What are the main uses of DMSO solution. How effective is DMSO for various conditions. What are the potential side effects and precautions associated with DMSO use. How does DMSO interact with other medications.

Understanding DMSO: Chemical Properties and Medical Applications

Dimethyl sulfoxide (DMSO) is a versatile organic compound with unique chemical properties that make it valuable in both industrial and medical applications. Its ability to penetrate biological membranes and enhance the absorption of other substances has sparked interest in its potential therapeutic uses.

DMSO’s chemical structure allows it to dissolve a wide range of organic and inorganic substances. This property is particularly useful in pharmaceutical formulations, where DMSO can act as a solvent for drugs that are otherwise difficult to administer.

Key Chemical Properties of DMSO

• High polarity
• Excellent solvent capabilities
• Low toxicity
• Ability to penetrate biological membranes

Is DMSO approved for medical use. The U.S. Food and Drug Administration (FDA) has approved DMSO for the treatment of interstitial cystitis, a chronic bladder condition. However, its use for other medical purposes remains largely investigational.

DMSO in the Treatment of Interstitial Cystitis

Interstitial cystitis, also known as painful bladder syndrome, is a chronic condition characterized by bladder pain and urinary frequency. DMSO has shown significant promise in managing this condition.

How does DMSO help in treating interstitial cystitis. DMSO is believed to work through several mechanisms:

1. Reducing inflammation in the bladder lining
2. Blocking pain signals
3. Promoting tissue healing
4. Relaxing bladder muscles

Clinical studies have demonstrated that intravesical instillation of DMSO solution can lead to significant improvement in symptoms for many patients with interstitial cystitis. The treatment typically involves instilling a 50% DMSO solution directly into the bladder through a catheter, with treatments repeated at regular intervals.

Exploring DMSO’s Potential in Pain Management

Beyond its approved use for interstitial cystitis, DMSO has shown promise in managing various pain conditions. One area of particular interest is its potential efficacy in treating complex regional pain syndrome (CRPS).

Can DMSO effectively alleviate pain associated with CRPS. While research is ongoing, preliminary studies suggest that topical application of DMSO cream may help reduce pain and improve function in individuals with CRPS. The exact mechanisms of action are not fully understood, but DMSO’s anti-inflammatory and analgesic properties are thought to play a role.

Other pain conditions where DMSO has been investigated include:

• Osteoarthritis
• Rheumatoid arthritis
• Neuropathic pain
• Sports injuries

While anecdotal reports suggest benefits in these areas, more rigorous clinical trials are needed to establish DMSO’s efficacy and safety for these indications.

DMSO in Dermatology: Potential Applications and Considerations

DMSO’s ability to penetrate the skin has led to interest in its potential dermatological applications. Some areas where DMSO has been explored include:

Wound Healing

Does DMSO promote wound healing. Some studies suggest that topical DMSO may enhance wound healing by reducing inflammation, promoting collagen synthesis, and improving blood flow to the affected area. However, results have been mixed, and more research is needed to establish its efficacy definitively.

Scleroderma

Can DMSO help manage scleroderma symptoms. Despite initial optimism, clinical trials have not demonstrated significant benefits of topical DMSO in treating scleroderma. Current evidence suggests that it may be ineffective for this condition.

Skin Penetration Enhancement

DMSO’s ability to enhance the penetration of other substances through the skin has led to its investigation as a potential vehicle for topical drug delivery. This property could potentially improve the efficacy of various topical medications.

However, it’s crucial to note that this same property can also increase the absorption of potentially harmful substances, highlighting the importance of using DMSO-containing products only under medical supervision.

Understanding DMSO’s Side Effects and Safety Profile

While DMSO has shown promise in various medical applications, it’s essential to understand its potential side effects and safety considerations.

Common Side Effects

What are the most frequently reported side effects of DMSO use. Common side effects include:

• Skin irritation and burning sensation at the application site
• Garlic-like breath odor and taste in the mouth
• Headache
• Nausea
• Dizziness

These side effects are generally mild and transient, but can be bothersome for some patients.

