Dextromethorphan mucinex. Mucinex DM: Comprehensive Guide to Uses, Side Effects, and Dosage
What are the main uses of Mucinex DM. How does Mucinex DM work to relieve cough and congestion. What are the potential side effects of Mucinex DM. How should Mucinex DM be taken properly. Are there any precautions to consider when using Mucinex DM.
Understanding Mucinex DM: A Powerful Combination for Respiratory Relief
Mucinex DM is a combination medication designed to address multiple symptoms associated with respiratory illnesses. This potent formulation contains two active ingredients: guaifenesin and dextromethorphan. Each component plays a specific role in providing relief from cough and congestion, making Mucinex DM a popular choice for those suffering from various breathing difficulties.
The Dual Action of Mucinex DM
How does Mucinex DM work to provide relief? The medication’s effectiveness lies in its two-pronged approach:
- Guaifenesin: An expectorant that thins and loosens mucus in the airways
- Dextromethorphan: A cough suppressant that reduces the urge to cough by acting on the brain’s cough center
This combination allows Mucinex DM to address both the root cause of congestion and the resulting cough, providing comprehensive relief for those suffering from respiratory issues.
Primary Uses and Applications of Mucinex DM
Mucinex DM is primarily used to alleviate coughs associated with various respiratory conditions. When is Mucinex DM typically prescribed or recommended? The medication is commonly used for:
- Common cold
- Bronchitis
- Other breathing illnesses causing cough and congestion
By targeting both mucus production and cough reflex, Mucinex DM offers a comprehensive solution for those seeking relief from persistent respiratory symptoms.
Effectiveness in Different Age Groups
Is Mucinex DM suitable for all age groups? The medication’s use is subject to certain age restrictions:
- Not recommended for children under 6 years old
- The sustained-release formulation is not advised for children under 12 years unless specifically directed by a doctor
- Adults and children over 12 can use Mucinex DM as directed
It’s crucial to consult with a healthcare professional before administering Mucinex DM to children, as cough and cold medications can pose risks in younger age groups.
Proper Administration and Dosage Guidelines
Ensuring the correct usage of Mucinex DM is essential for maximizing its benefits while minimizing potential risks. How should Mucinex DM be taken for optimal results?
- Take the medication orally with or without food
- Follow the recommended dosage of one dose every 12 hours
- Consume with a full glass of water
- Do not exceed 2 doses in 24 hours
- Swallow tablets whole or split if scored; do not crush or chew
Why is it important to maintain proper hydration while taking Mucinex DM? Drinking plenty of fluids helps break up mucus and clear congestion, enhancing the medication’s effectiveness.
Dosage Considerations
The appropriate dosage of Mucinex DM can vary based on several factors. What determines the correct dosage for an individual?
- Age
- Medical condition
- Response to treatment
It’s crucial to adhere to the recommended dosage and not increase it without consulting a healthcare professional. Improper use or abuse of Mucinex DM can lead to serious health consequences, including brain damage, seizures, or even death.
Potential Side Effects and Adverse Reactions
While Mucinex DM is generally well-tolerated, it’s important to be aware of potential side effects. What are the most common side effects associated with Mucinex DM use?
- Dizziness
- Drowsiness
- Nausea
- Vomiting
These side effects are typically mild and transient. However, if they persist or worsen, it’s advisable to consult a healthcare provider.
Serious Adverse Reactions
While rare, serious allergic reactions to Mucinex DM can occur. What symptoms should prompt immediate medical attention?
- Rash
- Itching or swelling, especially of the face, tongue, or throat
- Severe dizziness
- Difficulty breathing
If any of these symptoms manifest, it’s crucial to seek medical help immediately, as they may indicate a severe allergic reaction requiring urgent intervention.
Important Precautions and Considerations
Before starting Mucinex DM, it’s essential to consider various factors that may affect its safety and efficacy. What precautions should be taken when using Mucinex DM?
- Inform your healthcare provider about any allergies, especially to guaifenesin or dextromethorphan
- Disclose your complete medical history, particularly regarding breathing problems, liver issues, or persistent cough with blood or excessive mucus
- Be aware of potential interactions with alcohol or marijuana, which can enhance drowsiness and dizziness
- Avoid driving or operating machinery until you know how the medication affects you
Why is it crucial to provide a comprehensive medical history before taking Mucinex DM? This information helps healthcare providers assess the medication’s suitability and potential risks for each individual, ensuring safe and effective use.
Special Populations and Considerations
Certain groups may require additional precautions when using Mucinex DM. Who should exercise extra caution or consult a healthcare provider before using this medication?
