What is the proper dosage of celecoxib for osteoarthritis. How should celecoxib be taken for rheumatoid arthritis. What is the recommended dose of Celebrex for acute pain. How do you adjust celecoxib dosage for patients with liver impairment.

Understanding Celecoxib and Its Uses

Celecoxib, marketed under the brand name Celebrex, is a nonsteroidal anti-inflammatory drug (NSAID) belonging to the class of Cox-2 inhibitors. It is widely prescribed for various conditions characterized by pain and inflammation. The Food and Drug Administration (FDA) has approved celecoxib for treating several conditions in adults, including:

• Acute pain (short-term pain)
• Osteoarthritis
• Rheumatoid arthritis
• Ankylosing spondylitis
• Dysmenorrhea (period pain and menstrual cramps)

Additionally, celecoxib is FDA-approved for treating juvenile rheumatoid arthritis in children aged 2 years and older. As with any medication, it’s crucial to understand the proper dosage and administration to ensure safe and effective treatment.

General Dosing Guidelines for Celecoxib

When prescribing celecoxib, healthcare providers follow a general principle: use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals. This approach helps minimize the risk of adverse effects while still providing therapeutic benefits.

Can celecoxib be taken with or without food? Celecoxib doses can be administered without regard to the timing of meals, offering flexibility for patients.

The medication is available in oral capsule form in several strengths: 50 mg, 100 mg, 200 mg, and 400 mg. This variety allows for precise dosing tailored to each patient’s needs and condition.

Celecoxib Dosage for Osteoarthritis

For patients with osteoarthritis, the recommended dosage of celecoxib is 200 mg per day. This can be administered in two ways:

• As a single 200 mg dose once daily
• As 100 mg twice daily

The choice between these two regimens may depend on the patient’s preference and response to treatment. Some patients may find that splitting the dose provides more consistent pain relief throughout the day.

Dosing for Rheumatoid Arthritis

How much celecoxib should be taken for rheumatoid arthritis? For patients with rheumatoid arthritis, the recommended dosage range is 100 mg to 200 mg twice daily. The specific dose within this range is typically determined based on the severity of symptoms and the patient’s response to treatment.

It’s important to note that higher doses may increase the risk of side effects, so healthcare providers often start with the lower dose and adjust as needed.

Celecoxib for Acute Pain and Dysmenorrhea

For the management of acute pain and treatment of primary dysmenorrhea, celecoxib follows a slightly different dosing regimen:

1. Initial dose: 400 mg
2. Additional dose if needed on the first day: 200 mg
3. Subsequent days: 200 mg twice daily as needed

This loading dose approach aims to provide rapid pain relief, followed by a maintenance dose to manage ongoing pain.

Dosage Adjustments for Special Populations

Certain patient groups may require dosage adjustments to ensure safe and effective use of celecoxib:

Patients with Hepatic Impairment

How should celecoxib dosage be adjusted for patients with liver problems? For patients with moderate hepatic impairment (Child-Pugh Class B), the recommended approach is to reduce the dose by 50%. This adjustment helps compensate for the reduced ability to metabolize the drug.

It’s important to note that celecoxib is not recommended for use in patients with severe hepatic impairment due to the increased risk of adverse effects.

Poor Metabolizers of CYP2C9 Substrates

Some individuals may be poor metabolizers of CYP2C9 substrates, which affects how their body processes celecoxib. For adult patients who are known or suspected to be poor CYP2C9 metabolizers, the recommendation is to initiate treatment with half of the lowest recommended dose.

This cautious approach helps prevent excessive drug accumulation in the body. For children with juvenile rheumatoid arthritis who are known or suspected to be poor CYP2C9 metabolizers, healthcare providers may consider alternative treatments.

Administration Tips for Celecoxib

While celecoxib is typically taken as a whole capsule, some patients may have difficulty swallowing capsules. For these individuals, an alternative administration method is available:

1. Carefully empty the contents of a celecoxib capsule onto a level teaspoon of cool or room temperature applesauce.
2. Ingest the mixture immediately with water.
3. Do not chew the mixture.

