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Common side effects of trazodone: Trazodone Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing


Trazodone Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

See also the Warning section.

Nausea, vomiting, diarrhea, drowsiness, dizziness, tiredness, blurred vision, changes in weight, headache, muscle ache/pain, dry mouth, bad taste in the mouth, stuffy nose, constipation, or change in sexual interest/ability may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To relieve dry mouth, suck on (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: shaking (tremors), nightmares, ringing in the ears, problems urinating, blood in urine, signs of infection (e.g., fever, persistent sore throat), shortness of breath, stomach/abdominal pain.

Get medical help right away if you have any very serious side effects, including: chest/jaw/left arm pain, fainting, fast/irregular heartbeat, seizures, eye pain/swelling/redness, widened pupils, vision changes (such as seeing rainbows around lights at night).

This medication may increase serotonin and rarely cause a very serious condition called serotonin syndrome/toxicity. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take (see Drug Interactions section). Get medical help right away if you develop some of the following symptoms: fast heartbeat, hallucinations, loss of coordination, severe dizziness, severe nausea/vomiting/diarrhea, twitching muscles, unexplained fever, unusual agitation/restlessness.

For males, in the very unlikely event you have a painful or prolonged erection (priapism) lasting 4 or more hours, stop using this drug and seek immediate medical attention, or permanent problems could occur.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US –

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Trazodone: MedlinePlus Drug Information

A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants (‘mood elevators’) such as trazodone during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant. Children younger than 18 years of age should not normally take trazodone, but in some cases, a doctor may decide that trazodone is the best medication to treat a child’s condition.

You should know that your mental health may change in unexpected ways when you take trazodone or other antidepressants even if you are an adult over age 24. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied abnormal excitement. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor when you are unable to seek treatment on your own.

Your healthcare provider will want to see you often while you are taking trazodone, especially at the beginning of your treatment. Be sure to keep all appointments for office visits with your doctor.

The doctor or pharmacist will give you the manufacturer’s patient information sheet (Medication Guide) when you begin treatment with trazodone. Read the information carefully and ask your doctor or pharmacist if you have any questions. You also can obtain the Medication Guide from the FDA website: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm.

No matter your age, before you take an antidepressant, you, your parent, or your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments. You should also talk about the risks and benefits of not treating your condition. You should know that having depression or another mental illness greatly increases the risk that you will become suicidal. This risk is higher if you or anyone in your family has or has ever had bipolar disorder (mood that changes from depressed to abnormally excited) or mania (frenzied, abnormally excited mood) or has thought about or attempted suicide. Talk to your doctor about your condition, symptoms, and personal and family medical history. You and your doctor will decide what type of treatment is right for you.

Trazodone (Oral Route) Side Effects

Side Effects

Drug information provided by: IBM Micromedex

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  1. Blurred vision

  2. confusion

  3. dizziness

  4. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

  5. lightheadedness

  6. sweating

  7. unusual tiredness or weakness
Less common

  1. Burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings

  2. confusion about identity, place, and time

  3. decreased concentration

  4. fainting

  5. general feeling of discomfort or illness

  6. headache

  7. lack of coordination

  8. muscle tremors

  9. nervousness

  10. pounding in the ears

  11. shortness of breath

  12. slow or fast heartbeat

  13. swelling

  1. Skin rash

  2. unusual excitement

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Dry mouth (usually mild)

  2. muscle or bone pain

  3. trouble sleeping

  4. trouble with remembering

  5. unpleasant taste
Less common

  1. Constipation

  2. continuing ringing or buzzing or other unexplained noise in the ears

  3. diarrhea

  4. hearing loss

  5. muscle aches or pains

  6. weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Portions of this document last updated: April 01, 2021

Copyright © 2021 IBM Watson Health. All rights reserved. Information is for End User’s use only and may not be sold, redistributed or otherwise used for commercial purposes.


Trazodone Potential Side Effects

Trazodone is an antidepressant sometimes used in treating depressive symptoms in bipolar disorder. It is also often prescribed to treat insomnia across a broad variety of psychiatric illnesses.

It is also used off-label to treat aggressive behavior in dementia. Trazodone was originally solid under the brand name is Desyrel; there is also an extended-release form sold under the brand name Oleptro.

Common Side Effects

These common side effects of trazodone may lessen or stop altogether once your body gets used to the medication. Check with your doctor if any of the following side effects don’t go away or are bothersome:

  • Back pain
  • Blurred vision
  • Constipation
  • Diarrhea
  • Dizziness or lightheadedness
  • Drowsiness
  • Dry mouth
  • Fatigue
  • Headache
  • Nausea

Trazodone’s sedating effect is so common that the drug is prescribed for sleep problems. Consequently, do not engage in potentially hazardous activities, including driving, until you know how this drug affects you.

Less Common Side Effects

Always notify your doctor as soon as possible if you experience any of these less common side effects.

  • Abdominal pain
  • Abnormal gait
  • Agitation
  • Amnesia
  • Bladder pain or incontinence
  • Confusion
  • Disorientation
  • Fainting (syncope)
  • Fast or slow heartbeat
  • Flushing (skin becoming red and warm)
  • Hearing problems
  • Migraine
  • Muscle aches
  • Muscle tremors
  • Muscle twitching
  • Night sweats
  • Problems with coordination or memory
  • Sensitivity to light
  • Shortness of breath
  • Skin rash
  • Speech problems
  • Tingling
  • Tinnitus
  • Unusual excitement
  • Urgent need to urinate
  • Visual disturbance
  • Vomiting

When to Seek Medical Attention

In addition to the above unusual side effects requiring a medical evaluation, painful, prolonged erection of the penis can occur after taking trazodone. Stop taking this medicine and seek emergency medical attention if this happens. This condition, called priapism, can result in permanent damage to erectile tissues if not treated promptly.

Other Rare But Serious Side Effects

Seek medical help immediately if you or a loved one experiences symptoms of these conditions:

  • Serotonin syndrome, a serious, potentially life-threatening illness caused by too much serotonin in the body
  • Hyponatremia, a low concentration of sodium in the blood

Black Box Warning

Like all antidepressants, trazodone is required to carry a warning regarding the increased possibility of suicidal thinking or behavior in young adults (24 and under), adolescents, and children. Talk to your doctor right away if you or a family member is experiencing suicidal thoughts.

Signs of Overdose

Call your doctor or a poison control center immediately if you or a loved one have potentially overdosed on trazodone. Symptoms of overdose can include:

  • Drowsiness
  • Loss of muscle coordination
  • Nausea and vomiting
  • Painful erection that does not go away
  • Respiratory arrest
  • Seizures
  • Slower or faster heartbeat

Withdrawal Symptoms

As with other antidepressants, it’s important to not discontinue trazodone without your doctor’s approval and guidance. You will likely be put on a tapering schedule so that the medication has a chance to gradually work its way out of your system, decreasing your risk for unpleasant effects. Withdrawal symptoms that may occur, especially if you stop using trazodone suddenly, include:

  • Anxiety
  • Agitation
  • Sleep disturbances

Trazodone (Desyrel) – Side Effects, Interactions, Uses, Dosage, Warnings

You should not use trazodone if you are allergic to it.

Do not use trazodone if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

After you stop taking trazodone, you must wait at least 14 days before you start taking an MAOI.

Tell your doctor if you have ever had:

  • liver or kidney disease;
  • heart disease, or a recent heart attack;
  • a bleeding or blood clotting disorder;
  • seizures or epilepsy;
  • narrow-angle glaucoma;
  • long QT syndrome;
  • drug addiction or suicidal thoughts; or
  • bipolar disorder (manic depression).

Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson’s disease, migraine headaches, serious infections, or prevention of nausea and vomiting. These medicines may interact with trazodone and cause a serious condition called serotonin syndrome.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Ask your doctor about taking this medicine if you are pregnant. It is not known whether trazodone will harm an unborn baby. However, you may have a relapse of depression if you stop taking your antidepressant. Tell your doctor right away if you become pregnant. Do not start or stop taking this medicine without your doctor’s advice.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of trazodone on the baby.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Trazodone is not approved for use by anyone younger than 18 years old.

Trazodone: Antidepressant, Sleeping Pill or Both?

What is trazodone?

Trazodone was developed in Italy in the 1960s as an antidepressant medication. Due to negative side effects associated with the drug early on—including dizziness, fainting, irregular heartbeat (and in rare cases, priapism in men)—the antidepressant wasn’t widely favored in the medical community. Eventually, however, internists and clinicians recognized potential benefits of the drug, particularly when administered at low doses. In 1981, trazodone (the generic name of the pharmaceutical) was approved by the U.S. Food and Drug Administration (FDA) under the brand name Desyrel for use in treating major depressive disorder. Today, the medication is prescribed under the brand name Oleptro to treat sleep disorders such as insomnia as well as anxiety disorder and unipolar depression.

