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Can i take zinc and vitamin c together. Zinc and Vitamin C: Ineffective for COVID-19 Treatment, Cleveland Clinic Study Reveals

Can zinc and vitamin C supplements help treat COVID-19. Are these common over-the-counter remedies effective against coronavirus symptoms. What does the latest research say about using zinc and vitamin C for COVID-19 patients. How do these supplements impact recovery time and symptom severity in coronavirus cases.

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Cleveland Clinic’s Groundbreaking Study on Zinc and Vitamin C for COVID-19

A recent study conducted by Cleveland Clinic researchers has shed new light on the efficacy of zinc and vitamin C supplements in treating COVID-19. The findings, published in JAMA Open Network, have significant implications for those seeking alternative treatments for the coronavirus.

Key Findings of the COVIDAtoZ Clinical Trial

The COVIDAtoZ clinical trial enrolled 214 adult patients with confirmed COVID-19 infections. Researchers randomized patients into four groups, each receiving different treatments over a 10-day period:

  • Zinc gluconate (50 mg)
  • Vitamin C (8000 mg)
  • Both zinc gluconate and vitamin C
  • Standard care (control group)

The study’s primary endpoint was a 50% reduction in symptoms. Surprisingly, researchers found no significant difference in symptom reduction among the four groups.

Why Were Zinc and Vitamin C Considered Potential Treatments?

Zinc and vitamin C have long been associated with immune function and fighting infections. Zinc plays a role in antibody and white blood cell production, while vitamin C is an antioxidant that can help reduce cell damage and boost immunity. These properties led to widespread speculation about their potential in preventing or treating COVID-19.

The Impact of Supplements on COVID-19 Symptoms and Recovery

Despite the initial hopes, the Cleveland Clinic study found that zinc and vitamin C supplements, either alone or in combination, did not significantly decrease the severity or duration of COVID-19 symptoms compared to standard care.

Do Zinc and Vitamin C Help with Other Viral Illnesses?

While these supplements may not be effective for COVID-19, there is limited evidence suggesting that high doses of vitamin C and zinc might reduce the duration and severity of common cold symptoms. However, their efficacy in treating SARS-CoV-2 specifically appears to be minimal.

The Rise of Supplement Sales During the Pandemic

During the COVID-19 pandemic, sales of vitamin C and zinc supplements skyrocketed, particularly in countries like India. Many consumers turned to these over-the-counter remedies in hopes of boosting their immunity and protecting themselves against the virus.

Why Did Supplement Sales Increase?

The surge in supplement sales can be attributed to several factors:

  1. Marketing of these products as immunity boosters
  2. Public desire for accessible and affordable preventive measures
  3. Limited initial scientific evidence on COVID-19 treatments
  4. Historical use of these supplements for other viral illnesses

Implications of the Study for COVID-19 Treatment

The Cleveland Clinic study’s findings have important implications for both medical professionals and consumers. Dr. Milind Desai, co-principal investigator of the study, emphasized that when the trial began, there was no research to support supplemental therapy for COVID-19 prevention or treatment.

What Does This Mean for Current Treatment Protocols?

While vitamin C and zinc proved ineffective as treatments when clinically compared to standard care, the study of other therapeutics continues. Medical professionals are now better equipped to advise patients on the limitations of these supplements in treating COVID-19.

The Importance of Outpatient Studies in COVID-19 Research

The Cleveland Clinic study focused on outpatient management of COVID-19 cases, which is particularly relevant for individuals seeking at-home treatments. Dr. Suma Thomas, co-principal investigator, noted that not all COVID-19 patients require hospitalization, making this population crucial to study.

Why Are Outpatient Studies Significant?

Outpatient studies provide valuable insights into:

  • The effectiveness of easily accessible treatments
  • Patient behavior in managing symptoms at home
  • Potential risks and benefits of over-the-counter remedies
  • Guidance for public health recommendations

Safety Considerations in Supplement Use for COVID-19

While the study focused primarily on efficacy, safety was also a key consideration. Four safety events were observed during the trial, including three deaths. However, the data safety monitoring board did not believe that any of the adverse events were caused by the treatments administered as part of the study.

