About all

Dmso cream side effects. DMSO Side Effects: Understanding Dimethyl Sulfoxide Risks and Benefits

What are the potential side effects of DMSO cream. How does dimethyl sulfoxide work in the human body. What medical conditions can DMSO potentially treat. Is DMSO safe for topical use. What precautions should be taken when using DMSO.

Содержание

What is DMSO and How Does it Work?

Dimethyl sulfoxide (DMSO) is a colorless chemical solvent originally discovered as a byproduct of paper manufacturing in late 19th century Germany. Its unique ability to penetrate biological membranes and transport small molecules through the skin caught the attention of scientists in the 1960s.

DMSO works by easily absorbing into the skin and other tissues. This allows it to potentially deliver medications directly to affected areas when used topically. Its penetrating properties also enable it to potentially reduce inflammation and pain when applied to sore muscles and joints.

Key Properties of DMSO:

  • Colorless liquid solvent
  • Able to penetrate skin and biological membranes
  • Can transport small molecules through skin
  • Absorbs rapidly into tissues
  • May have anti-inflammatory and analgesic effects

FDA-Approved Uses of DMSO

Currently, the only FDA-approved use for DMSO is in treating interstitial cystitis, a chronic bladder condition. It is approved under the brand name RIMSO-50 as a bladder instillation treatment.

For interstitial cystitis patients, DMSO has been shown to:

  • Reduce pain associated with the condition
  • Help relax the bladder
  • Increase bladder capacity

How effective is DMSO for treating interstitial cystitis? Clinical studies have found that about 50-70% of patients experience significant symptom improvement with DMSO bladder instillations. However, effects can vary between individuals.

Potential Off-Label Uses and Benefits of DMSO

While only approved for interstitial cystitis, DMSO has been studied for several other potential medical uses:

Pain and Inflammation

DMSO is often used off-label as an alternative treatment for reducing inflammation and pain. Its ability to penetrate tissues may make it an effective topical analgesic. However, more research is needed to confirm its efficacy for pain relief.

Arthritis

Some studies have examined DMSO as a potential treatment for arthritis symptoms. A review in the Journal of Clinical Rheumatology found that DMSO may help reduce pain and inflammation in osteoarthritis when applied topically. However, evidence is still limited.

Cancer Treatment

Can DMSO play a role in cancer treatment? Early research has shown some promising results. A 2020 study in the Journal of Medical Discovery found evidence that DMSO may help inhibit certain cancer cells. However, this research is still in very early stages.

Chemotherapy Side Effects

DMSO has been investigated for its potential to reduce chemotherapy-related side effects. Some studies suggest it may help decrease tissue damage from chemotherapy drugs. However, more clinical trials are needed to prove its effectiveness and safety for this use.

Common Side Effects of DMSO

While many reported side effects of DMSO are mild, their severity often correlates with the dosage used. Common side effects may include:

  • Garlic-like taste and breath odor
  • Skin irritation at application site
  • Headache
  • Nausea
  • Dizziness
  • Drowsiness

What causes the characteristic garlic odor associated with DMSO use? This occurs because DMSO breaks down into dimethyl sulfide, which produces a garlic-like smell that can be noticed on the breath and skin.

Potential Risks and Severe Side Effects

While less common, more severe side effects of DMSO can occur, especially with higher doses or prolonged use:

  • Severe headache
  • Vomiting
  • Stomach pain
  • Diarrhea
  • Fever and chills
  • Lowered heart rate
  • Itching or rash
  • Skin thickening or roughening

Is DMSO safe for long-term use? The long-term safety of DMSO, especially for off-label uses, has not been thoroughly established. Prolonged use may increase the risk of side effects and should be monitored by a healthcare professional.

Drug Interactions and Precautions

DMSO can potentially interact with certain medications, increasing their effects. This could lead to serious reactions in some individuals. Medications that may interact with DMSO include:

  • Sedatives
  • Blood thinners
  • Steroids

Why does DMSO interact with these medications? DMSO’s ability to enhance absorption and penetration of other substances can increase the potency of these drugs when used concurrently.

Important Precautions:

  1. Always consult a healthcare professional before using DMSO, especially if you’re taking other medications.
  2. Avoid using DMSO products from unverified sources, as purity and concentration can vary.
  3. Do not use DMSO internally without medical supervision.
  4. Discontinue use and seek medical attention if you experience severe side effects.

Administration and Dosage of DMSO

DMSO can be administered in several ways, depending on its intended use:

  • Topically: As a gel or solution applied to the skin
  • Bladder instillation: Via catheter for interstitial cystitis treatment

How should DMSO be applied topically? For topical use, a thin layer of DMSO gel or solution is typically applied to the affected area. It’s important to use only as directed and avoid applying to large areas of skin.

