What are the uses of Butalbital-Acetaminophen-Caffeine. How does this medication work. What are the potential side effects and precautions. What is the recommended dosage for Butal Acet Caff 50 325. How should this medication be taken safely.

Understanding Butal Acet Caff 50 325: Composition and Mechanism of Action

Butal Acet Caff 50 325 is a combination medication containing three active ingredients: butalbital, acetaminophen, and caffeine. Each component plays a specific role in managing tension headaches:

• Butalbital (50 mg): A barbiturate that relaxes muscle contractions associated with tension headaches
• Acetaminophen (325 mg): A pain reliever and fever reducer
• Caffeine (40 mg): A central nervous system stimulant that improves blood flow by relaxing blood vessel contractions

This unique combination targets multiple aspects of tension headaches, providing comprehensive relief for many patients. How does each component contribute to the overall effectiveness of the medication?

Butalbital, as a barbiturate, acts on the central nervous system to induce relaxation and reduce anxiety. This helps alleviate the muscle tension often associated with tension headaches. Acetaminophen works by inhibiting the production of prostaglandins, chemicals in the body that cause pain and inflammation. Caffeine enhances the pain-relieving effects of acetaminophen and may also improve mood and alertness.

Medical Uses and Indications for Butal Acet Caff 50 325

The primary indication for Butal Acet Caff 50 325 is the treatment of tension headaches. These headaches are characterized by a dull, aching pain often described as a tight band around the head. When are tension headaches most likely to occur?

Tension headaches frequently arise from stress, anxiety, poor posture, or prolonged focus on tasks such as computer work. They can be episodic (occurring less than 15 days per month) or chronic (occurring 15 or more days per month).

While Butal Acet Caff 50 325 is primarily prescribed for tension headaches, it may also be used off-label for other conditions at the discretion of a healthcare provider. These may include:

• Migraine headaches
• Post-dural puncture headaches
• Dental pain

It’s crucial to note that this medication should only be used under the guidance of a healthcare professional due to its potential for dependence and side effects.

Dosage Guidelines and Administration

The appropriate dosage of Butal Acet Caff 50 325 can vary depending on individual factors such as age, weight, and medical history. However, general guidelines for adults typically include:

• 1-2 tablets or capsules every 4 hours as needed
• Maximum of 6 tablets or capsules per day
• Do not exceed 4000 mg of acetaminophen in 24 hours from all sources

How should this medication be taken for optimal effectiveness and safety?

Butal Acet Caff 50 325 can be taken with or without food. If stomach upset occurs, taking it with food may help alleviate this side effect. It’s essential to follow the prescribed dosage carefully and not exceed the recommended amount, as overdose can lead to severe liver damage or other complications.

Patients should be aware that this medication contains butalbital, which can be habit-forming. Therefore, it’s crucial to use it exactly as prescribed and not increase the dose or frequency without consulting a healthcare provider.

Special Dosing Considerations

Certain populations may require adjusted dosing or should avoid this medication altogether:

• Elderly patients: May require lower doses due to increased sensitivity to side effects
• Patients with liver or kidney disease: May need dose adjustments or alternative treatments
• Pregnant or breastfeeding women: Should avoid this medication due to potential risks to the fetus or infant
• Children under 12 years old: Not approved for use in this age group

Potential Side Effects and Adverse Reactions

While Butal Acet Caff 50 325 can be effective for managing tension headaches, it’s important to be aware of potential side effects. Common side effects may include:

• Drowsiness or dizziness
• Lightheadedness
• Nausea or stomach discomfort
• Shortness of breath
• Anxiety or restlessness

What are some of the more serious side effects that require immediate medical attention?

Serious side effects, although rare, can occur and may include:

• Severe allergic reactions (rash, itching, swelling, difficulty breathing)
• Signs of liver problems (dark urine, clay-colored stools, jaundice)
• Unusual bleeding or bruising
• Confusion or mood changes
• Severe skin reactions (blistering, peeling)

Patients should seek immediate medical attention if they experience any of these severe side effects. It’s also important to note that long-term use of this medication can lead to dependence and withdrawal symptoms upon discontinuation.

Drug Interactions and Precautions

Butal Acet Caff 50 325 can interact with various medications and substances, potentially altering its effectiveness or increasing the risk of side effects. What are some of the most important drug interactions to be aware of?

