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Can i drink alcohol while taking cefdinir: Can You Take Antibiotics And Alcohol?

by alexxlab

Can You Take Antibiotics And Alcohol?

Taking antibiotics and drinking alcohol can be a risky combination, especially for those who consume alcohol frequently. Alcohol can interfere with the effectiveness of antibiotics, and both can cause adverse side effects. 

Before you reach for a glass of wine while on antibiotics, it is important to understand the risks of combining antibiotics and alcohol. 

In this blog, we will discuss the risks and side effects of drinking alcohol while taking antibiotics, as well as tips for avoiding alcohol while on antibiotics.

Key Takeaways

Antibiotics can help treat infections, but mixing them with alcohol can be dangerous. In this blog you will learn:

  • Alcohol can interfere with the effectiveness of antibiotics.
  • Alcohol can increase the risk of side effects of antibiotics, such as nausea or vomiting.
  • Mixing antibiotics and alcohol can cause liver damage.

If you struggle to abstain from alcohol, even when presented with a prescription for antibiotics, you may have an alcohol use disorder. Seek lasting help with Indiana Center for Recovery.

Antibiotics Explained

Antibiotics are medications used to treat bacterial infections. They work by either killing or stopping the growth of bacteria in your body. 

Antibiotics can be taken orally or injected, depending on the type of infection you have. Common antibiotics include penicillin, amoxicillin, cefdinir, doxycycline, and Bactrim.

Antibiotics and Alcohol: Understanding the Risks

Combining antibiotics and alcohol can be dangerous. Alcohol can interfere with the effectiveness of antibiotics and can lead to serious side effects. 

It is essential to understand the risks of combining antibiotics and alcohol before you decide to drink while on antibiotics.

The most common risk of drinking while taking antibiotics is that it can reduce the effectiveness of the antibiotic. 

Alcohol can prevent the antibiotic from entering your bloodstream, which can make it less effective. This can lead to a longer recovery time and an increased chance of the infection returning.

Another risk is that drinking alcohol can increase the side effects of certain antibiotics. Some antibiotics, such as doxycycline and metronidazole, can cause nausea and vomiting. Drinking alcohol while taking these antibiotics can make these side effects worse.

The risk of combining antibiotics and alcohol also depends on the type of antibiotic you are taking. Some antibiotics, such as penicillin, are not affected by alcohol. 

However, other antibiotics, such as Bactrim, can interact with alcohol and increase the risk of severe side effects.

How Different Types of Antibiotics Interact With Alcohol

There are many different types of antibiotics, and each one has a different interaction with alcohol. The most common antibiotics are penicillin, amoxicillin, cefdinir, doxycycline, and Bactrim.

  • Penicillin is one of the most commonly prescribed antibiotics, and it is not affected by alcohol. Therefore, you can safely drink alcohol while taking penicillin.
  • Amoxicillin is a type of penicillin and, like penicillin, it is not affected by alcohol. Therefore, you can drink alcohol while taking amoxicillin.
  • Cefdinir is an antibiotic used to treat bacterial infections, and it is not affected by alcohol. Therefore, you can safely drink alcohol while taking cefdinir.
  • Doxycycline is an antibiotic used to treat bacterial infections, and it can interact with alcohol. Drinking alcohol while taking doxycycline can increase the risk of nausea and vomiting.
  • Bactrim is an antibiotic used to treat bacterial infections, and it can interact with alcohol. Drinking alcohol while taking Bactrim can increase the risk of dizziness, drowsiness, and stomach upset.

How Alcohol Affects Antibiotics

Alcohol can affect the effectiveness of antibiotics. Alcohol can reduce the effectiveness of antibiotics, and it can also increase the risk of side effects. 

Therefore, it is important to understand the risks of combining antibiotics and alcohol before deciding to drink while on antibiotics.

Potential Side Effects of Mixing Alcohol and Antibiotics

The potential side effects of combining antibiotics and alcohol depend on the type of antibiotic you are taking. Some antibiotics, such as doxycycline and Bactrim, can interact with alcohol and increase the risk of side effects. 

Common side effects of mixing alcohol and antibiotics include dizziness, drowsiness, nausea, vomiting, and stomach upset.

It is important to note that drinking alcohol while taking antibiotics can also increase the risk of liver damage. Drinking alcohol while taking antibiotics can increase the levels of the antibiotic in your blood, which can cause liver damage. Therefore, it is essential to talk to your doctor before deciding to drink while on antibiotics.

Safe Practices for Antibiotic Use

It is essential to wait at least 72 hours after taking antibiotics before drinking alcohol. This is because antibiotics can remain in your system for up to 72 hours after taking them.  

Drinking alcohol while the antibiotic is still in your system can increase the risk of side effects and reduce the effectiveness of the antibiotic.

Tips for Avoiding Alcohol While Taking Antibiotics

If you are taking antibiotics and want to avoid drinking alcohol, there are some tips that can help.

First, it is essential to read the labels of your medications to make sure that alcohol is not listed as a potential side effect. If alcohol is listed as a potential side effect, it is best to avoid drinking while on antibiotics.

Second, it is essential to talk to your doctor about the potential risks of mixing alcohol and antibiotics. Your doctor can help you understand the risks of combining alcohol and antibiotics.

Third, it is important to drink plenty of fluids while taking antibiotics. This can help flush the antibiotic out of your system and reduce the risk of side effects.

Finally, it is important to avoid drinking alcohol while you are feeling ill. Drinking alcohol while you are feeling unwell can make the symptoms worse.

Antibiotics and Alcohol: In Summary

Combining antibiotics and alcohol can be risky. Alcohol can reduce the effectiveness of antibiotics and can also increase the risk of side effects. 

Therefore, it is important to understand the risks of combining antibiotics and alcohol before deciding to drink while on antibiotics. If you are struggling with alcohol addiction, reach out to Indiana Center For Recovery today for help.

By understanding the risks of combining antibiotics and alcohol, you can make an informed decision about whether or not to drink while on antibiotics. 

Frequently Asked Questions (FAQ)

Can you drink alcohol while taking antibiotics?

It is not recommended to drink alcohol while taking antibiotics. Alcohol can reduce the effectiveness of the antibiotic and can increase the risk of side effects. Therefore, it is essential to talk to your doctor before deciding to drink while on antibiotics.