Is there a time limit for consuming celecoxib mixed with applesauce? The sprinkled capsule contents on applesauce remain stable for up to 6 hours under refrigerated conditions (2째C to 8째C/35째F to 45째F). However, it’s best to consume the mixture immediately for optimal efficacy.

Monitoring and Adjusting Celecoxib Treatment

As with any medication, the effectiveness and safety of celecoxib treatment should be monitored regularly. Healthcare providers may adjust the dosage based on the patient’s response and any side effects experienced.

For certain conditions, such as ankylosing spondylitis, if no effect is observed after 6 weeks of treatment at the standard dose (200 mg daily), a trial of 400 mg daily may be considered. However, if no response is seen after 6 weeks at this higher dose, alternative treatment options should be explored.

It’s crucial for patients to communicate openly with their healthcare providers about their symptoms, any side effects, and overall response to treatment. This ongoing dialogue helps ensure that the celecoxib dosage remains appropriate and effective over time.

Are there any long-term considerations for celecoxib use? As with all NSAIDs, long-term use of celecoxib should be carefully monitored due to potential risks associated with prolonged use, such as cardiovascular and gastrointestinal effects. Regular check-ups and potentially periodic blood tests may be recommended to ensure safe continued use.

In conclusion, celecoxib (Celebrex) offers a valuable treatment option for various pain and inflammatory conditions. By following proper dosing guidelines and making necessary adjustments for special populations, healthcare providers can help patients achieve optimal pain relief while minimizing the risk of adverse effects. As always, patients should adhere to their prescribed dosage and consult their healthcare provider before making any changes to their treatment regimen.

Celebrex Dosage Guide – Drugs.com

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Generic name: CELECOXIB 50mg
Dosage form: capsule
Drug class: Cox-2 inhibitors

Medically reviewed by Drugs.com. Last updated on Sep 29, 2021.

General Dosing Instructions

Carefully consider the potential benefits and risks of CELEBREX and other treatment options before deciding to use CELEBREX. Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals [see Warnings and Precautions (5)].

These doses can be given without regard to timing of meals.

Osteoarthritis

For OA, the dosage is 200 mg per day administered as a single dose or as 100 mg twice daily.

Rheumatoid Arthritis

For RA, the dosage is 100 mg to 200 mg twice daily.

Juvenile Rheumatoid Arthritis

For JRA, the dosage for pediatric patients (age 2 years and older) is based on weight. For patients ≥10 kg to ≤25 kg the recommended dose is 50 mg twice daily. For patients >25 kg the recommended dose is 100 mg twice daily.

For patients who have difficulty swallowing capsules, the contents of a CELEBREX capsule can be added to applesauce. The entire capsule contents are carefully emptied onto a level teaspoon of cool or room temperature applesauce and ingested immediately with water. The sprinkled capsule contents on applesauce are stable for up to 6 hours under refrigerated conditions (2°C to 8°C/35°F to 45°F).

Ankylosing Spondylitis

For AS, the dosage of CELEBREX is 200 mg daily in single (once per day) or divided (twice per day) doses. If no effect is observed after 6 weeks, a trial of 400 mg daily may be worthwhile. If no effect is observed after 6 weeks on 400 mg daily, a response is not likely and consideration should be given to alternate treatment options.

Management of Acute Pain and Treatment of Primary Dysmenorrhea

For management of Acute Pain and Treatment of Primary Dysmenorrhea, the dosage is 400 mg initially, followed by an additional 200 mg dose if needed on the first day. On subsequent days, the recommended dose is 200 mg twice daily as needed.

Special Populations

Hepatic Impairment

In patients with moderate hepatic impairment (Child-Pugh Class B), reduce the dose by 50%. The use of CELEBREX in patients with severe hepatic impairment is not recommended [see Warnings and Precautions (5.3), Use in Specific Populations (8.6), and Clinical Pharmacology (12.3)].

Poor Metabolizers of CYP2C9 Substrates

In adult patients who are known or suspected to be poor CYP2C9 metabolizers based on genotype or previous history/experience with other CYP2C9 substrates (such as warfarin, phenytoin), initiate treatment with half of the lowest recommended dose.

