What are the common side effects of cefdinir. How can you avoid potential drug interactions with cefdinir. What precautions should be taken when using this antibiotic.

Understanding Cefdinir: An Overview of the Antibiotic

Cefdinir is a third-generation cephalosporin antibiotic used to treat various bacterial infections. It belongs to the class of medications known as beta-lactam antibiotics, which work by interfering with the cell wall synthesis of bacteria, ultimately leading to their death. Cefdinir is commonly prescribed for respiratory tract infections, skin infections, and urinary tract infections.

This antibiotic is available in both capsule and oral suspension forms, typically prescribed for a duration of up to 10 days, depending on the specific infection being treated. The standard adult dosage is usually 300 mg taken twice daily or 600 mg taken once daily.

What infections does cefdinir treat?

Cefdinir is effective against a wide range of bacterial infections, including:

• Bronchitis
• Sinusitis
• Pharyngitis (sore throat)
• Otitis media (middle ear infection)
• Pneumonia
• Skin and soft tissue infections
• Urinary tract infections (UTIs)

Common Side Effects of Cefdinir

While cefdinir is generally well-tolerated, it can cause various side effects. It’s important to be aware of these potential adverse reactions when taking the medication.

What are the most frequent side effects of cefdinir?

The most common side effects of cefdinir include:

• Diarrhea
• Nausea
• Vomiting
• Headache
• Abdominal pain
• Vaginal yeast infection (in females)
• Rash

These side effects are typically mild and often resolve on their own as your body adjusts to the medication. However, if they persist or worsen, it’s important to consult your healthcare provider.

Diarrhea: A Common Concern with Cefdinir

Diarrhea is one of the most frequently reported side effects of cefdinir. This occurs because the antibiotic can disrupt the normal balance of bacteria in the gut, leading to changes in bowel movements.

How can you manage diarrhea caused by cefdinir?

To manage diarrhea while taking cefdinir:

1. Stay hydrated by drinking plenty of fluids
2. Eat probiotic-rich foods or take probiotic supplements
3. Avoid foods that can exacerbate diarrhea, such as spicy or fatty foods
4. Consider over-the-counter antidiarrheal medications, but consult your doctor first

If diarrhea becomes severe or persists for more than a few days, contact your healthcare provider, as it could be a sign of a more serious condition.

Yeast Infections: A Potential Side Effect in Women

Vaginal yeast infections are a common side effect of cefdinir in women. This occurs because the antibiotic can disrupt the natural balance of microorganisms in the vagina, allowing for overgrowth of yeast.

How can women prevent or treat yeast infections while taking cefdinir?

To reduce the risk of developing a yeast infection:

• Wear breathable, cotton underwear
• Avoid tight-fitting clothing
• Consume probiotic-rich foods or supplements
• Consider using over-the-counter antifungal treatments if symptoms develop

If symptoms persist or worsen, consult your healthcare provider for appropriate treatment options.

Serious Side Effects of Cefdinir

While less common, cefdinir can cause more severe side effects that require immediate medical attention.

What are the serious adverse reactions associated with cefdinir?

Serious side effects of cefdinir may include:

• Severe allergic reactions (anaphylaxis)
• Stevens-Johnson syndrome (a severe skin reaction)
• Clostridium difficile-associated diarrhea (CDAD)
• Kidney problems
• Liver dysfunction
• Blood disorders

If you experience symptoms such as difficulty breathing, severe skin rashes, persistent diarrhea, or unusual bleeding or bruising, seek medical attention immediately.

Cefdinir Rash: When to Be Concerned

Skin rashes are a potential side effect of cefdinir, ranging from mild to severe. While most rashes are harmless and resolve on their own, some can be indicative of a more serious allergic reaction.

How can you differentiate between a harmless rash and a severe allergic reaction?

A harmless rash typically:

• Appears as mild redness or small bumps
• Is not accompanied by other severe symptoms
• Resolves on its own within a few days

A severe allergic reaction may include:

• Widespread, severe rash or hives
• Swelling of the face, lips, tongue, or throat
• Difficulty breathing or swallowing
• Fever or joint pain

If you experience symptoms of a severe allergic reaction, discontinue the medication and seek immediate medical attention.

C. Difficile Infection: A Serious Concern

Clostridium difficile-associated diarrhea (CDAD) is a potentially serious complication that can occur with antibiotic use, including cefdinir. C. difficile is a type of bacteria that can overgrow in the intestines when the normal gut flora is disrupted by antibiotics.

What are the symptoms of C. difficile infection?

Symptoms of C. difficile infection may include:

• Severe, persistent diarrhea
• Abdominal pain or cramping
• Fever
• Blood or mucus in the stool
• Loss of appetite
• Nausea

If you develop these symptoms during or after cefdinir treatment, contact your healthcare provider immediately. CDAD can be life-threatening if left untreated.