The dosage of DMSO is crucial, as it directly relates to the potential for side effects. Higher concentrations and larger amounts increase the risk of adverse reactions. Always follow the recommendations of a healthcare provider or the product instructions carefully.

Research and Future Potential of DMSO

Despite being discovered over a century ago, research into DMSO’s potential medical uses is ongoing. Current areas of investigation include:

Neuroprotection

Some studies are exploring DMSO’s potential neuroprotective effects. A review in the journal Neurochemical Research suggested that DMSO may help protect nerve cells from damage in certain conditions. However, more research is needed to confirm these effects in humans.

Wound Healing

DMSO’s anti-inflammatory properties have led researchers to investigate its potential in wound healing. Early studies show promise, but clinical trials are still needed to establish its efficacy and safety for this use.

Drug Delivery

Given its ability to penetrate tissues, DMSO is being studied as a potential vehicle for drug delivery. This could allow for more targeted treatment of certain conditions, potentially reducing systemic side effects of medications.

What challenges exist in DMSO research? The main hurdles include the need for more large-scale clinical trials, concerns about long-term safety, and the need to standardize DMSO formulations for medical use.

Legal Status and Availability of DMSO

The legal status and availability of DMSO can vary depending on the country and intended use:

  • In the US, DMSO is FDA-approved only for interstitial cystitis treatment
  • It’s available as a prescription medication for this use
  • DMSO is also sold as an industrial solvent and for veterinary use
  • Some countries allow over-the-counter sales of DMSO for topical use

Can you buy DMSO without a prescription? While DMSO is available for purchase online and in some stores, it’s important to note that these products are not regulated for medical use. Using them without professional guidance can be risky.

Regulatory Challenges

The regulation of DMSO presents several challenges:

  1. Balancing potential benefits with known risks
  2. Ensuring product quality and purity
  3. Preventing misuse or overuse of unregulated products
  4. Funding and conducting necessary clinical trials for potential new uses

How might future research impact DMSO regulation? As more studies are conducted, regulatory bodies may reconsider DMSO’s status for certain medical uses. However, this process is typically slow and requires substantial evidence of both efficacy and safety.

Alternative Treatments and Comparisons

For many of the conditions DMSO is used to treat, there are alternative treatments available. It’s important to consider these options and discuss them with a healthcare provider:

For Pain and Inflammation:

  • Over-the-counter pain relievers (NSAIDs, acetaminophen)
  • Prescription pain medications
  • Physical therapy
  • Acupuncture

For Interstitial Cystitis:

  • Oral medications (pentosan polysulfate sodium, antihistamines)
  • Lifestyle changes
  • Dietary modifications
  • Pelvic floor therapy

How does DMSO compare to these alternatives? The effectiveness can vary depending on the individual and the specific condition. While DMSO may offer benefits in some cases, it’s not always the most effective or safest option.

It’s crucial to work with a healthcare provider to determine the best treatment approach for your specific situation. They can help weigh the potential benefits and risks of DMSO against other available treatments.

Patient Experiences and Anecdotal Evidence

While scientific studies provide crucial information about DMSO’s effects, patient experiences can also offer valuable insights:

Positive Experiences:

  • Some patients report significant pain relief from topical DMSO use
  • Interstitial cystitis patients often note improved symptoms with DMSO treatment
  • Some individuals claim DMSO helps with arthritis pain and stiffness

Negative Experiences:

  • Complaints about the strong garlic-like odor
  • Reports of skin irritation or burning sensation
  • Some users experience headaches or nausea

Why do patient experiences with DMSO vary so widely? Individual responses to DMSO can differ due to factors like dosage, application method, underlying condition, and personal physiology. What works well for one person may not be effective or may cause side effects in another.

It’s important to note that anecdotal evidence, while interesting, should not replace scientific studies or professional medical advice. Always consult with a healthcare provider before trying DMSO or any new treatment.

DMSO in Veterinary Medicine

While this article focuses on human use, it’s worth noting that DMSO is more widely used in veterinary medicine:

  • Commonly used for treating musculoskeletal issues in horses
  • Applied topically for inflammation and swelling in various animals
  • Used as a vehicle for other medications in veterinary treatments

Why is DMSO more commonly used in animals than humans? The regulatory requirements for veterinary medicines are often less stringent than for human drugs. Additionally, the long history of use in animals has provided more data on its effects in veterinary applications.

However, many of the same precautions apply to veterinary use of DMSO. Pet owners should always consult with a veterinarian before using DMSO on their animals.

