What is the recommended Deplin dosage for different conditions. How does L-methylfolate compare to folic acid supplements. What are the potential benefits and side effects of Deplin.

Understanding Deplin and L-Methylfolate

Deplin is a prescription medical food containing L-methylfolate, the active form of folate that is readily usable by the body. It is primarily used as an adjunctive treatment for depression and to address folate deficiency in certain individuals.

What Makes Deplin Unique?

Unlike over-the-counter folic acid supplements, Deplin provides methylfolate that does not require activation by the body. This is particularly beneficial for people with genetic variations that impair folate metabolism, such as mutations in the MTHFR gene.

• Contains the bioactive form of folate (L-methylfolate)
• Bypasses the need for enzymatic conversion in the body
• May be more effective for those with impaired folate metabolism

Deplin Dosage Guidelines

The appropriate Deplin dosage can vary depending on the individual and the condition being treated. Typically, Deplin is available in two strengths:

• 7.5 mg capsules
• 15 mg capsules

For most applications, the standard starting dose is 7.5 mg daily. However, some patients may require the higher 15 mg dose for optimal results. It’s crucial to follow the dosage prescribed by your healthcare provider.

Factors Affecting Deplin Dosage

Several factors can influence the appropriate Deplin dosage for an individual:

• Severity of folate deficiency
• Presence of MTHFR gene mutations
• Concurrent medications
• Overall health status
• Response to initial treatment

Indications for Deplin Use

Deplin is primarily indicated for specific medical conditions and situations where active folate supplementation may be beneficial:

Depression Management

One of the primary uses of Deplin is as an adjunct to antidepressant therapy. How does L-methylfolate support depression treatment? It helps promote the production of neurotransmitters in the brain that affect mood, potentially enhancing the effectiveness of antidepressant medications.

Folate Deficiency

Individuals with folate deficiency, whether due to dietary factors, genetic variations, or other health conditions, may benefit from Deplin supplementation. Why is addressing folate deficiency important? Adequate folate levels are crucial for various bodily functions, including DNA synthesis and cell division.

Pregnancy and Lactation

Folate is essential during pregnancy for fetal development and preventing neural tube defects. Deplin may be prescribed to pregnant women who have difficulty metabolizing folic acid or those with a history of neural tube defects in previous pregnancies.

Comparing Deplin to Over-the-Counter Folic Acid

While both Deplin and over-the-counter folic acid aim to address folate needs, they differ in several key aspects:

Potential Benefits of Deplin

Deplin supplementation may offer several potential benefits, particularly for individuals with folate deficiency or those undergoing treatment for depression:

• Enhanced response to antidepressant medications
• Improved mood and cognitive function
• Support for cardiovascular health
• Potential reduction in homocysteine levels
• Support for healthy pregnancy outcomes

Can Deplin improve overall well-being beyond addressing specific medical conditions? While more research is needed, some individuals report increased energy levels and improved mental clarity when taking L-methylfolate supplements.

Safety and Side Effects of Deplin

Deplin is generally considered safe when taken as directed. Unlike traditional antidepressants, it typically does not cause significant side effects. In clinical trials, the side effects reported with Deplin were comparable to those observed with placebo.

Common Side Effects

While rare, some individuals may experience mild side effects when taking Deplin:

• Nausea
• Stomach upset
• Headache
• Difficulty sleeping

Is Deplin associated with serious adverse effects? Serious side effects are extremely rare with Deplin. However, as with any medication or supplement, it’s important to consult with a healthcare provider if you experience any unusual symptoms.

Drug Interactions

Deplin is generally safe to take alongside most medications, including antidepressants. However, it’s essential to inform your healthcare provider about all medications and supplements you’re taking to avoid potential interactions.

Optimizing Deplin Treatment

To get the most benefit from Deplin supplementation, consider the following tips:

1. Take Deplin consistently as prescribed
2. Follow up regularly with your healthcare provider
3. Report any side effects or changes in symptoms
4. Consider genetic testing for MTHFR mutations if indicated
5. Maintain a healthy lifestyle, including a balanced diet and regular exercise

How long does it take to see results from Deplin? The time frame can vary, but some individuals report noticing improvements in mood and energy levels within a few weeks of starting supplementation.

