Amazon Pharmacy: Diflunisal (Oral Tablet)

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Diflunisal Oral Tablet 500 mg

Uses

This medicine is used for the following purposes:

• arthritis
• gout
• pain

Instructions

Swallow the medicine without crushing or chewing it.

Take the medicine with 250 mL (1 cup) of water.

You may take with food to prevent stomach upset.

Store at room temperature in a dry place. Do not keep in the bathroom.

Keep the medicine away from heat and light.

If you forget to take a dose on time, take it as soon as you remember. If it is almost time for the next dose, do not take the missed dose. Return to your normal dosing schedule. Do not take 2 doses of this medicine at one time.

Please tell your doctor and pharmacist about all the medicines you take. Include both prescription and over-the-counter medicines. Also tell them about any vitamins, herbal medicines, or anything else you take for your health.

Cautions

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine. Symptoms of an allergic reaction can include trouble breathing, skin rash, itching, swelling, or severe dizziness.

Some patients with weak hearts may have worsening of symptoms. If you notice difficulty breathing, weight gain, or swelling of your legs or ankles, let your doctor know right away.

Some patients taking this medicine have experienced serious side effects. Please speak with your doctor to understand the risks and benefits associated with this medicine.

This medicine is associated with an increased risk of serious heart problems, heart attack, and stroke. Please speak with your doctor about the risks and benefits of using this medicine. Contact your doctor immediately if you experience chest pain or difficulty breathing.

This medicine may cause serious bleeding from the stomach or bowels. Stop this medicine and call your doctor immediately if you see any signs of bleeding. Bleeding can cause pain in the stomach, vomiting up liquid that looks like coffee grounds, and red or dark tarry stools.

Do not use the medication any more than instructed.

Your ability to stay alert or to react quickly may be impaired by this medicine. Do not drive or operate machinery until you know how this medicine will affect you.

Speak with your doctor before taking any medicine with aspirin.

Please check with your doctor before drinking alcohol while on this medicine.

If you drink more than a few alcoholic beverages each day, ask your doctor whether you should be on this medicine.

Avoid smoking while on this medicine. Smoking may increase your risk for stroke, heart attack, blood clots, high blood pressure, and other diseases of the heart and blood vessels.

Contact your doctor if you notice a change in the amount or darkening of your urine.

Tell the doctor or pharmacist if you are pregnant, planning to be pregnant, or breastfeeding.

This medicine can hurt a new baby in the womb. If you become pregnant while on this medicine, tell your doctor immediately. Your doctor may switch you to a different medicine.

Ask your pharmacist if this medicine can interact with any of your other medicines. Be sure to tell them about all the medicines you take.

Please tell all your doctors and dentists that you are on this medicine before they provide care.

Do not start or stop any other medicines without first speaking to your doctor or pharmacist.

Call your doctor right away if you notice any unusual bleeding or bruising.

Do not share this medicine with anyone who has not been prescribed this medicine.

This medicine can cause serious side effects in some patients. Important information from the U.S. Food and Drug Administration (FDA) is available from your pharmacist. Please review it carefully with your pharmacist to understand the risks associated with this medicine.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

• increased risk of bleeding
• bloating
• dizziness
• drowsiness or sedation
• lack of energy and tiredness
• excess gas
• headaches
• liver problems
• nausea
• stomach upset or abdominal pain

Call your doctor or get medical help right away if you notice any of these more serious side effects:

• unusual bruising or discoloration on skin
• chest pain
• changes in memory, mood, or thinking
• coughing up blood or vomit that looks like coffee grounds
• swelling of the legs, feet, and hands
• fast or irregular heart beats
• symptoms of liver damage (such as yellowing of skin or eyes, dark urine, unusual tiredness or weakness; severe stomach or back pain)
• skin irritation such as redness, itching, rash, or burning
• ringing in the ears
• shortness of breath
• light colored stool
• dark, tarry stool
• difficulty swallowing
• urinating less often
• blurring or changes of vision
• sudden or unexplained weight gain

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.

Extra

Please speak with your doctor, nurse, or pharmacist if you have any questions about this medicine.

https://krames.meducation.com/V2.0/fdbpem/9003

IMPORTANT NOTE: This document tells you briefly how to take your medicine, but it does not tell you all
there is to know about it.Your doctor or pharmacist may give you other documents about your medicine.
Please talk to them if you have any questions.Always follow their advice. There is a more complete
description of this medicine available in English.Scan this code on your smartphone or tablet or use
the web address below. You can also ask your pharmacist for a printout. If you have
any questions, please ask your pharmacist.

© 2021 First Databank, Inc.

tablets for body pain have anti-inflammatory, analgesic and antipyretic effects

The frequency of adverse reactions (AR) is given as the following classification: very often (≥1/10), often (from ≥1/100 to <1/10), uncommon (≥1/1000 to <1/100), rare (≥1/10,000 to <1/1000), very rare (<1/10,000), frequency not known (cannot be estimated based on available data) ).

The most frequently observed adverse reactions were from the gastrointestinal tract. It is possible to develop a peptic ulcer, gastric perforation or gastrointestinal bleeding, sometimes fatal, especially in elderly patients (see section “Special Instructions”).

