How much caffeine is in Excedrin Migraine. What is the recommended dosage for adults. How effective is Excedrin Migraine for relieving migraine pain. What are the potential side effects and warnings associated with Excedrin Migraine.

Caffeine Content in Excedrin Migraine

Excedrin Migraine is an over-the-counter (OTC) medication designed to provide relief from migraine pain. One of its key ingredients is caffeine, which plays a significant role in enhancing the effectiveness of the pain-relieving components. But how much caffeine does Excedrin Migraine actually contain?

Each tablet of Excedrin Migraine contains:

• 65 milligrams (mg) of caffeine
• 250 mg of acetaminophen
• 250 mg of aspirin

The standard adult dose of Excedrin Migraine is two tablets, which means a full dose provides 130 mg of caffeine. To put this into perspective, this amount of caffeine is roughly equivalent to an 8-12 ounce cup of coffee.

Recommended Dosage and Administration

Proper dosage is crucial for the safe and effective use of Excedrin Migraine. How should one take this medication?

• The regular dosage for adults is 2 tablets with a glass of water.
• Do not exceed two tablets in any 24-hour period unless directed by a doctor.
• If symptoms worsen or persist, consult your healthcare provider.
• Individuals under 18 years of age should consult a doctor before use.

It’s important to note that Excedrin Migraine can work quickly, with some people experiencing relief as soon as 30 minutes after taking the medication. However, the effectiveness and onset of action can vary among individuals.

Caffeine Consumption Precautions

When taking Excedrin Migraine, it’s advisable to limit the consumption of other caffeine-containing products. Why is this necessary?

Excessive caffeine intake can lead to several side effects, including:

• Nervousness
• Irritability
• Sleeplessness
• Rapid heartbeat

By being mindful of your overall caffeine consumption, you can minimize the risk of these adverse effects while still benefiting from the pain-relieving properties of Excedrin Migraine.

The Role of Caffeine in Migraine Relief

Caffeine is more than just an added ingredient in Excedrin Migraine. It plays a crucial role in enhancing the effectiveness of the medication. How does caffeine contribute to migraine relief?

Research has shown that caffeine can increase the effects of pain relievers like aspirin and acetaminophen, making these medicines more effective in treating migraines. This synergistic effect is why caffeine is included in the Excedrin Migraine formula.

Interestingly, the relationship between caffeine and migraines is complex. For some individuals, caffeine can trigger a migraine headache. However, when combined with acetaminophen and aspirin, it has been demonstrated to be beneficial in managing migraine pain.

Effectiveness of Excedrin Migraine

The efficacy of Excedrin Migraine has been extensively studied. What does the research say about its effectiveness in treating migraine pain?

Three double-blind, randomized, and placebo-controlled studies involving 1220 participants assessed the effectiveness of the OTC combination of acetaminophen, aspirin, and caffeine in alleviating moderate-to-severe migraine headache pain. The results were promising:

• Significantly greater reduction in migraine pain intensity 1 to 6 hours after dosing compared to placebo
• Over 59% of patients experienced reduction of pain to mild or none 2 hours after dosing, compared to about 33% in the placebo group
• At 6 hours post-dose, 79% of treated patients had pain reduced to mild or none, versus 52% in the placebo group
• 51% of treated patients were pain-free at 6 hours, compared to 24% in the placebo group
• Improvement in associated symptoms such as nausea, photophobia, phonophobia, and functional disability 2 to 6 hours after treatment

These findings suggest that Excedrin Migraine can be an effective OTC option for many individuals suffering from migraine headaches.

Potential Side Effects and Warnings

While Excedrin Migraine can be effective in treating migraine pain, it’s essential to be aware of potential side effects and warnings associated with its use. What are the main concerns to keep in mind?

Excedrin Migraine is associated with several warnings and potential side effects, some of which may be severe:

• Reye’s Syndrome: A rare but serious condition that can occur in children and teenagers
• Risk of allergy: Particularly to aspirin or other NSAIDs
• Liver toxicity: Due to the acetaminophen content
• Stomach bleeding: A potential risk associated with aspirin use
• Headache rebound: Due to medication overuse
• Caffeine overuse: Can lead to dependence and withdrawal symptoms

It’s crucial to follow the recommended dosage and consult with a healthcare provider if you have any concerns or pre-existing conditions.

Comparing Excedrin Migraine to Other OTC Headache Medications

Excedrin Migraine is one of several OTC options available for headache relief. How does it compare to other common headache medications?

Unlike single-ingredient pain relievers, Excedrin Migraine combines three active ingredients: acetaminophen, aspirin, and caffeine. This combination approach sets it apart from other OTC headache medications:

• Acetaminophen (e.g., Tylenol): Works primarily by reducing pain signals in the brain
• Ibuprofen (e.g., Advil): An NSAID that reduces inflammation and pain
• Naproxen (e.g., Aleve): Another NSAID with longer-lasting effects

The unique combination in Excedrin Migraine is specifically formulated to target migraine pain, potentially offering more comprehensive relief for some individuals. However, the best choice can vary depending on individual factors and the specific type of headache.