Cefdinir Side Effects in Seniors

Older adults may be more susceptible to certain side effects of cefdinir due to age-related changes in kidney function and overall health status.

What special considerations should be taken for elderly patients using cefdinir?

For seniors taking cefdinir:

• Dosage adjustments may be necessary based on kidney function
• Close monitoring for side effects is important
• Increased risk of C. difficile infection should be considered
• Potential interactions with other medications should be carefully evaluated

Healthcare providers should assess the benefits and risks of cefdinir use in elderly patients on an individual basis.

Duration of Cefdinir Side Effects

The duration of side effects from cefdinir can vary depending on the individual and the specific adverse reaction.

How long do cefdinir side effects typically last?

Most common side effects of cefdinir, such as diarrhea, nausea, and headache, usually subside within a few days to a week after starting the medication. However, some effects may persist throughout the course of treatment.

If side effects continue beyond the treatment period or worsen over time, it’s important to consult your healthcare provider. They may recommend adjusting the dosage or switching to a different antibiotic if necessary.

Cefdinir Warnings and Precautions

Before taking cefdinir, it’s crucial to be aware of certain warnings and precautions to ensure safe and effective use of the medication.

What important warnings should patients know about cefdinir?

Key warnings and precautions for cefdinir include:

• Allergic reactions: Inform your doctor if you have a history of allergies to cephalosporins, penicillins, or other antibiotics
• Kidney problems: Dosage adjustments may be necessary for patients with impaired kidney function
• Pregnancy and breastfeeding: Consult your healthcare provider about the risks and benefits of using cefdinir during pregnancy or while breastfeeding
• Antibiotic resistance: Complete the full course of treatment as prescribed to prevent the development of antibiotic-resistant bacteria
• Seizure disorders: Cefdinir may increase the risk of seizures in patients with a history of seizure disorders

Always inform your healthcare provider about your complete medical history and any medications you are currently taking before starting cefdinir treatment.

Drug Interactions with Cefdinir

Cefdinir can interact with various medications, potentially altering its effectiveness or increasing the risk of side effects.

What are the most significant drug interactions with cefdinir?

Important drug interactions to be aware of include:

• Probenecid: May increase cefdinir levels in the body
• Iron supplements: Can reduce the absorption of cefdinir
• Antacids containing magnesium or aluminum: May decrease cefdinir absorption
• Oral contraceptives: Cefdinir may reduce the effectiveness of birth control pills
• Blood thinners: Cefdinir may increase the risk of bleeding when used with anticoagulants

Always provide your healthcare provider with a complete list of all medications, supplements, and herbal products you are taking to avoid potential interactions.

Strategies to Minimize Cefdinir Side Effects

While some side effects of cefdinir may be unavoidable, there are steps you can take to minimize their occurrence and severity.

How can patients reduce the risk of experiencing side effects from cefdinir?

To minimize side effects when taking cefdinir:

1. Take the medication with food to reduce stomach upset
2. Stay well-hydrated to help prevent diarrhea and other gastrointestinal issues
3. Avoid taking cefdinir with iron supplements or antacids containing magnesium or aluminum
4. Consider taking a probiotic supplement to maintain healthy gut bacteria
5. Follow the prescribed dosage and duration of treatment exactly as directed
6. Report any unusual or severe side effects to your healthcare provider promptly

By following these strategies and maintaining open communication with your healthcare provider, you can help ensure a safer and more comfortable experience while taking cefdinir.

Cefdinir Interactions Checker – Drugs.com

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There are 45 drugs known to interact with
cefdinir, along with
7 disease interactions, and 1 alcohol/food interaction.

Of the total drug interactions,
3 are major, and 42 are moderate.

Does cefdinir interact with my other drugs?

Enter other medications to view a detailed report.

• View all 45 medications that may interact with cefdinir
• View cefdinir alcohol/food interactions (1)
• View cefdinir disease interactions (7)

Most frequently checked interactions

View interaction reports for cefdinir and the medicines listed below.