Does trazodone cause sleepiness?

For many patients, the drug has a sedative effect, inducing a relaxed, sleepy feeling. In prescribing the drug for sleep disorders, physicians typically recommend taking a low dose at bedtime in order to limit the effects of drowsiness. Still, some people report lingering effects, including sluggishness and feeling zapped of energy, particularly upon waking.

How does trazodone help to alleviate depression?

Trazodone increases natural neurotransmitters in the central nervous system, essentially restoring depleted chemicals in the brain. One of these important neurotransmitters—serotonin—regulates our internal clock for resting and being awake, as well as mood, appetite, digestion, memory, sexual function and desire. Many experts believe depression involves an imbalance among the brain’s neurotransmitters (acetylcholine, norepinephrine, dopamine and serotonin.) While the cause of depression is not fully understood, trazodone affects the brain’s neurotransmitters by inhibiting the uptake of serotonin by nerves and stimulating other nerves.

How quickly does the drug take effect?

Patients who take the drug for a sleep disorder can experience the sedative effects within 30 minutes, depending on the type used. Patients who take the drug as an antidepressant may not notice symptom relief for one to two weeks, and it may take up to four weeks to experience the full benefits.

Is it safe to take trazodone to treat depression?

Like all medications, trazodone can cause side effects in some people. Ask your physician to discuss all potential side effects as well as drug interactions and potential withdrawal symptoms associated with the medication.

Do all antidepressant drugs work the same way?

While all antidepressant medications are designed to affect brain chemistry, various pharmaceutical formulations of the drugs have different targets and paths. The most commonly prescribed antidepressants are reuptake inhibitors. Reuptake, as described by WebMD, is “the process in which neurotransmitters are naturally reabsorbed back into nerve cells in the brain after they are released to send messages between nerve cells.” A reuptake inhibitor, then, keeps levels of neurotransmitters in the gap between nerves, potentially strengthening circuits in the brain that regulate mood. There are three different types: selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), and norepinephrine and dopamine reuptake inhibitors (NDRIs). Common SSRIs are Prozac, Zoloft, Paxil, Lexapro, Celexa and Luvox; common SNRIs include Cymbalta and Effexor; and NDRIs are found in only one drug: Wellbutrin.

Because trazodone doesn’t fall under any of these categories, it’s often referred to as an “atypical antidepressant.”

Is it safe to take trazodone for insomnia?

Although trazodone was designed to treat depression and anxiety disorders, the medication is now widely prescribed as a nighttime sleep aid for patients who suffer from acute insomnia.

How is trazodone different from other “sleeping pill” drugs?

Trazodone differs from Ambien, Sonata, Lunesta and other “sleeping pill” medications in a few ways:

  • Both Ambien and Lunesta are classified by the FDA as controlled substances because they have the potential for misuse and abuse, including dependence or addiction
  • Because trazodone is not a controlled substance, physicians aren’t limited in how many pills they can prescribe
  • It’s an inexpensive generic drug covered by most insurance companies
  • It’s not considered to be an addictive substance when used as prescribed

Trazodone should not be taken by pregnant women or women who are breastfeeding. 

What risks are associated with taking trazodone to treat depression?

There are heightened risks for patients under age 24, particularly with regard to mental health. According to Medline Plus, the following side effects and symptoms can occur among patients under age 24: “new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied abnormal excitement.” If any of these symptoms or side effects are experienced, it’s crucial to consult a physician or medical professional immediately.

It’s also imperative that patients know what to avoid while taking SSRIs, SNRIs or other antidepressants. Whether a person has a cold, is having trouble sleeping or is searching for allergy relief, they should talk to their doctor before self-treating with an over-the-counter medication. According to Psychiatry Advisor, one patient who was taking melatonin for insomnia while also prescribed an SSRI woke up with a “headache, dizziness and feeling like his face was on fire”—signs of elevated blood pressure that could have been severe had he taken higher doses. Taking an antidepressant medication in combination with supplements, such as St. John’s wort or aspirin, can increase the likelihood of upper gastrointestinal bleeding. To avoid adverse drug reactions, experts advise making a list of all medications, supplements and other OTC drugs, and sharing it with your physician prior to taking trazodone.

Is it safe to use trazodone with alcohol or other drugs?

Absolutely not. Since both alcohol and trazodone affect the central nervous system, the consequences of mixing the two can be deadly. And mixing the medication with drugs of abuse can result in the onset of serotonin syndrome, a potentially lethal adverse drug reaction. While the potential for trazodone abuse is fairly low, any amount over 600 mg. in 24 hours is an overdose.

What happens if you take too much trazodone? Can it cause serotonin syndrome?

Serotonin syndrome occurs when, according to Mayo Clinic, “high levels of serotonin accumulate in the body.” This is a drug-to-drug interaction involving the over-stimulation of central and peripheral receptors. According to the journal U.S. Pharmacist, “Serotonin syndrome (SS) is caused most often when certain antidepressant agents are taken concurrently with other drugs that modulate synaptic serotonin levels. When patients take two or more antidepressants from different pharmacologic classes, drug-drug interactions may occur; these interactions may lead to potentially severe serotonin toxicity, or serotonin syndrome.” Clinical symptoms of serotonin syndrome can develop within two hours—or up to 24 hours—after taking an increased dose or adding another serotonergic drug.

Signs and symptoms of serotonin syndrome:

  • Tremors
  • Muscle aches
  • Sweating
  • Anxiety
  • Confusion
  • Tachycardia
  • Delirium
  • Hallucinations
  • Seizures
  • Renal failure
  • Death
What are the side effects of trazodone?

Trazodone usage can cause a decrease in sodium levels in the body, a disruption of the nervous system or serotonin syndrome. The most common side effects include:

  • Drowsiness (including feeling groggy the next day)
  • Dizziness (including an increased risk of fainting/falling)
  • Dry mouth
  • Constipation
  • Headache
  • Fatigue
  • Tingling or numbness in hands, arms or legs
  • Blurred vision
  • Disorientation
  • Vertigo
  • Nasal congestion
  • Shaking
  • Anxiety
  • Muscle aches
  • Prolonged and painful erections lasting longer than six hours (priapism) 
  • Abnormally low blood pressure
  • Heart rhythm disorders 
  • Increased risk of suicidal thoughts and behavior in children and adolescents (even when taken at approved doses for depression)
  • Acting on dangerous impulses
  • Insomnia (at high doses)
  • Weight gain or loss

The drug can stay in a person’s system for 42 hours after the final dose. Higher doses can produce more severe side effects.

Can you become addicted to trazodone?

While the drug is considered non-addictive and non-habit-forming, it should only be taken as prescribed and under a physician’s care in order to avoid misuse. This is especially important for individuals who have a history of substance abuse or other drug addiction. Warning signs of drug misuse include using the sleep aid/antidepressant without a prescription, using the medication at higher doses than prescribed, or snorting or crushing the tablets to speed up the intended effects.

Can you fail a drug test while taking trazodone?

Even though the antidepressant/sleep aid is not classified as a narcotic, it can cause false positives on drug tests. According to the National Center for Biotechnology Information, “The trazodone metabolite meta-Chlorophenylpiperazine [m-CPP] can cause false-positive urine amphetamine immunoassay results.…Further, we found that patients taking trazodone can produce urine with sufficient m-CPP to result in false-positive Amphetamines II results.”

What are trazodone’s withdrawal symptoms?

Although technically a non-addictive substance, regular use of the medication can result in mild physical dependence. For this reason, trazodone withdrawal is a concern. Rather than discontinuing use “cold-turkey,” physicians typically recommend a gradual tapering. This approach is considered a better protocol to avoid potential discomfort associated with trazadone withdrawal syndrome, also known as discontinuation syndrome.

Symptoms of trazodone withdrawal include:

  • Agitation
  • Confusion
  • Rapid mood swings
  • Muscle pain
  • Weakness
  • Dizziness
  • Stomach pain
  • Sweating
  • Insomnia
  • Fatigue

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Side Effects Of Taking Trazodone For Sleep

While primarily an antidepressant, more doctors are now prescribing trazodone for sleep issues.

We’ll look today at whether or not trazodone is an effective agent for insomnia and other sleep disorders and, more importantly, whether it’s safe to use in this capacity.

Before anything else, though, what is trazodone?


What Is Trazodone

Trazodone is an antidepressant drug mainly prescribed to treat the symptoms of depression. Doctors also commonly prescribe trazodone for the treatment of anxiety, schizophrenia, and uncontrollable movements that crop up as a side effect of other meds.

First approved by the FDA in 1981 (under the brand name Desyrel), trazodone is now available as a generic medication produced by several leading drug companies. Oleptro is the only remaining brand name for trazodone.