In patients with JRA who are known or suspected to be poor CYP2C9 metabolizers, consider using alternative treatments [see Use in Specific populations (8.8) and Clinical Pharmacology (12.5)].

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Medical Disclaimer

Form, strengths, how to take, and more

Celebrex (celecoxib) is a brand-name prescription medication. The Food and Drug Administration (FDA) has approved it to treat the following in adults:

• acute pain (short-term pain)
• osteoarthritis
• rheumatoid arthritis
• ankylosing spondylitis
• dysmenorrhea (period pain and menstrual cramps)

In addition, Celebrex is FDA-approved to treat juvenile rheumatoid arthritis in children ages 2 years and older.

Celebrex comes as an oral capsule. It belongs to a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). Celebrex is available in generic form as the drug celecoxib.

For information about the dosage of Celebrex, including its strengths and how to take the drug, keep reading. For a comprehensive look at Celebrex, see this article.

This article describes typical dosages for Celebrex provided by the drug’s manufacturer. When taking Celebrex, always follow the dosage prescribed by your doctor.

Before you start treatment with Celebrex, your doctor will talk with you about the dosage that’s right for you.

Celebrex form

Celebrex comes as an oral capsule.

Celebrex strengths

Celebrex is available in the following strengths: 50 milligrams (mg), 100 mg, 200 mg, and 400 mg.

Typical dosages

The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosing schedule to fit your needs.

The maximum dose of Celebrex depends on the condition being treated. In general, the highest dosage of Celebrex that doctors prescribe is 400 mg per day. The typical dosages of Celebrex are described below.

Dosage for acute pain, such as back pain

For acute pain, such as back pain, the first dose of Celebrex is typically 400 mg. Your doctor may recommend taking an additional 200 mg on your first day of treatment if you need it. After the first day, the usual dosage is 200 mg twice per day, if needed.

Dosage for osteoarthritis

The recommended dosage of Celebrex for osteoarthritis is 200 mg per day. This can be taken as 200 mg once per day or 100 mg twice per day.

Dosage for rheumatoid arthritis

The recommended dosage of Celebrex for rheumatoid arthritis is 100 mg to 200 mg twice per day.

Dosage for ankylosing spondylitis

For ankylosing spondylitis (AS), your doctor will likely recommend a Celebrex dosage of 200 mg per day. This can be taken as 200 mg once per day or 100 mg twice per day.

If your AS symptoms don’t ease after 6 weeks of treatment, your doctor may increase your dosage to 400 mg once per day.

If your symptoms don’t ease after another 6 weeks, your doctor may recommend a different treatment option.

Dosage for period pain and menstrual cramps

For dysmenorrhea (period pain and menstrual cramps), the first dose of Celebrex is typically 400 mg. Your doctor may recommend taking an additional 200 mg on your first day of treatment if you need it. After the first day, the usual dosage is 200 mg twice per day, if needed.

Children’s dosage

Celebrex is approved to treat juvenile rheumatoid arthritis (JRA) in children ages 2 years and older. This dosage is described below.

Dosage for juvenile rheumatoid arthritis

The recommended dosage of Celebrex for JRA depends on your child’s body weight. The doses are based on kilograms (kg). 1 kg equals about 2.2 pounds (lb).

For children weighing 10 kg to 25 kg (about 22 lb to 55 lb), the usual dosage is 50 mg twice per day.

For children weighing more than 25 kg (about 55 lb), the usual dosage is 100 mg twice per day.

Long-term treatment

Celebrex may be used as a long-term treatment. For example, if you take Celebrex for conditions such as osteoarthritis or rheumatoid arthritis, you’ll likely take the drug long term. If you take the drug for acute pain or period pain and menstrual cramps, you’ll likely take the drug short term.

It’s important to note that you may have an increased risk of side effects, including serious side effects, if you take Celebrex long term. Due to this risk, your doctor may prescribe the lowest dose possible for the shortest period of time. To learn about Celebrex’s side effects, see this article.

Below are some frequently asked questions about Celebrex.

Does Celebrex have a maximum dose?