Are There Risks Associated with High-Dose Supplements?

Although the study did not find direct links between the supplements and adverse events, it’s important to note that high doses of any supplement can potentially have side effects. Consumers should always consult with healthcare professionals before starting any new supplement regimen, especially in the context of COVID-19 or other illnesses.

Effective Measures for Reducing COVID-19 Risk

While zinc and vitamin C supplements may not be effective in treating COVID-19, there are several proven steps individuals can take to reduce their risk of infection:

  1. Get vaccinated against COVID-19 when possible
  2. Practice social distancing
  3. Wash hands frequently
  4. Wear a mask in public settings

These measures, recommended by health authorities worldwide, remain the most effective ways to prevent COVID-19 transmission and protect oneself and others.

The Future of COVID-19 Treatment Research

The Cleveland Clinic study highlights the importance of rigorous scientific research in evaluating potential COVID-19 treatments. As the pandemic continues to evolve, researchers around the world are exploring various therapeutic options.

What Areas of Research Show Promise?

While zinc and vitamin C may not be effective, other areas of COVID-19 treatment research are showing promise:

  • Antiviral medications
  • Monoclonal antibody treatments
  • Repurposed existing drugs
  • Novel therapeutic approaches

Continued research and clinical trials are essential to identify safe and effective treatments for COVID-19.

The Role of Nutrition in Overall Health During the Pandemic

Although zinc and vitamin C supplements may not directly treat COVID-19, maintaining a balanced diet rich in vitamins and minerals remains crucial for overall health and immune function. A well-nourished body is better equipped to fight off infections and recover from illnesses.

What Nutritional Strategies Can Support Immune Health?

To support overall immune health, consider the following nutritional strategies:

  • Consume a variety of fruits and vegetables
  • Incorporate lean proteins and whole grains into your diet
  • Stay hydrated by drinking plenty of water
  • Limit processed foods and excessive sugar intake
  • Consider consulting a registered dietitian for personalized advice

The Importance of Evidence-Based Medicine in Public Health Crises

The Cleveland Clinic study underscores the critical role of evidence-based medicine in addressing public health crises like the COVID-19 pandemic. As new diseases emerge and evolve, it’s essential to rely on rigorous scientific research to guide treatment decisions and public health recommendations.

How Does Evidence-Based Medicine Benefit Society?

Evidence-based medicine offers several benefits during health crises:

  • Provides reliable information to guide treatment decisions
  • Helps allocate resources effectively
  • Reduces the spread of misinformation
  • Informs public health policies and guidelines
  • Enhances overall patient care and outcomes

The Challenge of Rapidly Evolving Information

During a pandemic, information and understanding of the disease can change rapidly. This presents challenges for both healthcare providers and the public in staying informed about the latest treatments and prevention strategies.

How Can Individuals Stay Informed About COVID-19 Research?

To stay up-to-date on the latest COVID-19 research and recommendations:

  1. Follow reputable health organizations like the WHO and CDC
  2. Consult with healthcare professionals for personalized advice
  3. Read peer-reviewed scientific publications
  4. Be cautious of unverified claims on social media
  5. Participate in community health education programs

The Global Impact of COVID-19 Research

Studies like the one conducted by Cleveland Clinic have far-reaching implications beyond their immediate findings. They contribute to the global body of knowledge about COVID-19 and inform treatment protocols worldwide.

How Does International Collaboration Advance COVID-19 Research?

International collaboration in COVID-19 research offers several advantages:

  • Pooling of resources and expertise
  • Faster development of treatments and vaccines
  • Sharing of data across diverse populations
  • Coordinated response to global health threats
  • Improved preparedness for future pandemics

The Role of Public Participation in Clinical Trials

The success of studies like the Cleveland Clinic trial depends on public participation. Volunteers who take part in clinical trials play a crucial role in advancing medical knowledge and potentially saving lives.

How Can Individuals Contribute to COVID-19 Research?

