Can Effexor cause weight gain. How does Effexor affect body weight. What are the potential side effects of Effexor. How to manage weight while taking antidepressants. Are there alternatives to Effexor with fewer weight-related side effects.

What Is Effexor and How Does It Work?

Effexor, containing the active ingredient venlafaxine, is an antidepressant medication used to treat various mental health conditions, including major depressive disorder (MDD), generalized anxiety disorder (GAD), social anxiety disorder (SAD), and panic disorder (PD). Originally approved by the FDA in 1993, Effexor is now primarily available as the extended-release formulation Effexor XR® or as generic venlafaxine.

Venlafaxine belongs to a class of antidepressants known as serotonin-norepinephrine reuptake inhibitors (SNRIs). These medications work by altering the levels of certain neurotransmitters in the brain, specifically serotonin and norepinephrine.

The Role of Serotonin and Norepinephrine

• Serotonin: Regulates mood, happiness, anxiety levels, and sleep cycles
• Norepinephrine: Enhances attention, focus, memory formation, and mental alertness

By increasing the levels of these neurotransmitters, Effexor XR and generic venlafaxine aim to reduce the severity of depression and anxiety symptoms. In addition to its approved uses, venlafaxine is sometimes prescribed off-label for conditions such as hot flashes, chronic pain, and premenstrual dysphoric disorder (PMDD).

Effexor and Weight Changes: What Does the Research Say?

While weight gain is often associated with antidepressant use, the relationship between Effexor and weight changes is more complex. Unlike many older antidepressants, Effexor is not commonly linked to significant weight gain. In fact, some scientific research suggests that Effexor may be more likely to contribute to mild weight loss than noticeable weight gain.

Comparing Effexor to Other Antidepressants

To understand the potential weight-related effects of Effexor, it’s helpful to compare it to other types of antidepressants:

1. Selective Serotonin Reuptake Inhibitors (SSRIs): Modern, first-line treatments that increase serotonin levels
2. Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs): Newer medications like Effexor that increase both serotonin and norepinephrine levels
3. Tricyclic Antidepressants (TCAs): Older medications with a higher risk of side effects, including weight gain

While TCAs are more commonly associated with weight gain, newer antidepressants like SSRIs and SNRIs generally have a lower risk of this side effect. Effexor, as an SNRI, falls into this category of medications with a potentially lower likelihood of causing significant weight changes.

Factors Influencing Weight Changes on Effexor

Although Effexor may not directly cause significant weight gain in most patients, individual responses to the medication can vary. Several factors may influence weight changes while taking Effexor:

• Individual metabolism and body chemistry
• Pre-existing health conditions
• Dietary habits and physical activity levels
• Dosage and duration of treatment
• Concurrent use of other medications

It’s important to note that changes in weight, whether gain or loss, can also be a symptom of depression itself. As Effexor helps manage depressive symptoms, some patients may experience weight changes as their overall mental health improves.

Managing Weight While Taking Effexor

For individuals concerned about potential weight changes while taking Effexor, there are several strategies to maintain a healthy weight:

1. Monitor Your Diet

Keeping a food diary can help you track your calorie intake and identify any changes in eating habits. Focus on consuming a balanced diet rich in fruits, vegetables, lean proteins, and whole grains.

2. Stay Active

Regular physical activity not only helps manage weight but also can improve mood and reduce symptoms of depression and anxiety. Aim for at least 150 minutes of moderate-intensity exercise per week.

3. Stay Hydrated

Drinking adequate water can help control appetite and support overall health. Aim for at least 8 glasses of water per day.

4. Get Sufficient Sleep

Poor sleep can affect appetite hormones and lead to weight gain. Strive for 7-9 hours of quality sleep each night.

5. Communicate with Your Healthcare Provider

If you experience significant weight changes while taking Effexor, discuss your concerns with your doctor. They may adjust your dosage or consider alternative treatments if necessary.

Potential Side Effects of Effexor

While Effexor may not commonly cause significant weight gain, it’s important to be aware of other potential side effects. Some individuals may experience:

• Nausea or vomiting
• Dry mouth
• Dizziness or lightheadedness
• Insomnia or changes in sleep patterns
• Sexual dysfunction
• Increased sweating
• Headaches
• Constipation

Most side effects are typically mild and may subside as your body adjusts to the medication. However, if you experience persistent or severe side effects, consult your healthcare provider promptly.

Alternatives to Effexor for Weight-Conscious Patients

If weight gain is a significant concern, there are alternative antidepressants that may have a lower risk of weight-related side effects. Some options include:

• Bupropion (Wellbutrin): Often associated with weight loss
• Fluoxetine (Prozac): Generally weight-neutral or may cause slight weight loss
• Sertraline (Zoloft): Typically weight-neutral in most patients

It’s crucial to remember that the effectiveness of antidepressants can vary from person to person. The choice of medication should be based on individual needs, medical history, and the specific symptoms being treated. Always consult with a healthcare professional before making any changes to your medication regimen.

The Importance of Balanced Treatment for Mental Health

While managing potential side effects like weight changes is important, it’s equally crucial to prioritize effective treatment for depression and anxiety. Untreated mental health conditions can have significant impacts on overall health and quality of life. When considering treatment options, it’s essential to weigh the potential benefits against possible side effects.

Complementary Approaches to Mental Health Treatment

In addition to medication, consider incorporating other evidence-based approaches to support mental health:

• Psychotherapy (e.g., cognitive-behavioral therapy)
• Mindfulness and meditation practices
• Regular exercise
• Stress reduction techniques
• Social support and community engagement

A comprehensive approach that combines medication with lifestyle changes and therapeutic interventions often yields the best results in managing depression and anxiety.

Monitoring and Adjusting Treatment

Effective mental health treatment is an ongoing process that may require adjustments over time. Regular check-ins with your healthcare provider are essential to monitor your progress and address any concerns, including weight changes or other side effects.

Questions to Discuss with Your Doctor

• How is my current treatment affecting my symptoms?
• Are there any concerning changes in my weight or appetite?
• Should we consider adjusting my medication dosage?
• Are there alternative treatments that might be more suitable for my needs?
• What lifestyle changes can I make to support my mental health and manage side effects?

Open communication with your healthcare provider ensures that your treatment plan remains tailored to your individual needs and goals.

