Can you buy mefenamic acid over the counter. Mefenamic Acid: Uses, Dosage, and Availability for Pain Relief

18.09.202306.07.2023 by alexxlab

What is mefenamic acid used for. How does mefenamic acid work for pain relief. Can you buy mefenamic acid over the counter. What are the recommended dosages for mefenamic acid. What are potential side effects of taking mefenamic acid.

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Understanding Mefenamic Acid: A Powerful NSAID for Pain Management

Mefenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) commonly prescribed for managing various types of pain, particularly menstrual discomfort. This medication belongs to the same class as ibuprofen, naproxen, and celecoxib, working to reduce inflammation and alleviate pain in the body. While it’s a prescription medication in many countries, understanding its uses, dosage, and potential side effects is crucial for those considering or currently using this treatment.

What is Mefenamic Acid Used For?

Mefenamic acid is primarily used for:

Menstrual pain and cramps
Mild to moderate pain relief
Headaches
Dental pain
Arthritis pain in some cases

Its effectiveness in managing menstrual discomfort has made it a popular choice among women seeking relief from period-related pain.

The Mechanism of Action: How Mefenamic Acid Works

Mefenamic acid operates by inhibiting the production of prostaglandins in the body. Prostaglandins are hormone-like substances that play a role in pain and inflammation. By reducing prostaglandin levels, mefenamic acid helps to:

Decrease inflammation
Alleviate pain
Reduce fever

This mechanism is similar to other NSAIDs but mefenamic acid may have specific benefits for menstrual pain due to its particular effects on prostaglandin production in the uterus.

Availability and Prescription Requirements for Mefenamic Acid

Is mefenamic acid available over the counter? In most countries, including the United States and the UK, mefenamic acid is a prescription-only medication. This means you cannot buy it directly from a pharmacy without a doctor’s prescription. The prescription requirement is due to the potential side effects and drug interactions associated with its use.

How to Obtain Mefenamic Acid

To get mefenamic acid, you typically need to:

Consult with a healthcare provider
Discuss your symptoms and medical history
Receive a prescription if the doctor deems it appropriate
Fill the prescription at a pharmacy

Some online healthcare services may offer consultations and prescriptions for mefenamic acid, but it’s crucial to use reputable, licensed providers for such services.

Dosage Guidelines: Using Mefenamic Acid Safely and Effectively

The appropriate dosage of mefenamic acid can vary depending on the condition being treated and individual factors. However, some general guidelines include:

For menstrual pain: 500 mg as an initial dose, followed by 250 mg every 6 hours as needed
For other types of pain: 500 mg as an initial dose, followed by 250 mg every 6 hours

It’s crucial to follow your doctor’s instructions and not exceed the recommended dose. Mefenamic acid is typically taken with food to reduce the risk of stomach upset.

Duration of Treatment

Mefenamic acid is usually prescribed for short-term use, often not exceeding 7 days for most conditions. For menstrual pain, it’s typically used only during the menstrual period. Prolonged use increases the risk of side effects and should be avoided unless specifically directed by a healthcare provider.

Potential Side Effects and Precautions When Taking Mefenamic Acid

Like all medications, mefenamic acid can cause side effects. Common side effects may include:

Stomach upset or pain
Nausea
Diarrhea
Headache
Dizziness

More serious side effects, though rare, can include:

Gastrointestinal bleeding
Allergic reactions
Liver problems
Increased risk of heart attack or stroke (with long-term use)

It’s important to seek medical attention if you experience severe side effects or allergic reactions while taking mefenamic acid.

Precautions and Contraindications

Mefenamic acid may not be suitable for everyone. It should be used with caution or avoided in people with:

History of stomach ulcers or bleeding
Heart disease or high blood pressure
Kidney or liver problems
Asthma (especially if sensitive to aspirin)
Pregnancy, especially in the third trimester

Always inform your healthcare provider about any existing medical conditions or medications you’re taking before starting mefenamic acid.