Accessing and Affording Deplin

As a prescription medical food, Deplin may not be covered by all insurance plans. However, there are options to help make it more affordable:

Brand Direct Health Pharmacy

The Brand Direct Health pharmacy program offers savings, support, and resources for patients prescribed Deplin. To access this program:

• Call 1-866-331-6440
• Visit www.branddirecthealth.com for more information

Patient Assistance Programs

Some pharmaceutical companies offer patient assistance programs to help individuals access necessary medications at reduced costs. Check with the manufacturer or your healthcare provider for information on available programs.

The Role of Folate in Mental Health

Understanding the connection between folate and mental health can help explain why Deplin may be beneficial for some individuals with depression or other mood disorders.

Folate and Neurotransmitter Synthesis

Folate plays a crucial role in the production of neurotransmitters that regulate mood, including serotonin, dopamine, and norepinephrine. How does folate deficiency impact mental health? Insufficient folate levels can lead to impaired neurotransmitter synthesis, potentially contributing to mood disorders and reduced response to antidepressant treatments.

The MTHFR Gene and Depression

Variations in the MTHFR gene can affect an individual’s ability to convert folic acid into its active form, L-methylfolate. This can result in functional folate deficiency, even when dietary intake is adequate. Why is this significant for mental health? MTHFR mutations have been associated with an increased risk of depression and poorer response to certain antidepressant medications.

By providing the active form of folate, Deplin may help overcome the metabolic challenges associated with MTHFR mutations, supporting optimal neurotransmitter function and potentially enhancing the effectiveness of antidepressant treatments.

Deplin in Combination with Antidepressants

For individuals with depression, Deplin is often prescribed as an adjunct to traditional antidepressant medications. This combination approach may offer several advantages:

Enhanced Efficacy

By supporting neurotransmitter synthesis, Deplin may help create an optimal environment for antidepressants to work more effectively. How does this translate to clinical outcomes? Some studies have shown improved response rates and remission rates when L-methylfolate is added to antidepressant therapy, particularly in individuals who have not responded adequately to antidepressants alone.

Potential for Dose Reduction

In some cases, the addition of Deplin may allow for a reduction in antidepressant dosage while maintaining or improving therapeutic effects. This can be particularly beneficial for patients experiencing dose-related side effects from their antidepressant medication.

Addressing Treatment-Resistant Depression

For individuals with treatment-resistant depression, adding Deplin to their existing antidepressant regimen may offer a new avenue for symptom improvement. Why might this approach be effective? By addressing potential folate deficiency or impaired folate metabolism, Deplin may help overcome one of the factors contributing to treatment resistance.

Monitoring and Adjusting Deplin Treatment

As with any medical intervention, it’s important to monitor the effects of Deplin treatment and make adjustments as needed:

Regular Follow-ups

Schedule regular check-ins with your healthcare provider to assess your response to Deplin and discuss any changes in symptoms or side effects.

Bloodwork

Your doctor may recommend periodic blood tests to monitor folate levels and other relevant markers. What can these tests reveal? They can help ensure that you’re receiving the appropriate dosage of Deplin and identify any potential issues related to folate metabolism.

Dosage Adjustments

Based on your response and any test results, your healthcare provider may adjust your Deplin dosage. This could involve increasing the dose if the initial response is inadequate or potentially decreasing the dose if high folate levels are detected.

Long-term Considerations

Discuss with your healthcare provider how long you should continue taking Deplin. For some individuals, long-term supplementation may be recommended, while others may be able to discontinue use after a certain period.

Lifestyle Factors and Folate Status

While Deplin can address folate deficiency directly, it’s also important to consider lifestyle factors that can impact folate status:

Dietary Sources of Folate

Incorporating folate-rich foods into your diet can complement Deplin supplementation. What are some good dietary sources of folate?

• Leafy green vegetables (spinach, kale, collard greens)
• Legumes (lentils, chickpeas, beans)
• Fortified grains and cereals
• Citrus fruits
• Avocados

Factors That Can Deplete Folate

Be aware of factors that can negatively impact folate levels:

• Excessive alcohol consumption
• Smoking
• Certain medications (e.g., methotrexate, some anticonvulsants)
• Chronic health conditions (e.g., celiac disease, inflammatory bowel disease)

Addressing these factors in conjunction with Deplin supplementation can help optimize your folate status and overall health.

