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Can i use flonase everyday: Frequently Asked Questions About Our Products

by alexxlab

Frequently Asked Questions About Our Products

  • Can I use an HSA or FSA to buy Flonase?

    You can use your HSA and FSA tax-preferred savings account to purchase OTC products including Flonase. The passage of the CARES Act by Congress includes provisions to restore OTC eligibility under tax-preferred HSA and FSA accounts. Your plan details may vary, so save your receipt and check with your benefits or health provider for eligibility.

    Source: https://www.chpa.org/Monograph_FSA_CARES.aspx

  • What are FLONASE nasal sprays and how do they work?

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    VO:

    FLONASE nasal sprays are allergy relief medicines that work right in your nose to help block your allergic reaction at the source to relieve the symptoms that make you uncomfortable. FLONASE nasal sprays act on multiple inflammatory substances, including histamine, prostaglandins, cytokines, tryptases, chemokines and leukotrienes. Most common OTC allergy pills act only on histamine.* Because of the way it works, it may take several days for FLONASE nasal sprays to reach maximum effect. That’s why it’s best to use FLONASE nasal sprays once a day, every day, during allergy season. FLONASE nasal sprays not only relieve sneezing, itchy nose, runny nose and itchy, watery eyes**, but also relieve nasal congestion.

    FLONASE nasal sprays are allergy relief medicines that work directly in your nose to help target allergies at the source to relieve the symptoms that make you uncomfortable.

     

    FLONASE nasal sprays act on multiple inflammatory substances, including histamine, prostaglandins, cytokines, tryptases, chemokines and leukotrienes. Most allergy pills don’t finish the job because they don’t relieve nasal congestion†. FLONASE relieves the worst allergy symptoms, including nasal congestion, plus sneezing, itchy, watery eyes††, and runny nose.

     

    Because of the way it works, it may take several days for FLONASE nasal sprays to reach maximum effect. That’s why it’s best to use FLONASE nasal sprays once a day, every day, during allergy season.

     

    †vs single-ingredient antihistamines which do not treat nasal congestion

    †† Flonase Sensimist is indicated for itchy, watery eyes in adults and children 12 years of age and older.

  • What symptoms can FLONASE products relieve?

    FLONASE nasal sprays relieve a wide range of symptoms, providing 24-hour relief from nasal congestion, itchy eyes, watery eyes, runny nose, itchy nose, and sneezing.*

     

    FLONASE Headache & Allergy Relief caplets provide fast** relief for 4 to 6 hours against sinus congestion and pressure, nasal congestion, runny nose and sneezing, headache, and minor aches and pains. It also relieves symptoms, plus, it helps clear nasal passages, and to decongest sinus openings and passages.

     

    FLONASE Nighttime Allergy Relief tablets provide relief for up to 6 hours against runny nose, sneezing, itchy nose or throat and itchy, watery eyes due to hay fever or allergic rhinitis.

     

    *FLONASE SENSIMIST is indicated for itchy, watery eyes in Adults and Children 12 years if age and older. See product pages for full information.

    ** Symptom relief in 30 minutes.

  • How often do I need to take FLONASE products?

    In order to continue experiencing 24-hour symptom relief, be sure to take your FLONASE nasal spray once a day, every day, during allergy season.

     

    For FLONASE Headache & Allergy Relief caplets, it’s recommended that you take 2 caplets every 4 to 6 hours. Do not exceed more than 10 caplets in 24 hours.
     

    For up to 6 hours relief at night, take 1 FLONASE Nighttime Allergy Relief tablet every 4 to 6 hours. Do not exceed 4 tablets (10 mg) in 24 hours.

    Use as directed.

  • What happens when you have allergies?

    Allergies start when allergens like pollen, pet dander, dust, or mold enter your body.

    When this happens, your body’s natural response is to release multiple inflammatory substances, in order to get rid of the allergens. But it’s these inflammatory substances that cause your allergy symptoms.

  • How does FLONASE SENSIMIST Allergy Relief differ from FLONASE nasal spray?