Trazodone belongs to a class of medications called serotonin modulators. These drugs work by moderating levels of serotonin – a neurotransmitter – in the brain and increasing its availability in the CNS (central nervous system).

Categorized as a SARI (serotonin antagonist reuptake inhibitor), trazodone stops neurons from reabsorbing serotonin once the neurotransmitter has been released into the CNS. It’s through this mechanism that trazodone can help with some cases of depression.

Unfortunately, many other antidepressants are much more effective for treating depression while the chemical composition of trazodone gives it mild sedating properties, often unwanted if being used to treat depression.

So, although not designed as a sedative or hypnotic to address sleep disorders, doctors are now prescribing trazodone off-label to mitigate insomnia.

Before we move on to examine the side effects of using trazodone for sleep, what is insomnia? We’ll briefly highlight that right now.


What Is Insomnia?

There are many different types of insomnia, and the word is used to describe a range of sleep problems from difficulty falling asleep to waking up in the night and being unable to sleep again.


There are 2 broad categories of insomnia, primary and secondary:

  • Primary insomnia: With primary insomnia, you have standalone problems with sleep not brought about by other physical or psychological disorders.
  • Secondary insomnia: Difficulties sleeping caused by either a medical condition or a mental health disorder is known as secondary insomnia.


Treatment of primary insomnia involves addressing and attacking the sleep problem itself.

With secondary insomnia, the condition causing the insomnia needs to be dealt with alongside medical or behavioral treatment of the insomnia itself.


There are multiple sub-types of insomnia.

  • Acute insomnia: Typically triggered by a stressful life event, acute insomnia is a brief, fleeting episode of sleep disturbance that often resolves with no need for treatment.
  • Chronic insomnia: Insomnia is normally labelled chronic if you have problems falling asleep or staying asleep for at least 3 nights weekly over 3 months or more. There are many causes and treatment varies accordingly.
  • Comorbid insomnia: If insomnia occurs alongside another condition, it’s termed comorbid insomnia. Conditions like anxiety and depression often precipitate sleeping problems. Debilitating back pain or conditions like arthritis can also make it hard to sleep.
  • Late insomnia: Waking extremely early in the morning and being unable to sleep again.
  • Maintenance insomnia: An inability to stay asleep is known as maintenance insomnia and it’s characterized by waking during the night then finding it tough to get back to sleep.
  • Sleep onset insomnia: You’re suffering from onset insomnia if you find it tough to fall asleep when you climb into bed.


Many medications are used to address the issues that come with insomnia including Ambien and trazodone.

So, does taking an antidepressant really work if you’ve got insomnia?

Does This Help You Sleep

In 2017, a systematic review of trazodone for insomnia yielded 45 studies into the safety and efficacy of off-label use of this medication. The study concluded that trazodone is useful for treating both primary and secondary insomnia. Trazodone was also shown to be effective for treating symptoms caused by depression and dementia.

That said, physicians and sleep scientists often baulk at the idea of using antidepressants like trazodone for the treatment of insomnia. Popular alternatives like Lunesta and Ambien better deal with the neurological upset often associated with insomnia. CBT (cognitive behavioral therapy) is also promoted as an effective non-pharmacologic solution.

A key advantage of using trazodone to counter sleep issues is that it can be safely used for much longer than most common sleep aids. Normally, prescription sleeping pills are used for no more than 2 weeks. Trazodone can be safely used for longer than this.

The 3 to 6 hour half-life of trazodone makes it most suitable for treating sleep onset insomnia or maintenance insomnia.


Trazodone as a sleep aid has several core benefits:

  • Scientifically proven to effectively treat both primary insomnia and secondary insomnia
  • Trazodone can be used to treat sleep issues at low doses
  • This medication is safely than the alternative medications for elderly patients
  • You can find generic trazodone much more cheaply than Ambien
  • Trazodone has fewer side effects than most common sleep aids
  • Unlike benzodiazepines, trazodone is not addictive
  • Trazodone can be used to treat sleep apnea


Sleep scientists recommend CBT along with other appropriate behavioral modifications as a first line of attack against insomnia. If these modalities are not suitable for you or don’t work, the sedative effects of trazodone can be beneficial.

So, how much do you need?


Dosage for Sleep

Trazodone tablets come in multiple doses:

When used as a sleep aid, start off with 25 to 50mg and increase the dose if necessary up to 100mg. Studies have also shown that trazodone has utility even in lower doses.

So, you can see that trazodone works well for combatting insomnia and that you don’t need to take this non-addictive medication in high doses either.

What about the downside of trazodone for sleep, though?

We’ll look now at what side effects you can expect if trazodone is prescribed for insomnia.


Side Effects of Trazodone

If you use trazodone to alleviate insomnia and suddenly discontinue use, you might experience symptoms like anxiety, irritability, depression and mild flu-like symptoms. These side effects can be largely eliminated by slowly tapering off and using less trazodone over time.

When compared to Ambien, withdrawal symptoms are pretty mild.

How about more general side effects, then?


Experiencing any of the following is commonplace:

  • Blurred vision
  • Confusion
  • Constipation
  • Diarrhea
  • Difficulties with walking or coordination
  • Dizziness
  • Dry mouth
  • Fatigue
  • Headache
  • Lightheadedness
  • Low blood pressure
  • Muscle pain
  • Nausea or vomiting
  • Nervousness
  • Palpitations
  • Rapid heart rate
  • Sleepiness
  • Skin reactions, such as a rash
  • Tremors
  • Weight changes


While much less common, you might also experience the following serious side effects:

  • Abnormal heart rhythms
  • Anemia
  • Extrapyramidal symptoms
  • Fainting
  • Hallucinations
  • Heart attack
  • Hepatitis (liver inflammation)
  • Hypertension (high blood pressure)
  • Hypomania
  • Mania
  • Neutropenia (low white blood cell count)
  • Orthostatic hypotension (low blood pressure when standing)
  • Priapism (persistent painful erection)
  • Psychosis exacerbation
  • Seizures
  • SIADH (Syndrome of Inappropriate Anti-Diuretic Hormone secretion)
  • Stroke
  • Suicidal thoughts
  • Tardive dyskinesia
  • Worsening depression


In rare instances, trazodone can provoke serious reactions. If you find difficulty breathing or experience any other severe reaction, call 911 immediately.


According to the Food and Drug Administration, trazodone poses the following serious risks:

  • Cardiac arrhythmias: Changed in heart rhythm can occur. The risk is heightened if you have existing heart problems.
  • Serotonin syndrome: Too much serotonin accumulating in the body can trigger negative reactions. If you’re taking migraine medication or other supplements, the risk of this is magnified. Symptoms include dizziness, seizures, agitation, and hallucinations.
  • Suicidal thoughts: There’s a risk of suicidal thoughts when using trazodone. This is most prevalent in young adults.
  • Hypotension: When you stand up, hypotension is an abrupt drop in blood pressure. This happens more frequently when some people use trazodone.
  • Heightened danger of bleeding: If you’re taking blood-thinning drugs like Warfarin or Heparin along with trazodone, you should be aware that your risk of bleeding increases.
  • Mania: Trazodone can induce feelings of hyperactivity, euphoria, and excessive excitement.
  • Priapism: In very rare cases, trazodone can cause priapism, an erection that lasts a long time and causes pain.


We reiterate, you are highly unlikely to experience most of the above side effects if you use trazodone for insomnia. You should nevertheless be aware of everything that could happen.

How about overdose, then? Is this a danger with trazodone?


Trazodone Overdose

Although uncommon, there have been a handful of reports of trazodone overdose.

The risk of overdose is heightened if you’re drinking alcohol. You should also avoid taking benzodiazepines or any other CNS depressant drugs. All of these can arrest your breathing and slow your reactions.


Symptoms of a trazodone overdose include:

  • Drowsiness
  • Heart rhythm changes
  • Respiratory arrest (breathing stops)
  • Seizures
  • Vomiting


Any drug overdose can be fatal so call 911 immediately if you think you might have taken too many trazodone tablets.

If you or someone you know is struggling with an addiction to Trazodone or other antidepressants and is searching for an inpatient rehab facility, call us at 888-448-0302 to chat with a recovery specialist. We are available 24/7 to answer your questions and get you the information you need to make the best recovery decision for you. Your call is 100% confidential, and we are ready to help you get started whenever you decide that it’s the right time

Trazodone: FDA Warning

Just like a number of antidepressants, this medication has been issued with an FDA Black Box Warning.

This concerns the increased risk of suicidal thoughts or behaviors in children and young adults. The FDA states that anyone taking trazodone should be “closely monitored” and add that this medication “is not approved for use in pediatric patients”.