Future Directions in L-Methylfolate Research

As interest in the role of folate metabolism in mental health continues to grow, ongoing research is exploring new applications and refining our understanding of L-methylfolate supplementation:

Personalized Medicine Approaches

Researchers are investigating how genetic factors, beyond MTHFR mutations, may influence an individual’s response to L-methylfolate supplementation. How might this impact future treatment strategies? It could lead to more personalized approaches to folate supplementation based on an individual’s genetic profile.

Expanded Applications

While Deplin is primarily used for depression and folate deficiency, studies are exploring its potential benefits in other conditions, including:

• Schizophrenia
• Bipolar disorder
• Cognitive decline and dementia
• Cardiovascular disease prevention

Optimal Dosing Strategies

Ongoing research aims to refine dosing recommendations for different populations and conditions. This may lead to more nuanced guidelines for L-methylfolate supplementation in the future.

As research in this field progresses, it’s likely that our understanding of the role of L-methylfolate in mental health and overall well-being will continue to evolve, potentially opening up new avenues for treatment and prevention strategies.

Page not found | DEPLIN®

The page you are looking for either doesn’t exist or some other error
occurred. Please check the URL or head over to the
homepage to choose another
direction.

What Is DEPLIN^®?

The DEPLIN^® Difference

Is DEPLIN^® Right for You?

Share Your Story

Resources

Save on DEPLIN^®

Frequently Asked Questions

For Healthcare Professionals

The Folate Story

Different From OTC Folic Acid

How DEPLIN^® Works

An Expert’s Perspective

Safety and Tolerability

Request a Visit

Help Patients Save on DEPLIN^®

Product Information

How can DEPLIN

^® help me?

DEPLIN^® can provide the body with already-active folate that is ready to help promote the production of natural chemicals in the brain that affect mood and help you get the most out of your antidepressant therapy.

Is DEPLIN

^® safe? What are the side effects?

Yes, DEPLIN^® is generally safe and does not have the side effects of traditional antidepressants. In clinical trials, the side effects of DEPLIN^® were about the same as those of a placebo (a pill or liquid with no active medicine, such as a sugar pill). DEPLIN^®, which is safe to take with antidepressant medications when taken as indicated, is not associated with weight gain, insomnia, or sexual dysfunction.

How is DEPLIN

^® different from over-the-counter (OTC) options?

OTC folic acid needs to be activated by your body before it can be used. Unfortunately, up to 70% of people with depression may have a compromised ability to complete this activation. DEPLIN^® capsules can provide you with already-active folate so your body does not have to activate it for you to see a benefit. DEPLIN^® addresses the body’s nutritional requirements and creates an environment that allows you to get the most out of your antidepressant therapy.

Is there a program to help me save on my prescription?

Yes, you can save on DEPLIN^® with Brand Direct Health^® pharmacy, which offers savings, support, and resources to patients. To fill your prescription through Brand Direct Health^® pharmacy, call 1-866-331-6440 or visit www.branddirecthealth.com to learn more.

Symptoms of depression can include:

• Sadness
• Loss of interest or pleasure in activities you used to enjoy
• Change in weight/appetite
• Difficulty sleeping or oversleeping
• Low concentration/Trouble making decisions
• Energy loss/Feeling slowed down
• Feelings of worthlessness
• Thoughts of death or suicide

Adapted from the MedlinePlus website.

Finding the Right Methylfolate Dosage for MTHFR

Proper Methylfolate Dosage for MTHFR Treatment

Demand for methyl-folate has surged in recent years as more and more people learn they are affected by low folate levels.

Low folate can result from certain medications, diet, alcohol, drugs, gastrointestinal disorders, or—in many cases—an MTHFR genetic mutation. In all these cases, prescription folic acid is often recommended. Doctors will also prescribe folic acid for pregnant or nursing women or to patients with treatment-resistant depression. Read on to learn why this approach does not improve health.

Folate deficiency can not only lead to depression but also hinder recovery from it. Recent studies show that folate deficiency, especially caused by genetic variability in folate metabolism, is a causative factor in resistance to antidepressant treatment.

However, folic acid is not a suitable option because the MTHFR genetic enzyme deficiency prevents the proper conversion of folate to 5-MTHF. The best option for those with MTHFR is methylfolate. 