    FLONASE SENSIMIST and FLONASE Allergy Relief nasal sprays are both full prescription strength allergy medicines that provide 24-hour relief from your allergy symptoms.

     

    Most allergy pills don’t finish the job because they don’t relieve nasal congestion†. FLONASE relieves the worst allergy symptoms, including nasal congestion, plus sneezing, itchy, watery eyes††, and runny nose.

     

    The main difference with FLONASE SENSIMIST nasal spray is that its patented MistPro Technology delivers a fine gentle mist. There is virtually no-drip, it’s scent-free, features an ergonomically designed bottle with the shortest nozzle of any allergy spray and is alcohol free.

     

    FLONASE Allergy Relief nasal spray, on the other hand, has been prescribed for millions and has built a loyal following over 20 plus years.

     

    † vs single-ingredient antihistamines which do not treat nasal congestion

    †† Flonase Sensimist is indicated for itchy, watery eyes in adults and children 12 years of age and older.

  • How does Children’s FLONASE SENSIMIST Allergy Relief differ from Children’s FLONASE Allergy Relief nasal spray?

      Both products contain the same type of allergy medicine and work the same way to relieve allergy symptoms.

    • Both allergy relief products provide more complete allergy symptom relief. *
    • Both help block 6 key allergic substances, not just 1.**
    • Both provide 24-hour relief.
    • Both provide 60 sprays per bottle.

     

    The important difference between the two products is that Children’s FLONASE SENSIMIST nasal spray offers a different sensory experience so you can pick the product you prefer for your child. The Children’s FLONASE SENSIMIST nasal spray pump is on the side of the bottle and is squeezed to produce a fine, gentle mist, that is alcohol-free, scent-free and is virtually drip-free.

     

    *Vs single-ingredient antihistamines that do not treat nasal congestion.

     

    **Mechanism vs most over-the-counter (OTC) allergy pills. FLONASE nasal sprays act on multiple inflammatory substances (histamine, prostaglandins, cytokines, tryptases, chemokines, and leukotrienes). The exact number and precise mechanism are unknown.

  • Do FLONASE products cause drowsiness?

    FLONASE nasal sprays do not cause drowsiness. However, drowsiness may occur when taking FLONASE Headache & Allergy Relief caplets or FLONASE Nighttime Relief tablets.

  • Are FLONASE nasal sprays habit-forming?

    FLONASE nasal sprays are non habit-forming and are safe to use every day as directed. FLONASE nasal sprays provide 24-hour, all-day and all-night relief from nasal congestion, itchy eyes, watery eyes,* runny nose, itchy nose, and sneezing

    * FLONASE SENSIMIST is indicated for itchy, watery eyes in adults and children 12 years if age and older. See product pages for full information.

  • What if little or nothing sprays out?

    Try priming your bottle. It may take a few pumps to get the dispenser spraying again. If that doesn’t work, the spray nozzle may be clogged. You can clean it following the directions in the Quick Start Guide that came in the package, or by watching the video here.

Frequently Asked Questions About Flonase Products

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    VO:

    Did you know that Flonase allergy relief is the first and only allergy nasal spray that is indicated for both nose and eye related allergy symptoms? Only Flonase is indicated to help relieve itchy watery eyes

    FLONASE is the first allergy nasal spray that is indicated for both nose- and eye-related allergy symptoms. FLONASE helps relieve itchy and watery eyes.

  • Read TranscriptHide Transcript

    VO:

    Did you know that Flonase allergy relief is the first and only allergy nasal spray that is indicated for both nose and eye related allergy symptoms? Only Flonase is indicated to help relieve itchy watery eyes

    FLONASE is for the treatment of allergy-related symptoms. If you feel severe pain in your face, have thick nasal discharge, or think you may have a sinus infection, stop using FLONASE and see your doctor. Your doctor may want to consider if other medicines are needed.

  • Read TranscriptHide Transcript

    VO:

    Flonase allergy relief helps relieve a broad range of symptoms for mini-indoor and outdoor allergens.

    ON SCREEN SUPER:

    Flonase helps with outdoor allergens such as weed pollen, Grass Pollen, tree pollen and mold spores. It also helps with indoor allergens such as pet dander, dust mites and mold.