Safety Considerations

Are there any serious safety concerns associated with DMSO use. While DMSO is generally considered safe when used as directed, there are some important safety considerations:

1. Potential for allergic reactions: Some individuals may be allergic to DMSO or develop sensitivity over time.
2. Risk of contamination: Non-pharmaceutical grade DMSO may contain impurities that can be harmful when absorbed through the skin.
3. Interaction with other medications: DMSO can enhance the absorption of other drugs, potentially altering their effects.
4. Long-term effects: The long-term safety of DMSO, particularly for chronic use, is not well established.

Given these considerations, it’s crucial that DMSO be used only under medical supervision and with pharmaceutical-grade products.

DMSO Interactions: Understanding Potential Drug Interactions

DMSO’s unique properties can lead to interactions with various medications and substances. Understanding these interactions is crucial for safe and effective use.

Enhanced Drug Absorption

How does DMSO affect the absorption of other drugs. DMSO can increase the absorption of drugs applied topically or in close proximity to DMSO application. This can potentially lead to increased drug effects and side effects. Some examples include:

• Topical corticosteroids
• Local anesthetics
• Antifungal medications

Healthcare providers should carefully consider this interaction when prescribing DMSO alongside other topical treatments.

Blood Thinners

Does DMSO interact with anticoagulant medications. DMSO may have mild anticoagulant effects of its own. When used in combination with blood thinners like warfarin, heparin, or aspirin, it could potentially increase the risk of bleeding. Patients on anticoagulant therapy should consult their healthcare provider before using DMSO.

Anti-inflammatory Drugs

Are there interactions between DMSO and NSAIDs. Some studies suggest that DMSO might reduce the effectiveness of certain non-steroidal anti-inflammatory drugs (NSAIDs), such as sulindac. Additionally, there’s a theoretical concern that combining DMSO with NSAIDs could increase the risk of gastrointestinal side effects.

Acetylcholinesterase Inhibitors

Can DMSO interact with medications used for Alzheimer’s disease or glaucoma. DMSO may increase levels of acetylcholine in the body. When combined with medications that also increase acetylcholine levels, such as those used to treat Alzheimer’s disease or glaucoma, there’s a potential for additive effects and increased side effects.

Dosing and Administration of DMSO: Guidelines and Considerations

The appropriate dosing and administration of DMSO can vary significantly depending on the specific indication and formulation. It’s crucial to follow medical guidance and use only pharmaceutical-grade products.

Interstitial Cystitis

What is the standard dosing protocol for DMSO in treating interstitial cystitis. For the FDA-approved indication of interstitial cystitis, the typical protocol involves:

• 50% DMSO solution
• 50 mL instilled into the bladder via catheter
• Retained for 15 minutes
• Treatments repeated every 1-2 weeks for 6-8 weeks

This protocol may be adjusted based on individual patient response and tolerability.

Topical Application

How should DMSO be applied topically for pain management. For topical use in pain management, concentrations typically range from 50% to 70% DMSO. Application guidelines often include:

1. Cleaning the application area thoroughly
2. Applying a thin layer of DMSO solution or cream
3. Gently rubbing in until absorbed
4. Applying 2-4 times daily, or as directed by a healthcare provider

It’s important to note that topical DMSO should not be occluded (covered with a bandage) unless specifically instructed by a healthcare provider, as this can increase the risk of skin irritation.

Considerations for Safe Use

What precautions should be taken when using DMSO. To ensure safe use of DMSO, consider the following guidelines:

• Use only pharmaceutical-grade DMSO products
• Avoid applying DMSO to broken or irritated skin
• Do not use DMSO near mucous membranes or eyes
• Wash hands thoroughly after applying DMSO
• Avoid using DMSO with other topical medications unless directed by a healthcare provider
• Monitor for any adverse reactions and discontinue use if they occur

Always consult with a healthcare provider before starting DMSO treatment, especially if you have any pre-existing medical conditions or are taking other medications.

Future Directions: Ongoing Research and Potential Applications of DMSO

While DMSO has been studied for decades, there remains significant interest in exploring its potential applications in various fields of medicine. Ongoing research is focusing on several promising areas:

Neuroprotection

Can DMSO protect against neurological damage. Some preclinical studies suggest that DMSO may have neuroprotective properties, potentially reducing damage from stroke or traumatic brain injury. Research is ongoing to determine if these effects translate to clinical benefits in humans.

Cancer Treatment

Does DMSO have potential applications in cancer therapy. DMSO is being investigated for its potential to enhance the delivery of chemotherapy drugs to tumor cells. Additionally, some studies suggest that DMSO itself may have anti-cancer properties, though much more research is needed in this area.