Does alcohol affect antibiotics?

Yes, alcohol can affect the effectiveness of antibiotics. Alcohol can prevent the antibiotic from entering your bloodstream, which can make it less effective. Therefore, it is important to avoid drinking alcohol while taking antibiotics.

How long after taking antibiotics should you wait before drinking again?

It is essential to wait at least 72 hours after taking antibiotics before drinking alcohol. This is because antibiotics can remain in your system for up to 72 hours after taking them. Drinking alcohol while the antibiotic is still in your system can increase the risk of side effects and reduce the effectiveness of the antibiotic.

Are there any tips for avoiding alcohol while taking antibiotics?

Yes, there are some tips that can help you avoid drinking alcohol while taking antibiotics. First, it is important to read the labels of your medications to make sure that alcohol is not listed as a potential side effect.  
Second, it is important to talk to your doctor about the potential risks of mixing alcohol and antibiotics. Third, it is important to drink plenty of fluids while taking antibiotics. 
Finally, it is important to avoid drinking alcohol while you are feeling ill.

Indiana Center for Recovery Understands Addiction

If you find yourself unable to stop drinking, even while on antibiotics, it is time to get treatment.

Indiana Center for Recovery provides comprehensive and holistic treatment for those suffering from alcoholism. We provide alcohol detox in a safe and comfortable setting, as well as post-detox treatment, to minimize the risk of relapse.

We offer a wide range of treatment services, which include inpatient treatment, outpatient treatment, dual diagnosis, and evidence-based therapies.

Along with alcohol addiction, our medical professionals also treat addictions to other drugs, including benzos, meth, cocaine, opioids, suboxone, and many others.

Contact us today at (844) 650-0064 to get started on your recovery journey.

Fact versus Fiction: a Review of the Evidence behind Alcohol and Antibiotic Interactions

1. Lwanga J, Bingham JS, Bradbeer CS.
2008.
Do antibiotics and alcohol mix? The beliefs of genitourinary clinic attendees. Br Med J
337:a2885. doi: 10.1136/bmj.a2885. [CrossRef] [Google Scholar]

2. Kantor ED, Rehm CD, Haas JS, Chan AT, Giovannucci EL.
2015.
Trends in prescription drug use among adults in the United States from 1999–2012. JAMA
314:1818–1831. doi: 10.1001/jama.2015.13766. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

3. Centers for Disease Control and Prevention. 2016.
Outpatient antibiotic prescriptions—United States, 2016. Centers for Disease Control and Prevention, Atlanta, GA. [Google Scholar]

4. National Institute on Alcohol Abuse and Alcoholism. 2014.
Harmful interactions mixing alcohol with medicines. NIH publication no. 13-5329. National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD. [Google Scholar]

5. U.S. Food and Drug Administration. 2013.
Avoid food-drug interactions. U.S. Food and Drug Administration, White Oak, MD.

6. Weathermon R, Crabb DW.
1999.
Alcohol and medication interactions. Alcohol Res Health
23:40–54. [PMC free article] [PubMed] [Google Scholar]

7. Moore AA, Whiteman EJ, Ward KT.
2007.
Risks of combined alcohol-medication use in older adults. Am J Geriatr Pharmacother
5:64–74. doi: 10.1016/j.amjopharm.2007.03.006. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

8. Barth KS, Malcolm RJ.
2010.
Disulfiram: an old therapeutic with new applications. CNS Neurol Disord Drug Targets
9:5–12. doi: 10.2174/187152710790966678. [PubMed] [CrossRef] [Google Scholar]

9. Whittle J, Fine MJ, Joyce DZ, Lave JR, Young WW, Hough LJ, Kapoor WN.
1997.
Community-acquired pneumonia: can it be defined with claims data?
Am J Med Qual
12:187–193. doi: 10.1177/0885713X9701200404. [PubMed] [CrossRef] [Google Scholar]

10. Lindberg RL, Huupponen RK, Viljanen S, Pihlajamaki KK.
1987.
Ethanol and the absorption of oral penicillin in man. Int J Clin Pharmacol Ther Toxicol
25:536–538. [PubMed] [Google Scholar]

11. Morasso MI, Hip A, Marquez M, Gonzalez C, Arancibia A.
1988.
Amoxicillin kinetics and ethanol ingestion. Int J Clin Pharmacol Ther Toxicol
26:428–431. [PubMed] [Google Scholar]

12. Goodwani S, Rao PS, Bell RL, Sari Y.
2015.
Amoxicillin and amoxicillin/clavulanate reduce ethanol intake and increase GLT-1 expression as well as AKT phosphorylation in mesocorticolimbic regions. Brain Res
1622:397–408. doi: 10.1016/j.brainres.2015.07.008. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

13. Preheim LC, Olsen KM, Yue M, Snitily MU, Gentry MJ.
1999.
Ethanol feeding does not affect the efficacy or pharmacokinetics of azithromycin, trovafloxacin, or ceftriaxone in a rat model of pneumococcal pneumonia. Alcohol Clin Exp Res
23:842–849. doi: 10.1111/j.1530-0277.1999.tb04192.x. [PubMed] [CrossRef] [Google Scholar]

14. Barrio Lera JP, Alvarez AI, Prieto JG.
1991.
Effects of ethanol on the pharmacokinetics of cephalexin and cefadroxil in the rat. J Pharm Sci
80:511–516. doi: 10.1002/jps.2600800602. [PubMed] [CrossRef] [Google Scholar]

15. Dong H, Zhang J, Ren L, Liu Q, Zhu S.
2013.
Unexpected death due to cefuroxime-induced disulfiram-like reaction. Indian J Pharmacol
45:399–400. doi: 10.4103/0253-7613.114991. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

16. Kline SS, Mauro VF, Forney RB Jr, Freimer EH, Somani P.
1987.
Cefotetan-induced disulfiram-type reactions and hypoprothrombinemia. Antimicrob Agents Chemother
31:1328–1331. doi: 10.1128/aac.31.9.1328. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

17. Reeves DS, Davies AJ.
1980.
Antabuse effect with cephalosporins. Lancet
2:540. doi: 10.1016/s0140-6736(80)91868-1. [PubMed] [CrossRef] [Google Scholar]

