Does meloxicam cause constipation? What are the common, mild, and serious side effects of this medication? Get in-depth insights on managing meloxicam side effects.

Understanding Meloxicam (Mobic) and Its Side Effects

Meloxicam, marketed under the brand name Mobic, is a generic prescription medication used to treat osteoarthritis, rheumatoid arthritis (RA), and juvenile RA. As with any medication, meloxicam can cause a range of side effects, some of which are more common than others. In this comprehensive guide, we will delve into the potential side effects of meloxicam, including how to manage them.

Common Side Effects of Meloxicam

According to clinical trials, some of the more common side effects reported by people taking meloxicam include:

• Upper respiratory infections, such as the common cold
• Flu-like symptoms, including fever, chills, or sore throat
• Digestive problems, such as abdominal pain, constipation, and diarrhea
• Headaches

Mild Side Effects of Meloxicam

In addition to the common side effects, meloxicam use may also result in mild side effects, such as:

• Mild infections, including urinary tract infections (UTIs) and upper respiratory infections
• Flu-like symptoms, including fever, chills, or sore throat
• Dizziness
• Back pain
• Insomnia
• Rash or itchiness
• Sleepiness or drowsiness
• Digestive problems, such as abdominal pain, constipation, and diarrhea
• Weight gain or weight loss
• Headaches
• Joint pain
• Mild allergic reactions

It’s important to note that these side effects may be temporary, lasting a few days to weeks. However, if the side effects persist, bother you, or become severe, it’s essential to consult your doctor or pharmacist.

Serious Side Effects of Meloxicam

Meloxicam may also cause serious side effects, which can include:

• Anemia (low level of red blood cells), with symptoms such as lightheadedness, pale-looking skin, and shortness of breath
• High blood potassium level, with symptoms like nausea, vomiting, shortness of breath, muscle cramps, and heart palpitations
• Severe skin reactions, such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug rash with eosinophilia and systemic symptoms, with symptoms like fever, swollen lymph nodes, painful rash, and blisters or peeling skin around the eyes, mouth, or throat
• Fluid buildup, which may occur in the face, arms, or legs, with symptoms like weight gain, shiny or stretched skin, and pain or stiffness around the affected area
• Kidney damage, with symptoms like fatigue, nausea, vomiting, loss of appetite, and muscle cramps
• Liver damage, with symptoms like fatigue, nausea, diarrhea, pain in the upper right abdomen, and jaundice
• High blood pressure, which doesn’t typically cause symptoms
• Heart problems
• Digestive system problems
• Severe allergic reaction

If you experience any of these serious side effects, it’s crucial to contact your doctor immediately or seek emergency medical attention.

Meloxicam Side Effects in Children

Meloxicam is approved for use in children weighing at least 60 kilograms (132 pounds) to treat juvenile rheumatoid arthritis. While most side effects are expected to be the same as in adults, some side effects may be more common in children, such as:

• Certain digestive problems, such as diarrhea, vomiting, and abdominal pain
• Fever
• Headache

Managing Meloxicam Side Effects

If you experience any side effects while taking meloxicam, it’s important to talk to your doctor or pharmacist. They can provide guidance on how to manage the side effects, which may include adjusting the dosage or switching to a different medication if necessary.

In the meantime, here are some tips that may help alleviate certain side effects:

• For digestive issues like constipation, try increasing your fiber intake and staying hydrated.
• For headaches, try over-the-counter pain relievers like acetaminophen or ibuprofen.
• For sleep disturbances, practice good sleep hygiene, such as sticking to a consistent sleep schedule and creating a relaxing bedtime routine.
• For rashes or itchiness, use a gentle, fragrance-free moisturizer and avoid irritants.

If the side effects persist or worsen, it’s crucial to contact your healthcare provider right away. They can help determine the best course of action to manage your symptoms and ensure your safety.

Conclusion

Meloxicam, while generally well-tolerated, can cause a range of side effects, from mild to serious. By understanding the potential side effects and how to manage them, you can work closely with your healthcare provider to ensure the safe and effective use of this medication. Remember to report any side effects to your doctor or the FDA, as this helps improve the overall understanding and management of meloxicam’s safety profile.

Meloxicam oral tablet side effects: How to manage

Meloxicam (Mobic, Anjeso) is a generic prescription medication. Meloxicam comes as an oral tablet and oral capsule. Both forms of meloxicam are used to treat osteoarthritis. In addition, meloxicam oral tablet is used to treat rheumatoid arthritis (RA) and juvenile RA.

Meloxicam may be used as a short-term or long-term treatment. As with other drugs, meloxicam can cause side effects.

This article focuses on just the oral tablet form of meloxicam, which is available as the brand-name drug Mobic. Read on to learn about its potential common, mild, and serious side effects. For a general overview of meloxicam, including details about its uses, refer to this article. Your doctor can also tell you more about meloxicam.

Meloxicam can cause certain side effects, some of which are more common than others. These side effects may be temporary, lasting a few days to weeks. However, if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist.

These are just a few of the more common side effects reported by people who took meloxicam in clinical trials:

• upper respiratory infection, such as the common cold
• flu-like symptoms, such as fever, chills, or sore throat
• digestive problems, such as abdominal pain, constipation, and diarrhea
• headache*

* For more information about this side effect, see “Side effect specifics” below.

Mild side effects can occur with meloxicam use. This list doesn’t include all possible mild side effects of the drug. For more information, you can refer to meloxicam’s prescribing information.

Mild side effects that have been reported with meloxicam include:

• mild infections, including urinary tract infection (UTI) and upper respiratory infection, such as the common cold
• flu-like symptoms, such as fever, chills, or sore throat
• dizziness
• back pain
• insomnia
• rash or itchiness
• sleepiness or drowsiness
• digestive problems, such as abdominal pain, constipation, and diarrhea
• weight gain or weight loss*
• headache*
• joint pain*
• mild allergic reaction*

These side effects may be temporary, lasting a few days to weeks. However, if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist.

Note: After the Food and Drug Administration (FDA) approves a drug, it tracks side effects of the medication. If you develop a side effect while taking meloxicam and want to tell the FDA about it, visit MedWatch.

* For more information about this side effect, see “Side effect specifics” below.

Meloxicam may cause serious side effects. The list below may not include all possible serious side effects of the drug. For more information, you can refer to meloxicam’s prescribing information.

If you develop serious side effects while taking meloxicam, call your doctor right away. If the side effects seem life threatening or you think you’re having a medical emergency, immediately call 911 or your local emergency number.

Serious side effects that have been reported and their symptoms include:

• Anemia (low level of red blood cells). Symptoms can include:
  • lightheadedness
  • pale-looking skin
  • shortness of breath
• High blood potassium level. Symptoms can include:
  • nausea and vomiting
  • shortness of breath
  • muscle cramps
  • heart palpitations
• Severe skin reactions, such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug rash with eosinophilia and systemic symptoms. Symptoms can include:
  • fever
  • swollen lymph nodes
  • painful rash
  • blisters or peeling skin around the eyes, mouth, or throat
• Fluid buildup, which may occur in the face, arms, or legs. Symptoms can include:
  • weight gain
  • shiny, stretched, or swollen skin around the affected area
  • pain or stiffness around the affected area
• Kidney damage. Symptoms can include:
  • fatigue
  • nausea and vomiting
  • loss of appetite
  • muscle cramps
• Liver damage. Symptoms can include:
  • fatigue
  • nausea
  • diarrhea
  • pain in the upper right abdomen
  • jaundice
• High blood pressure, which doesn’t typically cause symptoms.
• Heart problems.*
• Digestive system problems.*
• Severe allergic reaction.

* Meloxicam has a boxed warning for this side effect. This is the most serious warning from the Food and Drug Administration (FDA). To learn more, see the “Side effect specifics” section below.

Meloxicam is approved to treat juvenile rheumatoid arthritis in children weighing at least 60 kilograms (kg), which is about 132 pounds (lb). (1 kg is about 2.2 lb.)

Most side effects of meloxicam in children are expected to be the same as those in adults. For details, see the “Meloxicam: Mild side effects” and “Meloxicam: Serious side effects” sections above.

However, the following side effects may be more common in children than in adults:

• certain digestive problems, such as diarrhea, vomiting, and abdominal pain
• fever
• headache

If you have questions about how meloxicam may affect your child, talk with their doctor.

Learn more about some of the side effects that meloxicam may cause. To find out how often side effects occurred in clinical trials, see the prescribing information for meloxicam.

