Colestipol Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

Colestipol is used along with a proper diet to lower cholesterol in the blood. Lowering cholesterol helps decrease the risk for strokes and heart attacks.In addition to a proper diet (such as a low-cholesterol/low-fat diet), other lifestyle changes that may help this medication work better include exercising, losing weight if overweight, and stopping smoking. Consult your doctor for more details.This medication is known as a bile acid-binding resin. It works by removing bile acid from the body. In people with high cholesterol, this causes the liver to make more bile acid by using cholesterol in the blood. This helps to lower the cholesterol levels.

How to use colestipol oral

Take this medication by mouth as directed by your doctor, usually 1 to 2 times a day. If your dose is more than 1 tablet, take the tablets one at a time. Do not try to swallow more than one tablet at once. Take each tablet with plenty of liquid (such as water, juice). Swallow each tablet whole. Do not crush, chew, or break the tablets. If you have difficulty swallowing the tablet whole, consult your doctor.

The dosage is based on your medical condition and response to treatment. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor’s instructions carefully. It may take several weeks before you get the full benefit of this drug.

Colestipol may decrease your absorption of other medications. Take your other medications as directed by your doctor, usually at least 1 hour before or 4 to 6 hours after colestipol. Ask your doctor or pharmacist for more information or if you have any questions.

Take this medication regularly in order to get the most benefit from it. To help you remember, take it at the same time(s) each day. Keep taking this medication even if you feel well. Most people with high cholesterol do not feel sick.

Side Effects

Constipation, stomach/abdominal pain, gas, nausea, and vomiting may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

To prevent constipation, eat dietary fiber, drink enough water, and exercise. You may also need to take a laxative. Ask your pharmacist which type of laxative is right for you.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: difficulty swallowing, chest pain/pressure, severe stomach/abdominal pain, unusual bleeding/bruising, rapid breathing, confusion.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking colestipol, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: swallowing problems, constipation, hemorrhoids, kidney disease.

Because this drug can interfere with the absorption of certain nutrients (such as folic acid, fat-soluble vitamins including A, D, E, K), your doctor may direct you to take a multivitamin supplement. Consult your doctor for more information.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially constipation.

During pregnancy, this medication should be used only when clearly needed. It may affect the absorption of certain nutrients. Discuss the risks and benefits with your doctor.

This medication is unlikely to pass into breast milk. However, it may affect the absorption of certain nutrients. Consult your doctor before breast-feeding.

Interactions

See also How to Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug include: “blood thinners” (such as warfarin), mycophenolate, raloxifene.

Does colestipol oral interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe stomach/abdominal pain.

Do not share this medication with others.

Lab and/or medical tests (such as blood cholesterol/triglyceride levels, vitamin levels) should be done while you are taking this medication. Keep all medical and lab appointments. Consult your doctor for more details.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

colestipol 1 gram tablet

Color: yellowShape: ovalImprint: CZ

This medicine is a yellow, oval, film-coated, tablet imprinted with “CZ”.

colestipol 1 gram tablet

Color: off-whiteShape: ovalImprint: G

This medicine is a yellow, oval, film-coated, tablet imprinted with “CZ”.

colestipol 1 gram tablet

Color: yellowShape: ellipticalImprint: G 450

This medicine is a yellow, oval, film-coated, tablet imprinted with “CZ”.

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Drug Survey

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Colestipol: MedlinePlus Drug Information

pronounced as (koe les’ ti pole)

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Colestipol is used along with diet changes to decrease the amount of fatty substances such as low-density lipoprotein (LDL) cholesterol (‘bad cholesterol’) in certain people with high cholesterol. Colestipol is in a class of medications called bile acid sequestrants. It works by binding bile acids in your intestines to form a product that is removed from the body.

Colestipol comes as tablets and granules to take by mouth. The tablets are usually taken once or twice daily. The granules are usually taken one to six times daily. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take colestipol exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Unless otherwise instructed, take all other medications at least 1 hour before or 4 hours after you take colestipol because it can interfere with their absorption.

Swallow the tablets whole with a glass of water or another liquid; do not chew, split, or crush them.

Your doctor may gradually increase your dose at 1 to 2 month intervals, depending on your response.

Continue to take colestipol even if you feel well. Do not stop taking colestipol without talking to your doctor.