Using Excedrin Migraine Safely: Tips and Precautions

To maximize the benefits of Excedrin Migraine while minimizing potential risks, it’s important to use the medication safely. What precautions should users take?

1. Adhere to the recommended dosage: Don’t exceed 2 tablets in 24 hours unless directed by a doctor.
2. Be aware of total caffeine intake: Limit other sources of caffeine when taking Excedrin Migraine.
3. Watch for signs of overuse: Frequent use can lead to medication overuse headaches.
4. Consider potential interactions: Consult a healthcare provider if you’re taking other medications.
5. Be mindful of alcohol consumption: Alcohol can increase the risk of stomach bleeding with aspirin use.
6. Monitor for allergic reactions: Discontinue use and seek medical attention if you experience signs of an allergic reaction.
7. Use caution during pregnancy: Consult a doctor before using Excedrin Migraine if pregnant or breastfeeding.

By following these precautions, users can help ensure they’re using Excedrin Migraine safely and effectively.

Understanding Migraine Triggers and Prevention Strategies

While Excedrin Migraine can be effective in treating migraine pain, understanding and managing migraine triggers can be equally important. What are some common migraine triggers and prevention strategies?

Common migraine triggers include:

• Stress
• Hormonal changes
• Certain foods and drinks (e.g., alcohol, caffeine, aged cheeses)
• Changes in sleep patterns
• Environmental factors (e.g., bright lights, loud noises)
• Weather changes

Prevention strategies may include:

1. Keeping a migraine diary to identify personal triggers
2. Practicing stress-reduction techniques like meditation or yoga
3. Maintaining a regular sleep schedule
4. Staying hydrated and eating regular, balanced meals
5. Engaging in regular exercise
6. Limiting known trigger foods and beverages
7. Using preventive medications as prescribed by a healthcare provider

By combining these preventive strategies with appropriate use of medications like Excedrin Migraine, many individuals can achieve better control over their migraine symptoms.

When to Seek Professional Medical Advice

While Excedrin Migraine can be effective for many people, there are situations where professional medical advice is necessary. When should you consult a healthcare provider about your migraines?

• If you experience frequent or severe migraines that significantly impact your quality of life
• If OTC medications like Excedrin Migraine are not providing adequate relief
• If you find yourself using Excedrin Migraine or other pain relievers more than 2-3 times per week
• If you experience new or unusual headache symptoms
• If you have a history of other medical conditions that may be impacted by frequent use of OTC pain relievers
• If you’re pregnant or planning to become pregnant

A healthcare provider can offer a comprehensive evaluation, consider prescription medications if necessary, and help develop a personalized migraine management plan.

In conclusion, Excedrin Migraine, with its combination of caffeine, acetaminophen, and aspirin, offers an effective OTC option for many migraine sufferers. By understanding its caffeine content, proper usage, effectiveness, and potential side effects, users can make informed decisions about incorporating this medication into their migraine management strategy. As with any medication, it’s crucial to use Excedrin Migraine responsibly and in conjunction with other migraine prevention strategies for optimal results.

How much caffeine is in Excedrin Migraine?

Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on Nov 15, 2022.

Each tablet of Excedrin Migraine contains 65 milligrams (mg) of caffeine, 250 mg of acetaminophen, and 250 mg of aspirin. A regular adult dose (2 tablets) contains 130 mg of caffeine, roughly equal to an 8-12 ounce cup of coffee.

How to take Excedrin Migraine

• The regular dosage for adults is 2 tablets with a glass of water.
• Do not take more than two tablets in any 24-hour period, unless directed by a doctor.
• If symptoms worsen or persist, contact your doctor. If you are under 18 years of age, ask a doctor before use.

Excedrin Migraine is an over-the-counter (OTC) medicine approved by the FDA for the relief of migraine pain. In clinical studies, patients with moderate to severe migraines experienced relief with one dose. It can work as quickly as 30 minutes in some people.

The recommended dose of Excedrin Migraine (2 tablets) contains 130 mg of caffeine, which is roughly as much caffeine as found in an 8 ounce cup of coffee. Limit your use of caffeine-containing medications, foods, or beverages while using Excedrin Migraine. Excessive caffeine can cause nervousness, irritability, sleeplessness, and rapid heart beat.

Caffeine has been shown to increase the effects of pain relievers like aspirin and acetaminophen and help to make these medicines more effective in migraine. For some patients, caffeine can trigger a migraine headache, but it has also been shown to be helpful when combined with acetaminophen and aspirin.