Heart problems

Meloxicam has a boxed warning about the risk of heart problems. A boxed warning is a serious warning from the Food and Drug Administration (FDA). It alerts doctors and patients about drug effects that may be dangerous.

Taking meloxicam can increase the risk of certain heart problems, including heart attack and stroke. Heart attack was a rare side effect in clinical trials of meloxicam, and stroke was not reported as a side effect in the clinical trials. However, nonsteroidal anti-inflammatory drugs such as meloxicam can increase this risk.

Symptoms of a heart attack can include tightness, pressure, or pain in your chest that spreads to your jaw, neck, back, or arms. Symptoms of a stroke may include headache, weakness on one side of your body, and trouble walking, seeing, or speaking.

Several factors can increase your risk of heart problems with meloxicam. These include:

• taking high doses of the drug
• having heart problems or risk factors for heart problems, such as high blood pressure, high cholesterol, and smoking
• having had a recent heart attack or a certain heart surgery
• being an older adult (age 65 years and over)

Due to the risk of heart problems, your doctor will prescribe the lowest dose of meloxicam that’s effective for treating your condition. And they’ll prescribe this dosage for the shortest amount of time needed to treat your condition.

What you can do

Before taking meloxicam, be sure your doctor knows if you have heart problems or risk factors for heart problems. Also, tell them if you have a history of heart failure or if you’ve recently had a heart attack or heart surgery. They’ll likely prescribe a drug other than meloxicam to treat your condition.

If you have symptoms of heart attack or stroke while taking meloxicam, immediately call 911 or your local emergency number.

Digestive system problems

Meloxicam has a boxed warning about the risk of digestive system problems. A boxed warning is a serious warning from the FDA. It alerts doctors and patients about drug effects that may be dangerous.

Taking meloxicam can increase the risk of inflammation, bleeding, ulcers (sores), or perforations (tears) in your digestive system. (The digestive system includes your esophagus, stomach, small intestine, and large intestine.) These side effects were rare in clinical trials of meloxicam. However, they can be fatal.

Symptoms of digestive system problems can include bloody stool, nausea and vomiting, and abdominal or stomach pain.

Several factors can increase your risk of digestive system problems with meloxicam. These include:

• taking meloxicam long term
• having had ulcers or bleeding in your digestive system in the past
• having conditions that increase your risk of bleeding, such as hemophilia
• having severe liver problems, such as liver failure
• drinking alcohol or smoking
• being an older adult (age 65 years and over) or having other health conditions
• taking other medications that increase the risk of digestive system problems, including:
  • corticosteroids such as prednisone (Rayos)
  • blood thinners such as warfarin (Jantoven)
  • selective serotonin reuptake inhibitors such as sertraline (Zoloft) or citalopram (Celexa)
  • other nonsteroidal anti-inflammatory drugs such as aspirin or ibuprofen (Advil, Motrin)

What you can do

Before taking meloxicam, tell your doctor if you have any of the factors listed above that may increase your risk of digestive system problems. They’ll recommend whether it’s safe for you to take meloxicam.

If you have symptoms of digestive system problems while taking meloxicam, contact your doctor right away. However, if your symptoms feel severe or life threatening, immediately call 911 or your local emergency number.

Weight gain or weight loss

Weight gain or weight loss can occur with meloxicam. However, weight changes were rare in clinical trials of the drug.

Keep in mind that meloxicam may cause fluid buildup in the face, arms, or legs. And fluid buildup may cause weight gain for some people.

What you can do

If you’re concerned about weight changes while taking meloxicam, talk with your doctor. They can advise you on your risk of weight gain or weight loss. Your doctor can also recommend ways to maintain a weight that’s healthy for you.

Headache

Meloxicam may cause headache. This was one of the most common side effects in clinical trials of the drug.

With headache, you may have pain on one or both sides of your head. This pain may come on suddenly or gradually, and it may last for several hours.

It’s important to remember that headache can be a symptom of stroke. Meloxicam has a boxed warning about the risk of heart problems, including stroke. For details, see “Heart problems” above.

What you can do

If you have a headache with meloxicam that’s bothersome or long lasting, talk with your doctor. They can recommend ways to ease this side effect.

Keep in mind that meloxicam belongs to a drug class called nonsteroidal anti-inflammatory drugs (NSAIDs). Certain NSAIDs are available without a prescription and may be used to relieve pain, including headache pain. Examples include ibuprofen (Advil, Motrin) and naproxen (Aleve).

However, your doctor will likely recommend that you avoid taking other NSAIDs with meloxicam. This is because taking meloxicam with other NSAIDs can increase your risk of digestive system problems. Meloxicam has a boxed warning about this risk. For details, see “Digestive system problems” above.

Joint pain

Joint pain may occur with meloxicam. This was a less common side effect in clinical trials of the drug.

With joint pain, you may have swelling, stiffness, or tenderness in the affected joint.

Remember that meloxicam is used to treat conditions that cause joint pain. These include osteoarthritis (OA) and rheumatoid arthritis (RA). So it’s possible that joint pain with meloxicam may be related to OA or RA rather than the drug itself.

What you can do

If you have joint pain with meloxicam, talk with your doctor. They can help you determine whether the joint pain may be related to meloxicam or the condition the drug is treating. Your doctor can recommend ways to manage this side effect.

It’s important to remember that meloxicam should not be taken with other nonsteroidal anti-inflammatory drugs (NSAIDs). (NSAID is the drug class that meloxicam belongs to.) Certain NSAIDs are available without a prescription and may be used to relieve pain, including joint pain. Examples include ibuprofen (Advil, Motrin) and naproxen (Aleve).

However, your doctor will likely recommend that you avoid taking other NSAIDs with meloxicam. This is because taking meloxicam with other NSAIDs can increase your risk of digestive system problems. Meloxicam has a boxed warning about this risk. For details, see “Digestive system problems” above.

Allergic reaction

As with most drugs, meloxicam can cause an allergic reaction in some people. However, this side effect was rare in clinical trials.

Symptoms can be mild or serious and can include:

• skin rash
• itching
• flushing
• swelling under your skin, typically in your eyelids, lips, hands, or feet
• swelling of your mouth, tongue, or throat, which can make it hard to breathe

What you can do

For mild symptoms of an allergic reaction, call your doctor right away. They may recommend ways to ease your symptoms and determine whether you should keep taking meloxicam. However, if your symptoms are serious and you think you’re having a medical emergency, immediately call 911 or your local emergency number.

Meloxicam may cause several side effects. Here are some frequently asked questions about the drug’s side effects and their answers.

Are side effects of meloxicam the same with 7.5-mg and the 15-mg tablets?

Yes, the side effects of meloxicam are expected to be the same regardless of the strength you take. In clinical trials, similar side effects were reported for the 7.5-milligram (mg) and 15-mg strengths.

However, your risk of certain side effects may be greater at higher doses of meloxicam. For example, taking higher doses of meloxicam may increase your risk of heart problems* as a side effect.

To learn more about what to expect with the 7.5-mg and 15-mg tablets of meloxicam, talk with your doctor.

* Meloxicam has a boxed warning for this side effect. This is the most serious warning from the Food and Drug Administration (FDA). To learn more, see the “Side effect specifics” section above.

Do meloxicam’s side effects vary between adults and children?

Not necessarily. The side effects of meloxicam are expected to be the same in adults and children. For details about specific side effects that may occur, see the “Meloxicam: Mild side effects” and “Meloxicam: Serious side effects” sections above.

However, certain side effects may be more common in children than in adults. To learn more about meloxicam’s side effects in children, see the “Meloxicam: Side effects in children” section above.

Is tingling a side effect of taking meloxicam?

It’s possible. Paresthesia was a rare side effect in clinical trials of meloxicam. With paresthesia, you may have tingling, numbness, or burning in your arms, hands, legs, or feet.

If you have bothersome symptoms of paresthesia while taking meloxicam, talk with your doctor. They can recommend ways to manage this side effect. For example, your doctor may switch you to a treatment other than meloxicam that isn’t known to cause this side effect.

Meloxicam may cause hair loss. This side effect was rare in clinical trials of the drug.

Keep in mind that meloxicam is used to treat rheumatoid arthritis (RA), which may also cause hair loss. If you’re taking meloxicam to treat RA, you may have hair loss related to your condition.

If you’re concerned about hair loss with meloxicam, talk with your doctor. They can discuss your risk of this side effect. And they can suggest ways to manage hair loss if it happens.