Bioactive L-methylfolate has been shown to significantly increase blood serum folate levels when compared to folic acid.

As with any supplement, there are proper dosage levels for methylfolate.

There are many dosage guidelines for folic acid online. However, methylfolate is absorbed much more quickly than folic acid, often allowing for a lower dose. Folic acid’s effectiveness is influenced by the MTHFR genetic variants in the folate pathway that impairs conversion to its active form.

Although it is unlikely you will suffer adverse effects from taking too much methylfolate, the dosage that accompanies a particular product is there for a reason. Taking the proper dosage will ensure that you enjoy the maximum benefits.

This article will explain the proper dosage for methylfolate and how much methylfolate you should take. We’ll also discuss how to determine the right dosage for you and why people take methylfolate at all.

How Much Methylfolate Should You Take?

Understanding the general dosage for methylfolate can help you determine what is best for your own needs.

Prescription methylfolate (known as Deplin®) is available in dosages of 7. 5 mg and 15 mg. The recommended dosage for adjunctive treatment to antidepressant medication is 7.5 – 15 mg per day. The greatest effects of high-dose methylfolate in treatment-resistant depression are seen from taking 15 mg/day of methylfolate.

The dosage for treating megaloblastic anemia is also 7.5 – 15 mg per day, while the dosage for renal and hepatic disorders (moderate) is not to exceed 40 mg per day.

It’s important to note that doses greater than 0.1 mg/day may mask pernicious anemia. Doctors advise that this may cause normal blood cell count to show up in blood tests while “irreversible nerve damage” continues.

Everyone is different, and everyone metabolizes supplements differently. For some people, determining the right dose of methylfolate may be a matter of trial and error. Many Naturopaths will suggest you start low and go slow to increase your dosage amounts. However, a doctor’s prescription for Methylfolate will usually be prescribed based on the patient’s specific health problems.

How to Determine the Right Dosage of Methylfolate for You

Determining the right dosage of methylfolate begins with assessing the degree of your symptoms. For some people, symptoms of folate deficiency are their first clue that they are in need of supplementation.

Symptoms of folate deficiency typically include:

● Tiredness, fatigue, lethargy (1-4 mg of L-methylfolate)

● Muscle weakness

● Neurological signs: pins and needles, tingling, or burning, or peripheral neuropathy (numbness in the extremities) – 3 mg of L-methylfolate

● Psychological issues: depression (7.5-15 mg of L-methylfolate)

● Cognitive symptoms: poor memory, brain fog, impaired judgment and understanding, dementia/Alzheimer’s (5-6 mg of L-methylfolate)

● Gastrointestinal signs: nausea, vomiting, abdominal pain, weight loss, diarrhea, irritable bowel syndrome (IBS) (if symptoms are due to low serotonin levels, consider 7.5-15 mg of L-methylfolate)

● Headache and dizziness

● Pallor

● Shortness of breath

However, because symptoms of mild folate deficiency are often mild, testing is often a much more accurate means of determining your folate status. This can provide a better picture of how depleted you may be. In addition, some of the symptoms mentioned above (headache, dizziness, shortness of breath) are also symptoms of anemia, so it may be necessary to test for Vitamin B12 deficiency as well.

A plasma test can measure the amount of folate in the liquid portion of your blood. This can help show how much folate you’re getting from supplements and your diet. The folate blood test will also measure your levels of folic acid (which is also known as unmetabolized folic acid), tetrahydrofolate (THF), folinic acid, and methylfolate.

However, a more accurate way to measure folate levels is to test the amount in your red blood cells. This will show the amount of folate in your body when the cell was made, which can indicate your levels over the past four months. Unlike the plasma test, the red blood cell test is not usually affected by the amount of folate and folic acid you are consuming each day.

Why Use L-Methylfolate for MTHFR Treatment?

L-methylfolate plays a crucial role in many bodily processes. It is necessary for DNA synthesis and various methylation reactions, including the conversion of homocysteine to methionine. It is also required for repairing DNA, turning genes on and off, and creating neurotransmitters.

Low levels can lead to a range of health conditions, including megaloblastic anemia, pancytopenia, glossitis, angular stomatitis, oral ulcers, neuropsychiatric disorders(depression, irritability, insomnia, cognitive decline, fatigue, and psychosis).

