Can prozac make you lose weight: Changes in weight during a 1-year trial of fluoxetine

30.09.202308.07.2023 by alexxlab

Содержание

Changes in weight during a 1-year trial of fluoxetine

Clinical Trial

. 1999 Aug;156(8):1170-6.

doi: 10.1176/ajp.156.8.1170.

D Michelson¹, J D Amsterdam, F M Quitkin, F W Reimherr, J F Rosenbaum, J Zajecka, K L Sundell, Y Kim, C M Beasley Jr

Affiliations

Affiliation

¹ Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA. [email protected]

PMID:
10450256
DOI:
10.1176/ajp.156.8.1170

Clinical Trial

D Michelson et al.

Am J Psychiatry.

1999 Aug.

. 1999 Aug;156(8):1170-6.

doi: 10.1176/ajp.156.8.1170.

Authors

D Michelson¹, J D Amsterdam, F M Quitkin, F W Reimherr, J F Rosenbaum, J Zajecka, K L Sundell, Y Kim, C M Beasley Jr

Affiliation

¹ Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA. [email protected]

PMID:
10450256
DOI:
10.1176/ajp.156.8.1170

Abstract

Objective:

Fluoxetine has been associated with weight loss during acute treatment, but no controlled studies of weight change during long-term treatment with fluoxetine or other selective serotonin reuptake inhibitors have been reported. Weights were assessed for patients whose depressive symptoms had disappeared with acute fluoxetine treatment. Patients were then randomly assigned to continuation treatment with fluoxetine or placebo.

Method:

Patients whose illness had remitted after 12 weeks of treatment with fluoxetine, 20 mg/day, were randomly assigned to receive up to 38 weeks of treatment with fluoxetine or placebo. Weight was assessed at each visit. Change in weight was analyzed during the initial 12 weeks of acute treatment and after 14, 26, and 38 weeks. Relationships between weight change and body mass index and between weight change and appetite change were assessed.

Results:

During the initial 4 weeks of therapy, a mean absolute weight decrease of 0.4 kg was observed for all patients. Among patients who completed 50 weeks of therapy, the mean absolute weight increase during continuation treatment was similar for both the placebo- and fluoxetine-treated groups. Weight increase was not related to initial body mass index but was related to both poor appetite at study entry and to improvement in appetite after recovery. No patients discontinued therapy because of weight gain.

Conclusions:

Acute therapy with fluoxetine is associated with modest weight loss. After remission of depressive symptoms, weight gain for patients taking fluoxetine for longer periods is not different from that for patients taking placebo and is most likely related to recovery from depression.

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Does Prozac cause weight gain or loss?

Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on Feb 17, 2023.

Initially, you may lose a small amount of weight, about 1 kg (2.2 lb) on average, when you first start taking Prozac, but over the long-term you may gain that weight back or even add on extra weight up to 6 kgs (13.2 lbs). Studies suggest this may be due to a recovery of your appetite after your symptoms subside. Weight changes may vary between patients, but in general Prozac is not usually associated with serious weight gain (over 7%).

In Prozac studies, weight loss has been reported in about 2% of patients (2 out of every 100), but patient self-reports of weight gain have been much higher, up to 37% in one survey.

Selective serotonin reuptake inhibitors (SSRIs) available in the U.S. include:

Celexa (citalopram)

Lexapro (escitalopram)

Prozac (fluoxetine)

Fluvoxamine (generic only)

Paxil (paroxetine)

Zoloft (sertraline)

Of all of the SSRIs, Prozac (fluoxetine) appears to be associated with the least chance for weight gain and Paxil (paroxetine) with the greatest chance. Paroxetine has been shown to lead to up to a 3.6% weight gain in about 6% of patients in one study. Other antidepressants, such the tricyclic antidepressants (TCAs) or mirtazapine can be associated with significant weight gain.

Why do weight changes occur with Prozac?

Weight gain

It is not fully clear if longer-term weight gain with selective serotonin reuptake inhibitors (SSRIs) is due to a drug side effect, the recovery of appetite after symptom recovery, or a mix of both. Short-term Prozac treatment for up to 3 months usually leads to little weight change, but most patients need medication for longer periods. Other reasons for weight gain with SSRIs may include genetic differences and increased carbohydrate cravings.

