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Can you take clindamycin for sinus infection: CLINDAMYCIN | Doctors Urgent Care

Can You Use Clindamycin for Sinus Infection?

This article is a comprehensive guide to using clindamycin for sinus infection. Read on to learn helpful information about the potential risks, benefits, dosage instructions, and more so that you can make a knowledgeable decision when deciding whether or not this drug is right for you.

Sinusitis can be a painful and debilitating experience. Not only does the unbearable pressure cause severe headaches, but it can also lead to fatigue and even fever if left untreated.

The best way to relieve sinusitis pain is often through antibiotic therapy like clindamycin. But what exactly is clindamycin, how effective is it for treating sinusitis, and are there any side effects associated with using this drug?

What Is clindamycin?

Clindamycin is an antibiotic drug that belongs to the lincosamide family of drugs. It is widely used to treat infections, such as skin, urinary and respiratory infections, including sinusitis.

This medication is available in both oral and topical forms and works by inhibiting the growth of bacteria by blocking the production of proteins that bacteria need to survive.

Clindamycin has become a popular choice for treating sinusitis because of its efficacy and fewer side effects than other antibiotics.

Studies have shown that clindamycin is very effective in treating acute bacterial sinusitis after 10 days of treatment and usually does not require additional antibiotics.

It is also much less likely to cause an overgrowth of other bacteria or produce antibiotic resistance.

Although clindamycin is generally safe and well-tolerated, some people may experience side effects, such as nausea, vomiting, diarrhea, rash, and yeast infections.

In addition, in rare cases, it can cause a severe allergic reaction, so it is essential to talk to your healthcare professional before starting a course of treatment.

Clindamycin can also interact with certain medications, so it is important to tell your healthcare professional about any other drugs you are taking.

Can You Use Clindamycin For Sinus Infection?

Clindamycin is an antibiotic often prescribed to treat infections caused by bacteria, including sinusitis. It is in the class of medicines known as lincosamides, similar to penicillin but has a broader range of activity against certain infections caused by bacteria.

Clindamycin works by limiting the growth of bacteria and allowing the body’s immune system to fight off the infection.

This can help reduce the pain and discomfort associated with a sinus infection and clear up the condition more quickly.

Clindamycin has become increasingly popular in recent years due to its effectiveness in treating sinusitis.

Studies have found that it has a higher success rate than other antibiotics in curing sinusitis caused by certain bacteria. It is also effective in treating sinusitis resistant to other antibiotics.

In addition, it is generally a well-tolerated drug with few side effects, making it an attractive choice for treating sinusitis.

However, as with all antibiotics, it is essential to take the entire course of the drug as prescribed by your doctor and to make lifestyle changes to reduce the risk of future infection.

How good is clindamycin for sinus infection?

Clindamycin is generally considered a safe and effective acute sinusitis treatment if directed.

Additionally, it’s important to note that clindamycin has potential adverse effects, like with many antibiotics.

The most prevalent side effects include nausea, vomiting, and diarrhea, although severe side effects are rare.

It’s essential to speak to your doctor if you experience any of these side effects, as they may suggest an alternative treatment.

Overall, clindamycin is a safe and effective treatment option for chronic and acute sinusitis as long as it is prescribed.

Following your doctor’s instructions and taking the medication as directed can help reduce your symptoms and relieve chronic sinusitis pain.

How can clindamycin treat acute sinusitis?

Clindamycin is an antibiotic that is often prescribed to treat sinusitis. It works by stopping bacteria from multiplying, thereby reducing the duration and severity of the infection.

Clindamycin is especially effective against acute bacterial conditions caused by Streptococcus, commonly found in the sinuses.

However, it is essential to note that clindamycin does not work against viral infections, so you must seek other treatment options if you have a viral infection.

In conclusion, clindamycin is a popular antibiotic for treating acute and chronic sinusitis. It is generally well tolerated and effective in controlling infections caused by bacteria.

How long does it take for clindamycin to work?

Clindamycin is an antibiotic that is commonly used to treat sinusitis. It eliminates the bacteria that cause the infection.

However, depending on the severity of the infection, it can take several days to a few weeks for the full benefits of the antibiotic to be seen.

Therefore, taking the medication as prescribed is crucial to get optimal treatment and ensure the infection does not return.

In most cases, clindamycin will improve a person’s symptoms within a few days of starting the antibiotic.

However, it is crucial to understand that this does not necessarily imply the infection has been fully cleared.