    FLONASE helps relieve a broad range of symptoms from many allergens. FLONASE helps with outdoor allergens such as weed pollen, grass pollen, tree pollen, and mold spores. It also helps with indoor allergens such as pet dander, dust mites, and mold.

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    How does Flonase allergy relief work? Flonase is a nasal spray that works directly in your nose to relieve nose and eye related allergy symptoms. Flonase is minnably absorbed by the body and contains fluticasone propionate. The number one most prescribed allergy medicine for years and now it’s available over-the-counter

    FLONASE Allergy Relief is a nasal spray that works directly in the nose to relieve nose- and eye-related allergy symptoms. FLONASE contains fluticasone propionate—which for years has been the #1-prescribed allergy ingredient.*.

    As a nasal spray now available over the counter, FLONASE Allergy Relief works right in the nose, and is minimally absorbed by the body.1

    1. Sastre J, Mosges R. Local and systemic safety of intranasal corticosteroids. J Investig Allergol Clin Immunol. 22.1 (2012): n. pag. Web. 13 Oct. 2016. http://www.jiaci.org/issues/vol22issue1/1.pdf

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    VO:

    Female Speaker: How does Flonase Allergy Relief compare to other nasal sprays? Flonase is the first and only allergy nasal spray that is indicated for both nose and eye related allergy symptoms. Unlike some decongestant nasal sprays which cannot be used for more than three days, Flonase can be used every day and provide sustained 24 hours symptom relief.

    FLONASE is the first allergy nasal spray that is indicated for both nose- and eye-related allergy symptoms, blocking 6 of the allergic responses your body has to allergies.*

    Unlike some decongestant nasal sprays, which cannot be used for more than 3 days, FLONASE Allergy Relief can be used every day and provides sustained 24-hour symptom relief.1,2

    *Mechanism vs most OTC allergy pills. FLONASE nasal sprays acts on multiple inflammatory substances (histamine, prostaglandins, cytokines, tryptases, chemokines, and leukotrienes). The exact number and precise mechanism are unknown.

    1. GlaxoSmithKline. Data on file. 2013.

    2. Oxymetazoline HCl-menthol nasal. WebMD website. http://www.webmd.com/drugs/2/drug-20236/oxymetazoline-menthol-nasal/details

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    VO:

    Male Speaker: Many people ask if they can use Flonase allergy relief year-round. If you were 12 or older have been using Flonase steadily for 6 months you should check with your doctor before continuing to use Flonase on a daily basis. It is important to realize that the growth rate of some children may be slower while using this product. Children should use this in the shortest amount of time necessary to achieve symptom relief and talk to your child’s doctor if your child should use this spray for longer than two months a year. Children between the ages of 4 and 11 should use 1 spray in each nostril once every day under the supervision of an adult

    If you are 12 years old or older and have been using FLONASE steadily for 6 months, check with your doctor before continuing to use FLONASE on a daily basis.

    For users aged 4 to 11, talk to your doctor about continuing to take FLONASE after 2 months of daily use.

    The growth rate of some children may be slower while using this product. Children should use for the shortest amount of time necessary to achieve symptom relief.

  • Read TranscriptHide Transcript

    VO:

    Male Speaker: Many people are eager to understand how Flonase allergy relief is different. Unlike antihistamine medication Flonase helps block six allergic substances not just one you see antihistamines work by blocking the effect of histamine which is only one of the key chemicals released in the inflammatory Cascade and here’s another difference unlike allergy pills to travel through your body before providing released is a nasal spray that works directly at the source in the nose where you need it most.

    FLONASE helps block 6 of the key allergic responses your body has to allergies while antihistamines help block 1 of the responses.*

    Antihistamines work by blocking the effects of histamine, which is only 1 of the 6 key chemicals released in the inflammatory cascade.

    FLONASE is a nasal spray that works directly at the source—in the nose, where you need it most.