• Major
• Moderate
• Minor
• Unknown

• Aspirin Low Strength (aspirin)
• Augmentin (amoxicillin / clavulanate)
• Benadryl (diphenhydramine)
• Claritin (loratadine)
• CoQ10 (ubiquinone)
• Cymbalta (duloxetine)
• Eliquis (apixaban)
• Fish Oil (omega-3 polyunsaturated fatty acids)
• Flexeril (cyclobenzaprine)
• Flonase (fluticasone nasal)
• Lyrica (pregabalin)
• Metoprolol Succinate ER (metoprolol)
• Metoprolol Tartrate (metoprolol)
• MiraLAX (polyethylene glycol 3350)
• Mucinex (guaifenesin)
• Norco (acetaminophen / hydrocodone)
• ProAir HFA (albuterol)
• Probiotic Formula (bifidobacterium infantis / lactobacillus acidophilus)
• Protonix (pantoprazole)
• Singulair (montelukast)
• Symbicort (budesonide / formoterol)
• Synthroid (levothyroxine)
• Tylenol (acetaminophen)
• Vitamin B12 (cyanocobalamin)
• Vitamin C (ascorbic acid)
• Vitamin D2 (ergocalciferol)
• Vitamin D3 (cholecalciferol)
• Xanax (alprazolam)
• Zofran (ondansetron)
• Zyrtec (cetirizine)

Cefdinir alcohol/food interactions

There is 1 alcohol/food interaction with cefdinir.

Cefdinir disease interactions

There are 7 disease interactions with cefdinir which include:

• colitis
• renal dysfunction
• diabetes
• nitroprusside tests
• dialysis
• liver disease
• seizure disorders

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• Compare alternatives
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• Reviews (382)
• Drug images
• Side effects
• Dosage information
• Patient tips
• During pregnancy
• Support group
• Drug class: third generation cephalosporins
• Breastfeeding
• En español

Related treatment guides

• Bacterial Infection
• Otitis Media
• Pneumonia
• Bronchitis

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.

Major	Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate	Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor	Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown	No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Cefdinir side effects and how to avoid them

Diarrhea, yeast infection, and headache are common cefdinir side effects, but this antibiotic can also cause a rash and C.Diff

Common cefdinir side effects | Diarrhea | Yeast infection | Serious side effects | Rash | C.Diff | Side effects in seniors | How long do side effects last? | Warnings | Interactions | How to avoid side effects

Cefdinir (brand name: Omnicef) is a third-generation cephalosporin antibiotic used to treat certain bacterial infections such as bronchitis, sinusitis, pharyngitis (sore throat), and urinary tract infections (UTIs). It works by killing harmful bacteria throughout the body. It comes in both capsule and oral suspension form and is usually taken for up to 10 days, depending on the type of infection being treated.

Common side effects include diarrhea, vomiting, and headache. Serious adverse reactions are less common and include severe allergic reactions, Steven-Johnson’s syndrome, and Clostridium difficile (C. difficile) infections. Drug interactions are also possible when taking cefdinir. Be sure to tell your healthcare provider if you have any medical conditions or are taking any medications before taking cefdinir.

RELATED: Learn more about cefdinir |Get cefdinir discounts

Common side effects of cefdinir

The most common side effects of cefdinir include:

• Diarrhea 
• Yeast infection (candidiasis) 
• Nausea and/or vomiting
• Headache
• Abdominal pain
• Inflammation of the vagina (vaginitis)
• Rash 
• Indigestion/Flatulence

Some clinically significant laboratory changes that might be seen include:

• Increased white blood cells in urine 
• Increased levels of protein in the urine (proteinuria)
• Microscopic amounts of blood in the urine (microhematuria) 
• Increased blood sugar (glucose)
• High levels of eosinophils (eosinophilia), which are a special type of white blood cells
• Elevated liver enzymes i. e. alanine aminotransferase (ALT) or aspartate aminotransferase (AST)

Diarrhea

In the same adult clinical trial mentioned above, 15% of adults and adolescents experienced diarrhea. 

The pediatric clinical trial showed 8% of children being treated with cefdinir experienced diarrhea and 0.8% experienced abdominal pain. The rates of diarrhea were highest in patients younger than 2 years old (17%).

If diarrhea is severe during treatment with cefdinir, consult your healthcare provider to rule out a C. difficile infection.

Yeast infection

Cefdinir destroys harmful bacteria in the body, but can also destroy the good bacteria. This may result in oral thrush and vaginal yeast infections during treatment with cefdinir. 

A clinical trial of 5,093 adults and adolescents taking 600 mg of cefdinir per day found that 4% of women experienced a vaginal yeast infection during treatment. In the same group, there was a 0.2% occurrence of yeast infections unrelated to the vagina.

Another trial of 2,289 pediatric patients showed vaginal yeast infections in 0.3% of girls being treated with cefdinir and fungal skin infections in 0.9% of all children.