Celebrex’s maximum dose per day depends on the condition being treated. In general, the highest dose of Celebrex that doctors prescribe is 400 mg. This can be taken as 400 mg once daily or 200 mg twice daily.

However, you should not increase your Celebrex dosage on your own. If your current dosage isn’t helping ease your symptoms, talk with your doctor. They can advise you on the maximum dosage of Celebrex that’s right for you.

What’s the 200-mg dose of Celebrex prescribed for?

Doctors may prescribe a 200-mg dose of Celebrex for the following conditions:

• acute pain (short-term pain)
• osteoarthritis
• rheumatoid arthritis
• ankylosing spondylitis
• dysmenorrhea (period pain and menstrual cramps)

For details, see “Celebrex dosage” above. If you have questions about the right dosage of Celebrex for you, talk with your doctor.

Is there a recommended dosage for older adults taking Celebrex?

There isn’t a specific dosage of Celebrex for older people (ages 65 years and older). However, older adults have a higher risk for certain side effects than younger adults. So, older adults are usually prescribed a low starting dosage of Celebrex to minimize the risk of side effects. (To learn about Celebrex’s side effects, see this article.)

If you’re an older adult weighing less than 50 kg (about 110 lb), your doctor will likely prescribe the lowest dose of Celebrex possible. This is to help prevent side effects from the medication.

Your doctor can advise you on the dosage of Celebrex that’s right for you.

What’s the Celebrex dosage for fibromyalgia?

At this time, Celebrex is not approved to treat fibromyalgia. However, it’s possible that your doctor may prescribe the drug off-label. This refers to when a doctor prescribes a medication for a different purpose than what it was approved for.

Fibromyalgia is a long-term disorder that causes pain throughout your body. It may also cause sleep problems or fatigue.

One study looked at the use of an antiviral medication called famciclovir and celecoxib in treating fibromyalgia. (Celecoxib is the active drug in Celebrex.) The results showed that this combination of medications may be effective at easing fibromyalgia symptoms.

If you’re interested in taking Celebrex for fibromyalgia, talk with your doctor.

Is there a ‘normal dose’ of Celebrex?

No. The dosage of Celebrex depends on many factors, such as the condition the drug is treating. For other factors, see “Factors that can affect your dosage” below.

Your doctor will help determine the right dosage of Celebrex for you. To learn about the typical dosages of Celebrex to treat certain conditions, see “Celebrex dosage” above.

The Celebrex dosage your doctor prescribes will depend on several factors. These include:

• the type and severity of the condition you’re taking Celebrex for
• your age and body weight
• other medications you take

Other medical conditions you have can also affect your Celebrex dosage.

Dosage adjustments

Your doctor may recommend a lower dose of Celebrex in certain situations. These include:

• having liver problems
• taking other medications that may interact with Celebrex*
• being an older adult (age 65 years or older)
• being an older adult and weighing less than 50 kg (about 110 lb)

To learn more about dosage adjustments for Celebrex, talk with your doctor.

* For additional information about Celebrex interactions, see this article.

It’s important to take Celebrex as your doctor prescribes.

Celebrex comes as an oral capsule that you should swallow whole. You can take it with or without food.

If you have difficulty swallowing the drug, you can open the capsule and sprinkle the contents onto a teaspoon of applesauce. Be sure to empty the entire capsule. And use applesauce that’s cool or room temperature.

It’s important to swallow the medication and applesauce combination right away, along with water. If you need to mix the applesauce and Celebrex ahead of time, you can keep the mixture refrigerated for up to 6 hours. Be sure to take your dose within 6 hours, or it should be discarded.

If you take Celebrex once per day, try to take it at the same time each day. This helps keep a consistent amount of medication in your body so Celebrex can work effectively.

If you take Celebrex twice per day, take the drug in the morning and evening. Try to separate your doses of Celebrex by 12 hours.

ACCESSIBLE DRUG LABELS AND CONTAINERS

If you’re having trouble reading your prescription label, talk with your doctor or pharmacist. Some pharmacies offer labels with large print, braille, or a code you scan with a smartphone to convert text to speech. If your local pharmacy doesn’t have these options, your doctor or pharmacist might be able to recommend a pharmacy that does.

