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Diverticulitis antibiotics how long to work. Diverticulitis Treatment: Antibiotics, ER Visits, and Recovery Timeline

How long do antibiotics take to work for diverticulitis. When should you go to the ER for diverticulitis symptoms. What are the treatment options and recovery timeline for diverticulitis.

Understanding Diverticulitis: Causes and Symptoms

Diverticulitis is a condition that occurs when small pouches (diverticula) that form in the walls of the colon become inflamed or infected. These pouches, known as diverticulosis, are common in older adults and usually don’t cause problems. However, when they become inflamed, it can lead to diverticulitis, a potentially serious condition.

What are the common symptoms of diverticulitis? The most prevalent signs include:

  • Severe abdominal pain, typically on the lower left side
  • Fever and chills
  • Nausea and vomiting
  • Changes in bowel habits (constipation or diarrhea)
  • Bloating and gas

Is diverticulitis easily confused with other conditions? Yes, it can be mistaken for several other gastrointestinal issues, including:

  • Appendicitis
  • Irritable Bowel Syndrome (IBS)
  • Colon cancer
  • Urinary Tract Infection (UTI)
  • Pelvic inflammatory disease (PID)

Due to the similarity in symptoms with other conditions, it’s crucial to seek medical attention for proper diagnosis and treatment.

When to Seek Emergency Care for Diverticulitis

While mild cases of diverticulitis can often be managed at home, certain symptoms warrant immediate medical attention. When should you go to the emergency room for diverticulitis? Here are three critical signs that indicate you need to seek emergency care:

  1. Excessive vomiting and severe nausea
  2. Fever of more than 100 degrees Fahrenheit, with or without chills
  3. Loss or sudden change in appetite

Why is prompt medical attention important for severe diverticulitis? Delaying treatment can lead to serious complications, including:

  • Abscess formation
  • Perforation of the colon
  • Peritonitis (inflammation of the abdominal lining)
  • Fistula formation
  • Intestinal obstruction

These complications can be life-threatening if not addressed quickly, which is why it’s crucial to err on the side of caution and seek emergency care when experiencing severe symptoms.

Diagnosis and Treatment Options for Diverticulitis

How is diverticulitis diagnosed? When you visit the emergency room or your doctor’s office with symptoms of diverticulitis, several diagnostic tests may be performed:

  • Blood tests to check for infection and inflammation
  • CT scan of the abdomen and pelvis
  • Abdominal ultrasound
  • X-rays of the abdomen

Once diagnosed, what are the treatment options for diverticulitis? The approach to treatment depends on the severity of the condition:

Mild to Moderate Cases:

  • Oral antibiotics (typically for 7-10 days)
  • Clear liquid diet for a few days, gradually introducing low-fiber foods
  • Rest and pain management

Severe Cases:

  • Hospitalization
  • Intravenous antibiotics
  • Bowel rest (no food by mouth)
  • Possible surgical intervention

In rare cases where complications arise or conservative treatments fail, surgery may be necessary. Surgical options can include:

  • Primary bowel resection
  • Bowel resection with colostomy

It’s important to discuss the benefits and risks of each treatment option with your healthcare provider to determine the best course of action for your specific situation.

Antibiotic Treatment for Diverticulitis: Efficacy and Timeline

Antibiotics play a crucial role in treating diverticulitis by combating the infection and reducing inflammation. How long do antibiotics typically take to work for diverticulitis?

Most patients start to experience relief from symptoms within 24 to 48 hours after beginning antibiotic treatment. However, it’s essential to complete the full course of antibiotics as prescribed by your doctor, which usually lasts 7 to 10 days.

Which antibiotics are commonly prescribed for diverticulitis? The most frequently used antibiotics include:

  • Ciprofloxacin and metronidazole
  • Amoxicillin-clavulanate
  • Trimethoprim-sulfamethoxazole

Are there any side effects associated with antibiotic treatment for diverticulitis? While antibiotics are generally safe and effective, some patients may experience side effects such as:

  • Nausea and vomiting
  • Diarrhea
  • Abdominal pain
  • Yeast infections

If you experience severe side effects or your symptoms worsen despite antibiotic treatment, it’s important to contact your healthcare provider promptly.