    *Mechanism vs most OTC allergy pills. FLONASE nasal sprays act on multiple inflammatory substances (histamine, prostaglandins, cytokines, tryptases, chemokines, and leukotrienes). The exact number and precise mechanism are unknown.

  • Read TranscriptHide Transcript

    VO:

    Male Speaker: Flonase allergy relief is just as strong as prescription Flonase. In fact, the medicine you now get over the counter, is exactly the same medicine in prescription Flonase. It’s the same medicine at the same strength and dose

    Yes. FLONASE Allergy Relief is exactly the same as prescription FLONASE—it’s the same medicine at the same strength and dose.

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    VO:

    Female Speaker: Your ability to get insurance coverage for Flonase allergy relief depends on the nature of your coverage. You may be able to use your flexible spending account to pay for Flonase. Insurance coverage may vary, and you should contact your insurance provider for more information.

    Depending on the nature of your coverage, you may be able to use your Flexible Spending Account to pay for FLONASE. Insurance coverage may vary and patients should contact their insurance provider for information.

  • Users 12 years of age and older

    Dosage

    Up to 2 sprays to each nostril daily

    Duration before checking with a doctor

    Up to 6 months of daily use

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    VO:

    Male Speaker: Sometimes people wonder if they should stop using Flonase allergy relief if their symptoms go away and it’s understandable that you may be tempted to stop using Flonase when you start to feel better. But it is important to keep using Flonase everyday as long as allergens may continue to bother you like pollen, mold dust or pet dander so you can continue to enjoy relief from your symptoms

    You may be tempted to stop using FLONASE when you start to feel better. It is important to keep using FLONASE daily as long as allergens bother you, like pollen, mold, dust, or pet dander—so you’ll continue to enjoy relief from your symptoms.

  • You should tell your doctor about all of the medicines you take, including FLONASE.

    FLONASE is not indicated for use with other nasal allergy medicines, but can be used with most other types of

    non-prescription and prescription medicines. However, there are a few medicines to look out for because they may cause the level of FLONASE in your body to become too high. Just to be safe, check this table:

    If You Are Taking
    Here’s What to Do

    Medicine for HIV infection (such as ritonavir)

    Talk to your doctor or pharmacist before using FLONASE Allergy Relief
    Medicines with glucocorticoids including some medicines for skin rash such as eczema, asthma, inflammation, allergy reactions, or eye conditions
    Talk to your doctor or pharmacist before using FLONASE Allergy Relief
    Ketoconazole pils for fungal infection
    Talk to your doctor or pharmacist before using FLONASE Allergy Relief

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    VO:

    Female Speaker: When you start using Flonase allergy relief no other allergy medicines are needed for your symptom’s relief. Flonase is not indicated for use with other allergy medicines. A combination of Flonase with an antihistamine has not been shown to be any more effective than Flonase alone.

    When using FLONASE, no other allergy medicines are needed for symptom relief. FLONASE is not indicated for use with other allergy medicines. A combination of FLONASE with an antihistamine has not been shown to be more effective than FLONASE alone.1

    1. GlaxoSmithKline. Data on file. 2013.

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    VO:

    Female Speaker: Current Medical guidelines for treating nasal allergies are based on the experience of millions of people who have used it to help relieve allergies. The medicine in Flonase Allergy relief, Fluticasone Propionate, has been the most prescribed allergy medicines for over 20 years.

    Millions of people have used FLONASE to help relieve allergies. The medicine in FLONASE, fluticasone propionate, has been the most prescribed allergy medicine in the world for over 20 years.

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    VO:

    Female Speaker: What dosing instructions and restrictions should children follow with Flonase allergy relief? Children between the ages of 4 and 11 should use one spray in each nostril once every day under the supervision of an adult. It’s important to realize that the growth rate of some children may be slower while using this product. Children should use it for the shortest amount of time next and you should talk to your child’s doctor if your child needs to use the spray for longer than 2 months a year.

    In their first week, children between the ages of 4 and 11 should use 1 spray in each nostril every day.

    The growth rate of some children may be slower while using this product. Children should use for the shortest amount of time necessary to achieve symptom relief.