How well does Excedrin Migraine work?

In three double-blind, randomized, and placebo-controlled studies with 1220 participants, researchers assessed the effectiveness of the OTC combination of acetaminophen, aspirin, and caffeine in alleviating moderate-to-severe migraine headache pain.

Participants took 2 tablets of the OTC acetaminophen, aspirin, and caffeine or a placebo as a one-time dose for treatment of one migraine attack.

Results showed a significantly greater reduction in migraine pain intensity 1 to 6 hours after the OTC acetaminophen, aspirin, and caffeine dose than placebo in all three studies.

• Pain was reduced to mild or none 2 hours after the dose in over 59% of those taking acetaminophen, aspirin, and caffeine compared to about 33% of placebo-treated patients.
• At 6 hours after the dose, 79% receiving acetaminophen, aspirin, and caffeine had pain reduced to mild or none vs. 52% in the placebo group, and 51% of the drug-treated patients were pain free (with 24% pain-free in the placebo group).
• Symptoms of nausea, photophobia (light sensitivity with pain), phonophobia (sound sensitivity with pain) and functional disability were improved 2 to 6 hours after treatment.

Excedrin Migraine is associated with warnings and side effects, some of which may be severe.

These include:

• Reye’s Syndrome
• risk of allergy
• liver toxicity
• stomach bleeding
• headache rebound due to medication overuse
• caffeine overuse

Review side effects and warnings here (in more detail)

Bottom Line

• Each tablet of Excedrin Migraine contains 65 milligrams (mg) of caffeine, 250 mg of acetaminophen, and 250 mg of aspirin.
• The dosage for adults is 2 tablets with a glass of water. Do not take more than two tablets or geltabs in any 24-hour period, unless directed by a doctor.
• People under 18 years of age should ask a doctor before use.

This is not all the information you need to know about Excedrin Migraine for safe and effective use. Review the full Excedrin Migraine information here, and discuss this information and any questions you have with your doctor or other health care provider.

References

• Lipton RB, et al. Efficacy and Safety of Acetaminophen, Aspirin, and Caffeine in Alleviating Migraine Headache Pain Three Double-blind, Randomized, Placebo-Controlled Trials. Arch Neurol. 1998; 55:210-217. doi:10.1001/archneur.55.2.210
• Excedrin Migraine (label information). DailyMed. US National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7ed841fb-a61c-4868-b4e5-4f2311a5e79c&audience=consumer
• Excedrin Migraine Medication. Excedrin.com. https://www.excedrin.com/products/migraine/
• Excedrin migraine (monograph). Drugs.com. https://www.drugs.com/excedrin-migraine.html

Related medical questions

• How long do caffeine withdrawal headaches last?
• Does caffeine cause high blood pressure?
• Does coffee help with asthma?
• Does caffeine affect Vraylar (cariprazine)?
• Does Maxalt have caffeine in it?
• Does caffeine help migraines?
• Which OTC medications are good for headaches?
• Can you take Excedrin Migraine while pregnant?
• How long does it take for Excedrin Migraine to work?
• Staying Safe while taking Acetaminophen
• Can you take ibuprofen with Excedrin Migraine?

Drug information

• Caffeine
• Excedrin
• Excedrin Migraine

Related support groups

• Caffeine
  (42 questions, 73 members)
• Excedrin
  (24 questions, 45 members)
• Excedrin Migraine
  (15 questions, 17 members)
• Migraine
  (267 questions, 1,609 members)

Medical Disclaimer

If you have migraines, put down your coffee and read this

During medical school, a neurologist taught me that the number one cause of headaches in the US was coffee.

That was news to me! But it made more sense when he clarified that he meant lack of coffee. His point was that for people who regularly drink coffee, missing an early morning cup, or even just having your first cup later than usual, can trigger a caffeine withdrawal headache. And considering how many daily coffee drinkers there are (an estimated 158 million in the US alone), it’s likely that coffee withdrawal is among the most common causes of headaches.

Later in my neurology rotation, I learned that caffeine is a major ingredient in many headache remedies, from over-the-counter medicines such as Excedrin and Anacin, to powerful prescription treatments such as Fioricet. The caffeine is supposed to make the other drugs in these combination remedies (such as acetaminophen or ibuprofen) work better; and, of course, it might be quite effective for caffeine-withdrawal headaches.

But then I learned that for people with migraine headaches, certain drugs, foods, and drinks should be avoided, as they can trigger migraines. At the top of this list? Coffee.

So, to review: the caffeine in coffee, tea, and other foods or drinks can help prevent a headache, treat a headache, and also trigger a headache. How can this be?

Migraine headaches: Still mysterious after all these years

Migraine headaches are quite common: more than a billion people reportedly suffer from migraines worldwide. Yet, the cause has long been a mystery — and it still is.