There are several ways individuals can contribute to COVID-19 research efforts:

  1. Volunteer for clinical trials when eligible
  2. Participate in health surveys and studies
  3. Donate to reputable research institutions
  4. Share accurate information about ongoing research
  5. Support policies that fund scientific research

Adapting to New Information in the Fight Against COVID-19

The Cleveland Clinic study on zinc and vitamin C supplements demonstrates the importance of adapting to new information in the ongoing battle against COVID-19. As our understanding of the virus evolves, so too must our approaches to prevention and treatment.

How Can Healthcare Systems Adapt to New COVID-19 Research?

Healthcare systems can adapt to new COVID-19 research by:

  • Implementing regular training for healthcare professionals
  • Updating treatment protocols based on the latest evidence
  • Investing in technology to disseminate new information quickly
  • Collaborating with research institutions for real-time data sharing
  • Engaging in public education campaigns to combat misinformation

The Role of Media in Communicating COVID-19 Research

Media outlets play a crucial role in disseminating information about COVID-19 research to the public. Responsible reporting can help combat misinformation and ensure that people have access to accurate, up-to-date information about the pandemic.

How Can Media Responsibly Report on COVID-19 Research?

To responsibly report on COVID-19 research, media outlets should:

  1. Consult with medical experts to interpret study results
  2. Provide context for research findings
  3. Avoid sensationalism and clickbait headlines
  4. Clearly differentiate between preliminary and peer-reviewed research
  5. Follow up on previous reports as new information becomes available

The Ongoing Search for Effective COVID-19 Treatments

While the Cleveland Clinic study may have ruled out zinc and vitamin C as effective treatments for COVID-19, the search for other potential therapies continues. Researchers worldwide are exploring various avenues to combat the virus and its effects.

What Other Potential Treatments Are Being Studied?

Some promising areas of COVID-19 treatment research include:

  • Antiviral drugs targeting specific viral mechanisms
  • Immunomodulators to regulate the body’s immune response
  • Convalescent plasma therapy
  • Combination therapies using multiple drugs
  • Novel vaccine technologies for prevention and treatment

The Importance of Continuing Research Efforts

Despite setbacks and negative results, it’s crucial to continue research efforts in the fight against COVID-19. Each study, regardless of its outcome, contributes to our overall understanding of the virus and helps guide future research directions.

How Can Research Findings Be Translated into Clinical Practice?

To effectively translate research findings into clinical practice:

  1. Develop clear clinical guidelines based on study results
  2. Implement continuing education programs for healthcare providers
  3. Create decision support tools for clinicians
  4. Engage in knowledge translation activities to bridge research and practice
  5. Monitor and evaluate the implementation of new practices

As the global community continues to grapple with the COVID-19 pandemic, studies like the one conducted by Cleveland Clinic serve as crucial guideposts in our understanding of the virus and potential treatments. While zinc and vitamin C supplements may not be the answer we hoped for, the pursuit of knowledge and effective therapies remains unwavering. By staying informed, following evidence-based recommendations, and supporting ongoing research efforts, we can collectively contribute to overcoming this unprecedented health challenge.

Cleveland Clinic Study Reveals Zinc and Vitamin C Not Effective Treatments for COVID-19 – Cleveland Clinic Newsroom

Cleveland Clinic researchers have found that zinc or ascorbic acid (vitamin C) – or a combination of the two – do not significantly decrease the severity or duration of symptoms in COVID-19-positive patients, when compared to standard care. The study was published today in JAMA Open Network.

Since the start of the COVID-19 pandemic there has been widespread speculation about the role of various vitamins and supplements to prevent or treat it, but there remains limited scientific evidence. Zinc is known to be important for immune function. It also has a role in antibody and white blood cell production and can fight infections. Vitamin C, an antioxidant, can help reduce damage to cells, and has shown to be immune-boosting.

The COVIDAtoZ clinical trial enrolled 214 adult patients with a confirmed COVID-19 infection. Patients were randomized and either received 10 days of zinc gluconate (50 mg), vitamin C (8000 mg), both agents, or standard of care from April 2020 to October 2020. The study was stopped for futility, with no significant difference among the four groups. Specifically the endpoint of a 50% reduction in symptoms showed no significant difference between the usual care, vitamin C, zinc gluconate or the group receiving both vitamin C and zinc gluconate.