Key interactions include:

• MAO inhibitors: Can cause dangerous interactions if taken within 14 days of each other
• Other CNS depressants: May enhance sedative effects
• Blood thinners: Can increase the risk of bleeding
• Alcohol: Can increase the risk of liver damage and enhance sedative effects

Patients should always inform their healthcare provider about all medications, supplements, and herbal products they are taking before starting Butal Acet Caff 50 325.

Precautions and Contraindications

Certain conditions may preclude the use of this medication or require special consideration:

• History of substance abuse or addiction
• Liver disease or alcohol abuse
• Kidney disease
• History of mental illness or suicidal thoughts
• Porphyria
• Pregnancy or breastfeeding

Healthcare providers should carefully weigh the potential benefits against the risks when considering prescribing this medication to patients with these conditions.

Monitoring and Follow-up Care

Regular monitoring is essential for patients taking Butal Acet Caff 50 325, especially those using it for extended periods. What aspects of a patient’s health should be closely monitored during treatment?

Key areas for monitoring include:

• Liver function: Regular liver enzyme tests may be recommended
• Kidney function: Particularly important for patients with pre-existing kidney issues
• Mental health: Watch for signs of depression or suicidal thoughts
• Pain management effectiveness: Assess whether the medication is providing adequate relief
• Signs of dependence or tolerance: Monitor for increasing dosage needs or withdrawal symptoms

Patients should have regular follow-up appointments with their healthcare provider to assess the ongoing need for the medication and to address any concerns or side effects.

Alternative Treatments and Complementary Approaches

While Butal Acet Caff 50 325 can be effective for managing tension headaches, it’s not the only treatment option available. What are some alternative approaches that patients might consider?

Alternative treatments for tension headaches may include:

• Non-opioid pain relievers: Such as ibuprofen or naproxen
• Stress management techniques: Including meditation, yoga, or cognitive-behavioral therapy
• Physical therapy: To address muscle tension and improve posture
• Acupuncture: Some patients find relief through this traditional Chinese medicine practice
• Lifestyle modifications: Such as improving sleep habits, regular exercise, and dietary changes

Patients should discuss these options with their healthcare provider to determine the most appropriate treatment plan for their individual needs.

Complementary Approaches

In addition to or in conjunction with medication, some patients find relief through complementary approaches such as:

• Massage therapy
• Biofeedback
• Essential oil aromatherapy
• Heat or cold therapy
• Herbal supplements (with caution and under medical supervision)

It’s important to note that while these complementary approaches may provide relief for some patients, they should be used in consultation with a healthcare provider to ensure safety and effectiveness.

Long-term Considerations and Prognosis

For patients using Butal Acet Caff 50 325 over an extended period, it’s crucial to consider the long-term implications of this treatment. What are some of the key considerations for long-term use?

Long-term considerations include:

• Risk of dependence: Butalbital can be habit-forming, leading to physical and psychological dependence
• Tolerance development: Patients may require higher doses over time to achieve the same effect
• Liver health: Long-term use of acetaminophen can potentially impact liver function
• Rebound headaches: Overuse of headache medication can lead to medication overuse headaches
• Impact on daily functioning: Sedative effects may affect work or driving ability

Healthcare providers should work with patients to develop a long-term management plan that balances effective pain relief with minimizing potential risks. This may involve periodic attempts to reduce or discontinue the medication, exploring alternative treatments, or implementing strategies to prevent the progression of episodic headaches to chronic headaches.

Prognosis and Quality of Life

The prognosis for patients with tension headaches treated with Butal Acet Caff 50 325 can vary widely depending on individual factors. Many patients experience significant relief and improved quality of life with appropriate use of this medication. However, it’s important to address underlying causes of tension headaches, such as stress or poor posture, to achieve long-term improvement.

Patients who develop effective coping strategies, in addition to using medication when necessary, often have the best outcomes. This may involve a combination of pharmacological treatment, lifestyle modifications, and stress management techniques.

Regular follow-up with healthcare providers is essential to assess the ongoing effectiveness of the treatment plan and make adjustments as needed. By taking a comprehensive approach to headache management, many patients can achieve significant improvements in their symptoms and overall quality of life.

