Endocrine Glands | Microscope Slides

The endocrine system is composed of glands that synthesize and secrete products, called hormones, directly into the blood rather than through a duct. Hormones are transported throughout the body where they influence only those cells that have receptors for that hormone.

Hormones can be:

• Proteins/peptides (e.g., insulin, growth hormone)
• Lipid derivatives – derived from cholesterol or fatty acids (e.g., steroids, eicosanoids)
• Amino acid derivatives – derived from tyrosine or tryptophan (e.g., epinephrine, melatonin, thyroid hormones)

Hormone effects are described as:

• Endocrine – released into blood and act at long distances
• Paracrine – diffuse a short distance through tissue fluids to nearby cells
• Autocrine – act on the same cell that produced the hormone

Fig 006 Endocrine Glands

Endocrine glands are highly vascular and often contain fenestrated capillaries to facilitate the diffusion of hormones into blood.

Pituitary

The pituitary is often called the “master gland” of the body because it produces hormones that regulate other endocrine glands, as well as, have direct effects on target tissues.

Fig 025 Pituitary Hormones

MH 149 Pituitary

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MH 150a Pituitary

Azan

Thyroid

The thyroid gland produces hormones, triiodothyronine (T3) and thyroxine (T4), that primarily influence the basal metabolic rate and protein synthesis.

MH 151 Thyroid

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Parathyroid

Parathyroid glands secrete parathyroid hormone (PTH) in response to low blood levels of calcium. PTH secretion causes the release of calcium from bones by stimulating osteoclasts, inhibition of osteoblasts, and increased reabsorption of calcium in the kidney.

MH 154 Parathyroid

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Thyroid-Parathyroid-Thymus

This specimen is unusual in that thyroid, parathyroid gland and thymus failed to migrate to their proper locations during development.

MHS 209 Thyroid-Parathyroid-Thymus

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Adrenal Glands

Adrenal glands produce a variety of hormones that help regulate metabolism, blood pressure, response to stress, and other essential functions.

MH 155a Adrenal Gland

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MHS 216 Adrenal Gland

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Pancreatic Islets

Pancreatic islets (or islets of Langerhans) are ‘islands’ of endocrine cells located within the exocrine pancreas. They secrete hormones (insulin and glucagon) important in the regulation of glucose in blood.

MH 131 Pancreas

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MHS 211 Pancreas

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MH 133 Pancreas

Aldehyde Fuchsin

UCSF 295 Pancreas

Gomori’s Stain

What is the Endocrine System

The endocrine system is a system of glands that produce and release hormones into the bloodstream. These hormones control many vital functions in the body, such as growth, metabolism, and reproduction.

What is the endocrine system?

The endocrine system is very complex, and scientists are still learning much about how it works. But we know that the circulatory system is essential in delivering hormones to their target tissues.

The endocrine system includes many different glands. These include the pituitary, thyroid, adrenal, and pancreas. Each gland produces specific hormones that help to regulate various bodily functions. For example, the pituitary gland produces growth hormone, which allows the body to grow and develop. The thyroid gland produces thyroxine, which helps to regulate metabolism. The adrenal gland produces adrenaline, which helps mobilize the body’s resources during stress.

Glands of the Body

There are many different glands in the body, each with a specific function. The endocrine glands produce hormones, which are chemical substances that regulate the body’s growth, metabolism, and reproduction.

Pituitary gland

The pituitary gland is at the base of the brain; this gland produces growth hormone, which regulates body growth. The pituitary gland is also responsible for producing other hormones, such as adrenocorticotropic hormone (ACTH), which controls the production of stress hormones in the adrenal gland. Fight or flight, the system which can make us feel stressed or anxious, is controlled by the pituitary gland.

Hypothalamus

The hypothalamus is located just below the thalamus, near the center of the brain. It produces many hormones, including corticotropin-releasing hormone (CRH), which regulates the production of stress hormones in the adrenal gland. The hypothalamus also regulates body temperature, hunger, thirst, and fatigue.

Thyroid Gland

The thyroid gland is in the front of the neck, just below the voice box (larynx). It produces thyroid hormone, which regulates the body’s metabolism. The thyroid hormone helps the body convert food into energy and plays a role in growth and development.

Parathyroid Gland

The parathyroid gland is in the neck, behind the thyroid gland. It produces parathyroid hormone, which helps to regulate calcium levels in the body. Calcium is essential for many functions, including muscle contraction, nerve function, and blood clotting.