18. Ren S, Cao Y, Zhang X, Jiao S, Qian S, Liu P.
2014.
Cephalosporin induced disulfiram-like reaction: a retrospective review of 78 cases. Int Surg
99:142–146. doi: 10.9738/INTSURG-D-13-00086.1. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

19. Small SM, Bacher RS, Jost SA.
2018.
Disulfiram-like reaction involving ceftriaxone in a pediatric patient. J Pediatr Pharmacol Ther
23:168–171. doi: 10.5863/1551-6776-23.2.168. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

20. Uri JV, Parks DB.
1983.
Disulfiram-like reaction to certain cephalosporins. Ther Drug Monit
5:219–224. doi: 10.1097/00007691-198306000-00013. [PubMed] [CrossRef] [Google Scholar]

21. Billstein SA, Sudol TE.
1992.
Disulfiram-like reactions rare with ceftriaxone. Geriatrics
47:70. [PubMed] [Google Scholar]

22. Moskovitz BL.
1984.
Clinical adverse effects during ceftriaxone therapy. Am J Med
77:84–88. [PubMed] [Google Scholar]

23. Emmerson AM, Jones AM.
2003.
The quinolones: decades of development and use. J Antimicrob Chemother
51(Suppl 1):13–20. doi: 10.1093/jac/dkg208. [PubMed] [CrossRef] [Google Scholar]

24. Olsen KM, Gentry-Nielsen M, Yue M, Snitily MU, Preheim LC.
2006.
Effect of ethanol on fluoroquinolone efficacy in a rat model of pneumococcal pneumonia. Antimicrob Agents Chemother
50:210–219. doi: 10.1128/AAC.50.1.210-219.2006. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

25. Lagoudianakis E, Pappas A, Koronakis N, Dallianoudis I, Kotzadimitriou K, Chrysikos J, Koukoutsis I, Antonakis P, Keramidaris D, Manouras A.
2009.
Recurrent erythema multiforme after alcohol ingestion in a patient receiving ciprofloxacin: a case report. Cases J
2:7787. doi: 10.4076/1757-1626-2-7787. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

26. Rapp RP, McCraney SA, Goodman NL, Shaddick DJ.
1994.
New macrolide antibiotics: usefulness in infections caused by mycobacteria other than Mycobacterium tuberculosis. Ann Pharmacother
28:1255–1263. doi: 10.1177/106002809402801109. [PubMed] [CrossRef] [Google Scholar]

27. Mandell LA, Wunderink RG, Anzueto A, Bartlett JG, Campbell GD, Dean NC, Dowell SF, File TM Jr, Musher DM, Niederman MS, Torres A, Whitney CG, Infectious Diseases Society of America, American Thoracic Society. 2007.
Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis
44(Suppl 2):S27–S72. doi: 10.1086/511159. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

28. Sturgill MG, Rapp RP.
1992.
Clarithromycin: review of a new macrolide antibiotic with improved microbiologic spectrum and favorable pharmacokinetic and adverse effect profiles. Ann Pharmacother
26:1099–1108. doi: 10.1177/106002809202600912. [PubMed] [CrossRef] [Google Scholar]

29. Morasso MI, Chavez J, Gai MN, Arancibia A.
1990.
Influence of alcohol consumption on erythromycin ethylsuccinate kinetics. Int J Clin Pharmacol Ther Toxicol
28:426–429. [PubMed] [Google Scholar]

30. Edelbroek MA, Horowitz M, Wishart JM, Akkermans LM.
1993.
Effects of erythromycin on gastric emptying, alcohol absorption and small intestinal transit in normal subjects. J Nucl Med
34:582–588. [PubMed] [Google Scholar]

31. Min DI, Noormohamed SE, Flanigan MJ.
1995.
Effect of erythromycin on ethanol’s pharmacokinetics and perception of intoxication. Pharmacotherapy
15:164–169. [PubMed] [Google Scholar]

32. Lim WS, Macfarlane JT, Colthorpe CL.
2001.
Pneumonia and pregnancy. Thorax
56:398–405. doi: 10.1136/thorax.56.5.398. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

33. Seitz C, Garcia P, Arancibia A.
1995.
Influence of ethanol ingestion on tetracycline kinetics. Int J Clin Pharmacol Ther
33:462–464. [PubMed] [Google Scholar]

34. Neuvonen PJ, Penttila O, Roos M, Tirkkonen J.
1976.
Effect of long-term alcohol consumption on the half-life of tetracycline and doxycycline in man. Int J Clin Pharmacol Biopharm
14:303–307. [PubMed] [Google Scholar]

35. Mattila MJ, Laisi U, Linnoila M, Salonen R.
1982.
Effect of alcoholic beverages on the pharmacokinetics of doxycycline in man. Acta Pharmacol Toxicol (Copenh)
50:370–373. doi: 10.1111/j.1600-0773.1982.tb00989.x. [PubMed] [CrossRef] [Google Scholar]

36. Yumuk Z, Dundar V.
2005.
The effect of long-term ethanol feeding on efficacy of doxycycline plus rifampicin in the treatment of experimental brucellosis caused by Brucella melitensis in rats. J Chemother
17:509–513. doi: 10.1179/joc.2005.17.5.509. [PubMed] [CrossRef] [Google Scholar]

37. Agrawal RG, Hewetson A, George CM, Syapin PJ, Bergeson SE.
2011.
Minocycline reduces ethanol drinking. Brain Behav Immun
25(Suppl 1):S165–S169. doi: 10.1016/j.bbi.2011.03.002. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

38. Wang X, Zhang K, Yang F, Ren Z, Xu M, Frank JA, Ke ZJ, Luo J.
2018.
Minocycline protects developing brain against ethanol-induced damage. Neuropharmacology
129:84–99. doi: 10.1016/j.neuropharm.2017.11.019. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

39. Procter and Gamble Pharmaceuticals. 2009. Macrobid-nitrofurantoin package insert. https://wwwaccessdatafdagov/drugsatfda_docs/label/2009/020064s019lblpdf.

