How does Bystolic affect weight. What are the potential side effects of this beta-blocker on body mass. Can Bystolic cause weight gain or promote weight loss. What do studies reveal about Bystolic’s impact on weight management.

Understanding Bystolic: A Novel Beta-Blocker for Hypertension

Bystolic, also known by its generic name nebivolol, is a medication primarily used to treat high blood pressure (hypertension). As a third-generation beta-blocker, it offers unique properties that set it apart from older drugs in its class. But how does Bystolic impact body weight, and what should patients know about its potential effects on their weight management efforts?

What is Bystolic and How Does it Work?

Bystolic belongs to a class of medications called beta-blockers. These drugs work by blocking the effects of epinephrine, also known as adrenaline, on the heart and blood vessels. By doing so, they help to lower blood pressure and reduce the workload on the heart.

What makes Bystolic unique among beta-blockers? It has the ability to dilate blood vessels through increased production of nitric oxide, a vasodilatory chemical. This dual action of blocking beta-1 receptors and promoting vasodilation contributes to its effectiveness in managing hypertension.

The Beta-Blocker Paradox: Weight Gain vs. Weight Loss

Traditionally, beta-blockers have been associated with weight gain. Dr. Sheldon Sheps, writing for the Mayo Clinic, notes that most beta-blockers tend to cause a modest increase in weight, typically less than 4 pounds. This effect is particularly noticeable with older beta-blockers such as metoprolol and atenolol.

Why do beta-blockers typically cause weight gain? There are two primary theories:

• Metabolic slowing: Beta-blockers may reduce the body’s metabolic rate, leading to fewer calories burned at rest.
• Water retention: Some patients may experience increased fluid retention, especially if they discontinued a diuretic to start the beta-blocker.

However, Bystolic seems to challenge this conventional wisdom. A study published in the Journal of Cardiovascular Pharmacology in September 2010 suggests that Bystolic may actually promote modest weight loss in some individuals.

Bystolic and Weight Loss: Examining the Evidence

The 2010 study by Dennis Ladage and colleagues involved approximately 5,000 people with type 2 diabetes and high blood pressure. Participants took Bystolic for a 12-week period, and at the end of the study, researchers observed an average weight loss of about 2 pounds among the participants.

While these findings are intriguing, it’s important to note that this is currently the only study examining the association between Bystolic and weight loss. Further research is needed to confirm or refute these results.

Interpreting the Weight Loss Findings

How significant is a 2-pound weight loss over 12 weeks? While any weight loss can be beneficial, especially for individuals with hypertension and diabetes, it’s a relatively modest amount. For context, the National Institutes of Health’s Medline Plus project recommends a weight loss of 1 to 2 pounds per week for individuals actively trying to lose weight.

Is Bystolic an effective weight loss medication? No, it’s crucial to understand that Bystolic is not intended or approved as a weight loss agent. Its primary purpose remains the treatment of hypertension. Any potential weight loss effects should be considered a secondary benefit, not a primary reason for use.

Potential Mechanisms Behind Bystolic’s Weight Effects

To understand why Bystolic might have a different effect on weight compared to other beta-blockers, it’s helpful to explore the relationship between the sympathetic nervous system and body weight regulation.

The Role of the Sympathetic Nervous System in Weight Regulation

The sympathetic nervous system plays a crucial role in regulating energy expenditure and fat metabolism. Some researchers have proposed that reduced sympathetic activity may contribute to the development of obesity. This theory, known as the MONA LISA (Most Obesities kNown Are Low In Sympathetic Activity) hypothesis, suggests that interventions targeting the sympathetic nervous system could potentially aid in weight management.

How might Bystolic influence this system differently from other beta-blockers? Its unique ability to promote nitric oxide production and vasodilation may play a role, but more research is needed to fully understand the mechanisms at work.

Comparing Bystolic to Other Beta-Blockers: Weight Effects

When considering the potential weight effects of Bystolic, it’s important to compare it to other medications in its class. How does Bystolic stack up against other beta-blockers in terms of weight management?

Traditional Beta-Blockers and Weight Gain

Older beta-blockers, such as metoprolol and atenolol, are more commonly associated with weight gain. The average weight gain with these medications is typically modest, usually less than 4 pounds. However, for patients struggling with weight management, even a small increase can be concerning.

