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Difference between excedrin and tylenol. Excedrin Extra Strength vs. Tylenol Extra Strength: Detailed Comparison

What is the difference between Excedrin Extra Strength and Tylenol Extra Strength? Get a detailed comparison of their uses, ratings, side effects, and more.

Excedrin Extra Strength vs. Tylenol Extra Strength: Key Differences

Excedrin Extra Strength and Tylenol Extra Strength are both over-the-counter pain relievers, but they have some key differences:

Active Ingredients

Excedrin Extra Strength contains a combination of acetaminophen, aspirin, and caffeine, while Tylenol Extra Strength contains only acetaminophen.

Approved Uses

Excedrin Extra Strength is approved for the treatment of osteoarthritis, migraines, and general pain/fever, while Tylenol Extra Strength is approved for sciatica, muscle pain, pain, and fever.

Ratings and Reviews

Excedrin Extra Strength has an average rating of 7.1 out of 10 on Drugs.com, with 67% of reviewers reporting a positive effect. Tylenol Extra Strength has an average rating of 5.9 out of 10, with 48% of reviewers reporting a positive effect.

Excedrin Extra Strength: Overview

Excedrin Extra Strength is an over-the-counter pain reliever that contains a combination of acetaminophen, aspirin, and caffeine. It is primarily used for the treatment of osteoarthritis, migraines, and general pain/fever. Excedrin may also be used for purposes not listed in its medication guide.

Excedrin Extra Strength Ratings and Reviews

Excedrin Extra Strength has an average rating of 7.1 out of 10 on Drugs.com, based on 39 reviews. 67% of reviewers reported a positive effect, while 31% reported a negative effect.

Tylenol Extra Strength: Overview

Tylenol Extra Strength is an over-the-counter pain reliever that contains only acetaminophen as its active ingredient. It is an effective mild pain reliever with a low risk of side effects. Tylenol Extra Strength is primarily used for the treatment of sciatica, muscle pain, general pain, and fever. It may also be used for purposes not listed in its medication guide.

Tylenol Extra Strength Ratings and Reviews

Tylenol Extra Strength has an average rating of 5.9 out of 10 on Drugs.com, based on 30 reviews. 48% of reviewers reported a positive effect, while 34% reported a negative effect.

Key Comparison: Excedrin Extra Strength vs. Tylenol Extra Strength

When comparing Excedrin Extra Strength and Tylenol Extra Strength, the main differences are:

  • Active Ingredients: Excedrin contains acetaminophen, aspirin, and caffeine, while Tylenol contains only acetaminophen.
  • Approved Uses: Excedrin is approved for osteoarthritis, migraines, and general pain/fever, while Tylenol is approved for sciatica, muscle pain, pain, and fever.
  • Ratings and Reviews: Excedrin has a higher average rating of 7.1 out of 10, with 67% of reviewers reporting a positive effect, compared to Tylenol’s average rating of 5.9 out of 10 and 48% of reviewers reporting a positive effect.

Side Effects of Excedrin Extra Strength

Some common side effects of Excedrin Extra Strength include:

  • Stomach pain, heartburn, nausea, vomiting
  • Dizziness, headache
  • Ringing in the ears
  • Allergic reactions

See the full list of Excedrin side effects for more information.

Side Effects of Tylenol Extra Strength

Some common side effects of Tylenol Extra Strength include:

  • Nausea, vomiting
  • Rash
  • Liver damage (with overdose)

See the full list of Tylenol side effects for more information.

Pricing and Availability

Both Excedrin Extra Strength and Tylenol Extra Strength are available over-the-counter and as lower-cost generic versions. Pricing will vary by location and retailer, but Excedrin tends to be slightly more expensive than Tylenol.

Which is Better: Excedrin Extra Strength or Tylenol Extra Strength?

The “better” option between Excedrin Extra Strength and Tylenol Extra Strength will depend on the individual’s specific needs and preferences. Factors to consider include:

  • Intended use (e.g. migraines vs. muscle pain)
  • Sensitivity to the active ingredients
  • Ratings and reviews
  • Cost and availability

It’s always best to consult with a healthcare provider before starting any new over-the-counter medication. They can help determine the most appropriate and safest option based on the individual’s medical history and needs.