In older adults (ages 65 years and over), the side effects of meloxicam are expected to be the same as for younger adults. For details about specific side effects that may occur, see the “Meloxicam: Mild side effects” and “Meloxicam: Serious side effects” sections above.

However, older adults may have an increased risk of certain side effects when compared with younger adults. Examples of these side effects can include:

• kidney damage
• heart problems*
• digestive system problems*

Due to these risks, doctors may prescribe a lower dosage of meloxicam for older adults. For details about meloxicam’s dosage, see this article.

If you have questions about meloxicam’s side effects in older adults, talk with your doctor or pharmacist.

* Meloxicam has a boxed warning for this side effect. This is the most serious warning from the Food and Drug Administration (FDA). To learn more, see the “Side effect specifics” section above.

Meloxicam comes with several precautions that may determine whether you can safely take the medication. Keep reading to learn more.

Boxed warnings

This drug has boxed warnings about risks of heart problems and digestive system problems. These are serious warnings from the Food and Drug Administration (FDA). For details, see the “Side effect specifics” section above.

Other precautions

Be sure to talk with your doctor about your health history before you take meloxicam. This drug may not be the right treatment option for you if you have certain medical conditions or other factors that affect your health. These are known as drug-condition or drug-factor interactions. The conditions and factors to consider include:

Asthma. Meloxicam may worsen asthma in certain people with this condition. This risk is especially high in people who have asthma that has worsened in the past after taking aspirin or another nonsteroidal anti-inflammatory drug (NSAID). (NSAID is the drug class meloxicam belongs to.) Your doctor can recommend whether it’s safe for you to take meloxicam.

Heart failure. Meloxicam can worsen heart failure in people who already have this condition. Due to this risk, your doctor may not prescribe meloxicam for you if you have heart failure.

High blood pressure. Meloxicam may cause high blood pressure. Be sure to tell your doctor if you already have high blood pressure or take medications for this condition. Meloxicam could increase your blood pressure further, which could make blood pressure medications less effective. If you take meloxicam, your doctor may watch your blood pressure more closely than is typical during treatment.

Kidney or liver problems. Before taking meloxicam, tell your doctor if you have kidney or liver problems. Examples include kidney or liver failure. Meloxicam may worsen your condition. Your doctor can tell you whether it’s safe to take meloxicam while you have kidney or liver problems. In some cases, they may prescribe meloxicam at a lower dosage. Or they may prescribe a drug other than meloxicam for you.

Allergic reaction. If you’ve had an allergic reaction to meloxicam or any of its ingredients, your doctor will likely not prescribe meloxicam. Taking meloxicam could cause you to have another allergic reaction. Ask your doctor what other medications may be better options for you.

Alcohol with meloxicam

You should not take meloxicam with alcohol. Doing so could increase your risk of digestive system problems with the drug. Meloxicam has a boxed warning for this side effect. This is the most serious warning from the FDA. To learn more, see the “Side effect specifics” section above.

If you have questions about alcohol and meloxicam, talk with your doctor.

Pregnancy and breastfeeding while taking meloxicam

Below is important information about taking meloxicam while pregnant or breastfeeding.

Pregnancy

It may not be safe to take meloxicam during pregnancy, especially between week 30 of pregnancy and birth. Doing so may cause certain heart and kidney problems in a fetus.

In certain cases, your doctor may tell you it’s safe to take meloxicam before week 30 of pregnancy. If so, they’ll prescribe meloxicam at the lowest dosage and for the shortest amount of time needed to treat your condition.

If you’re pregnant or planning to become pregnant, talk with your doctor before taking meloxicam.

Breastfeeding

It’s not known whether meloxicam is safe to take while breastfeeding. It’s not known whether the drug passes into breast milk or what effects it may have on a child who is breastfed.

If you’re breastfeeding or planning to do so, talk with your doctor before taking meloxicam. They can talk with you about the risks and benefits of breastfeeding while taking the drug.

Meloxicam may cause mild and serious side effects. If you have bothersome or long lasting side effects with meloxicam, talk with your doctor or pharmacist.

If you’d like to learn more about meloxicam, talk with your doctor or pharmacist. They can help answer any questions you have about side effects of taking the drug. Referring to the following articles about meloxicam can provide you with additional information:

• More information about meloxicam. For details about other aspects of meloxicam, refer to this article. You can also view this article about meloxicam and liver damage.
• A look at your condition. For details about arthritis, see our arthritis hub. To learn about rheumatoid arthritis, view our rheumatoid arthritis hub.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

Meloxicam oral tablet side effects: How to manage

Meloxicam (Mobic, Anjeso) is a generic prescription medication. Meloxicam comes as an oral tablet and oral capsule. Both forms of meloxicam are used to treat osteoarthritis. In addition, meloxicam oral tablet is used to treat rheumatoid arthritis (RA) and juvenile RA.

Meloxicam may be used as a short-term or long-term treatment. As with other drugs, meloxicam can cause side effects.

This article focuses on just the oral tablet form of meloxicam, which is available as the brand-name drug Mobic. Read on to learn about its potential common, mild, and serious side effects. For a general overview of meloxicam, including details about its uses, refer to this article. Your doctor can also tell you more about meloxicam.

Meloxicam can cause certain side effects, some of which are more common than others. These side effects may be temporary, lasting a few days to weeks. However, if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist.

These are just a few of the more common side effects reported by people who took meloxicam in clinical trials:

• upper respiratory infection, such as the common cold
• flu-like symptoms, such as fever, chills, or sore throat
• digestive problems, such as abdominal pain, constipation, and diarrhea
• headache*

* For more information about this side effect, see “Side effect specifics” below.

Mild side effects can occur with meloxicam use. This list doesn’t include all possible mild side effects of the drug. For more information, you can refer to meloxicam’s prescribing information.

Mild side effects that have been reported with meloxicam include:

• mild infections, including urinary tract infection (UTI) and upper respiratory infection, such as the common cold
• flu-like symptoms, such as fever, chills, or sore throat
• dizziness
• back pain
• insomnia
• rash or itchiness
• sleepiness or drowsiness
• digestive problems, such as abdominal pain, constipation, and diarrhea
• weight gain or weight loss*
• headache*
• joint pain*
• mild allergic reaction*

These side effects may be temporary, lasting a few days to weeks. However, if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist.

Note: After the Food and Drug Administration (FDA) approves a drug, it tracks side effects of the medication. If you develop a side effect while taking meloxicam and want to tell the FDA about it, visit MedWatch.

* For more information about this side effect, see “Side effect specifics” below.

Meloxicam may cause serious side effects. The list below may not include all possible serious side effects of the drug. For more information, you can refer to meloxicam’s prescribing information.

If you develop serious side effects while taking meloxicam, call your doctor right away. If the side effects seem life threatening or you think you’re having a medical emergency, immediately call 911 or your local emergency number.

Serious side effects that have been reported and their symptoms include:

• Anemia (low level of red blood cells). Symptoms can include:
  • lightheadedness
  • pale-looking skin
  • shortness of breath
• High blood potassium level. Symptoms can include:
  • nausea and vomiting
  • shortness of breath
  • muscle cramps
  • heart palpitations
• Severe skin reactions, such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug rash with eosinophilia and systemic symptoms. Symptoms can include:
  • fever
  • swollen lymph nodes
  • painful rash
  • blisters or peeling skin around the eyes, mouth, or throat
• Fluid buildup, which may occur in the face, arms, or legs. Symptoms can include:
  • weight gain
  • shiny, stretched, or swollen skin around the affected area
  • pain or stiffness around the affected area
• Kidney damage. Symptoms can include:
  • fatigue
  • nausea and vomiting
  • loss of appetite
  • muscle cramps
• Liver damage. Symptoms can include:
  • fatigue
  • nausea
  • diarrhea
  • pain in the upper right abdomen
  • jaundice
• High blood pressure, which doesn’t typically cause symptoms.
• Heart problems.*
• Digestive system problems.*
• Severe allergic reaction.

* Meloxicam has a boxed warning for this side effect. This is the most serious warning from the Food and Drug Administration (FDA). To learn more, see the “Side effect specifics” section below.

Meloxicam is approved to treat juvenile rheumatoid arthritis in children weighing at least 60 kilograms (kg), which is about 132 pounds (lb). (1 kg is about 2.2 lb.)

Most side effects of meloxicam in children are expected to be the same as those in adults. For details, see the “Meloxicam: Mild side effects” and “Meloxicam: Serious side effects” sections above.