    Talk to your child’s doctor if your child needs to use the spray for longer than 2 months a year.

    Children 4-11 years of age

    Children under 4 years of age

    Dosage

    1 spray in each nostril once daily

    Do not use.

    Duration before checking with a doctor

    Up to 2 months of use a year

    Do not use.

  • Read TranscriptHide Transcript

    VO:

    Flonase allergy relief helps relieve a broad range of symptoms for mini-indoor and outdoor allergens.

    ON SCREEN SUPER:

    Flonase helps with outdoor allergens such as weed pollen, Grass Pollen, tree pollen and mold spores. It also helps with indoor allergens such as pet dander, dust mites and mold.

    Serious side effects are rare with FLONASE. However, like all medicines, FLONASE can cause side effects in some people.

    Below are some side effects that have been reported with FLONASE. If you have any concerns about side effects, talk with your doctor.

    Side effects

    What Could Happen

    What to do

    Allergic reaction to the product

    • Sudden swelling of the face or tongue
    • A rash
    • Wheezing or feeling faint

    If you feel any of the symptoms, stop using FLONASE Allergy Relief and see a doctor right away.

    Nose injury

    • Severe or frequent nosebleed
    Apply pressure to the nose. Stop using FLONASE Allergy Relief and see a doctor right away.
    • Constant whistling sound that does not go away
    This could be a sign of damage to your nose. Stop using FLONASE Allergy Relief and see a doctor right away.

    Eye conditions such as cataracts or glaucoma

    • Cloudy vision
    • Reduced vision

    Schedule a yearly eye exam to check for these conditions. Read the Drug Fracts on the back of the FLONASE Allergy Relief Package for more details.

    Growth effects

    • Slower growth rate in some children while using product
    Talk to your child’s doctor if you are concerned or if your child is between 2 and 11 years of age and needs to use FLONASE Allergy Relief for longer than 2 months a year.

    Other side effects

    • Headaches or sneezing
    • Minor nosebleeds
    • Dry or irritated nose or throat
    Talk to your doctor or pharmacist if you are concerned.

  • Read TranscriptHide Transcript

    VO:

    Male Speaker: When it comes to sinus pain and pressure it’s important to consider your symptoms Flonase allergy relief is for the treatment of allergy related symptoms. If you feel severe pain in your face, have thick nasal discharge or think you may have a sinus infection you should stop using Flonase and see your doctor. Your doctor may want to consider if other medicines are needed

    If you miss a dose, just use your regular dose the next day. Don’t add an extra dose to make up for it.

  • Some people should not use FLONASE, or need to check with a health professional first.

    The following people should not use FLONASE Allergy Relief or should check with a healthcare professional:

    If You

    Here’s What to Do
    Are younger than 4
    Do not use FLONASE Allergy Relief.
    Are pregnant or breast-feeding
    Talk to a healthcare professional before using FLONASE Allergy Relief.
    Have or had glaucoma or cataracts
    Talk to your doctor before using FLONASE Allergy Relief.
    Have an injury or surgery to your nose that is not fully healed
    Do not use FLONASE Allergy Relief.
    Have ever had an allergic reaction to FLONASE or any of its ingredients
    Do not use FLONASE Allergy Relief.
    Are taking medicines for HIV infection (such as ritonavir)
    Talk to your doctor or pharmacist before using FLONASE Allergy Relief.
    Are taking ketoconazole pills (medicine for fungal infection)
    Talk to your doctor or pharmacist before using FLONASE Allergy Relief.
    Are using a steroid medicine for asthma, allergies, skin rash, allergic reactions, inflammation, or eye conditions
    Talk to your doctor or pharmacist before using FLONASE Allergy Relief.

instructions for use, price, analogues, composition, indications

Active ingredient: fluticasone propionate (micronized) 50.0 mcg/dose. Excipients: dextrose (anhydrous), Avicel RC591 (microcrystalline cellulose, sodium carboxymethylcellulose), phenylethanol, benzalkonium chloride (in the form of benzalkonium chloride solution), polysorbate 80, diluted hydrochloric acid, purified water.