In conclusion, while Effexor is not typically associated with significant weight gain, individual responses to the medication can vary. By staying informed, monitoring your health, and working closely with your healthcare provider, you can effectively manage your mental health while minimizing unwanted side effects. Remember, the goal of treatment is to improve your overall well-being and quality of life, and finding the right balance may take time and patience.

Does Effexor® Cause Weight Gain?

If you’ve been diagnosed with major depressive disorder (MDD), generalized anxiety disorder (GAD), social anxiety disorder (SAD) or panic disorder (PD), your mental health provider may prescribe the medication Effexor XR® to help you manage your symptoms.

Effexor is an antidepressant. Like many other antidepressants, it can potentially cause some side effects. However, unlike with most medications for depression, reports of Effexor weight gain aren’t very common. 

In fact, some scientific research suggests that Effexor is more likely to contribute to mild weight loss than noticeable weight gain. 

Below, we’ve explained what Effexor is, as well as how it works as a medication for depression and anxiety. We’ve also discussed whether Effexor can cause weight gain, appetite changes or other changes in your eating habits. 

Finally, we’ve talked about what you can do to maintain a healthy weight while using Effexor or similar medication to treat major depression or anxiety

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What Is Effexor?

Effexor, which contained the active ingredient venlafaxine, was an antidepressant used to treat depression and anxiety disorders, including generalized anxiety disorder, social anxiety disorder and panic disorder. 

The Food and Drug Administration (FDA) first approved Effexor in 1993. Although the original medication is no longer available in the United States, venlafaxine is still sold as a generic drug and in extended-release form as Effexor XR®.

Venlafaxine, the active ingredient in Effexor, belongs to a class of antidepressants referred to as serotonin-norepinephrine reuptake inhibitors, or SNRIs. Like other antidepressants, it works by changing the levels of certain natural chemicals, called neurotransmitters, in your brain.

More specifically, venlafaxine works by increasing levels of the neurotransmitters serotonin and norepinephrine.

As a neurotransmitter, serotonin plays an important role in regulating your moods, your feelings of happiness and your levels of anxiety. It also helps manage your sleep cycle by stimulating the parts of your brain that cause you to feel tired at night and alert in the morning.

Normal serotonin levels are associated with a stable mental state. However, low serotonin levels are linked to an elevated risk of depression, anxiety, obsessive-compulsive disorder and suicidal thoughts and/or behavior.

Norepinephrine, or noradrenaline, is responsible for increasing your attention and focus, helping you form memories and recall information, and managing your sleep-wake cycle and general level of mental alertness throughout the day.

It also plays a key role in promoting proper cardiovascular function by increasing your heart rate and blood pressure when your body needs more energy.

Low levels of norepinephrine are associated with many signs of depression in women, including feelings of tiredness and lethargy, difficulty focusing and a reduced overall mood. Many people with low norepinephrine levels also suffer from other mental health issues, such as anxiety.

Experts believe that by increasing your levels of serotonin and norepinephrine, Effexor XR and generic venlafaxine can reduce the severity of many symptoms of depression and anxiety.

Like several other antidepressants, venlafaxine is also used off-label to treat medical conditions other than those for which it’s approved by the FDA. These include hot flashes, several forms of chronic pain and premenstrual dysphoric disorder (PMDD).

Does Effexor Cause Weight Gain?

If you’ve ever looked into the common side effects of antidepressants, you’ve most likely seen weight gain somewhere on the list.

It’s no secret that many antidepressants are associated with some degree of weight gain, often a significant amount. However, this issue is generally more common with older antidepressants than with newer medications such as Effexor XR®. 

Several different types of antidepressants are available, each with their own risk of certain side effects. Common types of antidepressants include:

• Selective serotonin reuptake inhibitors (SSRIs). These popular antidepressants work by increasing serotonin levels. They’re modern drugs that are generally used as first-line treatments for depression.

• Serotonin-norepinephrine reuptake inhibitors (SNRIs). These antidepressants work by increasing serotonin and norepinephrine levels. Like SSRIs, they’re newer, modern medications that are often used as first-line treatments for depression.

• Tricyclic antidepressants (TCAs). Tricyclic antidepressants are older medications that first came onto the market in the 1950s. Due to their significant risk of side effects, most tricyclic antidepressants aren’t used as first-line depression treatments today.

• Monoamine oxidase inhibitors (MAOIs). MAOIs are another older class of drugs from the 1950s and, like TCAs, they can cause side effects and drug interactions and aren’t used as first-line treatments for depression today.

• Other antidepressants. Some antidepressants, such as bupropion XL, don’t always fit into an obvious category. These drugs are sometimes called “atypical” antidepressants due to their unique mechanism of action and effects.  

Our full guide to depression medications provides more information on how these medications work, as well as their key differences. 

The risk of weight gain varies hugely between different antidepressant drugs, with some more associated with weight gain than others.

For example, in one review and meta-analysis published in the Journal of Clinical Psychiatry in 2010, researchers found that the antidepressants amitriptyline, mirtazapine, and paroxetine all had a significant association with weight gain, whereas other medications did not.

In general, clinical studies don’t suggest that Effexor XR or generic venlafaxine are associated with significant weight gain.

For example, one large-scale, population-based study looked at the effects of several common antidepressant medications on weight, including venlafaxine.

Although the number of participants that used venlafaxine was small, there was little long-term change in weight observed. In fact, the researchers estimated that venlafaxine may contribute to a small amount of weight loss with long-term use.

Large-scale clinical trials of venlafaxine, which took place prior to its approval by the FDA, also failed to show any evidence of significant weight gain. Instead, most young people prescribed venlafaxine lost a small amount of weight (approximately one pound over eight weeks).

With this said, a small amount of research has found that venlafaxine may cause weight gain in some people. For example, a study published in the journal General Hospital Psychiatry in 2015 found a link between several antidepressants and weight gain, one of which was venlafaxine.

Overall, the link between Effexor XR, generic venlafaxine and weight gain isn’t very clear, with a mix of studies showing either weight gain, mild weight loss or no significant changes in average body weight.  

This could mean that Effexor XR or generic venlafaxine are treatment options worth considering if you’re concerned about weight gain from other antidepressants.

Other Side Effects of Effexor

Although weight gain from Effexor XR is not common, Effexor XR and generic venlafaxine still have the potential to cause side effects.

Common adverse effects of Effexor XR and venlafaxine include:

Effexor XR and generic venlafaxine can also cause sexual side effects, including a reduction in your sex drive, difficulty achieving orgasm and other forms of sexual dysfunction. 

