About all

Difficulty having bowel movement. Constipation in Cancer Patients: Symptoms, Causes, and Treatments

What are the main causes of constipation in cancer patients. How does cancer treatment affect bowel movements. What are effective ways to manage constipation during cancer therapy.

Содержание

Understanding Constipation in Cancer Patients

Constipation is a common issue for individuals with cancer, often arising as a side effect of treatment or due to the disease itself. It’s characterized by difficulty in having bowel movements, which can significantly impact a patient’s quality of life.

What Defines Constipation?

Constipation occurs when passing stools becomes challenging. In cancer patients, this can be due to various factors related to their condition and treatment. It’s important to recognize that normal bowel habits vary from person to person, but generally, constipation involves infrequent bowel movements (typically less than three times a week) or the passage of hard, dry stools that are difficult to expel.

The Physiology of Bowel Movements

To comprehend constipation, it’s crucial to understand how the bowels function normally. The large intestine, or colon, plays a vital role in this process.

How Does the Large Intestine Work?

The large intestine is responsible for absorbing water and nutrients from the food we consume. As digested food moves through the colon, waste matter gradually forms into stool. This waste is then stored in the rectum until it’s ready to be expelled from the body.

Muscles in the bowel assist in pushing the stool into the rectum. Under normal circumstances, when the stool reaches the rectum, it should be formed enough to pass comfortably. However, constipation can occur if too much water is reabsorbed into the body or if the bowel muscles are weak and slow.

Cancer Treatments and Their Impact on Bowel Function

Various cancer treatments can lead to constipation, affecting the normal functioning of the digestive system.

Chemotherapy and Targeted Therapies

Some chemotherapy drugs and targeted cancer therapies can cause constipation by affecting the nerve supply to the gut. This side effect can be exacerbated by certain anti-nausea medications and painkillers commonly prescribed during cancer treatment.

Abdominal Surgery

Surgery to the abdomen can temporarily or permanently weaken bowel muscles, depending on the type of operation. Post-surgical constipation may result from several factors:

  • Weakened muscles making it difficult to expel stool
  • Abdominal soreness hindering the pushing action needed for bowel movements
  • Anesthetics and pain medications causing constipation
  • Reduced food and fluid intake immediately after surgery
  • Potential nerve damage from major pelvic operations affecting bowel function

The Direct Impact of Cancer on Bowel Function

Cancer itself can cause constipation through various mechanisms related to tumor growth and location.

Spinal Cord Compression

Tumors pressing on the nerves in the spinal cord can slow down or halt bowel movements, leading to constipation.

Abdominal Tumors

Tumors in the abdomen may compress, squeeze, or narrow the bowel and rectum, making it challenging to have a bowel movement. Additionally, tumors in the bowel lining can affect the nerve supply to the muscles, causing constipation.

Medications and Their Role in Causing Constipation

Many medications used in cancer treatment and symptom management can contribute to constipation.

Common Culprits in Cancer Care

The most frequent medications causing constipation in cancer patients include:

  1. Opioid painkillers
  2. Anti-nausea medications

Other Medications That May Cause Constipation

Several other drugs can also lead to constipation:

  • Blood pressure medications
  • Antidepressants
  • Vitamin supplements (especially iron and calcium)
  • Anti-epileptic drugs
  • Parkinson’s disease medications
  • Diuretics
  • Some antacids

It’s crucial for patients to inform their healthcare providers about all medications they’re taking, including over-the-counter constipation remedies.

Dietary Factors Contributing to Constipation

Diet plays a significant role in bowel health, and certain dietary habits can contribute to constipation in cancer patients.

Fiber Intake and Its Importance

A diet low in fiber can lead to constipation. Fiber helps keep bowels working regularly by adding bulk to stools and promoting regular bowel movements. However, cancer patients experiencing nausea may find it challenging to consume sufficient fiber-rich foods.