Tissue Preservation

How might DMSO be used in organ transplantation. DMSO’s ability to penetrate tissues and protect cells from freezing damage has led to its use in cryopreservation. Researchers are exploring ways to optimize DMSO-based preservation solutions for organ transplantation, potentially extending the viability of donor organs.

Drug Delivery Systems

Can DMSO improve drug delivery methods. The unique properties of DMSO make it an interesting candidate for developing novel drug delivery systems. Researchers are exploring its potential to enhance the absorption and efficacy of various medications, particularly for topical and transdermal delivery.

While these areas of research show promise, it’s important to note that much work remains to be done before any new applications of DMSO can be considered safe and effective for clinical use. Rigorous clinical trials and regulatory approval processes will be necessary to establish DMSO’s efficacy and safety for these potential new indications.

As research continues, our understanding of DMSO’s mechanisms of action and potential applications will likely evolve. Healthcare providers and patients should stay informed about the latest developments in DMSO research, while maintaining a cautious and evidence-based approach to its use.

Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Dimethylsulfoxide (DMSO) is a chemical that dissolves many organic and inorganic substances. It’s available as a prescription drug and dietary supplement.

DMSO helps medicines get through the skin and can affect proteins, carbohydrates, fats, and water in the body.

People use DMSO for bladderinflammation (interstitial cystitis), limb pain that usually occurs after an injury, and leakage of an IV drug from the vein into surrounding skin and tissue. It is also used for osteoarthritis, bed sores, stomach ulcers, and many other conditions, but there is no good scientific evidence to support most of these other uses.

Don’t confuse DMSO with Methylsulfonylmethane (MSM). These are not the same.

Uses & Effectiveness ?

Effective for

• Painful bladder syndrome (interstitial cystitis). DMSO is an FDA-approved product for the treatment of this condition. Washing the bladder with DMSO improves some symptoms, such as pain.

Possibly Effective for

• Limb pain that usually occurs after an injury (complex regional pain syndrome). Applying DMSO cream to the skin seems to improve pain in people with this condition.
• Leakage of intravenous (IV) drug from the vein into surrounding skin and tissue (extravasation). Some chemotherapy drugs can cause skin and tissue damage if they leak from the vein. Applying DMSO to the skin might prevent further damage if this happens.

Possibly Ineffective for

• Hardening of skin and connective tissue (scleroderma). Applying DMSO to the skin doesn’t help treat symptoms of scleroderma.

There is interest in using DMSO for a number of other purposes, but there isn’t enough reliable information to say whether it might be helpful.

Side Effects

When taken by mouth: There isn’t enough reliable information to know if DMSO is safe or what the side effects might be.

When applied to the skin: Non-prescription DMSO is possibly unsafe. Some non-prescription DMSO products might be industrial grade. These aren’t intended for human use and can contain impurities that can cause health issues. DMSO is easily absorbed through the skin, so it can carry these impurities into the body. Side effects might include blistering and burning.

When applied inside the bladder: Prescription DMSO is likely safe. Don’t use DMSO products that are not prescribed by a healthcare professional.

Special Precautions and Warnings

When taken by mouth: There isn’t enough reliable information to know if DMSO is safe or what the side effects might be.

When applied to the skin: Non-prescription DMSO is possibly unsafe. Some non-prescription DMSO products might be industrial grade. These aren’t intended for human use and can contain impurities that can cause health issues. DMSO is easily absorbed through the skin, so it can carry these impurities into the body. Side effects might include blistering and burning.

When applied inside the bladder: Prescription DMSO is likely safe. Don’t use DMSO products that are not prescribed by a healthcare professional.

Pregnancy and breast-feeding: There isn’t enough reliable information to know if DMSO is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Certain blood disorders. Injecting DMSO by IV might cause red blood cells to break down. This might be a problem for people with certain blood disorders. DMSO might make these conditions worse.

Kidney problems: DMSO might harm the kidneys. Check with a healthcare provider before using DMSO if you have kidney problems.

Liver problems: DMSO might harm the liver. Check with a healthcare provider before using DMSO if you have liver problems.br/>

Interactions ?