Men who use Effexor XR or generic venlafaxine may experience sexual function issues such as erectile dysfunction (ED) and abnormal ejaculation.

Other potential side effects of Effexor XR and generic venlafaxine include headache, dizziness, weakness, nightmares, vomiting, diarrhea, heartburn, stomach pain, a change in your ability to taste food, loss of appetite, shaking, numbness or tingling and hot flashes or flushing.

Some people who use Effexor XR or generic venlafaxine also experience urination issues, such as frequent urination or difficulty urinating.

In rare cases, Effexor XR and generic venlafaxine may cause more severe adverse reactions or signs of an allergic reaction.

Contact your healthcare provider as soon as possible if you experience difficulty with breathing or swallowing, rash, hives, itchy skin, a fast or irregular heartbeat, chest pain, unusual bleeding or bruising, fever, sweating, blurred vision or seizures.

It’s also important to seek immediate medical help if you experience confusion, changes in your coordination, hallucinations or coma.

Like other antidepressants, venlafaxine may interact with other medications. When it’s used with other medications that increase serotonin levels, Effexor XR or venlafaxine may contribute to an increased risk of serotonin syndrome — a potentially serious side effect.

To avoid drug interactions while using Effexor XR or generic venlafaxine, make sure to tell your healthcare provider about all medications you currently use or have recently used, including all medications you’ve taken within the last 14 days.  

It’s also important to closely follow your healthcare provider’s instructions and only use Effexor XR or generic venlafaxine at the prescribed daily dose.

While these side effects may sound alarming, it’s important to keep in mind that the majority of people who use venlafaxine do so safely without any issues. 

How to Maintain Your Weight While Using Effexor

Because Effexor generally doesn’t have as much of an effect on your eating habits or weight as other antidepressants, it shouldn’t be too difficult to maintain your normal body composition and weight while you’re using this medication.

Use the following tips to keep yourself healthy and maintain a steady weight while using Effexor XR or generic venlafaxine to treat psychiatric disorders such as depression or anxiety:

• Eat a balanced, healthy diet. Many common nutrients in food, including fatty acids and proteins, can have an effect on your brain health and function. Research even suggests that many people with depression have poor eating habits.
  Try to eat a healthy, balanced diet while you’re taking Effexor XR. Not only will this help you to maintain a consistent weight, but it may also improve your mood and assist you to recover from depression.

• Keep yourself physically active. Exercise not only burns calories and helps to prevent weight gain — it also promotes an increase in endorphin production and changes in brain function that can make you feel better.
  Try to keep yourself physically active, even if this just means going for a short walk every other day. Even a small amount of physical activity can have a big impact on your mental and physical well-being.

• Avoid undereating. Although antidepressants are usually associated with an increased food intake and some degree of weight gain, it’s also possible to eat too little while you’re taking part in treatment for depression.
  If you notice your weight starting to drop while taking Effexor XR or generic venlafaxine, try to increase your food intake until you’re able to comfortably maintain your usual body weight. And, of course, speak to your healthcare provider.

• Don’t use weight loss supplements with Effexor XR. It’s important not to use weight loss agents with Effexor XR or generic venlafaxine. These supplements may cause side effects and increase your risk of experiencing safety issues.

• Talk to your healthcare provider if you notice significant weight loss. According to clinical trials, just under 10 percent of people who use Effexor XR develop some degree of anorexia, an eating disorder characterized by not eating enough food.
  If you suddenly no longer feel like eating, or feel like you should deliberately avoid food or exercise excessively, it’s important to get help as soon as possible by reaching out to your mental health provider for medical advice. 

Does Effexor Cause Weight Loss?

So Effexor doesn’t cause weight issues, then? Not exactly. In fact, Effexor has been found to be responsible for the opposite problem: it can cause unexpected or unnecessary weight loss.

How much weight loss is another question entirely. Clinical studies haven’t firmed up a number or percentage, and even in the last few years, the work done on antidepressant-related weight loss hasn’t really included enough venlafaxine users to arrive at any conclusions.

It’s entirely possible that one person could lose ten ounces and another ten percent of their body weight, but most of the study data suggests the amount might be negligible.

Perhaps a better question to consider is whether Effexor weight loss matters.

Look, we get that in the real world, there are many women (and men) who aren’t happy with their bodies, with their weight or with their health. So an antidepressant that can simultaneously lead to weight loss sounds great in theory, doesn’t it? 

The problem, however, is that uncontrolled medication-induced weight loss is rarely healthy. And in addition to the side effects noted above, Effexor can be particularly dangerous for people who already have trouble keeping weight on, as well as for children who are still growing. In fact, it’s recommended that children avoid taking Effexor, since it can stunt growth.

And that’s not the only warning. In fact, there are warnings for people who are currently using weight loss drugs to avoid taking venlafaxine, and vice versa, as this drug combination may result in excessive weight loss, serotonin syndrome or cardiovascular problems like high blood pressure.

For a patient dealing with obesity or other weight gain issues, this medication may offer an unexpected benefit. But abusing that benefit or selecting this medication for that perceived beneficial outcome is… dumb.

Should You Avoid Effexor?

Effexor isn’t necessarily a medication you should avoid or not avoid. If a healthcare provider is concerned with you being underweight, for instance, they may advise you to use something else. Or, a healthcare professional might prescribe you a different medication if your quality of life is negatively affected by Effexor side effects. But in other cases, Effexor might be the right antidepressant for you.

The reality is that treating depression is complicated, and as much as we’d like to give you a clear answer on whether or not you should take Effexor, you need to consider the larger, holistic portrait of your mental health — the stuff beyond pills.

Mental health medications are most effective when used in combination with other forms of treatment, like therapy. Well-known versions of therapy these days don’t look like the couch-and-Freud stuff you see on TV. In fact, cognitive behavioral therapy (CBT) — the most effective kind of therapy for many people with depression — is more like a training strategy for your brain than a feelings exploration. 

CBT helps you learn to isolate depressive thoughts and ways of thinking and reprogram them over time. Medication may give you the chemical supply to be happy, but therapy is how you get your brain to start being happy.

And back to weight, the elephant in the room when it comes to depressive symptoms might be the effects of some of your lifestyle habits, like dietary choices, exercise, drug and alcohol use, tobacco use and social activity.