Alternatives to Mefenamic Acid for Pain Management

While mefenamic acid can be effective for pain relief, particularly menstrual pain, there are several alternatives available:

Other NSAIDs like ibuprofen or naproxen
Acetaminophen (paracetamol)
Hormonal treatments for menstrual pain (e.g., birth control pills)
Non-pharmacological methods like heat therapy or exercise

The choice of alternative depends on the specific condition, individual health factors, and preferences. Consulting with a healthcare provider can help determine the most suitable option.

Interactions and Considerations: Using Mefenamic Acid Safely

Mefenamic acid can interact with various medications and substances. Some important interactions to be aware of include:

Other NSAIDs: Combining mefenamic acid with other NSAIDs can increase the risk of side effects
Anticoagulants: Mefenamic acid may increase the risk of bleeding when used with blood thinners
Antihypertensives: It may reduce the effectiveness of some blood pressure medications
Alcohol: Consuming alcohol while taking mefenamic acid can increase the risk of stomach irritation

Always inform your healthcare provider about all medications, supplements, and herbal products you’re using to avoid potential interactions.

Special Considerations for Different Age Groups

The use of mefenamic acid may require special consideration in certain age groups:

Elderly: May be more susceptible to side effects and may require lower doses
Children: Use in children should be carefully monitored and is often limited to specific conditions
Pregnant women: Generally avoided, especially in the third trimester due to potential risks to the fetus

These considerations highlight the importance of personalized medical advice when considering mefenamic acid use.

Long-term Use and Monitoring: Ensuring Safe and Effective Treatment

While mefenamic acid is primarily intended for short-term use, some individuals may require longer-term treatment. In such cases, regular monitoring is essential to ensure safety and effectiveness. This may involve:

Regular check-ups with a healthcare provider
Blood tests to monitor liver and kidney function
Assessments for gastrointestinal side effects
Evaluations of pain management efficacy

Long-term use of any NSAID, including mefenamic acid, should be carefully considered due to the potential for increased risks of cardiovascular and gastrointestinal complications.

Strategies for Minimizing Risks

To reduce the risks associated with mefenamic acid use, consider the following strategies:

Use the lowest effective dose for the shortest duration possible
Take the medication with food to reduce stomach irritation
Stay well-hydrated to support kidney function
Avoid alcohol consumption while taking the medication
Report any unusual symptoms to your healthcare provider promptly

These strategies can help ensure that the benefits of mefenamic acid outweigh the potential risks.

The Future of Pain Management: Mefenamic Acid and Beyond

As research in pain management continues to evolve, the role of medications like mefenamic acid is constantly being evaluated. Current trends and future directions in pain management include:

Development of more targeted NSAIDs with fewer side effects
Exploration of combination therapies for enhanced pain relief
Investigation of alternative delivery methods to reduce systemic exposure
Integration of non-pharmacological approaches with medication therapy

While mefenamic acid remains a valuable tool in pain management, particularly for menstrual pain, ongoing research may lead to even more effective and safer options in the future.

The Importance of Personalized Pain Management

As our understanding of pain mechanisms and individual variability grows, there’s an increasing emphasis on personalized approaches to pain management. This may involve:

Genetic testing to predict drug responsiveness and risk of side effects
Tailored treatment plans based on individual pain patterns and lifestyle factors
Integration of complementary therapies alongside conventional medications
Use of digital health tools for better pain tracking and management

These advancements underscore the importance of working closely with healthcare providers to develop the most effective pain management strategy for each individual.

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Mefenamic Acid – Overview

Mefenamic acid is a medication sometimes prescribed to people who need relief from mild pain, including menstrual pain. People who might need a mefenamic acid prescription can use Push Health to connect with a local medical provider who can prescribe mefenamic acid medication, including mefenamic acid 500 mg and mefenamic acid 250 mg tablets, when appropriate to do so.