However, the following side effects may be more common in children than in adults:

• certain digestive problems, such as diarrhea, vomiting, and abdominal pain
• fever
• headache

If you have questions about how meloxicam may affect your child, talk with their doctor.

Learn more about some of the side effects that meloxicam may cause. To find out how often side effects occurred in clinical trials, see the prescribing information for meloxicam.

Heart problems

Meloxicam has a boxed warning about the risk of heart problems. A boxed warning is a serious warning from the Food and Drug Administration (FDA). It alerts doctors and patients about drug effects that may be dangerous.

Taking meloxicam can increase the risk of certain heart problems, including heart attack and stroke. Heart attack was a rare side effect in clinical trials of meloxicam, and stroke was not reported as a side effect in the clinical trials. However, nonsteroidal anti-inflammatory drugs such as meloxicam can increase this risk.

Symptoms of a heart attack can include tightness, pressure, or pain in your chest that spreads to your jaw, neck, back, or arms. Symptoms of a stroke may include headache, weakness on one side of your body, and trouble walking, seeing, or speaking.

Several factors can increase your risk of heart problems with meloxicam. These include:

• taking high doses of the drug
• having heart problems or risk factors for heart problems, such as high blood pressure, high cholesterol, and smoking
• having had a recent heart attack or a certain heart surgery
• being an older adult (age 65 years and over)

Due to the risk of heart problems, your doctor will prescribe the lowest dose of meloxicam that’s effective for treating your condition. And they’ll prescribe this dosage for the shortest amount of time needed to treat your condition.

What you can do

Before taking meloxicam, be sure your doctor knows if you have heart problems or risk factors for heart problems. Also, tell them if you have a history of heart failure or if you’ve recently had a heart attack or heart surgery. They’ll likely prescribe a drug other than meloxicam to treat your condition.

If you have symptoms of heart attack or stroke while taking meloxicam, immediately call 911 or your local emergency number.

Digestive system problems

Meloxicam has a boxed warning about the risk of digestive system problems. A boxed warning is a serious warning from the FDA. It alerts doctors and patients about drug effects that may be dangerous.

Taking meloxicam can increase the risk of inflammation, bleeding, ulcers (sores), or perforations (tears) in your digestive system. (The digestive system includes your esophagus, stomach, small intestine, and large intestine. ) These side effects were rare in clinical trials of meloxicam. However, they can be fatal.

Symptoms of digestive system problems can include bloody stool, nausea and vomiting, and abdominal or stomach pain.

Several factors can increase your risk of digestive system problems with meloxicam. These include:

• taking meloxicam long term
• having had ulcers or bleeding in your digestive system in the past
• having conditions that increase your risk of bleeding, such as hemophilia
• having severe liver problems, such as liver failure
• drinking alcohol or smoking
• being an older adult (age 65 years and over) or having other health conditions
• taking other medications that increase the risk of digestive system problems, including:
  • corticosteroids such as prednisone (Rayos)
  • blood thinners such as warfarin (Jantoven)
  • selective serotonin reuptake inhibitors such as sertraline (Zoloft) or citalopram (Celexa)
  • other nonsteroidal anti-inflammatory drugs such as aspirin or ibuprofen (Advil, Motrin)

What you can do

Before taking meloxicam, tell your doctor if you have any of the factors listed above that may increase your risk of digestive system problems. They’ll recommend whether it’s safe for you to take meloxicam.

If you have symptoms of digestive system problems while taking meloxicam, contact your doctor right away. However, if your symptoms feel severe or life threatening, immediately call 911 or your local emergency number.

Weight gain or weight loss

Weight gain or weight loss can occur with meloxicam. However, weight changes were rare in clinical trials of the drug.

Keep in mind that meloxicam may cause fluid buildup in the face, arms, or legs. And fluid buildup may cause weight gain for some people.

What you can do

If you’re concerned about weight changes while taking meloxicam, talk with your doctor. They can advise you on your risk of weight gain or weight loss. Your doctor can also recommend ways to maintain a weight that’s healthy for you.

Headache

Meloxicam may cause headache. This was one of the most common side effects in clinical trials of the drug.

With headache, you may have pain on one or both sides of your head. This pain may come on suddenly or gradually, and it may last for several hours.

It’s important to remember that headache can be a symptom of stroke. Meloxicam has a boxed warning about the risk of heart problems, including stroke. For details, see “Heart problems” above.

What you can do

If you have a headache with meloxicam that’s bothersome or long lasting, talk with your doctor. They can recommend ways to ease this side effect.

Keep in mind that meloxicam belongs to a drug class called nonsteroidal anti-inflammatory drugs (NSAIDs). Certain NSAIDs are available without a prescription and may be used to relieve pain, including headache pain. Examples include ibuprofen (Advil, Motrin) and naproxen (Aleve).

However, your doctor will likely recommend that you avoid taking other NSAIDs with meloxicam. This is because taking meloxicam with other NSAIDs can increase your risk of digestive system problems. Meloxicam has a boxed warning about this risk. For details, see “Digestive system problems” above.

Joint pain

Joint pain may occur with meloxicam. This was a less common side effect in clinical trials of the drug.

With joint pain, you may have swelling, stiffness, or tenderness in the affected joint.

Remember that meloxicam is used to treat conditions that cause joint pain. These include osteoarthritis (OA) and rheumatoid arthritis (RA). So it’s possible that joint pain with meloxicam may be related to OA or RA rather than the drug itself.

What you can do

If you have joint pain with meloxicam, talk with your doctor. They can help you determine whether the joint pain may be related to meloxicam or the condition the drug is treating. Your doctor can recommend ways to manage this side effect.

It’s important to remember that meloxicam should not be taken with other nonsteroidal anti-inflammatory drugs (NSAIDs). (NSAID is the drug class that meloxicam belongs to.) Certain NSAIDs are available without a prescription and may be used to relieve pain, including joint pain. Examples include ibuprofen (Advil, Motrin) and naproxen (Aleve).

However, your doctor will likely recommend that you avoid taking other NSAIDs with meloxicam. This is because taking meloxicam with other NSAIDs can increase your risk of digestive system problems. Meloxicam has a boxed warning about this risk. For details, see “Digestive system problems” above.

Allergic reaction

As with most drugs, meloxicam can cause an allergic reaction in some people. However, this side effect was rare in clinical trials.

Symptoms can be mild or serious and can include:

• skin rash
• itching
• flushing
• swelling under your skin, typically in your eyelids, lips, hands, or feet
• swelling of your mouth, tongue, or throat, which can make it hard to breathe

What you can do

For mild symptoms of an allergic reaction, call your doctor right away. They may recommend ways to ease your symptoms and determine whether you should keep taking meloxicam. However, if your symptoms are serious and you think you’re having a medical emergency, immediately call 911 or your local emergency number.

Meloxicam may cause several side effects. Here are some frequently asked questions about the drug’s side effects and their answers.

Are side effects of meloxicam the same with 7.5-mg and the 15-mg tablets?

Yes, the side effects of meloxicam are expected to be the same regardless of the strength you take. In clinical trials, similar side effects were reported for the 7.5-milligram (mg) and 15-mg strengths.

However, your risk of certain side effects may be greater at higher doses of meloxicam. For example, taking higher doses of meloxicam may increase your risk of heart problems* as a side effect.

To learn more about what to expect with the 7.5-mg and 15-mg tablets of meloxicam, talk with your doctor.

* Meloxicam has a boxed warning for this side effect. This is the most serious warning from the Food and Drug Administration (FDA). To learn more, see the “Side effect specifics” section above.

Do meloxicam’s side effects vary between adults and children?

Not necessarily. The side effects of meloxicam are expected to be the same in adults and children. For details about specific side effects that may occur, see the “Meloxicam: Mild side effects” and “Meloxicam: Serious side effects” sections above.

However, certain side effects may be more common in children than in adults. To learn more about meloxicam’s side effects in children, see the “Meloxicam: Side effects in children” section above.

Is tingling a side effect of taking meloxicam?

It’s possible. Paresthesia was a rare side effect in clinical trials of meloxicam. With paresthesia, you may have tingling, numbness, or burning in your arms, hands, legs, or feet.

If you have bothersome symptoms of paresthesia while taking meloxicam, talk with your doctor. They can recommend ways to manage this side effect. For example, your doctor may switch you to a treatment other than meloxicam that isn’t known to cause this side effect.

Meloxicam may cause hair loss. This side effect was rare in clinical trials of the drug.