The Future of DMSO in Medicine

As research continues, the future of DMSO in medicine remains a topic of interest and debate:

Potential Developments:

  • New formulations or delivery methods to reduce side effects
  • Expanded FDA-approved uses if clinical trials show positive results
  • Integration with other therapies for enhanced treatment outcomes
  • Better understanding of long-term effects and optimal dosing

What challenges must be overcome for DMSO to gain wider acceptance in medicine? Key hurdles include conducting large-scale clinical trials, addressing safety concerns, standardizing formulations, and navigating regulatory processes.

Despite these challenges, DMSO’s unique properties continue to intrigue researchers and clinicians. As our understanding of its mechanisms and effects grows, DMSO may find new applications in both conventional and alternative medicine.

In conclusion, while DMSO shows promise in several areas of medicine, its use should always be approached with caution and under professional guidance. As with any medical treatment, the potential benefits must be carefully weighed against the risks. Future research will likely provide more clarity on the role of DMSO in healthcare, potentially opening new avenues for its use while also better defining its limitations and safety profile.

Uses, Benefits, Risks, and More

DMSO (Dimethyl Sulfoxide): Uses, Benefits, Risks, and More

  • Health Conditions
    • Featured
      • Breast Cancer
      • IBD
      • Migraine
      • Multiple Sclerosis (MS)
      • Rheumatoid Arthritis
      • Type 2 Diabetes
    • Articles
      • Acid Reflux
      • ADHD
      • Allergies
      • Alzheimer’s & Dementia
      • Bipolar Disorder
      • Cancer
      • Crohn’s Disease
      • Chronic Pain
      • Cold & Flu
      • COPD
      • Depression
      • Fibromyalgia
      • Heart Disease
      • High Cholesterol
      • HIV
      • Hypertension
      • IPF
      • Osteoarthritis
      • Psoriasis
      • Skin Disorders and Care
      • STDs
  • Discover
    • Wellness Topics
      • Nutrition
      • Fitness
      • Skin Care
      • Sexual Health
      • Women’s Health
      • Mental Well-Being
      • Sleep
    • Product Reviews
      • Vitamins & Supplements
      • Sleep
      • Mental Health
      • Nutrition
      • At-Home Testing
      • CBD
      • Men’s Health
    • Original Series
      • Fresh Food Fast
      • Diagnosis Diaries
      • You’re Not Alone
      • Present Tense
    • Video Series
      • Youth in Focus
      • Healthy Harvest
      • No More Silence
      • Future of Health
  • Plan
    • Health Challenges
      • Mindful Eating
      • Sugar Savvy
      • Move Your Body
      • Gut Health
      • Mood Foods
      • Align Your Spine
    • Find Care
      • Primary Care
      • Mental Health
      • OB-GYN
      • Dermatologists
      • Neurologists
      • Cardiologists
      • Orthopedists
    • Lifestyle Quizzes
      • Weight Management
      • Am I Depressed? A Quiz for Teens
      • Are You a Workaholic?
      • How Well Do You Sleep?
    • Tools & Resources
      • Health News
      • Find a Diet
      • Find Healthy Snacks
      • Drugs A-Z
      • Health A-Z
  • Connect
      • Breast Cancer
      • Inflammatory Bowel Disease
      • Psoriatic Arthritis
      • Migraine
      • Multiple Sclerosis
      • Psoriasis

Medically reviewed by Angelica Balingit, MD — By Jessica DiGiacinto and Joe Bowman — Updated on May 16, 2023

DMSO is a colorless chemical solvent that may have many medical uses but is currently only approved by the FDA to treat interstitial cystitis.

The story of dimethyl sulfoxide (DMSO) is an unusual one. This by-product of the paper making process was discovered in Germany in the late 19th century. It’s a colorless liquid that gained notoriety for its ability to penetrate the skin and other biological membranes.

Scientists discovered that they could use DMSO as a transportation device to pass small molecules through skin in the 1960s. Since then, scientists have researched the potential benefits and risks of using DMSO to treat a variety of conditions. This research is ongoing.

DMSO was approved by the Food and Drug Administration (FDA)to treat interstitial cystitis (a chronic bladder issue) under the brand name RIMSO-50.

The compound has no other approved uses, but it’s been purported to be a treatment for:

  • arthritis
  • cancer
  • chemotherapy side effects
  • general pain

Because it absorbs easily into the skin, it’s also been studied as a vehicle for administering topical drugs.

In the late 70s, the FDA approved DMSO to help treat interstitial cystitis. It remains the only FDA-approved bladder installation (or bladder wash) for this condition. For individuals living with interstitial cystitis, DMSO has been shown to:

  • ease pain due to the condition
  • help relax the bladder
  • increase bladder capacity

When it comes to off-label uses, DMSO is often employed as an alternative treatment to reduce inflammation and pain.