Do not take the granules dry. Add them to at least 3 ounces (90 milliliters) of a liquid (e.g., fruit juice, water, milk, or soft drink) and stir until completely mixed. If you use a carbonated beverage, mix it slowly in a large glass to minimize foaming. After taking the dose, rinse the glass with a small amount of additional liquid and drink it to be sure that you receive the entire dose.

Colestipol also may be mixed with hot or regular breakfast cereals, thin soups (e.g., tomato and chicken noodle), or pulpy fruit (e.g., crushed pineapple, pears, peaches, and fruit cocktail).

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking colestipol,

• tell your doctor and pharmacist if you are allergic to colestipol, any other medications, or any of the ingredients in colestipol preparations. Ask your pharmacist for a list of the ingredients.
• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amiodarone (Pacerone), antibiotics, anticoagulants (‘blood thinners’) such as warfarin (Coumadin, Jantoven), digitoxin, digoxin (Lanoxin), diuretics (‘water pills’), iron, loperamide (Imodium), mycophenolate (Cellcept), oral diabetes medications, phenobarbital, phenylbutazone, propranolol (Inderal, Innopran), and thyroid medications. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
• tell your doctor if you have or have ever had unusual bleeding, an underactive thyroid gland, heart or intestinal disease, or if you have hemorrhoids.
• if you are taking gemfibrozil (Lopid), take it 2 hours before or 2 hours after colestipol.
• tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking colestipol, call your doctor.

Eat a low-fat, low-cholesterol diet. Be sure to follow all exercise and dietary recommendations made by your doctor or dietitian. You can also visit the National Cholesterol Education Program (NCEP) website for additional dietary information at http://www.nhlbi.nih.gov/health/public/heart/chol/chol_tlc.pdf.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed dose.

Colestipol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• constipation
• belching
• nausea
• vomiting
• gas

Some side effects can be serious. If you experience the following symptom, call your doctor immediately:

• unusual bleeding (such as bleeding from the gums or rectum)

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online (http://www. fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.

• Colestid^®
• Colestid^® Flavored Granules
• Colestid^® Granules

Last Revised – 09/15/2018

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Description of COLESTIPOL indications, dosages, contraindications of the active substance COLESTIPOL

instructions for use, dosage, composition, analogues, side effects / Pillintrip

Page reviewed by pharmacist Fedorchenko Olga Valerievna Last update 2022-03-25

Attention!
The information on this page is for healthcare professionals only!
The information is collected from open sources and may contain significant errors!
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Description Colestid is an automatic translation from the original language.
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Colestid

Composition

Description Composition Colestid is an automatic translation from the original language.
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COLESTID Tablets, yellow, elliptical, with imprint U and
supplied as follows:

Bottles of 120 NDC 0009-0450-03
Bottles of 500 NDC 0009-0450-04

Each tablet contains 1 gram of colestipol hydrochloride.

Store at controlled room temperature between 20° and 25°C (68° to
77°F).

Common: Pharmacia

Therapeutic indications

Description Therapeutic indications Colestid is an automatic translation from the original language.
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pay strict attention to indications and contraindications, especially when choosing
drugs for chronic long-term use.

COLESTID tablets are indicated as adjunctive therapy to
diet to reduce elevated levels of total cholesterol and LDL cholesterol in blood serum in patients with
primary hypercholesterolemia (elevated LDL cholesterol), which do not respond adequately to
on a diet. As a rule, COLESTID tablets do not have a clinically significant effect on
serum triglyceride levels, but with their use, triglyceride levels may be elevated in some
patients.

Therapy with lipid-altering drugs should be a component
multiple intervention of risk factors in individuals with significantly
increased risk of atherosclerotic vascular disease due to
hypercholesterolemia. Treatment should begin and continue with diet therapy
(See Hypercholesterolemia Guidelines
A minimum of six months of intensive dietary therapy and counseling should be completed prior to initiation of drug therapy.
Shorter periods may be considered in patients with marked elevation
LDL-C level or certain CAD.

According to NCEP guidelines, the goal of treatment is
is a decrease in LDL-C, and LDL-C should be used to initiate and evaluate
response to treatment. Only if LDL-C is not available should total LDL be used to
therapy monitoring. Recommendations for the treatment of NCEP are given below.