RELATED: How to prevent yeast infections from antibiotics

Serious side effects of cefdinir

Serious side effects while taking cefdinir are rare but possible. These side effects include:

• Severe allergic reaction (anaphylaxis)
• Stevens-Johnson syndrome: flu-like symptoms accompanied by painful rash and blisters
• Toxic epidermal necrolysis: a rare condition causing skin peeling and blistering
• Exfoliative dermatitis: redness and peeling of large areas of skin
• C. difficile infection causing severe diarrhea and colitis
• Low neutrophils (neutropenia)
• Low platelet count (thrombocytopenia)
• Hemolytic anemia
• Aplastic anemia
• A severe immune reaction (serum sickness)
• Renal toxicity
• Liver toxicity

Cefdinir rash

Several side effects of cefdinir may be accompanied by a rash, including an allergic reaction, Stevens-Johnson syndrome, toxic epidermal necrolysis, and exfoliative dermatitis.

Clinical trials reported rash at an incidence of 0.9% in adults and adolescents being treated with cefdinir. Rash occurred in 3% of children taking this medication, although the majority of these occurrences were in children younger than 2 years old.

Seek emergency medical attention right away if rash-like symptoms are accompanied by wheezing, tightness in the chest or throat, or trouble breathing. This could be a sign of a potentially dangerous allergic reaction.

Clostridium difficile-associated diarrhea

Treatment with Cefdinir can destroy some of the bacteria in the gut. This allows other organisms such as C. difficile to grow out of control. C. difficile produces toxins that may cause swelling/inflammation in the lining of the large intestine. This inflammation is called pseudomembranous colitis. This can cause diarrhea ranging in severity from mild diarrhea to fatal colitis. Symptoms include:

• Frequent watery diarrhea that is sometimes bloody
• Pain and tenderness in the stomach
• Cramping
• Nausea
• Fever
• Loss of appetite

RELATED: Antibiotics that cause C. Difficile

Cefdinir side effects in elderly

People with multiple comorbidities may have an increased risk of side effects when treated with antibiotics, and older adults have more underlying health conditions than younger patients. However, clinical trials found cefdinir to be a safe drug for older patients, with a lower adverse reaction rate compared to young adults.

How long do cefdinir side effects last?

Most cefdinir side effects will subside during or shortly after treatment, although some may require medical attention. Yeast infections, oral thrush, and C. difficile are some examples of side effects that may need to be treated with other medications.

Severe allergic reactions require immediate medical attention. Signs of a severe allergic reaction include:

• Rash or hives
• Swollen or blistered areas of skin
• Red, peeling skin
• Wheezing
• Chest tightness
• Swelling of the mouth, face, lips, throat, or tongue
• Difficulty breathing

Cefdinir contraindications and warnings

Cefdinir may not be appropriate for everyone. Discuss any medical conditions with your healthcare provider before starting treatment, especially if you have ever had:

• Kidney disease or a history of dialysis
• Allergies to other antibiotics, especially cephalosporins and penicillins
• Colitis
• Diabetes (oral suspension contains sucralose)
• Seizure disorders

Kidney disease

Use caution in patients with a creatinine clearance of <30mL/min. Dosage should be reduced in these patients with kidney problems. There is evidence that cephalosporin antibiotics may cause seizures in patients with renal impairment whose dosage was not reduced.

Colitis

Use caution in patients with a history of colitis. Clostridium difficile-associated diarrhea may be more severe in these patients if it occurs. 

Diabetes

Cefdinir can increase blood sugar on its own. The liquid form of cefdinir also contains sugar, which may alter blood glucose levels. Diabetic patients should avoid using cefdinir suspension to ensure that blood sugar levels aren’t altered during treatment. Careful glucose monitoring is required when Cefdinir must be used.

Withdrawal

Cefdinir does not cause dependency or withdrawal symptoms. However, like all antibiotics, if a patient does not finish the full course of antibiotics, an infection may persist or recur.

Overdose

Overdose on any medication is possible, including cefdinir. Signs of overdose include:

• Nausea
• Vomiting
• Stomach pain
• Diarrhea
• Seizures

If an overdose is suspected, seek emergency medical attention or call the Poison Control Center immediately. 

Children

Cefdinir is FDA-approved to treat certain bacterial infections in children as young as 2 months. It may treat bacterial ear infections (otitis media), sinusitis, pharyngitis, tonsillitis, pneumonia, and bacterial skin infections.

Pregnancy

According to the FDA, cefdinir is a pregnancy category B medication. There is no human data available to measure risk, but animal data shows no known risks or complications of taking cefdinir while pregnant. If you’re pregnant, be sure to talk to your healthcare provider about the risks before taking this medication.

Breastfeeding

Cefdinir may be taken while breastfeeding. There is no human data available to determine the risk to the infant, however, no risk is expected based on data from other cephalosporin antibiotics. It is not yet known if cefdinir affects breast milk production.

Cefdinir interactions

There are several drugs and supplements that may interact with cefdinir, according to the FDA. Be sure to tell your healthcare provider what medications, vitamins, and supplements you’re taking before beginning treatment.