Because it absorbs easily into the skin, DMSO may be a beneficial alternative to other pain medications. However, further investigation into this area is needed before any conclusions can be drawn.

DMSO has also been touted for its ability to reduce the amount of leakage during chemotherapy administration, but more studies, and real-world usage, need to be done before it can be labeled as a trusted method.

Additionally, there has been some research into DMSO’s benefits when it comes to inhibiting cancer cells. A 2020 study published in the Journal of Medical Discovery found evidence of benefit. However, research is just beginning in this area, so many more studies need to be done before any conclusions can be made.

While many of the reported side effects of taking DMSO are mild, the amount of DMSO someone takes is directly correlated to the severity of the reaction.

One common side effect is the taste of garlic in the mouth and throat.

More severe side effects include:

  • headache
  • nausea
  • vomiting
  • stomach ache
  • diarrhea
  • fever
  • chills
  • a lowered heart rate
  • itching
  • rash
  • rough or thickened skin

Risks

Because it’s seen as a more alternative treatment, DMSO is easy to find and buy online. However, buying this product and using it without a healthcare professional’s supervision could increase the likelihood of overuse.

DMSO may also increase the effect of a few medications, which could produce serious reactions in some people. A few medications DMSO may affect include:

  • sedatives
  • blood thinners
  • steroids

DMSO can be administered

  • topically, via a gel or solution
  • as a bladder wash, via a catheter (for interstitial cystitis)

As with any alternative treatment, it’s always advised to talk with a doctor before deciding to purchase any product that contains DMSO. Dosage is directly connected to the severity of possible side effects.

Dimethyl sulfoxide (DMSO) is a chemical solvent that is sometimes used to help reduce inflammation and pain, and may also be beneficial in reducing leakage during chemotherapy treatment.

It has been FDA approved to treat only one condition: interstitial cystitis.

Because of possible interactions with other common medications, and lack of definitive research into its benefits, DMSO should not be used without medical supervision.

Last medically reviewed on February 1, 2022

How we reviewed this article:

Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

  • Capriotti K, et al. (2012). Dimethyl sulfoxide: History, chemistry, and clinical
    utility in dermatology.
    ncbi.nlm.nih.gov/pmc/articles/PMC3460663/
  • Dimethylsulfoxide. (2020).
    mskcc.org/cancer-care/integrative-medicine/herbs/dimethylsulfoxide
  • DMSO. (2009).
    ichelp.org/wp-content/uploads/2015/06/DMSO-Feb-2009.pdf
  • Elisia I, et al. (2016). DMSO represses inflammatory cytokine production from human blood cells and reduces autoimmune arthritis.
    ncbi.nlm.nih.gov/pmc/articles/PMC4816398/
  • Madsen BK, et al. (2018). Adverse reactions of dimethyl sulfoxide in humans: A systematic review.
    ncbi.nlm.nih.gov/pmc/articles/PMC6707402/
  • Molecule of the week archive: Dimethyl sulfoxide. (2021).
    acs.org/content/acs/en/molecule-of-the-week/archive/d/dimethyl-sulfoxide.html?cid=home_motw
  • Tang H, et al. (2020). DMSO inhibits growth and induces apoptosis through extrinsic pathway in human cancer cells.
    https://www.proquest.com/openview/06527232a660b6867effa2ff8f68deed/1?pq-origsite=gscholar&cbl=2050635
  • Understanding unapproved use of approved drugs “off-label.” (2018).
    fda.gov/patients/learn-about-expanded-access-and-other-treatment-options/understanding-unapproved-use-approved-drugs-label
  • Wengström Y, et al. (2008). European oncology nursing society extravasation guidelines.
    sciencedirect.com/science/article/abs/pii/S1462388908001002
  • What is interstitial cystitis(IC)/bladder pain syndrome? (n.d.).
    urologyhealth.org/urology-a-z/i/interstitial-cystitis

Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.

Current Version

May 16, 2023

Written By

Jessica DiGiacinto, Joe Bowman

Edited By

Jessica DiGiacinto

Copy Edited By

Delores Smith-Johnson

Feb 1, 2022

Medically Reviewed By

Angelica Balingit, MD

VIEW ALL HISTORY

Share this article

Medically reviewed by Angelica Balingit, MD — By Jessica DiGiacinto and Joe Bowman — Updated on May 16, 2023

Read this next

  • What Is Cystitis?

    Medically reviewed by University of Illinois

    Cystitis is inflammation of the bladder. Most often it is caused by a bacterial infection known as a urinary tract infection (UTI).