Certain Atherosclerotic Disease*	Two or more Other risk factors**	Excitation level	Target
No	No	≥ 190 ( ≥ 4.9)	< 160 ( < 4.1)
No	Yes	≥ 160 ( ≥ 4.1)	< 130 ( < 34)
Yes	Yes or No	≥ 130 ( ≥ 3.4)	≤ 100 ( ≤ 26)
* Ischemic heart disease or peripheral vascular disease (including symptomatic carotid disease). ** Other risk factors for coronary heart disease (CHD) include: age (men: ≥ 45 years, female: ≥ 55 years or premature menopause without estrogen replacement therapy), family history of premature CAD, current cigarette smoking, hypertension, confirmed HDL-C < 35 mg/dL (0.91 mmol/L) and diabetes. Subtract one risk factor if HDL cholesterol is ≥ 60 mg/dL (1.6 mmol/l).

Dosage and administration

Description Dosage and Administration Colestid is an automatic translation from the original language.
Do not use this information for any medical prescription or manipulation under any circumstances.
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For adults, COLESTID tablets are recommended in doses from
2 to 16 g/day once or in divided doses. The initial dose should be 2
grams once or twice a day. Increase dose by 2 grams once or twice a day
should occur at intervals of 1 or 2 months. Appropriate use of lipid profiles is recommended in
according to NCEP guidelines, including LDL-C and triglycerides to
use optimal, but not excessive doses to obtain the desired therapeutic
effect on the level of LDL-C .. If the desired therapeutic effect is not achieved in
dose from 2 to 16 g/day with good compliance and acceptable side effects,
combination therapy or alternative treatment should be considered

COLESTID tablets should be taken one at a time and
swallow quickly whole with plenty of water or other suitable liquid.
Do not cut, crush, or chew tablets. Patients should take other drugs for at least
at least one hour before or four hours after taking COLESTID tablets to minimize possible
interfere with their absorption. (See DRUG INTERACTIONS .)

Before COLESTID tablets

• Determine the type of hyperlipoproteinemia as described in
  Recommendations for hypercholesterolemia.
• Experiment with diet and weight loss.
• Establish baseline levels of total and LDL-C and triglycerides in serum
  levels.

When using COLESTID tablets

1. The patient must be under close clinical supervision,
   including serum cholesterol and triglyceride levels. Periodic definition
   serum cholesterol levels, as outlined in the hypercholesterolemia guidelines, should be monitored for
   confirmation of a favorable initial and long-term response.
2. Failure of total or LDL-C to fall within desired limits
   the range should lead to dietary and drug compliance being examined first. If these
   if considered acceptable, combination therapy or alternative treatment should be considered
   .
3. A significant increase in triglyceride levels follows
   be considered as an indication for dose reduction, drug discontinuation or combination therapy.
   or alternative therapy.

Contraindications

Description Contraindications Colestid is an automatic translation from the original language.
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COLESTID tablets are contraindicated in those persons
that have shown hypersensitivity to any of their components.

Special Warnings and Precautions

Description Special Warnings and Precautions Colestid is an automatic translation from the original language.
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Be sure to read the original instructions for the medicine from the package.
This description may contain numerous errors due to automatic translation!
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WARNINGS

No information provided.

PRECAUTIONS

Before tablet therapy
COLESTID secondary causes of hypercholesterolemia have been identified (eg, poorly controlled sugar
diabetes, hypothyroidism, nephrotic syndrome, dysproteinemias, obstructive diseases).
liver disease, other drug therapy, alcoholism), should be ruled out and a lipid
profile for assessing total cholesterol, HDL-C and triglycerides (TG).
For individuals with TG less than 400 mg/dL (<4.5 mmol/L), LDL-C levels can be estimate using the following equation:

LDL-C = Total cholesterol – [(triglycerides/5) HDL-C]

For TG levels > 400 mg/dL, this equation is less than
accurately, and LDL-C concentrations should be determined by ultracentrifugation.
Patients with hypertriglyceridemia may have low or normal LDL levels despite elevated
Total-S. In such cases, COLESTID tablets may not be indicated.

Because it sequesters bile acids,
colestipol hydrochloride may interfere with normal fat absorption and thus may reduce
absorption of folic acid and fat-soluble vitamins such as A, D, and K.