Instead, it means that the antibiotic has begun to work and that the patient will likely experience some improvements in their symptoms. However, this is not a guarantee.

Therefore, it is essential to continue taking the medication until the entire course is finished to ensure the infection has been fully treated and reduce the chances of the infection returning.

Related: Clindamycin vs Doxycycline: Similarities, Differences, and Uses

What Conditions does clindamycin Treat?

Clindamycin is an antibiotic used to treat a variety of infections. It works by limiting the growth of bacteria, thus stopping the condition from worsening.

Clindamycin is commonly prescribed for sinusitis, both acute and chronic.

It effectively treats the infection-causing bacteria, usually Staphylococcus, Streptococcus, and Haemophilus species.

Clindamycin is also used to treat other bacterial infections, such as soft tissue and skin infections, sore throat, urinary and upper respiratory tract infections, and pneumonia. Additionally, clindamycin is also used to prevent infections caused by bacteria in people undergoing certain types of surgery or who have weakened immune systems.

While clindamycin is generally safe, speaking with a doctor and reporting any side effects that may occur when taking this medication is crucial.

Common side effects of clindamycin include nausea, vomiting, and upset stomach.

Overall, clindamycin is an effective antibiotic for infections caused by bacteria. However, speaking with a medical expert before taking any medication and reporting any side effects is crucial.

What Forms Does clindamycin Come In?

Clindamycin is available in multiple forms, including oral solutions, capsules, tablets, and topical creams.

The most common form of clindamycin for treating sinusitis is an oral solution taken thrice daily.

However, if sinusitis is more severe, a doctor may prescribe a higher clindamycin dosage or suggest a topical cream.

Additionally, before starting any antibiotic treatment, it is crucial to inform the doctor of any other medications being taken, as there may be interactions between the drugs.

Clindamycin is a solid and effective antibiotic that can treat sinus and other infections caused by bacteria. Still, it is crucial to be aware of the potential side effects.

Side Effects Of Clindamycin For Sinusitis

Clindamycin has been an antibiotic used to treat various infections, including sinusitis, for many years.

Clindamycin is generally safe and well-tolerated when taken correctly, but some potential side effects can occur.

These include:

  • Nausea,
  • Vomiting,
  • Diarrhea,
  • Abdominal pain
  • Changes in appetite

In addition, in rare cases, patients may experience allergic reactions such as hives, difficulty breathing, and swelling of the face and throat.

Clindamycin can also cause a fall in the white blood cell count, escalating the risk of infection. Therefore, you must contact your doctor if you experience these symptoms while taking clindamycin.

It is important to remember that although clindamycin for sinus infection might be effective, it may not be the optimal option for everyone.

Some people may be more prone to side effects and should discuss the risks with their doctor before taking clindamycin.

It is also essential to take the medication exactly as prescribed and finish the entire course of treatment, even if symptoms improve.

This will ensure that the infection is completely eradicated and prevent a recurrence.

Read Also: Sinus Infection in Kids: Causes, Symptoms, Treatment & More

Dosage Of Clindamycin For Sinusitis

The recommended dosage of clindamycin for sinus infection differs from person to person.

It is typically prescribed as a capsule or oral solution and is usually taken twice to four times daily for 7 to 10 days.

However, it is essential to consult with a doctor for the exact dosage as it depends on how severe the infection is and the patient’s medical history. Your doctor might conduct a physical examination or sinus puncture to determine your condition accurately.

Clindamycin is an effective and widely used antibiotic for treating sinusitis.

However, it is essential to consult a doctor to prescribe the correct dosage for each individual.

Doing this allows the patient to get the most effective and safest treatment for their infection.

Frequently Asked Questions (FAQs)

Should people treat sinus infection with antibiotics?

Doctors may prescribe antibiotics for a bacterial sinus infection, also called bacterial sinusitis. The type of treatment a person requires will vary depending on symptoms and infection severity.

When an individual has a sinus infection, fluids accumulate in the air-filled cavities in the face. Typically, these sinuses have a thin lining of mucus that collects dust, germs, and other particles from the air.

Tiny hair-like projections, called cilia, sweep the mucus and any particles trapped down the back of the throat into the stomach. However, in sinusitis, the mucus does not flow freely, and germs can multiply.

Sinusitis, also called rhinosinusitis, is one of the most common reasons people visit doctors in the United States. Almost 15% of the population experiences sinus infections each year, and it is one of the top conditions that doctors prescribe antibiotics for.