The Bottom Line

Despite generally positive results with trazodone for both primary insomnia and secondary insomnia, the American Academy of Sleep Medicine suggests that the potential damage and risk of using trazodone for insomnia outweigh the advantages.

Studies have shown that you might only shave off 10 minutes from the time it takes you to fall asleep, and you only reduce the amount of time you’re awake by 8 minutes. Admittedly, these are not impressive stats.

While not recommended the first line of treatment against insomnia, trazodone can be a highly effective sleep aid. If you haven’t had much luck with behavioral therapy or other types of medication from Ambien to Valium, you could find some benefit from trying trazodone.


Final Word

If you’d like advice about any aspect of medication, don’t hesitate to get in touch. Since trazodone is non-addictive and you won’t experience severe withdrawal symptoms, you won’t need residential rehab to stop taking it.

You may, however, like the idea of exploring cognitive behavioral therapy as an alternative to medication for sleep. If so, call us on 888-448-0302 and we can help you out.


Your Path to Recovery Starts Here

Recovery starts here. Talk to a Recovery Specialist now.


Your Path to Recovery Starts Here

Recovery starts here. Talk to a Recovery Specialist now.


About the Author

Landmark Recovery Staff

This post was written by a Landmark Recovery staff member. If you have any questions, please contact us at 888-448-0302.

Nov 26, 2019

Posted in: Drug

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Description TRAZODONE indications, dosages, contraindications of the active substance TRAZODONE

registered by WHO

Part of the preparations:

Pharmacological action

Antidepressant, thiazolopyridine derivative.It also has thymoleptic, anxiolytic, sedative and muscle relaxant effects. Has a high affinity for some subtypes of serotonin receptors, inhibits the reuptake of serotonin; the neuronal seizure of norepinephrine and dopamine has little effect

Has no anticholinergic effect, does not inhibit MAO, does not change body weight. Eliminates both mental (affective tension, irritability, fear, insomnia) and somatic manifestations of anxiety (palpitations, headache, myalgia, frequent urination, increased sweating).Increases the depth and duration of sleep in depressed patients, restores its physiological structure.

Reduces the pathological craving for ethanol. It is effective in patients with withdrawal symptoms in patients with drug dependence to anxiolytic drugs derivatives of benzodiazepine, eliminates anxiety-depressive state and sleep disorders (during remission, benzodiazepines can be completely replaced with trazodone). Not addictive. Promotes the restoration of libido and potency.

The therapeutic effect in 50% of patients is observed after 3-7 days, in 25% – after 2-4 weeks.


After oral administration, absorption from the gastrointestinal tract is high. The time to reach C max in blood plasma is 1-2 hours. Taking trazodone during or immediately after a meal increases absorption, reduces C max and increases the time to reach it.

Penetrates through histohematological barriers, including the BBB.Penetrates into tissues and fluids (bile, saliva, breast milk). Plasma protein binding – 89-95%.

Metabolized in the liver by hydroxylation. The isoenzymes CYP3A4, CYP3A5 and CYP3A7 are involved in the metabolism of the drug.

T 1/2 in the α-phase 3-6 hours, in the β-phase – 5-9 hours. Excreted by the kidneys – 75% in the form of inactive metabolites within 98 hours after administration; 20% – with bile.

Indication of the active substance

Various forms of depression (endogenous, psychotic, neurotic, somatogenic), incl.h / thoughts; bulimia, kleptomania, anxiety, phobias. Benzodiazepine drug dependence; acute alcohol withdrawal syndrome. Decreased libido, impotence.Prevention of migraine attacks.

Dosing regimen

The initial daily dose is 150-200 mg (in 3 divided doses). In mild forms of depression, the average maintenance dose is 150 mg / day; with moderate and severe forms – 300 mg / day. If necessary, the dose can be increased to 600 mg / day. The main part of the daily dose is recommended to be taken at bedtime.

Side effects

From the side of the central nervous system and peripheral nervous system: drowsiness, fatigue, dizziness, insomnia, headache, agitation, myalgia, impaired coordination of movements, paresthesia, disorientation, darkening of consciousness, tremor.

From the cardiovascular system: arrhythmia, conduction disturbance, bradycardia, ventricular fibrillation, decreased blood pressure, orthostatic hypotension, fainting.

From the digestive system: nausea, vomiting, diarrhea, dryness and bitterness in the mouth.

From the side of the organ of vision: visual impairment, eye irritation.

From the hematopoietic system: leukopenia, neutropenia (usually insignificant).

Other: nasal congestion, priapism followed by impotence, allergic reactions.

Contraindications to use

Ventricular arrhythmia, tachycardia, myocardial infarction (early recovery period), history of priapism, pregnancy, lactation, hypersensitivity to trazodone.

Application during pregnancy and lactation

Use during pregnancy and lactation is contraindicated.

Application for violations of liver function

Use with caution in liver failure.

Application for impaired renal function

Use with caution in renal impairment.

Use in children

Use with caution in children and adolescents under the age of 18 years.

Special instructions

Use with caution in heart disease, arterial hypotension, arterial hypertension, renal and / or hepatic failure, in children and adolescents under the age of 18 years.

Should not be used concomitantly with MAO inhibitors.

Drug interactions

A case of “pirouette” -type arrhythmia with the simultaneous use of trazodone with amiodarone is described.

A case of moderately pronounced decrease in the anticoagulant effect of warfarin while being used with trazodone is described.

With simultaneous use, it is possible to increase the concentration of digoxin in the blood plasma and develop symptoms of intoxication.

With simultaneous use with carbamazepine, a case of an increase in the concentration of carbamazepine in the blood plasma has been described.

With simultaneous use with lithium salts, tremors are possible, reversible symptoms of neurotoxic action.

When pseudoephedrine was taken against the background of trazodone therapy, a case of anxiety, panic, darkening of consciousness, depersonalization was described.

With simultaneous use with thioridazine, an increase in the concentration of trazodone in the blood plasma is possible; with tryptophan – a case of the development of anorexia, psychosis, hypomania is described; with phenytoin – a case of increased side effects of phenytoin has been described; with fluoxetine – side effects may increase; with chlorpromazine, trifluoperazine – the development of arterial hypotension is possible.

With simultaneous use with ethanol, the inhibitory effect on the central nervous system is enhanced.

Memorial Sloan Kettering Cancer Center

This document, provided by Lexicomp ® , contains all the information you need to know about the drug, including the indications, route of administration, side effects and when you should contact your healthcare provider.

Trade names: Canada

APO-TraZODone; APO-TraZODone D; DOM-TraZODone; Oleptro; PMS-TraZODone; RATIO-TraZODone [DSC]; TEVA-TraZODone; TraZODone-100; TraZODone-150; TraZODone-50


For all patients taking this drug:

  • Drugs like this have increased the likelihood of suicidal thoughts or actions in children and young people. This risk may be higher in people who have attempted suicide or have had suicidal thoughts in the past.All people taking this drug must be closely monitored. Call your doctor right away if you have signs such as depressed mood (depression), nervousness, anxiety, grumpiness, or anxiety attacks, or if other mood or behavior changes occur or worsen. Call your doctor right away if you have suicidal thoughts or attempted suicides.


  • This drug is not approved for use in children.However, your doctor may decide that the benefits of using this drug outweigh the risks associated with it. If your child has received this drug, ask the doctor about the benefits and risks. Talk to your doctor if you have any questions about how your child is using this drug.

What is this drug used for?

  • The drug is used to treat depression.
  • This medicinal product may be used for other indications.Consult your doctor.

What do I need to tell my doctor BEFORE taking this drug?

  • If you are allergic to this drug, any of its ingredients, other drugs, foods or substances. Tell your doctor about your allergy and how it manifested itself.
  • If you have recently had a myocardial infarction.
  • If you have ever had an increase in the duration of the QT interval on an ECG or other heart rhythm disturbances.
  • If you have any of the following health problems: low magnesium, low potassium, or bradycardia.
  • If you are taking any of the following drugs: linezolid or methylene blue.
  • If you have taken a drug for depression or Parkinson’s disease in the past 14 days. These include isocarboxazid, phenelzine, tranylcypromine, selegiline, or rasagiline. An episode of very high blood pressure may occur.
  • If you are taking any medication that can cause some type of heart rhythm disorder (prolonged QT interval). There are many medications that can cause these problems. If you are unsure, check with your doctor or pharmacist.

This list of drugs and diseases that may be adversely associated with this drug is not exhaustive.

Tell your doctor and pharmacist about all the medicines you take (both prescription and over-the-counter, natural products and vitamins) and your health problems.You need to make sure that this drug is safe for your medical conditions and in combination with other drugs you are already taking. Do not start or stop taking any drug or change the dosage without your doctor’s approval.

What do I need to know or do while taking this drug?