- Pregnant women
- Breastfeeding mothers
- Elderly individuals
- People with chronic health conditions
These populations may be more susceptible to side effects or may require dosage adjustments to ensure safe use of Mucinex DM.
Interactions with Other Medications and Substances
Mucinex DM can interact with various medications and substances, potentially altering its effectiveness or increasing the risk of side effects. What are some important interactions to be aware of?
- Other cough and cold medications containing similar ingredients
- Alcohol
- Certain antidepressants, particularly MAO inhibitors
- Medications that cause drowsiness, such as sedatives or tranquilizers
To minimize the risk of interactions, it’s crucial to inform your healthcare provider about all medications, supplements, and herbal products you’re currently taking.
Avoiding Duplicate Treatments
Why is it important to avoid taking multiple cough and cold products simultaneously? Using multiple products with similar ingredients can lead to unintentional overdose and increased risk of side effects. Always check the active ingredients in any over-the-counter medications you’re considering and consult with a pharmacist if unsure.
Long-term Use and Monitoring
While Mucinex DM can provide effective relief for cough and congestion, it’s not intended for long-term use without medical supervision. How long can Mucinex DM be safely used?
- Generally, it’s recommended for short-term use, typically not exceeding 7 days
- If symptoms persist or worsen after a week of use, medical attention should be sought
Prolonged use of Mucinex DM without medical guidance can mask underlying health conditions or lead to dependence on the medication.
Signs to Seek Medical Attention
What symptoms indicate a need for medical evaluation while using Mucinex DM?
- Persistent cough that doesn’t improve after 7 days of treatment
- Cough accompanied by a headache that doesn’t go away
- Fever
- Severe sore throat
- Rash
- Worsening of symptoms despite medication use
These symptoms may indicate a more serious underlying condition that requires professional medical assessment and potentially different treatment approaches.
Alternative Approaches to Symptom Management
While Mucinex DM can be effective for many individuals, it’s not the only option for managing cough and congestion. What are some alternative approaches to consider?
- Increasing fluid intake to thin mucus naturally
- Using a humidifier to add moisture to the air
- Trying saline nasal drops or sprays to relieve nasal congestion
- Employing non-pharmacological methods like steam inhalation or chest physiotherapy
- Exploring natural remedies such as honey for cough relief (in adults and children over 1 year)
These alternatives can be used alone or in conjunction with Mucinex DM, depending on the severity of symptoms and individual preferences. Always consult with a healthcare provider before combining treatments.
Lifestyle Modifications for Respiratory Health
Beyond medication, what lifestyle changes can support respiratory health and potentially reduce the need for cough and cold medications?
- Quitting smoking or avoiding secondhand smoke
- Maintaining good indoor air quality
- Practicing regular hand hygiene to prevent viral infections
- Getting adequate sleep and managing stress
- Eating a balanced diet rich in vitamins and antioxidants
These lifestyle modifications can strengthen the respiratory system and immune function, potentially reducing the frequency and severity of respiratory illnesses.
Reporting Side Effects and Seeking Medical Advice
Monitoring for side effects and knowing when to seek medical advice is crucial for the safe use of Mucinex DM. How can users report side effects or get medical guidance?
- In the United States, side effects can be reported to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch
- In Canada, side effects can be reported to Health Canada at 1-866-234-2345
- For medical advice about side effects, users should contact their healthcare provider
Reporting side effects not only helps individuals receive appropriate care but also contributes to the ongoing monitoring of medication safety and effectiveness.
When to Consult a Healthcare Professional
While Mucinex DM is available over-the-counter, there are situations where professional medical advice is warranted. When should you consult a healthcare provider regarding Mucinex DM use?
- Before starting the medication if you have pre-existing health conditions
- If symptoms don’t improve or worsen after 7 days of use
- If you experience severe or persistent side effects
- If you’re unsure about potential drug interactions
- If you’re pregnant, breastfeeding, or considering use in children
Healthcare providers can offer personalized advice, assess the appropriateness of Mucinex DM for your situation, and suggest alternative treatments if necessary.
Storage and Handling of Mucinex DM
Proper storage and handling of Mucinex DM are essential for maintaining its effectiveness and safety. How should Mucinex DM be stored?
- Keep at room temperature, away from light and moisture
- Store in a secure location, out of reach of children and pets
- Do not store in the bathroom, as humidity can affect the medication
- Keep in its original container with the label intact
Adhering to these storage guidelines helps preserve the medication’s potency and prevents accidental ingestion by children or pets.
Proper Disposal of Unused Medication
What’s the correct way to dispose of unused or expired Mucinex DM?