This article looks at antibiotics for a sinus infection, their benefits, and alternative treatment methods, including some natural remedies.

An individual does not always need antibiotics for a sinus infection. Many sinus infections improve without antibiotic treatment. In addition, because many sinus infections are viral in origin, antibiotics do not help in these cases and can cause unpleasant side effects.

Side effects can range from minor problems such as rashes to severe health issues, including antibiotic-resistant infections.

People should therefore discuss their symptoms with a doctor and find out the best treatment for them. Doctors will only recommend antibiotics when they suspect bacterial sinusitis.

Antibiotics are beneficial for bacterial sinusitis only. If an individual has a viral, fungal, or other sinus infection, antibiotics do not offer any benefits.

If a person has bacterial sinusitis, treatment with appropriate antibiotics can help resolve the infection. However, evidence shows that antibiotic therapy may not shorten symptom duration or lessen the likelihood of developing complications.

In fact, research shows that antibiotic treatment cures just 5–11% of people more quickly than if they receive no treatment. Many cases of bacterial sinusitis clear up by themselves within two weeks.

Doctors often suggest 10–14 days of treatment with amoxicillin or amoxicillin-clavulanate if an individual has bacterial sinusitis.

However, amoxicillins have become less effective in some areas because of antibiotic resistance. In these cases, a doctor may suggest switching to another antibiotic if there is no improvement in symptoms after a few days. The alternatives include:

  • doxycycline
  • fluoroquinolones
  • cefixime with clindamycin

Doctors may recommend the following nonantibiotic treatments for sinusitis:

  • Nasal decongestants: Over-the-counter nasal decongestant sprays can help relieve symptoms of stuffiness. Options include pseudoephedrine and oxymetazoline. However, people should only use them for up to three days.
  • Antihistamines: People with early stage allergic sinusitis may find these allergy medications helpful.
  • Nasal corticosteroid sprays: These medications reduce inflammation and swelling in the sinuses. However, they are most effective in chronic and allergic sinusitis.
  • Pain relievers: Using acetaminophen or ibuprofen may help if an individual experiences facial pain.

Individuals with sinus infections could find the following natural remedies helpful in relieving uncomfortable symptoms:

  • Resting: Resting while the body fights infection helps speed recovery.
  • Humidifying the air: Keep the air moist with a humidifier or cool air vaporizer.
  • Nasal washing: Saline nasal rinses can help flush out allergens, germs, and mucous plugs from the sinuses. People can also use a neti pot with previously boiled and cooled water.
  • Drinking fluids: Drinking plenty of water or fruit juice helps keep the mucous membranes moist and promotes proper drainage from the sinuses.
  • Inhaling steam: This involves pouring boiled water into a large bowl and leaning over while inhaling the water vapor. Usually, the individual drapes a towel over the back of their head, creating a tent over the bowl to trap the steam. The moist, hot air helps ease sinus pain and drainage. People can enjoy a similar effect from a hot shower.
  • Using a warm compress: Applying heat to the sinuses using a warm washcloth may help ease uncomfortable sinus pressure. Ensure the compress is not hot enough to harm the skin.
  • Elevating the head while sleeping: This position allows the sinuses to drain more easily and reduces congestion.

People may experience the following symptoms of sinus infections:

  • facial pain
  • facial pressure
  • runny nose
  • blocked nose
  • headache
  • mucus at the back of the throat
  • sore throat
  • cough
  • bad breath

A combination of environmental and other factors can cause sinus infections, including:

  • viruses
  • bacteria
  • fungi
  • allergens such as pollen
  • irritants such as smoke and dust

Viruses are the most common cause of sinus infections, and around 90% of people with colds have some form of viral sinusitis.

Viral sinusitis is usually self-limiting. However, an individual should make an appointment with their doctor if they experience the following:

  • worsening symptoms
  • severe headaches or facial pain
  • symptoms that do not improve after 10 days
  • a fever lasting longer than 4 days
  • any concerning symptoms

Additionally, people should seek medical attention if they have had multiple sinus infections in the past year.

A sinus infection causes fluids to accumulate in the air-filled cavities in the face, and mucus no longer flows freely. Viruses and bacteria can then multiply and cause uncomfortable symptoms. These include facial pain, a runny or stuffy nose, and a cough.

Sinus infections can also occur due to irritants, allergens, and fungi.