However, ordinary folic acid supplements may not provide the full spectrum of effects for those who are unable to convert folate to its biologically active form due to an MTHFR mutation. Instead, folic acid must be broken down and methylated through a complicated four-step process.

In addition, folic acid supplements can result in intakes above the Tolerable Upper Intake Level.

L-5-Methyltetrahydrofolate(L-methylfolate, or 5-MTHF) is the preferred form of the nutrient as it is the predominant active form in the body. L-methylfolate is the only folate that can cross the blood-brain barrier, which means it is suitable for those with the MTHFR polymorphism, vegans, vegetarians, the elderly, or those with malabsorption issues.

Taking methylfolate alongside antidepressants can significantly boost the effectiveness of the medication. This form is able to bypass the conversion step mediated by the MTHFR enzyme(methylenetetrahydrofolate reductase). This means that L-methylfolate supplements can be given as a means of improving serum and Central Nervous System (CNS) folate levels, particularly in assisting with the response to antidepressant medication.

One study involving patients with schizophrenia measured the benefits of L-methylfolate over folic acid. After receiving 15 mg of L-methylfolate for 12 weeks, L-methylfolate significantly increased plasma methylfolate levels compared to placebo. The patients also showed improvements in many cognitive tasks.

instructions for use, dosages, composition, analogues, side effects / Pillintrip

900 07

Page reviewed by pharmacist Fedorchenko Olga Valerievna Last update 2022-03-12

Attention!
The information on this page is for healthcare professionals only!
The information is collected from open sources and may contain significant errors!
Be careful and double-check all the information on this page!

Top 20 drugs with the same ingredients:

Gyno-TardyferonFolbiolFerronemiaFolicilFysiofolBialferFolavitMaltofer FolMaterfolFeofolFolicronTardyferon FolFefolFolimenUniferolFolic AcidFolviteGyno TardyferonFolasHuma-Folaci d

Top 20 drugs with the same use:

Maxifol 5000FolsanHBHHAcide Folique ArrowFegemFol LichtensteinFolacFolivitalPediafolicFolsäure-ratiopharmAcfolAcide Folique CCDAndreafolFilicineAcido Folico A. M.AcifolFolaci dFolic Acid-Tsiteli AFolimaxFolin

Name of the drug

The information provided in section Name of the drug Deplin is based on data from another medicine with exactly the same composition as the drug Deplin . Be
carefully and be sure to specify the information under section Name of the drug
in the instructions for the drug Deplin directly from the package or from the pharmacist at the pharmacy.

more…

Deplin

Composition

The information provided in section Composition of Deplin is based on data from another medicine with exactly the same composition as medicine Deplin . Be
carefully and be sure to specify the information on section Composition
in the instructions for the drug Deplin directly from the package or from the pharmacist at the pharmacy.

more…

Folic Acid

Therapeutic Indications

The information provided in Therapeutic Indications Deplin is based on data from another medicine with exactly the same composition as Deplin . Be
carefully and be sure to check the information under section Therapeutic indications
in the instructions for the medicine Deplin directly from the package or from the pharmacist at the pharmacy.

more…

Film-coated tablets; Dragee; Substance; Substance powder

Tablets

folate deficiency anemia;

Hypo- and avitaminosis of folic acid (including with tropical sprue, celiac disease, malnutrition).

treatment and prevention of folic acid deficiency due to unbalanced or malnutrition;

treatment and prevention of anemia due to folic acid deficiency: macrocytic hyperchromic anemia, anemia and leukopenia caused by drugs and ionizing radiation, megaloblastic anemia, postresection anemia, sideroblastic anemia in the elderly, anemia associated with diseases of the small intestine, sprue and malabsorption syndrome ;

treatment and prevention of anemia during pregnancy and lactation;

during pregnancy – prevention of the development of neural tube defects in the fetus;

long-term treatment with folic acid antagonists (methotrexate, a combination of sulfamethoxazole and trimethoprim), anticonvulsants (phenytoin, primidone, phenobarbital).

Dosage and Administration

The information provided in section Dosage and Administration Deplin is based on data from another medicine with exactly the same composition as medicine Deplin . Be
carefully and be sure to check the information on section Dosage and administration
in the instructions for the drug Deplin directly from the package or from the pharmacist at the pharmacy.

more…

Film-coated tablets; Dragee; Substance; Substance powder

Tablets

Int.