If you’re having trouble opening medication bottles, ask your pharmacist about putting Celebrex in an easy-open container. They also may recommend tools that can make it easier to open bottles.

If you miss a dose of Celebrex, talk with your doctor or pharmacist about the best time to take your next dose. In some cases, they may recommend taking the dose as soon as you remember. In other situations, such as if it’s almost time for your next dose, they may recommend skipping the missed dose. In this case, you would take your next dose at the regular time.

To help make sure that you don’t miss a dose, try using a medication reminder. This can include setting an alarm or using a timer. You could also download a reminder app on your phone.

If you take more Celebrex than your doctor prescribes, you may develop serious side effects.

It’s important that you do not take more Celebrex than your doctor advises.

Symptoms of an overdose

Overdose symptoms of nonsteroidal anti-inflammatory drugs (NSAIDs), such as Celebrex, may include:

• drowsiness
• nausea or vomiting
• abdominal pain
• high blood pressure
• difficulty breathing
• kidney problems, such as kidney failure
• coma

If you take more than the recommended amount of Celebrex

Call your doctor right away if you believe you’ve taken too much Celebrex. Another option is to call the American Association of Poison Control Centers at 800-222-1222 or use its online tool. If you have severe symptoms, immediately call 911 or your local emergency number, or go to the nearest emergency room.

The dosages in this article are typical dosages provided by the drug’s manufacturer. If your doctor recommends Celebrex for you, they will prescribe the dosage that’s right for you. Always follow the dosage that your doctor prescribes for you.

As with any drug, never change your dosage of Celebrex without your doctor’s recommendation. If you have questions about the dosage of Celebrex that’s best for you, talk with your doctor.

Besides learning about dosage, you may want other information about Celebrex. These additional articles might be helpful:

• More about Celebrex. For information about other aspects of Celebrex, refer to this article.
• Drug comparison. Learn how Celebrex compares with ibuprofen and Mobic.
• Details about your condition. For details about reducing inflammation and pain for your condition, see our:
  • arthritis hub
  • rheumatoid arthritis hub
  • list of articles about ankylosing spondylitis

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

instructions for use, price, analogues, composition, indications

Like all medicines, CELECOXIB can cause side effects, although not everyone gets them.

The following are adverse events that have been observed with celecoxib in patients with arthritis.

The adverse reactions listed below, marked with an asterisk (*), have been observed at higher rates in patients receiving high doses and long-term use of celecoxib to prevent colonic polyps.

If you experience any of the following reactions, seek immediate medical attention:

– an allergic reaction such as a skin rash, swelling of the face, shortness of breath or difficulty breathing;

– heart problems such as chest pain;

– severe abdominal pain or any signs of bleeding in the stomach or intestines, such as black stools or vomiting blood;

– a skin reaction such as a rash, blisters or peeling of the skin;

– liver failure (symptoms may include nausea and feeling unwell), diarrhea, jaundice (the skin or whites of the eyes look yellow)).

Very common (may affect up to 1 in 10 people):

• High blood pressure (arterial hypertension), including worsening of hypertension*.

Common (may affect up to 1 in 100 people):

• Myocardial infarction*,

• fluid retention in the body (symptoms of which are swollen ankles, legs and/or hands),

• urinary tract infections,

• infections of the upper respiratory tract,

• shortness of breath*, sinusitis (inflammation of the sinuses), stuffy or runny nose, cough, flu-like symptoms,

• Headache, dizziness, insomnia,

• nausea, vomiting*, abdominal pain, diarrhoea, indigestion, flatulence,

• rash, itching,

• painful joints,

• Accidental injuries,

• Increased sensitivity.