Hydration and Bowel Function

Adequate fluid intake is essential for maintaining soft stools that pass easily through the bowel. Dehydration can lead to harder stools and constipation. Cancer patients may be at risk of dehydration due to treatment side effects or reduced fluid intake.

Lifestyle Factors Affecting Bowel Movements

Certain lifestyle aspects can significantly impact bowel function, especially in cancer patients.

The Role of Physical Activity

Lack of daily exercise can reduce muscle tone in the abdomen and bowel, slowing down the movement of stool through the gut. Regular, gentle exercise can help maintain proper bowel function. However, cancer patients may face challenges in maintaining physical activity due to fatigue or treatment side effects.

Age-Related Changes in Bowel Function

As people age, their bowel function tends to change, often due to reduced activity levels or dietary changes. This puts older individuals, including many cancer patients, at a higher risk of constipation.

Ignoring the Urge to Defecate

Some individuals may find it difficult to have bowel movements outside their homes or may ignore the urge due to busy schedules. Research has shown that regularly ignoring the urge to defecate can increase the risk of constipation.

Diagnostic Approaches for Constipation in Cancer Patients

Proper diagnosis of constipation in cancer patients is crucial for effective management.

Medical History and Physical Examination

Healthcare providers typically start with a detailed medical history and physical examination. They may inquire about bowel habits, medication use, diet, and any recent changes in these areas.

Diagnostic Tests

In some cases, additional tests may be necessary to determine the underlying cause of constipation:

  • Abdominal X-rays to visualize any blockages
  • Colonoscopy to examine the colon for any abnormalities
  • Blood tests to check for metabolic or hormonal imbalances
  • Transit time studies to assess how quickly food moves through the digestive system

Treatment Strategies for Constipation in Cancer Patients

Managing constipation in cancer patients often requires a multi-faceted approach.

Dietary Modifications

Increasing fiber intake through diet or supplements can help improve bowel regularity. Healthcare providers may recommend:

  • Consuming more fruits, vegetables, and whole grains
  • Adding fiber supplements to the diet
  • Increasing fluid intake to soften stools

Lifestyle Changes

Simple lifestyle adjustments can significantly impact bowel function:

  • Engaging in regular, gentle exercise as tolerated
  • Establishing a routine for bowel movements
  • Using relaxation techniques to reduce stress and promote bowel regularity

Pharmacological Interventions

Various medications can be used to manage constipation in cancer patients:

  1. Stool softeners to make bowel movements easier
  2. Stimulant laxatives to increase bowel activity
  3. Osmotic laxatives to draw water into the bowel
  4. Prescription medications for chronic constipation

It’s important to note that the use of these medications should be under the guidance of a healthcare provider, as they may interact with cancer treatments or have side effects.

Preventing Constipation During Cancer Treatment

Prevention is often easier than treatment when it comes to constipation in cancer patients.

Proactive Measures

Healthcare providers may recommend preventive strategies, especially for patients starting treatments known to cause constipation:

  • Prophylactic use of stool softeners or mild laxatives
  • Regular monitoring of bowel habits
  • Early intervention at the first signs of constipation

Patient Education

Educating patients about the importance of maintaining bowel health can be crucial. This may include information on:

  • Recognizing early signs of constipation
  • Understanding the impact of diet and hydration on bowel function
  • Learning techniques for effective bowel movements

Complications of Untreated Constipation in Cancer Patients

If left untreated, constipation can lead to serious complications in cancer patients.

Potential Risks

Complications of severe or chronic constipation may include:

  • Fecal impaction, where hardened stool becomes lodged in the rectum
  • Bowel obstruction, potentially requiring surgical intervention
  • Hemorrhoids or anal fissures from straining
  • Urinary retention or incontinence due to pressure on the bladder

Impact on Quality of Life

Chronic constipation can significantly affect a cancer patient’s quality of life, leading to:

  • Discomfort and pain
  • Reduced appetite and nutritional intake
  • Psychological distress and anxiety
  • Interference with cancer treatment schedules

Special Considerations for Different Cancer Types

Constipation management may vary depending on the type and location of cancer.