Chronic use of colestipol hydrochloride may be associated
with an increased tendency to bleed due to hypoprothrombinemia from
-for vitamin K deficiency. This usually responds quickly to parenteral vitamin K1, and
relapses can be prevented by oral administration of vitamin K1.

Serum cholesterol and triglyceride levels should be
be determined periodically based on NCEP recommendations to confirm a favorable initial
and adequate long-term response.

COLESTID tablets may cause or worsen
already existing constipation. Dosage should be gradually increased in patients
to minimize the risk of developing fecal exposure. In patients with
pre-existing constipation, the initial dose should be 2 grams once or twice a day
day. Increased fluid and fiber intake should be encouraged to help relieve
constipation and sometimes softening of the stool may be indicated. If the initial
the dose is well tolerated, the dose can be increased as needed by another 2-4
g / day (with monthly intervals) with periodic monitoring of the level of serum
lipoproteins.. If constipation worsens or the desired therapeutic response
not achieved at doses of 2 to 16 g/day, combination therapy or alternative therapy should be considered
. Particular attention should be paid to the prevention of constipation in
patients with symptomatic coronary heart disease. constipation associated with
COLESTID tablets can aggravate hemorrhoids

Although there were no reports of hypothyroidism
induced in individuals with normal thyroid function, the theoretical
the possibility exists, especially in patients with limited thyroid reserve.

Because colestipol hydrochloride is the chloride form
anion exchange resin, there is a possibility that prolonged use may lead to
development of hyperchloremic acidosis.

Carcinogenesis, Mutagenesis & Impairment of Fertility

In rat studies in which cholestyramine
resin (a bile acid isolating agent similar to colestipol hydrochloride) has been
used as a tool to investigate the role of various intestinal factors such as
fat, bile salts and microbial flora, in the development of tumors of the small and large intestines
caused by potent carcinogens, the occurrence of such tumors is observed
more cholestyramine resin in rats than in control rats.

Relevance of this laboratory observation from studies
in rats with cholestyramine resin for clinical use of tablets
Colestida unknown. In the LRC-CPPT study mentioned above, the overall frequency
fatal and non-fatal neoplasms was similar in both treatment groups. At
study of many different categories of tumors
various types of cancer of the digestive system were slightly more common in the cholestyramine group. small
figures and many categories do not allow to draw conclusions.
LRC-CPPT participants are planned to be followed up by sponsors of this study
in relation to cause-specific mortality and cancer morbidity. When is colestipol hydrochloride
introduced into the diet of rats for 18 months, there were no signs
drug-associated bowel tumor formation. In Ames’ analysis
colestipol hydrochloride was not mutagenic

Pregnancy Use

Since colestipol hydrochloride is practically not
absorbed systemically (less than 0.17% of the dose), it is not expected to
will cause harm to the fetus when administered during pregnancy at the recommended dosages.
There are no adequate and well-controlled studies in pregnant women, and
known interference with absorption of fat-soluble vitamins can be harmful
even in the presence of additives. Use of COLESTID tablets in
pregnancy or women of childbearing potential requires that potential
the benefits of drug therapy were weighed against the possible risks to the mother or
child.

Breastfeeding Mothers

Care should be taken when taking tablets
COLESTID breastfeeding mother. Possible lack of proper
vitamin absorption, as described in the Pregnancy section, may affect breastfeeding
children.

Pediatric use

Safety and efficacy in the pediatric population
not installed.

Interaction with other drugs

Description Interaction with other drugs Colestid is an automatic translation from the original language.
Do not use this information for any medical prescription or manipulation under any circumstances.
Be sure to read the original instructions for the medicine from the package.
This description may contain numerous errors due to automatic translation!
Keep this in mind and do not use this description!

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.)

Before administering COLESTID tablet

• Determine the type of hyperlipoproteinemia as described in
  Recommendations for hypercholesterolemia.
• Experiment with diet and weight loss.
• Establish baseline levels of total and LDL-C and triglycerides in serum
  levels.