• Antacids, magnesium, and iron supplements: Some antacids or supplements containing iron or magnesium may interfere with cefdinir absorption. Take 2 hours before or after Cefdinir. Patients taking iron may also experience a reddish stool discoloration (not related to bleeding). The reddish color is due to the formation of a complex between cefdinir and iron in the gut.
• Probenecid: Taking probenecid, a uric acid reducer that treats gout, may increase levels of cefdinir in the body.
• Hormonal contraceptives: Cefdinir may decrease the efficacy of hormonal birth control; use another form of birth control while taking cefdinir.
• Tetracyclines: Taking tetracyclines with cefdinir may alter the way cefdinir works inside the body.

How to avoid cefdinir side effects

Cefdinir may cause side effects, but there are ways to reduce the risk for these undesired effects. Some ways to avoid side effects while taking cefdinir include:

• Take cefdinir as directed. Follow the medical advice of your healthcare provider and instructions given by your pharmacist. Be sure to shake your liquid cefdinir before use and measure using an appropriate dosing syringe.
• Take cefdinir with or without food. You don’t have to take cefdinir with food, however, taking it with food may decrease stomach discomfort.
• Don’t skip doses. If you forget a dose of cefdinir, take the missed dose as soon as possible. If it’s almost time for your next dose, skip the missed dose. Never double up on doses, as this may cause unwanted side effects.
• Avoid antacids, magnesium, and iron supplements for at least two hours before and after taking cefdinir. Some antacids and supplements interfere with the absorption of cefdinir. Avoid taking antacids or supplements containing magnesium or iron within two hours of taking cefdinir to prevent these interactions.
• Tell your provider about all medical conditions. Cefdinir may not be the best medication for patients with certain medical conditions. Avoid taking cefdinir if you’ve had an allergic reaction to cephalosporin antibiotics in the past.
• Tell your provider what other medications you are taking. Drug interactions while taking cefdinir are possible. Tell your healthcare provider of any prescription drugs, over-the-counter medications, supplements, and herbal products before beginning treatment.
• Don’t stop taking cefdinir before you’ve finished treatment unless directed to do so by a healthcare professional. It’s important to finish your entire treatment, even if your symptoms improve. Discontinuing the medication early may cause repeat infection or antibiotic resistance.
• Store cefdinir properly. Keep this medication at room temperature away from moisture and heat and out of reach of children. Discard your unused cefdinir after treatment.

Resources

• Omnicef drug information, Federal Drug Administration (FDA)
• Cefdinir adverse reactions, Epocrates
• Cefdinir contraindications, Epocrates
• Cefdinir drug label info, DailyMed

Rinicef ​​300mg/ Rinicef ​​300mg

Trade name: Rinicef

International Nonproprietary Name: Cefdinir/Cefdinir

Presentation: capsules 300 mg.

Description: hard gelatin capsules, black opaque cap and gray opaque base.

Composition:

1 capsule contains:

active substance : cefdinir – 300.00 mg;

Pharmacotherapeutic group

Antibacterial agents for systemic use. Third generation cephalosporins. ATX code: J01DD15

Pharmacological properties.

Pharmacodynamics

The active substance cefdinir is a semi-synthetic broad-spectrum cephalosporin antibiotic of the third generation for oral administration. Like other antibiotics of the cephalosporin group, cefdinir has a bactericidal effect against susceptible microorganisms due to the inhibition of the synthesis of peptidoglycan of the bacterial cell wall by disrupting the final stage of transamination necessary for the formation of cross-links. Cefdinir is resistant to many, but not all, beta-lactamases produced by Gram-positive and Gram-negative bacteria. Due to this, many microorganisms resistant to penicillins and some cephalosporins are sensitive to cefdinir. The spectrum of action of cefdinir includes:

Aerobic Gram-positive microorganisms

Staphylococcus aureus (including beta-lactamase producing strains)

Staphylococcus pneumoniae
(only strains sensitive to penicillin)

Staphylococcus pyogenes

Aerobic gram-negative microorganisms

Haemophilus influenzae (including beta-lactamase producing strains)

Haemophilus parainfluenzae
(including beta-lactamase producing strains)

Moraxella catarrhalis (including beta-lactamase producing strains)

The following data was obtained in vitro , but their clinical significance is unknown.

Minimum inhibitory concentration (MIC) of cefdinir in in vitro
is 1 μg / ml or less in relation to (≥ 90%) strains of the following microorganisms; however, the safety and efficacy of cefdinir in the treatment of infections caused by the following microorganisms has not been demonstrated in clinical studies.