40. Azarnoff DL, Hurwitz A.
1970.
Drug interactions. Pharmacol Physicians
4:1–7. [PubMed] [Google Scholar]

41. Petrie JDD, Howie J.
1975.
Drug interaction in general practice
In
Cluff LE, Petrie JC (ed), Clinical effects of interaction between drugs. Excerpta Medica, Amsterdam, Netherlands. [Google Scholar]

42. D’arcy PM.
1980.
Food and drug interaction: influence of food on drug bioavailability and toxicity. Pharm Int
I:238–244. [Google Scholar]

43. Rowles B, Worthen DB.
1982.
Clinical drug information: a case of misinformation. N Engl J Med
306:113–114. [PubMed] [Google Scholar]

44. Miura K, Reckendorf HK.
1967.
The nitrofurans. Prog Med Chem
5:320–381. doi: 10.1016/s0079-6468(08)70446-6. [PubMed] [CrossRef] [Google Scholar]

45. Edwards DI.
1980.
Mechanisms of selective toxicity of metronidazole and other nitroimidazole drugs. Br J Vener Dis
56:285–290. doi: 10.1136/sti.56.5.285. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

46. Pfizer. January
2018.
Flagyl (metronidazole) (prescribing information). Pfizer, New York, NY. [Google Scholar]

47. Taylor JA.
1964.
Metronidazole—a new agent for combined somatic and psychic therapy of alcoholism. a case study and preliminary report. Bull Los Angel Neuro Soc
29:158–162. [PubMed] [Google Scholar]

48. Semer JM, Friedland P, Vaisberg M, Greenberg A.
1966.
The use of metronidazole in the treatment of alcoholism: a pilot study. Am J Psychiatry
123:722–724. doi: 10.1176/ajp.123.6.722. [PubMed] [CrossRef] [Google Scholar]

49. Friedland P, Vaisberg M.
1968.
The use of metronidazole in the treatment of alchoholism. (A further study). Dis Nerv Syst
29:326–327. [PubMed] [Google Scholar]

50. Sansoy OM.
1970.
Evaluation of metronidazole in the treatment of alcoholism. A comprehensive three-year study comprising 60 cases. Rocky Mt Med J
67:43–47. [PubMed] [Google Scholar]

51. Lehmann HE, Ban TA.
1967.
Chemical reduction of the compulsion to drink with metronidazole: a new treatment modality in the therapeutic program of the alcoholic. Curr Ther Res Clin Exp
9:419–428. [PubMed] [Google Scholar]

52. Egan WP, Goetz R.
1968.
Effect of metronidazole on drinking by alcoholics. Q J Stud Alcohol
29:899–902. [PubMed] [Google Scholar]

53. Gallant DM, Bishop MP, Camp E, Tisdale C.
1968.
A six-month controlled evaluation of metronidazole (Flagyl) in chronic alcoholic patients. Curr Ther Res Clin Exp
10:82–87. [PubMed] [Google Scholar]

54. Gelder MG, Edwards G.
1968.
Metronidazole in the treatment of alcohol addiction. A controlled trial. Br J Psychiatry
114:473–475. doi: 10.1192/bjp.114.509.473. [PubMed] [CrossRef] [Google Scholar]

55. Goodwin DW.
1967.
Metronidazole in the treatment of alcoholism: a negative report. Am J Psychiatry
123:1276–1278. doi: 10.1176/ajp.123.10.1276. [PubMed] [CrossRef] [Google Scholar]

56. Goodwin DW, Reinhard J.
1972.
Disulfiramlike effects of trichomonacidal drugs. A review and double-blind study. Q J Stud Alcohol
33:734–740. [PubMed] [Google Scholar]

57. Kaplan R, Blume S, Rosenberg S, Pitrelli J, Turner WJ.
1972.
Phenytoin, metronidazole and multivitamins in the treatment of alcoholism. Q J Stud Alcohol
33:94–104. [PubMed] [Google Scholar]

58. Lal S.
1969.
Metronidazole in the treatment of alcoholism. A clinical trial and review of the literature. Q J Stud Alcohol
30:140–151. [PubMed] [Google Scholar]

59. Linton PH, Hain JD.
1967.
Metronidazole in the treatment of alcoholism. Q J Stud Alcohol
28:544–546. [PubMed] [Google Scholar]

60. Lysloff GO.
1972.
Anti-addictive chemotherapy—metronidazole and alcohol aversion. Br J Addict Alcohol Other Drugs
67:239–244. doi: 10.1111/j.1360-0443.1972.tb01202.x. [PubMed] [CrossRef] [Google Scholar]

61. Merry J, Whitehead A.
1968.
Metronidazole and alcoholism. Br J Psychiatry
114:859–861. doi: 10.1192/bjp.114.512.859. [PubMed] [CrossRef] [Google Scholar]

62. Penick SB, Carrier RN, Sheldon JB.
1969.
Metronidazole in the treatment of alcoholism. Am J Psychiatry
125:1063–1066. doi: 10.1176/ajp.125.8.1063. [PubMed] [CrossRef] [Google Scholar]

63. Penick SB, Sheldon JB, Templer DI, Carrier RN.
1971.
Four year follow-up of metronidazole treatment program for alcoholism. IMS Ind Med Surg
40:30–32. [PubMed] [Google Scholar]

64. Strassman HD, Adams B, Pearson AW.
1970.
Metronidazole effect on social drinkers. Q J Stud Alcohol
31:394–398. [PubMed] [Google Scholar]

65. Seinson RP.
1971.
Long term trial of metronidazole in male alcoholics. Br J Psychiatry
119:85–89. doi: 10.1192/bjp.119.548.85. [PubMed] [CrossRef] [Google Scholar]

66. Tyndel M, Fraser JG, Hartleib CJ.
1969.
Metronidazole as an adjuvant in the treatment of alcoholism. Br J Addict Alcohol Other Drugs
64:57–61. doi: 10.1111/j.1360-0443.1969.tb01109.x. [PubMed] [CrossRef] [Google Scholar]

67. Edwards JA, Price J.
1967.
Metronidazole and human alcohol dehydrogenase. Nature
214:190–191. doi: 10.1038/214190b0. [PubMed] [CrossRef] [Google Scholar]

68. Fried R, Fried LW.
1968.
Inhibition of oxidizing enzymes by metronidazole. Experientia
24:56–57. doi: 10.1007/bf02136791. [PubMed] [CrossRef] [Google Scholar]