Effexor and Your Weight: The Big Picture

Let’s talk about the big picture for a moment: is your depression medication really the way you want to solve ongoing issues with your weight? Is a side effect of a mood stabilizer really the solution to weight problems? Do you even need to lose weight? 

Questions like these are designed to make you think, but truth be told, you might not be able to answer them alone. Problems with your mental health and your weight can’t be diagnosed, addressed or resolved on your own. To do that, you need the support of a healthcare professional.

Healthcare professionals are there to help you consider the symptoms of depressive disorders and figure out if you may actually have one. From there, they can help you determine the right way to handle treatment. 

The same goes for weight issues. These are professional concerns, and while you can easily improve your diet and exercise habits without medical care, medication is where the line has to be drawn. So get help from the right people. 

Trying to do just that? Consider using our mental health resources guide to learn more about various mental illness symptoms, symptoms of depression and what treatments are out there. You can also learn about other types of antidepressant drugs like tricyclic antidepressants and selective serotonin reuptake inhibitors, as well as other medications designed to treat mental health conditions like panic disorder, generalized anxiety disorder, social anxiety disorder and bipolar disorder.

But if you’re ready to take the next step in solving the problem, consider clicking a different link — one toonline therapy.

Whether it’s physical or mental health, professionals are ready to help you with your worries. All you have to do is reach out.

Learn More About Treating Depression

Effexor XR, which contains the active ingredient venlafaxine, is one of several medications used as an effective treatment for the symptoms of anxiety and depression.  

In general, the link between Effexor XR and weight gain isn’t clear. Some studies suggest that it may contribute to weight gain, while others suggest that it may cause weight loss or don’t show any significant changes in weight. 

You can maintain a stable weight while using Effexor XR or generic venlafaxine by following the tips above. If you notice your weight changing while using this medication, it’s best to reach out to your healthcare provider for assistance. 

We provide venlafaxine and other antidepressants online as part of our range of depression and anxiety medications, following a private consultation with a licensed healthcare provider who will determine if a prescription is appropriate.

We also offer a full range of online mental health services, including online therapy and support groups to help you deal with depression, anxiety, stress and other mental health conditions and concerns. 

Interested in learning more about managing depression? Our guide to the best medications for depression goes into more detail about your treatment options, from SNRIs such as Effexor XR to other medications for lifting your mood and providing relief from your symptoms.  

14 Sources

Hims & Hers has strict sourcing guidelines to ensure our content is accurate and current. We rely on peer-reviewed studies, academic research institutions, and medical associations. We strive to use primary sources and refrain from using tertiary references.

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2. [email protected]: FDA-Approved Drugs. (n.d.). Retrieved from https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=020151
3. Venlafaxine. (2022, January 15). Retrieved from https://medlineplus.gov/druginfo/meds/a694020.html
4. Brain Hormones. (2022, January 23). Retrieved from https://www.endocrine.org/patient-engagement/endocrine-library/hormones-and-endocrine-function/brain-hormones
5. Adrenal Hormones. (2022, January 23). Retrieved from https://www.endocrine.org/patient-engagement/endocrine-library/hormones-and-endocrine-function/adrenal-hormones
6. Singh, D. & Saadabadi, A. (2021, October 21). Venlafaxine. StatPearls. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK535363/
7. Sheffler, Z.M. & Abdijadid, S. (2021, November 14). Antidepressants. StatPearls. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK538182/
8. Moraczewski, J. & Aedma, K.K. (2021, November 30). Tricyclic Antidepressants. StatPearls. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK557791/
9. Sub Laban, T. & Saadabadi, A. (2021, August 6). Monoamine Oxidase Inhibitors (MAOI). StatPearls. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK539848/
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11. Arterburn, D., et al. (2016, April). Long-Term Weight Change after Initiating Second-Generation Antidepressants. Journal of Clinical Medicine. 5 (4), 48. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850471/
12. Uguz, F., et al. (2015). Weight gain and associated factors in patients using newer antidepressant drugs. General Hospital Psychiatry. 37 (1), 46-48. Retrieved from https://pubmed.ncbi.nlm.nih.gov/25467076/
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Side Effects and What to Do About Them

Effexor XR (venlafaxine) is a prescription drug that’s used to treat certain mental health conditions, such as major depressive disorder. Effexor XR can cause side effects that range from mild to serious. Examples include weight changes, sweating, and high blood pressure.

Effexor XR is used in adults to treat:

• major depressive disorder (commonly called depression)
• generalized anxiety disorder
• social anxiety disorder
• panic disorder

The active ingredient in Effexor XR is venlafaxine. (An active ingredient is what makes a drug work.) The drug comes as an extended-release (XR) capsule, which means it slowly releases the active ingredient over a prolonged period of time.

Keep reading to learn about the common, mild, and serious side effects that Effexor XR can cause. For a general overview of the drug, including details about its uses, see this article.

Some people may experience mild or serious side effects during their Effexor XR treatment. Examples of Effexor XR’s commonly reported side effects include:

• nausea
• feeling tired
• sweating*
• constipation
• sexual side effects

* To learn more about this side effect, see “Side effects explained” below.

Effexor XR may cause mild side effects in some people. Examples of mild side effects that have been reported with Effexor XR include:

• nausea
• feeling tired
• sweating*
• constipation
• dry mouth
• unusual dreams
• loss of appetite
• headache
• weight gain or weight loss*

* To learn more about this side effect, see “Side effects explained” below.

In most cases, these side effects should be temporary. And some may be easily managed, too. But if you have any symptoms that are ongoing or that bother you, talk with your doctor or pharmacist. And do not stop using Effexor XR unless your doctor recommends it.

Effexor XR may cause mild side effects other than the ones listed above. See the Effexor XR prescribing information for details.

Note: After the Food and Drug Administration (FDA) approves a drug, it tracks side effects of the medication. If you’d like to notify the FDA about a side effect you’ve had with Effexor XR, visit MedWatch.

In rare cases, some people may develop serious side effects from taking Effexor XR. Serious side effects that have been reported with Effexor XR include:

• suicidal thoughts or behaviors*
• serotonin syndrome (high level of the chemical serotonin)
• sexual side effects, such as erectile dysfunction and irregular ejaculation
• high blood pressure†
• unusual bleeding
• eye problems, such as closed-angle glaucoma
• mania or hypomania (both of which cause moments of extremely high excitement and energy)
• allergic reaction†‡
• low sodium in your blood
• seizures
• lung problems, such as pneumonia
• high cholesterol

If you develop serious side effects while taking Effexor XR, call your doctor right away. If the side effects seem life threatening or if you think you’re having a medical emergency, immediately call 911 or your local emergency number.