Aerobic gram-positive microorganisms

Staphylococcus epidermidis

Streptococcus agalactiae

Streptococcus viridans group

Aerobic gram-negative microorganisms

Citrobacter diversus

Escherichia coli

Klebsiela pneumoniae

Proteus mirabilis

Cefdinir is inactive against strains Pseudomonas, Enterobacter, Enterococcus and methicillin-resistant strains of staphylococci.

Method of administration and dosage

Recommended dosages and duration of treatment for infections in adults and adolescents are described in the table below. The total daily dose for the treatment of all infections is 600 mg. Dosing the drug once a day for 10 days is as effective as taking it twice a day. Once-daily dosing has not been studied for the treatment of pneumonia and skin infections, so Rinicef ​​should be taken twice daily in these cases. The capsules can be taken with or without food.

For the treatment of children (6 months – 12 years), cefdinir is used in the form of a suspension.

Adults and adolescents (ages 13 and over)

Elderly patients: does not require a change in dosing regimen, unless there is a significant impairment of renal function (CC < 30 ml / min). If CC < 30 ml / min, the drug should be taken at a dose of 300 mg once a day.

Patients with renal insufficiency

For patients with CC < 30 ml/min, cefdinir should be given at a dose of 300 mg once daily.

Hemodialysis patients

Hemodialysis promotes the elimination of cefdinir from the body. For patients on permanent hemodialysis, the recommended starting dose is 300 mg or 7 mg/kg every other day. At the end of each hemodialysis session, 300 mg (or 7 mg/kg) of cefdinir is given. Subsequent doses (300 mg or 7 mg/kg) are then given every other day.

If you miss the next dose of the drug, you should take it as soon as you remember. If this missed dose occurs at the time of the next dose, skip the missed dose and follow the previous dosing regimen, do not double the dose.

Side effect

Cefdinir is well tolerated, the identified adverse reactions were mild in nature and resolved spontaneously after discontinuation. Most withdrawals were associated with gastrointestinal disturbances, mainly manifested by diarrhea or nausea. In rare cases, the withdrawal of the drug was due to the development of a rash while taking cefdinir.

Adverse reactions are classified according to the frequency of occurrence: very often (? 1/10), often (from ? 1/100 to < 1/10), infrequently (from ? 1/1,000 to < 1/100), rarely (? 1/10,000, <1/1000), very rarely (< 1/10,000), and the frequency is unknown (the frequency cannot be established according to the available data).

Very common: diarrhea, rash, nausea.

Often: skin candidiasis, abdominal pain, leukopenia, candidal vaginitis, vaginitis, stool changes, dyspepsia, hyperkinesis, macolopapular rash, nausea, increased AST.

Adverse reactions specific to cephalosporins

Allergic reactions, anaphylaxis, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, renal dysfunction, toxic nephropathy, liver dysfunction including cholestasis, aplastic anemia, hemolytic anemia, hemorrhagic disorders, false positive urine glucose test, neutropenia, pancytopenia and agranulocytosis. Pseudomembranous colitis can develop both during and after the end of the antibiotic prescription.

The use of some cephalosporins was accompanied by the development of seizures, especially in patients with impaired renal function, who were not dose recalculated. If convulsions develop during therapy, the antibiotic should be discontinued. If clinically necessary, anticonvulsant therapy may be prescribed.

According to the results of post-registration experience of use, the following adverse reactions were identified: shock, anaphylaxis (in rare cases with a fatal outcome), edema of the subglottic space and face, feeling of suffocation, serum-like syndrome, conjunctivitis, stomatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis, erythema multiforme, erythema nodosum, acute hepatitis, cholestatic syndrome, lightning nasal hepatitis, liver failure, jaundice, amylase elevation, acute enterocolitis, hemorrhagic diarrhea, hemorrhagic colitis, melena, pseudomembranous colitis, pancytopenia, granulocytopenia, leukopenia, thrombocytopenia, idiopathic thrombocytopenic purpura, hemolytic anemia, acute respiratory failure, asthma attack, drug-induced pneumonia, eosinophilic pneumonia, idiopathic interstitial pneumonia, fever, acute renal failure, nephropathy, bleeding tendency, bleeding disorder, generalized thrombohemorrhagic syndrome, upper gastrointestinal bleeding, peptic ulcer, intestinal obstruction, unconsciousness, allergic vasculitis, possible cefdinir-diclofenac interaction, heart failure, chest pain, myocardial infarction, rhabdomyolysis, involuntary movements, hypertension.

In the event of the listed adverse reactions, as well as a reaction not indicated in the instructions for use, you should consult a doctor.

Contraindications

Rinicef ​​is contraindicated in patients with a history of allergy to the cephalosporin class of antibiotics and hypersensitivity to excipients in the composition of the drug.

Overdose

Data on cefdinir overdose in humans are not available.