Recovery and Lifestyle Changes After Diverticulitis

What is the typical recovery time for diverticulitis? The recovery period can vary depending on the severity of the condition and the chosen treatment approach:

  • Mild cases treated with oral antibiotics: 1-2 weeks
  • Severe cases requiring hospitalization: 2-3 weeks or longer
  • Cases requiring surgery: 4-6 weeks or more

To promote healing and prevent future episodes of diverticulitis, what lifestyle changes are recommended?

  1. Gradually introduce a high-fiber diet
  2. Stay well-hydrated
  3. Exercise regularly
  4. Maintain a healthy weight
  5. Quit smoking
  6. Limit red meat consumption
  7. Avoid NSAIDs when possible

Which foods should be incorporated into a diet for diverticulitis prevention?

  • Cooked vegetables (e.g., carrots, broccoli, spinach)
  • Cooked fruits (e.g., applesauce, baked apples)
  • Whole grains (e.g., brown rice, whole wheat pasta)
  • Legumes (e.g., lentils, black beans)
  • Probiotic-rich foods (e.g., yogurt, kefir, sauerkraut)

By adopting these lifestyle changes and following your doctor’s recommendations, you can significantly reduce the risk of recurring diverticulitis episodes and improve your overall digestive health.

Complications and Long-Term Outlook for Diverticulitis Patients

While many cases of diverticulitis resolve with proper treatment, some patients may experience complications or recurring episodes. What are the potential complications of diverticulitis?

  • Abscess formation
  • Peritonitis
  • Fistula development
  • Intestinal obstruction
  • Bleeding

How often do diverticulitis episodes recur? Studies suggest that approximately 20-30% of patients who have had one episode of diverticulitis will experience a recurrence within 5 years.

Can diverticulitis lead to long-term health issues? While most patients recover fully, some may experience ongoing symptoms or develop chronic complications, such as:

  • Irritable Bowel Syndrome (IBS)-like symptoms
  • Chronic abdominal pain
  • Altered bowel habits
  • Increased risk of colon cancer (in cases of chronic inflammation)

To minimize the risk of complications and recurrences, it’s crucial to follow your doctor’s advice, maintain a healthy lifestyle, and attend regular check-ups.

New Guidelines and Emerging Treatments for Diverticulitis

How have treatment approaches for diverticulitis evolved in recent years? The American Gastroenterological Association (AGA) has released updated guidelines that suggest a more conservative approach to managing uncomplicated, non-severe cases of diverticulitis.

What are the key changes in these new guidelines?

  • Reduced use of antibiotics for mild cases
  • Less emphasis on surgical intervention
  • Increased focus on lifestyle modifications and dietary changes
  • Individualized treatment plans based on patient factors and disease severity

Are there any promising new treatments on the horizon for diverticulitis? Researchers are exploring several innovative approaches, including:

  1. Probiotics and prebiotics to promote gut health
  2. Anti-inflammatory agents to reduce colon inflammation
  3. Minimally invasive surgical techniques for complicated cases
  4. Fecal microbiota transplantation to restore gut flora balance

While these emerging treatments show promise, more research is needed to establish their effectiveness and safety in treating diverticulitis. As always, it’s essential to consult with your healthcare provider to determine the most appropriate treatment plan for your individual case.

Prevention Strategies and Risk Factors for Diverticulitis

Understanding the risk factors and implementing prevention strategies can significantly reduce the likelihood of developing diverticulitis. What are the primary risk factors for this condition?

  • Age (more common in people over 40)
  • Low-fiber diet
  • Obesity
  • Sedentary lifestyle
  • Smoking
  • Regular use of NSAIDs
  • Genetic predisposition

How can you reduce your risk of developing diverticulitis? Implementing the following prevention strategies can be beneficial:

  1. Increase fiber intake: Aim for 25-30 grams of fiber per day
  2. Stay hydrated: Drink at least 8 glasses of water daily
  3. Exercise regularly: Engage in moderate physical activity for at least 30 minutes a day
  4. Maintain a healthy weight: Achieve and maintain a BMI within the normal range
  5. Quit smoking: Seek support to quit if you currently smoke
  6. Limit red meat consumption: Opt for lean proteins and plant-based alternatives
  7. Manage stress: Practice stress-reduction techniques like meditation or yoga

Are there any specific dietary recommendations for preventing diverticulitis? While the old advice to avoid seeds and nuts has been largely debunked, focusing on a high-fiber diet is crucial. Include the following foods in your diet:

  • Whole grains (e.g., oatmeal, quinoa, brown rice)
  • Fresh fruits and vegetables (with the skin, when possible)
  • Legumes (e.g., lentils, chickpeas, black beans)
  • Nuts and seeds in moderation
  • Probiotic-rich foods (e.g., yogurt, kefir, kimchi)

By incorporating these prevention strategies into your daily routine and being aware of the risk factors, you can significantly reduce your chances of developing diverticulitis and promote overall digestive health.