Folate deficiency anemia: adults and children of any age starting dose – 1 mg / day. At high doses, resistance may occur.

Maintenance treatment: neonatal 0.1 mg/day; for children under 4 years old – 0.3 mg / day; for children over 4 years old and adults – 0.4 mg / day; during pregnancy and lactation – from 0.1 to 0. 8 mg / day.

With hypo- and avitaminosis of folic acid (depending on the severity of avitaminosis): adults – up to 5 mg / day; children – in smaller doses depending on age. The course of treatment is 20-30 days.

With concomitant alcoholism, hemolytic anemia, chronic infectious diseases, after gastrectomy, malabsorption syndrome, liver failure, liver cirrhosis, stress, the dose of the drug should be increased to 5 mg / day.

Treatment of megaloblastic anemia due to folic acid deficiency – 5 mg / day for 4 months, prevention – 2.5 mg / day.

Prevention and treatment of macrocytic anemia in malabsorption, inflammatory bowel disease and unbalanced or malnutrition – 15 mg / day, in patients with sprue – 5-15 mg / day.

Prevention of the development of neural tube defects in the fetus – 2.5 mg / day for 4 weeks before the expected pregnancy, continue taking it during the first trimester of pregnancy.

Higher maintenance doses may be given to patients suffering from alcoholism, as well as to patients with chronic infections and taking anticonvulsants.

Contraindications

The information provided in section Contraindications Deplin is based on data from another medicine with exactly the same composition as medicine Deplin . Be
carefully and be sure to check the information on section Contraindications
in the instructions for the drug Deplin directly from the package or from the pharmacist at the pharmacy.

more…

Film-coated tablets; Dragee; Substance; Substance-powder

Tablets

hypersensitivity to drug components;

B ₁₂ – deficiency anemia;

sucrase deficiency;

isomaltase deficiency;

fructose intolerance;

glucose-galactose malabsorption;

children’s age (up to 3 years).

Precautions: folate deficiency anemia with cyanocobalamin deficiency.

hypersensitivity to drug components;

pernicious anemia;

malignant neoplasms;

cobalamin deficiency.

Adverse effects

The information provided in section Adverse effects Deplin is based on data from another medicine with exactly the same composition as Deplin . Be
carefully and be sure to check the information in section Side effects
in the instructions for the drug Deplin directly from the package or from the pharmacist at the pharmacy.

more…

Film-coated tablets; Dragee; Substance; Substance powder

Tablets

Allergic reactions – skin rash, pruritus, bronchospasm, erythema, hyperthermia.

Allergic reactions: possible development of skin rashes, itching, erythema, bronchospasm.

From the gastrointestinal tract: anorexia, nausea, bloating, bitterness in the mouth.

Overdose

Provided in Section Overdose Deplin information based on data from another medicine with exactly the same composition as Deplin . Be
carefully and be sure to specify the information on section Overdose
in the instructions for the drug Deplin directly from the package or from the pharmacist at the pharmacy.

more…

Film-coated tablets; Dragee; Substance; Substance Powder

Tablets

Doses of folic acid up to 4–5 mg are well tolerated. Higher doses may cause CNS and GI disturbances.

No cases of overdose have been reported.

Pharmacodynamics

The information provided in section Pharmacodynamics Deplin is based on data from another medicine with exactly the same composition as the drug Deplin . Be
carefully and be sure to clarify the information in section Pharmacodynamics
in the instructions for the drug Deplin directly from the package or from the pharmacist at the pharmacy.

more…

Film-coated tablets; Dragee; Substance; Substance-powder

Tablets

Vitamin B group (vitamin B _c , vitamin B ₉ ), can be synthesized and is necessary for the normal maturation of megaloblasts and the formation of normoblasts. Participates in the synthesis of amino acids (including glycine, methionine), nucleic acids, purines, pyrimidines, in the metabolism of choline, histidine.