In acute toxicity studies in rodents, a single oral dose of cefdinir at a dose of 5600 mg/kg did not lead to the development of adverse reactions. The following signs and symptoms of overdose have been observed with other beta-lactam antibiotics: nausea, vomiting, stomach discomfort, diarrhea, and convulsions.

During hemodialysis, cefdinir is removed from the body, which can be useful in case of serious toxic reactions caused by overdose, especially if the patient has impaired renal function.

Precautions

Before starting therapy with Rinicef, it is necessary to exclude the presence of a history of hypersensitivity reactions to penicillins, cephalosporins or other drugs.

In case of suspicion or confirmation of the development of Clostridium difficile -associated diarrhea, antibiotic therapy should be discontinued if it does not work on Clostridium difficile . Based on the clinical condition, the patient may be indicated for fluid replacement, administration of electrolyte and amino acid solutions, antibiotic therapy. Clostridium difficile

Rinicef, like other broad-spectrum antimicrobials (antibiotics), should be used with caution in patients with a history of colitis.

In patients with transient or persistent renal insufficiency (CC <30 ml/min), the daily dose of Rinicef ​​should be reduced, since administration at the recommended doses can lead to a significant increase in plasma concentrations and the half-life of cefdinir.

The administration of cephalosporins can sometimes lead to a positive Coombs test result.

Use during pregnancy and lactation.

Pregnancy and childbirth

Experimental reproduction studies have shown the absence of any teratogenic effect.

Data on the results of the use of cefdinir in pregnant women are not available. Cefdinir should only be used during pregnancy if there is a justified clinical need.

Data on the effect of the appointment of cefdinir on childbirth are not available.

Lactation

When prescribing cefdinir at a dose of 600 mg, it is not detected in breast milk in nursing mothers. Cefdinir is prescribed during lactation only after a careful assessment of the benefit / risk ratio for mother and child.

Influence on the ability to drive vehicles and work with mechanisms.

Rincef does not affect the ability to drive vehicles and work with mechanisms.

Interaction with other drugs

Co-administration of cefdinir and an antacid results in a decrease in the rate (C _max ) and extent (AUC) of cefdinir absorption by approximately 40%. If antacids are required during treatment with Rinicef, Rinicef ​​should be taken at least 2 hours before or 2 hours after taking the antacid.

As with other beta-lactam antibiotics, probenicide interferes with renal excretion of cefdinir when administered concomitantly, resulting in an approximately two-fold increase in AUC, a 54% increase in maximum cefdinir plasma concentration, and a prolongation of the half-life t _1/2 by 50%.

The simultaneous administration of cefdinir with iron-containing drugs containing 60 mg of elemental iron (as FeSO ₄ ), or vitamin drugs containing 10 mg of iron, reduces the absorption of cefdinir by 80% and 31%, respectively. If a patient requires iron medications during cefdinir therapy, Rinicef ​​should be taken at least 2 hours before or after taking iron medications.

There have been reports of reddish-colored stools in patients taking cefdinir. In many cases, iron-fortified foods were taken concomitantly by these patients. The reddish coloration may be due to the formation in the gastrointestinal tract of a non-absorbable complex of cefdinir or its degradation products and iron.

During treatment with cefdinir, false-positive results for urinary ketones may occur with nitroprusside, but not with nitroferricyanide. False-positive results may also be noted when determining glucose in the urine using Benedict’s solution or Fehling’s reagent (it is recommended to determine glycosuria only by the enzyme method). The use of cephalosporins can sometimes lead to a positive Coombs test result.

Storage conditions and shelf life

At a temperature not higher than 25°C.

Keep out of the reach of children!

Shelf life 3 years. Do not use after the expiry date stated on the packaging.

Holiday conditions

By prescription.

Packaging

10 capsules in a blister pack made of PVC film and flexible packaging based on aluminum foil.

1 or 2 blister packs, together with the leaflet, are placed in a cardboard pack.

Manufacturer information

Foreign production and trade unitary enterprise “Reb-Pharma”, 223216, Republic of Belarus, Minsk region, Chervensky district, settlement. Smilovichi, st. Sadovaya, 1, tel./fax: (+375) 17 240 26 35, e-mail: [email protected], http://www.rebpharma.by.

