Clotrimazole / Clobetasol Propionate – Product

Clotrimazole / Clobetasol Propionate – Product – TabletWise

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TabletWise

• Overview
• Uses
• Side-effects
• Precautions
• Interactions
• Contraindications

Overview

Clotrimazole / Clobetasol Propionate is used for Treatment of athlete’s foot, Treatment of jock itch, Treatment of ringworm, Relief of itching, Burning, Cracking, And scaling associated with athlete’s foot, Jock itch and ringworm, Prevention of oral thrush, Inflammatory skin conditions, Itching and other conditions.

This salt combination may also be used for purposes not listed in this medication guide.

Detailed information related to Clotrimazole / Clobetasol Propionate’s uses, side-effects, reviews, questions, interactions, and precautions is as follows:

Uses

Clotrimazole / Clobetasol Propionate is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:

• Treatment of athlete’s foot
• Treatment of jock itch
• Treatment of ringworm
• Relief of itching, burning, cracking, and scaling associated with athlete’s foot, jock itch and ringworm
• Prevention of oral thrush
• Inflammatory skin conditions
• Itching
• Clotrimazole / Clobetasol Propionate may also be used for purposes not listed here.

Learn more: Uses

Side-effects

The following is a list of possible side-effects that may occur in medicines that contain Clotrimazole / Clobetasol Propionate. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.

• Itching
• Burning
• Irritation
• Redness
• Swelling
• Stomach pain
• Fever
• Foul-smelling discharge if using the vaginal product
• Upset stomach
• Vomiting if using the lozenges
• Stinging i dryness at the application site
• Clotrimazole / Clobetasol Propionate may also cause side-effects not listed here.

If you notice other side-effects not listed above, contact your doctor for medical advice. You may also report side-effects to your local food and drug administration authority.

Precautions

Before using Clotrimazole / Clobetasol Propionate, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side-effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.

• Acquired immunodeficiency syndrome
• Alcohol use
• Allergic reaction to this drug
• Avoid contact with eyes
• Avoid contact with the eyes for cream
• Diabetes
• Do not use in children under 2 years of age unless directed by a doctor
• Do not use on diaper rash
• Do not use this medicine for diaper rash
• History of alcohol abuse

Interactions with Clotrimazole / Clobetasol Propionate

If you use other drugs or over the counter products at the same time, the effects of Clotrimazole / Clobetasol Propionate may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Clotrimazole / Clobetasol Propionate may interact with the following drugs and products:

• Cyclosporine
• Latex contraceptives
• Prednisone

When not to use Clotrimazole / Clobetasol Propionate

Frequently asked Questions

• Is Clotrimazole / Clobetasol Propionate safe to use when pregnant?

  • Clotrimazole: Please consult with your doctor for case-specific recommendations.
  • Clobetasol Propionate: Please consult with your doctor for case-specific recommendations.

• Is Clotrimazole / Clobetasol Propionate safe while breastfeeding?

  • Clotrimazole: Please discuss the risks and benefits with your doctor.
  • Clobetasol Propionate: Please discuss the risks and benefits with your doctor.

• Is it safe to drive or operate heavy machinery when using this product?

  If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Clotrimazole / Clobetasol Propionate medicine then it may not be safe to drive a vehicle or operate heavy machinery. One should not drive a vehicle if using the medicine makes you drowsy, dizzy or lowers your blood-pressure extensively. Pharmacists also advise patients not to drink alcohol with medicines as alcohol intensifies drowsiness side-effects. Please check for these effects on your body when using Clotrimazole / Clobetasol Propionate. Always consult with your doctor for recommendations specific to your body and health conditions.

• Is this medicine or product addictive or habit forming?

  Most medicines don’t come with a potential for addiction or abuse. Usually, the government’s categorizes medicines that can be addictive as controlled substances. Examples include schedule H or X in India and schedule II-V in the US. Please consult the product package to make sure that the medicine does not belong to such special categorizations of medicines. Lastly, do not self-medicate and increase your body’s dependence to medicines without the advice of a doctor.

• Can i stop using this product immediately or do I have to slowly wean off the use?