- Check for local medication take-back programs in your area
- If unavailable, mix the medication with an undesirable substance (e.g., used coffee grounds) and place in a sealed container before disposing in household trash
- Remove or obscure any personal information on the empty medication container before discarding
- Do not flush medications down the toilet unless specifically instructed to do so
Proper disposal helps prevent environmental contamination and reduces the risk of accidental ingestion or misuse by others.
Mucinex DM Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing
Uses
This combination medication is used to relieve coughs caused by the common cold, bronchitis, and other breathing illnesses. Guaifenesin belongs to a class of drugs known as expectorants. It works by thinning and loosening mucus in the airways, clearing congestion, and making breathing easier. Dextromethorphan belongs to a class of drugs known as cough suppressants. It acts on a part of the brain (cough center) to reduce the urge to cough.If you are self-treating with this medication, it is important to read the package instructions carefully before you start using this product to be sure it is right for you. (See also Precautions section.)Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. This product (sustained-release) is not recommended for use in children younger than 12 years unless specifically directed by the doctor. Ask your doctor or pharmacist for more details about using your product safely. These products do not cure or shorten the length of the common cold and may cause serious side effects. To decrease the risk for serious side effects, carefully follow all dosage directions. Do not use this product to make a child sleepy. Do not give other cough-and-cold medication that might contain the same or similar ingredients (see also Drug Interactions section). Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms (such as drinking enough fluids, using a humidifier or saline nose drops/spray).
How to use Mucinex DM
Take this medication by mouth with or without food, as directed by your doctor, usually every 12 hours with a full glass of water. If you are self-treating, follow all directions on the product package. If you have any questions, ask your doctor or pharmacist.
Dosage is based on your age, medical condition, and response to treatment. Do not take more than 2 doses in 24 hours. Do not increase your dose or take this drug more often than directed.
Do not crush or chew this medication. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.
Drink plenty of fluids while taking this medication. Fluids will help to break up mucus and clear congestion.
Improper use of this medication (abuse) may result in serious harm (such as brain damage, seizure, death). Do not increase your dose, take it more frequently, or use it for a longer time than directed.
Tell your doctor if your cough returns, or if it is accompanied by headache that doesn’t go away, fever, severe sore throat, rash, or if it lasts or gets worse after 7 days. These may be signs of a serious medical problem. Get medical help right away if you think you may have a serious medical problem.
Side Effects
Dizziness, drowsiness, nausea, and vomiting may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US –
In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Precautions
Before taking this drug, tell your doctor or pharmacist if you are allergic to guaifenesin or dextromethorphan; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (such as emphysema, chronic bronchitis, asthma, smoker’s cough), cough with blood or large amounts of mucus, liver problems.
This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
It is unknown if guaifenesin or dextromethorphan passes into breast milk. Discuss the risks and benefits with your doctor before breast-feeding.
Interactions
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.
Taking certain MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking isocarboxazid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, or tranylcypromine during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Ask your doctor when to start or stop taking this medication.
A product that may interact with this drug is: rolapitant.
Guaifenesin and dextromethorphan are available in both prescription and nonprescription products. Check the labels of all your medications to make sure you are not taking more than one product containing guaifenesin or dextromethorphan.
Guaifenesin can affect the results of certain lab tests (such as urine levels of certain acids). Make sure laboratory personnel and all your doctors know you use this drug.
Does Mucinex DM interact with other drugs you are taking?
Enter your medication into the WebMD interaction checker
Overdose
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: extreme drowsiness, blurred vision, confusion, hallucinations, slow/shallow breathing, seizures.
If your doctor prescribed this medication, do not share this medication with others.
Keep all medical and lab appointments.
This medication is for temporary use only. Do not take this medication for more than 7 days unless your doctor tells you to do so. Tell your doctor if your condition lasts longer than 7 days.
If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Images
Mucinex DM 60 mg-1,200 mg tablet,extended release 12 hr
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This medicine is a tablet
Mucinex DM 30 mg-600 mg tablet,extended release 12 hr
Color: yellow,whiteShape: ovalImprint: Mucinex 600
This medicine is a tablet
Mucinex DM 60 mg-1,200 mg tablet,extended release 12 hr
Color: Shape: Imprint:
This medicine is a tablet
Mucinex DM 30 mg-600 mg tablet,extended release 12 hr
Color: yellow,whiteShape: ovalImprint: Mucinex 600
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
Indication-specific dosing for Mucinex DM, Robitussin Peak Cold Cough+Chest Congestion DM, Delsym Cough + Chest Congestion dextromethorphan; guaifenesin in combination … and more
amitriptyline and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug.
amoxapine and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug.
buspirone and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug.