Weight loss

Weight loss during early treatment with Prozac may also be due to stomach (gastrointestinal) side effects. All SSRIs can cause some degree of short-term nausea and digestive tract discomfort when starting therapy or increasing the dose.

Over time, these common side effects tend to improve for most patients, but can include:

loss of appetite (4% to 17% of patients)

diarrhea (8% to 18% of patients)

nausea (12% to 29% of patients)

Patients with diabetes may have trouble with low blood sugar levels while taking Prozac, but blood sugar levels may increase when treatment is stopped. Your healthcare provider may need to adjust your dose of diabetes medications.

Other common side effects with SSRIs include sexual dysfunction, insomnia, headache, dry mouth, sedation, sweating, tremor, agitation and orthostatic hypotension (low blood pressure, dizziness when standing). Serious side effects like suicidal thoughts, bleeding, abnormal heart rhythms can also occur with SSRIs.

Studies: Weight Changes with Prozac

In studies looking at weight changes with Prozac (fluoxetine), weight loss has ranged from about 0.2% of body weight to a gain of about 1%.

Study 1

In a one-year randomized study, patients whose depressive symptoms had subsided after 12 weeks of treatment with fluoxetine 20 mg/day received either fluoxetine or a placebo (an inactive treatment) for 38 weeks. Weight changes were assessed during the initial 12 weeks of treatment and after 14, 26, and 38 weeks (for a total of 50 weeks).

During the initial 4 weeks of treatment, an average weight decrease of 0.4 kg (0.9 lb) was observed for all patients. After 50 weeks, weight increases were similar between the Prozac and placebo-treated groups. An average weight gain of 3 kg (6.6 lb) was observed over the entire 50-week period in the fluoxetine group, compared to 3.2 kg (7 lb) for the placebo group.

Weight gain was associated with a poor appetite at the beginning of treatment and an improved appetite after depressive symptoms cleared. Weight gain was not associated with the patient’s body weight at the start of the study.

No patients stopped Prozac treatment due to weight gain.

Study 2

In another study in 284 patients with major depressive disorder, long-term weight changes with Prozac were assessed when compared to paroxetine (Paxil) or sertraline (Zoloft), other commonly used SSRIs. Patients were evaluated for a total of 26 to 32 weeks.

Researchers looked at the average change in weight in each group and the number of patients with at least a 7% increase in weight from the start of the study.

Patients treated with paroxetine (Paxil) had a significant increase in weight, and those with a 7% or greater weight increase were highest in this group. Patients receiving fluoxetine (Prozac) or sertraline (Zoloft) had a modest but nonsignificant weight increase.

Bottom Line

Prozac is associated with a low amount of weight gain over the long- term compared to many SSRIs. Early in treatment, during the first few weeks it can cause a slight weight loss, but usually only about a pound or so.

It appears weight loss may be due to adverse stomach side effects like nausea or loss of appetite in the short-term, while weight gain may occur over the longer-term due to improved appetite and social functioning with improved mood.

If you are concerned about weight gain or loss with any antidepressant treatment, speak with your healthcare provider. There are many options to treat depression, some that have fewer side effects like weight gain. Do not stop treatment on your own without speaking to your healthcare provider.

This is not all the information you need to know about Prozac (fluoxetine) for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.

References

Michelson D, Amsterdam JD, Quitkin FM, et al. Changes in weight during a 1-year trial of fluoxetine. Am J Psychiatry. 1999 Aug;156(8):1170-6. doi: 10.1176/ajp.156.8.1170.

Fava M, Judge R, Hoog SL, et al. Fluoxetine versus sertraline and paroxetine in major depressive disorder: changes in weight with long-term treatment. J Clin Psychiatry. 2000 Nov;61(11):863-7. doi: 10.4088/jcp.v61n1109.