Colorectal Cancer

Patients with colorectal cancer may face unique challenges in managing constipation due to the direct involvement of the bowel. Treatment approaches may need to be more cautious and tailored to avoid exacerbating tumor-related symptoms.

Cancers Affecting the Nervous System

Cancers that impact the nervous system, such as brain tumors or spinal cord tumors, may cause neurogenic bowel dysfunction. This requires specialized management strategies that address both the constipation and the underlying neurological issues.

Cancers Requiring Extensive Abdominal Surgery

Patients undergoing major abdominal surgeries for cancers like ovarian or pancreatic cancer may experience prolonged post-operative constipation. Management in these cases often involves a combination of early mobilization, careful pain management, and gradual reintroduction of diet.

The Role of Palliative Care in Managing Constipation

Palliative care plays a crucial role in managing symptoms like constipation, especially in advanced cancer patients.

Holistic Approach

Palliative care teams take a comprehensive approach to constipation management, considering:

  • The patient’s overall comfort and quality of life
  • Balancing constipation management with other symptom control measures
  • Psychological and emotional support for patients dealing with chronic symptoms

End-of-Life Considerations

In end-of-life care, managing constipation remains important for patient comfort. Approaches may include:

  • Simplified medication regimens
  • Non-pharmacological comfort measures
  • Family education on bowel care

Emerging Research and Future Directions

Ongoing research continues to explore new strategies for managing constipation in cancer patients.

Novel Therapies

Emerging treatments for constipation in cancer care include:

  • New classes of medications targeting specific receptors in the gut
  • Probiotic and prebiotic therapies to modulate gut microbiota
  • Advanced non-invasive techniques for stimulating bowel function

Personalized Medicine Approaches

Future management strategies may involve more personalized approaches, considering:

  • Genetic factors influencing drug metabolism and bowel function
  • Individual patient microbiome profiles
  • Tailored dietary and lifestyle interventions based on patient-specific factors

As research progresses, the management of constipation in cancer patients is likely to become more sophisticated and effective, improving quality of life and treatment outcomes for those affected by this common and challenging symptom.

Causes of constipation | Coping physically

Constipation means difficulty having a poo. It can be a problem for people with cancer and during cancer treatment.

The bowels and how they work

To understand what causes constipation, it helps to know how your bowel (large intestine) works.

The large bowel draws water and nutrients into the body from the food you eat and drink. As the digested food passes through the bowel (the colon), the waste matter or stool (poo) gradually forms.

The poo is stored in your rectum, or back passage, until it is ready to pass out of your body as a bowel motion.

The muscles in your bowel help to push the poo into your rectum. When it gets to your rectum the poo is should be formed enough to pass through comfortably.  But you can become constipated if:

  • too much water is drawn back into the body from the bowel
  • the muscles in your bowel are weak and slow

Chronic constipation 

Long term or chronic constipation means difficulty having a poo that can last for several weeks or longer.

Cancer treatments

Some cancer treatments can cause constipation. This includes several chemotherapy drugs and having surgery to your tummy (abdomen). 

Cancer drugs

Some chemotherapy drugs and targeted cancer drugs cause constipation. This is because they can affect the nerve supply to the gut. 

Unfortunately, some anti sickness drugs and painkillers can make this worse.

Surgery to your tummy (abdomen)

After surgery to your bowel, your bowel muscles might be weaker. This may be temporary, but sometimes it can be permanent – this depends on the type of operation you have.

After this type of surgery, there are several factors that can cause constipation:

  • weak muscles may make it more difficult to push the poo out
  • your tummy might be too sore for you to push out the poo
  • the drugs you have as an anaesthetic or for pain can also cause constipation
  • you may not be able to eat or drink for a few days after your operation, which makes constipation more likely
  • occasionally, some major pelvic operations can damage the nerves that help the bowel to work properly

The cancer itself

A tumour that presses on the nerves in your spinal cord can slow down or stop the movement of your bowel. This causes constipation.