When to Go to the ER for Diverticulitis

When you’re experiencing symptoms caused by some unknown condition, you may instantly begin to panic. What’s causing the discomfort? Can you afford to get treatment? And, should you seek medical attention immediately or can you wait? It may take time — and a doctor’s visit — to answer some of the millions of questions swirling in your head. But, if you’re experiencing symptoms of diverticulitis, your answers may come sooner than you expect. That’s because some signs of the condition shouldn’t be ignored — and require an immediate emergency room visit.

What is diverticulitis?

To explain diverticulitis, you must first understand about diverticulosis. This is the medical term used when a person develops pockets within the walls of their large intestine (also known as the colon). These pockets occur when the interior lining of the colon pushes against the weakest parts of the outer layers. If these pockets become inflamed, the condition is known as diverticulitis. This condition causes extreme pain in the abdomen and can be potentially deadly if not treated promptly and properly. Diverticulitis can also be dangerous because it shares common symptoms with other conditions — including:

  • Appendicitis
  • Irritable Bowel Syndrome (IBS)
  • Colon cancer
  • Urinary Tract Infection (UTI)
  • Pelvic inflammatory disease (PID)

3 Symptoms That Indicate You Should Go to the ER

Nobody wants to go to the emergency room, but sometimes neglecting signs of a problem can have deadly consequences. That’s why you should go to an emergency room immediately if you have any of the following symptoms:

  • Excessive vomiting and severe nausea
  • Fever of more than 100 degrees — with or without chills
  • Loss or sudden change in appetite

An emergency room will identify if any complications could prevent treatment or increase your risk of side effects — including death. In rare cases, a hole within your colon can form, which will need to be treated in addition to diverticulitis.

How to Treat Diverticulitis

During your trip to the emergency room, your doctor will administer a blood test to identify any infections. They may also conduct other tests to help diagnose diverticulitis — including CT scans, ultrasounds of the abdomen, and x-rays of the abdomen.

In most cases, diverticulitis can be treated at home with oral antibiotics, but if your condition is severe, a hospital stay may be required. Your doctor will recommend getting plenty of rest, taking medication to control pain, and drinking mainly fluids for the first couple of days of your recovery. After the first few days, you should introduce a high-fiber diet into your daily routine to ensure your bowels move regularly. You should incorporate foods such as:

  • Cooked vegetables
  • Cooked fruits
  • Apples
  • Foods rich with probiotics

If your condition is extremely severe or other treatments have failed, your doctor may suggest surgery. There are many surgery options, so they’ll be able to provide the most information about which choice is best for your condition. You should talk to your doctor about the benefits and risks before making any decisions.

Diverticulitis Recovery Time

If your condition is being treated with antibiotics, you must take them fully and as directed by your doctor. This can take as long as two weeks. But, you’ll begin to feel better in as short as 24-hours.

If you experience any complications or must receive surgery, your recovery time will take longer. After surgery, you’ll be able to return to normal activities within one to two weeks. You’ll also be required to make follow-up appointments to make sure that recovery is going well and that no infection has occurred. Infection can increase the time it takes to recover. How quickly you recover completely depends on many factors, including:

  • The health of your colon
  • Your age
  • Your general health

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New Guidelines Inform Diverticulitis Treatment

Treatment moves toward less use of antibiotics, less emphasis on surgery

Innovations in Digestive Health | Winter 2021

Colonic diverticulitis remains a painful, unpredictable gastrointestinal disease that can lead to serious complications, chronic symptoms and poor quality of life. While complicated cases require aggressive treatment, recent American Gastroenterological Association (AGA) guidelines suggest a more conservative approach for uncomplicated, nonsevere diverticulitis. Guidelines from the American Society of Colon and Rectal Surgeons (ASCRS) echo AGA’s recommendations.