White, opaque suspension, free from foreign particles.

Mechanism of action

After intranasal administration of fluticasone propionate, there is no or slight depression of the hypothalamic-pituitary-adrenal system.

No significant change in daily area under the pharmacokinetic curve of serum cortisol was observed after intranasal administration of fluticasone propionate at a dose of 200 mcg/day compared with placebo (ratio: 1.01; 90% confidence interval (CI) from 0.9 to 1. 14 ).

In a one-year, randomized, double-blind, placebo-controlled growth study in prepubertal children (ages 3-9years) in parallel groups (56 patients received intranasal fluticasone propionate and 52 patients received placebo), there was no statistically significant difference in growth rate between patients receiving intranasal fluticasone propionate (200 μg / day) and patients receiving placebo. Estimated growth rate over one year of treatment

was 6.20 cm/year (standard error (SD) = 0.23) in the placebo group and 5.99 cm/year (SD = 0.23) in the fluticasone propionate group; the mean difference between the groups • in terms of growth rate after one year was 0.20 cm/yr (SD = 0.28.95% CI -0.3‘5 to

0.76). There was no evidence of clinically significant changes in the function of the hypothalamic-pituitary-adrenal axis or bone mineral density based on assessment of 12-hour urinary cortisol excretion and dual-energy x-ray absorptiometry, respectively.

Absorption

After intranasal administration of fluticasone propionate at a dose of 200 mcg/day. maximum equilibrium plasma concentrations are not quantified in most patients (less than 0.01 ng / ml). The highest plasma concentration was recorded at 0.017 ng/mL. Direct absorption from the nasal cavity is unlikely due to low water solubility and ingestion of most of the drug. Absolute oral bioavailability is low (less than 1%) as a result of a combination of incomplete absorption from the gastrointestinal tract and active first-pass metabolism. The total systemic absorption is thus extremely low.

Distribution

Fluticasone propionate has a large volume of distribution at steady state (approximately 318 L). Communication with blood plasma proteins is moderately high (91%). Metabolism

Fluticasone propionate is rapidly eliminated from the systemic circulation, predominantly by metabolism in the liver to form an inactive carboxylic acid via the CYP3A4 isoenzyme of the cytochrome P450 system. The metabolism of the swallowed fraction of fluticasone propionate during the first passage through the liver occurs in the same way. Caution should be exercised when co-administering potent CYP3A4 inhibitors such as ketoconazole and ritonavir as there is a potential for increased systemic exposure to fluticasone propionate.

Excretion

Excretion of intravenous fluticasone propionate is linear in the dose range from 250 to 1000 mcg and is characterized by a high plasma clearance value (1.1 l / min). The maximum plasma concentration decreases by approximately 98% within 3-4 hours, and only at very low plasma concentrations was a terminal half-life of 7.8 hours observed. The renal clearance of fluticasone propionate is insignificant (less than 0.2%), and the inactive metabolite – carboxylic acid

– less than 5%. Fluticasone propionate and its metabolites are mainly excreted in the bile through the intestines. ..

Prevention and treatment of seasonal allergic rhinitis (including hay fever) and perennial rhinitis. Fluticasone propionate has a powerful anti-inflammatory activity, however, when applied topically to the nasal mucosa, it does not show a systemic effect.

Hypersensitivity to fluticasone propionate or any other component of the formulation.

There is insufficient evidence for the safety of use in pregnant women. Administration of corticosteroids to animals during pregnancy may result in fetal abnormalities, including cleft palate and intrauterine growth retardation. Therefore, there may be a small risk of developing such effects in the human fetus. However, it is worth noting that fetal changes in animals occurred after relatively high systemic exposure; direct intranasal administration provides minimal systemic exposure.

As with other medicines, the use of Flixonase® in pregnant women is possible only in cases where the expected benefit to the patient outweighs the possible risk to the fetus or child.