Vitamin B. In the body it is converted into tetrahydrofolic acid, which is involved in various metabolic processes as a coenzyme and is necessary for the normal maturation of megaloblasts and the formation of normoblasts. With a deficiency of folic acid, a megaloblastic type of hematopoiesis develops. Stimulates erythropoiesis, participates in the synthesis of amino acids (including methionine, serine, glycine), nucleic acids, purines, pyrimidines, in the metabolism of choline, histidine. During pregnancy, it performs a protective function in relation to the action of teratogenic and fetal-damaging factors. Contributes to the normal maturation and functioning of the placenta.

Pharmacokinetics

The information provided in section Pharmacokinetics Deplin is based on data from another medicine with exactly the same composition as the drug Deplin . Be
carefully and be sure to specify the information on section Pharmacokinetics
in the instructions for the drug Deplin directly from the package or from the pharmacist at the pharmacy.

more…

Film-coated tablets; Dragee; Substance; Substance-powder

Tablets

Folic acid is well and completely absorbed in the gastrointestinal tract, mainly in the upper duodenum (even in the presence of malabsorption syndrome against the background of tropical sprue).

Intensively binds to plasma proteins. Penetrates through the BBB, the placenta, and also into breast milk. T _max – 30-60 min. It is deposited and metabolized in the liver with the formation of tetrahydrofolic acid (in the presence of ascorbic acid under the action of dihydrofolate reductase).

Excreted by the kidneys mainly as metabolites. If the accepted dose significantly exceeds the daily requirement for folic acid, then it is excreted unchanged.

Eliminated by hemodialysis.

After oral administration, folic acid, combining in the stomach with the internal factor of Castle (a specific glycoprotein), is well and completely absorbed in the gastrointestinal tract. Almost completely bound to plasma proteins.

Deposited and metabolized in the liver with the formation of tetrahydrofolic acid (in the presence of ascorbic acid under the action of the enzyme dihydrofolate reductase). Penetrates through the BBB, the placenta and into breast milk. C _max in the blood is achieved in 30–60 minutes. It is excreted by the kidneys both unchanged (if the accepted dose significantly exceeds the daily requirement), and in the form of metabolites. Excreted by hemodialysis. 5 mg of folic acid taken orally is excreted from the body after 5 hours.0072 . Be
carefully and be sure to check the information on section Interaction
in the instructions for the drug Deplin directly from the package or from the pharmacist at the pharmacy.

more…

Film-coated tablets; Dragee; Substance; Substance powder

Tablets

Anticonvulsants (including phenytoin and carbamazepine), estrogens, oral contraceptives increase the need for folic acid.

Antacids (including calcium, aluminum and magnesium preparations), cholestyramine, sulfonamides (including sulfasalazine) reduce the absorption of folic acid.

Methotrexate, pyrimethamine, triamterene, trimethoprim inhibit dihydrofolate reductase and reduce the effect of folic acid (calcium folinate should be given instead in patients using these drugs).

There is no definitive information regarding zinc preparations: some studies show that folate inhibits zinc absorption, others do not.

When used simultaneously with chloramphenicol, neomycin, polymyxins, tetracyclines, the absorption of folic acid is reduced.

With simultaneous use, folic acid reduces the effects of oral contraceptives, ethanol, sulfasalazine, cycloserine and glutethimide, methotrexate, phenytoin, primidone, chloramphenicol.

Folic acid may decrease plasma levels of phenobarbital, phenytoin, or primidone and cause an epileptic seizure.

Decreased or altered absorption may occur with co-administration of cholestyramine and folic acid, so folic acid should be taken 1 hour before or 4 to 6 hours after cholestyramine.

Pharmacological group

The information provided in section Pharmacological group Deplin is based on data from another medicine with exactly the same composition as drug Deplin . Be
carefully and be sure to clarify the information in section Pharmacological group
in the instructions for the drug Deplin directly from the package or from the pharmacist at the pharmacy.

more…

Film-coated tablets; Dragee; Substance; Substance powder

Tablets

• Hemopoiesis stimulants
• Vitamins and vitamin-like preparations

• Vitamin; hematopoiesis stimulator [Hematopoiesis stimulants]
• Vitamin; hematopoiesis stimulant [Vitamins and vitamin-like products]

Deplin price

We don’t have exact price data for this medicine.
However, we will provide data for each active ingredient

The average cost of Folic Acid 5 mg per unit in online pharmacies is from $0.25 to $0.84, per package from $25 to $92.

The average cost of Folic Acid 1 mg per unit in online pharmacies is from $0.21 to $0.21, per package from $21 to $21.