Keep in mind that meloxicam is used to treat rheumatoid arthritis (RA), which may also cause hair loss. If you’re taking meloxicam to treat RA, you may have hair loss related to your condition.

If you’re concerned about hair loss with meloxicam, talk with your doctor. They can discuss your risk of this side effect. And they can suggest ways to manage hair loss if it happens.

In older adults (ages 65 years and over), the side effects of meloxicam are expected to be the same as for younger adults. For details about specific side effects that may occur, see the “Meloxicam: Mild side effects” and “Meloxicam: Serious side effects” sections above.

However, older adults may have an increased risk of certain side effects when compared with younger adults. Examples of these side effects can include:

• kidney damage
• heart problems*
• digestive system problems*

Due to these risks, doctors may prescribe a lower dosage of meloxicam for older adults. For details about meloxicam’s dosage, see this article.

If you have questions about meloxicam’s side effects in older adults, talk with your doctor or pharmacist.

* Meloxicam has a boxed warning for this side effect. This is the most serious warning from the Food and Drug Administration (FDA). To learn more, see the “Side effect specifics” section above.

Meloxicam comes with several precautions that may determine whether you can safely take the medication. Keep reading to learn more.

Boxed warnings

This drug has boxed warnings about risks of heart problems and digestive system problems. These are serious warnings from the Food and Drug Administration (FDA). For details, see the “Side effect specifics” section above.

Other precautions

Be sure to talk with your doctor about your health history before you take meloxicam. This drug may not be the right treatment option for you if you have certain medical conditions or other factors that affect your health. These are known as drug-condition or drug-factor interactions. The conditions and factors to consider include:

Asthma. Meloxicam may worsen asthma in certain people with this condition. This risk is especially high in people who have asthma that has worsened in the past after taking aspirin or another nonsteroidal anti-inflammatory drug (NSAID). (NSAID is the drug class meloxicam belongs to.) Your doctor can recommend whether it’s safe for you to take meloxicam.

Heart failure. Meloxicam can worsen heart failure in people who already have this condition. Due to this risk, your doctor may not prescribe meloxicam for you if you have heart failure.

High blood pressure. Meloxicam may cause high blood pressure. Be sure to tell your doctor if you already have high blood pressure or take medications for this condition. Meloxicam could increase your blood pressure further, which could make blood pressure medications less effective. If you take meloxicam, your doctor may watch your blood pressure more closely than is typical during treatment.

Kidney or liver problems. Before taking meloxicam, tell your doctor if you have kidney or liver problems. Examples include kidney or liver failure. Meloxicam may worsen your condition. Your doctor can tell you whether it’s safe to take meloxicam while you have kidney or liver problems. In some cases, they may prescribe meloxicam at a lower dosage. Or they may prescribe a drug other than meloxicam for you.

Allergic reaction. If you’ve had an allergic reaction to meloxicam or any of its ingredients, your doctor will likely not prescribe meloxicam. Taking meloxicam could cause you to have another allergic reaction. Ask your doctor what other medications may be better options for you.

Alcohol with meloxicam

You should not take meloxicam with alcohol. Doing so could increase your risk of digestive system problems with the drug. Meloxicam has a boxed warning for this side effect. This is the most serious warning from the FDA. To learn more, see the “Side effect specifics” section above.

If you have questions about alcohol and meloxicam, talk with your doctor.

Pregnancy and breastfeeding while taking meloxicam

Below is important information about taking meloxicam while pregnant or breastfeeding.

Pregnancy

It may not be safe to take meloxicam during pregnancy, especially between week 30 of pregnancy and birth. Doing so may cause certain heart and kidney problems in a fetus.

In certain cases, your doctor may tell you it’s safe to take meloxicam before week 30 of pregnancy. If so, they’ll prescribe meloxicam at the lowest dosage and for the shortest amount of time needed to treat your condition.

If you’re pregnant or planning to become pregnant, talk with your doctor before taking meloxicam.

Breastfeeding

It’s not known whether meloxicam is safe to take while breastfeeding. It’s not known whether the drug passes into breast milk or what effects it may have on a child who is breastfed.

If you’re breastfeeding or planning to do so, talk with your doctor before taking meloxicam. They can talk with you about the risks and benefits of breastfeeding while taking the drug.

Meloxicam may cause mild and serious side effects. If you have bothersome or long lasting side effects with meloxicam, talk with your doctor or pharmacist.

If you’d like to learn more about meloxicam, talk with your doctor or pharmacist. They can help answer any questions you have about side effects of taking the drug. Referring to the following articles about meloxicam can provide you with additional information:

• More information about meloxicam. For details about other aspects of meloxicam, refer to this article. You can also view this article about meloxicam and liver damage.
• A look at your condition. For details about arthritis, see our arthritis hub. To learn about rheumatoid arthritis, view our rheumatoid arthritis hub.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

Catalog :: Medicines :: Musculoskeletal system :: Anti-inflammatory drugs :: Meloxicam-Teva 7.5 mg №20 tab

Trade name

Meloxicam-Teva

International generic name

Meloxicam

Dosage form

Tablets 7. 5 mg or 15 mg0004

Musculoskeletal system. Anti-inflammatory and antirheumatic drugs. Anti-inflammatory and antirheumatic drugs, non-steroidal. Oxycams. Meloxicam.

ATC code M01AC06

Indications for use

• short-term symptomatic treatment of exacerbations of osteoarthritis
• long-term symptomatic treatment of rheumatoid arthritis or ankylosing spondyloarthritis.

Checklist before use

Contraindications

• hypersensitivity to the active substance or excipients
• hypersensitivity to active molecules with similar effects, such as NSAIDs ( non-steroidal anti-inflammatory drugs), acetylsalicylic acid
• considering the presence of an excipient lactose, contraindicated in persons with hereditary fructose intolerance, Lapp-lactose, glucose-galactose malabsorption
• history of symptoms of asthma, nasal polyps, angioedema or urticaria after use of acetylsalicylic acid or other NSAIDs
• history of gastrointestinal bleeding or gastrointestinal perforation associated with treatment with NSAIDs
• exacerbation or recurrence of peptic ulcer of the stomach and duodenum /bleeding (two or more obvious attacks of ulcer or bleeding)
• gastrointestinal bleeding, history of intracerebral hemorrhage or other bleeding disorders
• severe liver failure
• severe renal failure without dialysis
• heart failure
• III trimester of pregnancy and breastfeeding
• children and adolescents under 16 years of age

900 02

Precautions for use

Meloxicam-Teva is suitable for the treatment of patients who require pain relief for acute pain. Adverse events can be minimized by using the lowest effective dose for the shortest duration of treatment. In case of insufficient therapeutic effect, the maximum recommended daily dose should not be exceeded or additional NSAIDs should be added.

If there is no improvement after a few days, the clinical benefit of treatment should be reassessed.

As with other NSAIDs, special attention should be paid to the elderly, who are more likely to have impaired renal, hepatic and cardiac function, who are more likely to have adverse reactions to NSAIDs.

Like all NSAIDs, Meloxicam-Teva may mask symptoms of an infectious disease.

Like any drug that inhibits cyclooxygenase/prostaglandin synthesis, Meloxicam-Teva may cause fertility problems and is not recommended for women who are planning a pregnancy. Women undergoing fertility testing should consider discontinuing Meloxicam-Teva.

Meloxicam-Teva Sodium

This medicinal product contains less than 1 mmol sodium (23 mg) per dose, i. generally “sodium-free”.

Interactions with other drugs

Risks associated with hyperkalemia potassium, potassium-sparing diuretics, angiotensin-converting enzyme (ACE) inhibitors, antagonists angiotensin II receptor, non-steroidal anti-inflammatory drugs, heparins (low molecular weight or unfractionated), cyclosporine, tacrolimus and trimethoprim.

The risk of hyperkalemia is increased when the above drugs are taken concomitantly with Meloxicam-Teva.

Interaction studies have only been performed in adults.

Other nonsteroidal anti-inflammatory drugs (NSAIDs) and acetylsalicylic acid >3g/day

Co-administration with other nonsteroidal anti-inflammatory drugs, including acetylsalicylic acid at anti-inflammatory doses (≥1g per dose or ≥3g per day) is not recommended ) . The combined use of several NSAIDs may increase the risk of gastrointestinal ulcers and bleeding due to a synergistic effect.

Corticosteroids (eg, glucocorticosteroids)

Use with caution in combination with corticosteroids due to high risk of bleeding or gastrointestinal ulceration.