Serretti A, Mandelli L. Antidepressants and body weight: a comprehensive review and meta-analysis. J Clin Psychiatry. 2010 Oct;71(10):1259-72. doi: 10.4088/JCP. 09r05346blu.

Anagha K, Shihabudheen P, Uvais NA. Side Effect Profiles of Selective Serotonin Reuptake Inhibitors: A Cross-Sectional Study in a Naturalistic Setting. Prim Care Companion CNS Disord. 2021 Jul 29;23(4):20m02747. doi: 10.4088/PCC.20m02747.

Hirsch M (author). Selective serotonin reuptake inhibitors: Pharmacology, administration, and side effects. Up to Date. https://www.uptodate.com/contents/selective-serotonin-reuptake-inhibitors-pharmacology-administration-and-side-effects

Prozac Weekly. Professional. Prescribing information. Accessed Dec. 8, 2022 at https://www.drugs.com/pro/prozac-weekly.html#s-42231-1

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Medical Disclaimer

3 terrible ways that anorexic women use

Anorexia nervosa is a serious disease that is difficult to treat. At the same time, a huge number of girls tend to get sick with them. Only the network public “40 kg” has more than 5 million subscribers, hundreds of thousands more have publics “Typical anorexic”, “Ana loves you” and the like. In search engines, along with the word “anorexia”, they often look for the phrase “how to get sick.” Get sick and lose weight. Sometimes to death. We learned all about 3 scary ways that girls who dream of becoming “fragile butterflies” lose weight.

Tags:

healthy eating

Anorexia

Do not do that

Nutritional supplements

Dangerous weight loss

Getty images

Preparations

Do not self-medicate! In our articles, we collect the latest scientific data and the opinions of authoritative health experts. But remember: only a doctor can diagnose and prescribe treatment.

Reduxin

In any pharmacy, you can safely buy Reduxin-Light – this is not a medicine, but a dietary supplement (BAA), the main active component of which is linoleic acid. A completely different matter is the drug “Reduxin”. This is a prescription drug. The active substance is sibutramine, an anorexigenic drug. The drug artificially causes a feeling of fullness, due to which the patient, suffering from obesity, ceases to exceed the daily calorie intake. True, sibutramine can only be used in complex therapy, under the constant supervision of a doctor, and if other methods of combating obesity have not worked, and the patient has a high risk of developing diseases associated with overweight. Anorexics, of course, do not have obesity, but there is a lack of body weight. And this body, already weakened, is forced to fight the side effects of sibutramine.

In the countries of the European Community, the use of sibutramine was suspended in 2010, when the European Medicines Agency published the results of studies on the risks of side effects of the drug: the drug should not be taken by patients who have ever had diseases of the cardiovascular system – it can cause tachycardia, atrial fibrillation, increased blood pressure, as well as convulsions, dizziness, dysmenorrhea, and more than 20 side effects.

ADVERTISING – CONTINUED BELOW

Motivator from the 40 kg community

Fluoxetine

Aka Prozac. This is not a weight loss drug, but a strong antidepressant, one of the side effects of which is loss of appetite. A person suffering from depression, when taking fluoxetine, will notice an improvement in mood, a decrease in anxiety and fear, and normalization of sleep. A pronounced effect will appear after a week of taking the drug. In the event that fluoxetine is suitable for the patient. If not, then the impressive list of side effects of taking fluoxetine is not at all the worst thing. At one time, the pharmaceutical company that produced Prozac hid the fact that more than 2,000 people committed suicide while taking fluoxetine drugs. Despite the fact that before that, suicidal thoughts did not bother them, despite depression.

ECA

Infernal cocktail: ephedrine, caffeine, aspirin. Ephedrine is a psychoactive poisonous alkaloid, a raw material for the production of drugs containing methamphetamine and ephedron. The storage, use and sale of ephedrine in Russia is prohibited, but this fact does not stop anorexics. It is impossible to find ephedrine in its pure form, but ephedrine-containing drugs are easy to find: for example, Broncholithin cough syrup. The standard composition of the cocktail is 25 mg of ephedrine, 250 caffeine and 250 aspirin. The girls take this mixture three times a day. Allegedly, it helps to burn fat at lightning speed. At the same time, naturally, it adversely affects the cardiovascular system.