Acetaminophen, butalbital, and caffeine Uses, Side Effects & Warnings

Generic name: acetaminophen, butalbital, and caffeine [ a-SEET-a-MIN-oh-fen, bue-TAL-bi-tal, and-KAF-een ]
Brand names: Esgic, Fioricet, Zebutal, Esgic-Plus, Arcet,
… show all 37 brands
Isocet, Pharmagesic, Anoquan, Two-Dyne, Tenake, Margesic, Anolor 300, Femcet, Geone, Tencet, Triad, Fiorpap, Repan, Dolmar, Endolor, Ezol, Ide-cet, G-1, Medigesic, Minotal, Mygracet, Pacaps, Alagesic, Americet, Nonbac, Dolgic LQ, Dolgic Plus, Orbivan, Capacet, Vanatol LQ, Vanatol S, Vtol LQ

Dosage forms: oral capsule (300 mg-50 mg-40 mg; 325 mg-50 mg-40 mg), oral liquid (325 mg-50 mg-40 mg/15 mL), oral tablet (325 mg-50 mg-40 mg)
Drug class: Analgesic combinations

Medically reviewed by Drugs.com on Jan 21, 2022. Written by Cerner Multum.

What is acetaminophen, butalbital, and caffeine?

Acetaminophen is a pain reliever and fever reducer.

Butalbital is in a group of drugs called barbiturates. It relaxes muscle contractions involved in a tension headache.

Caffeine is a central nervous system stimulant. It relaxes muscle contractions in blood vessels to improve blood flow.

Acetaminophen, butalbital, and caffeine is a combination medicine used to treat tension headaches that are caused by muscle contractions.

Acetaminophen, butalbital, and caffeine may also be used for purposes not listed in this medication guide.

Warnings

Do not use this medcine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, and tranylcypromine.

Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death. Call your doctor at once if you have nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of your skin or eyes).

In rare cases, acetaminophen may cause a severe skin reaction. Stop taking acetaminophen, butalbital, and caffeine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.

Before taking this medicine

Do not use this medicine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

You should not use acetaminophen, butalbital, and caffeine if you are allergic to it, if you have porphyria, or if you have recently used alcohol, sedatives, tranquilizers, or other opioids.

Tell your doctor if you have ever had:

• liver disease, cirrhosis, a history of alcoholism or drug addiction, or if you drink more than 3 alcoholic beverages per day;

• kidney disease;

• stomach ulcer or bleeding;

• a history of skin rash caused by any medication; or

• a history of mental illness or suicidal thoughts.

It is not known whether this medicine will harm an unborn baby. If you use butalbital while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks. Tell your doctor if you are pregnant or plan to become pregnant.

This medicine can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breastfeeding a baby.

Not approved for use by anyone younger than 12 years old.

How should I take acetaminophen, butalbital, and caffeine?

Follow all directions on your prescription label. Do not take more of this medication than recommended. An overdose can damage your liver or cause death. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

Butalbital may be habit-forming. Never share acetaminophen, butalbital, and caffeine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law.

Store at room temperature away from moisture and heat.

Keep track of the amount of medicine used from each new bottle. Butalbital is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

What happens if I miss a dose?

Since this medicine is used when needed, you may not be on a dosing schedule. If you are on a schedule, use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of acetaminophen, butalbital, and caffeine can be fatal.

The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.

Overdose symptoms may also include insomnia, restlessness, tremor, diarrhea, increased shallow breathing, uneven heartbeats, seizure (convulsions), or fainting.

What should I avoid while taking acetaminophen, butalbital, and caffeine?

This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen.

Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.

While you are taking this medication, avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor’s advice.

Acetaminophen, butalbital, and caffeine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking acetaminophen, butalbital, and caffeine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never again take any medicine that contains acetaminophen.

This medicine may cause serious side effects. Stop using this medicine and call your doctor at once if you have:

• confusion, a seizure;

• shortness of breath;

• a light-headed feeling, like you might pass out; or

• nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects of acetaminophen, butalbital, and caffeine may include:

• drowsiness, dizziness;

• feeling light-headed;

• nausea, vomiting, stomach pain;

• drunk feeling; or

• shortness of breath.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Acetaminophen, butalbital, and caffeine dosing information

Usual Adult Dose for Headache:

Butalbital 50 mg/acetaminophen 300 mg/caffeine 40 mg: 1 or 2 capsules orally every 4 hours as needed not to exceed 6 capsules per day

Butalbital 50 mg/acetaminophen 325 mg/caffeine 40 mg: 1 or 2 capsules or tablets orally every 4 hours as needed not to exceed 6 capsules or tablets per day

Butalbital 50 mg/acetaminophen 325 mg/caffeine per 15 mL oral liquid: 15 to 30 mL orally every 4 hours as needed not to exceed 90 mL per day

Comments:
-Due to high rate of physical dependence, the extended use of this drug is not recommended.
-The safety and efficacy of treating multiple recurrent headaches with this product is not known.