“When we began this trial, there was no research to support supplemental therapy for the prevention or treatment of patients with COVID-19,” said Milind Desai, M.D., MBA, director, clinical operations in Cleveland Clinic’s Heart Vascular & Thoracic Institute and co-principal investigator of the study. “As we watched the pandemic spread across the globe, infecting and killing millions, the medical community and consumers alike scrambled to try supplements that they believed could possibly prevent infection, or ease COVID-19 symptoms, but the research is just now catching up. While vitamin C and zinc proved ineffective as a treatment when clinically compared to standard care, the study of other therapeutics continues.

The patients enrolled in this study were not hospitalized, but rather managed on an outpatient basis. “We know that not all patients with COVID-19 require hospital admission, and compared to those being treated in a hospital setting, they are more likely to be seeking out supplements that could help them, so it was an important population to study,” said Suma Thomas, M.D., MBA, vice-chairman of strategic operations in Cleveland Clinic’s Heart Vascular & Thoracic Institute and co-principal investigator of the study.

A total of four safety events were observed during the trial, including 3 deaths, however the data safety monitoring board did not believe that any of the adverse events were caused by individual treatments that patients received as a part of the study.

There are steps people can take to reduce the risk of infection. When possible, get a COVID-19 vaccine. Continue to socially distance, wash your hands often, and wear a mask in public.

Zinc, Vitamin C supplements do not help Covid patients recover, says study 

A woman undergoes a Covid-19 test | Representational image | Photo: ANI


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New Delhi: Vitamin C and zinc supplements do not help Covid-19 patients recover from their illness, a new study published in the journal JAMA Network Open has found.

Zinc and Vitamin C are commonly available, over-the-counter supplements that patients across the world take for the treatment of viral illnesses. 

Zinc is thought to aid the cells’ ability to fight off infection, and Vitamin C is an antioxidant that may play a role in immune response.

Sales of both Vitamin C and zinc supplements in India significantly shot up during the pandemic, since both are marketed as immunity boosters.  

Limited evidence suggests that high doses of Vitamin C and zinc may reduce duration of common cold symptoms and decrease the severity of symptoms.

The study

Until now, the role of zinc and Vitamin C in decreasing symptoms and improving recovery in patients diagnosed with SARS-CoV-2 infection was uncertain. 

So, a team from Cleveland Clinic in the US sought to determine whether either reduces the severity or duration of symptoms associated with SARS-CoV-2 compared with usual care.

For the study conducted from April to October 2020, researchers assessed how 214 adults with confirmed Covid-19 infection responded to 10 days of zinc supplements, 10 days of vitamin C, both, or usual care.

There was no significant difference among the four groups in reduction of Covid symptoms. 

Patients who received usual care without supplementation achieved a 50 per cent reduction in symptoms after about 6.7 days compared with 5.5 days for the Vitamin C group, 5.9 days for the zinc group, and 5.5 days for the group receiving both. 

There was no reduction in hospitalisations or deaths among the groups.

‘Research now catching up’

“When we began this trial, there was no research to support supplemental therapy for the prevention or treatment of patients with Covid-19,” Milind Desai, director of clinical operations at Cleveland Clinic’s Heart, Vascular & Thoracic Institute, said in a statement. 

“As we watched the pandemic spread across the globe, infecting and killing millions, the medical community and consumers alike scrambled to try supplements that they believed could possibly prevent infection, or ease COVID-19 symptoms, but the research is just now catching up,” Desai said.  

“We know that not all patients with Covid-19 require hospital admission, and compared to those being treated in a hospital setting, they are more likely to be seeking out supplements that could help them, so it was an important population to study,” said study co-author Suma Thomas, vice chair of strategic operations at the institute.


Also read: Why 50% Indians will be happy to have some Neanderthal DNA. Hint: It has to do with Covid


 

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Content of vitamins and minerals in the recommended daily dose – 1 tablet

(% of the recommended dietary allowance)

magnesium

56.25 mg

(15%)

Vitamin B6

1.4 mg

(100%)