 Trevor Teetor, MD

In light of these updated guidelines, University Hospitals Digestive Disease Institute has modified its approach to ensure patients receive the most up-to-date, comprehensive care possible. “The AGA guidelines reinforce the need for personalized care,” says Trevor Teetor, MD, colorectal surgeon and assistant professor of Colon and Rectal Surgery at Case Western Reserve University School of Medicine. “They will influence my prescribing style and approach to surgery.”

One notable change: AGA recommends selective, rather than routine, antibiotic use in immunocompetent patients with mild disease. “While antibiotics have long been first-line therapy for acute uncomplicated diverticulitis, recent evidence suggests there is no benefit in immunocompetent patients with mild acute uncomplicated diverticulitis,” the report states.

“We always thought acute cases involved an immediate infection,” Dr. Teetor says. “Now we understand it involves inflammation, which does not necessarily need antibiotics.

AGA does, however, advise antibiotic treatment for patients with comorbidities, who present with concerning, high-risk symptoms or who present with complicated diverticulitis.

 Caption: Pus in the inflamed segment of bowel is typical of diverticulitis.

 Caption: “Pouches” that form in the colon wall is typical of diverticulosis. 

A CONSERVATIVE APPROACH TO SURGERY

Guidelines around surgery have also changed. Surgeons should advise elective segmental resection on a case-by-case basis rather than on a specific number of episodes. Factors to consider include disease severity, patient preferences and values, and the benefits and risks. Chronic gastrointestinal symptoms may not improve with surgery.

The report states that at five-year follow up, patients with recurrent diverticulitis experienced improved quality of life after elective resection. However, 15 percent of patients experienced recurrent diverticulitis after surgery, and between 22 and 25 percent had ongoing abdominal pain.

POST-EPISODE COLONOSCOPY

Because the risk of malignancy is low, AGA recommends colonoscopy on a case-by-case basis. Colonoscopy is advised after complicated diverticulitis and after an initial episode. For recurrent, uncomplicated cases, AGA recommends physicians consider the patient’s history, disease severity and whether they’ve received a high-quality colonoscopy in the past year.

AGA also recommends waiting at least six to eight weeks after an acute episode. Screening before the episode has fully resolved increases risk of perforation, discomfort and can create a more technically demanding procedure for the clinician.

Many different pathologies can mimic diverticulitis symptoms, including ischemic colitis, inflammatory bowel disease and visceral hypersensitivity. The AGA recommends CT scan as the best imaging modality to assess for the presence and severity of diverticular disease.

“There seems to be a general consensus that uncomplicated diverticulitis has been historically overtreated,  we now have a better understanding of the disease process and a greater focus on inflammation rather than infection. The patient must always be managed as a whole with specific factors taken into account, but trends point toward less use of antibiotics, less emphasis on surgery, all of which brings improved patient outcomes.”

-Trevor Teetor, MD

PREVENTATIVE CARE

While a nutritious diet is a cornerstone of good health for everyone, patients with a history of diverticulitis should be especially mindful of their eating habits.

During the acute phase of uncomplicated diverticulitis, “bowel rest” through a clear liquid diet is advised with a goal of patient comfort. If a patient cannot advance their diet after three to five days, a follow-up appointment should be scheduled immediately.

When returning to solid foods, a vegetarian diet and a simple, high-fiber diet rich in fruits, vegetables, legumes and whole grains are associated with decreased diverticulitis risk. And despite myths, corn, popcorn, berry and nut consumption do not increase risk.

To further reduce risk, physicians should encourage patients to participate in vigorous exercise, stop smoking, maintain a healthy weight (obesity increases risk) and watch alcohol consumption. While drinking alcohol generally is not a risk factor, alcoholism does increase risk. Regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) and opiate analgesics should also be avoided, the report states.

Currently there is no medication available to prevent recurrence of diverticulitis. Although multiple studies have examined rifaximin, probiotics, and 5-aminosalicylic acid (mesalamine) on diverticulitis recurrences, both AGA and ASCRS found insufficient evidence to support their use.

“There seems to be a general consensus that uncomplicated diverticulitis has been historically overtreated,” Dr. Teetor says. “We now have a better understanding of the disease process and a greater focus on inflammation rather than infection. The patient must always be managed as a whole with specific factors taken into account, but trends point toward less use of antibiotics, less emphasis on surgery, all of which brings improved patient outcomes.”

For physician consultation or To refer a patient with suspected diverticulitis, call 216-553-1976.