Excedrin vs Tylenol Comparison – Drugs.com

Excedrin vs Tylenol Comparison – Drugs.com
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Over-the-counter

Prescribed for Osteoarthritis, Migraine, Pain/Fever. Excedrin may also be used for purposes not listed in this medication guide.

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Prescription and OTC

Tylenol is an effective mild pain reliever with a low risk of side effects. Prescribed for Sciatica, Muscle Pain, Pain, Fever. Tylenol may also be used for purposes not listed in this medication guide.
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More about
Excedrin
(acetaminophen / aspirin / caffeine)

More about
Tylenol
(acetaminophen)

Generic Status

Lower-cost generic is available

Lower-cost generic is available

Ratings & Reviews

Excedrin has an average rating of
7. 1 out of 10 from a total of
39 ratings on Drugs.com.
67% of reviewers reported a positive effect, while 31% reported a negative effect.

Tylenol has an average rating of
5.9 out of 10 from a total of
30 ratings on Drugs.com.
48% of reviewers reported a positive effect, while 34% reported a negative effect.

View all 39 reviews

View all 30 reviews

Drug Class
  • Analgesic combinations
  • Miscellaneous analgesics
Side Effects

See also: Excedrin side effects in more detail.

See also: Tylenol side effects in more detail.

Pricing and Coupons
* Prices are without insurance

We could not find an exact match for this medicine. Try searching the Price Guide directly.

Quantity1000 each
Dosage325 mg
Per Unit*$0.06
Cost*$57.59

View all
Tylenol prices and generic prices

Get free Discount Card

Get free Discount Card

Dosage Form(s) Available
  • Oral tablet
  • Oral tablet
Half Life
The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

10 hours

2.5 hours

CSA Schedule **
View glossary of terms

Is not subject to the Controlled Substances Act.

Is not subject to the Controlled Substances Act.

Pregnancy Category

See the full pregnancy warnings document.

See the full pregnancy warnings document.

Drug Interactions

A total of 463 drugs are known to interact with Excedrin:

  • 60 major drug interactions (199 brand and generic names)
  • 322 moderate drug interactions (1327 brand and generic names)
  • 81 minor drug interactions (373 brand and generic names)

A total of 112 drugs are known to interact with Tylenol:

  • 7 major drug interactions (20 brand and generic names)
  • 70 moderate drug interactions (216 brand and generic names)
  • 35 minor drug interactions (160 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Ask your doctor before using acetaminophen together with alcohol. This can cause serious side…
    View more

  • Ask your doctor before using acetaminophen together with alcohol. This can cause serious side…
    View more

Disease Interactions
  • Alcoholism
  • Liver disease
  • Coagulation
  • Cardiac disease
  • Hypertension
  • Liver disease
  • Psychiatric disorders
  • PUD
  • Asthma
  • GI toxicity
  • Renal dysfunction
  • Reye’s syndrome
  • PKU
  • Cardiotoxicity
  • Bipolar disorders
  • Psychotic disorders
  • Renal dysfunction
  • Seizure disorders
  • GERD
  • Anemia
  • Dialysis
  • G-6-PD deficiency
  • Hepatotoxicity
  • Alcoholism
  • Liver disease
  • PKU
First Approval Date

N/A

June 08, 1994

WADA Class
View World Anti-Doping Agency classifications.

N/A

N/A

More Information
  • Side effects
  • Pregnancy warnings
  • Dosage information
  • Drug interactions
  • Support group
  • Side effects
  • Pregnancy warnings
  • Breastfeeding warnings
  • Dosage information
  • Drug images
  • Drug interactions
  • Support group
  • Pricing and coupons
  • En Español
Patient resources
  • Overview
  • Overview
  • Advanced reading
Professional Resources

N/A

N/A

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Excedrin Migraine vs Tylenol Extra Strength: What is the difference?

79points

Excedrin Migraine

81points

Tylenol Extra Strength

Comparison winner

vs

59 facts in comparison

Excedrin Migraine

Tylenol Extra Strength

Why is Excedrin Migraine better than Tylenol Extra Strength?

  • Is anti-inflammatory?
  • Not linked to constipation?
  • 2 higher daily limit?
    8vs6
  • 250mg more aspirin content?
    250mgvs0mg
  • 65mg more caffeine content?
    65mgvs0mg
  • Not linked to diarrhea?
  • Not linked to loss of appetite?
  • Not linked to easy bruising in case of overdose?