* Effexor XR has a boxed warning for this side effect. This is the most serious warning from the Food and Drug Administration (FDA). To learn more, see the “Side effects explained” section below.
† To learn more about this side effect, see “Side effects explained” below.
‡ An allergic reaction is possible after using Effexor XR. But it’s not clear whether this side effect occurred in studies.

You may experience more side effects in your first week of treatment with Effexor XR. But not everyone will experience side effects, and side effects can be different for each person.

You may be more likely to experience suicidal thoughts and behaviors* during the first week of treatment. If you notice symptoms, be sure to talk with your doctor.

When you first start taking a new medication, your body has to get used to it. So in the first week, you may experience more side effects. It takes about 3 days for Effexor XR to reach a consistent level in your blood. During the time that your body is adjusting, you may have a higher risk for side effects.

Side effects that you experience may also depend on other medical conditions you have or other medications you take. If you have questions about what to expect when you first start taking Effexor XR, talk with your doctor or pharmacist.

* Effexor XR has a boxed warning for this side effect. This is the most serious warning from the Food and Drug Administration (FDA). To learn more, see the “Side effects explained” section below.

Get answers to some frequently asked questions about Effexor XR’s side effects.

Are there any long-term side effects of Effexor XR?

Yes, long-term side effects of Effexor XR are possible. Examples include weight gain, weight loss, and eye problems such as closed-angle glaucoma.

It’s possible that taking Effexor XR for a longer period of time may raise your risk for long-term side effects. But this isn’t the case for everyone, as side effects of Effexor XR can vary from person to person.

If you’re concerned about long-term side effects of Effexor XR, talk with your doctor or pharmacist.

Do side effects from Effexor XR vary depending on the strength I take (37.5 mg, 75 mg, or 150 mg)?

It’s possible. You may have an increased risk for side effects if you’re taking a higher dose of Effexor XR. This is because there’s more medication in your body, and it may have a greater effect on you.

Effexor XR is available in strengths of 37.5 milligrams (mg), 75 mg, and 150 mg. In most cases, the maximum recommended dose of Effexor XR is 225 mg per day. In some cases, doctors may prescribe a dose as high as 300 mg per day. But this is not an FDA-approved dose.

You should always take the dosage your doctor prescribes for you. They’ll determine the best dosage to fit your needs.

If you’re experiencing side effects from Effexor XR, talk with your doctor. They may want to lower your dose to see if this helps reduce your side effects.

Will Effexor XR cause withdrawal symptoms if I stop taking it?

Effexor XR can cause withdrawal symptoms if treatment stops suddenly.

Examples of withdrawal symptoms that may occur if you stop taking Effexor XR include:

• agitation or irritability
• confusion
• dizziness
• anxiety
• headache
• insomnia (trouble sleeping)
• seizures

If you’re interested in stopping your Effexor XR treatment, talk with your doctor first. They’ll likely want to decrease your dose slowly to help reduce the risk of withdrawal symptoms.

In most cases, your doctor will decrease your dose by 75 milligrams per week until you’re not taking the drug anymore. But be sure to follow your doctor’s recommendation for decreasing your dose and stopping treatment.

Because some withdrawal symptoms may be serious, you should not stop taking Effexor XR without first talking with your doctor. They can help you safely stop your treatment.

Can side effects occur if I miss a dose of Effexor XR?

Yes, it’s possible that missing a dose of Effexor XR may cause certain side effects, including withdrawal symptoms.

If you miss a dose of Effexor XR, take it as soon as you remember. But if it’s almost time for your next dose, skip your missed dose and take your next dose on your regular schedule. You should not take two doses of Effexor XR to make up for a missed dose. Doing so could raise your risk for side effects.

How long do side effects from Effexor XR last?

It depends. Some side effects, such as nausea, may occur when you first start taking Effexor XR but may go away after you take it for a while. Other side effects, including decreased appetite and changes in weight, may last throughout your treatment.

If you’re concerned about certain side effects of Effexor XR, talk with your doctor. They can discuss your risk for these side effects and how long they may last if you do experience them. Your doctor may also be able to treat your side effects so they don’t last as long.

Learn more about some of the side effects Effexor XR may cause.

Weight gain or weight loss

Weight gain or weight loss can occur in people taking Effexor XR. But these were not common side effects reported in studies of Effexor XR.

What might help

If you’re concerned about any unexpected weight gain or weight loss you experience while taking Effexor XR, talk with your doctor. They can help determine what your next steps should be.

Sweating

You may experience sweating during your Effexor XR treatment. Sweating was one of the most common side effects that people taking Effexor XR reported in studies.

What might help

If you’re sweating more than usual while taking Effexor XR and it’s bothersome to you, talk with your doctor. They may be able to recommend ways to decrease this side effect. In some cases, they may recommend a different medication to treat your mental health condition.

Suicidal thoughts and behaviors in children and young adults

Effexor XR has a boxed warning for the risk of suicidal thoughts and behaviors in children and in young adults (ages 18 to 24 years). A boxed warning is the most serious warning from the Food and Drug Administration (FDA). It alerts doctors and patients about drug effects that may be dangerous.

All antidepressant drugs carry this boxed warning about suicidal thoughts and behaviors. These side effects can occur within the first few months of starting treatment or whenever the dose is increased or decreased.

It’s important to note that Effexor XR is not approved for anyone younger than 18 years old.

What might help

It’s important that you tell your doctor if you notice any new or worsening symptoms of depression or suicidal thoughts or behavior. These may include:

• suicidal thoughts or suicide attempts
• violence or aggression
• anxiety or panic attacks
• feeling restless or irritable
• insomnia (trouble sleeping)
• changes in behavior or mood

If you notice any of these symptoms, talk with your doctor. If the side effects seem life threatening or if you think you’re having a medical emergency, immediately call 911 or your local emergency number.

If you’re a young adult taking Effexor XR, your doctor will likely monitor you more closely during treatment for any symptoms of depression and suicidal thoughts or behaviors.