citalopram and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug. Combination may increase risk of serotonin syndrome or neuroleptic malignant syndrome-like reactions.
clomipramine and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug.
desipramine and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug.
dextromethorphan and desvenlafaxine both increase serotonin levels. Avoid or Use Alternate Drug.
doxepin and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug.
duloxetine will increase the level or effect of dextromethorphan by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.
duloxetine and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug.
escitalopram and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug.
fluoxetine will increase the level or effect of dextromethorphan by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.
fluoxetine and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug.
fluvoxamine and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug.
grapefruit will increase the level or effect of dextromethorphan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.
imipramine and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug.
levomilnacipran and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug.
linezolid and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug. Linezolid may increase serotonin as a result of MAO-A inhibition. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, whichever comes first.
lofepramine and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug.
dextromethorphan and lorcaserin both increase serotonin levels. Avoid or Use Alternate Drug.
maprotiline and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug.
memantine, dextromethorphan.
Either increases toxicity of the other by pharmacodynamic synergism. Contraindicated.
dextromethorphan and meperidine both increase serotonin levels. Avoid or Use Alternate Drug.
methylene blue and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug. Methylene blue may increase serotonin as a result of MAO-A inhibition. If methylene blue must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Serotonergic therapy may be resumed 24 hours after last methylene blue dose or after 2 weeks of monitoring, whichever comes first.
milnacipran and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug.
nefazodone and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug.
nortriptyline and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug.
paroxetine will increase the level or effect of dextromethorphan by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.
paroxetine and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug.
protriptyline and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug.
selegiline transdermal and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug.
sertraline and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug.
dextromethorphan and St John’s Wort both increase serotonin levels. Avoid or Use Alternate Drug.
trazodone and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug.
trimipramine and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug.
venlafaxine will increase the level or effect of dextromethorphan by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug.
venlafaxine and dextromethorphan both increase serotonin levels. Avoid or Use Alternate Drug.
dextromethorphan, vilazodone.
Either increases toxicity of the other by serotonin levels. Avoid or Use Alternate Drug. Concomitant therapy should be discontinued immediately if signs or symptoms of serotonin syndrome emerge and supportive symptomatic treatment should be initiated. .
5-HTP and dextromethorphan both increase serotonin levels. Modify Therapy/Monitor Closely.
abiraterone increases levels of dextromethorphan by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Avoid coadministration of abiraterone with substrates of CYP2D6. If alternative therapy cannot be used, exercise caution and consider a dose reduction of the CYP2D6 substrate.
almotriptan and dextromethorphan both increase serotonin levels. Modify Therapy/Monitor Closely.
amphetamine, dextromethorphan.
Either increases effects of the other by serotonin levels. Use Caution/Monitor. Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when amphemtamines are coadministered with dextromethorphan. .
dextromethorphan, aripiprazole. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
artemether/lumefantrine will increase the level or effect of dextromethorphan by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
dextromethorphan, asenapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
bupropion will increase the level or effect of dextromethorphan by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
dextromethorphan, cariprazine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
clobazam will increase the level or effect of dextromethorphan by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Lower doses of drugs metabolized by CYP2D6 may be required when used concomitantly.
dextromethorphan, clozapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
cocaine topical and dextromethorphan both increase serotonin levels. Modify Therapy/Monitor Closely.
desvenlafaxine will increase the level or effect of dextromethorphan by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Desvenlafaxine inhibits CYP2D6; with higher desvenlafaxine doses (ie, 400 mg) decrease the CYP2D6 substrate dose by up to 50%; no dosage adjustment needed with desvenlafaxine doses
dexfenfluramine and dextromethorphan both increase serotonin levels. Modify Therapy/Monitor Closely.
dextroamphetamine, dextromethorphan.
Either increases effects of the other by serotonin levels. Use Caution/Monitor. Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when amphemtamines are coadministered with dextromethorphan. .
dextromethorphan, dextroamphetamine transdermal.
Either increases effects of the other by serotonin levels. Modify Therapy/Monitor Closely. Initiate with lower doses and monitor for signs and symptoms of serotonin syndrome, particularly during initiation or dosage increase. If serotonin syndrome occurs, discontinue dextroamphetamine transdermal and concomitant serotonergic drug(s).
dextroamphetamine transdermal, dextromethorphan.