Moderate Interaction

Be cautious with this combination

• DMSO can sometimes increase how much medicine the body absorbs. Applying DMSO to the skin, eyes, or ears at the same time as applying medication can increase how much medicine the body absorbs. This might increase the effects and side effects of the medicine.

• DMSO might slow blood clotting. Taking DMSO along with medications that also slow blood clotting might increase the risk of bruising and bleeding.

• Using DMSO with sulindac might reduce how well sulindac works to treat pain. There is also a concern that using DMSO with sulindac can increase the risk for nerve pain.

• DMSO can increase a chemical in the body called acetylcholine. Some medications that are used for glaucoma, Alzheimer disease, and other conditions, also increase acetylcholine levels. Taking DMSO with these medications might increase the chance of side effects.

• Using DMSO with verteporfin might reduce how well verteporfin works.

• Using DMSO to dissolve platinum agents onto the skin might reduce how well these drugs work to treat cancer. Examples of platinum agents include carboplatin, cisplatin, and oxaliplatin.

Dosing

DMSO has most often been applied to the skin by adults in various forms, including creams, gels, and solutions. It is also applied inside the bladder. DMSO is available as a prescription and in dietary supplements. Speak with a healthcare provider before use.

View References

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.

DMSO: Uses and Risks

Written by Joseph Saling

• Why Do People Use DMSO?
• What Are the Risks of Using DMSO?

DMSO, or dimethyl sulfoxide, is a by-product of paper making. It comes from a substance found in wood.

DMSO has been used as an industrial solvent since the mid-1800s. From about the mid-20th century, researchers have explored its use as an anti-inflammatory agent.

The FDA has approved DMSO as a prescription medication for treating symptoms of painful bladder syndrome. It’s also used under medical supervision to treat several other conditions, including shingles.

DMSO is easily absorbed by the skin. It’s sometimes used to increase the body’s absorption of other medications.

DMSO is available without a prescription most often in gel or cream form. It can be purchased in health food stores, by mail order, and on the Internet.

While it can sometimes be found as an oral supplement, its safety is unclear. DMSO is primarily used by applying it to the skin.

DMSO has been used to try to relieve the pain of osteoarthritis. It has also been promoted as an “alternative” cancer treatment.

People have used it to try to treat wounds, burns, and other injuries. People have also used it to try to treat such conditions as:

• Headache
• Rheumatoid arthritis
• Eye problems
• Scars
• Scleroderma (disease that causes scar tissue to form in the skin)

Other than its use as a prescription medicine, there is little or no scientific evidence to support other claims made about DMSO’s effectiveness.

The American Cancer Society says there is no evidence to support the use of DMSO to treat cancer. Using it that way could cause serious delays in getting proper and effective treatment.

A recent analysis of studies on the use of DMSO to relieve osteoarthritis pain found that it was not significantly more effective than placebo in relieving joint pain.

There are no studies that provide guidelines for determining the proper dose of DMSO. The gel used to treat osteoarthritis typically has a concentration of 25%. It is applied three or four times a day. But DMSO sold without a prescription can range from 10% concentration to 90%.

Some DMSO on the market may actually be industrial grade. Industrial grade DMSO may contain a number of impurities that can easily be absorbed into the skin with potentially serious health effects.

The most frequent side effects from using DMSO on the skin include:

• Stomach upset
• Skin irritation
• Strong odor of garlic

More serious side effects include:

• Severe allergic reactions
• Headaches
• Itching and burning when applied to the skin

DMSO can also cause a deadly reaction when used in high concentrations.

Using DMSO by mouth can cause:

• Dizziness
• Drowsiness
• Nausea
• Vomiting
• Diarrhea
• Constipation
• Decreased appetite

DMSO can increase the effect of some medicines, which can lead to serious health issues. Examples of such medicines include:

• Blood thinners
• Steroids
• Sedatives

The biggest concern of DMSO as a solvent is that when it gets on the skin it will cause anything on the skin to be absorbed. So be sure to wash your hands and skin well before using.

Pregnant women and women who are breastfeeding should not use DMSO, since little is known about its possible effects on the fetus or infant.

You should also not use DMSO without talking to your doctor if you have:

• Diabetes
• Asthma
• Liver and kidney conditions

Always keep in mind that supplements are not regulated by the FDA the same was as drugs are. The manufacturer does not have to prove that a supplement is safe or effective before selling.