69. Gupta NK, Woodley CL, Fried R.
1970.
Effect of metronidazole on liver alcohol dehydrogenase. Biochem Pharmacol
19:2805–2808. doi: 10.1016/0006-2952(70)90108-5. [PubMed] [CrossRef] [Google Scholar]

70. Tillonen J, Vakevainen S, Salaspuro V, Zhang Y, Rautio M, Jousimies-Somer H, Lindros K, Salaspuro M.
2000.
Metronidazole increases intracolonic but not peripheral blood acetaldehyde in chronic ethanol-treated rats. Alcoholism Clin Exp Res
24:570–575. doi: 10.1111/j.1530-0277.2000.tb02026.x. [PubMed] [CrossRef] [Google Scholar]

71. Visapaa JP, Tillonen JS, Kaihovaara PS, Salaspuro MP.
2002.
Lack of disulfiram-like reaction with metronidazole and ethanol. Ann Pharmacother
36:971–974. doi: 10.1345/aph.1A066. [PubMed] [CrossRef] [Google Scholar]

72. Mission Pharmacal Company. August
2007.
Tindamax (tinidazole) (prescribing information). Mission Pharmacal Company, San Antonio, TX. [Google Scholar]

73. Lupin Pharmaceuticals. October
2017.
Solosec (secnidazole) (prescribing information). Lupin Pharmaceuticals, Baltimore, MD. [Google Scholar]

74. Hoffmann-La Roche, Inc. June
2013.
Bactrim (sulfamethoxazole and trimethoprim) (prescribing information). Hoffmann-La Roche, Inc., Philadelphia, PA:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/017377s068s073lbl.pdf. [Google Scholar]

75. Heelon MW, White M.
1998.
Disulfiram-cotrimoxazole reaction. Pharmacotherapy
18:869–870. [PubMed] [Google Scholar]

76. Leslie RD, Pyke DA.
1978.
Chlorpropamide-alcohol flushing: a dominantly inherited trait associated with diabetes. Br Med J
2:1519–1521. doi: 10.1136/bmj.2.6151.1519. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

77. Hillson RM, Hockaday TD.
1984.
Chlorpropamide-alcohol flush: a critical reappraisal. Diabetologia
26:6–11. doi: 10.1007/bf00252254. [PubMed] [CrossRef] [Google Scholar]

78. Groop L, Eriksson CJ, Huupponen R, Ylikahri R, Pelkonen R.
1984.
Roles of chlorpropamide, alcohol and acetaldehyde in determining the chlorpropamide-alcohol flush. Diabetologia
26:34–38. doi: 10.1007/bf00252260. [PubMed] [CrossRef] [Google Scholar]

79. Carulli N, Manenti F, Gallo M, Salvioli GF.
1971.
Alcohol-drugs interaction in man: alcohol and tolbutamide. Eur J Clin Invest
1:421–424. doi: 10.1111/j.1365-2362.1971.tb00552.x. [PubMed] [CrossRef] [Google Scholar]

80. Flanagan S, Bartizal K, Minassian SL, Fang E, Prokocimer P.
2013.
In vitro, in vivo, and clinical studies of tedizolid to assess the potential for peripheral or central monoamine oxidase interactions. Antimicrob Agents Chemother
57:3060–3066. doi: 10.1128/AAC.00431-13. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

81. Antal EJ, Hendershot PE, Batts DH, Sheu WP, Hopkins NK, Donaldson KM.
2001.
Linezolid, a novel oxazolidinone antibiotic: assessment of monoamine oxidase inhibition using pressor response to oral tyramine. J Clin Pharmacol
41:552–562. doi: 10.1177/00912700122010294. [PubMed] [CrossRef] [Google Scholar]

82. Cantarini MV, Painter CJ, Gilmore EM, Bolger C, Watkins CL, Hughes AM.
2004.
Effect of oral linezolid on the pressor response to intravenous tyramine. Br J Clin Pharmacol
58:470–475. doi: 10.1111/j.1365-2125.2004.02186.x. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

83. Pharmacia and Upjohn. July
2018.
Zyvox (linezolid) (prescribing information). Pharmacia and Upjohn, New York, NY. [Google Scholar]

84. Rumore MM, Roth M, Orfanos A.
2010.
Dietary tyramine restriction for hospitalized patients on linezolid: an update. Nutr Clin Pract
25:265–269. doi: 10.1177/0884533610368711. [PubMed] [CrossRef] [Google Scholar]

85. Da Prada M, Zurcher G, Wuthrich I, Haefely WE.
1988.
On tyramine, food, beverages and the reversible MAO inhibitor moclobemide. J Neural Transm Suppl
26:31–56. [PubMed] [Google Scholar]

86. Merck. October
2016.
Sivextro (tedizolid) (prescribing information). Merck, Whitehouse Station, NJ. [Google Scholar]

87. Holden K.
2006.
Meal ideas and menus: avoiding high-tyramine foods made easy. Teva Neuroscience, Inc, Kansas City, MO:
https://www.mc.vanderbilt.edu/documents/neurology/files/Tyramine%20Menu%20Book%2006227101.pdf. [Google Scholar]

88. Albengres E, Le Louet H, Tillement JP.
1998.
Systemic antifungal agents. Drug interactions of clinical significance. Drug Saf
18:83–97. doi: 10.2165/00002018-199818020-00001. [PubMed] [CrossRef] [Google Scholar]

89. Katz HI, Gupta AK.
1997.
Oral antifungal drug interactions. Dermatol Clin
15:535–544. doi: 10.1016/s0733-8635(05)70460-5. [PubMed] [CrossRef] [Google Scholar]

90. Magnasco AJ, Magnasco LD.
1986.
Interaction of ketoconazole and ethanol. Clin Pharm
5:522–523. [PubMed] [Google Scholar]

91. Fazio RA, Wickremesinghe PC, Arsura EL.
1983.
Ketoconazole treatment of Candida esophagitis—a prospective study of 12 cases. Am J Gastroenterol
78:261–264. [PubMed] [Google Scholar]

92. Pfizer. 2010.
Fluconazole (prescribing information). Pfizer, New York, NY. [Google Scholar]

93. Ortho Dermatologics. 2011.
Grifulvin V (prescribing information). https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/062279s022lbl.pdf.