When using COLESTID tablets

1. The patient must be under close clinical supervision,
   including serum cholesterol and triglyceride levels. Periodic definition
   serum cholesterol levels, as outlined in the hypercholesterolemia guidelines, should be monitored for
   confirmation of a favorable initial and long-term response.
2. Failure of total or LDL-C to fall within desired limits.
   the range should lead to dietary and drug compliance being examined first. If these
   if considered acceptable, combination therapy or alternative treatment should be considered
   .
3. A significant increase in triglyceride levels follows
   be considered as an indication for dose reduction, drug discontinuation or combination therapy.
   or alternative therapy.

HOW SUPPLIED

COLESTID Tablets yellow, elliptical, imprinted with U and
supplied as follows:

Bottles of 120 NDC 0009-0450-03
Bottles of 500 NDC 0009-0450-04

Each tablet contains 1 gram of colestipol hydrochloride.

Store at controlled room temperature between 20° and 25°C (68° to
77°F).

Common: Pharmacia

Side Effects & Drug Interactions

SIDE EFFECTS

Gastrointestinal

The most common adverse reactions are limited to
gastrointestinal tract. To achieve minimal GI disruption with optimal LDL-C levels
lowering effect, a gradual increase in dose is recommended, starting from 2 grams, one or
twice a day. Constipation is the main only complaint and
sometimes it’s hard. Most cases of constipation are mild, transient and
controlled by standard treatment. The first step should be to increase fluid intake and include
extra dietary fiber
, you can add a stool softener if needed. Some patients require dose reduction or discontinuation
therapy. Hemorrhoids may get worse.

Other less frequent gastrointestinal complaints include
abdominal discomfort (abdominal pain and cramps), intestinal gas (bloating
stomach and flatulence), indigestion and heartburn, diarrhea and loose stools, and
also nausea and vomiting. Bleeding hemorrhoids and blood in the stool have been reported infrequently
. Peptic ulcer, cholecystitis and gallstone
disease has rarely been reported in patients treated with
colestipol hydrochloride granules, and have not necessarily been drug related.

Difficulty swallowing and transient
Esophageal obstruction has rarely been reported in patients treated with COLESTID tablets.

Transient and moderate elevation
aspartate aminotransferase (AST, SGOT), alanine aminotransferase (ALT, SGPT) and alkaline
phosphatase was observed in one or more cases in various patients
treated with colestipol hydrochloride.

The following non-gastrointestinal adverse reactions
were reported in general with the same frequency in patients treated with COLESTID
Colestipol tablets, granules or placebo in clinical studies:

Cardiovascular

Uncommon chest pain, angina and tachycardia reported
.

Hypersensitivity

Rash has been reported infrequently. Urticaria and
dermatitis has rarely been reported in patients receiving
colestipol hydrochloride granules.

Musculoskeletal system

Musculoskeletal pain, pain and pain in the limbs,
joint pain and arthritis, as well as back pain.

Neurological

Headache, migraine and sinus headache reported
pain. Other infrequent complaints include dizziness,
dizziness and insomnia.

Miscellaneous

Anorexia, fatigue, weakness, shortness of breath and
swelling of the arms or legs was observed infrequently.

DRUG INTERACTIONS

Since colestipol hydrochloride is an anion exchange
resin, it may have a strong affinity for anions other than bile acids. Research In
vitro showed that colestipol hydrochloride binds a number of drug
drugs. Therefore, COLESTID tablets may delay or reduce absorption.
concomitant oral medications. Interval between receptions
COLESTID tablets and any other medicinal product should be as long as possible.
Patients should take other medications at least one hour before or four hours after taking
COLESTID tablets do not interfere with their absorption.

Repeated doses of colestipol hydrochloride given before
single dose propranolol in human studies, reduce
absorption of propranolol. However, in a subsequent study, normal subjects
single injection of colestipol hydrochloride and propranolol and
double administration within 5 days of both drugs did not affect the degree
absorption of propranolol, but had a small but statistically significant effect
on the rate of its absorption, the time to reach the maximum concentration was delayed
for about 30 minutes. Influence on the absorption of other beta-blockers
not installed. Therefore, patients taking propranolol should be observed at
COLESTID tablets either added to or removed from treatment regimen

Human studies show that absorption
chlorothiazide, reflected in urinary excretion, is markedly reduced even
when administered one hour before taking colestipol hydrochloride. Absorption
tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil
significantly decreased when co-administered with colestipol
hydrochloride, these drugs have not been tested to determine the effect
administration one hour before colestipol hydrochloride.