Until recently, the going theory was that blood vessels around the brain go into spasm, temporarily constricting and limiting blood flow. Then, when the blood vessels open up, the rush of incoming blood flow leads to the actual headache.

That theory has fallen out of favor. Now, the thinking is that migraines are due to waves of electrical activity spreading across the outer portions of the brain, leading to inflammation and overreactive nerve cells that send inappropriate pain signals. Why this begins in the first place is unknown.

Migraines tend to run in families, so genetic factors are likely important. In addition, chemical messengers within the brain, such as serotonin, may also play a central role in the development of migraines, though the mechanisms remain uncertain.

People prone to migraines may experience more headaches after coffee consumption (perhaps by effects on serotonin or brain electrical activity), but coffee itself, or the caffeine it contains, is not considered the actual cause of migraines. Certain foods or drinks like coffee are thought to trigger episodes of migraine, but the true cause is not known.

A new study about coffee and migraines: how much is too much?

In a new study published in the American Journal of Medicine, researchers (including several from the hospital where I work) asked 98 people with migraines to keep a diet diary that included how often they consumed caffeinated beverages (including coffee, tea, carbonated beverages, and energy drinks). This information was compared with how often they had migraines. Here’s what they found:

• The odds of having a migraine increased for those drinking three or more caffeinated beverages per day, but not for those consuming one to two servings per day; the effect lasted through the day after caffeine consumption.
• It seemed to take less caffeine to trigger a headache in those who didn’t usually have much of it. Just one or two servings increased the risk of migraine in those who usually had less than one serving per day.
• The link between caffeine consumption and migraine held up even after accounting for other relevant factors such as alcohol consumption, sleep, and physical activity.

Interestingly, the link was observed regardless of whether the study subject believed that caffeine triggered their headaches.

One weakness of this study is that the researchers did not actually measure caffeine consumption. Instead, they defined one serving of a caffeinated beverage as 8 ounces of regular coffee, 6 ounces of tea, a 12-ounce can of caffeinated soda, or 2 ounces of an energy drink. But caffeine content in different caffeinated beverages can vary widely. For example, an 8-ounce serving of coffee from Starbucks can have twice the caffeine as a similar-sized serving from a Keurig K-Cup. They also did not include caffeine-containing foods in the study, although such amounts tend to be quite small compared with the beverages studied.

The bottom line

There is a lot about the connection between caffeine consumption and migraine headaches that remains uncertain. Until we know more, it seems wise to listen to your body: if you notice more headaches when you drink more coffee (or other caffeinated beverages), cut back. Fortunately, this latest research did not conclude that people with migraines should swear off coffee entirely.

If you like coffee as much as I do, it may seem unfair that you need to keep drinking it to prevent a headache. And if you’re prone to migraines, it might seem unfair that you have to limit your coffee intake to avoid headaches. Either way, you’d be right.

Excedrin film coated tablets No. 20 at a low price in Omsk, instructions for use, composition, analogues

Manufacturer

Bristol-Myers Squibb, USA

Brief description which is designed to relieve migraines.

Excedrine has a triple action: acetylsalicylic acid and paracetamol relieve headaches, while caffeine enhances the effect of the combination.*,** In addition, Excedrine helps to eliminate migraine-related symptoms such as nausea and increased sensitivity to light and sound.*
Excedrin helps relieve pain and other migraine symptoms in 30 minutes!*
* Richard B. Lipton, MD. Walter F. Stewart, PhD, MPH. Robert E. Ryan, Jr, MD. Joel Saper, M.D. Stephen Silberstein, MD. Fred Sheftell, MD. ARCH NEUROL/VOL 55 FEB 1998

caffeine 65 mg

Pharmacological action

Excedrin® is a combined preparation containing paracetamol, acetylsalicylic acid and caffeine.

Paracetamol has an analgesic, antipyretic and extremely weak anti-inflammatory effect, which is associated with its effect on the thermoregulatory center in the hypothalamus and a weak ability to inhibit the synthesis of prostaglandins in peripheral tissues.

Acetylsalicylic acid has analgesic, antipyretic and anti-inflammatory effects. It quickly relieves pain, especially caused by the inflammatory process, and also moderately inhibits platelet aggregation and slows down the process of thrombosis, improving microcirculation in the inflammation site.

Caffeine increases the reflex excitability of the spinal cord, stimulates the respiratory and vasomotor centers, dilates the blood vessels of the skeletal muscles, brain, heart, kidneys, reduces platelet aggregation. Reduces drowsiness, fatigue, increases mental and physical performance.

In this combination, caffeine in a small dose has practically no stimulating effect on the central nervous system, but it helps to normalize the tone of cerebral vessels and accelerate blood flow in it.