Either increases effects of the other by serotonin levels. Use Caution/Monitor. Monitor for signs and symptoms of serotonin syndrome/serotonin toxicity (eg, hyperreflexia, clonus, hyperthermia, diaphoresis, tremor, autonomic instability, mental status changes) when amphemtamines are coadministered with dextromethorphan. .
dextromethorphan and dihydroergotamine both increase serotonin levels. Modify Therapy/Monitor Closely.
dextromethorphan and dihydroergotamine intranasal both increase serotonin levels. Modify Therapy/Monitor Closely.
eletriptan and dextromethorphan both increase serotonin levels. Modify Therapy/Monitor Closely.
dextromethorphan and ergotamine both increase serotonin levels. Modify Therapy/Monitor Closely.
dextromethorphan and fenfluramine both increase serotonin levels. Modify Therapy/Monitor Closely.
fenfluramine, dextromethorphan.
Either increases effects of the other by serotonin levels. Use Caution/Monitor. Coadministration with drugs that increase serotoninergic effects may increase the risk of serotonin syndrome.
dextromethorphan, fluphenazine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
frovatriptan and dextromethorphan both increase serotonin levels. Modify Therapy/Monitor Closely.
dextromethorphan, haloperidol. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
dextromethorphan, iloperidone. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
dextromethorphan and isoniazid both increase serotonin levels. Modify Therapy/Monitor Closely.
dextromethorphan and L-tryptophan both increase serotonin levels. Modify Therapy/Monitor Closely.
letermovir increases levels of dextromethorphan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
dextromethorphan and lithium both increase serotonin levels. Modify Therapy/Monitor Closely.
dextromethorphan, loxapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
dextromethorphan, loxapine inhaled. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
dextromethorphan and lsd both increase serotonin levels. Modify Therapy/Monitor Closely.
lumefantrine will increase the level or effect of dextromethorphan by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
dextromethorphan, lurasidone. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
dextromethorphan and mirtazapine both increase serotonin levels. Modify Therapy/Monitor Closely.
dextromethorphan, molindone. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
dextromethorphan and morphine both increase serotonin levels. Modify Therapy/Monitor Closely.
naratriptan and dextromethorphan both increase serotonin levels. Modify Therapy/Monitor Closely.
dextromethorphan, olanzapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
dextromethorphan, paliperidone. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
panobinostat will increase the level or effect of dextromethorphan by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Panobinostat can increase the levels and effects of sensitive CYP2D6 substrates or those with a narrow therapeutic index CYP2D6.
pazopanib increases levels of dextromethorphan by decreasing metabolism. Use Caution/Monitor.
peginterferon alfa 2b, dextromethorphan. Other (see comment). Use Caution/Monitor.
Comment: When patients are administered peginterferon alpha-2b with CYP2D6 substrates, the therapeutic effect of these drugs may be altered. Peginterferon alpha-2b may increase or decrease levels of CYP2D6 substrate.
dextromethorphan and pentazocine both increase serotonin levels. Modify Therapy/Monitor Closely.
dextromethorphan, perphenazine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
dextromethorphan, pimavanserin. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
dextromethorphan, pimozide. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
dextromethorphan, quetiapine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
quinidine will increase the level or effect of dextromethorphan by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.
dextromethorphan, risperidone. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
rizatriptan and dextromethorphan both increase serotonin levels. Modify Therapy/Monitor Closely.
rolapitant will increase the level or effect of dextromethorphan by affecting hepatic enzyme CYP2D6 metabolism. Modify Therapy/Monitor Closely. Monitor for adverse reactions when unable to avoid coadministration with narrow therapeutic index CYP2D6 substrates.
dextromethorphan and SAMe both increase serotonin levels. Modify Therapy/Monitor Closely.
sumatriptan and dextromethorphan both increase serotonin levels. Modify Therapy/Monitor Closely.
sumatriptan intranasal and dextromethorphan both increase serotonin levels. Modify Therapy/Monitor Closely.
dextromethorphan, thiothixene. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
dextromethorphan and tramadol both increase serotonin levels. Modify Therapy/Monitor Closely.
dextromethorphan, trifluoperazine. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
dextromethorphan, ziprasidone. unspecified interaction mechanism. Use Caution/Monitor. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators, which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).
zolmitriptan and dextromethorphan both increase serotonin levels. Modify Therapy/Monitor Closely.
instruction, composition, dosage, side effects
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Mucinex: instructions, composition, dosage, side effects
Mucinex is an expectorant that helps with coughs and chest congestion caused by colds, flu and allergies. Each tablet contains dextromethorphan hydrobromide, a cough suppressant, and guaifenesin, which thins mucus and bronchial secretions in the lungs.
Mucinex: instructions for use
1. Composition:
Active ingredient: guaifenesin, dextromethorphan.
2. Special instructions:
- Follow all directions on the medicine label and package.