When colestipol hydrochloride is administered with any of the following drugs, no depressive effect on blood glucose levels has been noted in humans:
aspirin, clindamycin, clofibrate, methyldopa, nicotinic acid (niacin),
tolbutamide, phenytoin, or warfarin. Particular care should be taken with
digitalis preparations, as there are conflicting results on the effect
colestipol hydrochloride on the availability of digoxin and digitoxin.
The potential for binding these drugs with simultaneous use is present.
Stopping colestipol hydrochloride may be a health hazard if
a potentially toxic drug that is significantly bound to the tar has been
titrated to maintenance levels while the patient is taking colestipol hydrochloride

Bile acid binding resins may also prevent
absorption of oral phosphate supplements and hydrocortisone.

Study showed that cholestyramine binds bile acids
and reduces exposure to mycophenolic acid. Since colestipol also binds bile acids,
colestipol may reduce exposure to mycophenolic acid and potentially reduce
effectiveness of mycophenolate mofetil.

Side effects

Description Side effects of Colestid is an automatic translation from the original language.
Do not use this information for any medical prescription or manipulation under any circumstances.
Be sure to read the original instructions for the medicine from the package.
This description may contain numerous errors due to automatic translation!
Keep this in mind and do not use this description!

more…

Gastrointestinal

The most common adverse reactions are limited to
gastrointestinal tract. To achieve minimal GI disruption with optimal LDL-C levels
lowering effect, a gradual increase in dose is recommended, starting from 2 grams, one or
twice a day. Constipation is the main only complaint and
sometimes it’s hard. Most cases of constipation are mild, transient and
controlled by standard treatment. The first step should be to increase fluid intake and include
extra dietary fiber
, you can add a stool softener if needed. Some patients require dose reduction or discontinuation
therapy. Hemorrhoids may get worse.

Other less frequent gastrointestinal complaints include
abdominal discomfort (abdominal pain and cramps), intestinal gas (bloating
stomach and flatulence), indigestion and heartburn, diarrhea and loose stools, and
also nausea and vomiting. Bleeding hemorrhoids and blood in the stool have been reported infrequently
. Peptic ulcer, cholecystitis and gallstone
disease has rarely been reported in patients treated with
colestipol hydrochloride granules, and have not necessarily been drug related.

Difficulty swallowing and transient
Esophageal obstruction has rarely been reported in patients treated with COLESTID tablets.

Transient and moderate elevation
aspartate aminotransferase (AST, SGOT), alanine aminotransferase (ALT, SGPT) and alkaline
phosphatase was observed in one or more cases in various patients
treated with colestipol hydrochloride.

The following non-gastrointestinal adverse reactions
were reported in general with the same frequency in patients treated with COLESTID
Colestipol tablets, granules or placebo in clinical studies:

Cardiovascular

Uncommon chest pain, angina and tachycardia reported
.

Hypersensitivity

Rash has been reported infrequently. Urticaria and
dermatitis has rarely been reported in patients receiving
colestipol hydrochloride granules.

Musculoskeletal system

Musculoskeletal pain, pain and pain in the limbs,
joint pain and arthritis, as well as back pain.

Neurological

Headache, migraine and sinus headache reported
pain. Other infrequent complaints include dizziness,
dizziness and insomnia.

Miscellaneous

Anorexia, fatigue, weakness, shortness of breath and
swelling of the arms or legs was observed infrequently.

Overdose

Description Overdose Colestid is an automatic translation from the original language.
Do not use this information for any medical prescription or manipulation under any circumstances.
Be sure to read the original instructions for the medicine from the package.
This description may contain numerous errors due to automatic translation!
Keep this in mind and do not use this description!

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No overdose of COLESTID tablets has been reported.
However, in the event of an overdose, the main potential harm would be obstruction.
gastrointestinal tract. Localization of such potential obstruction,
the degree of obstruction and the presence or absence of normal bowel motility
would determine the treatment.

Colestid price

The average cost of Colestid 1 g per unit in online pharmacies is from $0.67 to $0.74, per package from $81 to $89.

The average cost of Colestid 1 gm per unit in online pharmacies is from $0.