Clinical pharmacology

Paracetamol is easily absorbed from the gastrointestinal tract, Cmax in blood plasma are found in the range from 30 minutes to 2 hours after administration. Paracetamol is metabolized in the liver and excreted by the kidneys, mainly in the form of glucuronides and sulfate conjugates. Less than 5% of paracetamol is excreted unchanged.

The duration of T1 / 2 varies from 1 to 4 hours. Communication with plasma proteins is negligible at usual therapeutic doses, however, increases with increasing dose. The hydroxylated metabolite, which is formed in small amounts in the liver under the influence of mixed oxidases and is usually neutralized by binding to glutathione, can accumulate during an overdose of paracetamol and cause liver damage.

Acetylsalicylic acid is rapidly and completely absorbed, undergoes rapid hydrolysis in the gastrointestinal tract, liver and blood to the formation of salicylates, which are further metabolized, mainly in the liver.

Caffeine is completely and rapidly absorbed. Maximum concentrations are observed in the range from 5 to 90 minutes after ingestion on an empty stomach. In adults, excretion occurs almost entirely through hepatic metabolism. There is a marked variability in individual elimination values ​​in adults.

The average T1 / 2 from blood plasma is 4.9 hours in the range of 1.9-12.2 hours. Caffeine is distributed in all body fluids. The relationship of caffeine with plasma proteins is 35%. Caffeine is almost completely metabolized by oxidation, demethylation and acetylation and excreted by the kidneys. Main metabolites: 1-methylxanthine, 7-methylxanthine, 1.7-dimethylxanthine.

Indications

Pain syndrome of moderate and mild intensity of various origins: headache. migraine. toothache. neuralgia. arthralgia and myalgia (pain in the muscles and joints). algodismenorrhea (pain during menstruation).

Use in pregnancy and lactation

Although acetylsalicylic acid can be used in the second trimester of pregnancy, the safety of this combination in pregnant and lactating women has not been studied, therefore the drug is contraindicated in pregnant women (in all trimesters) and breastfeeding.

Contraindications

Hypersensitivity to any of the components of the preparation. erosive and ulcerative lesions of the gastrointestinal tract in the acute phase. gastrointestinal bleeding. complete or incomplete combination of bronchial asthma, recurrent polypnosis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (including history). surgical interventions accompanied by bleeding. hemophilia. hemorrhagic diathesis. hypoprothrombinemia. severe arterial hypertension. portal hypertension. severe course of coronary artery disease. glaucoma. avitaminosis K. renal failure. simultaneous use of other drugs containing paracetamol, acetylsalicylic acid or other non-steroidal anti-inflammatory drug. deficiency of glucose-6-phosphate dehydrogenase. pregnancy. lactation. increased excitability. sleep disorders. children under 15 years of age (risk of developing Reye’s syndrome in children with hyperthermia on the background of viral diseases).

Use with caution in gout, liver disease, headaches associated with head trauma, taking anticoagulants, hypoglycemic agents, gout or arthritis, as well as while taking drugs containing acetylsalicylic acid or other analgesic and antipyretic components.

Side effects

Gastralgia, nausea, vomiting, hepatotoxicity, nephrotoxicity, erosive and ulcerative lesions of the gastrointestinal tract, allergic reactions, tachycardia, increased blood pressure, bronchospasm.

With prolonged use – dizziness, headache, visual disturbances, tinnitus, decreased platelet aggregation, hypocoagulation, hemorrhagic syndrome (nosebleeds, bleeding gums, purpura, etc.), kidney damage with papillary necrosis, deafness, malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome), Reye’s syndrome in children (hyperpyrexia, metabolic acidosis, disorders of the nervous system and psyche, vomiting, abnormal liver function).

Interactions

The drug may enhance the effect of heparin, indirect coagulants, reserpine, steroid hormones and hypoglycemic drugs.
Simultaneous use with other NSAIDs, methotrexate increases the risk of side effects. Reduces the effectiveness of spironolactone, furosemide, antihypertensive drugs, as well as anti-gout drugs that promote the excretion of uric acid.

Barbiturates, rifampicin, salicylamide, antiepileptic drugs and other inducers of microsomal liver enzymes contribute to the formation of toxic metabolites of paracetamol that affect liver function.

Metoclopramide accelerates the absorption of paracetamol. Under the influence of paracetamol, the half-life of chloramphenicol increases by 5 times. When taken repeatedly, paracetamol may enhance the effect of anticoagulants (coumarin derivatives).

Simultaneous use of paracetamol, acetylsalicylic acid and alcoholic beverages increases the risk of hepatotoxic effects. Caffeine accelerates the absorption of ergotamine.

How to take, course of administration and dosage

The drug is taken orally during or after meals.

Adults and adolescents over 15 years: 1 tablet every 4-6 hours.

At the first sign of migraine, take 2 tablets.

The average daily dose is 3-4 tablets per day, the maximum daily dose is 6 tablets per day.