94. Gilman AR, Nies A.
1990.
Goodman and Gilman’s the pharmacological basis of therapeutics, vol 8
Pergamon Press, New York, NY. [Google Scholar]

95. Robinson MM.
1959.
Griseofulvin therapy of superficial mycoses. Antibiot Annu
7:680–686. [PubMed] [Google Scholar]

96. Simon HR.
1961.
Untoward reactions to antimicrobial agents. Griseofulvin. Annu Rev Med
12:119–120. [Google Scholar]

97. Fett DL, Vukov LF.
1994.
An unusual case of severe griseofulvin-alcohol interaction. Ann Emerg Med
24:95–97. doi: 10.1016/s0196-0644(94)70167-9. [PubMed] [CrossRef] [Google Scholar]

98. Nahid P, Dorman SE, Alipanah N, Barry PM, Brozek JL, Cattamanchi A, Chaisson LH, Chaisson RE, Daley CL, Grzemska M, Higashi JM, Ho CS, Hopewell PC, Keshavjee SA, Lienhardt C, Menzies R, Merrifield C, Narita M, O’Brien R, Peloquin CA, Raftery A, Saukkonen J, Schaaf HS, Sotgiu G, Starke JR, Migliori GB, Vernon A.
2016.
Official American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America clinical practice guidelines: treatment of drug-susceptible tuberculosis. Clin Infect Dis
63:e147–e195. doi: 10.1093/cid/ciw376. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

99. Yew WW, Wong CF, Wong PC, Lee J, Chau CH.
1993.
Adverse neurological reactions in patients with multidrug-resistant pulmonary tuberculosis after coadministration of cycloserine and ofloxacin. Clin Infect Dis
17:288–289. doi: 10.1093/clinids/17.2.288. [PubMed] [CrossRef] [Google Scholar]

100. Rothstein DM.
2016.
Rifamycins, alone and in combination. Cold Spring Harb Perspect Med
6:a027011. doi: 10.1101/cshperspect.a027011. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

101. Cross FS, Long MW, Banner AS, Snider DE Jr.
1980.
Rifampin-isoniazid therapy of alcoholic and nonalcoholic tuberculous patients in a U.S. Public Health Service Cooperative Therapy Trial. Am Rev Respir Dis
122:349–353. [PubMed] [Google Scholar]

102. Dossing M, Wilcke JT, Askgaard DS, Nybo B.
1996.
Liver injury during antituberculosis treatment: an 11-year study. Tuber Lung Dis
77:335–340. doi: 10.1016/s0962-8479(96)90098-2. [PubMed] [CrossRef] [Google Scholar]

103. Bouazzi OE, Hammi S, Bourkadi JE, Tebaa A, Tanani DS, Soulaymani-Bencheikh R, Badrane N, Bengueddour R.
2016.
First line anti-tuberculosis induced hepatotoxicity: incidence and risk factors. Pan Afr Med J
25:167. doi: 10.11604/pamj.2016.25.167.10060. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

104. Sanofi-Aventis. 2019.
Rifadin (rifampin) (prescribing information). Sanofi-Aventis, Bridgewater, NJ:
http://products.sanofi.us/rifadin/Rifadin.pdf. [Google Scholar]

105. Kopanoff DE, Snider DE Jr, Caras GJ.
1978.
Isoniazid-related hepatitis: a U.S. Public Health Service cooperative surveillance study. Am Rev Respir Dis
117:991–1001. [PubMed] [Google Scholar]

106. Vasiliou V, Malamas M, Marselos M.
1986.
The mechanism of alcohol intolerance produced by various therapeutic agents. Acta Pharmacol Toxicol (Copenh)
58:305–310. doi: 10.1111/j.1600-0773.1986.tb00114.x. [PubMed] [CrossRef] [Google Scholar]

107. Baciewicz AM, Self TH.
1985.
Isoniazid interactions. South Med J
78:714–718. doi: 10.1097/00007611-198506000-00025. [PubMed] [CrossRef] [Google Scholar]

108. Noureldin M, Kj JL, Tran M.
2010.
Drug-alcohol interactions: a review of three therapeutic classes. US Pharmacist
35:29–33. [Google Scholar]

109. Hauser MJ, Baier H.
1982.
Interactions of isoniazid with foods. Drug Intell Clin Pharm
16:617–618. doi: 10.1177/106002808201600718. [PubMed] [CrossRef] [Google Scholar]

110. Kaneko T, Ishigatsubo Y.
2005.
Isoniazid and food interactions: –fish, cheese, and wine. Intern Med
44:1120–1121. doi: 10.2169/internalmedicine.44.1120. [PubMed] [CrossRef] [Google Scholar]

111. Karamanakos PN, Pappas P, Boumba V, Vougiouklakis T, Marselos M.
2016.
The alcohol intolerance produced by isoniazid is not due to a disulfiram-like reaction despite aldehyde dehydrogenase inhibition. Pharmacology
98:267–271. doi: 10.1159/000448759. [PubMed] [CrossRef] [Google Scholar]

112. Patheon Inc. January
2007.
Myambutol (ethambutol) (prescribing information). Patheon Inc, Toronto, Canada:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/016320s063lbl.pdf. [Google Scholar]

113. Wyeth Pharmaceuticals. April
2018.
Trecator (ethionamide) (prescribing information). Wyeth Pharmaceuticals Inc, Philadelphia, PA:
https://www.pfizermedicalinformation.com/en-us/trecator. [Google Scholar]

114. Gryminski J, Lyczewska J, Styszewska H, Walczak J.
1970.
Evaluation of the hepatotoxic effect of antituberculous drugs in tuberculosis patients abusing alcohol. Pol Med J
9:635–644. [PubMed] [Google Scholar]

115. Lansdown FS, Beran M, Litwak T.
1967.
Psychotoxic reaction during ethionamide therapy. Am Rev Respir Dis
95:1053–1055. doi: 10.1164/arrd.1967.95.6.1053. [PubMed] [CrossRef] [Google Scholar]

116. Par Pharmaceutical. July
2018.
Pyrazinamide (prescribing information). Par Pharmaceutical, Columbus, Ohio. [Google Scholar]

117. Lee AM, Mennone JZ, Jones RC, Paul WS.
2002.
Risk factors for hepatotoxicity associated with rifampin and pyrazinamide for the treatment of latent tuberculosis infection: experience from three public health tuberculosis clinics. Int J Tuber Lung Dis
6:995–1000. [PubMed] [Google Scholar]

118. Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, Daley C, Gordin F, Holland SM, Horsburgh R, Huitt G, Iademarco MF, Iseman M, Olivier K, Ruoss S, von Reyn CF, Wallace RJ Jr, Winthrop K, Subcommittee A, American Thoracic Society, Infectious Disease Society of America. 2007.
An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med
175:367–416. doi: 10.1164/rccm.200604-571ST. [PubMed] [CrossRef] [Google Scholar]

119. Kiefer F, Kirsch M, Bach P, Hoffmann S, Reinhard I, Jorde A, von der Goltz C, Spanagel R, Mann K, Loeber S, Vollstadt-Klein S.
2015.
Effects of d-cycloserine on extinction of mesolimbic cue reactivity in alcoholism: a randomized placebo-controlled trial. Psychopharmacology (Berl)
232:2353–2362. doi: 10.1007/s00213-015-3882-5. [PubMed] [CrossRef] [Google Scholar]

120. MacKillop J, Few LR, Stojek MK, Murphy CM, Malutinok SF, Johnson FT, Hofmann SG, McGeary JE, Swift RM, Monti PM.
2015.
d-Cycloserine to enhance extinction of cue-elicited craving for alcohol: a translational approach. Transl Psychiatry
5:e544. doi: 10.1038/tp.2015.41. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

121. Kamboj SK, Massey-Chase R, Rodney L, Das R, Almahdi B, Curran HV, Morgan CJ.
2011.
Changes in cue reactivity and attentional bias following experimental cue exposure and response prevention: a laboratory study of the effects of d-cycloserine in heavy drinkers. Psychopharmacology (Berl)
217:25–37. doi: 10.1007/s00213-011-2254-z. [PubMed] [CrossRef] [Google Scholar]

122. Lilly. April
2005.
Seromycin (cycloserine) (prescribing information). Lilly, Indianapolis, IN. [Google Scholar]

123. Valeant Pharmaceuticals. April
2016.
Gris-PEG (griseofluvin) (prescribing information). Valeant Pharmaceuticals, Bridgewater, NJ. [Google Scholar]

124. Epic Pharma. 2016.
Isoniazid prescribing information. Epic Pharma, Laurelton, NY. [Google Scholar]

Can I drink alcohol with antibiotics and how long after antibiotics can I drink alcohol

What to do?

Anonymous

asked in the Community T⁠—⁠F

A month ago I caught a cold – or rather, I thought so. The disease developed into something similar to bronchitis, and yesterday the doctor diagnosed pneumonia and prescribed antibiotics. But there is a problem: on the weekend, my father’s birthday is 60 years. There will be a festive table and alcohol.

I have a question: how dangerous is it to combine alcohol and antibiotics, and what happens if you still drink so as not to offend your father and guests?

Daniil Davydov

medical journalist

Author profile

Alcohol does not affect the effectiveness of most antibiotics – drugs will fight pathogenic bacteria as effectively as if you did not drink. However, some antibiotics interact with alcohol. Because of this, adverse reactions may occur that would otherwise be avoided.

What are antibiotics

Antibiotics are medicines that fight bacterial infections in humans and animals. These are bacterial poisons that act on vulnerable points of microbes. As a result, the latter either die or lose the ability to grow and multiply. Viruses do not have vulnerable points characteristic of bacteria, so antibiotics do not work on them.

Like all medicines, antibiotics can cause side effects. The problem is that when taken together with some antibiotics, alcohol not only increases unwanted reactions to the drug, but can also provoke new ones.

Why you shouldn’t mix antibiotics and alcohol – American Addiction Center

How alcohol affects how antibiotics work

In addition to antibiotics, antidepressants, antihistamines, barbiturates, benzodiazepines, painkillers, anti-inflammatory drugs are not combined with alcohol. Even some herbal medicines can cause negative effects when taken with alcohol.

Alcohol and Drug Interactions – Journal of Alcohol and Health ResearchPDF, 99 KB

Alcohol interacts with drugs in two ways.

Alcohol interferes with drug metabolism. A small amount of ethyl alcohol is constantly produced in our body – this is a normal process. But the excess ethyl alcohol that enters the body along with alcoholic beverages, like most drugs, including antibiotics, it perceives as a poison.

Over-the-counter drugs in combination with alcohol can also turn into poison – US National Institute of Alcohol Addiction and Alcoholism

Special proteins, enzymes produced by the liver, are responsible for neutralizing poisons. If not only an antibiotic, but also excess alcohol enters the liver, the load on enzymes increases. As a result, they either do not have time to do their job, or, conversely, do it too quickly. In the first case, the level of the antibiotic in the body increases, and this can lead to greater toxicity of the drug and side effects that could have been avoided with the exact dosage. And in the second case, the antibiotic is destroyed too quickly – before it has time to act.

Alcohol inhibits enzymes and increases antibiotic toxicity – International Drug Database Drugs

Alcohol increases the side effects of the drug and provokes new ones. For example, metronidazole itself causes drowsiness and suppresses attention, and alcohol further enhances these effects. As a result, a person runs the risk of simply falling asleep at the festive table.

Alcohol and metronidazole – NHS

In addition, metronidazole in combination with alcohol has additional side effects such as headache, nausea, abdominal pain and arrhythmia. No one knows why this happens: the interaction of this antibiotic with alcohol has not yet been sufficiently studied.

In addition to alcohol, antibiotics are not compatible with other drugs. These are anticoagulants such as warfarin, anticonvulsants such as phenytoin and phenobarbital, antidiabetic drugs in tablets such as tolbutamide. Therefore, before you start taking antibiotics, you need to tell your doctor about all your diseases and the medicines that you take.

Antibiotics: what are the differences and how to take them

Can I drink alcohol at the same time as antibiotics

It depends on which antibiotic to take along with alcohol and what kind of relationship a person has with alcohol.

Alcohol and Antibiotic Interactions – Journal of Antimicrobials and ChemotherapyPDF, 536KB

Erythromycin. Even small doses of alcohol accelerate the work of liver enzymes that are responsible for the processing of the drug. As a result, the medicine may not work – additional doses will be required.