The secretion of fluticasone propionate into breast milk has not been studied. Subcutaneous administration of fluticasone propionate to lactating laboratory rats resulted in measurable plasma levels and fluticasone propionate in milk. However, after intranasal administration to primates, the drug was not detected in plasma and therefore it is unlikely that it will be detected in breast milk. For lactating women, Flixonase® can be prescribed only in cases where the expected benefit to the patient outweighs any possible risk to the child. 9allergic rhinitis, 2 injections in each nostril 1 time per day, preferably in the morning (200 mcg per day). In some cases, 2 sprays in each nostril 2 times a day (400 micrograms per day) can be used for a short time in order to achieve control of symptoms, after which the dose can be reduced. When symptoms return, the dose may be increased again. The lowest dose should be used to effectively control the symptoms of the disease. The maximum daily dose is 400 mcg (no more than 4 injections in each nostril).

The adverse events presented below are listed depending on the anatomical and physiological classification and frequency of occurrence. The frequency of occurrence is defined as follows: very often (£ 1/10), often (> 1/100 and As with other nasal sprays, there have been reports of sensations of unpleasant taste and smell, as well as headache.

As with other nasal sprays, dryness and irritation of the nose and throat, as well as epistaxis, have been reported. Also, after the use of intranasal corticosteroids, perforation of the nasal septum has been reported.

Systemic effects of some intranasal corticosteroids may occur; in particular, when used in high doses for a long period of time.

There is no evidence of acute or chronic overdose of fluticasone propionate.

In healthy volunteers, intranasal administration of 2 mg of fluticasone propionate twice a day for 7 days did not affect the function of the hypothalamic-pituitary-adrenal system.

The use of high doses of oral or inhaled corticosteroids over a long period of time may lead to depression of the function of the hypothalamic-pituitary-adrenal system.

The use of the drug in doses higher than recommended for a long period of time may lead to temporary inhibition of adrenal function.

In such patients, treatment with fluticasone propionate should be continued at doses necessary to control symptoms.

Under normal conditions, intranasal administration of fluticasone propionate results in very low plasma fluticasone propionate concentrations due to significant first-pass hepatic metabolism and high systemic clearance via cytochrome P450 3A4 in the intestine and liver. Therefore, clinically significant interactions with fluticasone propionate are unlikely. As shown in an interaction study in healthy volunteers, ritonavir (a strong inhibitor of the coenzyme CYP3A4 of the cytochrome P450 enzyme system) at a dose of 100 mg 2 times a day is able to significantly (several hundred times) increase plasma concentrations of fluticasone propionate, resulting in a sharp decrease in levels serum cortisol and systemic side effects have been noted, including Cushing’s syndrome and adrenal suppression. Such a combination should be avoided until the benefit of the appointment outweighs the possible risk of developing systemic glucocorticoid adverse reactions.

In a small study of inhaled fluticasone propionate in healthy volunteers, the slightly less potent CYP3A4 inhibitor ketoconazole was shown to increase fluticasone propionate exposure by 150% after a single inhalation. This results in a greater reduction in plasma cortisol compared to fluticasone propionate alone. It is expected that the co-administration of other strong inhibitors of the CYP3A4 coenzyme of the cytochrome P450 enzyme system, such as itraconazole, will also lead to an increase in the systemic exposure of fluticasone propionate and the risk of developing systemic side effects.

Caution is advised to avoid, if possible, long-term therapy with such drugs. I__

Studies have shown that other inhibitors of the CYP3A4 isoenzyme of the cytochrome P450 system cause a negligible (erythromycin) or insignificant (ketoconazole) increase in plasma fluticasone propionate concentration, which does not entail any noticeable decrease in serum cortisol concentration. However, caution should be exercised in the combined use of inhibitors of the CYP3A4 isoenzyme of the cytochrome P450 enzyme system (for example, ketoconazole) and fluticasone propionate due to a possible increase in the plasma concentration of the latter.

Elderly patients Usual adult dose.

Children under 12 years old

For the prevention and treatment of seasonal and perennial allergic rhinitis in children aged 4-11 years, the drug is prescribed 1 injection (50 mcg) in each nostril 1 time per day, preferably in the morning. In some cases, it may be necessary to prescribe 1 injection in each nostril 2 times a day. The maximum daily dose is 200 mcg (no more than 2 injections in each nostril). The lowest dose should be used to effectively control the symptoms of the disease.