Reference

Peery AF, Shaukat A, Strate LL, AGA Clinical Practice Update on Medical Management of Colonic Diverticulitis: Expert Review, Gastroenterology (2021), doi: https://doi.org/10.1053/j.gastro.2020.09.059.

Antibiotic therapy for diverticulitis . ABC of antibiotic therapy. Vidal medicines guide

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The materials are intended exclusively for doctors and specialists with higher medical education. Articles are informational and educational in nature. Self-medication and self-diagnosis are extremely dangerous for health. The author of the articles does not give medical advice: a clinical pharmacologist is a doctor only and exclusively for doctors.

Pathogens

  • Polymicrobial gastrointestinal flora
  • Anaerobes, including Bacteroides spp
  • Gram-negative rods, including Enterobacteriaceae
  • Enterococci (the pathogenic role of enterococci remains controversial)

Clinical

  • The incidence of diverticulitis increases with age: 50% of people in the population over 60 have diverticula and 10-25% develop clinical diverticulitis
  • Although diverticulitis is an uncommon condition in young people (those younger than 40 years), such cases occur and are often associated with a more severe, complicated course of the disease than in the older age group
  • A sedentary lifestyle and a diet low in fiber are among the main factors in the development of diverticula and diverticulitis
  • Initial symptoms include: left lower quadrant pain, which may or may not be permanent, fever, and colonic dysfunction (constipation or diarrhea)
  • Uncomplicated diverticulitis usually localized in the sigmoid colon, mild, without severe symptoms or associated complications
  • Complicated diverticulitis may be accompanied by the following complications: abscess formation, perforation, fistula formation, or obstruction.
  • Differential diagnosis must be made between: inflammatory bowel disease, ischemic colitis, appendicitis, infectious colitis, pelvic inflammatory disease, pyelonephritis, colon cancer

Diagnosis

  • Objective findings: fever, localized tenderness in the left iliac region +/– symptoms of peritoneal irritation, sometimes abdominal distention may be observed
  • In rare cases, when the sigmoid colon is involved in the process, pain can be localized in the right iliac region and copy the symptoms of acute appendicitis
  • In the case of complicated diverticulitis and intestinal stricture, constipation may develop
  • Laboratory diagnostics: in the general blood test – leukocytosis with a shift to the left
  • Clinical symptoms are usually sufficient to establish a diagnosis. CT can be used in patients with atypical localization of the process or severe/complicated course of the disease (in the absence of a response to ongoing antibiotic therapy or if an abscess or perforation is suspected)
  • CT is the most preferred examination method. Her criteria include visualization of a sigmoid diverticulum, bowel wall thickening, increased soft tissue density in pericolic adipose tissue secondary to inflammation, and soft tissue mass suggestive of cellulitis or abscess
  • CT sensitivity is 90-95%, but specificity is less than 72%
  • Ultrasound, barium x-ray, and endoscopy can only be used in a very limited number of patients due to the possibility of perforation in the acute period

Treatment

Inpatient care

  • Administration of intravenous antibiotic therapy, intestinal unloading, +/- total parenteral nutrition or nasogastric tube feeding
  • The drugs of choice are: ticarcillin/clavulanate 3.1 g IV every 6 hours (for community-acquired/moderate disease) or piperacillin/tazobactam 3.375 g IV or 4.5 g IV every 8 hours (for nosocomial and severe course)
  • Third or fourth generation cephalosporins or fluoroquinolones or aztreonam plus metronidazole (moxifloxacin has FDA approval for use in intra-abdominal infections as monotherapy, but likely moderate infections)
  • Cefoxitin 1-2 g IV every 6 hours (moderate course)
  • Ertapenem 1 g IV every 24 hours (for patients at high risk of resistant pathogens, consider imipenem-cilastine 500 mg IV every 6 hours or meropenem 1 g IV every 8 hours, or doripenem 500 mg IV every 8 hours)
  • Tigecycline 100 mg loading dose then 50 mg IV every 12 hours (moderate infection) , including intra-abdominal infections.
    Official explanations were later sent out by the manufacturer stating that “Food and Drug Administration ( FDA), no association of deaths with tigecycline has been confirmed. The reasons for the increase in overall mortality in patients treated with tigecycline have not been established.
  • The average duration of therapy is 5-10 days or more, usually antibiotic therapy can be stopped with the onset of clinical improvement: the absence of fever, a decrease in the level of leukocytes, restoration of bowel function, improvement in well-being.
    Transfer to oral therapy is also possible if necessary (see below).