Individuals do not always need antibiotics for sinus infections and using them when unnecessary can lead to unpleasant side effects. However, if a doctor believes the cause is bacterial, they may prescribe them.

If a person has bacterial sinusitis, antibiotics can help. But it is important to note that most cases of bacterial sinusitis clear up without treatment within 2 weeks.

People can help ease symptoms by inhaling steam, keeping the surrounding air moist, using nasal decongestants, and taking over-the-counter pain-relieving medication.

list of the top 5 best and inexpensive remedies according to KP

Runny nose is one of the most common symptoms of many infectious and inflammatory diseases of the respiratory tract. In most cases, the cause of this disease is a respiratory virus that does not require special treatment. However, sometimes a runny nose can be a symptom of a serious illness caused by bacteria. Then the appointment of antibiotic therapy is a mandatory stage of treatment.

Sinusitis – inflammation of the mucous membrane of the maxillary paranasal sinus. Another name for the disease is maxillary sinusitis 1 . In 90-98% of cases, the cause of sinusitis are viruses. However, in 2-10% of cases, sinusitis is caused by bacteria that require antibiotic therapy.

Important! Selection of therapy should be carried out only by a doctor, taking into account symptoms, anamnesis, laboratory and instrumental data.

Consider the most effective and inexpensive antibiotics for adult sinusitis that are approved by practitioners and prescribed to patients.

List of top 5 antibiotics for sinusitis according to KP

Important! All drugs have side effects and contraindications. Our material is an overview and does not serve as a guide to action. Before buying drugs, consult your doctor.

Patients with sinusitis may be prescribed antibiotics from several pharmacological groups:

  • penicillins;
  • cephalosporins;
  • macrolides;
  • fluoroquinolones;
  • lincosamides.

Penicillins

Penicillins are the main drugs of choice in the treatment of sinusitis. They are active against a wide range of pathogenic bacteria and can be prescribed from the first days of the disease even before the pathogen is identified. For the treatment of uncomplicated sinusitis, one of the representatives of this group is used – the beta-lactam antibiotic amoxicillin 1 . Perhaps the use of amoxicillin in combination with clavulanic acid, which enhances the effect of the antibiotic.

Contraindications for use: hypersensitivity, lymphocytic leukemia, infectious mononucleosis, severe gastrointestinal infections, allergic diathesis, bronchial asthma, hay fever.

Cephalosporins

II and III generation cephalosporins are used if the causative streptococcus is suspected to be resistant to beta-lactam antibiotics, particularly amoxicillin. Clinical guidelines of the Ministry of Health of the Russian Federation approved the use of cefuroxime, cefixime and cefditoren, which are prescribed in tablets and other forms for oral administration 1 .

Cephalosporins have a bactericidal effect: they contribute to the disruption of the synthesis of the bacterial cell wall, causing their death.

Contraindications for use : Hypersensitivity to cephalosporins, penicillins and carbapenems.

Macrolides

Macrolides are alternative drugs for the treatment of sinusitis. They are used if the causative agent of the disease is resistant to beta-lactam antibiotics, or the patient is allergic to them.

Josamycin and clarithromycin in the form of tablets, capsules and other oral forms can be used in therapy. These antibiotics disrupt protein synthesis in the microbial cell, slow down or stop the growth of bacteria, and in high concentrations cause their death. Macrolides are considered one of the least toxic groups of antibiotics and are generally well tolerated.

Contraindications for : hypersensitivity to macrolides, severe liver failure.

Fluoroquinolones

This group of antibiotics is prescribed in extreme cases and only in adult patients. The fact is that fluoroquinolones negatively affect the growing cartilaginous and connective tissue, therefore they are contraindicated in children and adolescents. Fluoroquinolones are recommended for severe sinusitis, for suspected polysinusitis, and for persistent structural changes in the nasal cavity.

Levofloxacin or monofloxacin tablets and other oral dosage forms may be used.

Contraindications for use : hypersensitivity to fluoroquinolones, pregnancy, lactation, age under 18 years, electrolyte disturbances, clinically significant bradycardia, heart failure, abnormal liver function.

Lincosamides

Clindamycin is an antibiotic from the lincosamide group that is active against a wide range of bacteria. Clindamycin disrupts protein synthesis in the bacterial cell, which slows down or completely stops its growth.