3-Dinir capsules 300 mg blister #10

3-Dinir capsules are indicated for the treatment of mild to moderate infections caused by cefdinir-susceptible strains of microorganisms: ophilus parainfluenzae (including β-lactamase producing strains), Streptococcus pneumoniae (penicillin-susceptible strains only), and Moraxella catarrhalis (including β-lactamase producing strains). Exacerbation of chronic bronchitis caused by Haemophilus influenzae (including β-lactamase producing strains), Haemophilus parainfluenzae (including β-lactamase producing strains), Streptococcus pneumoniae (penicillin-susceptible strains only), and Moraxella catarrhalis (including β-lactamase producing strains). Acute sinusitis due to Haemophilus influenzae (including strains producing β-lactamase), Streptococcus pneumoniae (only penicillin-sensitive strains) and Moraxella catarrhalis (including strains producing β-lactamase). Pharyngitis/tonsillitis due to Streptococcus pyogenes. Cefdinir is effective in the treatment of S.pyogenes in the oropharynx. However, there are no data on the use of cefdinir for the prevention of rheumatic fever after S. pyogenes pharyngitis/tonsillitis. Skin and soft tissue infections caused by Staphylococcus aureus (including β-lactamase producing strains) and Streptococcus pyogenes.

Composition

Active ingredient: cefdinir;

1 capsule contains: cefdinir in terms of dry matter – 300 mg;

Excipients: calcium carboxymethylcellulose, polyethylene glycol (macrogol) stearate, colloidal anhydrous silica, magnesium stearate.

Composition of the capsule shell: black iron oxide (E 172), titanium dioxide (E 171), gelatin.

Contraindications

Hypersensitivity to cefdinir or any other cephalosporin antibiotic.

Directions for use

The preparation in the form of capsules is intended for use by adults and adolescents from 13 years of age.

The total daily dose for all infections is 600 mg. The dosage once a day for 10 days is as effective as the dosage 2 times a day. Dosage once daily has not been studied in pneumonia and skin infections. Therefore, in these infections, the drug 3-Dinir should be taken 2 times a day. The drug can be used regardless of the meal.

Application considerations

Pregnant women

Cefdinir should only be used during pregnancy if there is a reasonable clinical need. The effect of prescribing cefdinir on labor has not been studied.

Children

Cefdinir capsules are not intended for use in children under 13 years of age.

Drivers

Experience with cefdinir has not shown an adverse effect on the ability to drive and use machines.

Overdose

There are no data on overdose of cefdinir in humans. In acute toxicity studies in rodents, a single oral dose of cefdinir at a dose of 5600 mg/kg did not result in any adverse reactions. Toxic signs and symptoms in overdose of other β-lactam antibiotics include nausea, vomiting, epigastric distress, diarrhea, and convulsions. During hemodialysis, cefdinir is removed from the body, which may be useful in case of serious toxic reactions caused by overdose, especially if the patient’s kidney function is impaired.

Side effects

from the gastrointestinal tract: dry oral mucosa, stomatitis, flatulence, abdominal pain, nausea, diarrhea, stool disturbance, dyspepsia, pseudoemembranous colitis, acute enterocolitis, hemorrhagic colitis, hemorrhagic diarrhea, intestinal impassivity, constipation, surgur anorexia, ulcer, Melena. From the respiratory system: feeling of suffocation, acute respiratory failure, induced pneumonia, asthma attack, eosinophilic pneumonia, idiopathic interstitial pneumonia. From the side of the central nervous system: headache, insomnia, drowsiness, dizziness, loss of consciousness, convulsions, hyperkinesia, involuntary movements and rhabdomyolysis. On the part of the blood and lymphatic system: blood coagulation disorders (disseminated intravascular coagulation syndrome), granulocytopenia, neutropenia, transient leukopenia, thrombocytopenia, pancytopenia and agranulocytosis, aplastic anemia, idiopathic thrombocytopenic purpura, hemolytic anemia, hemorrhage. On the part of the immune system: serum syndrome, anaphylactic shock (in rare cases, fatal). From the hepatobiliary system: liver failure, acute hepatitis, fulminant hepatitis, impaired liver function, including cholestasis, jaundice. From the urinary system: impaired renal function, toxic nephropathy, acute renal failure, nephropathy. Allergic reactions: rash, pruritus, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, anaphylactic reactions, maculopapular rash, allergic vasculitis, exfoliative dermatitis, erythema nodosum, toxic epidermal necrolysis, laryngeal and facial edema, shock, conjunctivitis, fever. On the part of biochemical indicators: increased ACT, increased blood amylase, false-positive test for glucose in the urine. Effects due to biological action: itching, leucorrhoea, skin candidiasis, vaginal candidiasis, vaginitis. Others: bleeding tendency, bleeding and hemorrhage, chest pain, arterial hypertension, asthenia.

Interactions

Reddish stools have been reported in patients treated with cefdinir. In many cases, these patients were also taking iron-fortified foods at the same time. The appearance of a red color may be due to the formation in the gastrointestinal tract of an unabsorbed complex of cefdinir or its degradation products with iron.

Storage conditions

Store in the original container at a temperature not exceeding 25°C.