Within each group, HPs are listed in descending order of severity.

Blood and lymphatic system disorders:

Uncommon: Eosinophilia, granulocytopenia, leukopenia, thrombocytopenia.

Nervous system disorders:

often: headache, vertigo, dizziness, drowsiness;

infrequently: depression, sleep disturbance, impaired concentration, insomnia, malaise.

Visual disturbances:

common: visual impairment.

Hearing and labyrinth disorders:

often : tinnitus, hearing impairment;

Uncommon: hearing loss.

Cardiac disorders:

common: swelling, palpitations;

Uncommon: congestive heart failure.

Respiratory, thoracic and mediastinal disorders:

often : shortness of breath;

infrequently : eosinophilic pneumonia.

Gastrointestinal disorders:

often: constipation, abdominal pain, dyspepsia, nausea, diarrhoea, stomatitis, flatulence;

infrequently: gastrointestinal bleeding and / or gastric perforation, hematemesis, melena, vomiting;

very rare : relapse or worsening of ulcerative colitis or Crohn’s disease;

frequency unknown : gastritis.

Liver and biliary tract disorders:

infrequently: increased activity of “liver” enzymes, jaundice.

Skin and subcutaneous tissue disorders:

often : pruritus, skin rash, ecchymosis, purpura;

infrequently : alopecia, photodermatosis;

very rare : bullous reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis.

Musculoskeletal and connective tissue disorders:

infrequently : myalgia and muscle weakness.

Renal and urinary tract disorders:

Uncommon: glomerulonephritis, hematuria, interstitial nephritis, nephrotic syndrome, renal failure, renal papillary necrosis.

General disorders and administration site disorders:

often : thirst, increased sweating;

infrequently : hypersensitivity reactions, menstrual disorders, hyperthermia (chills and fever).

During therapy with non-steroidal anti-inflammatory drugs, edema and symptoms of heart failure, increased blood pressure were reported.

Clinical studies and epidemiological data suggest that the use of certain non-steroidal anti-inflammatory drugs (especially high doses for long-term therapy) may be associated with a slight increase in the risk of arterial thrombosis (eg, myocardial infarction or stroke).

Undesirable effects, the causal relationship of which has not been established with the use of naproxen

Blood and lymphatic system disorders: aplastic anemia, hemolytic anemia.

Nervous system disorders: aseptic meningitis, cognitive dysfunction.

Skin and subcutaneous tissue disorders: erythema multiforme; photosensitivity reactions like cutaneous porphyria tarda and epidermolysis bullosa; hives.

Vascular disorders: vasculitis.

General disorders and administration site disorders: angioedema, hyperglycemia, hypoglycemia.

If you notice these adverse reactions, stop taking the drug and, if possible, consult a doctor.

Top

The active ingredient is NAPROXENUM | Compendium – drug reference book

• Pharmacological properties
• Indications NAPROXEN
• Application of NAPROXEN
• Contraindications
• Side effects
• Special instructions
• Diagnosis
• Recommended alternatives
• Trade names

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NSAIDs. It has a pronounced anti-inflammatory, analgesic and antipyretic effect due to inhibition of COX and blockade of prostaglandin synthesis. Inhibits platelet aggregation.

Almost completely absorbed in the digestive tract. Around 99% of naproxen binds to plasma proteins. It penetrates slowly into the joint cavity: 3-4 hours after oral administration, the concentration of naproxen in the synovial fluid is 50% of the concentration in the blood plasma, and after 15 hours – about 74%. The full therapeutic effect develops 10 hours after administration. Naproxen is excreted primarily in the urine. T _½ is 12-15 hours. The excretion of naproxen in hepatic and renal insufficiency can be significantly reduced.

rheumatism, rheumatoid arthritis, juvenile arthritis, ankylosing spondylitis, osteoarthritis, gout, pain syndrome of various origins (especially due to inflammation), including post-traumatic and postoperative pain syndrome, headache, toothache, dysmenorrhea. Local treatment: pain in muscles and joints; in degenerative joint diseases.

adults at the beginning of treatment and in acute conditions are prescribed (if well tolerated) higher doses, usually 500-1000 mg / day in 2 divided doses (morning and evening).

Increased doses are used for severe pain, morning stiffness, trauma, and when switching from treatment with other NSAIDs or corticosteroids to naproxen. After achieving clinical improvement, it is prescribed in a maintenance dose – 500 mg / day in 1 or 2 doses with meals. In an acute attack of gout, an initial dose of 750 mg is prescribed – every 8 hours, 250 mg until the symptoms of the disease disappear.

Children over 5 years of age are prescribed at a dose of 10 mg/kg/day in 2 divided doses every 12 hours with meals.

Gel is applied externally. It is recommended to use a strip of gel about 4 cm long, applying it to clean and dry skin 4-5 times a day at intervals of several hours.

After application, spread the gel and rub gently until completely absorbed. The site of application of the gel should not be covered with a bandage or plaster. The duration of treatment depends on the course of the disease, as well as the effectiveness of treatment and, as a rule, is no more than 4 weeks.