Community motivator 40 kg

Laxatives and diuretics

The principle of action of these drugs is clear: the former help to empty the intestines, the latter have a diuretic effect – due to this, the illusion of weight loss is created. Naturally, neither the volume of muscle mass nor the volume of fat from taking these drugs does not change. But problems with the gastrointestinal tract begin from the constant use of laxatives. Diuretics, on the other hand, cannot be used at all without a doctor’s prescription: they remove potassium, calcium and magnesium ions from the body. It is very difficult to restore their balance without a doctor’s supervision and under the condition of a half-starved diet.

Diets

The most popular two-week anorexic diet contains almost no food at all: 6 apples and 2 cucumbers – this is the only solid food that is allowed to be eaten in 2 weeks!

1 day – green tea;
Day 2 – 4 cups of kefir;
Day 3 – 1 bottle of mineral water;
4th day – 1 apple;
Day 5 – 4 glasses of milk;
Day 6 – green tea;
Day 7 – 4 glasses of milk;
Day 8 – 2 apples;
9th day – a liter of kefir;
10 day – 2 cucumbers;
11 day – green tea;
12 day – a liter of milk;
Day 13 – 3 apples;
Day 14 – mineral water.

Community motivator 40 kg

On the so-called “drinking” diet, you can not eat solid food at all. Only liquid. 10 days. For the most persistent – 14.

Between diets, girls switch to “healthy food”: thin slices of whole grain bread, 20 grams of dark chocolate (99% cocoa), a pinch of oatmeal, seasoned with grated green apple for sweetness – the usual menu for the day.

Self-torture

Naturally, the body still tries to fight hunger, and girls, despite taking drugs, have “breakdowns”. What they call “gluttony”, but which in essence is an attempt to eat a normal portion of ordinary food – after all, after a long fast, eating more than a normal portion is problematic. It hurts.

Motivator from the “40 kg” community

And after failures always comes punishment. That is, self-torture. Posting your photos with the caption “I’m fat” in the sit down is the mildest possible punishment. You can also post a photo in an album for criticism and get a dose of insults. You can punish yourself with a dry fast. Dry means you can’t even drink. No food, no water.

When obsessive thoughts about food arise, anorexics are advised to imagine something terrible instead of food: worms, rotting corpses, or excrement. Do unpleasant things. Punish yourself with hard physical work.

And the last way – cuts. Anorexics cut themselves (mainly their legs, many then post photos of cuts on their thighs online). In fact, the problem of self-harm is not the problem of anorexia. Self-harm is an unhealthy attempt to eliminate emotional pain, intense anger and frustration. It can bring short-term relief both on an emotional and physical level: on the one hand, there is a feeling of control over one’s own body, on the other hand, the cut provides a surge of adrenaline, which, in turn, makes past experiences irrelevant. But not for long. Then again comes the feeling of guilt, shame and the return of previously experienced emotions.

Does fluoxetine really make you lose weight? Urgent need.

July 23, 2014 00:18

July 23, 2014 00:37

9 0120 July 23, 2014 00:59

July 23 2014 01:38

July 23, 2014 01:56

July 23, 2014 01:56 9 0109

July 23, 2014, 01:56

July 23, 2014 04:11

July 23, 2014 08:32 AM

#10

July 23, 2014, 09:09 am

#11

Guest

Hmm, it is prescribed for patients with anorexia, bulimia, depression. Can you lose weight from it? Hardly.

July 23, 2014, 09:18

#12

July 23, 2014, 09:29

#13

July 23, 2014, 09:51

#14

Guest

Guest 11, why? For the purpose of losing weight?

July 23, 2014 10:57 am

#15

July 23, 2014 12:28

#16

Katya

such drugs are addictive. learn to fight depression and overweight yourself. there are no magic pills, otherwise everyone would be happy and slim.

23 July 2014, 14:18

#17

mutka

plus

Katya

such drugs are addictive. learn to fight depression and overweight yourself. there are no magic pills, otherwise everyone would be happy and slim.