Third-Generation Beta-Blockers and Weight

Bystolic belongs to a newer generation of beta-blockers, sometimes referred to as third-generation beta-blockers. These medications often have additional properties beyond simple beta-blockade, which may influence their effects on body weight.

Are all third-generation beta-blockers associated with weight loss? Not necessarily. The effects can vary between different medications and individual patients. More research is needed to fully understand how these newer beta-blockers impact weight management.

Patient Considerations: Bystolic and Weight Management

For patients prescribed Bystolic, understanding its potential effects on weight can help in managing expectations and planning for overall health. What should patients keep in mind when taking Bystolic?

Monitoring Weight Changes

Patients taking Bystolic should monitor their weight regularly and discuss any significant changes with their healthcare provider. While the medication may have a neutral or slightly positive effect on weight for some individuals, responses can vary.

Focusing on Overall Health

Is weight loss a guaranteed effect of taking Bystolic? No, and it’s important for patients to maintain a focus on overall health rather than relying on medication for weight management. A balanced diet and regular exercise remain the most effective strategies for weight control.

Discussing Concerns with Healthcare Providers

Patients who are concerned about the potential weight effects of Bystolic should discuss these concerns with their healthcare provider. In some cases, alternative medications or additional strategies for weight management may be appropriate.

Beyond Weight: Other Considerations with Bystolic

While weight management is an important consideration for many patients, it’s just one aspect of overall health. What other factors should patients and healthcare providers consider when using Bystolic?

Efficacy in Blood Pressure Control

The primary purpose of Bystolic is to manage hypertension. How effective is Bystolic in controlling blood pressure? Studies have shown that Bystolic is an effective antihypertensive medication, with the added benefit of once-daily dosing for many patients.

Potential Side Effects

Like all medications, Bystolic can cause side effects. Common side effects may include:

• Headache
• Fatigue
• Dizziness
• Nausea

Patients should report any persistent or severe side effects to their healthcare provider.

Drug Interactions

Bystolic can interact with other medications. Patients should inform their healthcare provider about all medications, supplements, and herbal products they are taking to avoid potential interactions.

Future Research Directions: Bystolic and Weight Management

The potential weight effects of Bystolic open up interesting avenues for future research. What questions remain to be answered about Bystolic and weight management?

Long-Term Weight Effects

The current study on Bystolic and weight loss only covered a 12-week period. What are the long-term effects of Bystolic on body weight? Future studies with longer follow-up periods could provide valuable insights.

Mechanisms of Action

While the study by Ladage and colleagues observed weight loss in patients taking Bystolic, the exact mechanisms behind this effect are not fully understood. Further research into how Bystolic influences metabolism and energy expenditure could shed light on these processes.

Comparative Studies

How does Bystolic compare to other beta-blockers and antihypertensive medications in terms of weight effects? Comparative studies could help healthcare providers make more informed decisions when choosing medications for patients with hypertension and weight concerns.

In conclusion, while Bystolic has shown potential for modest weight loss in one study, it’s important to remember that its primary purpose is the treatment of hypertension. Patients should work closely with their healthcare providers to monitor any weight changes and maintain a focus on overall health, including a balanced diet and regular exercise. As research continues, we may gain a clearer understanding of how Bystolic and other third-generation beta-blockers influence body weight and metabolism.

Bystolic & Weight Loss | Healthfully

Bystolic, a high blood pressure medication, has been demonstrated to have a modest effect on weight loss. However, to date, only one study has demonstrated this effect, and if weight loss is truly your goal, a healthful diet and exercise are likely to be more effective.

About Bystolic

Bystolic, or nebivolol, is a type of drug known as a beta-blocker. It binds to beta-1 receptors on heart muscle and causes a decrease in blood pressure. It also has the rare ability to dilate blood vessels because of its effects mediated by increased nitric oxide production, a vasodilatory chemical, according to Thomas and David Westfall in “Goodman and Gilman’s Pharmacology.”

Beta Blockers and Weight Gain

Concerta & Weight Loss

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According to Dr. Sheldon Sheps, who writes for the Mayo Clinic, most beta blockers tend to cause weight gain — not loss 2. This is particularly the case with older beta blockers, including metoprolol and atenolol. The average weight gain is not dramatic — usually less than 4 lb. — but doctors don’t necessarily understand why it occurs. Sheps says it could either be due to metabolic slowing as a result of the beta blocker, or of increased water retention, particularly if you discontinued a diuretic to start the beta blocker.