Why is Tylenol Extra Strength better than Excedrin Migraine?

  • Targets toothaches?
  • Targets rheumatic pain?
  • 250mg more paracetamol content?
    500mgvs250mg
  • Targets muscular pain?
  • Can be used to treat cold and flu symptoms?
  • 25 more pills in the box?
    325vs300
  • Not linked to heartburn?
  • Not linked to Reye’s syndrome?

Panadol Advance

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Panadol Extra Advance

Tylenol Arthritis Pain

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Tylenol Extra Strength

Advil

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Nurofen Plus

Excedrin Migraine

vs

Midol Complete Caplets

Aleve Liquid Gels

vs

Aleve Tablets

Excedrin Migraine

vs

Midol Extended Relief

Excedrin Migraine

vs

Tylenol Extra Strength

Tylenol Extra Strength

vs

Tylenol PM

Aleve Caplets

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Excedrin Extra Strength

Midol Complete Caplets

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Tylenol Extra Strength

Composition

ibuprofen

Ibuprofen is a non-steroidal anti-inflammatory. The painkilling effects of ibuprofen take effect immediately, however the anti-inflammatory effects can take as long as a week.

paracetamol

Paracetamol (or acetaminophen as it is known in the US) is classified as a mild analgesic. It suppresses the feeling of pain, but does little to treat the cause.

aspirin

Aspirin can be used as an analgesic, antipyretic and anti-inflammatory.

caffeine

Studies have shown that caffeine can boost the effectiveness of many analgesics, resulting in better, faster acting pain relief.

codeine

Codeine is an opiate used to treat mild to moderate pain. Opiates can alter the mood, sometimes resulting in feelings of euphoria. This can be beneficial for pain relief, however it can become addictive and withdrawal symptoms are common.

Has more than one active ingredient

✔Excedrin Migraine

✖Tylenol Extra Strength

The product contains more than one active ingredient. These combinations usually compliment each other and sometimes one ingredient can improve the effectiveness of the other.

naproxen

Naproxen is an anti-inflammatory which can be used to treat a variety of symptoms of pain.

Effects

Targets toothaches

✖Excedrin Migraine

✔Tylenol Extra Strength

Toothache is pain in and around the teeth and jawbone, often caused by tooth decay.

Is anti-inflammatory

✔Excedrin Migraine

✖Tylenol Extra Strength

Anti- inflammatory drugs are particularly good for things like muscle and joint pain, as they not only block out the pain but also target the cause.

Is antipyretic (fever reducing)

✔Excedrin Migraine

✔Tylenol Extra Strength

Antipyretic medications help to lower the body temperature. This can help to make patients feel better, however it is not always recommended, as the temperature increase can be a natural defense to fight infections.

Targets rheumatic pain

✖Excedrin Migraine

✔Tylenol Extra Strength

Rheumatic pain is pain in the joints and connective tissues, most commonly caused by arthritis.

Targets muscular pain

✖Excedrin Migraine

✔Tylenol Extra Strength

Muscle pain can be caused by exercise or other stresses, as well as infections such as flu.

Targets migraines

✔Excedrin Migraine

✔Tylenol Extra Strength

A migraine is a very severe headache, often accompanied with other sensory signs such as flashing lights, blind spots, tingling and light sensitivity. Migraine sufferers often struggle to find adequate relief.

Not linked to bloating

✖Excedrin Migraine

✖Tylenol Extra Strength

Bloating, usually in the abdomen, is an uncomfortable swollen feeling. It is usually caused by a build-up of fluid or gas.

Not linked to constipation

✔Excedrin Migraine

✖Tylenol Extra Strength

Constipation means having difficulty with regular bowel movements.

No naproxen-associated heart risk

✔Excedrin Migraine

✔Tylenol Extra Strength

Naproxen may increase your risk of heart attack or stroke, especially if you use it for an extended period of time.

Does

Tylenol (acetaminophen) thin the blood? – Drink-Drink

Tylenol is an over-the-counter pain reliever and fever reducer that is the brand name for acetaminophen. This medication is usually used along with other pain relievers such as aspirin, ibuprofen, and naproxen sodium.

While some people take aspirin because of its mild blood-thinning effect, Tylenol does not thin the blood. However, there are still a few important things to know about Tylenol and how it works when choosing between using it and other pain relievers, including blood thinners.