Using the inhaler

Before use, gently shake the bottle, take it by placing your index and middle fingers on either side of the tip, and your thumb under the bottom.

When using the drug for the first time or after a break in its use for more than 1 week, check the nebulizer for proper operation: direct the tip away from you, make several pressures until a small cloud appears from the tip. Next, you need to clear your nose (blow your nose). Close one nostril and insert the tip into the other nostril. Tilt your head slightly forward while continuing to hold the vial upright. Then you should begin to inhale through the nose and, continuing to inhale, make a single press with your fingers to spray the drug. Exhale through your mouth. Repeat the procedure for a second spray in the same nostril, if necessary. Then completely repeat the described procedure by inserting the tip into the other nostril. After use, blot the tip with a clean tissue or handkerchief and close it with a cap.

Sprayer should be flushed at least once a week. To do this, carefully remove the tip and rinse it in warm water. Shake off excess water and leave

to dry in a warm place. Avoid overheating. Then carefully place the tip back into place at the top of the vial. Put on the protective cap.

If the orifice of the handpiece is clogged, the handpiece should be removed as described above and left for a while in warm water. Then rinse under running cold water, dry and put back on the bottle. Do not clean the tip hole with a pin or other sharp objects.

Local infections; nasal tract infections should be treated appropriately, but they are not a contraindication for Flixonase® therapy.

The full effect of fluticasone propionate nasal spray may not be seen until several days of treatment.

Caution should be exercised when transferring patients from systemic glucocorticosteroid therapy to fluticasone propionate nasal spray treatment if there is reason to suspect adrenal dysfunction.

In most patients, fluticasone propionate nasal spray relieves the symptoms of seasonal allergic rhinitis, but in some cases, with very high concentrations of allergens in the air, additional therapy may be necessary. Systemic effects of nasal corticosteroids can be observed mainly with the appointment of high doses for a long time. These effects are much less common than with oral corticosteroids and may vary from patient to patient and between different corticosteroid drugs (see Pharmacodynamics and Pharmacokinetics). Potential systemic effects may include Cushing’s syndrome, Cushingoid traits, adrenal suppression, growth retardation in children and adolescents, cataracts, glaucoma, and, less commonly, physiological and behavioral reactions such as psychomotor hyperactivity, sleep disturbances, anxiety, depression, or aggression (especially in children). ).

Growth retardation has been reported in children receiving registered doses of certain nasal corticosteroids. It is recommended to regularly monitor the growth of children receiving long-term therapy with nasal corticosteroids. When growth is slowed, therapy should be reviewed, if possible, with the aim of reducing the dose to the minimum that effectively controls the symptoms of the disease. In addition, a visit to the pediatrician is recommended.

Therapy with higher than recommended doses of the drug may lead to clinically significant suppression of adrenal function. If higher than recommended doses are used, consideration should be given to the use of additional systemic corticosteroids during periods of stress or elective surgery.

Ritonavir may significantly increase plasma concentrations of fluticasone propionate. Therefore, concomitant use of ritonavir and fluticasone propionate should be avoided unless the potential benefit to the patient outweighs the potential risk of systemic side effects of corticosteroids. There is an increased risk of systemic side effects when fluticasone propionate is used in combination with other potent CYP3A inhibitors.

EFFECTS ON THE ABILITY TO DRIVE VEHICLES, MECHANISMS

There are no reports of the effect of the drug on the ability to drive vehicles and other mechanisms.

Dosed nasal spray 50 mcg/dose.

60 and 120 doses in Type I or Type III amber glass vials. Each vial is equipped with a dosing device. An adapter for intranasal administration is put on the vial and dosing device. The bottle is additionally equipped with a cap to protect the adapter from dust.

Each vial, together with a dosing device, an adapter and a protective cap (in the assembled state) and instructions for medical use, is placed in a cardboard box.

Store below 30°C.

Keep out of reach of children.

3 years.

Do not use after the expiry date which is stated on the packaging.

Prescription.

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