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Provided by Lexicomp ^® , this document contains all the information you need to know about this medicine, including indications, directions for use, side effects, and when your healthcare provider should be contacted.

Trade names: USA

Rimso-50

Trade names: Canada

Rimso-50

What is this drug used for?

• It is used to relieve pain, reduce inflammation and reduce bladder irritation.
• If you have been taking this drug for any other reason, ask your doctor about the benefits and risks. If you have questions or concerns about using this drug, talk with your doctor.

What should I tell my doctor BEFORE taking this drug?

• If you have an allergy to this drug, any of its ingredients, other drugs, foods or substances. Tell your doctor about your allergies and how they have manifested.

Combining this drug with certain drugs and conditions may be unfavorable.

Tell your doctor and pharmacist about all medicines you take (prescription and over-the-counter, natural products and vitamins) and any health problems you have. You need to make sure that this drug is safe for your conditions and in combination with other drugs you are already taking. Do not start or stop taking any drug or change the dosage without your doctor’s advice.

What do I need to know or do while taking this drug?

• Tell all your health care workers that you are taking this drug. These are doctors, nurses, pharmacists and dentists.
• Get a blood test and an eye exam as directed by your doctor.
• Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding. The benefits and risks for you and your child will need to be discussed.

What side effects should I report to my doctor immediately?

WARNING. In rare cases, this drug can cause serious and sometimes deadly side effects in some patients. Contact your doctor or seek medical attention right away if you have any of the following signs or symptoms that may be associated with serious side effects:

• Signs of an allergic reaction, such as rash, hives, itching, red and swollen skin with blisters or peeling, possibly accompanied by fever, wheezing or wheezing, tightness in the chest or throat, difficulty breathing, swallowing or speaking, unusual hoarseness, swelling in the mouth, face, lips, tongue or throat.
• Vision changes, eye pain or severe eye irritation.

What are some other side effects of this drug?

Any medicine can have side effects. However, for many people, side effects are either minor or non-existent. Contact your doctor or seek medical attention if these or any other side effects bother you or do not go away:

• Irritation at the site of application of the drug.
• When taking this drug, the skin and breath acquired a smell reminiscent of garlic. The odor may persist for up to 72 hours after using this drug.

This list of possible side effects is not exhaustive. If you have any questions about side effects, please contact your doctor. Talk to your doctor about side effects.

You can report side effects to the National Health Board.

You can report side effects to the FDA at 1-800-332-1088. You can also report side effects at https://www.fda.gov/medwatch.

What is the best way to take this drug?

Use this drug as directed by your doctor. Read all the information provided to you. Strictly follow all instructions.

• The drug is injected through a catheter into the bladder.
• You need to urinate after taking this drug. This helps to remove the drug from the bladder. Drink large amounts of decaffeinated fluids during or immediately after taking this drug, unless your doctor tells you otherwise. Continue drinking fluids as directed by your doctor.

What if I miss a dose of a drug?

• See your doctor for further instructions.

How do I store and/or discard this drug?

• If you need to store this drug at home, check with your doctor, nurse, or pharmacist for storage conditions.

General information about medicines

• If your health does not improve or even worsens, see your doctor.
• Do not give your medicine to anyone and do not take other people’s medicines.
• Keep all medicines in a safe place. Keep all medicines out of the reach of children and pets.
• Dispose of unused or expired drugs. Do not empty into a toilet or sewer unless instructed to do so. If you have any questions about disposing of medicines, ask your pharmacist. Drug disposal programs may be in place in your area.
• Some medicines may come with other patient information leaflets. If you have any questions about this drug, talk with your doctor, nurse, pharmacist, or other health care professional.
• Some medicines may come with other patient information leaflets. Check with your pharmacist. If you have any questions about this drug, talk with your doctor, nurse, pharmacist, or other health care professional.
• If you think you have overdosed, call a poison control center or get medical help right away. Be prepared to tell or show what drug you took, how much, and when it happened.

Consumer Use of Information and Limitation of Liability

This summary information includes a summary of the diagnosis, treatment, and/or drug product. It is not intended to be a comprehensive source of data and should be used as a tool to help the user understand and/or evaluate potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a particular patient. It should not be considered medical advice or a substitute for medical advice, diagnosis or treatment provided by a physician based on a medical examination and assessment of the patient’s specific and unique circumstances. Patients should consult with their physician for full information about their health, medical issues, and treatment options, including any risks or benefits regarding the use of medications. This information is not a guarantee that a treatment or drug is safe, effective, or approved for a particular patient. UpToDate, Inc. and its subsidiaries disclaim any warranties or liabilities related to this information or its use. The use of this information is subject to the Terms of Use found at https://www. wolterskluwer.com/en/know/clinical-effectiveness-terms.