Uncommon (may affect up to 1 in 1000 people):

• stroke*,

• heart failure, palpitations (palpitations), palpitations,

• Increased activity of liver enzymes,

• Increased creatinine levels, increased blood urea levels,

• anemia,

• Anxiety, depression, fatigue, drowsiness, tingling sensation,

• high potassium levels in blood test results (may cause nausea, fatigue, muscle weakness, or palpitations),

• impaired or blurred vision, conjunctivitis (eye inflammation),

• tinnitus, hearing problems*,

• constipation, gastritis, stomatitis, belching, inflammatory diseases of the gastrointestinal tract (indigestion, abdominal pain or vomiting), including worsening of the inflammatory disease of the gastrointestinal tract,

• Leg cramps,

• severe itchy rash (urticaria),

• labored breathing,

• bleeding into the skin (bruising),

• chest pain (general pain not related to the heart),

• Swelling of the face.

Rare (may affect up to 1 in 10,000 people):

• ulcers (bleeding) in the stomach, esophagus, or intestines; bowel perforation (may cause abdominal pain, fever, nausea, vomiting, bowel blockage), dark or black stools, inflammation of the pancreas (may lead to stomach pain), inflammation of the esophagus,

• low levels of sodium in the blood (a condition known as hyponatremia),

• a decrease in the number of white blood cells (which help protect the body from infection) or platelets (increased chance of bleeding or bruising),

• Difficulty in coordinating muscle movements,

• feeling of confusion, taste disturbances,

• Increased sensitivity to light,

• hair loss,

• hallucinations,

• Hemorrhage in the eye,

• pneumonia,

• irregular heartbeat,

• flushes of blood to the face and upper half of the body,

• Sudden blockage of blood vessels in the lungs by a blood clot. Symptoms may include sudden shortness of breath, severe pain when breathing, or acute circulatory failure,

• inflammation of the liver (hepatitis). Symptoms may include nausea (feeling sick), diarrhea, jaundice, dark urine, pale stools, light bleeding, itching or chills,

• acute renal failure,

• violation of the menstrual cycle,

• An allergic reaction with swelling of the face, lips, mouth, tongue, or throat and difficulty swallowing.

Very rare (may affect up to 1 in 10,000 people):

• inflammation of the walls of blood vessels,

• Serious skin diseases such as Stevens-Johnson syndrome (acute toxic-allergic disease with rashes on the skin and mucous membranes), exfoliative dermatitis and toxic epidermal necrolysis (rash, blisters or peeling of the skin) and acute generalized exanthematous pustulosis (redness of the skin with swollen areas covered with numerous small pustules),

• delayed allergic reaction with possible symptoms such as rash, swelling of the face, fever, swollen glands and abnormal test results,

• Liver failure, liver damage, and severe inflammation of the liver (fulminant hepatitis, sometimes fatal or requiring a liver transplant). Symptoms may include nausea (feeling unwell), diarrhea, jaundice, dark urine, pale stools, light bleeding, itching or chills,

• abnormal liver function (such as cholestasis and cholestatic hepatitis, which may be accompanied by symptoms such as discolored stools, nausea, and yellowing of the skin or eyes),

• inflammation of the kidneys and other kidney problems (such as nephrotic syndrome and minimal glomerulonephritis, which may be accompanied by symptoms such as fluid retention (edema), foamy urine, fatigue, and loss of appetite),

• Muscle pain and weakness.

Frequency unknown (cannot be estimated from available data):

• serious allergic reactions, including potentially fatal anaphylactic shock,

• a sharp decrease in the number of all cells of the blood system,

• Intracranial hemorrhage, including fatal,

• meningitis (inflammation of the lining of the brain and spinal cord),

• epilepsy or worsening of epilepsy (possible more frequent and/or severe attacks),

• loss of taste sensations,

• loss of smell,

• blockage of an artery or vein in the eye, leading to partial or complete loss of vision,

• Decreased fertility in women, which is usually reversible upon discontinuation of the drug.

In polyp prevention studies, the following previously unknown adverse reactions occurred in patients treated with celecoxib 400 mg daily for up to 3 years.

Common (may affect up to 1 in 100 people):

• angina pectoris (a form of coronary heart disease, manifested by bouts of chest pain),

• irritable bowel syndrome (symptoms include chronic pain, discomfort, bloating and bowel problems),

• nephrolithiasis,

• increase in the level of creatinine in the blood,

• benign prostatic hyperplasia,

• Increase in body weight.