Adrenal Glands

The adrenal glands are on top of the kidneys and produce stress hormones, such as adrenaline and cortisol. These hormones help the body to respond to stressful situations.

Pancreas

The pancreas is in the abdomen, behind the stomach. It produces insulin, a hormone that helps to regulate blood sugar levels. The pancreas also produces other hormones, such as glucagon, which help to regulate metabolism.

Pineal Gland

The pineal gland is in the brain, near the center of the head. It produces melatonin, a hormone that helps to regulate sleep. The pineal gland also helps to regulate the body’s circadian rhythm or internal clock.

Reproductive Glands (Ovaries and Testes)

The ovaries and testes are the primary reproductive glands. The ovaries produce eggs, which are necessary for fertilization. They also produce hormones, such as estrogen and progesterone, which play a role in reproduction.

The testes produce sperm, which is essential for fertilization. They also produce testosterone, a hormone that helps to regulate male characteristics, such as muscle mass and hair growth.

Hormones

Now that we have discussed the body’s glands, let’s talk about hormones. As we mentioned before, hormones are chemical substances that regulate the body’s growth, metabolism, and reproduction. They are produced by the endocrine glands and released into the bloodstream. Hormones travel through the blood to their target tissues, which bind to specific receptors. This binding of the hormones to the receptors triggers a response in the target tissue.

There are many different hormones in the body, each with a specific function. Some of the more important hormones include:

Adrenaline (stress hormone)

Adrenaline increases heart rate, blood pressure, and blood sugar levels which gives the body extra energy to deal with a stressful situation

Cortisol (stress hormone)

Cortisol helps the body to respond to stress by regulating metabolism, blood sugar levels, and immune function.

Estrogen

Estrogen regulates the menstrual cycle and helps to develop female characteristics, such as breasts and hips. Estrogen also protects bone health.

Progesterone

Progesterone prepares the body for pregnancy by thickening the uterus lining and also plays a role in breast milk production.

Testosterone

Testosterone helps to develop male characteristics, such as muscle mass and hair growth; it also regulates sex drive.

Thyroid hormone

The thyroid hormone regulates the body’s metabolism, which is the process of converting food into energy. It also controls nervous system activity.

Insulin

Insulin regulates blood sugar levels by helping the body store and use glucose (sugar). Many other hormones in the body play essential roles in regulating growth, metabolism, and reproduction.

Hormone Imbalances

Hormone imbalance occurs when there is too much or too little of a particular hormone in the body. Hormone imbalances can lead to various health problems, including infertility, obesity, and diabetes.

The are several ways to correct hormone imbalances. One way is to take hormone replacement therapy, which involves taking hormones in pill form. Another way is to have surgery to remove the gland that is not functioning correctly. Finally, some hormone imbalances can be treated with lifestyle changes, such as diet and exercise.

Circulatory System

The circulatory system is essential for the proper functioning of the endocrine system and is responsible for transporting hormones throughout the body. The circulating blood carries hormones to its target tissues, binding to specific receptors. This binding of hormones to the targets triggers a response in the target tissue. Without the circulatory system, hormones would be unable to reach their target tissues and perform their functions.

There are two main types of circulation in the body: The first one is systemic circulation: which transports oxygen-rich blood to the body’s tissues. Pulmonary circulation: transports carbon dioxide-rich blood from the body’s tissues to the lungs.

People Also Ask About Endocrine System

What are hormones?

Hormones are chemical messenger molecules produced by the endocrine glands. These hormones travel through the bloodstream and bind to specific receptors on target cells. This binding triggers a response in the target cells, which can be anything from stimulating cell growth to regulating metabolism.

Hormones are important for many vital functions in the body, including growth, metabolism, and reproduction. Imbalances in hormone levels can lead to a variety of health problems.

What are endocrine disorders?

Endocrine disorders occur when there is an imbalance of hormones in the body. This can be due to a problem with the function of one or more endocrine glands, or it can be due to issues with the hormones themselves. Common endocrine disorders include diabetes, hypothyroidism, and adrenal insufficiency. Treatment for endocrine disorders often involves medication, lifestyle changes, or surgery.

How can I help regulate my hormones?

There are some easy strategies to help you regulate hormone levels, including engaging in physical activity, maintaining a healthy weight, eating a balanced diet with protein, reducing stress with activities such as meditation or yoga, and getting enough sleep.