    READ MORE

  • What Are the Symptoms of Interstitial Cystitis?

    Medically reviewed by University of Illinois

    READ MORE

  • Interstitial Cystitis

    Medically reviewed by Carissa Stephens, R.N., CCRN, CPN

    Interstitial cystitis is a chronic inflammation of the bladder that can cause pelvic pain, frequent urination, and incontinence. Pain can be mild or…

    READ MORE

  • Lime and Sun Don’t Always Mix: Beware the ‘Margarita Burn’ This Summer

    Margarita burn is a skin reaction that occurs when lime juice makes contact with the skin and is exposed to sunlight. Most reactions from margarita…

    READ MORE

  • What Is Panniculitis and How Is It Treated?

    Panniculitis is a group of conditions that cause painful bumps (nodules) to form under your skin, often on your legs and feet. Learn more.

    READ MORE

  • Urticaria Pigmentosa

    Medically reviewed by Cynthia Cobb, DNP, APRN, WHNP-BC, FAANP

    Urticaria pigmentosa is a skin condition that causes lesions and itchy skin. This disease is most common in infants and children, but adults may be…

    READ MORE

  • What Causes Dark Knuckles and How Can You Treat Them?

    Medically reviewed by Shilpa Amin, M.D., CAQ, FAAFP

    Dark knuckles can be caused by different skin conditions, medical conditions, genetics, and more. Learn more about the causes, treatments, and natural…

    READ MORE

  • Sunburned Eyelids: What You Should Know

    Medically reviewed by Cynthia Cobb, DNP, APRN, WHNP-BC, FAANP

    You don’t need to be on the beach for sunburned eyelids to occur. Any time you’re outside in the sun for a prolonged period of time with your skin…

    READ MORE

  • Sun Poisoning

    Medically reviewed by Catherine Hannan, M.D.

    Sun poisoning refers to a case of severe sunburn. It occurs after you’ve been exposed to ultraviolet (UV) rays from the sun for an extended period of…

    READ MORE

DMSO – Health Information Library

Uses

DMSO (dimethyl sulfoxide) is a colorless, slightly oily liquid that is primarily used as an industrial solvent.

What Are Star Ratings?

Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.

For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.

3 Stars
Reliable and relatively consistent scientific data showing a substantial health benefit.

2 Stars
Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.

1 Star
For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.

This supplement has been used in connection with the following health conditions:

Used forWhy

3 Stars

Tendinitis

Apply a 10% gel twice per day under medical supervision

Dimethyl sulfoxide is anti-inflammatory and may be applied topically to reduce pain and swelling.

, or dimethyl sulfoxide, has a long history as a topical anti-inflammatory agent. One double-blind trial used a 10% DMSO gel topically on patients with tendinitis of the elbow and shoulder and found that it significantly reduced pain and inflammation in each joint. Other preliminary and double-blind trials found DMSO to be effective in treating tendinitis, but one double-blind trial found no difference between the effects of a 70% DMSO solution and a 5% DMSO placebo solution. Certain precautions must be taken when applying DMSO, and it should only be used under the guidance of a qualified healthcare professional.

2 Stars

Osteoarthritis

Apply a gel containing 25% DMSO under the direction of a qualified healthcare practitioner

Topical DMSO appears to be anti-inflammatory and able to relieve pain associated with osteoarthritis, possibly by inhibiting the transmission of pain messages by nerves.

The therapeutic use of (dimethyl sulfoxide) is controversial because of safety concerns, but some preliminary research shows that diluted preparations of DMSO, applied directly to the skin, are anti-inflammatory and alleviate pain, including pain associated with osteoarthritis. A recent double-blind trial found that a 25% concentration of DMSO in gel form relieved osteoarthritis pain significantly better than a placebo after three weeks. DMSO appears to reduce pain by inhibiting the transmission of pain messages by nerves rather than through a process of healing damaged joints. DMSO comes in different strengths and different degrees of purity; in addition, certain precautions must be taken when applying DMSO. For these reasons, DMSO should be used only with the supervision of a doctor.

2 Stars

Rheumatoid Arthritis

Consult a qualified healthcare practitioner

When applied to the skin, DMSO has anti-inflammatory properties and alleviates pain, apparently by inhibiting the transmission of pain messages by nerves.

The use of dimethyl sulfoxide () for therapeutic applications is controversial in part because some claims made by advocates appear to extend beyond current scientific evidence, and in part because topical use greatly increases the absorption of any substance that happens to be on the skin, including molecules that are toxic to the body. Nonetheless, there is some preliminary evidence that when applied to the skin, it has anti-inflammatory properties and alleviates pain, such as that associated with RA. DMSO appears to reduce pain by inhibiting the transmission of pain messages by nerves. It comes in different strengths and degrees of purity, and certain precautions must be taken when applying DMSO. For these reasons, DMSO should be used only under the supervision of a doctor.