July 23, 2014 6:17 pm

#18

July 23, 2014 6:23 pm

#19

Misyusya

I have depression. Already treated three times. Now I’m rolling again. I took citalopram. Contains bromine. Calms down and I start to eat. I lost weight, but the kg returned. Therefore, I think, maybe ask the doctor to prescribe fluoxetine. I’m going to lose weight at the same time. there is nowhere to recover, the stomach does not go away. It’s disgusting to look at yourself.

July 23, 2014 6:39 PM

#20

July 24, 2014 12:38

#21

July 24, 2014 12:49 pm

#22

Guest

Hmm, it is prescribed for patients with anorexia, bulimia, depression. Can you lose weight from it? Hardly.

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July 24, 2014 03:13 PM

#23

July 24, 2014 08:01 PM

#24

Jul 24, 2014 9:38 PM

#25

Jul 24, 2014 9:39 PM

#26

Y awn

I also had depression, went to a psychiatrist and prescribed Prozac (just fluoxetine ) but people took a quarter of a tablet to him, and for some reason I didn’t lose a single gram, on the contrary, I ate from 54kg to 56-57!
But I felt so good, I went to bed at 21. 00 in the morning I woke up calm, my mood was normal, no bad emotions, though the good ones are not felt brightly!
in general will not help to lose weight!!!

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. This is a drug for diabetics yet, but it is also really prescribed for those who need to lose weight. He reduces the amount of insulin there and the arms and legs do not shake and there are no thoughts about food when you want to eat. I now eat 2 tablets a day of Glucophage 850. But I’m on a diet and this drug just helps me not to get nervous if an attack of hunger or longing for a tasty treat comes over

Feb 18, 2015 6:46 pm

#29

June 15, 2015 3:34 pm

#30

August 20, 2015, 07:12 PM

#31

Author

I am depressed! I’m going to go to the doctor to prescribe medicine. I read that fluoxetine is a good drug. Yes, and they lose weight from it. This is true? Who took and lost weight unsubscribe. I would appreciate that.

August 20, 2015 7:14 pm

#32

August 31, 2015, 21:37

#33

Guest

You may lose a couple of kilos, but you will quickly gain even more, fluoxitine has an unpleasant side effect, IT KILLS LIBIDO 90 003 December 17, 2015, 18:52

#34

Vera

Fluoxetine is a good drug and it really makes you lose weight.

#35

20 December 2015 11:56

#36

12 November 2016 06:23

#37

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13 November 2016 05:40

#39

March 15, 2017, 21:22

#40

August 23, 2017, 03:57

#41

I’m depressed! I’m going to go to the doctor to prescribe medicine. I read that fluoxetine is a good drug. Yes, and they lose weight from it. This is true? Who took and lost weight unsubscribe. I would appreciate that.

Oct 05, 2017 07:18

#42

Nov 17, 2017 07:34

#43

Y awn

I recently took it for weight loss, but given that I have a lot of weight, yes and I was on a diet, I still didn’t lose weight, as I stopped taking the weight went down

November 17, 2017, 07:41

#45

09 April 2018, 14:12 April 27, 2018 Can you lose weight from it? Hardly.

Can prozac make you lose weight: Changes in weight during a 1-year trial of fluoxetine

Changes in weight during a 1-year trial of fluoxetine

Affiliation

Authors

Affiliation

Abstract

Similar articles

Cited by

Publication types

MeSH terms

Substances

Does Prozac cause weight gain or loss?

Why do weight changes occur with Prozac?

Weight gain

Weight loss

Studies: Weight Changes with Prozac

Study 1

Study 2

Bottom Line

Related medical questions

Drug information

Related support groups

3 terrible ways that anorexic women use

Preparations

Reduxin

Motivator from the 40 kg community

Fluoxetine

ECA

Community motivator 40 kg

Laxatives and diuretics

Diets

Community motivator 40 kg

Self-torture

Motivator from the “40 kg” community

Does fluoxetine really make you lose weight? Urgent need.

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