Mefenamic Acid – Dosage and Cost

Mefenamic acid is sometimes marketed under the brand Ponstel and, like celecoxib (Celebrex), ibuprofen (Motrin), meloxicam (Mobic) and naproxen (Naprosyn), belongs to a class of medications known as nonsteroidal anti-inflammatory drugs (NSAIDs). Mefenamic acid can help bring relief from mild to moderate pain, including menstrual pain, and potentially other pain syndromes. It is not entirely clear how mefenamic acid exerts its actions but it may involve modulation of prostaglandins in the body. Mefenamic acid is sometimes prescribed with a loading dose of mefenamic acid 500 mg followed by mefenamic acid 250 mg at various times during the day, depending on the health needs of the patient. Mefenamic acid tablets are moderately affordable, costing approximately $4 per mefenamic acid tablet at many pharmacies in the United States. Mefenamic acid coupons may help reduce the cost of a mefenamic acid prescription and some insurance plans may help with costs associated with a mefenamic acid prescription.

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Can I Buy Mefenamic Acid Online?

Mefenamic acid requires a prescription to be obtained at a pharmacy in the United States. Due to this restriction, mefenamic acid OTC is not available and it is not possible to just buy mefenamic acid online as the initial step is getting a mefenamic acid prescription from a licensed medical provider. People who might need a mefenamic acid prescription, however, can connect with a licensed provider through Push Health who can prescribe mefenamic acid medication, including mefenamic acid 500 mg and mefenamic acid 250 mg tablets, when appropriate to do so.

Mefenamic Acid – Side Effects

Mefenamic acid prescription medication can cause side effects such as nausea, abdominal discomfort, vomiting and fatigue. People with a history of liver problems should generally avoid using mefenamic acid medication. Mefenamic acid can cause kidney dysfunction, particularly when used excessively. Prior to using mefenamic acid tablets, questions and concerns should be discussed with a pharmacist and qualified medical provider. Mefenamic acid and alcohol should generally not be used together. People with an allergy to mefenamic acid or similar medications should avoid using mefenamic acid prescription medication.

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More Mefenamic Acid Information

Mefenamic Acid – Medline

Last updated March 21, 2022. Given the evolving nature of medicine and science, this information might not be accurate and should not be construed as medical advice or diagnosis / treatment recommendations. Please consult a licensed medical provider if you have additional questions. Please call 911 immediately or go to the nearest emergency room if you believe you are experiencing a medical emergency.

Mefenamic acid-Darnitsa tablets 500 mg No. 20

Mefenamic acid-Darnitsa tablets 500 mg No.

Composition

active substance: mefenamic acid;

1 tablet contains mefenamic acid 500 mg;

excipients: potato starch, methylcellulose, croscarmellose sodium, stearic acid, magnesium stearate.

Dosage form

Tablets.

Basic physical and chemical properties: grayish-white tablets with a slightly yellowish or greenish tinge, flat-cylindrical shape, with a chamfer and a risk, marbling is allowed.

Pharmacotherapeutic group

Nonsteroidal anti-inflammatory and antirheumatic drugs. Fenamates. ATX code M01A G01.

Pharmacological properties

Pharmacodynamics.

Mefenamic acid is a non-steroidal anti-inflammatory drug. The mechanism of anti-inflammatory action is due to the ability to inhibit the synthesis of inflammatory mediators (prostaglandins, serotonin, kinins, etc.), to reduce the activity of lysosomal enzymes that are involved in the inflammatory response. Mefenamic acid stabilizes protein ultrastructures and cell membranes, reduces vascular permeability, disrupts the processes of oxidative phosphorylation, inhibits the synthesis of mucopolysaccharides, inhibits cell proliferation in the focus of inflammation, increases cell resistance and stimulates wound healing. Antipyretic properties are associated with the ability to inhibit the synthesis of prostaglandins and influence the center of thermoregulation.

Mefenamic acid stimulates the formation of interferon.

In the mechanism of analgesic action, along with the influence on the central mechanisms of pain sensitivity, a significant role is played by the local influence on the focus of inflammation and the ability to inhibit the formation of algogens (kinins, histamine, serotonin).

Pharmacokinetics.

After oral administration, mefenamic acid is rapidly and fairly completely absorbed from the gastrointestinal tract. The maximum concentration in the blood is observed 2 to 4 hours after ingestion. The blood level is proportional to the dose. The equilibrium concentration (20 μg / ml) is determined on the 2nd day of use (1 g 4 times a day). Contacts on 90% with blood albumin. In the liver, it forms metabolites by oxidation, hydrolysis, and glucuronidation. The half-life (T1 / 2) is 2 – 4 hours. Excreted from the body unchanged and in the form of metabolites mainly by the kidneys (67% of the dose), with feces (20-25%).