1 Star

Dupuytren’s Contracture

Refer to label instructions

Supplemental dimethyl sulfoxide applied to the affected area may reduce pain by inhibiting transmission of pain messages, and may also soften the connective tissue.

applied to the affected area may reduce pain by inhibiting transmission of pain messages, and may also soften the abnormal connective tissue associated with disorders such as Dupuytren’s contracture, keloids, Peyronie’s disease, and scleroderma. Research on the use of topical DMSO to treat Dupuytren’s contracture remains preliminary and unproven.

1 Star

Peptic Ulcer

Refer to label instructions

DMSO is believed to have antioxidant activity and was found in one study to reduce relapse rates better than the ulcer drug cimetidine (Tagamet).

Oral supplementation with dimethyl sulfoxide () reduced relapse rates for peptic ulcer significantly better than did placebo or the ulcer drug cimetidine (Tagamet) in one study. Previous research showed that DMSO in combination with cimetidine was more effective than cimetidine alone. These trials used 500 mg of DMSO taken four times per day. The authors of these trials believe the antioxidant activity of DMSO may have a protective effect. Oral supplementation with DMSO should not be attempted without the supervision of a doctor.

1 Star

Reflex Sympathetic Dystrophy

Refer to label instructions

1 Star

Scleroderma

Refer to label instructions

1 Star

Sprains and Strains

Refer to label instructions

DMSO has anti-inflammatory properties and may inhibit the transmission of pain messages by nerves. Supplementing with it may ease the pain of minor injuries.

The use of , a colorless, oily liquid primarily used as an industrial solvent, for therapeutic applications is controversial. However, some evidence indicates that dilutions, when applied directly to the skin, have anti-inflammatory properties and inhibit the transmission of pain messages by nerves, and in this way might ease the pain of minor injuries such as sprains and strains. However no controlled research exists to confirm these effects in sprains and strains. DMSO comes in different strengths and different degrees of purity. In addition, certain precautions must be taken when applying DMSO. For those reasons, DMSO should be used only with the supervision of a doctor.

How It Works

How to Use It

DMSO is not indicated for healthy people. Those who do use this substance should consult a doctor familiar with its use. Some physicians do not recommend the use of DMSO due to concerns about safety and questions about efficacy. The potential for contamination exists in some DMSO products designed for industrial uses. DMSO used topically is rapidly absorbed through intact skin. Therefore, the area of skin (and the hands applying DMSO) must be clean, because anything on the skin will also be absorbed along with the DMSO.

Where to Find It

DMSO is derived from trees as a manufacturing by-product from the processing of paper. Metabolites (breakdown products) of DMSO, such as the sulfide and sulfone forms, are naturally present in the human body. However, the role of these in the body is not clear.

Possible Deficiencies

DMSO is not an essential nutrient and it is not needed in the functions of a healthy body; therefore, deficiencies do not exist.

Interactions

Interactions with Supplements, Foods, & Other Compounds

At the time of writing, there were no well-known supplement or food interactions with this supplement.

Interactions with Medicines

As of the last update, we found no reported interactions between this supplement and medicines. It is possible that unknown interactions exist. If you take medication, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.

The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a supplement with your doctor or pharmacist.

Side Effects

Side Effects

DMSO frequently causes a garlic-like body odor and taste in the mouth. Other reported side effects include stomach upset, sensitivity to light, visual disturbances, and headache. Skin irritation can develop at the site where DMSO is applied topically. Only highly purified, properly diluted DMSO should be used and the skin site and applying hand should be thoroughly cleaned before application, because the solvent properties of DMSO allow contaminants to be absorbed through the skin and transported into the bloodstream. Improperly diluted DMSO can also burn the skin. Check with a healthcare professional for appropriate use.

  • Top of the page
  • Next Section:

    How It Works

 

Health Information Library

What helps, active substance, contraindications

Publication date: 06/15/2023

THERE ARE CONTRAINDICATIONS. POSSIBLE SIDE EFFECTS. A SPECIALIST’S CONSULTATION IS NECESSARY.Pain in the jointsPain in the joints and musclesInflammation of the jointsFor joints and ligaments

3 All authors

Article content

  • Dolobene: composition
  • Dolobene: contraindications
  • Dolobene or Heparin ointment: which is better?
  • Dolobene or Diclofenac: which is better?
  • Dolobene or Voltaren: which is better?
  • Dolgit or Dolobene: which is better?
  • Dolobene or Fastum gel: which is better?
  • Dolobene or Traumeel: which is better?
  • Summary
  • Ask an expert on the topic of the article

I wonder if there is a person on earth who has escaped such an injury as a bruise? We think not. ..

