Does prednisone make you dizzy: Prednisolone (Oral Route) Side Effects
Does prednisone make you sleepy?
Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on July 20, 2022.
Prednisone does not usually cause sleepiness but may make you feel dizzy, irritable with mood swings, or cause you to have trouble sleeping (insomnia). If your dose is stopped too quickly or if you take prednisone for a long period of time you may feel severely fatigued. Do not stop taking prednisone unless directed to do so by your doctor. Don’t drive or operate machinery if you feel tired.
Prednisone is often given to treat inflammatory flare-ups of medical conditions such as rheumatoid arthritis, ulcerative colitis, psoriasis, multiple sclerosis, asthma or severe skin rashes. You may feel sleepy or tired while you recover. If your tiredness does not improve, contact your healthcare provider.
What are the most common central nervous system side effects with prednisone?
- Feeling happy or energized
- “Jittery” or shaky feeling
- Trouble sleeping
- Mood or personality changes
- Vertigo or a feeling of “spinning”
Call your healthcare provider right away if you have: shortness of breath, severe stomach pain, blood in your stools; black or tar-colored stools, severe depression, severe changes in your personality, mood or behavior; or trouble with your eyes, vision or eye pain.
This is not all the information you need to know about prednisone for safe and effective use and does not take the place of your doctor’s directions. Review the full prednisone product and patient information and discuss this information and any questions you have with your doctor or other health care provider.
- U.S. National Library of Medicine. DailyMed. Prednisone tablet. August 2021. Available at https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=03228706-92b9-43c9-8d73-c73aa124c58d&audience=consumer [Accessed May 2, 2022].
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Prednisone Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing
Prednisone is used to treat conditions such as arthritis, blood disorders, breathing problems, severe allergies, skin diseases, cancer, eye problems, and immune system disorders. Prednisone belongs to a class of drugs known as corticosteroids. It decreases your immune system’s response to various diseases to reduce symptoms such as swelling and allergic-type reactions.
How to use prednisone oral
Take this medication by mouth, with food or milk to prevent stomach upset, as directed by your doctor. Carefully measure the dose using the dropper that comes with your medication. Do not use a household spoon because you may not get the correct dose. You may mix the medication in juice or applesauce before taking it. If you are prescribed only one dose per day, take it in the morning before 9 A.M.
Take this medication exactly as directed by your doctor. Follow the dosing schedule carefully. The dosage and length of treatment are based on your medical condition and response to treatment. If you are taking this medication on a different schedule than a daily one (such as every other day), it may help to mark your calendar with a reminder.
Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Also, you may experience symptoms such as weakness, weight loss, nausea, muscle pain, headache, tiredness, dizziness. To prevent these symptoms while you are stopping treatment with this drug, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details. Report any new or worsening symptoms right away.
Tell your doctor if your condition lasts or gets worse.
Nausea, vomiting, loss of appetite, heartburn, trouble sleeping, increased sweating, or acne may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: muscle pain/cramps, irregular heartbeat, weakness, swelling hands/ankles/feet, unusual weight gain, signs of infection (such as sore throat that doesn’t go away, fever), vision problems (such as blurred vision), symptoms of stomach/intestinal bleeding (such as stomach/abdominal pain, black/tarry stools, vomit that looks like coffee grounds), mental/mood changes (such as depression, mood swings, agitation), slow wound healing, thinning skin, bone pain, menstrual period changes, puffy face, seizures, easy bruising/bleeding.
This medication may rarely make your blood sugar rise, which can cause or worsen diabetes. Tell your doctor right away if you have symptoms of high blood sugar, such as increased thirst/urination. If you already have diabetes, check your blood sugar regularly as directed and share the results with your doctor. Your doctor may need to adjust your diabetes medication, exercise program, or diet.
A very serious allergic reaction to this product is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Before taking prednisone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: current/past infections (such as fungal infections, tuberculosis, herpes), heart problems (such as heart failure, recent heart attack), high blood pressure, thyroid problems, kidney disease, liver disease, stomach/intestinal problems (such as ulcer, diverticulitis), bone loss (osteoporosis), mental/mood disorders (such as psychosis, anxiety, depression), eye diseases (such as cataracts, glaucoma), diabetes, mineral imbalance (such as low level of potassium/calcium in the blood), seizures, blood clots, bleeding problems.
Using corticosteroid medications for a long time can make it more difficult for your body to respond to physical stress. Before having surgery or emergency treatment, or if you get a serious illness/injury, tell your doctor or dentist that you are using this medication or have used this medication within the past 12 months. Tell your doctor right away if you develop unusual/extreme tiredness or weight loss. If you will be using this medication for a long time, carry a warning card or medical ID bracelet that identifies your use of this medication.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
This medication may mask signs of infection. It can make you more likely to get infections or may make current infections worse. Stay away from anyone who has an infection that may easily spread (such as chickenpox, COVID-19, measles, flu). Talk to your doctor if you have been exposed to an infection or for more details.
This medication may contain sugar and/or alcohol. Caution is advised if you have diabetes, liver disease, or any other condition that requires you to limit/avoid these substances in your diet. Ask your doctor or pharmacist about using this product safely.
Tell your health care professional that you are using prednisone before having any immunizations/vaccinations. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).
This medicine may cause stomach bleeding. Daily use of alcohol while using this medicine may increase your risk for stomach bleeding. Limit alcoholic beverages. Consult your doctor or pharmacist for more information.
Older adults may be more sensitive to the side effects of this drug, especially bone loss/pain, stomach/intestinal bleeding, and mental/mood changes (such as confusion).
This medication may slow down a child’s growth if used for a long time. Consult the doctor or pharmacist for more details. See the doctor regularly so your child’s height and growth can be checked.