Indications

Acute respiratory viral infections and influenza.

Pain of low and moderate intensity: muscle, joint, traumatic, dental, headache of various etiologies, postoperative and postpartum pain.

Primary dysmenorrhea. Dysfunctional menorrhagia, including those caused by the presence of intrauterine contraceptives, in the absence of pathology of the pelvic organs.

Inflammatory diseases of the musculoskeletal system: rheumatoid arthritis, rheumatism, ankylosing spondylitis.

Contraindications

Hypersensitivity to the components of the drug. Bronchospasm, Quincke’s edema, rhinitis, bronchial asthma or a history of urticaria that occurred after the use of acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (NSAIDs). Simultaneous administration of specific COX-2 inhibitors. Peptic ulcer of the stomach and duodenum, including a history, inflammatory bowel disease, diseases of the hematopoietic organs, severe heart failure, severe liver or kidney dysfunction, gastrointestinal bleeding or perforation caused by the use of non-steroidal anti-inflammatory drugs.

Interaction with other drugs and other forms of interaction.

Thiamine, pyridoxine hydrochloride, barbiturates, phenothiazine derivatives, narcotic analgesics, caffeine, diphenhydramine increase the analgesic effect of the drug.
The combined use of mefenamic acid and methotrexate increases the toxic effects of methotrexate.

Antihypertensive agents (ACE inhibitors and angiotensin II receptor antagonists): decreased antihypertensive effect, increased risk of renal failure, especially in elderly patients. Patients should drink enough fluids. It is also necessary to evaluate renal function at the beginning of treatment and during concomitant therapy.

Diuretics: reduction of the diuretic effect. Diuretics may increase the nephrotoxicity of NSAIDs.

Cardiac glycosides: NSAIDs may exacerbate heart failure, reduce glomerular filtration rate and increase plasma levels of cardiac glycosides.
Cyclosporine: increased risk of nephrotoxicity.

Mifepristone: NSAIDs should not be taken within 8 to 12 days after taking mifepristone – NSAIDs may reduce the effect of mifepristone.

Corticosteroids: increased risk of gastrointestinal ulcers and bleeding.

Antiplatelet agents and selective serotonin reuptake inhibitors: increased risk of gastrointestinal bleeding.

Fluoroquinolones: NSAIDs increase the risk of seizures.

Aminoglycosides: NSAIDs increase the risk of nephrotoxicity.

Tacrolimus: possible increased risk of nephrotoxicity.

Zidovudine: NSAIDs increase the risk of hematological toxicity. There is an increased risk of joint hemorrhage and hematoma in HIV-positive hemophiliacs who are concomitantly treated with zidovudine.

Lithium preparations: decreased excretion of lithium and increased risk of lithium toxicity.
Mefenamic acid increases the activity of oral anticoagulants, so their simultaneous use increases the risk of bleeding. The simultaneous use of mefenamic acid with oral anticoagulants requires careful monitoring of prothrombin time. NSAIDs with warfarin or heparin should be used with extreme caution – medical supervision is necessary.

Simultaneous use with other non-steroidal anti-inflammatory drugs increases the anti-inflammatory effect and the likelihood of side effects from the gastrointestinal tract.

Application features

The drug is prescribed with caution to patients with acute cardiovascular insufficiency, arterial hypertension, coronary heart disease.

The drug is prescribed with caution in patients with epilepsy.

Do not use mefenamic acid in patients with a history of hypersensitivity reactions such as asthma, bronchospasm, rhinitis, angioedema or urticaria.

Do not use in dehydrated patients who have lost fluid due to vomiting, diarrhea or increased urination.

In case of long-term treatment of headache, consult your doctor.

There are no special recommendations for the use of the drug in moderate impairment of liver or kidney function.