• According to Dr. Sheldon Sheps, who writes for the Mayo Clinic, most beta blockers tend to cause weight gain — not loss 2.

Bystolic and Weight Loss

Despite the classic association of beta blockers with weight gain, one study of Bystolic suggests that it may promote modest weight loss in some people 2. In the September 2010 issue of the Journal of Cardiovascular Pharmacology, Dennis Ladage and colleagues report the results of a study in which about 5,000 people with type 2 diabetes and high blood pressure took Bystolic during a 12-week period 3. At the end of the 12 weeks, an average weight loss of about 2 lb. was noted in study participants.

Impact of Study

Differences Between Strattera & Concerta

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Although Ladage and colleagues demonstrated a modest amount of weight loss in their population, theirs is the only study to date that examines the association between Bystolic and weight loss. Other studies need to be performed to confirm or refute its findings. As well, an approximately 2 lb. weight loss over 12 weeks is not a large weight loss. Medline Plus, a project of the National Institutes of Health, recommends a weight loss of 1 to 2 lb. per week in an individual trying to lose weight.

• Although Ladage and colleagues demonstrated a modest amount of weight loss in their population, theirs is the only study to date that examines the association between Bystolic and weight loss.

The bottom line is that Bystolic is intended to be used as a high blood pressure medication. It might have some effect on weight loss, but based on the best available data to date, it shouldn’t be relied upon as a weight loss agent. As always, the best advice for someone trying to lose weight is to eat a healthful diet and get plenty of exercise.

Effect of Third-Generation Beta Blockers on Weight Loss in a Population of Overweight-Obese Subjects in a Controlled Dietary Regimen

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Bystolic Tablets (Nebivolol Tablets) Side Effects, Warnings, Methods of Use

• Generic Name: Nebivolol Tablets
• Brand Name: Bystolic Tablets

• Overview
• Consumer Information

9 0009 Professional Information

• Related Resources

Bystolic Tablets Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What is bystolic?

Bystolic (nebivolol) is a beta-blocker used to treat high blood pressure (hypertension).

What are the side effects of Bystolic?

Side effects of Bystolic include:

• Headache,
• dizziness,
• fatigue,
• fatigue,

9 0009 slow heartbeat,

• nausea,
• abdominal pain,
• diarrhea,
• trouble sleeping (insomnia),
• numbness or coldness in the hands and feet,
• shortness of breath,
• rash, or
• fluid retention in the legs.

Dosage for Bystolic?

The dose of Bystolic is selected individually according to the needs of the patient. For most patients, the recommended starting dose of Bystolic is 5 mg once daily, with or without food, as monotherapy or in combination with other agents.

What drugs, substances or supplements do Bystolic interact with?

Bystolic may interact with cimetidine, clonidine, digitalis, isoniazid, methimazole, reserpine, ropinirole, ticlopidine, other beta-blockers, antibiotics, antidepressants, antimalarials, heart or blood pressure medicines, heart rhythm medicines, HIV medicines, or AIDS or medication to treat mental disorders. Tell your doctor about all medications and supplements you are taking.

Bystolic during pregnancy and lactation

Tell your doctor if you are pregnant or plan to become pregnant while using Bystolic; it is not known if Bystolic will harm the fetus. It is not known if Bystolic passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.

More Information

Our Bystolic Side Effects Drug Center provides a comprehensive overview of available drug information about the potential side effects of this medication.

This is not a complete list of side effects and they may occur. Ask your doctor about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

Consumer Information Bystolic Tablets

Get emergency medical help if you have signs of an allergic reaction: hives; labored breathing; swelling of the face, lips, tongue, or throat.

Call your doctor right away if you have:

• feeling dizzy, as if you could pass out;
• rapid weight gain;
• shortness of breath;
• slow or irregular heartbeat; or
• numbness or coldness in hands and feet.

Common side effects may include:

alprazolam 1 mg vs xanax

• dizziness;
• swelling of the legs;
• slow heartbeat;
• fatigue; or
• Headache.

This is not a complete list of side effects and they may occur. Ask your doctor about side effects. You can report side effects to the FDA at 1-800-FDA-1088. bystolic tablets with arterial hypertension and in patients with heart failure. The observed profile of adverse reactions was consistent with the pharmacology of the drug and the health status of patients in clinical trials. Adverse reactions reported for each of these patient groups are presented below. Excluded are adverse reactions that are considered too general to be informative, and adverse reactions that have not been reasonably associated with the use of the drug, because they were associated with the disease being treated or very common in the population receiving treatment.