  • Tell all healthcare providers that you are taking this drug.These are doctors, nurses, pharmacists and dentists.
  • Avoid driving or other activities that require increased attention until you see how this drug affects you.
  • To reduce the risk of dizziness or loss of consciousness, get up slowly from a lying or sitting position. Use caution when climbing and descending stairs.
  • Consult your doctor before using alcohol, marijuana, or other forms of cannabis, or prescription and over-the-counter drugs that may slow you down.
  • A dangerous heart rhythm disorder (prolonged QT interval on the ECG) has happened with this drug. This may increase the likelihood of sudden death. Consult your doctor.
  • This drug may increase the risk of bleeding. Sometimes bleeding can be life-threatening. Consult your doctor.
  • The risk of eye problems may be increased in some patients with this drug. Your doctor may order you to see an ophthalmologist to see if you are at increased risk of developing these eye problems.Call your doctor right away if you have eye pain, change in vision, swelling, or redness around the eye.
  • This drug may lower sodium levels. Very low sodium levels can be life-threatening, leading to seizures, fainting, difficulty breathing, or death.
  • If you are 65 years of age or older, use this drug with caution. You may have more side effects.
  • Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.The benefits and risks for you and your child will need to be discussed.

What side effects should I report to my doctor immediately?

WARNING. In rare cases, some people with this drug can cause serious and sometimes deadly side effects. Call your doctor or get medical help right away if you have any of the following signs or symptoms, which may be associated with serious side effects:

  • Signs of an allergic reaction, such as rash, hives, itching, reddened and swollen skin with blistering or scaling, possibly associated with fever, wheezing or wheezing, tightness in the chest or throat, difficulty breathing, swallowing or speaking, unusual hoarseness, swelling in the mouth, face, lips, tongue, or throat.
  • Signs of low sodium levels such as headache, trouble concentrating, memory impairment, confusion, weakness, seizures, balance problems.
  • Signs of bleeding such as vomiting or coughing up blood; vomiting of the type of coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; non-cyclic vaginal bleeding; bruising that occurs or increases for no reason; bleeding that you cannot stop.
  • Signs of high or low blood pressure, such as very severe headache or dizziness, fainting, or vision changes.
  • Increased or abnormal heart rhythm.
  • Inflammation.
  • Confusion of consciousness.
  • Call your doctor right away if you have a painful erection or if an erection lasts more than 4 hours. This can happen even if you are not having sex at the time. If not addressed immediately, it can lead to long-term erection problems and you may not be able to have sex.
  • A serious and sometimes fatal complication called serotonin syndrome may occur. This risk may increase with the concomitant use of certain other drugs. Call your doctor right away if you develop agitation, imbalance, confusion, hallucinations, fever, tachycardia or irregular heartbeat, flushing, muscle twitching or stiffness, seizures, tremors or tremors, excessive sweating, severe diarrhea, nausea or vomiting , very severe headache.

What are some other side effects of this drug?

Any medicine can have side effects. However, many people have little or no side effects. Call your doctor or get medical help if these or any other side effects bother you or do not go away:

  • Feeling dizzy, sleepy, tired, or weak.
  • Constipation, diarrhea, abdominal pain, nausea or vomiting.
  • Dry mouth.
  • Headache.
  • Nervous tension and agitation.
  • Shiver.
  • Muscle pain.
  • stuffy nose.
  • Weight gain or loss.

This list of potential side effects is not exhaustive. If you have any questions about side effects, please contact your doctor. Talk to your doctor about side effects.

You can report side effects to the National Health Office.

You can report side effects to the FDA at 1-800-332-1088. You can also report side effects at https://www.fda.gov/medwatch.

What is the best way to take this drug?

Use this drug as directed by your healthcare practitioner. Read all the information provided to you. Follow all instructions strictly.

All forms of issue:

  • If you feel drowsy after using this drug, talk to your doctor.Your doctor may change the dose or schedule for this drug.
  • Continue taking this drug as directed by your doctor or other healthcare professional, even if you feel well.
  • It may take several weeks to achieve full effect.
  • Do not stop taking this drug suddenly without talking to your doctor. This can increase the risk of side effects. If necessary, this drug should be stopped gradually as directed by your doctor.

Immediate-release tablets:

  • This drug should be taken right after a meal or light snack.
  • The tablet can be broken in half.
  • Do not chew or crush.

Extended release tablets:

  • Take this medicine on an empty stomach.
  • Swallow whole. Do not chew or crumble.
  • Long-acting tablets can be split in half.

What to do if a dose of a drug is missed?

  • Take the missed dose as soon as you can.
  • If it is time for your next dose, do not take the missed dose and then return to your normal dose.
  • Do not take 2 doses at the same time or an additional dose.

How do I store and / or discard this drug?

  • Store at room temperature, protected from light.Store in a dry place. Do not store in the bathroom.
  • Store all medicines in a safe place. Keep all medicines out of the reach of children and pets.
  • Dispose of unused or expired drugs. Do not empty into toilet or drain unless directed to do so. If you have any questions about the disposal of your medicinal products, consult your pharmacist. Your area may have drug recycling programs.

General information on medicinal products

  • If your health does not improve or even worsens, see your doctor.
  • Do not give your medicine to anyone or take other people’s medicines.
  • Some medicines may have different patient information sheets. If you have questions about this drug, talk with your doctor, nurse, pharmacist, or other healthcare professional.
  • A separate patient instruction sheet is attached to the product. Please read this information carefully. Reread it every time you replenish your supply. If you have questions about this drug, talk with your doctor, pharmacist, or other healthcare professional.
  • If you think an overdose has occurred, call a Poison Control Center immediately or seek medical attention. Be prepared to tell or show which drug you took, how much and when it happened.

Consumer use of information and limitation of liability

This information should not be used to make decisions about taking this or any other drug. Only the attending physician has the necessary knowledge and experience to make decisions about which drugs are suitable for a particular patient. This information does not guarantee that the drug is safe, effective, or approved for the treatment of any disease or specific patient.Here are only brief general information about this drug. It does NOT contain all available information on the possible use of the drug with instructions for use, warnings, precautions, information about interactions, side effects and risks that may be associated with this drug. This information should not be construed as a treatment guide and does not replace information provided to you by your healthcare professional. Check with your doctor for complete information on the possible risks and benefits of taking this drug.


© UpToDate, Inc. and its affiliates and / or licensors, 2021. All rights reserved.

instructions for use, classification, articles »Drug guide

Application for children and adolescents

Trazodone should not be used in children and adolescents. In a clinical study in children and adolescents, suicidal behavior (attempted suicide and planning suicide) and hostility (mainly aggressiveness, protest behavior, and anger) were more common in the antidepressant group than in the placebo group.In addition, there are currently no data on the long-term safety of the drug in children and adolescents, given its effects on growth, puberty, and cognitive and behavioral development.

Suicide / suicidal ideation or clinical deterioration

Depression is associated with an increased risk of suicidal thoughts, self-harm and suicide (manifestations of suicidal behavior) by the patient. This risk persists until significant remission occurs. There may be no improvement in the condition during the first few weeks of therapy or longer.Patients should be carefully monitored until such improvement occurs. General clinical experience indicates a possible increased risk of suicide in the early stages of recovery.

It is known that patients with a history of suicidal behavior or patients who had a significant degree of suicidal thinking before starting therapy have a higher risk of developing suicidal thoughts or suicidal attempts, therefore, they need careful supervision during treatment.In a meta-analysis of placebo-controlled clinical trials of antidepressants for mental disorders, it was shown that among patients under 25 years of age, individuals in the antidepressant group had a higher risk of suicidal behavior than in the placebo group.

Drug therapy should be accompanied by careful monitoring of patients, including those from a high-risk group, especially at the beginning of treatment and after changing the dose of the drug. Patients (and their caregivers) should be warned to watch for any clinical signs of deterioration, suicidal behavior or thoughts, and unusual changes in behavior, and if they are found, seek medical advice immediately.

To minimize the potential risk of suicidal attempts, especially at the beginning of therapy, the physician should only prescribe a limited amount of trazodone to the patient at each visit.

It is recommended to carefully select the dosing regimen and carry out regular monitoring of patients with the following conditions:

  • epilepsy, particularly in such patients, do not sharply increase or decrease the dose;
  • impaired liver or kidney function, especially severe;
  • heart diseases such as angina pectoris, cardiac conduction disorders or various degrees of blockade; recent myocardial infarction
  • hyperthyroidism
  • Violation of urination, for example with prostatic hypertrophy, although such problems are not expected since the anticholinergic effect of trazodone is negligible;
  • Acute glaucoma, increased intraocular pressure, although significant changes in position are not expected because the anticholinergic effect of trazodone is negligible.

If the patient develops jaundice, trazodone therapy should be discontinued.