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ReSources

Anatomy of the Endocrine System | Johns Hopkins Medicine

Endocrine System: What Is It, Functions & Organs

Hormones and the Endocrine System | Johns Hopkins Medicine

Endocrine System: What Is It, Functions, Organs & Conditions

Reproductive Glands – Health Encyclopedia – University of Rochester Medical Center

10 Natural Ways to Balance Your Hormones

Examination of the thyroid gland and endocrine system in Germany

• University medicine
• Specialized centers
• Professor’s consultation
• Cancer diagnostics
• Outpatient diagnostics
• Stationary diagnostics
• Histological examination
• Laboratory diagnostics
• Radiological research methods
• Official conclusion
• Examination results during the day
• Treatment plan
• Ordering medicines
• Cost
• All types of radiological diagnostics: if necessary, CT, MRI, PET-CT, SPECT-CT
• Arrival organization 1-3 days

Remote endocrinologist consultation 100 € – 390 € (depending on the medical institution)

Face-to-face consultation with an endocrinologist 250 € – 500 € (depending on the medical institution)

The endocrine system is very important for the body, as it completely affects the proper functioning of the whole organism. Provides self-regulation of the body with various changes in the external environment, regulates development and growth, takes part in the process of conservation and proper use of energy. The most common diseases of the endocrine system include:

• diseases of the thyroid gland (goiter, inflammatory diseases, hypothyroidism, thyrotoxicosis, Basedow’s disease, cancer, developmental anomalies)
• diabetes mellitus and diabetes insipidus
• hormonal disorders
• diseases and functional disorders of the adrenal glands.

Pathological and functional changes in the functions of the thyroid gland lead to serious changes in the body.

Thyroid examination includes history, examination, ultrasound and, if necessary, thyroid scintigraphy, special blood test, including hormones and antibodies, final consultation, discharge summary, and, if necessary, treatment.

The need for certain examinations in each case is determined by the doctor.

Examination is carried out by the head physician or head of the clinic

Duration : 1-2 days

Examination: outpatient

Examination fee: from 350 €

Violation of the endocrine system – General information, Causes. Novosibirsk

General information

Disorders of the endocrine system are pathological conditions that occur as a result of improper activity of the endocrine glands or endocrine glands that secrete the substances (hormones) produced by them directly into the blood or lymph. Endocrine glands include:

• pituitary;

• thyroid and parathyroid glands;

• adrenal glands and glands with mixed function;

• gonads;

• pancreas.

The main role of endocrine glands in the body is expressed in their influence on the processes of metabolism, growth, physical and sexual development. Violation of the endocrine system leads to the emergence of various disorders of the body. At the heart of endocrine disorders is either an excessive increase or decrease in the functions of a particular gland.

Disorders of the endocrine system

The pituitary gland is considered the center of regulation of the endocrine system, since it produces hormones that specifically stimulate the growth, differentiation and functional activity of some endocrine glands.

Violation of the complex functions of the pituitary gland leads to the development of a number of pituitary disorders: excessive function of the anterior pituitary gland causes acromegaly. Decreased function of the anterior lobe pituitary gland can cause:

Decreased function of the posterior pituitary gland provokes the development of diabetes insipidus . The patient has copious urine output and intense thirst.

An increase in the function of the thyroid gland is manifested in an increase in its volume. The following disorders occur:

With a pronounced increase in the function of the thyroid gland, protrusion of the eyeballs or bulging eyes is observed.

Decreased function of the thyroid gland is accompanied by a decrease in the thyroid gland, slowing of the heartbeat and retraction of the eyeballs. There is a tendency to obesity, constipation, dry skin, a decrease in general excitability, changes in the skin and subcutaneous tissue, which become edematous. This state is called myxedema.

An increase in adrenal gland function is accompanied by premature puberty (most often due to the formation of tumors). A decrease in the function of the adrenal cortex in severe cases gives a picture of Addison’s disease (bronze disease), in which characteristic dark, bronze pigmentation of the skin appears, exhaustion, blood pressure decreases, blood sugar decreases, and the body’s resistance decreases.

Enhancing the function of the medulla I of the adrenal gland causes the development of arterial hypertension in the form of seizures. An increase in the function of the gonads is rarely observed (more often due to the development of malignant tumors of these glands), mostly in childhood. The gonads reach their full development prematurely. A decrease in the function of these glands leads to eunuchoidism, increased growth with disproportionate lengthening of the lower and upper limbs, a tendency to obesity, with the distribution of fat in men according to the female type and underdevelopment of the genital organs, and the absence of a secondary hairline.