After taking 2 tablets, relief from headaches and other types of pain usually occurs quickly – after 15 minutes, with migraine relief usually occurs after 30 minutes.

In case of pain, the drug should not be taken for more than 5 days without consulting a doctor. For migraine, the drug should not be taken for more than 3 days without consulting a doctor.

Overdose

Symptoms due to the presence of paracetamol (when taken in doses of more than 10-15 g / day): during the first 24 hours, pallor of the skin, nausea, vomiting, anorexia, abdominal pain, impaired glucose metabolism, metabolic acidosis. Symptoms of impaired liver function may appear 12-48 hours after an overdose.

In severe overdose – liver failure with progressive encephalopathy, coma, death. acute renal failure with tubular necrosis (including in the absence of severe liver damage). arrhythmia, pancreatitis. The hepatotoxic effect in adults is manifested when taking 10 g or more.

Symptoms due to the presence of acetylsalicylic acid (when taken in doses of more than 150 mg / kg): with mild intoxication – nausea, vomiting, tinnitus, blurred vision, dizziness, severe headache. In severe poisoning – hyperventilation of the lungs of central origin (shortness of breath, suffocation, cyanosis, cold sticky sweat, respiratory paralysis), respiratory acidosis. The greatest risk of developing chronic intoxication is observed in children and the elderly when taken for several days more than 100 mg / kg / day. In case of moderate and severe poisoning, hospitalization is necessary.

Symptoms due to the presence of caffeine (when taken in doses of more than 300 mg / day): gastralgia, agitation, anxiety, agitation, restlessness, confusion, delirium, dehydration, tachycardia, arrhythmia, hyperthermia, frequent urination, headache, increased tactile or pain sensitivity, tremor or muscle twitching. nausea and vomiting, sometimes with blood. ringing in the ears, epileptic seizures (with acute overdose – tonic-clonic). Treatment: control of acid-base status and electrolyte balance.

Depending on the state of metabolism – the introduction of sodium bicarbonate, sodium citrate or sodium lactate. Increasing alkalinity enhances the excretion of acetylsalicylic acid due to alkalization of urine. Gastric lavage in the first 4 hours, provocation of vomiting, administration of activated charcoal, laxatives, administration of SH-group donors and precursors of the synthesis of glutathione methionine within 8-9 hours after an overdose and acetylcysteine ​​- within 8 hours.

Description

White, oblong film-coated tablets, debossed with E on one side. cross-sectional view – the core is white or almost white.

Special instructions

If after taking the drug the symptoms persist, worsen or new symptoms occur, you should immediately consult a doctor. When taking the drug at the recommended dose, the body receives as much caffeine as is contained in one cup of coffee, therefore, you should reduce the consumption of caffeinated products during treatment with this drug in order to avoid the development of nervous excitement, irritability, insomnia and heart palpitations against the background of an overdose of caffeine.

If an overdose is suspected, medical attention should be sought immediately, even if there are no symptoms. You should refrain from drinking alcohol while taking the drug due to an increased risk of liver damage and gastrointestinal bleeding. Since acetylsalicylic acid slows down blood clotting, the patient who is to undergo surgery should warn the doctor in advance about taking the drug.

Acetylsalicylic acid in low doses reduces the excretion of uric acid, and therefore in patients with a predisposition, the drug can provoke an attack of gout. With prolonged use of the drug, monitoring of peripheral blood and the functional state of the liver is necessary.

Effects on the ability to drive and use machines
No effect on the ability to drive and use machines has been reported.

Presentation

Tablets.

Storage conditions

At temperatures not exceeding 25°C.

Keep out of reach of children.

Shelf life

3 years. Do not use after the expiry date stated on the package.

Active ingredient

Acetylsalicylic acid, Caffeine, Paracetamol

Dosage form

tablets

Indication

For adults, Children over 15 years

Indications

Sciatica, Arthritis, Lumbago, Neuritis, Sciatica, Arthrosis, Colds, Migraine, Influenza, Myositis

Barcode and weight

Barcode: 4607045191784

Weight: 0.040 kg.

Aspirin Free Excedrin – instructions for use, dosage, composition, analogues, side effects / Pillintrip

Page reviewed by pharmacist Kovalenko Svetlana Olegovna ripponHemicranealHistaconMidol Extra StrengthNeo-OptalidonPropain

Drug name

Description Name of the medicine Aspirin Free Excedrin is an automatic translation from the original language.
Do not use this information for any medical prescription or manipulation under any circumstances.
Be sure to read the original instructions for the medicine from the package.
This description may contain numerous errors due to automatic translation!
Keep this in mind and do not use this description!

more…

Aspirin Free Excedrin

Therapeutic indications

Description Therapeutic indications Aspirin Free Excedrin is an automatic translation from the original language.
Do not use this information for any medical prescription or manipulation under any circumstances.
Be sure to read the original instructions for the medicine from the package.
This description may contain numerous errors due to automatic translation!
Keep this in mind and do not use this description!

more. ..