NSAIDs should be used with caution in patients with a history of gastrointestinal disease (ulcerative colitis, Crohn’s disease), as exacerbation of the disease is possible. If the use of mefenamic acid has led to gastrointestinal bleeding and perforation, treatment should be discontinued.

Elderly patients generally have an increased risk of gastrointestinal side effects, especially gastrointestinal bleeding and perforation, which can be fatal, so treatment should be initiated at the lowest dosage.

Patients with systemic lupus erythematosus and mixed connective tissue diseases are at increased risk of aseptic meningitis.

Mefenamic acid should be used with caution in patients at high risk of serious skin reactions, including exfoliative dermatitis, Stevens-Johnson syndrome and toxic epidermal necrolysis. Mefenamic acid should be discontinued at the first appearance of a skin rash, mucosal injury, or any other sign of hypersensitivity.

With prolonged use of the drug, it is necessary to monitor blood parameters, since mefenamic acid can cause pathological changes in the blood. If manifestations of any dyscrasia occur, it is necessary to stop therapy with the drug.

Mefenamic acid may cause gastrointestinal disturbances (eg diarrhoea). They can occur both immediately after the use of the drug, and after prolonged use. If such symptoms occur, the drug should be discontinued.

Caution should be exercised when using mefenamic acid in patients receiving therapy with drugs that increase the risk of bleeding: corticosteroids, anticoagulants (warfarin) and aspirin.

Mefenamic acid may interfere with female fertility and is not recommended for women who are trying to become pregnant. When used by women with symptoms of dysmenorrhea and menorrhagia and the absence of a therapeutic effect, you should consult a doctor.

Use during pregnancy or lactation.

The drug is not used by women during pregnancy or lactation.

The ability to influence the rate of reactions when driving vehicles or operating other mechanisms.

Caution should be exercised when driving vehicles or working with mechanisms that require increased attention, as sometimes the use of the drug can cause drowsiness, blurred vision, convulsions.

Route of administration and doses

Use of the drug should be under the supervision of a physician, who determines the dose and duration of treatment. Apply inside. The drug should be taken after meals with milk.

Adults and children over 12 years old: 250-500 mg 3-4 times daily. According to the indications and with good tolerance, the daily dose is increased to a maximum of 3000 mg, after achieving a therapeutic effect, the dose is reduced to 1000 mg / day.

Children aged 5 to 12 years, 250 mg 3 to 4 times a day.

The course of treatment for diseases of the joints can last from 20 days to 2 months or more. In the treatment of pain syndrome, the course of treatment lasts up to 7 days.

Children.

The drug is contraindicated in children under 5 years of age.

Overdose

Symptoms: epigastric pain, nausea, vomiting, drowsiness. In severe cases – gastrointestinal bleeding, respiratory depression, arterial hypertension, twitching of certain muscle groups, coma.

Treatment. There is no specific antidote. Gastric lavage with activated charcoal suspension. Alkalinization of urine, forced diuresis. Symptomatic therapy. Hemosorption and hemodialysis are ineffective due to the strong binding of mefenamic acid to blood proteins.

Adverse reactions

On the part of the organs of vision: blurred vision, reversible loss of the ability to distinguish colors, eye irritation.

From the hearing organs and vestibular apparatus: ringing in the ears, otalgia.

On the part of the respiratory system, chest organs and mediastinum: dyspnea, bronchospasm.

From the gastrointestinal tract: pain in the epigastric region, anorexia, heartburn, nausea, flatulence, vomiting, enterocolitis, colitis, exacerbation of colitis and Crohn’s disease, gastritis, hepatotoxicity, steatorrhea, cholestatic jaundice, hepatitis, pancreatitis, hepatorenal syndrome, hemorrhagic gastritis, peptic ulcer with or without bleeding. Gastrointestinal bleeding, perforation or gastrointestinal bleeding, sometimes fatal, especially in elderly patients, dyspepsia, constipation, diarrhea.

From the side of the kidneys and urinary system: dysuria, cystitis. Renal dysfunction, albuminuria, hematuria, oliguria or polyuria, renal failure, including papillary necrosis, acute interstitial nephritis, nephrotic syndrome, allergic glomerulonephritis, hyponatremia, hyperkalemia.