The data below reflect the worldwide exposure of BYSTOLIC to 6545 patients, including 5038 patients treated for hypertension and the remaining 1507 patients treated for other cardiovascular conditions. Doses ranged from 0.5 mg to 40 mg. Patients received BYSTOLIC for up to 24 months, more than 1900 patients were treated for at least 6 months and approximately 1300 patients for more than one year.

HYPERTENSION

In placebo-controlled clinical trials comparing BISTOLIC with placebo, discontinuation due to adverse reactions was reported in 2. 8% of patients treated with nebivolol and 2.2% of patients treated with placebo. The most common adverse reactions that led to the discontinuation of BYSTOLIC were headache (0.4%), nausea (0.2%) and bradycardia (0.2%).

Table 1 lists treatment-related adverse reactions reported in three 12-week placebo-controlled monotherapy studies in 1597 hypertensive patients treated with BYSTOLIC 5 mg, 10 mg, or 20-40 mg and 205 placebo-treated patients for whom the incidence was at least 1% of patients treated with nebivolol and exceeded the incidence of placebo treatment in at least one dose group.

Table 1: Adverse reactions occurring after treatment, with a frequency (more than 6 weeks) & ge; 1% in patients treated with BYSTOLIC and at a higher frequency than in patients treated with placebo

9015 8

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reported adverse reactions with a frequency of at least 1% in more than 4300 patients who received BYSTOLIC in controlled or open studies for With the exception of those already listed in Table 1, the terms are too general to be informative, minor symptoms, or adverse reactions that are unlikely to be associated with the drug, as they are common in the population. These adverse reactions in most cases were observed with the same frequency in patients receiving placebo in controlled studies.

Body as a whole: asthenia.

Diseases of the gastrointestinal tract: abdominal pain

Metabolic and nutritional disorders: hypercholesterolemia

Diseases of the nervous system: paresthesia

La boratory abnormalities

In controlled monotherapy trials in patients with hypertension, BYSTOLIC was associated with an increase in BUN, uric acid, triglycerides and a decrease in HDL cholesterol and platelet count.

Post-marketing experience

The following adverse reactions have been identified from spontaneous reports of BYSTOLIC worldwide and have not been listed elsewhere. These adverse reactions were selected for inclusion due to a combination of severity, frequency of reporting, or potential causal association with BYSTOLIC. Adverse reactions specific to the population are usually not mentioned. Because these adverse reactions have been reported voluntarily in a population of uncertain size, it is not possible to estimate their frequency or establish a causal relationship with BYSTOLIC exposure: hepatic impairment (including elevation of AST, ALT and bilirubin), acute pulmonary edema, acute renal failure, atrioventricular block (second and third degree), bronchospasm, erectile dysfunction, hypersensitivity (including urticaria, allergic vasculitis, and rare reports of angioedema), hypotension, myocardial infarction, pruritus, psoriasis, Raynaud’s phenomenon, peripheral ischemia / lameness, syncope, thrombocytopenia, various rashes and skin sickness, dizziness and vomiting.

Read all FDA Prescribing Information for Bystolic Tablets (Nebivolol Tablets)

Read More’ Related Resources for Bystolic Tablets

Associated Health

• Treating High Blood Pressure (Natural Home Remedies, Diet, Medications)

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• Atakand HCT
• Bumex
• Caduet
• Cardizem LA
• Cardura 9Hct 9 0004
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Read Bystolic Tablets User Reviews»

Tablets is provided by Cerner Multum, Inc. and Bystolic Tablets consumer information is provided by First Databank, Inc., used under license and subject to their respective copyrights.

Everything you need to know about beta blockers – Drink-Drink

07/07/2022 DrinkDrinkAdmin

Contents

• What are beta blockers?
• Types of beta blockers and how they work
• What are beta blockers used for?
• Side effects
• Interactions and warnings
• Can beta-blockers be stopped?
• Conclusion

What are beta-blockers?

Beta-blockers are a class of drugs used to block the effects of stress hormones such as adrenaline on the heart. They are often prescribed for irregular heartbeats, high blood pressure, and after heart attacks.

Less commonly, beta-blockers may be used to treat:

• glaucoma
• migraine
• anxiety disorders
• hyperthyroidism
• tremor

90 020 Doctors usually turn to beta-blockers for high blood pressure when other medications such as diuretics do not work or have too many side effects.