How Tylenol works

Although acetaminophen has been around for over 100 years, scientists are still not 100 percent sure how it works. There are many working theories.

One of the most common is that it blocks certain types of cyclooxygenase enzymes. These enzymes work to create chemical messengers called prostaglandins. Among other tasks, prostaglandins transmit messages that signal pain and lead to fever.

In particular, acetaminophen can stop the formation of prostaglandins in the nervous system. It does not block prostaglandins in most other body tissues. This distinguishes acetaminophen from non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, which also reduce inflammation in tissues.

While this is the most widely accepted theory of how Tylenol works, researchers are also looking into how it can potentially affect other aspects of the central nervous system. This includes receptors such as serotonin and endocannabinoid.

It may seem unusual that doctors don’t know exactly how Tylenol works. However, there are many drugs available on the market today with a similar history that are safe when used as directed.

Tylenol Benefits

Tylenol is largely a safe and effective pain and fever reducer. Because doctors believe that Tylenol mainly affects the central nervous system, it is less likely to irritate the stomach compared to aspirin and ibuprofen.

In addition, Tylenol does not affect the blood and blood clotting, as does aspirin. This makes it safer for people who are already taking blood thinners or who are at risk of bleeding.

Physicians generally recommend Tylenol as the preferred pain reliever during pregnancy. Other pain relievers, such as ibuprofen, are associated with an increased risk of pregnancy complications and birth defects.

Tylenol disadvantages

Tylenol can damage your liver if you take too much.

When you take Tylenol, your body breaks it down into a compound called N-acetyl-p-benzoquinone. Normally, the liver breaks down this compound and releases it. However, if there is too much of it, the liver cannot break it down and this damages the liver tissue.

It is also possible to accidentally take too much acetaminophen. The acetaminophen found in Tylenol is a common addition to many medications. This includes narcotic pain relievers and pain relievers that may contain caffeine or other ingredients.

A person may take the recommended dose of Tylenol and not know that their other medications contain acetaminophen. That’s why it’s important to read medication labels carefully and always tell your doctor about all medications you take.

Also, for those who want a pain reliever that also has blood thinning or anti-inflammatory properties, Tylenol does not offer them.

Tylenol versus blood thinners

Both Tylenol and aspirin are over-the-counter pain relievers. However, unlike Tylenol, aspirin also has some antiplatelet (clotting) properties.

Aspirin blocks the formation of a compound called thromboxane A2 in blood platelets. Platelets are responsible for sticking together to form a clot when you have a cut or wound that bleeds.

Although aspirin does not stop blood from clotting completely (you will still stop bleeding if cut), it does reduce the chance of blood clots. This can be helpful in preventing strokes and heart attacks, which can be caused by blood clots.

There is no drug that can reverse the effects of aspirin. Only time and the creation of new platelets can do that.

It’s important to know that aspirin is also found in some other over-the-counter products, but is not as widely advertised. Examples include Alka-Seltzer and Excedrin. Read medication labels carefully to make sure you don’t accidentally take aspirin in more than one way.

Safety of taking Tylenol with blood thinners

If you are taking blood thinners such as Coumadin, Plavix, or Eliquis, your doctor may recommend taking Tylenol for pain instead of aspirin or ibuprofen. Some people take both aspirin and other blood thinners, but only on the advice of a doctor.

Doctors generally do not recommend taking Tylenol if you have liver problems. This includes cirrhosis of the liver or hepatitis. When the liver is already damaged, the doctor may suggest taking pain medication that does not potentially affect the liver.

Choice of pain medication

Tylenol, NSAIDs and aspirin can be effective pain relievers. However, there may be situations where one pain reliever is better than another.

I am 17 and need pain medication. What should I take?

Avoid taking aspirin as it increases the risk of Reye’s syndrome in people aged 18 years and younger. Tylenol and ibuprofen can be effective and safe when taken as directed.

I have a muscle strain and need pain medication. What should I take?

If you have a muscle injury in addition to pain, taking an NSAID (such as naproxen or ibuprofen) may help reduce the inflammation causing the pain. Tylenol is also good in this case, but it will not relieve inflammation.

I have a history of bleeding ulcers and need pain medication. What should I take?

If you have a history of ulcers, indigestion, or gastrointestinal bleeding, taking Tylenol may reduce your risk of further bleeding compared to aspirin or ibuprofen.