Help is out there

If you or someone you know is in crisis and considering suicide or self-harm, please seek support:

• Call the 988 Suicide and Crisis Lifeline at 988.
• Text HOME to the Crisis Textline at 741741.
• Not in the United States? Find a helpline in your country with Befrienders Worldwide.
• Call 911 or your local emergency services number if you feel safe to do so.

If you’re calling on behalf of someone else, stay with them until help arrives. You may remove weapons or substances that can cause harm if you can do so safely.

If you are not in the same household, stay on the phone with them until help arrives.

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High blood pressure

Effexor may increase your blood pressure. In studies, some people who didn’t already have high blood pressure developed the condition after starting treatment with Effexor XR.

If you already have high blood pressure, Effexor XR may make it worse.

What might help

Before you start taking Effexor XR, tell your doctor about any blood pressure concerns you have or if you’re taking medication to lower your blood pressure.

If you have untreated high blood pressure, your doctor will likely want to treat it before starting your Effexor XR treatment. This is because the drug can also increase your blood pressure, which may be unsafe if your blood pressure is already high.

Your doctor will also check and monitor your blood pressure throughout your treatment.

Allergic reaction

Like most drugs, Effexor XR can cause an allergic reaction in some people. But it’s not clear whether this side effect occurred in studies.

Symptoms can be mild or serious and can include:

• skin rash
• itchiness
• flushing (temporary warmth, redness, or deepening of skin color)
• swelling under your skin, typically in your eyelids, lips, hands, or feet
• swelling of your mouth, tongue, or throat, which can make it hard to breathe

Allergic reactions can also affect the eyes. It’s important that you tell your doctor if you notice any problems with your eyes. Symptoms may include:

• changes in your vision
• eye pain
• redness, discoloration, or swelling in or around your eye

What might help

If you have mild symptoms of an allergic reaction, such as a mild rash, call your doctor right away. They may suggest an over-the-counter antihistamine that you swallow, such as Benadryl (diphenhydramine), or a product that you apply to your skin, such as hydrocortisone cream, to manage your symptoms.

If your doctor confirms you had a mild allergic reaction to Effexor XR, they’ll decide if you should continue using it.

If you have symptoms of a severe allergic reaction, such as swelling or trouble breathing, call 911 or your local emergency number right away. These symptoms could be life threatening and require immediate medical care.

If your doctor confirms you had a serious allergic reaction to Effexor XR, they may have you switch to a different treatment.

Keeping track of side effects

During your Effexor XR treatment, consider keeping notes on any side effects you’re having. Then, you can share this information with your doctor. This is especially helpful to do when you first start taking new drugs or using a combination of treatments.

Your side effect notes can include things such as:

• what dose of drug you were taking when you had the side effect
• how soon after starting that dose you had the side effect
• what your symptoms were from the side effect
• how it affected your daily activities
• what other medications you were also taking
• any other information you feel is important

Keeping notes and sharing them with your doctor will help your doctor learn more about how the drug affects you. Your doctor can use this information to adjust your treatment plan if needed.

Before you start taking Effexor XR, talk with your doctor about any medical conditions you have or any medications you take. They can determine if this medication may be a safe treatment option for you.

Details about this drug’s warnings are below.

Boxed warning: Suicidal thoughts and behaviors in children and young adults

Effexor XR has a boxed warning for suicidal thoughts and behaviors in children and in young adults (ages 18 to 24 years). A boxed warning is the most serious warning from the Food and Drug Administration (FDA). It alerts doctors and patients about drug effects that may be dangerous.

If you’re a young adult taking Effexor XR, your doctor will likely monitor you more closely during treatment for any symptoms of depression and suicidal thoughts or behaviors.

It’s important to note that Effexor XR is not approved for anyone younger than 18 years old.

To learn more, see the “Side effects explained” section above.

Other warnings

Effexor XR may not be right for you if you have certain medical conditions or other factors that affect your health. Talk with your doctor about your health history before you take Effexor XR. The list below includes factors to consider.

High blood pressure or other heart problems. Before taking Effexor XR, tell your doctor if you have high blood pressure. This drug may cause your blood pressure to increase even more. Your doctor will check your blood pressure before you start treatment. If it’s not well managed, your doctor will likely recommend treating your high blood pressure before you start taking Effexor XR. Even if your blood pressure is well managed, your doctor may want to monitor you more closely during your Effexor XR treatment. This is to make sure your blood pressure doesn’t get too high.

Allergic reaction. If you’ve had an allergic reaction to Effexor XR or any of its ingredients, you should not take Effexor XR. Ask your doctor what other medications are better options for you.

Bipolar disorder or mania. Effexor XR may make your symptoms of bipolar disorder or mania worse. If you have one of these conditions, your doctor may recommend a different medication to treat your condition, or they may monitor you more closely during your treatment.

Glaucoma. Effexor XR may cause an eye condition called closed-angle glaucoma. If you already have closed-angle glaucoma, Effexor XR may make your condition worse. Before taking Effexor XR, talk with your doctor about any eye conditions you have.

Liver problems. Effexor XR may cause elevated liver enzymes, which may be a sign of a liver condition. If you already have a liver problem, Effexor XR may make your condition worse. Before you start treatment with Effexor XR, tell your doctor about any liver conditions you have.

Kidney problems. Effexor XR is removed from your body through your kidneys. If your kidneys aren’t working properly, your body may not be able to get rid of the drug as quickly as it should. This can cause levels of the drug to build up in your body, which can raise your risk for side effects. If you have any kidney problems, talk with your doctor before taking Effexor XR. They can determine if this drug is safe for you to take.

Seizures or convulsions. Effexor XR may raise your risk for seizures. If you have a seizure condition or have had seizures or convulsions before, Effexor XR may raise your risk for seizures even more. Talk with your doctor about whether Effexor XR is safe for you to take.

Low sodium in your blood. Effexor XR can decrease the amount of sodium in your blood. If you already have low sodium levels, this can be dangerous. Low sodium levels can cause confusion, fatigue, seizures, and even coma. If you have low sodium levels in your blood or have had this condition before, tell your doctor before taking Effexor XR.

High cholesterol. Effexor XR may cause your cholesterol levels to increase. If you already have high cholesterol, this drug can make it worse. Talk with your doctor to see if this drug is right for you.

Bleeding problems. Effexor XR may raise your risk for bleeding. If you have any conditions that could also cause bleeding problems, or if you’re taking medications that may affect your blood, tell your doctor before taking Effexor XR. They may recommend a different medication for you, or they may monitor you more closely throughout your treatment.