  Some medicines need to be tapered or cannot be stopped immediately because of rebound effects. Please consult with your doctor for recommendations specific to your body, health and other medications that you may be using.

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APA Style Citation

• Clotrimazole / Clobetasol Propionate – Product – tabletwise.net. (n.d.). Retrieved April 24, 2023, from https://www. tabletwise.net/medicine/clotrimazole-clobetasol-propionate

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Chicago Style Citation

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More about Clotrimazole / Clobetasol Propionate

• Uses
• Reviews

• What are the uses of Clotrimazole / Clobetasol Propionate?
• What are the side-effects of Clotrimazole / Clobetasol Propionate?
• What other medicines does Clotrimazole / Clobetasol Propionate interact with?
• When should you not use Clotrimazole / Clobetasol Propionate?
• What precautions should you take while using Clotrimazole / Clobetasol Propionate?

Last updated date

This page was last updated on 9/28/2020.

This page provides information for Clotrimazole / Clobetasol Propionate Product in English.

• Athlete’s Foot

  Athlete’s foot is a common infection caused by a fungus. It …

• Jock Itch

  A skin infection caused by a fungus.

• Tinea Infections

  Tinea is the name of a group of diseases caused by a fungus. …

• Athlete’s Foot

  Athlete’s foot is a common infection caused by a fungus. It …

Learn More

Athlete’s Foot

Athlete’s foot is a common infection caused by a fungus. It …

Jock Itch

A skin infection caused by a fungus.

Tinea Infections

Tinea is the name of a group of diseases caused by a fungus. …

Athlete’s Foot

Athlete’s foot is a common infection caused by a fungus. It …

Athlete’s Foot

Jock Itch

Tinea Infections

Athlete’s Foot

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clobetasol topical: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

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Arpimed

Clobetasol, 0.05% ointment

Form of releaseSoft

ATC category Glucocorticoid drugs (GCS)

ATC subcategory GCS for external use

Trade name Clobetasol

International drug name Clobetasol

What Clobetasol is and what it is used for

Clobetasol Propionate is the active ingredient in Clobetasol.

Clobetasol belongs to a group of medicines called steroids.

Clobetasol helps reduce swelling and skin irritation.

Clobetasol is prescribed to relieve redness and itching in certain skin conditions. These lesions include:

• often recurrent eczema
• psoriasis (thickened areas of inflamed, reddened skin, often covered with silvery scales), excluding extensive plaque psoriasis.
• lichen planus (a skin disease that causes itching, red-purple rashes on the wrists, forearms, or lower limbs)
• discoid lupus erythematosus (skin disease most commonly affecting the face, ears and scalp, causing scarring and increased sensitivity of the affected skin to sunlight)
• dermatitis and other skin disorders not responsive to weaker steroid creams or ointments.

What you need to know before you use Clobetasol

Do not take Clobetasol if

• You are allergic (hypersensitive) to clobetasol propionate or any of the other ingredients of this medicine
• Children under 1 year old
• For the treatment of the following dermatological conditions as they may worsen:
• acne
• rosacea
• mottled red rash around the mouth (perioral dermatitis)
• anal and genital itching
• skin infection if the disease is not treated simultaneously with antibacterial drugs
• itching of the skin, not accompanied by inflammation
• extensive plaque psoriasis, except in cases with single lesions.

Do not use Clobetasol if you have any of these conditions. If in doubt, ask your doctor or pharmacist for advice.

Warnings and Precautions

Talk to your doctor or pharmacist before using Clobetasol:

• If you have had an allergic reaction to other steroids in the past.
• If you plan to apply the drug under an airtight bandage or on a baby’s diaper, as they enhance the absorption of the active substance through the skin. This may lead to a risk of overabsorption of the drug.
• Make sure the skin is clean before applying a new dressing to prevent infection.
• When applying the ointment to broken skin or skin folds.
• When applied to large areas of skin
• If you have psoriasis, you should consult your doctor more often.
• In the treatment of chronic leg ulcers as there may be an increased risk of an allergic reaction or infection.
• When applied near the eyes or on the eyelids, as this may cause the development of cataracts or glaucoma if the ointment is constantly in contact with the eyes.
• When applied to thin areas of the skin, such as the face, as Clobetasol may cause thinning of the facial skin. The duration of application on the face should not exceed 5 days. When applying the ointment to the skin of the face, the use of occlusive dressings or bandages is not recommended.