With the use of antidepressants in patients with schizophrenia or other psychotic disorders, psychotic symptoms may increase. Paranoid thoughts may become more pronounced. Against the background of trazodone therapy, the depressive phase in manic-depressive psychosis can change into the manic phase. In this case, the use of trazodone should be discontinued.

Against the background of simultaneous use with other serotonergic drugs, such as other antidepressants (for example, tricyclic antidepressants, selective serotonin reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors and MAO inhibitors) and antipsychotics, drug interactions with the development of serotonin malignant syndrome have been reported syndrome.Cases of fatal neuroleptic malignant syndrome have been reported with simultaneous use with antipsychotics, for which this syndrome is a known possible adverse reaction. For more information, see sections Interaction with other medicinal products and other forms of interaction and Adverse reactions.

Since agranulocytosis can clinically present as a flu-like condition, sore throat and fever, laboratory blood counts should be checked if these symptoms occur.

The occurrence of arterial hypotension, including orthostatic hypotension and syncope, has been reported in patients treated with trazodone. With the simultaneous use of antihypertensive drugs and trazodone, it may be necessary to reduce the dose of the antihypertensive drug. Elderly patients are often more susceptible to the unwanted effects of antidepressants, especially orthostatic hypotension and other anticholinergic effects.

At the end of the course of trazodone therapy, especially if this course was long, it is recommended to gradually reduce the dose until the drug is completely discontinued in order to minimize the likelihood of withdrawal symptoms, which include nausea, headache and general malaise.

There is currently no indication that trazodone hydrochloride is addictive.

During the use of trazodone, very rare cases of prolongation of the QT interval have been reported – an effect characteristic of other antidepressants. It is necessary to use trazodone with caution simultaneously with drugs with a known ability to prolong the QT interval. Trazodone should be used with caution in patients with diagnosed cardiovascular diseases, including those accompanied by lengthening of the QT interval.

Against the background of the use of powerful inhibitors of cytochrome CYP3A4, the level of trazodone in the serum may increase. For more information, see section Interaction with other medicinal products and other forms of interaction.

Like other drugs with alpha-adrenergic blocking activity, trazodone in very rare cases causes priapism. If it occurs, an intracavernous injection of an alpha-adrenergic agent such as epinephrine or metaraminol should be administered.However, cases of trazodone-induced priapism have been reported when surgery was required or when permanent sexual dysfunction resulted. In patients with suspicion of this adverse reaction, trazodone should be discontinued immediately.

Trittico sustained release tablets contain sucrose. This drug should not be used in patients with rare hereditary diseases such as fructose intolerance, glucose-galactose malabsorption syndrome or sucrase-isomaltose deficiency.


Data from a limited number (<200) of pregnant women exposed to trazodone indicate no adverse effects on pregnancy or fetal / newborn health. There is currently no other adequate epidemiological data available. Data from animal studies does not indicate the presence of any direct or indirect harmful effects of this substance, used in therapeutic doses, on the course of pregnancy, embryo / fetal development, childbirth or postnatal development of offspring.

Pregnant women should use this drug with caution. If trazodone is administered to the mother before delivery, the infant should be monitored after birth to identify possible withdrawal symptoms based on the maternal benefit / fetal risk ratio.


Limited data indicate that trazodone passes into breast milk in small quantities. Due to insufficient data, the decision to prolong / discontinue breastfeeding or continue / discontinue trazodone therapy should be made in view of the benefits of breastfeeding for the baby and the benefits of trazodone therapy for the mother.

Trazodone insignificantly or moderately affects the ability to drive vehicles and mechanisms. Patients should be warned that before driving and operating machinery, it is necessary to make sure that there is no drowsiness, sedation, dizziness, states of confusion or blurred vision while taking trazodone.

Trazodone dependence * What you need to know about trazodone dependence

Side effects and risks of trazodone

Trazodone may cause side effects in people who take it.The good news for users is that the side effects of trazodone are neither life threatening nor long lasting. However, the side effects of trazodone can be serious enough to be needed by a healthcare professional. The most common side effects of trazodone are:

  • Blurred vision
  • Drowsiness, drowsiness, dizziness or fatigue
  • sweating
  • Swelling of the body and / or face
  • Weight loss without diet
  • Nasal congestion may occur
  • Other

for taking trazodone, but they are less common.Less likely side effects include:

  • Dry mouth and throat
  • Constipation or diarrhea
  • Sexual dysfunction
  • Painful and persistent penile or clitoris erection
  • Heart arrhythmias

There are some serious side effects that can occur in people. If any of these problems occur, patients should seek immediate medical attention. These side effects include:

  • Rash / hives
  • Rapid heartbeat
  • Shortness of breath
  • Sudden dizziness
  • Feel like fainting
  • Decreased heart rate
  • Sodium bleeding


  • Easy to get blue

    Can a person overdose on trazodone?

    Users can overdose on trazodone if the medication is not taken as directed.Taking too much trazodone can lead to serotonin syndrome. This happens when serotonin builds up in the body. Signs of serotonin syndrome include:

    • Agitation / Anxiety
    • Restlessness
    • Muscle Twitching
    • Confusion
    • Elevated / Rapid Heart Rate / High Blood Pressure
    • Upset stomach
    • Cold / chills / shivering / chills on the skin

    Patients with the following symptoms should seek medical attention:

    • Fever
    • Convulsions / seizures
    • Arrhythmia
    • Coma
    • Unconsciousness

    Overdose of trazodone can be life-threatening.The medicine should not be mixed with alcohol, as this can cause death. People should not be afraid of taking trazodone if it is being used as directed.

    How to treat trazodone addiction?

    In the vast majority of cases, trazodone dependence will be present along with many other drugs. It is unusual for Trzodone to use alone. Because dependence on Transodon usually occurs along with other pharmaceutical and illegal drugs. inpatient treatment can be helpful.Thanks to an individualized treatment plan, people who want to get rid of their trazodone addiction and continue to treat their mental problems are given every opportunity to do so within the inpatient program.

    Long-term trazodone users should undergo medical detoxification to get rid of addictive drugs. Medication Assisted Treatment (MAT) is available to users seeking to get rid of drug addiction. During detoxification, MABs relieve intense withdrawal symptoms.People can focus on recovery rather than the grueling aspects of recovery. MATs have the potential to reduce the likelihood of relapse during detoxification. In all cases, after detox, complex therapy should be carried out in order to relieve a person of addiction.

    Naltrexone for trazodone addiction

    Although naltrexone is commonly used to treat severe trazodone addiction, it does not stop cravings for this drug. For this reason, naltrexone treatment for trazodone addiction usually begins after the detoxification and withdrawal phase and only under medical supervision.

    Naltrexone is a generic brand name tablet commonly prescribed under the brand names ReVia and Depade and is available in the United States, Canada and Europe. The extended release injectable formulation is often sold under the name Vivitrol and is available in different forms depending on the amount of medication needed per day.

    Another form of naltrexone is a type of implant used in treatment that is shaped like a small ball and inserted into the lower abdominal wall.Upon implantation, the device releases a constant amount of naltrexone, and the drug can also be administered as a sustained-release injection every month.

    ✚ Trittico. Professor Minutko’s neuropsychiatric clinic. Article # 5195

    Trazodone (trittico), marketed under many brand names around the world, is an antidepressant. Trittico is used to treat major depressive disorders, anxiety disorders and, in addition to other treatments, alcohol dependence.Common side effects include dry mouth, vomiting, feeling weak, and headache. More serious side effects can include suicidal thoughts, bipolar disorder, abnormal heart rhythms, and priapism. It remains unclear whether it is safe for women to use Trittico while pregnant or breastfeeding.

    Trittico is a phenylpiperazine compound for a serotonin antagonist and a reuptake inhibitor (SSRI).Trazodone also has a sedative effect.

    Trittico is a relatively old drug and the most frequently prescribed antidepressant in the public mental health system, probably due to its effective lobbying by pharmaceutical companies. Trazodone was approved for medical use in the United States back in 1981.

    Data from open and double-blind studies show that the effectiveness of the antidepressant trazodone is comparable to that of amitriptyline, doxepin and mianserin.Since trazodone has minimal anticholinergic activity, it was especially prescribed for the treatment of depressed geriatric patients when it first appeared on the market. However, the side effect of trazodone, orthostatic hypotension, which can cause dizziness and increase the risk of falling, has dangerous consequences for older patients; thus, this side effect, along with sedation, often makes trazodone less appropriate for the treatment of elderly patients than newer compounds that share a lack of anticholinergic activity but not the rest of the side effect profile.Two recent reviews found trazodone as the second most prescribed treatment for insomnia, but since most research is limited to patients with depression, few studies actually support the use of trittico in the treatment of primary insomnia.