Alcohol and Effexor XR

You should not drink alcohol while taking Effexor XR. Alcohol may raise your risk for certain side effects from Effexor XR.

If you drink and have concerns about avoiding alcohol during your Effexor XR treatment, talk with your doctor.

Pregnancy and breastfeeding while taking Effexor XR

Below are details about using Effexor XR during pregnancy or while breastfeeding.

Pregnancy

It’s not known if Effexor XR is safe to take during pregnancy. If you’re pregnant or planning to become pregnant, talk with your doctor before taking Effexor XR.

Breastfeeding

Taking Effexor XR while breastfeeding is not recommended. Effexor XR passes into breast milk, and it may affect a child who is breastfed. If you’re currently breastfeeding or planning to breastfeed, talk with your doctor about your options.

Effexor XR may be an effective treatment for certain mental health conditions. But some people may experience side effects with this drug. Most side effects are mild, but some may be serious.

It’s important to discuss potential side effects with your doctor before taking Effexor XR so you know what to watch for. Here are some questions you may want to ask your doctor:

• How should I treat any side effects that I experience?
• Do I have a higher risk for side effects based on my other medical conditions?
• What should I do if I become pregnant while taking Effexor XR?

To get information on different conditions and tips for improving your health, subscribe to any of Healthline’s newsletters. You may also want to check out the online communities at Bezzy. It’s a place where people with certain conditions can find support and connect with others.

Q:

If I’m taking a monoamine oxidase inhibitor (MAOI), how long should I wait between stopping the MAOI and starting treatment with Effexor XR so that I don’t experience side effects?

Anonymous

A:

A: If you’re taking Effexor XR with an MAOI such as the antidepressant Nardil (phenelzine) or the antibiotic Zyvox (linezolid), you should not take these medications within 7 days of stopping Effexor XR unless your doctor recommends it. It’s also important that you stop taking an MAOI at least 2 weeks before starting your Effexor XR treatment.

Before you stop taking any medications, be sure to check with your doctor first.

The Healthline Pharmacist TeamAnswers represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.

Was this helpful?

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

Which antidepressants cause the greatest weight gain?

Medicines and vitamins

• Medical author: Dr. Shruti M., MBBS
• Medical Reviewer: Pallavi Suyog Uttekar, MD

• May cause weight gain
  • Antidepressants which may cause weight gain
• May cause weight gain
  • Antidepressants which may or may not cause weight gain
• Don’t Induce Weight Gain
  • Antidepressants that do not cause weight gain
• What to do
  • Dealing with unwanted weight gain from antidepressants
• What causes weight gain
  • Why do antidepressants cause weight gain?
• Other treatment options for depression
  • Are there other treatment options for depression?

Why do antidepressants cause weight gain? Find out which ones cause and do not cause weight gain

Although weight gain is a possible side effect of almost all antidepressants, everyone reacts differently to antidepressants. Some people may gain weight during treatment, while others may not.

Antidepressants that may increase anticipation include:

• Atypical antipsychotic medications (eg Risperdal, Ability and Zyprexa)
• Selective serotonin reuptake inhibitors (SSRIs) (such as Paxil, Remeron and Zoloft)

Both the likelihood of weight gain and the amount of possible weight gain vary from drug to drug. Appetite regulation and weight gain or loss are highly complex responses influenced by a wide range of hormones, all of which can be adversely affected by antidepressants. Some antidepressants are more likely to cause weight gain than others:

• TCAs and possibly MAOIs may be more likely to cause weight gain than SSRIs or newer antidepressants, with the exception of Remeron.
• SSRIs tend to cause early loss of appetite, sometimes due to side effects such as nausea, and others may cause weight gain with long-term use (eg Paxil).
• Some antidepressants, such as Effexor and Wellbutrin, may be less likely to cause weight gain.

Antidepressants that can cause weight gain

Monoamine oxidase inhibitors (MAOIs)

• MAOIs interfere with neurotransmitters that communicate between brain cells by preventing an enzyme called monoamine oxidase from removing the neurotransmitters norepinephrine, serotonin and dopamine from the brain. This allows these neurotransmitters to stay in the brain for a longer time, thereby boosting your mood.
• Weight gain is likely in the short (less than 6 months) and long term (1 year or more) term.
• Examples of MAOIs include Marplan (isocarboxazid), Nardil (phenelzine), and parnate (tranylcypromine).

Tricyclic compounds (TCAs)

• Tricyclic antidepressants (TCAs) help keep more serotonin and norepinephrine in the brain. These chemicals are naturally produced by your body and are thought to affect your mood.
• Weight gain is likely in both the short and long term.

SSRIs other than paroxetine

• SSRIs treat depression by increasing serotonin levels in the brain. Serotonin is one of the neurotransmitters that transmit signals between brain nerve cells. SSRIs block the reabsorption (reuptake) of serotonin by neurons.
• Weight gain is less likely in the short term. Long-term weight gain is possible, but evidence varies.
• Examples include Paxil, Zoloft, Celexa, and Prozac.

how much zoloft should I take

Antidepressants that may or may not cause weight gain

• paroxetine : Short and long term weight gain is more likely than other SSRIs.
• Nefazodone: Most likely this will not affect the weight.
• bupropion : This is likely to cause weight loss.
• Mirtazapine (an atypical antidepressant): Weight gain is likely in the short term but less likely than tricyclics.
• Venlafaxine : This will most likely not affect weight.

Antidepressants that do not cause weight gain

According to current scientific research, antidepressants are the least likely to cause weight gain:

• Effexor (venlafaxine)
• Wellbutrin (bupropion)
• Nefazodone (but rarely used because it can cause severe liver problems)

Dealing with unwanted weight gain from antidepressants

If you are experiencing unwanted weight gain due to antidepressants:

• Follow a healthy diet and regular exercise program to keep your weight under control.
• Talk to your doctor about switching to a different antidepressant if necessary.

Why do antidepressants cause weight gain?

According to a 2015 study, the weight gain that occurs with psychiatric medications is caused by changes at the cellular level, including hormonal changes and changes in the body. metabolism of glucose (sugar) as well as lipids (fats).