- Tell your doctor about all illnesses, allergies, and medications you take.
- Do not take Mucinex if you are allergic to any of the ingredients in this medicine.
- If you are pregnant or breastfeeding, consult your doctor before taking this medicine.
- Mucinex may cause dizziness and slow reactions, it is not recommended to drive a vehicle in this condition.
3. Drug interactions:
Guaifenesin (an expectorant) has no known significant drug interactions.
Dextromethorphan has several important drug interactions. Some of them can be dangerous or even deadly. Before taking any medicine containing dextromethorphan, it is recommended that you check with your doctor or pharmacist about possible drug interactions, even if they are “safe enough” and available without a prescription.
First of all, dextromethorphan should never be taken with monoamine oxidase inhibitors (MAOIs or MAOIs). It is recommended to stop taking any MAOI at least 14 days before taking dextromethorphan. The combination can cause mild or fatal serotonin syndrome.
Mild and severe cases of serotonin syndrome can also be caused by combining dextromethorphan with a number of other types of drugs. These include antidepressants, opioid painkillers, amphetamines, nausea medicines, migraine medicines, ADHD medicines, Parkinson’s disease medicines, and some herbal supplements such as St. John’s wort, ginseng, and tryptophan.
4. Method of administration and dosage:
The tablet should be taken orally with a sufficient amount of water.
For stomach problems, the drug is recommended to be taken with food.
Mucinex tablets are divided into two categories with fast and prolonged action.
If the condition does not improve after 7 days of treatment, seek medical advice.
Adult Dose:
The recommended dose of Mucinex is one to two long-acting tablets (600 mg) or one rapid-release tablet (1200 mg) taken by mouth every 12 hours. Do not take more than 2.4 g/day.
Pediatric Dosage:
Quick Release Formulation:
2 to 5 years: 50 to 100 mg every 4 hours as needed, up to a maximum of 600 mg per day.
6 to 11 years: 100 to 200 mg every 4 hours as needed, up to a maximum of 1.2 g/day.
12 years and older: 200 to 400 mg every 4 hours as needed, up to a maximum of 2.4 g/day.
Long-acting formulation:
2 to 5 years: 300 mg 12 hours apart. The maximum dose is 600 mg per day.
6 to 11 years: 600 mg 12 hours apart, up to a maximum of 1. 2 g per day.
12 years and older: 600 to 1200 mg 12 hours apart, up to a maximum of 2.4 g per day.
4.1. Missed dose:
Since cough or cold medicine is taken when needed, it is not necessary to follow the schedule.
If taking medication on a regular basis, take the missed dose as soon as you remember.
Do not take a double dose to make up for a missed one.
5. Side effects:
Seek immediate medical attention if you develop signs of an allergic reaction: hives; labored breathing; swelling of the face, lips, tongue, or throat.
Common side effects may include:
- Dizziness, headache;
- Rash;
- Nausea, vomiting, indigestion.
6. Storage conditions:
Store in closed packaging at room temperature, out of the reach of children and animals.
Do not use after the expiry date which is stated on the packaging.
7. Manufacturer:
Reckitt Benckiser LLC, USA
Instructions for the use of medicinal products are posted on this site for the purpose of familiarization. Remember that taking medications should be carried out only on the recommendation of a doctor.
If you have used this medicine, please leave your review below.
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Dosage, forms and benefits of Mucinex DM | SingleCare – Product Information
Home >> Product Information >> Dosage, forms and strengths of Mucinex DM
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Forms and strengths of Mucinex DM | For adults | For children | Dosage table of Mucinex DM | With wet and dry cough | For pets | How to take Mucinex DM | FAQs
Mucinex DM is an over-the-counter combination drug that relieves cough and chest congestion caused by colds, flu and allergies. Each tablet combines dextromethorphan hydrobromide, a cough suppressant, with guaifenesin, a drug that thins mucus and bronchial secretions in the lungs. Guaifenesin has a short duration of action, which is why each Mucinex Bi-Layer Tablet contains both immediate and extended release versions of guaifenesin to ensure long-term effectiveness. Mucinex DM is taken orally every 12 hours and is available in regular and maximum dosages.
RELATED: Find out more about Mucinex | Get Discounts Mucinex
Dosage, Forms & Strengths Mucinex DM
Mucinex DM is taken as both immediate and extended release bilayer tablets.
- Mucinex DM tablets: 600 milligrams (mg) guaifenesin, 30 mg dextromethorphan hbr tromethorphan
Adult dosage of Mucinex DM
The standard recommended dose of Mucinex DM is one to two regular strength tablets (600/30 mg) or one maximum strength tablet (1200/60 mg) taken by mouth every 12 hours.