If you develop an infection while using this drug, talk to your doctor or pharmacist.

If in any doubt about your condition, ask your doctor or pharmacist before using Clobetasol.

Children

• Do not use this medicine in children under 1 year of age.
• Avoid prolonged long-term treatment in children over 1 year of age, as their skin is thinner than that of adults, which may enhance absorption of the active substance.
• Use in children should not exceed 5 days.
• The use of occlusive dressings and bandages is not recommended in places where the ointment is applied.

Other medicines and Clobetasol

Tell your doctor or pharmacist if you are taking, have recently taken or should take any other medicines, especially ritonavir and itraconazole.

Pregnancy and breast-feeding

If you are pregnant or breast-feeding, think you may be pregnant or planning to become pregnant, ask your doctor or pharmacist before taking this medicine.

If you use the drug while breastfeeding, do not apply the ointment to the chest area, so that Clobetasol does not accidentally get into the baby’s mouth.

Important information about the ingredients that make up Clobetasol 25 propylparaben, which can cause allergic reactions (possibly delayed) and very rarely, bronchospasm.

How to take Clobetasol

Clobetasol should be taken exactly as directed by your doctor. If you have any doubts, you should consult your doctor or pharmacist.

How to use Clobetasol

• Usually Clobetasol is applied in a thin layer 1-2 times a day. The frequency of application may decrease as the condition of the skin improves. Your doctor may prescribe a weaker drug instead of Clobetasol if necessary.
• If you plan to use an emollient, apply Clobetasol first, allow it to absorb, and then apply the emollient.
• This ointment is for skin use only.
• Do not use Clobetasol for more than 4 weeks without consulting a physician. If you need long-term treatment, your doctor may prescribe a weaker steroid cream or ointment.
• If the skin condition does not improve within 2-4 weeks, contact your doctor.
• Pathogenic microorganisms may contribute to the development of infection in warm and humid conditions under occlusive dressings. Always rinse your skin before applying a new dressing to prevent skin infections.
• If you are applying the ointment to someone else, wash your hands thoroughly before use or wear disposable gloves.

How to use Clobetasol ointment

1. Wash your hands.
2. Apply a thin layer of ointment to the affected areas, rub lightly into the skin for complete absorption. You can dose Clobetasol by applying it to your fingertip. For dosing in children, use less ointment, but still use an adult’s finger as the dosing unit.

This picture shows the dosage unit – 1 Fingertip Unit (FTU).

FingerTip Unit – the amount of ointment from a tube with a hole diameter of 5 mm, covering the distal phalanx of the index finger of an adult.

3. Rinse hands thoroughly after applying the ointment, unless the skin of the hands is affected and is the area for application of the ointment.

Adult doses

Adult

Face & Neck: 2.5 FTU

Back torso: 7 FTU

Front torso: 7 FTU

One hand (not including hand): 3 FTU

Both sides of one hand: 1 FTU

One leg (not including feet): 6 FTU

One foot : 2 FTU

Don’t worry if you’ve used a little more or less ointment than you should, and only uneven distribution is observed.

Doses for children from 1 to 10 years old 280

Required quantity e units FTU

Childhood

Face and neck

Arm and hand

Leg and foot

Front torso

Back including buttocks

1-2 years

1.5

1.5

2

2

3

3-5 years

1.5

2

3

3

3. 5

6-10 years

2

2.5

4.5

3.5

5

• Do not use in children under 1 year of age.
• In children, it is especially important not to exceed the prescribed dose.
• The course of treatment should not exceed 5 days – unless your doctor has prescribed a longer course of treatment. The doctor may schedule a consultation for your child every week.
• The use of occlusive dressings or bandages in children is not recommended where the ointment is applied.

If you have psoriasis mating. However, this is recommended when applying the ointment at night to enhance the effect. After a short period of time, you need to return to the usual mode of applying the ointment.