Last revision date

2021-06-25

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Date last updated

Monday, December 12, 2022

Description DIMETHYL SULFOXIDE indications, dosages, contraindications of the active substance DIMETHYL SULFOXIDE

Rec.INN registered by WHO Included in preparations: list Pharmacological action Anti-inflammatory agent for external use. The mechanism of action is associated with the inactivation of hydroxyl radicals and the improvement of metabolic processes in the focus of inflammation, a decrease in the rate of conduction of excitatory impulses in peripheral neurons. It has a local anesthetic, local anti-inflammatory, analgesic and antimicrobial effect; has some fibrinolytic activity. Penetrates through the skin and other biological membranes, increases their permeability to drugs. Pharmacokinetics When a solution of dimethyl sulfoxide is applied to the skin, it is detected in the blood after 5 minutes, C max is reached after 4-6 hours, maintaining an almost unchanged level for 1.5-3 days. Dimethyl sulfoxide is excreted in the urine and feces, both unchanged and as dimethyl sulfone. Indications of the active substance DIMETHYLSULPHOXIDE As part of complex therapy: diseases of the musculoskeletal system: rheumatoid arthritis, ankylosing spondylitis (Bekhterev’s disease), deforming osteoarthrosis (in the presence of damage to periarticular tissues), reactive synovitis, limited scleroderma, erythema nodosum, discoid lupus erythematosus, mycosis of the feet, keloid scars, thrombophlebitis, alopecia, eczema, streptoderma, erysipelas; bruises, sprains, traumatic infiltrates; purulent wounds, burns, sciatica, trophic ulcers, acne, furunculosis; in skin plastic surgery – for preservation of skin homotransplants. Open list of ICD-10 codes A46 erysipelas B35.3 Foot mycosis I80 Phlebitis and thrombophlebitis L02 Skin abscess, furuncle and carbuncle L08.0 Pyoderma L20.8 Other atopic dermatitis (neurodermatitis, eczema) L30.0 Coin-shaped eczema L52 Erythema nodosum L63.9 Alopecia areata, unspecified L64. 9 Androgenetic alopecia, unspecified L70 Acne L91.0 Hypertrophic scar L93.0 Discoid lupus erythematosus L94.0 Localized scleroderma [morphea] L98.4 Chronic skin ulcer, not elsewhere classified M05 Seropositive rheumatoid arthritis M15 Polyarthrosis M45 Ankylosing spondylitis M54.1 Radiculopathy M54. 3 Sciatica M54.4 Lumbago with sciatica M65 Synovitis and tenosynovitis T14.0 Superficial injury of an unspecified area of ​​the body (incl. abrasion, bruising, contusion, hematoma, non-venomous insect bite) T14.3 Dislocation, sprain and strain of the capsular-ligamentous apparatus of the joint of an unspecified area of ​​the body T30 Thermal and chemical burns, unspecified T79.3 Post-traumatic wound infection, not elsewhere classified Dosing regimen Apply externally. In the form of applications and irrigations (washings). The concentration of the solution and the solvent is determined depending on the application. The duration of treatment is 10-15 days. Side effects Possible: allergic reactions, pruritic dermatitis, contact dermatitis, erythema, dry skin, mild burning, pruritic dermatitis. Rare: bronchospasm. Contraindications for use Hypersensitivity to dimethyl sulfoxide; severe hepatic and / or renal failure, angina pectoris, severe atherosclerosis, glaucoma, cataracts, stroke, coma, myocardial infarction; pregnancy; breastfeeding period; children’s age up to 12 years. Use in pregnancy and lactation Dimethyl sulfoxide is contraindicated in pregnancy and lactation. Use in hepatic impairment Contraindicated in severe hepatic impairment. Use in impaired renal function Contraindicated in severe renal impairment. Use in children Use in children under 12 years of age is contraindicated. Leave a Reply Cancel reply Your email address will not be published. Required fields are marked * Comment * Name * Email * Website