Ketoconazole and griseofulvin. If a person drinks alcohol on the same day as one of these drugs, the risk of developing a disulfiram-like reaction will increase – this is the name for a condition similar to a very severe hangover. A person is sick and vomits, his head is splitting, and some even have pains in the chest and stomach.

Doxycycline. In people suffering from chronic alcoholism, doxycycline accelerates the work of liver enzymes that are responsible for the processing of the drug. That is why alcohol-dependent people require higher dosages of this medicine.

At the same time, not all antibiotics are equally badly combined with alcohol. There are drugs that are relatively safe to take alcohol at the same time. Moderate doses of alcohol, i.e. no more than one standard drink per day for women and two for men, are compatible:

  • with oral penicillins, fluoroquinolones and tetracyclines;
  • some cephalosporins – cefdinir and cefpodoxime;
  • azithromycin;
  • nitrofurantoin.

Standard drink of alcohol is 14 g of pure ethanol – National Institute of Alcohol Addiction and Alcoholism USA

How long after taking antibiotics can you drink alcohol

There is no consensus on this issue. British Ministry of Health experts say that it is enough to wait 48 hours after the end of the course. It is believed that this time is sufficient to remove the antibiotic from the body. And a pharmacist at Drugs thinks it’s safer not to drink alcohol for at least 72 hours after you’ve stopped taking your medication.

Do not drink alcohol 48 hours after stopping antibiotics – NHS

Do not drink alcohol 72 hours after stopping antibiotics – Drugs

It is difficult to say which advice is more accurate. But perhaps it makes sense to wait at least two days.

So to drink or not to drink

Although some antibiotics are combined with moderate doses of alcohol, alcohol is still not recommended for patients who are being treated for bacterial infections. Alcoholic drinks not only affect the functioning of liver enzymes, but also disrupt normal sleep – all this interferes with a full recovery.

Alcohol prevents people from getting enough sleep – NGO Sleep Foundation

Even if your doctor has given you an alcohol-compatible antibiotic, it’s still safer not to drink, even in honor of the holiday.

What to do? Readers ask – experts answer

Medical myths: Is alcohol compatible with antibiotics?

  • Claudia Hammond
  • BBC Future

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Image copyright Thinkstock

Medical studies show that alcohol does not block the effects of most medications and does not usually cause side effects when combined with medications. But we should not forget about some other important points, the correspondent of warns
BBC Future .

Women in the early stages of pregnancy, not yet ready to share this joyful news with others, are well aware that others can easily guess everything themselves if the expectant mother refuses to drink at a party.

But there is a good excuse: you can tell colleagues and friends that you are being treated with antibiotics, and all questions will disappear. Even excessively curious acquaintances are unlikely to inquire why the medicine was prescribed.

But is it really necessary to abstain from alcohol in combination with a course of antibiotics?

(More BBC Future articles in Russian)

Some believe that alcohol can prevent the drug from working, others believe that this combination causes side effects.

The staff of one of the urogenital clinics in London interviewed 300 patients – it turned out that 81% of them adhered to the first point of view, and 71% – the second.

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But with most antibiotics, neither is true. From the point of view of doctors, it is much more dangerous when a patient who believes in one of these myths decides not to take the medicine after drinking a glass of wine.

Any factor that causes a drug to be skipped exacerbates the serious global problem of bacterial resistance to antibiotics.

In fact, alcohol does not interfere with most commonly used antibiotics.

But there are exceptions: for example, the drug of the cephalosporin group cefocetane slows down the process of splitting alcohol, resulting in an increase in the level of acetaldehyde in the body.

And this can lead to undesirable consequences in the form of dizziness, vomiting, flushing of the face, headaches, shortness of breath and chest pain.

Disulfiram, a drug sometimes used in the treatment of alcohol dependence, has similar side effects. The idea is that the patient in treatment begins to feel bad after drinking – which in theory should make him stop drinking further.

These sensations are unpleasant, therefore, during treatment with cefocetane and disulfiram (and for several days after the end of the course), you should abstain from alcohol.

Another antibiotic that is poorly compatible with alcohol is metronidazole. It is used in the treatment of infections in the mouth, infected leg ulcers and bedsores. It is believed that in combination with alcohol, it gives the same side effects as the already mentioned cephalosporins.

Photo caption,

Of course there are different types of antibiotics. But most of them are not affected by alcohol

However, this view was called into question after a 2003 analysis of pharmacological studies. In addition, an experiment was made on a small control group of Finnish men, during which they consumed alcohol with metronidazole for five days without any unpleasant consequences.

However, the authors of this study acknowledge that the possibility of adverse effects cannot be completely ruled out, and doctors still do not recommend combining alcohol with metronidazole.

There are several other antibiotics that are best avoided when taking alcohol, such as tinedazole, linezolid, and erythromycin. But this incompatibility is well known, and doctors specifically warn patients about it when prescribing a medicine.

This leaves a long list of other antibiotics that are safe to drink. Of course, alcohol is unlikely to help cure the disease: it can make your body dehydrated and lethargic, but this has nothing to do with drugs.

Perhaps the myth about the incompatibility of antibiotics and alcohol appeared after some separate unpleasant cases, but there are two more interesting theories.

One is that antibiotics are used in the treatment of common sexually transmitted diseases, and doctors allegedly punished patients for their dissolute behavior by forbidding them to drink a glass or two.

There is another explanation given by James Bingham, one of the authors of the above-mentioned survey of patients at the London Urogenital Clinic.

He met with retired Brigadier General Ian Fraser, who began using penicillin to treat wounded soldiers in North Africa during World War II.

At that time, there was so little penicillin that after taking the drug inside, urine was taken from patients and the drug was again isolated from it.

The soldiers who were treated were allowed to drink beer, but this led to an increase in the volume of urine produced by the body and, as a result, complicated the extraction of medicine. According to General Fraser, therefore, the command decided to ban beer.

Agree, a good story, regardless of whether it influenced the spread of the myth about the incompatibility of alcohol and antibiotics.

But debunking myths is a double-edged sword. When a patient who cannot live without a glass of wine nevertheless diligently drinks a course of antibiotics, this is good, because it helps fight drug resistance in bacteria.

But if the general public learns the whole truth, then women who do not want to talk about their pregnancy will have to be more creative in refusing alcohol at parties.