If you are using Clobetasol on facial skin

You may only apply the ointment to your face if advised by your doctor. It is not recommended to use the ointment for more than 5 days, as long-term use of the drug leads to thinning of the skin. Dressings and bandages are not recommended for use on the face where ointment is applied. Avoid getting Clobetasol in the eyes. If this happens, flush your eyes with plenty of water.

If you have taken more Clobetasol than you have been prescribed

If you have used too much ointment or accidentally swallowed it, contact your doctor or the nearest hospital emergency department immediately.

If you forget to take Clobetasol

If you forget to take your next dose, take it as soon as you remember. If the time has come for the next use of Clobetasol, wait until this moment, and then use the drug. Do not take an extra dose to make up for a missed one.

If you stop using Clobetasol

If you use Clobetasol regularly and want to stop using it, you should talk to your doctor before you stop using this drug, as your condition may worsen abruptly if you stop using it the use of the drug.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

Possible side effects

Like all medicines, Clobetasol can cause side effects, although not everyone gets them.

Stop using Clobetasol and tell your doctor immediately if:

• you find that your skin condition is getting worse, you develop a generalized rash, or your skin is swollen during treatment. You may be allergic to Clobetasol, have an infection, or need other treatment
• You have psoriasis and there are raised bumps with pus under the skin. This can occur very rarely during or after treatment and is known as pustular psoriasis.

Other side effects , in places of application of the ointment.

Rare (may affect up to 1 in 100)

• Thinning of the skin, which can cause stretch marks
• Under the surface of the skin, blood vessels may become more visible

Very rare (may affect up to 1 in 10,000 people)

Long-term use of the drug or use under an occlusive dressing may cause the following symptoms:

• weight gain
• face rounding
• obesity
• facial thinning
• skin wrinkling
• dry skin
• changes in the color of your skin
• body hair extension
• hair loss, lack of growth, hair damage

Other very rare skin reactions:

• allergic reactions at the site of application
• deterioration
• irritation and pain at the site of application
• redness
• rash or urticaria
• if you have psoriasis, you may have raised bumps with pus under your skin. This may appear during or after treatment and is known as pustular psoriasis.
• skin infections
• acne

In children, pay attention to the following symptoms:

• slow weight gain
• slow growth

Very rare side effects that may show up on blood tests or a doctor’s examination.

• low level of the hormone cortisol in the blood
• elevated blood sugar or urine
• high blood pressure
• increased intraocular pressure (glaucoma)
• weakening of bones due to gradual loss of minerals (osteoporosis). After a routine medical examination, additional tests may be required to confirm this condition.

Reporting side effects

If you notice any side effects, tell your doctor, pharmacist or pharmacist, including any side effects not listed in this package insert. You can also report side effects to Arpimed LLC by going to site www . arpimed . com and fill out the appropriate form “Report a side effect or ineffectiveness of a drug” and to the Scientific Center for Expertise of Drugs and Medical Technologies named after. Academician E. Gabrielyan by going to the website www . pharm . am to the “Report a Medication Side Effect” section and fill out the “Medication Side Effect Reporting Card”. Scientific center hotline: +37410237665; +37498773368 By reporting side effects, you help provide more information about the safety of this drug.

How to store Clobetasol

• Keep out of the reach of children, cool, protected from moisture and light.
• Shelf life – 3 years. Do not take Clobetasol after the expiry date which is stated on the package. When specifying the expiration date, the last day of the specified month is meant. Shelf life after opening is 6 months.
• Medicines should not be disposed of into wastewater or sewers. Ask your pharmacist how to dispose of a medicine you no longer need. These measures are aimed at protecting the environment.

Contents of the pack and other information

What Clobetasol contains

Each gram of Clobetasol 0.05% ointment contains: : clobetasol propionate- 0.5mg

What Clobetasol looks like and contents of the pack:

White, odorless ointment.

Description of packaging

0.05% topical ointment 15g in aluminum tubes with leaflet in a cardboard box.