Antidepressants may have the following weight gain effects:

• Appetite stimulation (tricyclic antidepressants [TCAs]) with high mood
• Increased carbohydrate cravings (TCA)
• Interference with Central nervous system functions regulating energy balance
• Changes in resting metabolic rate (TCAs, selective serotonin reuptake inhibitors [SSRIs] and monoamine oxidase inhibitors [MAOIs])
• Genetic predisposition to weight gain
• Counteracting the action of 5-HT2 receptors (serotonin receptors), which then increase appetite
• Norepinephrine production disorder

Are there other treatment options for depression?

Whether antidepressants cause unwanted weight gain or not, it’s always good to have multiple treatment options.

• When it comes to treating your depression, a combination of medication, psychotherapy, and lifestyle changes may be the best approach.
• Cognitive behavioral therapy (CBT) is a common, effective, and evidence-based treatment option for depression.
• Transcranial Magnetic Stimulation (TMS) therapy is another great way to treat depression by completely avoiding the weight gain factor.

It is always recommended to discuss your treatment protocol with your doctor, especially when it comes to depression.

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References Weight gain and antidepressants: https://pubmed. ncbi.nlm.nih.gov/10926053/

Antidepressants and weight gain: https://womensmentalhealth.org/posts/antidepressants-and-weight-gain/

Antidepressant use and incidence of weight gain at 10 years follow-up: population cohort study: https://www.bmj.com/content/361/bmj.k1951

what they are and what effects they have

Psychiatrists usually recommend medication as the initial treatment to control symptoms as quickly as possible.

Once your symptoms are under control, you will receive supportive care to reduce your risk of relapse.

Supportive care also reduces the chance that minor mood changes turn into mania or depression.

Several types of medications are used to treat bipolar disorder.

These include mood stabilizers, antidepressants, and anxiety medications. Your doctor may prescribe one or a combination of medications for maximum effect.

Finding the right remedy or combination of remedies will require trial and error.

You may need to change your medications because of side effects.

Each drug may take up to eight weeks to see the full effect.

Usually only one drug is changed at a time.

This helps your doctor better monitor and determine which one is not working.

The following types of drugs are used to treat bipolar disorder

Lithium

Lithium (such as Lithobid) is a mood-stabilizing drug that has been used since the 1970s.

It helps control the symptoms of acute mania.

It is also effective in preventing the recurrence of periods of mania and depression.

Common side effects include weight gain and digestive problems.

The drug may also affect the thyroid and kidneys. Periodic blood tests are needed to monitor the condition of the thyroid gland and kidneys.

Lithium is a category D drug that should be avoided during pregnancy if possible.

However, in some cases the benefits may outweigh the potential risks.

Anticonvulsants

Anticonvulsants are mood stabilizers used to treat bipolar disorder.

They have been in use since the mid-1990s. A

Anticonvulsants include:

• sodium divalproex (Depakot)
• lamotrigine (lamiktal)
• valproic acid (Depaken)

Common side effects of anticonvulsants include weight gain, drowsiness, and inability to sit still.

Anticonvulsants are also associated with an increased risk of suicidal thoughts and behavior.

Valproic acid is known to cause birth defects.

Lamictal is known to cause a dangerous rash.

Tell your doctor about any new rash that develops while taking Lamictal.

Antipsychotics

Antipsychotics are another treatment option. Some commonly prescribed antipsychotics include:

• olanzapine (Zyprexa)
• risperidone (Risperdal)
• Quetiapine (Seroquel)
• lurasidone (Latuda)
• aripiprazole (Abilify)
• Azenapine (Saphris)

Common side effects include weight gain, drowsiness, dry mouth, decreased libido and blurred vision.

Antipsychotics may also affect memory and attention.

They are also known to cause involuntary movements of the face or body.

Antidepressants

These include serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), monoamine oxidase inhibitors (MAOIs), and tricyclics.

Antidepressants may be added to help manage depression in bipolar disorder, but they can sometimes cause manic episodes.

To reduce the risk of a mixed or manic episode, they are often given with mood stabilizers or antipsychotics.

As with any medication, talk to your doctor about the risks and benefits of taking antidepressants for bipolar disorder.

Some of the most commonly prescribed antidepressants are:

• SNRIs
• desvenlafaxine (Pristiq)
• duloxetine (Cymbalta, Yentreve)
• venlafaxine (Effexor)
• SSRIs
• citalopram (Celexa)
• escitalopram (Lexapro)
• fluoxetine (Prozac, weekly Prozac)
• paroxetine (Paxil, Paxil CR, Pekseva)
• sertraline (Zoloft)
• Tricyclics
• amitriptyline
• desipramine (Norpramine)
• imipramine (Tofranil, Tofranil-PM)
• nortriptyline (pamelor)
• IMAO
• phenelzine (nardil)
• tranylcypromine (parnate)

In general, MAOIs are rarely prescribed unless the patient has a poor response to SNRIs or SSRIs.

Common side effects include decreased sex drive, disturbed sleep, increased appetite, dry mouth, gastrointestinal disturbances, and menstrual problems.

While taking an MAOI, it is important to avoid other drugs and foods, such as wine and cheese, which can cause a rare but dangerous condition known as serotonin syndrome.

Benzodiazepines and Bipolar Disorder

This is a group of drugs that have sedative properties. Benzodiazepines include:

• alprazolam (Xanax)
• chlordiazepoxide (librium)
• clonazepam (Klonopin)
• diazepam (Valium)
• lorazepam (ativan)

Side effects may include drowsiness, decreased muscle coordination, and problems with balance and memory.

These drugs should be used with caution due to the risk of dependence.

Symbiax

This medication is a combination of fluoxetine and the antipsychotic olanzapine. Symbyax has both antidepressant and mood stabilizer properties.

Side effects may include increased appetite, sexual problems, drowsiness, fatigue, and dry mouth.

If your doctor prescribes this medicine, ask if separate prescriptions for the two ingredients are cheaper.

There is nothing special about the combination tablet. It’s just a new formulation of two existing drugs.

References:

• Bipolar disorder. (2016).
  nimh.nih.gov/health/topics/bipolar-disorder/index.shtml
• FDA pregnancy categories (2017).
  chemm.nlm.nih.gov/pregnancycategories.htm
• Mayo Clinic staff. (2017). serotonin syndrome.
  mayoclinic.org/diseases-conditions/serotonin syndrome/symptoms-causes/syc-20354758
• Mayo Clinic staff. (2018). Bipolar disorder.
  mayoclinic.org/diseases-conditions/bipolar disorder/symptoms-causes/syc-20355955

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