Conclusion

Tylenol can be a safe and effective pain reliever and antipyretic when taken as directed. It does not have a blood-thinning effect like aspirin.

Unless your doctor tells you otherwise, you should only avoid Tylenol if you are allergic to it or if you have a history of liver problems.

Does Tylenol thin the blood? How does it compare to aspirin and others? This medicine is usually used in combination with other pain relievers such as aspirin, ibuprofen, and naproxen sodium.

While some people take aspirin for its mild blood-thinning effect, Tylenol does not thin the blood. However, there are some more important things about Tylenol and how it works when choosing between it and other pain relievers, including blood thinner.

content

How Tylenol works

Although acetaminophen has been around for over 100 years, scientists are still not 100 percent sure how it works. There are many working theories.

One of the most common is that it blocks certain cyclooxygenase enzymes. These enzymes work to create chemical messengers called prostaglandins. Among other tasks, prostaglandins transmit messages that signal pain and lead to fever.

In particular, acetaminophen can stop the production of prostaglandins in the nervous system. It does not block prostaglandins in most other body tissues. Thus, acetaminophen is different from non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, which also relieve tissue inflammation.

While this is the most widely accepted theory of how Tylenol works, researchers are also looking into how it could potentially affect other aspects of the central nervous system. These include receptors such as serotonin and endocannabinoids.

It may seem strange that doctors don’t know exactly how Tylenol works. However, there are many drugs on the market today with a similar history that are safe when used as directed.

Tylenol Benefits

Tylenol is largely safe and effective in reducing pain and fever. Because doctors believe that Tylenol acts primarily on the central nervous system, it is less likely to irritate the stomach compared to aspirin and ibuprofen.

In addition, Tylenol does not affect the blood and blood clotting, as does aspirin. This makes it safer for people who are already drawing blood or who are at risk of bleeding.

Doctors usually recommend Tylenol as a pain reliever during pregnancy. Taking other pain relievers, such as ibuprofen, is associated with a higher risk of pregnancy complications and birth defects.

Tylenol disadvantages

Tylenol can damage your liver if you take too much.

When you take Tylenol, your body breaks down into a compound called N-acetyl-p-benzoquinone. The liver normally breaks down this compound and releases it. However, if there is too much of it, the liver cannot break it down and it damages the liver tissue.

It is also possible to accidentally take too much acetaminophen. The acetaminophen found in Tylenol is a common addition to many medications. These include pain relievers and pain relievers that may contain caffeine or other ingredients.

A person may be taking the recommended dose of Tylenol and not know that other medicines contain acetaminophen. That’s why it’s important to read medication labels carefully and always tell your doctor about all medications you take.

Also, for those who want a pain reliever that also has blood-thinning or anti-inflammatory properties, Tylenol doesn’t offer them.

Tylenol versus blood thinners

Both Tylenol and aspirin are over-the-counter pain relievers. However, unlike Tylenol, aspirin also has some antiplatelet (clotting) properties.

Aspirin blocks the production of a compound called thromboxane A2 in blood platelets. Platelets are responsible for sticking together to form a clot when you have an incision or bleeding wound.

Although aspirin does not prevent complete blood clotting (you will still stop bleeding after an incision, it reduces the chance of blood clotting. This may be helpful in preventing stroke and heart attack, which can result from blood clots.

There are no drugs that can reverse the effects of aspirin. This can only be achieved with time and the creation of new platelets.

It’s important to know that aspirin is also found in some other over-the-counter products, but is not as widely advertised. Examples include Alka-Seltzer and Excedrin. Reading drug labels carefully can ensure you don’t accidentally take aspirin in several ways.

Safety of taking Tylenol with blood thinners

If you are taking blood thinners such as Coumadin, Plavix, or Eliquis, your doctor may recommend Tylenol instead of aspirin or ibuprofen for pain relief. Some take aspirin and other blood thinners, but only on the advice of a doctor.

Doctors generally do not recommend taking Tylenol if you have liver problems. These include cirrhosis or hepatitis. When the liver is already damaged, the doctor may suggest taking pain medication that does not potentially affect the liver.

Choice of pain relief

Tylenol, NSAIDs and aspirin can be effective pain relievers. However, there may be certain scenarios in which one pain reliever is better than another.