Sources:

• https://www.drugs.com/mtm/deplin.html
• https://pubmed.ncbi.nlm.nih.gov/?term=deplin

Find in country:

A

B

C

D

D

E

W

I

Y

900 02 K

L

M

H

O

R

R

S

T

Y

F

X

H

Sh

E

Yu

I

Deplin (L-Methylfolate [from Metafolin] and Algae-S Powder [Schizochytrium] Therapeutic Nutrition Prescription): Uses, Dosage, Side Effects, Interactions, Warning

Full

• Generic Name: l-methylfolate [from metafolin] and seaweed powder [schizophrenia] Prescription Health Nutrition
• Brand Name: Complete

• Product description
• Indications and dosage
• Side effects and drug interactions
• Warnings and precautions
• Overdose and contraindications
• Clinical pharmacology
• Medication Guide

Product Description

FULL 7. 5 capsules

FULL 15 capsules

DESCRIPTION

DEPLIN is a prescription medical food for use only under the supervision of a physician for the clinical dietary treatment of depression and schizophrenia and is specifically formulated to meet the specific nutritional requirements of these conditions.

Each DEPLIN 7.5 capsule contains 7.5 mg of L-methylfolate (from Metafolin) and 90.314 mg of Algae-S powder (Schizochytrium). CAS No. 151533-22-1

Each DEPLIN 15 capsule contains 15.0 mg of L-methylfolate (from Metafolin) and 90.314 mg Algae-S powder (Schizochytrium). CAS No. 151533-22-1

how much milk thistle per day

Ingredients

COMPLETE 7.5

Silicified Microcrystalline Cellulose, Algae-S Powder (Schizochytrium Algae Oil [vegetable source], Glucose Syrup Solids, Mannitol, Sodium Caseinate (Milk), Soy Protein, High Oleic Sunflower Oil, 2% or less sodium ascorbate, tricalcium phosphate, tetrasodium diphosphate, natural flavors, soy lecithin, and a mixture of natural tocopherols and ascorbyl palmitate [as antioxidants]), Pullulan, calcium L-methylfolate, titanium dioxide [color], magnesium stearate (vegetable source), FD&C Yellow #6 [color], FD&C Red #40 [color], propylene glycol, sodium hydroxide, povidone, FD&C Yellow #6 Aluminum Lake, Shellac. Contains milk and soy

FULL 15

Siliconized microcrystalline cellulose, Algae-S powder (Schizochytrium algae oil [vegetable source], glucose syrup solids, mannitol, sodium caseinate (milk), soy protein, high sunflower oil oleic acid, 2% or less sodium ascorbate, tricalcium phosphate, tetrasodium diphosphate Natural flavors, soy lecithin and mixed natural tocopherols and ascorbyl palmitate [as antioxidants]), pullulan, calcium L-methylfolate, titanium dioxide [color], magnesium stearate (vegetable source) )], FD&C Yellow #6 [color], FD&C Red #40 [color], propylene glycol, sodium hydroxide, povidone, shellac. Contains milk and soy

DEPLIN is a medical prescription food for use only under medical supervision.

missed periods on sprintec birth control

Medical foods are intended for patients who have a limited or impaired ability to take in, digest, absorb, or metabolize common foods or certain nutrients, or who have other special medical nutritional requirements for which dietary regulation cannot be achieved by modifications. just a normal diet. ¹ This product is not an Orange Book product.

RECOMMENDATIONS

1. US Food and Drug Administration 21 CFR 101.9(j)(8).

Adverse effects and drug interactions

SIDE EFFECTS

Allergic reactions have been reported following oral administration of L-methylfolate. ¹¹

DRUG INTERACTIONS

Information not provided

which drug propofol

RECOMMENDATIONS

11. Natural Standards Collaboration (NIH). Folate (Folic Acid) 2009 Monograph.

PRECAUTIONS

General

L-methylfolate (DEPLIN) is not interchangeable with folic acid. In some patients, folic acid is not effective in influencing folic acid levels in the brain due to the low rate of transport of folic acid across the blood-brain barrier and/or low levels in the brain of an enzyme needed to convert folic acid into a biological and functional form. ^7-9

Patients at risk of vitamin B12 deficiency should consult their physician before taking L-methylfolate.