    Note that if the patient is under 18 years of age, and trittico (trazodone) is combined with other antidepressants, this may increase the likelihood of suicidal thoughts or actions. The possibility of suicide in depressed patients persists throughout treatment and until a stable remission occurs.Trittico has been reported in the literature to induce seizures in a small number of patients who have taken this drug concurrently with seizure medication.

    Although tritico is not a true member of SSRI antidepressants, it has many SSRI properties, especially the potential for withdrawal if the drug is stopped too quickly, so it should be taken with caution when withdrawing drugs, usually in a gradual process. reducing the dose over a period of time.Since trazodone can impair the cognitive and / or physical abilities required to perform potentially hazardous tasks, such as driving a car, the patient should be warned not to engage in such activities while taking tritico.

    Due to the absence of anticholinergic side effects, trazodone is especially useful in situations where antimuscarinic effects are especially dangerous (for example, in patients with benign prostatic hyperplasia, closed glaucoma, or frequent constipation).Trazodone’s tendency to induce sedation is a double-edged sword. For many patients, relief from agitation, anxiety, and insomnia can be quick; for other patients, including those with significant psychomotor retardation and a feeling of weakened energy, trazodone may be inadmissible due to sedation. Trazodone causes orthostatic hypotension in some patients, probably as a consequence of α 1 adrenergic receptor blockade. Mania has been observed in association with trazodone treatment, including in patients with bipolar disorder as well as in patients with previous diagnoses of major depression.

    In patients taking trittico, cardiac arrhythmias arising in connection with treatment with this drug were noted, both in patients with a previously established diagnosis of mitral valve prolapse, and in patients with family history of cardiovascular disease. QT segment prolongation has been reported with trazodone therapy. During treatment with trittico, closely monitor patients with previously identified heart disease, especially with cardiac arrhythmias. Trazodone is not recommended for use during the initial recovery phase of myocardial infarction.Concomitant administration of drugs that prolong the QT interval or CYP3A4 inhibitors may increase the risk of cardiac arrhythmias.

    A relatively rare but dramatic side effect associated with trazodone is priapism, probably due to its α-adrenergic receptor antagonism. The risk of this side effect is greatest during the first month of treatment at low doses (i.e. <150 mg / day). Early recognition of any abnormal erectile function is essential (including prolonged or abnormal erections) and should prompt the patient to discontinue trazodone treatment.Clinical reports also describe Trittico-related psychosexual side effects in women, including increased libido, clitoral priapism, and spontaneous orgasms. Rare cases of idiosyncratic hepatotoxicity have been observed, possibly due to the formation of reactive metabolites. Elevated prolactin concentrations have been observed in patients taking trazodone.

    🏥 Trazodon | Side effects, dosage, uses and more 2021

    Main characteristics of trazodone

    1. Trazodone immediate-release tablet is available only as a generic preparation.
    2. An extended version of trazodone is only available as the brand name Oleptro.
    3. Trazodone is used to treat depression.

    Important warnings Real warnings

    FDA warning: suicide warning

    • Trazodone has a black box warning. This is the most serious warning from the Food and Drug Administration (FDA). The black box warning alerts doctors and patients to drug exposure that can be dangerous.
    • Drugs used to treat depression, including trazodone, may cause an increase in suicidal thoughts or actions (thoughts or behaviors that harm oneself). This risk is higher in children, adolescents, or young adults. It is also higher during the first few months of treatment with this drug or during dose changes. You and your family members, caregivers and doctors should be on the lookout for any new or sudden changes in your mood, behavior, thoughts, or feelings. If you have any changes, see your doctor immediately.
    • Serotonin Syndrome Prevention: This drug can cause a life-threatening condition called serotonin syndrome. This risk is higher when you first start taking this drug or during dose changes. Your risk may be higher if you are also taking other drugs that have similar effects, such as trazodone, such as other drugs used to treat depression. Symptoms include agitation, hallucinations (seeing or hearing something that isn’t there), confusion or trouble thinking, coma (long periods of unconsciousness), coordination problems, muscle twitching (overactive reflexes), stiff muscles, heart rate, high frequency or low blood pressure, sweating, fever, nausea, vomiting, and diarrhea.Call your doctor right away if you have these symptoms.
    • Prevention of angle-closure glaucoma: This drug may cause your pupils to be slightly larger and cause high pressure in your eyes (angle-closure glaucoma). If you are at high risk for this condition, your doctor may give you medication to help prevent it.
    • Bleeding Warning: Taking this drug with other medicines that affect your ability to stop bleeding may increase your risk of bleeding.This includes life-threatening, serious bleeding, and bleeding-related events such as nosebleeds, bruising, or skin discoloration due to bleeding below your skin. These drugs include warfarin, dabigatran, rivaroxaban, and pain drugs called nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and aspirin.

    What is trazodone?

    Trazodone Oral Tablets are a prescription drug.Trazodone Duck Immediate Release Tablet is only available as a generic drug. The drugs usually cost less. Trazodone Extended Release Tablets are only available as brand name Oleptro .

    Why is it used

    Trazodone is used to treat depression in adults.

    How it works

    Trazodone belongs to a class of drugs called antidepressants. A drug class is a group of drugs that work in a similar way.These drugs are often used to treat these conditions.

    It is not clear how trazodone works. It can increase the activity of serotonin in your brain. Serotonin is a chemical that helps maintain mental balance.

    Side effects Trazodone side effects

    Trazodone Oral Tablets may cause drowsiness or drowsiness. You should not drive, use a car, or perform other activities that require vigilance until you know how this drug is affecting you.This can cause other side effects.

    More common side effects

    More common trazodone side effects may include:

    • drowsiness
    • dizziness
    • constipation
    • blurred vision

    If these effects are mild, they may disappear within a few days or weeks. If they are more severe or persist, talk to your doctor or pharmacist.

    Serious side effects

    Call your doctor at once if you have a serious side effect.Call 911 if your symptoms feel life threatening or if you think you have a medical emergency. Serious side effects and their symptoms may include the following:

    • Suicidal thoughts and worsening depression. Symptoms include:
      • thoughts of suicide or death
      • attempted suicide
      • new or worse depression
      • new or worse alarm
      • feeling very agitated or restless
      • panic attacks
      • insomnia (sleeping problem)
      • new or worse irritability
      • acting aggressive, angry or violent
      • acting on dangerous impulses
      • mania (extreme increase in activity and talking)
      • Other unusual changes in behavior or mood
    • Serotonin Syndrome.Symptoms include:
      • agitation
      • confusion or problem thinking
      • hallucinations (seeing or hearing something does not exist)
      • coordination problems
      • fast heart rate
      • tight muscles
      • problem walking
      • nausea
      • vomiting
      • diarrhea
    • Vision problems. Symptoms include:
      • eye pain
      • changes in your vision, such as blurred vision or visual disturbances
      • swelling or redness of the eyes or around the eyes
    • Irregular or fast heartbeat or weak
    • Low blood pressure.Symptoms include:
      • dizziness or fainting when changing position, such as standing up from a seated position
    • Unusual bruising or bleeding
    • Erection lasts longer than 6 hours
    • Hyponatremia (low sodium levels in the blood), Symptoms include:
      • headache
      • weakness
      • confusion
      • concentration problems
      • memory problems
      • feeling of unsteadiness when walking

    Disclaimer: Our goal is to provide you with as much up-to-date and up-to-date information as possible.However, because drugs affect every person in a different way, we cannot guarantee that this information includes all possible side effects and does not replace medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

    Interactions Trazodone may interact with other drugs

    Trazodone Oral Tablets may interact with other medicines, vitamins, or herbs you may be taking.Interaction is when a substance changes the way we work with drugs. This can be harmful or interfere with the work of the drug.

    To avoid interactions, your doctor must carefully manage all of your medications. Be sure to tell your doctor about any medications, vitamins, or herbs you are taking. To find out how this drug might interact with something else you are taking, talk to your doctor or pharmacist.

    Drugs you should not use with trazodone

    Do not take these drugs with trazodone.This can lead to dangerous consequences in the body. Examples of these drugs include:

    • Monoamine oxidase inhibitors (MOIs) such as isocarboxazid, phenelzine, tranylcypromine, or selegiline. You should not take these drugs together or within 14 days of each other. This increases the risk of serotonin syndrome.