Clindamycin for sinusitis is prescribed for allergies to beta-lactam antibiotics and if there is a risk of anaerobic infection. In the latter case, a combination of clindamycin with third-generation cephalosporins can be used. Clindamycin preparations are used for intramuscular injection.

Contraindications for the use of : myasthenia gravis, ulcerative colitis, bronchial asthma, pregnancy, lactation, hypersensitivity to components.

How to choose antibiotics for sinusitis for adults

Independent choice of antibiotic therapy is not allowed! Treatment should be prescribed by a doctor individually, taking into account the clinical picture of the disease, the patient’s history, laboratory and instrumental data. The most important thing is to determine whether antibiotics are needed at all?

Let’s list the main symptoms that will make it possible to suspect a bacterial infection:

  • symptoms (nasal congestion, headaches, general weakness) by 4-5 days do not weaken, but only increase;
  • body temperature does not drop below 37. 5 degrees;
  • nasal discharge becomes yellow-green and copious;
  • in the paranasal sinuses there is a feeling of fullness and pressure;
  • Soreness around the nose and eyes.

The “gold standard” for diagnosing a bacterial infection is nasal culture and sensitivity to antibiotics. Only then can you be sure of the correctness of the prescribed therapy.

The main differences in antibacterial drugs lie in their mechanism of action.

Penicillins and cephalosporins inhibit the formation of proteins necessary for building the cell wall of the microorganism. Macrolides stop the growth and reproduction of bacterial cells. Fluoroquinolones interfere with DNA synthesis in the microbial cell.

Antibiotics are also divided into first-line, second-line and alternative drugs. The appointment of each group is carried out strictly according to indications. It is best to entrust the treatment to a specialist and avoid serious complications in the future!

Popular Questions and Answers

We discussed important issues related to the prescription of antibiotics for sinusitis with Tatyana Pomerantseva , the highest category general practitioner .

Can sinusitis be cured without antibiotics?

— The cause of sinusitis in 90-98% of cases are viruses. This does not require specific treatment, but only symptomatic to alleviate the general condition.

Only 2-10% of cases of sinusitis are caused by bacteria, and then antibiotic therapy is necessary. Therefore, it is possible to cure sinusitis without antibiotics, you just need to be sure that the cause is not a bacterium.

Is it possible to buy antibiotics for sinusitis without a prescription?

— No, all antibiotics are prescription drugs. Only a doctor after examination, collection of complaints and anamnesis of the disease, laboratory and instrumental data can choose the right antibiotic.

What if antibiotics do not help with sinusitis?

– Unfortunately, this is one of the most frequently asked questions. In most cases, antibiotics are ineffective because the cause of the disease is a virus.

Another cause is the wrong drug or dosage. Antibiotic resistance (resistance to antibiotics) is common, so a preliminary nasal culture with the determination of the sensitivity of microorganisms is a necessary diagnostic method.

References :

  1. Clinical guidelines of the Ministry of Health of the Russian Federation for the treatment of acute sinusitis. 2021
    https://cr.minzdrav.gov.ru/schema/313_2#doc_v

Acute sinusitis. ABC of antibiotic therapy. Vidal medicines guide

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The materials are intended exclusively for physicians and specialists with higher medical education. Articles are informational and educational in nature. Self-medication and self-diagnosis are extremely dangerous for health. The author of the articles does not give medical advice: a clinical pharmacologist is a doctor only and exclusively for doctors.

Pathogens

  • Rhinovirus and other viruses
  • S. pneumoniae
  • Haemophilus influenza
  • Less common pathogens include M. catarrhalis, S. aureus and anaerobes

Clinical

  • Main causes : viral infections of the upper respiratory tract, allergies, anatomical defects, smoking, dental infections, swimming
  • Classification: Acute – 12 weeks
  • Bacterial infection rarely develops before day 7
  • Viral infections and allergies are much more common causes of sinusitis than acute bacterial sinusitis
  • Symptoms of nasal congestion, feeling of pressure or pain in the face, rhinorrhea, decreased sense of smell
  • Purulent discharge from the nose +/- pain/tenderness in the upper jaw and in the forehead or blackout on diaphanoscopy
  • Physical examination does not usually provide additional benefit
  • Complications: orbital infections, meningitis, brain abscess or cavernous sinus thrombosis, all very rare

Diagnosis

  • Only 0. 2-10% of cases of clinical sinusitis are bacterial in nature – on average, the probability is no more than 2% of cases
  • In general, no tests other than culture, CT, or radiography are recommended
  • Culture is of no use unless the culture is from the sinus area
  • Really effective microbiological examinations can only be obtained after a sinus puncture, or during endoscopy, which is rarely performed in normal sinusitis