- Standard dosage of Mucinex DM for adults: 600/30-1200/60 mg (one to two regular dosage tablets or one maximum dosage tablet) every 12 hours.
- Maximum adult dosage of Mucinex DM: 1200/60 mg (two regular strength tablets or one maximum strength tablet) every 12 hours
Pediatric dosage of Mucinex DM use in adults and children from 12 years and older. it is not to be given to children under 12 years of age.
- Standard dose of Mucinex DM for children 12 years of age and older: 600/30-1200/60 mg (one to two regular-dose tablets or one maximum-dose tablet) every 12 hours.
- Maximum dose of Mucinex DM for children 12 years of age and older: 1200/60 mg (two regular strength tablets or one maximum strength tablet) every 12 hours
Mucinex DM is not available in pediatric formulations. However, both guaifenesin and dextromethorphan, the active ingredients in Mucinex DM, are approved for children aged 4 years and older. Instead of Mucinex DM, Mucinex offers two pediatric products for children aged 4+ that combine guaifenesin and dextromethorphan: Mucinex Children’s Cough, available as a flavored liquid or flavored granules, and Mucinex Children’s FreeForm Mucus and Cough, sold as a flavored liquids. . None of these products contain sustained-release guaifenesin, so doses are given every four hours.
Dosage table Mucinex DM Indication Initial dosage 9017 8 Standard dosage Maximum dosage Wet and dry cough Tablet 600/30 mg one once every 12 hours. 600/30-1200/60 mg (2 regular tablets or 1 maximum dosage tablet) once every 12 hours. 1200/60 mg once every 12 hours and not more than 2400/120 mg (4 regular tablets or 2 maximum strength tablets) per day indicated to relieve productive (wet) and unproductive (dry) cough caused by colds, flu or allergies. An expectorant (guaifenesin) helps loosen and loosen mucus in the lung passages, making coughs more productive. A cough suppressant (dextromethorphan) reduces the intensity and frequency of coughing.
- Usual dosage of Mucinex DM for wet or dry cough: 600/30-1200/60 mg (one to two regular dosage tablets or one maximum dosage tablet) every 12 hours.
- Maximum dosage of Mucinex DM for wet or dry cough: 1200/60 mg (two regular strength tablets or one maximum strength tablet) every 12 hours
Mucinex DM pet dosage
OTC drugs such as Mucinex DM should not be given to animals without first consulting a veterinarian. Doses can be too high, and human medicines contain inactive ingredients that can be harmful to animals.
The active ingredients Mucinex DM, guaifenesin and dextromethorphan are used in animals. For dextromethorphan, the standard dose is 0.5–2 mg dextromethorphan per kilogram of body weight every six to eight hours for both cats and dogs. This is between 0.23 and 0.9mg per pound of body weight. The standard dose of guaifenesin for cats and dogs is 3-5 mg per kg of body weight (1.35-2.25 mg per pound) every eight hours.
There is at least one over-the-counter veterinary cough medicine containing both guaifenesin and dextromethorphan that is similar to Mucinex DM. The manufacturer’s recommended dosage is one tablet (50mg/5mg) every four hours for small dogs and cats and one tablet (100mg/10mg) every four hours for large dogs. Although this product is available without a prescription, a veterinarian should be consulted first. Coughing in an animal may be a symptom of a more serious condition requiring veterinary attention rather than symptom relief.
How to take Mucinex DM
Mucinex DM is taken orally as tablets. It can be taken with or without food.
- Take a tablet with a full glass of water.
- Do not crush, chew, or break the tablet.
The following tips will help ensure the safe and effective use of Mucinex DM:
- Follow the instructions on the medication label. Do not take more than directed.
- Store at room temperature (68 to 77 degrees Fahrenheit).
- Always check the expiration date on the packaging of Mucinex DM. If the medicine has expired, dispose of it safely and purchase a new container.
- Do not use Mucinex DM if you are using a prescription MAO inhibitor such as Marplan (isocarboxazid) or Nardil (phenelzine). Combining dextromethorphan with an MAO inhibitor can be dangerous and even fatal. If you’re not sure if a drug is an MAO inhibitor, talk to your doctor, pharmacist, or other health care provider to help identify your prescription drugs.
- Mucinex DM helps thin sputum and thin mucus in the lungs. Drinking extra fluids and keeping the air moist with a humidifier or vaporizer will also help thin the mucus in the lung passages.
- The manufacturer, Reckitt Benckiser, advises any pregnant or breastfeeding woman to consult a physician before taking Mucinex DM.