Oral anticoagulants, heparin used in geriatrics at therapeutic doses

There is a markedly increased risk of bleeding, NSAIDs may increase the effect of anticoagulants such as warfarin. The use of NSAIDs and anticoagulants or heparin concomitantly in the elderly or at therapeutic doses is not recommended and caution is required due to the increased risk of bleeding.

In the event that it is impossible to avoid a combination of drugs, careful monitoring of the blood test – INR (International Normalized Ratio) is required.

Thrombolytics and antiplatelet drugs

Increased risk of bleeding.

Selective serotonin reuptake inhibitors (SSRIs)

Increased risk of gastrointestinal bleeding.

Diuretics, ACE inhibitors and angiotensin II antagonists

NSAIDs may decrease the effect of diuretics and other antihypertensives. In some patients with impaired renal function (eg, dehydrated or elderly with impaired renal function), concomitant use of ACE inhibitors or angiotensin II receptor antagonists and substances that inhibit cyclooxygenase may lead to further impairment of kidney function, including acute forms (acute renal failure), which are usually reversible. Therefore, such drugs should be combined with caution, especially in the elderly. At the start of combination therapy, and thereafter, patients should drink adequate amounts of water and their renal function should be monitored.

Other antihypertensive drugs (including beta-blockers)

May reduce the antihypertensive effect of beta-blockers

Calcineurin inhibitor (eg, cyclosporine, tacrolium) The activity of calcineurin inhibitors may increase due to the use of NSAIDs as a result of activation action of renal prostaglandins. When combining these drugs with NSAIDs, it is necessary to monitor kidney function, especially in the elderly.

Intrauterine devices

NSAIDs have been reported to reduce the effect of intrauterine contraceptives.

Lithium

NSAIDs may increase blood levels of lithium by reducing its excretion in the urine, which may subsequently increase the toxicity of lithium preparations. It is not recommended to combine lithium and NSAIDs. If co-administration is necessary, plasma lithium concentrations should be closely monitored at the start of administration by adjusting the intake or withdrawal of Meloxicam-Teva.

Methotrexate

NSAIDs can eliminate methotrexate from the body, and therefore increase the concentration of methotrexate in the blood before the toxic effects of methotrexate are manifested. For this reason, patients taking high doses of methotrexate (more than 15 mg/week) are not recommended for concomitant use of NSAIDs.

The risk of interactions between NSAIDs and methotrexate should also be considered in patients taking low doses of methotrexate, especially those with impaired renal function. If co-administration cannot be avoided, it is necessary to monitor the number of blood cells and kidney function. Special precautions are required in the case of simultaneous use of methotrexate and NSAIDs for 3 days, due to the risk of toxicity associated with an increase in plasma levels of methotrexate.

Cholestyramine

Cholestyramine accelerates the elimination of Meloxicam-Teva, causes an increase in the excretion of Meloxicam-Teva by 50%, and the half-life is reduced to 13 + 3 hours.

No clinically significant drug-drug interactions were found with the co-administration of antacids, cimetidine and digoxin.

Oral antidiabetic agents (sulfonylurea derivatives)

The possibility of drug interactions can be expected in the case of the use of Meloxicam-Teva in combination with oral antidiabetic agents (sulfonylurea drugs, nateglinide), which can lead to an increase in the level of these drugs and Meloxicam-Teva in blood. Patients taking Meloxicam with a sulfonylurea or nateglinide should be carefully monitored for the possibility of hypoglycemia.

Special warnings

Adverse events can be reduced by using the lowest effective dose of Meloxicam-Teva with the minimum duration of treatment.

In case of insufficient therapeutic effect, do not exceed the maximum recommended daily dose or add additional NSAIDs, as this may increase the toxicity of the drug. The simultaneous use of Meloxicam-Teva with NSAIDs, including selective cyclooxygenase-2 (COX-2) inhibitors, should be avoided.

If there is no improvement after several days of using Meloxicam-Teva, the benefit of treatment should be reviewed by a physician.

Before treatment with Meloxicam-Teva, it is necessary to make sure that there is no exacerbation of esophagitis, gastritis and / or gastric and duodenal ulcers. Attention should be paid to patients who have previously had such diseases. without or with warning symptoms, or with a history of serious gastrointestinal disease.

The risk of gastrointestinal bleeding, ulceration or perforation is increased with higher doses of NSAIDs in patients with a history of ulcers, especially those with complications such as bleeding or perforation, and in elderly patients. In these patients, the course of treatment should be started with a minimum dose. For these patients, as well as for patients requiring concomitant use of low-dose aspirin or other drugs that may increase gastrointestinal risk, combination therapy with oxidation inhibitors (eg, misoprostol or proton pump inhibitors) should be considered.

Patients with a history of gastrointestinal disease, and especially the elderly, should report all unusual gastric symptoms (especially gastrointestinal bleeding) from the first day of treatment.

Caution should be exercised in patients taking drugs that may increase the risk of ulceration or bleeding, such as heparin as a radical treatment or in geriatrics, anticoagulants such as warfarin, or other non-steroidal anti-inflammatory drugs, including acetylsalicylic acid at an anti-inflammatory dose (≥ 500 mg single dose or ≥ 3 g daily dose).

If gastrointestinal bleeding or ulcers occur in patients taking Meloxicam-Teva, treatment should be discontinued.

NSAIDs should be used with caution in patients with a history of gastrointestinal disease (ulcerative colitis, Crohn’s disease), as these conditions may worsen.

Cardiovascular and cerebrovascular disorders

taking NSAIDs.

It is recommended to monitor blood pressure in patients at risk at the beginning of Meloxicam-Teva.

The use of some NSAIDs, including meloxicam (especially at high doses and with long-term use) may be associated with the risk of arterial thrombosis (including myocardial infarction and stroke). There is not enough data to exclude this risk from taking Meloxicam-Teva.

Meloxicam-Teva should only be used in patients with uncontrolled hypertension, congestive heart failure, established coronary artery disease, and/or cerebrovascular disease after careful consideration and risk assessment. Careful examination should also be carried out before long-term treatment for patients with risk factors for cardiovascular disease (for example, hypertension, hyperlipidemia, diabetes mellitus and smoking).

Skin reactions

Life-threatening skin reactions (Stevens-Johnson syndrome (SS) and toxic epidermal necrolysis (TEN)) have been reported with Meloxicam-Teva. If symptoms or signs of SJS or TEN occur (for example, an increasing skin rash, often with blistering or mucosal lesions), the attending physician should be informed and treatment with Meloxicam-Teva should be discontinued. The appearance of such signs is possible in the first days of treatment.

If a patient has signs of SJS or TEN while taking Meloxicam-Teva, then repeated administration of the drug is prohibited.

Hepatic and renal function parameters

As with most NSAIDs, intermittent increases in blood transaminase, bilirubin or other liver function parameters have been reported, as well as increases in blood creatinine and urea nitrogen and other laboratory abnormalities. Most of these abnormalities in blood tests were short-term and insignificant. If one of these deviations is considered significant by the doctor, Meloxicam-Teva should be discontinued.

Functional renal failure

NSAIDs can cause functional renal failure by reducing glomerular filtration in the kidneys. This undesirable phenomenon depends on the dose of the drug. At the beginning of treatment or after increasing the dose, diuresis and renal function should be carefully monitored in patients at risk:

• Elderly
• Concomitant therapy with ACE inhibitors, angiotensin II antagonists, sartans, diuretics. Interaction with other medical drugs and other forms of interaction)
• Hypovolemia (regardless of cause)
• Congestive heart failure
• Renal failure
• Nephrotic syndrome
• Nephropathy in systemic lupus erythematosus
• Severe hepatic dysfunction (s serum albumin <25 g/L or ≥10 Child-Pugh)

In rare cases, NSAIDs can cause interstitial nephritis, glomerulonephritis, renal papillary necrosis or nephrotic syndrome.

The dose of Meloxicam-Teva in patients with end-stage renal disease or hemodialysis should not exceed 7. 5 mg. For patients with mild to moderate renal insufficiency, a dose reduction is not required (i.e. patients with creatinine clearance above 25 ml / min).

Retention of sodium, potassium and water in the body

While taking NSAIDs, there may be a retention of sodium, potassium and water in the body, as well as a decrease in the effect of taking diuretics, antihypertensive drugs. Therefore, for patients at risk, supervision by a doctor is necessary.