Beta blockers may be used with other blood pressure medications, including ACE inhibitors and calcium channel blockers.

Beta-blockers have been shown to have some health benefits beyond helping the heart. For example, they protect bones by preventing the kidneys from excreting calcium in the urine and block stress hormones that could otherwise cause bone thinning over time.

Types of beta blockers and how they work

Because of the way they work in the body, beta blockers are also called beta blockers.

Different types of beta blockers work differently. Generally, these medicines improve the ability of the heart to relax. Your heart will beat slower and less strongly when beta blockers are working. It can help lower blood pressure and alleviate irregular heart rhythms.

Some beta-blockers affect only the heart itself, others affect the heart and blood vessels.

Your doctor may prescribe beta-blockers even if you have few symptoms of heart problems or heart failure. These medications can actually improve the heart’s ability to beat. Acebutolol (Sektral)0004

90 007

Beta-blockers are available in a variety of forms and routes of administration, including oral, intravenous and ophthalmic.

Beta-blockers are usually taken once or twice a day with meals and should usually be taken at the same time each day.

Always take your medicines as directed. Tell your doctor if you have any side effects. You should not stop taking a beta-blocker without first talking to your doctor.

What are beta-blockers used for?

Beta-blockers are used to decrease heart rate and lower blood pressure. They do this by preventing the hormone adrenaline, as well as other stress hormones, from binding to beta receptors throughout the body.

Beta blockers FDA approved for heart disease and blood pressure, including:

• tachycardia
• high blood pressure (hypertension)
• heart attack (myocardial infarction)
• chronic heart failure
• cardiac arrhythmia
• coronary artery disease

9000 9 overactive thyroid (hyperthyroidism)

• essential tremor
• aortic dissection
• portal hypertension

Beta-blockers are sometimes prescribed off-label by doctors for other conditions, including:

• glaucoma
• migraine
• anxiety disorders
• hyperthyroidism
• tremor

Side effects

Side effects these drugs may be different. Many people will experience:

• fatigue
• cold hands
• headache
• digestive problems
• constipation
• diarrhea
• dizziness 9000 4

Rarely, you may experience:

• shortness of breath
• trouble sleeping
• Decreased libido
• Depression

If you accidentally take a higher dose than recommended, you may experience:

• shortness of breath
• changes in vision
• dizziness
• arrhythmia
• confusion

If you know you have overdosed, call your doctor or local poison control center. US National Poison Center phone number: 800-222-1222.

Some older beta blockers such as atenolol and metoprolol have been reported to cause weight gain. Fluid retention and associated weight gain may be signs of heart failure or worsening heart failure.

Be sure to tell your doctor if you gain more than 2-3 pounds in a day, gain more than 5 pounds in a week, or your symptoms get worse.

You may also notice some changes in how your heart works in your daily life. For example, beta-blockers prevent heart rate spikes. You may notice that your heart rate does not rise as high as it normally does during exercise.

Talk to your doctor if you are concerned about your exercise while taking this medicine. They may recommend a stress test to determine your target heart rate during cardio.

Stress tests can also help your doctor determine how hard you work during your workout. This is known as the perceived load level.

Interactions and warnings

Other medicines may increase or decrease the effect of beta-blockers, so be sure to tell your doctor about all medicines, vitamins, and herbal supplements you are taking.

Beta-blockers may interact with drugs such as:

• ACE inhibitors
• allergy medicines such as ephedrine, norepinephrine or epinephrine
• alpha-blockers
• anesthetics 90 004
• antiarrhythmic drugs
• antiulcer drugs
• antidepressants
• antihypertensive and antianginal drugs
• asthma drugs
• calcium channel blockers
• digitalis glycosides
• HMG-CoA reductase inhibitors
• inotropic agents
• isoproterenol and dobutamine
• antipsychotics
• non-steroidal anti-inflammatory drugs (NSAIDs)
• oral hypoglycemic drugs
• other drugs for blood pressure
• psychotropic drugs
• reserpine
• rifampicin (also known as rifampicin)
• thyroxine
• warfarin

Beta-blockers should not be used people with:

• history of fluid retention without the use of diuretics
• severe heart failure
• Raynaud’s disease

Historically that beta-blockers are contraindicated in people with asthma, but this group it is safe to use cardioselective beta-blockers, also known as beta-1-selective.