Uncommon (may affect up to 1 in 1000 people):

• infections caused by Helicobacter, herpes zoster, erysipelas (an infectious disease whose symptoms include reddening of the skin area with general intoxication and fever),

• Bronchopneumonia,

• inflammation of the inner ear, voice disorder, gum infection,

• lipoma (benign neoplasm in adipose tissue),

• Vitreous floaters, conjunctival hemorrhages (inflammation of the mucous membrane of the eye with numerous small hemorrhages),

• Deep vein thrombosis,

• hemorrhoidal bleeding, frequent bowel movements, mouth ulcers,

• allergic dermatitis,

• damage to the sympathetic ganglion (damage to the nervous system with impaired function of internal organs, decreased pain sensitivity, sensitivity disorder, decreased tendon reflexes, emotional disorders),

• increased urination at night,

• vaginal bleeding, breast tenderness,

• Fracture of the lower limb,

• An increase in the level of sodium in the blood.

Reporting adverse reactions

If you experience any adverse reactions, please consult your doctor. This recommendation applies to any possible adverse reactions, including those not listed in the package insert.

You can also report adverse reactions to the information database on adverse reactions (actions) to medicinal products, including reports of drug inefficiency detected in the state (UE Center for Expertise and Testing in Healthcare, rceth.by). By reporting adverse reactions, you help to get more information about the safety of the drug.

What helps, active substance, composition, radar

THERE ARE CONTRAINDICATIONS. POSSIBLE SIDE EFFECTS. A SPECIALIST’S CONSULTATION IS REQUIRED.ArthritisArthrosisPainkillers

The author of the article

Zotina Natalya Igorevna,

Diploma of pharmaceutical education: 105924 1197876, reg. number 30353

All authors

Contents of the article

• Celebrex: active substance
• Celebrex: pills for what
• Celebrex: course of treatment for how many days
• Celebrex: contraindications
• Celebrex: side effects
• Celecoxib or Celebrex: which is better
• Movalis or Celebrex: which is better
• Celebrex or Arcoxia
• Summary
• Ask an expert about the topic of the article

Time moves inexorably into the distance: people grow up, and with age come joint problems. The most common disease, the symptoms of which appear in the fourth and fifth decades of life, and by the age of 80 almost everyone has it, is osteoarthritis. The disease is manifested by stiffness of movements after a period of rest, an increase in the volume of the affected joint, and most importantly, pain. The last symptom forces a person to take painkillers.

The pharmacist will tell you about Celebrex: introduce you to its active ingredient, indications for use, contraindications and side effects, and compare it with analogues.

Celebrex: active ingredient

Celebrex is an anti-inflammatory drug in the form of capsules. Patients are often interested in Celebrex tablets or Celebrex injections, but the drug is not available in such forms.

Celebrex belongs to the German company Pfizer. The active substance of the drug is Celecoxib, which has anti-inflammatory, analgesic and antipyretic effects.

All products Celebrex

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Celebrex: pills for what

According to the register of medicines (RLS) – Celebrex is indicated for the relief of symptoms of pain and inflammation in:

• Diseases of the musculoskeletal system: osteoarthritis, rheumatoid arthritis and ankylosing spondylitis;
• Pain syndrome: postoperative, musculoskeletal, as well as for relief of back pain;
• Primary dysmenorrhea – pain in the lower abdomen during menstruation in adolescent girls.

Celebrex: course of treatment for how many days

It is recommended to take Celebrex in the shortest possible courses, on average, from 7 to 10 days. Treatment should be prescribed and adjusted by a doctor, as there is a risk of developing serious adverse reactions.

Celebrex: before or after meals

Eating does not reduce the effectiveness of the drug, so the capsules can be taken regardless of food. As a rule, therapy begins with a dosage of 100 mg with a further increase if necessary until Celebrex 200 mg. The maximum possible dosage is 400 mg, but its use is indicated only when absolutely necessary.