    Interactions that may cause more side effects

    Taking trazodone with certain medicines may cause more side effects.These drugs include:

    • Central nervous system (CNS) depressants. Trazodone may make your response to barbiturates and other CNS depressants stronger.
    • warfarin. Taking trazodone with warfarin may increase the risk of bleeding. Your doctor will monitor you closely.
    • Non-steroidal anti-inflammatory drugs (NSAIDs) or aspirin. Trazodone may increase the risk of bleeding while using these drugs.
    • Depression drugs such as citalopram, fluoxetine, paroxetine, sertraline, venlafaxine, duloxetine, fentanyl, lithium, tramadol, tryptophan, buspirone, and St. John’s wort. Taking these drugs together may increase the risk of serotonin syndrome. This condition can be life threatening.
    • digoxin. Taking trazodone with digoxin may increase the levels of digoxin in your body. This can increase the risk of side effects from digoxin. These include vomiting, dizziness, vision problems, and an irregular heart rate.Your doctor can monitor your blood digoxin levels if you take these drugs together.
    • Phenytoin. Taking trazodone with digoxin may increase the levels of phenytoin in your body. This can increase the risk of side effects from phenytoin. These include constipation, mood changes, confusion, and balance problems. Your doctor can monitor your blood levels of phenytoin if you take these drugs together.
    • Ketoconazole or ritonavir. Trazodone levels in your body may increase if you take it with ketoconazole, ritonavir, or other drugs that increase trazodone levels.This may increase the risk of side effects from trazodone. These include constipation, serotonin syndrome, and vision problems. Your doctor may lower your trazodone dosage if you are taking medications that can increase your trazodone levels.

    Interactions that may make drugs less effective

    Certain medicines can lower the level of trazodone in your body and make your dose of trazodone less effective. You may need to increase your trazodone dosage when taking with these drugs.These drugs include:

    • Phenytoin and carbamazepine

    Disclaimer: Our goal is to provide you with the most current and up-to-date information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information does not replace medical advice. Always talk with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs, and dietary supplements, and over-the-counter medications you are taking.

    Other warnings Terazodone warnings

    Trazodone Oral Tablets come with several warnings.

    Allergy Warning

    Trazodone may cause a severe allergic reaction. Symptoms may include:

    • bad breath
    • swelling of the face, tongue, eyes or mouth
    • rash, hives (itchy scars) or blisters, alone or with fever or joint pain

    If you have an allergic reaction, call your doctor or local poison control center right away.If your symptoms are severe, call 911 or go to the nearest emergency room.

    Do not take this drug again if you have ever had an allergic reaction to it. Recurrence can be fatal (cause of death).

    Interaction with alcohol

    Use of beverages containing alcohol may increase the risk of drowsiness or dizziness from trazodone. If you drink alcohol, talk to your doctor.

    Warnings for people with certain health conditions

    For people with heart disease: If you have heart disease, ask your doctor if this drug is safe for you.Taking trazodone can cause an irregular heartbeat and a long QT interval (a heart rhythm problem that can cause chaotic or abnormal heartbeats). Your doctor may monitor you closely if you are taking this drug.

    For people with obstructive glaucoma glaucoma: This drug may enlarge your pupils and may cause an angle-closure attack.

    For people with a history of mania or bipolar disorder: People with a history of bipolar disorder who are being treated with trazodone for depression may have a higher likelihood of manic episodes.If you have a history of mania or bipolar disorder, your doctor may need to use a different medication.

    Warnings for other groups

    For pregnant women: Trazodone is a pregnancy category C. This means two things:

    1. Animal studies have shown adverse effects on the fetus when the mother takes the drug.
    2. There have not been enough human studies to be sure how this drug might affect the fetus.

    Talk to your doctor if you are pregnant or planning to become pregnant. This medication should only be used if the potential benefit justifies the potential risk to the fetus. Call your doctor right away if you become pregnant while taking this drug.

    Women who are breastfeeding: Trazodone can pass into breast milk and may cause side effects in a breastfed baby. Talk with your doctor if you are breastfeeding.You may need to decide whether to stop breastfeeding or stop taking this drug.

    Seniors: The kidneys of older people may not work as well as they used to. This can cause your body to process medications more slowly. As a result, more drugs remain in your body for a longer time. This increases the risk of side effects.

    If you are over 65, you may be more likely to develop side effects with this drug.This includes hyponatremia (low blood salt levels).

    For children: The safety and efficacy of this drug in children have not been established. This medication should not be used by people under the age of 18.

    Dosage How to take trazodone

    This dosage information is for trazodone oral tablet. All possible doses and dosage forms cannot be included here. Your dose, dosage form, and how often you take the drug will depend on:

    • your age
    • condition that can be treated
    • how bad is your condition
    • other medical conditions you have
    • How do you respond to the first dose

    Forms and strengths

    General: trazodone

    • Form: Immediate-release tablet
    • Strengths: 50 mg, 100 mg, 150 mg, 300 mg

    Make: Oleptro

    • Form: Sustained-release tablet
    • Strengths: 150 mg, 300 mg

    Dosage for major depressive disorder

    Adult dose (age 18 years) and older)

    Immediate release tablet:

    • Typical starting dose: 150 mg daily in divided doses
    • Dosage increases: Your doctor may increase your dose by 50 mg per day every 3 or 4 days.
    • Maximum dose: 400 mg daily in divided doses. If you are in the hospital, the maximum dose is 600 mg per day.

    extended-release tablet:

    • Typical starting dose: 150 mg taken once daily
    • Dosage Increases: Your doctor may increase your dose by 75 mg every three days.
    • Maximum dose: 375 mg per day

    Child dosage (ages 0-17)

    This drug has not been studied in children.It should not be used in people under the age of 18.

    Disclaimer: Our goal is to provide you with the most current and up-to-date information. However, since medications affect each person differently, we cannot guarantee that this list includes all possible doses. This information does not replace medical advice. Always talk to your doctor or pharmacist about the dosages that are right for you.

    Take as directed Take as directed

    Trazodone Tablet is used for long-term treatment.It comes with serious risks if you don’t take it as directed.

    If you stop taking this drug or do not take it at all: If you stop taking this drug suddenly or do not take it, your depression may not improve. You may also have withdrawal symptoms. These include anxiety, agitation, and sleep problems. If you need to stop taking this drug, your doctor will gradually taper your dose over time.

    If you miss doses or do not take a drug on schedule: Your drug may not work or may stop working completely. For this drug to work well, a certain amount must be in your body at all times.

    If you take too much: You may have dangerous levels of trazodone in your body. Overdose symptoms of this drug may include:

    • erection lasting more than 6 hours
    • cessation of breathing
    • 90,127 withdrawals 90,128

    • changes in the way your heart functions, including prolonged QT (a heart rhythm problem that can cause chaotic or abnormal heartbeats)

    If you think you have taken too much of this drug, call your doctor or local poison control center.If your symptoms are severe, call 911 or go to the nearest emergency room right away.

    What to do if you miss a dose: Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This can lead to dangerous side effects.

    How to tell if a drug is working: You should have a decrease in your feelings of depression and your mood should improve.

    Important considerations. Important considerations. Important considerations for taking trazodone

    . Keep these considerations in mind if your doctor prescribes tabloid tablets for you.


    • Take trazodone shortly after a meal or snack.
    • You must swallow this medication whole. You can also break it in half along the score line (indented down the center of the tablet) and swallow it. Do not chew or crush trazodone tablets.
    • Not every pharmacy has all forms or brands of this drug. When filling out a prescription, be sure to call ahead.


    • Store trazodone at room temperature. Keep it between 68 ° F and 77 ° F (20 ° C and 25 ° C).
    • Keep it away from light.


    Prescription for this reusable drug. You will not need to enter a new prescription for this medication. Your doctor will write down the number of refills authorized for your prescription.


    • Always carry your medicines with you. When flying, never put it in a checked bag. Keep it in your carry bag.
    • Don’t worry about the X-ray machines at the airport. They cannot damage your medications.
    • You may need to show airport staff the pharmacy label for your medications. Always carry the original prescription-labeled box with you.
    • Do not put this medication in your car’s glove box or leave it in your car.Be sure to avoid this when the weather is very high or very cold.

    Clinical monitoring

    You and your doctor must monitor certain health problems. This can help you stay safe while you are taking this drug. These issues include:

    • Eye exam. You may be at risk of angle-closure glaucoma. Your doctor can do an eye exam and contact you if needed.
    • Mental health and behavioral problems. You and your doctor should watch for any changes in your behavior or mood. This drug may cause new mental health and behavioral problems. It can also cause problems that you already have.


    Many insurance companies require prior authorization for certain forms or brands of this drug, which means your doctor must get approval from your insurance company before your insurance company pays for the prescription.

    Alternatives Are there alternatives?

    There are other medicines available to treat your condition. Some may be better for you than others. Talk with your doctor about other drug options that might work for you.

    Disclaimer: Healthline has made every effort to ensure that all information is factually correct, comprehensive and current. However, this article should not be used as a substitute for the knowledge and experience of a licensed healthcare professional.You should always check with your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all potential uses, directions, precautions, warnings, drug interactions, allergic reactions, or side effects. The absence of warnings or other information for a given drug does not mean that the drug or drug combination is safe, effective, or appropriate for all patients or for all specific purposes.