Tumours in the tummy (abdomen) can squash, squeeze, or narrow the bowel and back passage (rectum) making it difficult for you to have a bowel motion.

Or a tumour in the lining of the bowel can affect the nerve supply to the muscles and cause constipation.

Side effects from other medicines

Constipation can be a side effect of many types of drugs. Some of these drugs help control cancer symptoms or reduce side effects from treatments.

Your doctor or nurse will also prescribe medicine to help prevent constipation.

The most common drugs to cause constipation in people with cancer are:

  • painkillers, especially morphine based drugs (opioids)
  • anti sickness medicines

Other drugs that can cause constipation are:

  • some blood pressure medicines
  • anti depressants
  • vitamin supplements, such as iron and calcium
  • drugs to stop fits (anti convulsants or anti epileptics)
  • drugs for Parkinson’s disease
  • drugs to make you pass urine (diuretics)
  • some medicines for indigestion (antacids)

It is important to tell your doctor or pharmacist if you are taking over the counter medication for constipation.

Too little fibre in your diet

Fibre helps to keep our bowels working regularly. If you eat plenty of foods high in fibre you’re less likely to become constipated. 

But if you feel sick, you might find it hard to eat enough fibre.

Not drinking enough

Your body needs plenty of fluid to help poo stay soft and pass easily through your bowel. You can become dehydrated and begin to have problems with constipation if you don’t drink enough.

Lack of exercise

Not getting much daily exercise can reduce muscle tone in your tummy (abdomen) and bowel. This slows down the movement of poo through your gut. 

Taking regular gentle exercise will help keep your bowels working properly. 

Age

As we get older, the way our bowels work tends to change. This might be due to being less active or changes to your diet. So there is a higher risk of constipation.

Ignoring the urge to open your bowels

Some people find it difficult to open their bowels away from the comfort of their own home. Others find that a busy lifestyle stops them opening their bowels. 

Research has shown people who ignore the urge to open their bowels are more at risk of constipation. Water is drawn out of the poo as it sits in the rectum and so it gets harder and more difficult to pass. It is always best to listen to your body. Try to go to the toilet when you feel the urge to have a bowel movement. 

Depression and anxiety

People with cancer may suffer from depression and anxiety. These conditions can sometimes lead to constipation.

Nerves link your brain and gut. When you are depressed, these nerves are not as active as usual. This can affect the way the muscles in your bowel work.

Other medical conditions

Many medical conditions, other than cancer, can cause constipation. Some of these include:

  • bowel blockage (obstruction)
  • Parkinson’s disease
  • spinal cord injuries
  • diabetes
  • having too much calcium in your blood (hypercalcaemia)
  • multiple sclerosis
  • thyroid problems
  • having a stroke
  • problems with the structure of the bowel and back passage (rectum)
  • Hirschsprung’s disease – a rare disease that is present from birth and affects the nerves in your bowel
  • high calcium levels in the blood (hypercalcaemia)
  • low levels of potassium in the blood (hypokalaemia)
  • Constipation – Clinical Knowledge Summary 
    National Institute for Health and Care Excellence (NICE), revised March 2021 

  • Diagnosis, assessment and management of constipation in advanced cancer: ESMO Clinical Practice Guidelines

    P. J Larkin and others

    Annals of Oncology, 2018. Vol 29, Supplement 4.

  • Managing Constipation in Adults With Cancer

    Rita J. Wickham

    Journal of Advanced Practioner in Oncology, 2017. Volume 8, Issue 2, Pages 149–161.

  • Constipation: Evaluation and Management

    B Jani, and E Marsicano

    Missouri Medicine 2018. Volume 115, Issue 3, Pages 236–240.

Last reviewed: 

13 Dec 2022

Next review due: 

13 Dec 2025