Uses: For the relief of the symptom complex of tension (or muscle contraction) headache.

Usual Pediatric Dose for Headache:

12 years or older:

Butalbital 50 mg/acetaminophen 300 mg/caffeine 40 mg: 1 or 2 capsules orally every 4 hours as needed not to exceed 6 capsules per day

Butalbital 50 mg/acetaminophen 325 mg/caffeine 40 mg: 1 or 2 capsules or tablets orally every 4 hours as needed not to exceed 6 capsules or tablets per day

Butalbital 50 mg/acetaminophen 325 mg/caffeine per 15 mL oral liquid: 15 to 30 mL orally every 4 hours as needed not to exceed 90 mL per day

Comments:
-Due to high rate of physical dependence, the extended use of this drug is not recommended.
-The safety and efficacy of treating multiple recurrent headaches with this product is not known.

Uses: For the relief of the symptom complex of tension (or muscle contraction) headache.

What other drugs will affect acetaminophen, butalbital, and caffeine?

Taking this medicine with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before taking acetaminophen, butalbital, and caffeine with a sleeping pill, opioid pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Other drugs may affect acetaminophen, butalbital, and caffeine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

More about acetaminophen / butalbital / caffeine

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• Butalbital, Acetaminophen, and Caffeine Capsules and Tablets
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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Copyright 1996-2023 Cerner Multum, Inc. Version: 8.01.

Acetaminophen, Butalbital, and Caffeine: MedlinePlus Drug Information

pronounced as (a set a mee’ noe fen) (byoo tal’ bi tal) (kaf’ een)

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This combination of drugs is used to relieve tension headaches.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

The combination of acetaminophen, Butalbital, Caffeine comes as a capsule and tablet to take by mouth. It usually is taken every 4 hours as needed. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take acetaminophen, Butalbital, Caffeine exactly as directed. Do not take more than six tablets or capsules in 1 day. If you think that you need more to relieve your symptoms, call your doctor.

This medication can be habit-forming. Do not take a larger dose, take it more often, or for a longer period than your doctor tells you to.

Before taking acetaminophen, Butalbital, Caffeine,

• tell your doctor and pharmacist if you are allergic to acetaminophen, butalbital, caffeine, or any other drugs.
• tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially anticoagulants (‘blood thinners’) such as warfarin (Coumadin), antidepressants, antihistamines, pain medications, sedatives, sleeping pills, tranquilizers, and vitamins. Many nonprescription pain relievers contain acetaminophen. Too much of this drug can be harmful.
• tell your doctor if you have or have ever had liver disease, porphyria, or depression.
• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking this medication, call your doctor.
• you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you.
• remember that alcohol can add to the drowsiness caused by this drug.

Acetaminophen, Butalbital, Caffeine may cause an upset stomach. Take this medicine with food or milk.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Acetaminophen, Butalbital, Caffeine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• drowsiness
• upset stomach
• vomiting
• stomach pain
• depression
• lightheadedness
• confusion

If you experience any of the following symptoms, call your doctor immediately:

• skin rash
• itching
• difficulty breathing

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online (http://www. fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature, away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.

• Alagesic^®¶
• Americet^®¶
• Anolor^®¶
• Anoquan^®¶
• Arcet^®¶
• Dolgic^®¶
• Dolmar^®¶
• Endolor^®¶
• Esgic^®¶
• Ezol^®¶
• Femcet^®¶
• Fioricet^®
• Fiorpap^®¶
• G-1^®¶
• Ide-cet^®¶
• Isocet^®¶
• Margesic^®¶
• Medigesic^®¶
• Minotal^®¶
• Mygracet^®¶
• Nonbac^®¶
• Pacaps^®¶
• Pharmagesic^®¶
• Quala Cet^®¶
• Repan^®¶
• Tenake^®¶
• Tencet^®¶
• Triad^®¶
• Two-Dyne^®¶
• Zebutal^®¶

• Esgic^® Plus (containing Acetaminophen, Butalbital, Caffeine, Codeine)
• Geone^® (containing Acetaminophen, Butalbital, Caffeine)^¶
• Orbivan^® (containing Acetaminophen, Butalbital, Caffeine)^¶
• Fioricet^® with Codeine (containing Acetaminophen, Butalbital, Caffeine, Codeine)
• Phrenilin^® with Caffeine and Codeine (containing Acetaminophen, Butalbital, Caffeine, Codeine)

^¶ This branded product is no longer on the market. Generic alternatives may be available.

Last Revised – 05/15/2019

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