Celebrex: contraindications

• Hypersensitivity to drug components
• Hypersensitivity to sulfonamide antimicrobials
• Combination of bronchial asthma, nasal polyposis and intolerance to acetylsalicylic acid (Aspirin)
• Recovery period after coronary bypass surgery
• Active gastric and duodenal ulcers
• Exacerbation of inflammatory bowel disease
• Chronic heart failure
• Ischemic heart disease and peripheral vascular disease
• Stroke and hemorrhage
• Renal and liver failure
• Lactase deficiency, lactose intolerance and glucose-galactose malabsorption
• Pregnancy and breastfeeding period
• Under 18 years of age

Celebrex and alcohol: compatible

During therapy, it is recommended to refrain from taking alcoholic beverages, since the combined effect of alcohol and Celebrex capsules will greatly increase the negative impact on the cardiovascular and digestive systems.

Celebrex: side effects

• Edema of the lower extremities
• Increased blood pressure
• Abdominal pain
• Nausea, vomiting and diarrhea
• Dizziness
• Insomnia
• Urinary tract infections
• Cough and bronchitis
• Skin rash and itching
• Tinnitus
• Increased activity of liver enzymes
• Flu-like syndrome
• Anaphylactic reactions

Celecoxib or Celebrex: which is better

Celecoxib is not only the active substance of Celebrex, but also an independent drug. It is also available in capsule form by several pharmaceutical companies.

Celecoxib and Celebrex are direct analogues that are as similar as possible in terms of therapeutic effects and other indicators. Therefore, in the presence of a prescription, the patient may decide to purchase the drug based on personal preferences, doctor’s recommendations or affordability.

Patients often ask which is better: Celebrex or Dilaxa. However, Dilaxa is one of the trade names for Celecoxib, which means the situation will be similar.

All products Celecoxib

5 reviews

Movalis or Celebrex: which is better

Movalis is a German anti-inflammatory drug with Meloxicam as an active ingredient. Produced in the form of tablets and solution for intramuscular injection. Compare drugs:

• A significant plus of Movalis is the presence of a solution for injection, since this allows less impact on the gastric mucosa and relieves more pronounced pain;
• Celebrex is safer for the stomach, and Movalis for the heart;
• Duration of action of Movalis is from 13 to 25 hours, Celebrex is from 8 to 11 hours, while the analgesic effect of Celebrex comes earlier;
• Movalis is used to treat children from 12 years of age, as well as younger children with juvenile rheumatoid arthritis;
• Movalis is not used for dysmenorrhea.

It is impossible to say unequivocally which is better: Celebrex or Meloxicam. Drugs have individual characteristics that are recommended to be taken into account when prescribing the drug.

All products Movalis

20 reviews

Celebrex or Arcoxia

Arcoxia is an anti-inflammatory drug with Etoricoxib. Produced in Spain, but owned by a Dutch pharmaceutical company. Unlike Celebrex, Arcoxia:

• Available in tablet form;
• Begins to work one hour after ingestion, while the effect of Celebrex occurs after 2-3 hours;
• Lasts 22 hours while Celebrex lasts 8 to 11 hours;
• Used to treat children from 16 years of age;

Celebrex or Arcoxia: which is better. Arcoxia has faster and longer-lasting effects, which makes it stand out. However, the final decision on taking the drug remains with the doctor.

Nise or Celebrex: which is better

Nise is an anti-inflammatory drug produced in Russia and India. The active substance of the drug is Nimesulide. Unlike Celebrex, it is available not only in the form for oral administration, but also in the form of a gel for external use. Preparations differ according to the following criteria:

• The field of application of Nise is wider. For example, it includes osteochondrosis, pain in muscles and ligaments;
• Nise begins to act after 1.5-2.5 hours;
• Nise has a significant number of contraindications and has a greater effect on the gastric mucosa.

Thus, Celebrex is safer to use, but in some situations, Nimesulide is indispensable.

All goods Nise

21 review

All goods Arcoxia

21 reviews

Summary

• Celebrex is an anti-inflammatory drug in the form of capsules.
• Celebrex is indicated for the relief of symptoms of pain and inflammation.
• Celebrex is recommended to be taken in the shortest possible courses averaging 7 to 10 days.