, glaucoma, or cataracts
• In rare cases, patients on ICS may present with systemic eosinophilic conditions
• SYMBICORT should be used with caution in patients with convulsive disorders, thyrotoxicosis, diabetes mellitus, ketoacidosis, and in patients who are unusually responsive to sympathomimetic amines
• Beta-adrenergic agonist medications may produce hypokalemia and hyperglycemia in some patients
• The most common adverse reactions ≥3% reported in asthma clinical trials included nasopharyngitis, headache, upper respiratory tract infection, pharyngolaryngeal pain, sinusitis, pharyngitis, rhinitis, influenza, back pain, nasal congestion, stomach discomfort, vomiting, and oral candidiasis
• The most common adverse reactions ≥3% reported in COPD clinical trials included nasopharyngitis, oral candidiasis, bronchitis, sinusitis, and upper respiratory tract infection
• SYMBICORT should be administered with caution to patients being treated with MAO inhibitors or tricyclic antidepressants, or within 2 weeks of discontinuation of such agents
• Beta-blockers may not only block the pulmonary effect of beta-agonists, such as formoterol, but may produce severe bronchospasm in patients with asthma
• ECG changes and/or hypokalemia associated with nonpotassium-sparing diuretics may worsen with concomitant beta-agonists. Use caution with the coadministration of SYMBICORT

INDICATIONS

• SYMBICORT is indicated for the treatment of asthma in patients 6 years and older not adequately controlled on a long-term asthma-control medication such as an ICS or whose disease warrants initiation of treatment with both an ICS and LABA (also see DOSAGE AND ADMINISTRATION).
• SYMBICORT 160/4.5 is indicated for the maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema, and to reduce COPD exacerbations.
• SYMBICORT is NOT indicated for the relief of acute bronchospasm.

Please see full Prescribing Information , including Patient Information.

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Budesonide + Formoterol – description of the substance, pharmacology, use, contraindications, formula

Budesonide + Formoterol – description of the substance, pharmacology, use, contraindications, formula

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Contents

• Russian name

• English name

• Latin name

• Pharmacological group of the substance Budesonide + Formoterol

• Trade names with the active substance Budesonide + Formoterol

Russian name

Budesonide + Formoterol

English name

Budesonide + Formoterol

Latin name

Budesonidum + Formoterolum ( born Budesonidi + Formoteroli)

Pharmacological group of the substance Budesonide + Formoterol

Beta-agonists in combinations

Trade names with active substance Budesonide + Formoterol

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Lek. form
All lek. forms aerosol for inhalation dosed capsules with powder for inhalation capsules with powder for inhalation set powder for inhalation dosed

Dosage
All dosages 160mcg+4.5mcg/dose 160/4.5mcg/dose 200mcg+12mcg 200mcg/12mcg 320mcg+9mcg/dose 400mcg+12mcg 400mcg/12mcg 80mcg+4.5mcg/dose 80 /4.5 µg/dose

Manufacturer
All manufacturers AstraZeneca AB AstraZeneca Dunkirk Production Siegfried Barbera S.L. Nativa LLC Novartis Pharma Stein AG Novartis Pharmaceuticals Norton (Waterford) PSK Pharma Pharmaceuticals LLC Pharmstandard-Leksredstva

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R03AK07 Formoterol and budesonide are included in the group

Anatomo-Therapeutic-Chemical (ATC) classification system (ATC)

ATX code:
R03AK07

Part of the group:
R03AK-
Adrenergic drugs in combination with glucocorticoids or drugs other than anticholinergics

Name:
Formoterol and budesonide

Group drugs