A prescription is a term used to refer to a list of conditions, symptoms, or diseases for which a drug is prescribed or used by a patient. For example, acetaminophen (Excedrine without aspirin) or paracetamol is used by a patient for a fever, or a doctor prescribes it for a headache or body aches. Now fever, headache and body aches are signs of paracetamol. The patient should be aware of the indications for drugs used in common conditions because they can be taken without a prescription from a pharmacy.

Headache, migraine, fever, toothache, cold pain

Acetaminophen (Excedrin without aspirin) is an analgesic and antipyretic.

Caffeine (Excedrine Without Aspirin) is used in this product to enhance the analgesic effect of Acetaminophen (Aspirin Without Excedrine).

Acetaminophen (Excedrine without Aspirin) and caffeine (Excedrine without Aspirin) is a combination medicine used to treat many conditions such as headache or muscle pain.

Acetaminophen (Excedrine without aspirin) and caffeine (Excedrine without aspirin) may also be used for purposes not listed in this medication guide.

Dosage and Administration

Description Dosage and Administration Aspirin Free Excedrin is an automatic translation from the original language.
Do not use this information for any medical prescription or manipulation under any circumstances.
Be sure to read the original instructions for the medicine from the package.
This description may contain numerous errors due to automatic translation!
Keep this in mind and do not use this description!

more…

Usual Adult Dose for Common Cold Symptoms:

12 years and older:

Starting Dose: Caffeine (Excedrine without aspirin) 130 mg spirin) 1000 mg orally every 6 hours as needed

Maximum dose: Caffeine (Excedrine without aspirin) 520 mg-Acetaminophen (Excedrine without aspirin) 4000 mg orally over 24 hours

Use: For temporary relief of minor pain from headache, sinusitis, colds, muscle pain, menstrual discomfort, toothache and arthritis.

Usual Adult Dose for Dysmenorrhea:

12 years and older:

Starting Dose: Caffeine (Excedrin without aspirin) 130 mg-Acetaminophen (Excedrin without aspirin) 1000 mg orally every 6 hours as needed

Maximum dose : Caffeine (Excedrine without Aspirin) 520mg-Acetaminophen (Excedrine without Aspirin) 4000mg orally for 24 hours .

Usual Adult Dose for Osteoarthritis:

12 years and older:

Starting Dose: Caffeine (Excedrin without aspirin) 130 mg-Acetaminophen (Excedrin without aspirin) 1000 mg orally every 6 hours as needed

Maximum dose : Caffeine (Excedrine without Aspirin) 520mg-Acetaminophen (Excedrine without Aspirin) 4000mg orally for 24 hours .

Usual Adult Dose for Pain Relief:

12 years and older:

Starting Dose: Caffeine (Excedrin without aspirin) 130 mg-Acetaminophen (Excedrin without aspirin) 1000 mg orally every 6 hours as needed necessary

Maximum dose : Caffeine (Excedrine without Aspirin) 520mg-Acetaminophen (Excedrine without Aspirin) 4000mg orally for 24 hours .

Usual Adult Dose for Sinusitis:

12 years and older:

Starting Dose: Caffeine (Excedrin without aspirin) 130 mg-Acetaminophen (Excedrin without aspirin) 1000 mg orally every 6 hours as needed

Maximum dose : Caffeine (Excedrine without Aspirin) 520mg-Acetaminophen (Excedrine without Aspirin) 4000mg orally for 24 hours .

Usual Adult Dose for Headache:

12 years and older:

Starting Dose: Caffeine (Excedrin without aspirin) 130 mg-Acetaminophen (Excedrin without aspirin) 1000 mg orally every 6 hours for as required

Maximum dose: Caffeine (Excedrin without Aspirin) 520 mg-Acetaminophen (Excedrin without Aspirin) 4000 mg orally for 24 hours arthritis.

Contraindications

Description Contraindications Aspirin Free Excedrin is an automatic translation from the original language.
Do not use this information for any medical prescription or manipulation under any circumstances.
Be sure to read the original instructions for the medicine from the package.
This description may contain numerous errors due to automatic translation!
Keep this in mind and do not use this description!

more…

See also:
What is the most important information I should know about Excedrine without aspirin?

OTC Labeling: If using for self-medication, do not use other medicines that contain Acetaminophen (Excedrine without Aspirin) or if you are allergic to Acetaminophen (Excedrine without Aspirin), aspirin, or any other pain medication.