Bruises are characterized by mechanical damage without breaking the integrity of the skin. They are accompanied by pain, swelling and bruising. All these symptoms occur due to vascular damage and activation of the inflammation process. As a rule, bruises are not dangerous and pass at home in a week. But in case of an injury to the head or internal organs, it is imperative to see a doctor.

At home, Dolobene helps to cope with the consequences of bruises. The pharmacist talks about its composition and contraindications and compares it with other means: Heparin ointment, Diclofenac, Voltaren, Dolgit, Fastum gel and Traumeel.

Dolobene: Composition

Dolobene is a multicomponent gel for external use. The composition of Dolobene includes not one active ingredient, but three:

  • Sodium heparin has anti-inflammatory, regenerating and antithrombotic effects.
  • Dexpanthenol – in the skin turns into vitamin B5 (pantothenic acid) and improves the processes of regeneration and repair of damaged tissues.
  • Dimethyl sulfoxide 90% solution (DMSO) – has a local analgesic, decongestant and anti-inflammatory effect. It penetrates well through the skin, mucous membranes, improves microcirculation in tissues and increases the permeability of biological membranes for drugs.

The assortment of modern pharmacies has taught visitors that the same medicine can be in different dosage forms. But the drug Dolobene gel is available in only one form, you should not look for ointment, cream or tablets in Dolobene pharmacies.

All products Dolobene

5 reviews

Dolobene: contraindications

Dolobene should not be used during pregnancy, as there are no studies on the use of the drug in such patients. In addition, the gel is contraindicated in the following cases:

  • hypersensitivity to drug components;
  • open skin lesions;
  • severe diseases of the liver and kidneys;
  • serious diseases of the heart and blood vessels;
  • bronchial asthma;
  • children under 5 years of age;
  • lactation.

Dolobene or Heparin ointment: which is better?

Heparin ointment also contains three active ingredients: sodium heparin, benzocaine, benzyl nicotinate. The common component with Dolobene in the ointment is only Heparin sodium.

Dolobene – what helps? Gel is prescribed for bruises, closed injuries and inflammation of soft tissues, tendons and joints. Dolobene helps with bruises, swelling and pain in acute neuralgia.

Heparin ointment has different indications due to a different composition. The ointment is used for inflammatory diseases of the veins (thrombophlebitis, periphlebitis, phlebitis after injections, hemorrhoids), as well as for superficial mastitis, infiltrates, edema, injuries and bruises.

Dolobene contains 500 IU/g of heparin and Heparin Ointment contains 100 IU/g. According to the instructions in the RLS, the penetration of heparin through healthy skin is dose-dependent and has been confirmed for doses of 300 IU/g. The effectiveness of heparin in Doloben is higher due to the dosage and content of the “conductor” DMSO in the gel composition.

Heparin ointment has its own advantages: it has a pronounced analgesic effect due to the local anesthetic benzocaine. In addition, it can be used for bruises and bruises in children older than 1 year, unlike Dolobene, which is used only after 5 years.

Dolobene or Diclofenac: which is better?

Diclofenac is the “gold standard” of non-steroidal anti-inflammatory drugs (NSAIDs). The active substance of the same name comes in various forms for external use: gel, ointment, cream, transdermal patch. Diclofenac has a strong anti-inflammatory effect, so it is prescribed for diseases of the spine and joints, as well as to relieve pain and inflammation due to sprains, bruises and injuries.

The drugs act differently, for example, Dolobene will not help with osteochondrosis, it has an insufficient anti-inflammatory and analgesic effect. But swelling and hematoma after a bruise will pass with it faster than with Diclofenac ointment or gel.

All products Diclofenac

20 reviews

Dolobene or Voltaren: which is better?

Voltaren is an original drug with the active ingredient diclofenac. The above information about Diclofenac is fully applicable to it: Voltaren topical agents relieve inflammation and pain well, and Dolobene improves microcirculation, relieves swelling, dissolves blood clots and promotes tissue repair.

Voltaren topical preparations can only be used in children from 12 years of age. For pregnant women, they can be prescribed by a doctor only up to the 20th week of pregnancy.

All products Voltaren Emulgel

21 reviews

Dolgit or Dolobene: which is better?

Dolgit contains another non-steroidal anti-inflammatory drug, ibuprofen. Dolgit is available in the form of a gel and cream. The drug is approved for use in children from 14 years of age, pregnant women are prescribed only Dolgit gel in the I and II trimester according to indications and under the supervision of a doctor, the cream is contraindicated throughout pregnancy.