From the nervous system: drowsiness or insomnia, weakness, irritability, agitation, headache, blurred vision, convulsions, optic neuritis, paresthesia, dizziness, stiff neck, fever, disorientation. On the part of the psyche: confusion, depression, hallucinations.

From the side of the cardiovascular system: arterial hypertension, arrhythmia, rarely – congestive heart failure, peripheral edema, syncope, arterial hypotension, palpitations, shortness of breath, thrombotic complications (for example, myocardial infarction or stroke).

On the part of the blood and lymphatic system: aplastic anemia, autoimmune hemolytic anemia, prolongation of bleeding time, eosinophilia, leukopenia, thrombocytopenia, decreased hematocrit, thrombocytopenic purpura, agranulocytosis, neutropenia, pancytopenia, bone marrow hypoplasia.

From the immune system: hypersensitivity reactions, including skin rashes, pruritus, facial edema, allergic rhinitis, angioedema, laryngeal edema, Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme, urticaria, bullous pemphigus, photosensitivity, asthma, anaphylaxis.

From the side of the skin and subcutaneous tissue: purpura, skin rashes, pruritus, erythema multiforme, urticaria, bullous pemphigus.

Laboratory indicators: impaired glucose tolerance in patients with diabetes mellitus, a positive reaction in some tests for the presence of mefenamic acid and its metabolites in bile and urine. Increased levels of liver enzymes in blood plasma.

Others: aseptic meningitis, sweating, fatigue, malaise, multiple organ failure, hyperthermia.

Shelf life

2 years.

Storage conditions

Keep out of the reach of children in the original packaging at a temperature not exceeding 25 °C.

Packaging

10 tablets in a blister pack; 2 blisters in a pack.

Dispensing category

Without a prescription.

Producer

PrJSC “Pharmaceutical firm “Darnitsa”.

Manufacturer’s location and address of the place of business.

Ukraine, 02093, Kyiv, st. Borispolskaya, 13.

Mefenamic acid capsules 250 mg No. 20

Mefenamic acid is a drug from the group of non-steroidal anti-inflammatory drugs. The active substance, mefenamic acid, belongs to anthranilic acid derivatives, the molecular structure is similar to salicylic acid. The substance was developed by the pharmaceutical company Parke, Davis & Company, the first patent for mefenamic acid was received in 1961 years old. Immunomodulatory properties have been studied since the 1980s.

Mefenamic acid has various trade names and can also be included in a combination drug.

The main therapeutic effects of Mefenamic acid on the body:

analgesic – a central effect on pain sensitivity, as well as local activity in the focus of inflammation; anti-inflammatory – prevents the production of inflammatory mediators and reduces the permeability of the vascular walls; antipyretic – inhibits the synthesis of hypothalamic enzymes and prostaglandins, has a direct effect on the center of thermoregulation; immunomodulatory – stimulates the production of interferons and increases the functional activity of T-lymphocytes.

The drug is approved for use in children of different ages:

in the form of capsules of 250 mg and 500 mg is recommended for children over 12 years of age; 500 mg tablets are used in patients older than 5 years.

The prescribed dosages must be adhered to in order to avoid undesirable effects, which are most often manifested in the gastrointestinal tract.

A special condition for the use of mefenamic acid is taking the drug after meals and washing down the tablets with milk.

The drug is indicated for acute respiratory infections, influenza, pain of varying intensity, as well as inflammatory diseases of the musculoskeletal system.

Mefenamic acid is used both as monotherapy and in combination with other drugs. The synergism of the immunomodulatory effect of Mefenamic acid and antiviral drugs has been proven.

The duration of the effect after taking the drug at a dose of 500 mg is up to 8 hours.

Clinical trials have shown a reduction in the duration of the course of the disease and a decrease in the intensity of symptoms in ARVI and influenza. Mefenamic acid also reduces the risk of post-influenza complications. In the course of observations, no serious side effects were registered when following the recommendations for use.

To exclude threatening symptoms and make a correct diagnosis, it is necessary to consult with your doctor.