- Cough may be a sign of a more serious illness. If the cough is chronic, recurrent, lasts more than seven days, has too much sputum, or is accompanied by other symptoms such as fever or headache, seek professional medical attention.
Dosage FAQ for Mucinex DM
How long does Mucinex DM last?
Mucinex DM combines both immediate release and extended release active ingredients so effects should start relatively quickly and last up to 12 hours. Both active ingredients, guaifenesin and dextromethorphan, will begin to show effects in 15-30 minutes. Both are quickly absorbed by the digestive system and begin to work as soon as they enter the bloodstream.
How long does Mucinex DM stay in your body?
Mucinex DM is an outer tablet that contains immediate release versions of the two active ingredients guaifenesin and dextromethorphan. The internal tablet slowly releases guaifenesin over the next 12 hours. Cough relief should last about 12 hours.
Guaifenesin, the expectorant in Mucinex DM, is rapidly eliminated from the body, with a half-life of only one hour. The half-life of a drug is the time it takes for the body to eliminate half of the drug. However, the extended release format in Mucinex DM allows the drug to be continuously released into the body over a longer period, so the effect lasts for about 12 hours.
However, dextromethorphan is different. With a half-life of three hours for many people to over a day for 1 in 10 people, dextromethorphan can be active from 11 hours to over a day. To complicate matters, dextromethorphan is converted by the body into dextrorphan, a very similar drug that also stops coughing. Dextrorphan has its own half-life. Once you get all that sorted out, both dextromethorphan and dextrorphan are usually cleared out within two days of the last dose of Mucinex DM.
What happens if I miss a dose of Mucinex DM?
Mucinex DM is taken to relieve symptoms, so a missed dose is not a problem. Just take the missed dose when you become aware of it. However, remember that taking a missed dose will reset the dosing clock. Do not take the next dose until at least 12 hours after the missed dose. Never take extra medicine to make up for a missed dose.
How do I stop taking Mucinex DM?
When used correctly, Mucinex DM can be withdrawn without any problems. Dextromethorphan, the cough medicine for Mucinex DM, is often abused and can cause psychological dependence. When chronically taken in high doses, dextromethorphan can cause physical and psychological withdrawal symptoms.
Mucinex DM is not intended for permanent or chronic use. People with chronic cough due to asthma, smoking, emphysema, or chronic bronchitis should talk to a doctor or other healthcare professional before taking Mucinex DM. For others, if symptomatic cough persists for more than seven days, stop taking Mucinex DM and seek medical attention. You should also stop taking Mucinex DM if:
- Cough returns.
- Cough accompanied by other symptoms such as fever, headache or rash.
- Any signs of an allergic reaction, such as swelling, hives, or difficulty breathing.
What is the maximum dosage of Mucinex DM?
The maximum dose of Mucinex DM is 1200 mg/60 mg every 12 hours up to 2400 mg/120 mg in one day. The maximum 12-hour dose is two regular Mucinex DM tablets or one Maximum Strength Mucinex DM tablet.
What interacts with Mucinex DM?
Mucinex DM can be taken with or without food. Food does not affect absorption of the cough medicine, dextromethorphan, although taking guaifenesin on a full stomach may slow absorption into the body.
Guaifenesin, the expectorant in Mucinex DM, has no known significant drug interactions.
But dextromethorphan is different. It has several important drug interactions. Some of them can be dangerous or even deadly. Before taking any medicine containing dextromethorphan, it is recommended that you check with your doctor, pharmacist, or other healthcare professional about possible drug interactions, even though it can be purchased without a prescription.
First of all, dextromethorphan should never be taken with monoamine oxidase inhibitors (MAOIs or MAOIs). The FDA recommends that you stop taking any MAOI at least 14 days before taking dextromethorphan. The combination can cause mild or fatal serotonin syndrome, a disease that results in an excess of serotonin, a chemical that transmits nerve signals.
Mild and severe cases of serotonin syndrome can also be caused by combining dextromethorphan with a number of other types of drugs. These include antidepressants, opioid painkillers, amphetamines, nausea medicines, migraine medicines, ADHD medicines, Parkinson’s disease medicines, and some herbal supplements such as St. John’s wort, ginseng, and tryptophan. Again, if you are unsure, check with your doctor, pharmacist, or other health care provider before taking dextromethorphan.
Resources:
- Mucinex DM, Epocrates
- Mucinex DM Drug Facts, US National Library of Medicine
- Mucinex website
- Dextromethorphan, Epocrates 9000 5
- Guaifenesin, Epocrates
- Guaifenesin Product Summary, Physician’s Digital Handbook
- Interactions between over-the-counter drugs and psychotropic drugs, LOUSE.