Outpatient care

  • Prescription of oral antibiotics (see below), low fiber diet most needed in the first 2-3 days
  • Amoxicillin/clavulanate 500 mg po 3 times a day or 875 mg po bid
  • Ciprofloxacin 500 mg orally twice a day or levofloxacin 500 mg orally once a day plus metronidazole 500 mg orally every 6 hours
  • Moxifloxacin 400 mg orally every 24 hours (+/- metronidazole 500 mg orally every 6 hours)
  • Trimethoprim/Sulfamctoxazole DS BID plus Metronidazole 500 mg po q 6 hours
  • The average duration of therapy is 5-10 or more days, usually the abolition of antibiotic therapy is carried out when clinical improvement occurs: restoration of bowel function, improvement in well-being, decrease in leukocytosis

Surgical treatment

  • Uncomplicated diverticulitis usually does not require surgical treatment, and vice versa – complicated diverticulitis is an indication for surgical treatment.
  • If an abscess develops as a complication of diverticulitis, percutaneous drainage of the abscess is recommended, which can be used as a watchful management in patients with a localized perforative process without generalization or severe course; resection of the perforated area can be performed later
  • Resection may be required in cases of perforation with generalized peritonitis and/or development of pneumoperitoneum
  • Relapse after the first case is 20-30%, after the second – 30-50%. Resection may be recommended on a case-by-case basis after the 2nd or 3rd episode of exacerbation of diverticulitis
  • A high risk of perforation is typical for immunocompromised patients and patients after surgery

Conclusion

  • Patients with recurrent complicated diverticulitis, fistulas or abscesses, as well as young patients and immunocompromised patients require surgical treatment
  • A diet high in fiber (fruits, vegetables, etc. ) may reduce the risk of colonic diverticula
  • The presence of a diverticulum without signs of diverticulitis is not a reason to prescribe antibiotic therapy
  • Patients with severe disease not responding to oral therapy or at high risk of complications (immunosuppressive, elderly patients, patients with comorbidities) should be hospitalized
  • The presence of diverticula or diverticulitis does not increase the risk of polyps or bowel cancer

Additional information

Rafferty J, Shellito P, Hyman NH at al. Practice parameters for sigmoid diverticulitis. Dis Colon Rectum. 2006 Jul;49(7):939-44. http://www.utcolorectal.org/lib/file/manager/Diverticulitis_DCR_2007.pdf

K57 – Diverticular bowel disease

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Antibiotics for uncomplicated diverticulitis | Cochrane

Cochrane Evidence Synthesis and Methods ►

Diverticulitis is a condition associated with inflammation of so-called diverticula. A diverticulum is a protrusion of the intestinal wall. Diverticula are common in the general population, especially in people over 60 years of age, and are often asymptomatic. Diverticulitis can present with pain and tenderness in the abdomen, accompanied by signs of infection such as fever. In most cases, diverticulitis resolves without complications, but some patients develop complications and may require emergency surgery.

The focus of this review is uncomplicated acute diverticulitis. Traditionally, it was treated as an infection with bacterial overgrowth in the colon and treated with antibiotics. Recently, it has been argued that diverticulitis is more likely to be an inflammatory disease than an infectious disease, making the use of antibiotics questionable. Therefore, there is a shift towards the use of therapeutic regimens without antibiotics. This review considers whether there is any clinical evidence to support the use of antibiotics in uncomplicated diverticulitis.

Five clinical trials involving hospitalized patients were evaluated. One trial looked at two different courses of antibiotic treatment, and a second study looked at the duration of intravenous antibiotic treatment. Three trials examined actual need for antibiotics versus no antibiotics, of which two trials published long-term follow-up results as separate records. None of the studies found statistically significant differences in the studied antibiotic regimens. Comparison of treatment without antibiotics and treatment with antibiotics did not show any difference in the occurrence of complications, such as abscesses and perforations of the colon, or in the need for emergency surgery.

Antibiotics can cause serious adverse effects, including life-threatening allergic reactions or intestinal superinfections. Rising antibiotic resistance is becoming a growing problem, making it difficult to treat some infections and increasing the risk of death. Thus, there are strong arguments for limiting the current use of antibiotics.