Treatment

Antibiotics

  • Principles: most sinusitis is either viral or allergic; usually an indication for antibiotics is symptomatic more than 7 days old
  • Almost all antibiotics for treatment are selected empirically
  • Preferred antibacterials : amoxicillin 0.5-1.5 g PO 3 times a day x 10-14 days; amoxicillin/clavulanate 875/125 mg PO twice daily or cefpodoxime 200-400 mg PO twice daily x 10-14 days
  • Alternative : azithromycin 2 g x 1 dose or 500 mg PO once a day x 3 days; clarithromycin 500 mg PO twice daily x 14 days, doxycycline 100 mg PO twice daily, or trimethoprim/sulfamethoxazole DS ( bactrim forte ) twice a day RO twice a day x 10-14 days
  • In severe cases, and in cases of non-response to treatment, or if there is a history of recent antibiotic use: fluoroquinolones (levofloxacin 500 mg PO daily or moxifloxacin 400 mg PO daily, or amoxicillin/clavulanate 875/125 RO twice a day x 5- 14 days

Additional therapeutic measures

  • System decongestants: pseudo-epedrine 120 mg + antihistamines with a sedative effect of RO twice a day 1-2 weeks, acetylsalicylic acid, ascetaminophen (paracetamol) or ibuprofen
  • Topical nasal sprays: oxymetazoline nasal spray 2 doses twice a day x 5 days – avoid more than 5 days
  • Allergic rhinitis: Loratadine (Claritin) 10 mg RO once daily or Flunisolide (Ingacort) 2 doses in each nostril per day
  • Not proven effective: vitamin C, zinc, vapor inhalation

Complicated sinusitis

  • A complication should be considered if there is periorbital edema, redness, pain in the face +/– mental status has changed
  • CT imaging required and referral to an otolaryngologist
  • Use ceftriaxone, ciprofloxacin, levofloxacin, moxifloxacin, amoxicillin/clavulanate
  • Endoscopy +/- drainage at the otorhinolaryngologist

Fractional regimen

Preferred antibiotics (Otolaryngology – head and Neck Surgery, 2004; 130:1)

  • Usually: amoxicillin (1. 5-4.5 g/day), amoxicillin /clavulanate, cefpodoxime, cefdinir ( not registered in RF ), cefuroxime
  • For beta-lactam allergy, fluoroquinolones
  • Modern effective antibiotics: fluoroquinolones, amoxicillin/clavulanate, clindamycin+cefixime. If there is no effect after 72 hours from the start of treatment: fluoroquinlones, amoxicillin 3-4.5 g / day, clindamycin + cefixime, amoxicillin / clavulanate
  • Complications: orbital cellulitis, osteomyelitis of the frontal bone, extradural or subdural empyema

Conclusion

  • If no response to ongoing therapy within 72 hours, perform imaging and change antibiotic therapy to fluoroquinolones and amoxicillin/clavulanate

More information

  • The most common complication of a cold is viral sinusitis that does not respond to antibiotics
  • If antibiotic therapy is needed, amoxicillin is the drug of choice, but higher doses may be required (eg, 3 g/day)

Literature


  • Jay F. Piccirillo, M.D. clinical practice. Acute bacterial sinusitis. N Engl J Med 2004; 351:902-910 – http://www.nejm.org/doi/full/10.1056/NEJMcp035553
  • Vincenza Snow, MD; Christel Mottur-Pilson, PhD; John M. Hickner, MD, MSc. Principles of Appropriate Antibiotic Use for Acute Sinusitis in Adults. Ann Intern Med. 2001;134(6):495-497. – http://annals.org/article.aspx?articleid=714356 (abstract, access to the full-text article is paid)
  • Hickner JM, Bartlett JG, Besser RE, Gonzales R, Hoffman JR, Sande MA Principles of appropriate antibiotic use for acute rhinosinusitis in adults: background . Ann Intern Med. 2001 Mar 20;134(6):498-505 . – http://annals.org/article.aspx?articleid=714357 (abstract, access to the full-text article is paid)
  • E.I. Kamanin. R.S. Kozlov, A.V. Veselov. Acute bacterial rhinosinusitis. Wedge microbiol antimicrobe chemother. 2008, Volume 10, No. 1 – http://www.

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