Special Warnings and Precautions

Description Special Warnings and Precautions Aspirin Free Excedrin is an automatic translation from the original language.
Do not use this information for any medical prescription or manipulation under any circumstances.
Be sure to read the original instructions for the medicine from the package.
This description may contain numerous errors due to automatic translation!
Keep this in mind and do not use this description!

more…

Use Acetaminophen (Excedrine without Aspirin)/Caffeine (Excedrine without Aspirin) as directed by your doctor. Check the medication label for exact dosing instructions.

• Acetaminophen (Excedrine without Aspirin)/Caffeine (Excedrine without Aspirin) may be taken with or without food.
• If you miss a dose of acetaminophen (Excedrine without aspirin)/caffeine (Excedrine without aspirin) and are using it regularly, take it as soon as possible. If it’s almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your doctor any questions you have about how to use Acetaminophen (Excedrine without aspirin)/Caffeine (Excedrine without aspirin).

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after a few days, some drugs need to be continued for an extended period to get the benefit from it.

Use: Labeled indications

Pain: For the temporary relief of pain caused by headache or muscle pain

Interactions with other drugs

Description Interactions with other drugs Aspirin Free Excedrin is automatic translation from the original language.
Do not use this information for any medical prescription or manipulation under any circumstances.
Be sure to read the original instructions for the medicine from the package.
This description may contain numerous errors due to automatic translation!
Keep this in mind and do not use this description!

more…

See also:
What other drugs will affect Excedrin Aspirin Free?

Acetaminophen (Excedrine without aspirin) is metabolized (excreted into other chemicals) by the liver. Therefore, drugs that increase the action of liver enzymes that metabolize Acetaminophen (Aspirin-free Excedrin) [eg, carbamazepine (Tegretol), isoniazid (INC, Nidrazide, Laniazid), rifampicin (Rifamat, Rifadin, Rimactan)] reduce levels of Acetaminophen (Aspirin-free Excedrin) and may reduce the effect of Acetaminophen (Aspirin free Excedrin).). Doses of acetaminophen (Excedrine without aspirin) in excess of the recommended doses are toxic to the liver and can lead to severe liver damage. The ability of acetaminophen (Excedrine without aspirin) to harm the liver is increased when it is combined with alcohol or drugs that also harm the liver.

Cholestyramine (Questran) reduces the effects of acetaminophen (Excedrine without aspirin) by reducing its absorption into the body from the intestines. Therefore, acetaminophen (Excedrin without aspirin) should be administered 3-4 hours after cholestyramine or one hour before cholestyramine.

Acetaminophen (Excedrin without aspirin) at doses greater than 2275 mg per day may increase the blood-thinning effect of warfarin (Coumadin) by an unknown mechanism. Therefore, long-term or high doses of acetaminophen (Excedrine without aspirin) should be avoided during warfarin therapy.

Side effects

Description Side effects Aspirin Free Excedrin is an automatic translation from the original language.
Do not use this information for any medical prescription or manipulation under any circumstances.
Be sure to read the original instructions for the medicine from the package.
This description may contain numerous errors due to automatic translation!
Keep this in mind and do not use this description!

more…

See also:
What are the possible side effects of Excedrin without aspirin?

Used Paracetamol (Aspirin free Excedrin)/caffeine (Aspirin free Excedrin): oral tablets, tablets disintegrate

Get emergency medical help if you have any of these signs of an allergic reaction while taking acetaminophen (Excedrin without aspirin) / caffeine (Excedrine without aspirin): hives, difficulty breathing, swelling of the face, lips, tongue or throat.

Rarely, acetaminophen (Excedrine without aspirin) can cause a severe skin reaction that can be fatal. This can happen even if you have taken Acetaminophen (Excedrin without aspirin) in the past and have not had any reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blisters and peeling. If you have this type of reaction, you should never take any medicine containing acetaminophen (Excedrin without aspirin) again.

Stop using acetaminophen (Excedrin without aspirin) and caffeine (Excedrin without aspirin) and call your doctor immediately if you have:

• low fever with nausea, abdominal pain and loss of appetite, dark urine , clay-colored stools or

• jaundice (yellowing of the skin or eyes).

Common side effects may include:

• trouble sleeping (insomnia), or

• feeling nervous, irritable or nervous.

This is not a complete list of side effects and others may occur. See your doctor for medical advice about side effects.

Overdose

Description Overdose Aspirin Free Excedrin is an automatic translation from the original language.
Do not use this information for any medical prescription or manipulation under any circumstances.
Be sure to read the original instructions for the medicine from the package.
This description may contain numerous errors due to automatic translation!
Keep this in mind and do not use this description!

more…

Composition

Description Composition Aspirin Free Excedrin is an automatic translation from the original language.
Do not use this information for any medical prescription or manipulation under any circumstances.
Be sure to read the original instructions for the medicine from the package.
This description may contain numerous errors due to automatic translation!
Keep this in mind and do not use this description!

more.