Increased pancreatic function not well understood. Individual manifestations are a persistent decrease in blood sugar, a tendency to obesity. A decrease in the function of this gland leads to an increase in blood and urine sugar, an increase in urination, and a decline in nutrition (diabetes mellitus).

Regulation of the endocrine glands

Regulation of the activity of the endocrine glands is carried out in the vegetative nerve centers of the diencephalon through the vegetative-nerve fibers and through the pituitary gland under the control of the cerebral cortex. The nervous and endocrine systems are closely related and constantly interact.

Endocrine glands have a great influence on the growth and development of the body, metabolic processes, excitability and tone of the nervous system. Features of the functioning of individual links of the endocrine system play an important role in the formation of the body in general and its constitutional features in particular.

The natural course of age-related changes in the body can be sharply disturbed under the influence of disorders of internal secretion from one or more endocrine glands.

Causes of endocrine system disorders :

• Primary dysfunction of the peripheral endocrine glands. Various pathological processes can develop in the gland itself and lead to disruption of the formation and secretion of the corresponding hormones.

• Peripheral forms of endocrine disorders. Peripheral endocrine disorders can be caused by impaired binding of hormones to proteins at the stage of their transport to target cells, inactivation or destruction of the circulating hormone, impaired hormone reception and metabolism, and impaired permissive mechanisms.

An important place among the causes of damage to the peripheral endocrine glands is occupied by infections. Some of them (for example, tuberculosis, syphilis) can be localized in different glands, causing their gradual destruction, in other cases there is a certain selectivity of the lesion (for example, meningococcal sepsis is often accompanied by hemorrhage in the adrenal glands, viral parotitis often causes orchitis and testicular atrophy, and orchitis can also occur with gonorrhea).

The cause of damage to the glands and disorders of hormone formation are tumors that can develop in any gland. The nature of endocrine disorders in this case depends on the nature of the tumor. If the tumor originates from secretory cells, excessive amounts of hormones are usually produced and a picture of hyperfunction of the gland occurs.

If the tumor does not secrete the hormone but only compresses and causes atrophy or destroys the gland tissue, its progressive hypofunction develops. Quite often tumors have metastatic character. In some cases tumors of the endocrine glands produce hormones that are not characteristic of this gland, ectopic foci of hormone formation in tumors of non-endocrine organs are also possible.

Disorders of the endocrine system may be due to congenital defects in the development of glands or their atrophy . The latter is caused by various reasons, namely:

• sclerotic process;

• chronic inflammation;

• age involution;

• hormonally active tumor of the paired gland;

• long-term treatment;

• exogenous hormones.

Damage and atrophy of the gland are sometimes based on autoimmune processes (in some forms of diabetes mellitus, diseases of the adrenal glands, thyroid gland).

The formation of hormones is disturbed due to hereditary defects in the enzymes necessary for their synthesis, or inactivation of the enzymes. Some forms of cortico-genital syndrome , endemic cretinism and other endocrine diseases arise in this way. It is also possible to form abnormal forms of hormones in the gland. Such hormones have inferior activity or are completely devoid of it. In some cases, the intraglandular conversion of the prohormone into a hormone is disrupted, and therefore its inactive forms are released into the blood.

Disorders in the biosynthesis of hormones can be caused by a deficiency of specific substrates that make up their composition (for example, iodine, which is necessary for the formation of thyroid hormones).

One of the causes of endocrine disorders is the depletion of hormone biosynthesis as a result of prolonged stimulation of the gland and its hyperfunction. In this way, some forms of insufficiency of beta-cells of the pancreatic islet apparatus, stimulated by prolonged hyperglycemia, occur.

Increased attention is paid to anti-receptor antibodies. It is believed that the mechanisms of production of anti-receptor antibodies may be associated with some features of the immune system itself.

Hormonal disorders

Antibodies may be caused by a viral infection; suggest that in such cases, the virus binds to a hormone receptor on the cell surface and provokes the formation of anti-receptor antibodies. One of the forms of insufficiency of hormonal effects may be associated with a violation of the permissive action of hormones.

Deficiency of cortisol , which has a powerful and versatile permissive effect on catecholamines, sharply weakens the glycogenolytic, lipolytic effects of adrenaline, the pressor effect and some other effects of catecholamines. In the absence of the necessary amounts of thyroid hormones, the action of growth hormone cannot be normally realized in the early stages of the development of the organism.