Hyperkalemia

Hyperkalemia occurs more often in patients with diabetes mellitus or with the simultaneous use of drugs that cause an increase in the level of potassium in the blood. In such cases, monitoring of potassium levels is carried out.

Combination with pemetrexed

In patients with mild or moderate renal impairment receiving pemetrexed, Meloxicam-Teva should be discontinued at least 5 days before and 2 days after the day of pemetrexed administration.

Pediatric use

Meloxicam-Teva is contraindicated in children and adolescents under 18 years of age.

During pregnancy or lactation

Taking Meloxicam-Teva during early pregnancy may increase the risk of miscarriage, heart defects and gastroschisis. The absolute risk of developing an abnormality of the cardiovascular system rises from 1% to about 1.5%. It is assumed that the risk of abnormalities increases due to the high dose and longer treatment.

Meloxicam-Teva should be avoided, unless clearly necessary, during the first and second trimesters of pregnancy. If a woman is taking Meloxicam-Teva during pregnancy planning, or in the first or second trimester of pregnancy, the dose should be minimal and the duration of treatment short.

In the third trimester of pregnancy, prostaglandin synthesis inhibitors may

In the fetus increase the risk of:

• malformations with early closure of the ductus arteriosus and pulmonary hypertension;
• impaired renal function, followed by a complication in the form of renal failure with oligohydroamniosis.
  • prolongation of bleeding time, antiplatelet effect may occur even at low doses;

In the mother in the last stages of pregnancy:

• weakening of uterine contractions with a subsequent effect on the duration of labor.

Therefore, taking Meloxicam-Teva is contraindicated in the third trimester of pregnancy.

Meloxicam-Teva passes into breast milk. Therefore, it is not recommended for women who are breastfeeding.

Meloxicam-Teva tablets contain lactose monohydrate. Patients with rare hereditary problems of galactose intolerance, lactase deficiency or glucose-galactose malabsorption are not recommended to take this medicine.

Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous machinery

Meloxicam-Teva is unlikely to affect the ability to drive a vehicle or use machinery. However, in case of visual impairment or drowsiness, vertigo or other disorders of the central nervous system, it is recommended to refrain from driving and driving.

Directions for use

Dosing regimen 1 tablet of 7.5 mg). If necessary, in the absence of improvement, the dosage can be increased to 15 mg / day (2 tablets of 7.5 mg).

Rheumatoid arthritis, ankylosing spondylitis:

15 mg daily (2 x 7.5 mg tablets) (see also Special Populations). In accordance with the response to treatment, the dose may be reduced to 7.5 mg once a day (1 tablet of 7.5 mg).

Adolescents (from 16 years of age): The maximum daily dose is 0.25 mg/kg, not to exceed 15 mg.

The duration of the drug is individual and determined by the attending physician.

Special patient populations

Elderly patients and patients at increased risk of adverse events

For the elderly, the recommended dose is 7.5 mg/day. For patients in the category of increased risk of developing adverse events, treatment is carried out at a dose of 7. 5 mg.

Patients with impaired renal function

For patients with impaired renal function undergoing hemodialysis, the dose should not exceed 7.5 mg/day. There is no need to reduce the dose for patients with mild to moderate renal impairment (for example, patients whose creatinine clearance exceeds 25 ml / min). For patients with severe renal insufficiency without dialysis, the drug is contraindicated.

Patients with hepatic impairment

No dose reduction is necessary in patients with mild to moderate hepatic impairment. For patients with severe hepatic insufficiency, the drug is contraindicated.

Pediatric patients

Meloxicam-Teva is contraindicated in children and adolescents under 16 years of age.

Method and route of administration

For oral administration.

Tablets should be taken with food, with water or other liquid.

Duration of treatment

Treatment is usually limited to a maximum duration of treatment of 2-3 days

Measures to be taken in case of overdose

Symptoms of acute overdose of NSAIDs are usually limited to the following: drowsiness, dryness in the mouth, nausea, vomiting and pain in the epigastric region, which can be cured by symptomatic therapy. Possible gastrointestinal bleeding. Severe poisoning may develop leading to hypertension, acute renal failure failure, hepatic dysfunction, respiratory depression, coma, convulsions, cardiovascular failure and cardiac arrest. Anaphylactoid reactions have been reported in the treatment of NSAIDs, which can also occur with overdose.

Patients with NSAID overdose should receive symptomatic and supportive treatment.

Acceleration of the elimination of Meloxicam-Teva is possible after ingestion of cholestyramine (4 g, 3 times a day).

Ask your doctor or pharmacist for advice before taking this medicine.

Description of adverse reactions that occur with the standard use of the drug and measures to be taken in this case (if necessary)

The distribution of adverse reactions based on the frequency of occurrence is given below:

9 0051 Very common

• dyspepsia, nausea, vomiting, abdominal pain, constipation, flatulence, diarrhea

Often

– headache

–

Uncommon with anaphylactic or anaphylactoid reaction

– dizziness, drowsiness

– vertigo

– increased arterial pressure, hyperemia

– concealed or profuse bleeding from the gastrointestinal tract, stomatitis, gastritis, belching

– abnormal liver function (for example, increased transaminase or bilirubin)

– Quincke’s edema, itching, rash

– sodium and water retention in the body, hyperkalemia, increased creatinine, blood urea

– edema, including edema of the lower extremities

– leukopenia, thrombocytopenia

– mood swings, nightmares in sleep

– visual disturbances including blurred vision, conjunctivitis

– tinnitus

– palpitations

– asthma in persons allergic to aspirin or other NSAIDs

– colitis, peptic ulcer of the stomach and duodenum, esophagitis

– urticaria

Very rare tract, with severe consequences or death, especially in the elderly

– hepatitis

– bullous dermatitis, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrosis

– acute renal failure, especially in patients with high risk factor

Unknown

• anaphylactic shock, anaphylactic/anaphylactoid reaction
• state of confusion, disorientation
• cases of heart failure, hyperemia
• pancrea titan
• photosensitivity reaction

, a pharmaceutical worker or directly to the information database on adverse reactions (actions) to drugs, including reports of drug failure

RSE on REM “National Center for Expertise of Medicines and Medical Devices” http://www. ndda.kz

Additional information

Composition of the drug

One tablet contains

active substance – meloxicam 7.5 mg or 15 mg

excipients : sodium citrate, lactose monohydrate, microcrystalline cellulose (Avicel PH 102), povidone (PVP K-30), crospovidone, anhydrous colloidal silicon (Aerosil 200) , magnesium stearate.

Description of appearance, odor, taste

Round, flat, marble tablets, yellow, beveled, scored on one side and engraved “MLX 7.5” on the other side (for dosage 7.5 mg).

Yellow marbled oval tablets, scored on one side and engraved with “MLX 15” on the other side (for 15 mg dosage).

Form and packaging

10 tablets in a blister pack made of PVC/PE/PVDC film and aluminum foil.

2 blister packs, together with instructions for medical use in Kazakh and Russian, are put into a cardboard box.

Shelf life

3 years

Do not use after the expiry date!

Storage conditions

Store below 25°C.

Keep out of reach of children! Teva Pharmaceu tical Works Private Limited Company

Pallagi út 13, Debrecen 4042, Hungary

Tel: 36-52- 515-100, 36-52-348-161

Marketing Authorization Holder

Teva Pharmaceutical Industries Ltd, Israel

5 BaselSt, 4951033, Petah Tikva

Tel: 972-3-9267267

Fax: 972-3-9267267

E-mail: [email protected]

Name, address and contact details (phone , fax, e-mail) organization on the territory of the Republic of Kazakhstan that accepts claims (proposals) on the quality of medicines from consumers and is responsible for post-registration monitoring of the safety of the medicinal product

Ratiopharm Kazakhstan LLP, 050059(A15E2R), Almaty, Al-Farabi Ave. 17/1, BC Nurly-Tau, 5B, 6th floor. Phone: (727) 3251615; e-mail: [email protected]; website: www.kaz.teva

What to do with constipation after taking antibiotics: how to restore bowel function

How do antibiotics affect bowel function?

The main mechanism by which antibiotics cause disruption of the normal functioning of the intestine is not associated with the toxic effect of drugs, but with their effect on the intestinal microflora ² .

Antibacterial drugs significantly inhibit the growth of not only pathogenic microorganisms, but also the normal microflora in the large intestine, which is directly involved in the digestive process. As a result, quantitative and qualitative
changes in the composition of the intestinal microflora, which may be accompanied by a disorder of the gastrointestinal tract ³ .