Dispensing conditions

Prescription

Clobetasol – description of the substance, pharmacology, use, contraindications, formula

Contents

• Structural formula

• Russian name

• English name

• Latin name

• chemical name

• Gross formula

• Pharmacological group of the substance Clobetasol

• Nosological classification

• CAS code

• pharmachologic effect

• Characteristic

• Pharmacology

• Application of the substance Clobetasol

• Contraindications

• Use during pregnancy and lactation

• Side effects of the substance Clobetasol

• Overdose

• Dosage and administration

• Precautionary measures

• Trade names with the active substance Clobetasol

Structural formula

Russian name

Clobetasol

English name

Clobetasol

Latin name

Clobetazolum ( genus 90 786 Clobetazoli)

Chemical name

(11beta,16beta)-21-Chloro-9- fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione (and as propionate)

Gross formula

C ₂₂ H ₂₈ ClFO ₄

Pharmaceutical substance group Clobetasol

Glucocorticosteroids

Nosological classification

ICD-10 code list

• L30. 9 Dermatitis, unspecified

• L40 Psoriasis

• L43 Lichen red flat

• L93.0 Discoid lupus erythematosus

• L98. 9 Disorder of skin and subcutaneous tissue, unspecified

CAS code

25122-41-2

Pharmacological action

Pharmacological action –

glucocorticoid , antiallergic , anti-inflammatory , antipruritic .

Characteristics

Glucocorticoid for topical use.

Clobetasol propionate is a white or off-white crystalline powder, insoluble in water. Molecular weight 467.

Pharmacology

Induces the formation of lipocortin proteins that inhibit the activity of phospholipase A ₂ , inhibits the formation of arachidonic acid and its metabolic products – prostaglandins, leukotrienes. Eliminates swelling, hyperemia, itching at the site of application.

When applied topically, absorption into the systemic circulation is possible. Absorption is more pronounced when applied to large areas of the skin. It is metabolized mainly in the liver, a small part – in the kidneys. Excreted with urine.

Application of the substance Clobetasol

Cream, ointment. Psoriasis (except pustular and widespread plaque), chronic eczema, lichen planus, discoid lupus erythematosus; skin diseases resistant to therapy with less active topical GCs.

Shampoo. Treatment and prevention of recurrence of scalp psoriasis in adults (except pustular and widespread plaque).

Contraindications

Hypersensitivity, rosacea, acne vulgaris, skin cancer, perioral dermatitis, bacterial, viral and fungal infections of the skin (including herpes simplex, chicken pox, actinomycosis), skin tuberculosis, genital and perianal pruritus, children under 1 year of age (cream, ointment) or up to 18 years (shampoo).

Use during pregnancy and lactation

During pregnancy, it is possible if the expected benefit to the mother outweighs the potential risk to the fetus.

FDA Fetal Category C.

Breastfeeding should be discontinued during treatment.

Side effects of the substance Clobetasol

Local reactions: burning, pruritus, acne, dry skin, striae; with prolonged use – skin atrophy and telangiectasia, hypertrichosis, pigmentation disorders, weakening of the skin barrier function, development of the pustular form of psoriasis.

When applied to large surfaces of the body, systemic reactions are possible: gastritis, ulceration of the gastrointestinal mucosa, increased intraocular pressure, symptoms of hypercortisolism, allergic reactions.

Overdose

Symptoms of chronic overdose: signs of hypercortisolism.

Treatment: drug withdrawal under medical supervision.

Dosage and administration

Externally. Ointment or cream is applied in a thin layer to the affected areas of the skin 1-2 times a day until improvement occurs. With persistent skin lesions (especially with hyperkeratosis), the effect is enhanced by applying an occlusive dressing at night.

The ointment is recommended for skin lesions accompanied by dryness, hyperkeratosis, thickening, since the ointment base of the drug helps to retain moisture in the skin. The cream is recommended for use in processes accompanied by weeping and severe inflammation.

The shampoo is applied only to the scalp.

Precautions

Clobetasol is recommended for short-term use. If necessary, it is possible to conduct short repeated courses. On the face, more often than on other parts of the body, atrophic changes in the skin may appear as a result of prolonged use of local GCs.

Avoid getting the cream (ointment) in the eyes (intraocular pressure may increase). Before applying a fresh dressing, the skin should be cleaned, because. The heat and moisture created by sealed dressings encourages bacterial infection.

Avoid contact of shampoo with eyes and eyelids (risk of glaucoma, cataracts) or ulcerated skin surfaces.