The property of ibuprofen to reduce pain and inflammation is used to treat arthritis, osteoarthritis, sciatica, etc. Like Dolobene, Dolgit relieves pain after injuries and bruises. But it does not affect the restoration of tissues and the improvement of blood circulation in the damaged area.

All products Dolgit

20 reviews

Dolobene or Fastum gel: which is better?

The next representative of NSAIDs for the treatment of pain and inflammation is Fastum gel with the active ingredient ketoprofen. Like Dolobene, it has one dosage form in the form of a gel for external use.

Ketoprofen has the most powerful analgesic effect among NSAIDs, so it is used for severe pain as a result of injuries, including bruises, sprains and muscles, as well as for lumbago and rheumatic pains. The gel is contraindicated in pregnancy in the third trimester and in children under 12 years of age.

Fastum causes photosensitivity. When using it, you should protect the skin from the sun during treatment and for another two weeks after it. With mild or moderate pain, bruising and swelling, it is better to use Dolobene.

All products Fastum gel

20 reviews

Dolobene or Traumeel: which is better?

Traumeel S is a homeopathic remedy. Active substances are 12 vegetable and 2 mineral components. Their combination acts in synergy and has an anti-inflammatory and analgesic effect.

Traumeel S is available as an ointment and is approved for use by adults and children from 3 years of age. The ointment eliminates swelling, pain and inflammation in case of damage to muscles, tendons, ligaments; after operations; with bruises, sprains, dislocations.

The ointment can be used in pregnant women if the expected benefit to the mother outweighs the potential risk to the fetus and child. Contraindications for Traumeel S are autoimmune diseases and tuberculosis.

Traumeel S ointment and Dolobene gel are available without a doctor’s prescription. The patient can consult a pharmacy or his doctor and purchase one of the drugs based on his preferences.

All products Traumeel

20 reviews

Summary

  • Dolobene is a multicomponent gel for external use. It contains sodium heparin, dexpanthenol and dimethyl sulfoxide. The gel is prescribed for bruises, closed injuries and inflammation of soft tissues, tendons and joints. Dolobene helps with bruises, swelling and pain in acute neuralgia.
  • Dolobene should not be used during pregnancy, as there are no studies on the use of the drug in such patients.
  • Heparin ointment also contains three active ingredients: sodium heparin, benzocaine, benzyl nicotinate. The ointment is used for inflammatory diseases of the veins (thrombophlebitis, periphlebitis, phlebitis after injections, hemorrhoids), as well as for superficial mastitis, infiltrates, edema, injuries and bruises.
  • Voltaren with Diclofenac, as representatives of NSAIDs, act differently. For example, Dolobene will not help with osteochondrosis, it has an insufficient anti-inflammatory and analgesic effect. But swelling and hematoma after a bruise will pass with it faster than with an ointment or gel with diclofenac.
  • Dolgit relieves pain after injuries and bruises. But it does not affect the restoration of tissues and the improvement of blood circulation in the damaged area.
  • Ketoprofen has the most powerful analgesic effect among NSAIDs, so it is used for severe pain as a result of trauma, including bruises, sprains and muscles, as well as for lumbago and rheumatic pains.
  • Traumeel S is a homeopathic remedy. The ointment eliminates swelling, pain and inflammation in case of damage to muscles, tendons, ligaments; after operations; with bruises, sprains, dislocations. The patient can consult a pharmacy or his doctor and purchase one of the drugs based on his preferences.

Ask an expert about the topic of the article

Still have questions? Ask them in the comments below and our experts will answer you. There you can also share your experience with other Megatips readers.

Managing editor

Ripatti Yuliya Igorevna,

Expert pharmacist

Share mega advice

Like the article? Tell mom, dad, grandma and aunt Galya from the third entrance

Copy link

Theraflex Chondrocream forte cream 50g with free home delivery from VkusVill

VkusVill

wadded shade color with the smell of dimethyl sulfoxide.

Theraflex Chondrocream forte cream 50g / Pharmacy

Waiting for evaluation

from the partner “Apteka Dialog Sever”

Features of the “Pharmacy” category Online payment only

We deliver partners’ medical products. Can be ordered separately, can be together with the products. Delivery times are the same.

Pharmaceutical partner licenses

Description

Cream from light yellow with a greenish tint to yellow with a greenish tint, with a smell of dimethyl sulfoxide.

Indications for use

The drug is recommended for use as part of complex therapy for degenerative-dystrophic diseases of the musculoskeletal system: osteoarthritis, osteochondrosis of the spine, and other joint diseases accompanied by pain.