Constipation is one of the possible manifestations of dysbacteriosis and microflora disorders associated with taking antibiotics. In this case, as shown by a number of studies, there is a death of normal intestinal
microflora, which includes bacteroids, bifidobacteria and lactobacilli, as well as other bacteria useful to us ⁴ .

With the participation of beneficial bacteria, normal ³ :

• stimulates the immune system;
• final digestion and metabolism of nutrients;
• neutralization and removal of toxic compounds;
• synthesis and supply of B vitamins, pantothenic acid to the body;
• energy supply of the intestinal epithelium, etc.

With the participation of beneficial bacteria, ³ :

• normally stimulates the immune system;
• final digestion and metabolism of nutrients;
• neutralization and removal of toxic compounds;
• synthesis and supply to the body of B vitamins, pantothenic acid;
• energy supply of the intestinal epithelium, etc.

Various components and waste products of bacteria can affect intestinal motility. For example, under the influence of intestinal microflora, short-chain fatty acids are normally formed, which stimulate the motor activity of the intestine.
When the microbiome changes, the production of other compounds (such as methane) may increase, which can suppress intestinal motility and lead to unpleasant symptoms ^{4, 5} .

Symptoms of constipation due to medications, including antibiotics, may include ⁶ :

• abdominal pain, including cramping;
• pain in the rectum and anus;
• loss of appetite;
• bloating;
• nausea/vomiting;
• infrequent or infrequent, difficult or delayed defecation;
• the need to strain for a long time and often unsuccessfully;
• sensation of incomplete emptying of the bowels after a bowel movement;
• Pain when passing stool due to hardening, roughness, dryness of feces.

Symptoms of constipation due to medications, including antibiotics, may include ⁶ :

• abdominal pain, including cramping;
• pain in the rectum and anus;
• loss of appetite;
• bloating;
• nausea/vomiting;
• infrequent or infrequent, difficult or delayed defecation;
• the need to strain for a long time and often unsuccessfully;
• sensation of incomplete emptying of the bowels after a bowel movement;
• Pain when passing stool due to hardening, roughness, dryness of feces.

As a result of inhibition of the normal intestinal microflora, the multiplied opportunistic microbes begin to release toxic substances – toxins. Bacterial toxins have a number of negative effects. They can cause direct damage to the intestinal
epithelium, the intestinal mucosa may become thinner and more permeable to pathogens with subsequent development of inflammation ⁷ . Mucosal damage
Intestines can be aggravated by antibiotics themselves, which either have a direct toxic effect on its mucosa, or cause significant changes in the physicochemical properties of intestinal mucus ⁸ .

How to restore intestinal health after taking antibiotics?

This question worries many patients who have undergone a course of antibiotic therapy. It is better to start treatment of dysbacteriosis as early as possible, as the course of chronic diseases of the digestive tract, if any, can be aggravated.

Therapy should be comprehensive, aimed at eliminating excessive bacterial colonization of the intestine with opportunistic microflora, restoring normal microflora and impaired motility of the large intestine, improving intestinal digestion and absorption,
stimulation of the body’s reactivity ⁹ .
To normalize the work of the intestine, disturbed during antibiotic therapy, it is recommended to follow a diet. For example, the Mediterranean diet includes an abundance of fruits, vegetables, olive oil and fatty
fish (rich in mono- and polyunsaturated fatty acids), whole grains and nuts ¹⁰ .

Activation of intestinal motility is facilitated by food rich in dietary fiber. Although dietary fiber is not digested by the gastrointestinal tract’s own enzymes, it plays an important role in maintaining
growth of beneficial microflora ¹¹ .

The benefits of dietary fiber ¹¹ :

• help to remove harmful substances from the body, including bacterial toxins;
• retain water, swell and increase the volume of feces, thereby contributing to better bowel emptying;
• contribute to the synthesis of hormones, B vitamins and other substances necessary for the functioning of the immune system;
• serve as food for beneficial gut bacteria.

With the participation of beneficial bacteria, ³ normally occurs:

• help to remove harmful substances from the body, including bacterial toxins;
• retain water, swell and increase the volume of feces, thereby contributing to better bowel emptying;
• contribute to the synthesis of hormones, B vitamins and other substances necessary for the functioning of the immune system;
• serve as food for beneficial gut bacteria.

Dietary fiber is found only in plant foods; they are not found in animal products. Many dietary fibers contain ¹¹ :

• pomace (this is what remains after squeezing juices from vegetables and fruits, oils from oilseeds) and bran (in fact, waste from the production of high-grade flour), which contain coarse dietary fiber in a high
  concentration. It is necessary to use them in food in their pure form carefully and in small quantities;
• whole grains of legumes and cereals and whole grain products thereof;
• nuts and dried fruits – they have less fiber than beans and cereals, but contain a large amount of other biologically active substances necessary for health;
• fresh vegetables, fruits and herbs. You need to eat a serving of at least 400 grams per day ¹² .

Fermented milk products play a significant role in the prevention of intestinal dysbacteriosis. They are considered natural probiotics because they contain live microorganisms that have a positive effect on health.
with regular use. The menu can include yogurt, kefir, curdled milk, varenets, cottage cheese ³ .
To facilitate the excretion of feces, it is necessary to observe the drinking regimen: drink at least 2 liters of fluid per day ¹¹ .

Fermented milk products play a significant role in the prevention of intestinal dysbacteriosis. They are considered natural probiotics because they contain live microorganisms that have a positive effect on health.
with regular use. The menu can include yogurt, kefir, curdled milk, varenets, cottage cheese ³ .
To facilitate the excretion of feces, it is necessary to observe the drinking regimen: drink at least 2 liters of fluid per day ¹¹ .

Prevention of constipation after antibiotic therapy

To prevent constipation when taking antibiotics, children and adults must adhere to the following rules ^{9, 13} :

• use antibiotics only as prescribed by a doctor, but not as self-medication, since they themselves can have a detrimental effect on the normal microflora of the large intestine stimulating the growth of pathogenic
  and conditionally pathogenic microflora;
• keep a diet, maintain an optimal drinking regimen;
• reduce the content of simple carbohydrates in food, as they are a good breeding ground for opportunistic bacteria;
• Digestive enzymes may be used to improve digestion.

To improve intestinal motility, it is important to be in motion. Moderate physical activity, including abdominal exercises, improves intestinal motility. Hiking, skiing, riding are useful
cycling, swimming ¹¹ .
When the urge to defecate appears, they cannot be ignored and suppressed. It is important to try to develop a conditioned reflex to empty the bowels at a certain time of the day (the most physiological time of defecation is
15-30 minutes after a hearty breakfast) ¹¹ .

To improve intestinal motility, it is important to be on the move. Moderate physical activity, including abdominal exercises, improves intestinal motility. Hiking, skiing, riding are useful
cycling, swimming ¹¹ .

When the urge to defecate appears, they cannot be ignored and suppressed. It is important to try to develop a conditioned reflex to empty the bowels at a certain time of the day (the most physiological time of defecation is
15-30 minutes after a hearty breakfast) ¹¹ .

How to choose a laxative

If constipation due to antibiotics persists despite lifestyle changes, a prescription may be recommended to normalize the condition.
laxatives ⁶ .

For the treatment of constipation, drugs of various mechanisms of action are used. Laxatives,
e. g. sodium picosulfate (active ingredient of Guttalax®) ¹⁴ .

Sodium picosulfate is a local laxative, it is activated in the large intestine and has a stimulating effect on the colonic mucosa, promotes the accumulation of water and electrolytes in the intestinal lumen.
As a result, the intestinal contents move faster and soften. The laxative effect may occur 6-12 hours after ingestion, therefore, to obtain it in the morning, the medicine should be taken
the night before.

The drug is available in the form of drops for oral administration and tablets, so there is the possibility of individual dosage selection ¹⁴ .

More about the drug

If constipation due to antibiotics persists despite lifestyle changes, a prescription may be recommended to normalize the condition.
laxatives ⁶ .

For the treatment of constipation, drugs of various mechanisms of action are used. Laxatives,
e.g. sodium picosulfate (active ingredient of Guttalax®) ¹⁴ .

Sodium picosulfate is a local laxative, it is activated in the large intestine and has a stimulating effect on the colonic mucosa, promotes the accumulation of water and electrolytes in the intestinal lumen.
As a result, the intestinal contents move faster and soften. The laxative effect may occur 6-12 hours after ingestion, therefore, to obtain it in the morning, the medicine should be taken
the night before.