During pregnancy, this medication should be used only when clearly needed. It may rarely harm an unborn baby. Discuss the risks and benefits with your doctor. Infants born to mothers who have been using this medication for an extended period of time may have hormone problems. Tell your doctor right away if you notice symptoms such as nausea/vomiting that doesn’t stop, severe diarrhea, or weakness in your newborn.
This medication passes into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.
Some products that may interact with this drug include: aldesleukin, mifepristone, drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, “blood thinners” such as dabigatran/warfarin, NSAIDs such as aspirin/celecoxib/ibuprofen).
If your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually 81-162 milligrams a day), you should continue taking it unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.
This medication may interfere with certain lab tests (such as skin tests), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.
Does prednisone oral interact with other drugs you are taking?
Enter your medication into the WebMD interaction checker
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
Do not share this medication with others.
If this medication is used for an extended time, lab and/or medical tests (such as blood mineral levels, blood glucose, complete blood count, height/weight measurements, bone density tests, blood pressure, eye exams) should be done while you are taking this medication. Keep all medical and lab appointments. Consult your doctor for more details
This medication may cause bone problems (osteoporosis) when taken for an extended time. Lifestyle changes that may help reduce the risk of bone problems include doing weight-bearing exercise, getting enough calcium and vitamin D, stopping smoking, and limiting alcohol. Discuss with your doctor lifestyle changes that might benefit you.
If you are taking this medication daily and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
If you are taking this medication on a different schedule than a daily one (such as every other day), ask your doctor ahead of time about what you should do if you miss a dose.
Store at room temperature away from light and moisture. Do not store in the bathroom. The medication expires 90 days after the bottle is opened. Keep all medications away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
Angioedema – causes, symptoms, treatment (first aid, drugs) of angioedema
Quincke’s edema, also known as angioedema, is an acute allergic reaction of the immediate type. It is a rapidly emerging swelling of the skin, subcutaneous tissue and mucous membranes in a certain area of the body, most often in the face, neck, genitals. Of particular danger is the defeat of the larynx, which can result in suffocation and death of the patient, as well as swelling of the meninges.
Quincke’s edema requires emergency medical care and often hospitalization of the patient. If there are signs of suffocation, then first of all contact with the allergen is eliminated and resuscitation measures are taken to restore the patency of the airways, then antihistamines, glucocorticosteroids and other drugs are administered.
Angioedema is the immune system’s way of responding to exposure to foreign proteins. A special type of leukocytes, mast cells, is involved in its development. When interacting with an allergen, they release biologically active compounds into the blood: histamine, prostaglandins, bradykinin, and others. These substances increase the permeability of blood vessels, due to which the fluid from the bloodstream passes into the surrounding tissues and causes them to swell.
Mast cells are not present everywhere in the body, they are concentrated in the skin, subcutaneous fat, mucous membranes and membranes of internal organs, which explains the damage to certain parts of the body.
Angioedema can be caused by any allergen. More often, the following factors lead to its development:
There is also a non-allergic form of angioedema, inherited at the gene level. As a result of mutations, an absolute or relative deficiency of the C1 esterase inhibitor of the complement system appears, and an increased formation of bradykinin occurs, which increases vascular permeability. An excess of biologically active substances can also be released in the presence of malignant tumors, autoimmune processes, viral, fungal or parasitic infections.
According to the clinical course, Quincke’s edema can be acute, if it lasts from 2 hours to 6 weeks, and chronic, if it lasts more than 1.5 months.
More often it appears in isolation, but there is also a form combined with urticaria. Also isolated hereditary angioedema and acquired. It is called idiopathic if the cause of the disease could not be established.
Edema occurs suddenly, rapidly, asymmetrically. The skin in the affected area has a pale pink color, the underlying tissues are dense to the touch, painless, when pressed on them, there is no depression left. The patient is rarely worried about itching, more often a feeling of fullness, tingling, burning.
Symptoms of Quincke’s edema continue to be present from a couple of hours to several days or weeks, after which they usually disappear without a trace.
With Quincke’s edema, those parts of the body that have a lot of subcutaneous tissue swell:
- the periorbital region;
- external genitalia;
The mucous membranes of the nasopharynx, tongue, larynx, esophagus, intestines, urinary organs are also affected, which disrupts their normal functioning.
With swelling of the larynx, breathing can be difficult up to asphyxia. The first signs of this process are hoarseness or loss of voice, barking cough. In the future, shortness of breath appears, the skin of the face acquires a bluish tint. The closure of the airway lumen is accompanied by loss of consciousness and, without resuscitation, can lead to death.
It is more difficult to diagnose an isolated lesion of the digestive organs. With it, severe abdominal pain, vomiting, diarrhea or constipation, flatulence, an admixture of blood and mucus in the feces can be observed, which requires care from the doctor and his ability to distinguish the symptoms of angioedema from surgical pathology and manifestations of poisoning.
Meningeal edema leads to severe headaches, neck muscle tension, convulsive seizures, nausea, and vomiting.
In addition to asphyxia in the case of damage to the larynx, the disease can lead to other serious complications. Since the liquid leaves the vessels in a significant amount, the volume of circulating blood in them decreases, and as a result, the work of the myocardium suffers.
Quincke’s edema in adults prone to cardiac pathologies can cause arrhythmia and be fatal. The pathological process in other internal organs with a pronounced violation of their function may be accompanied by the development of coma, renal failure, the picture of “acute abdomen”.
In all cases of angioedema, consultation with an allergist is indicated. Diagnosis of the classical form of the disease with localization on the face, neck, limbs does not cause difficulties due to characteristic symptoms. It is more difficult to identify Quincke’s edema with an isolated lesion of the internal organs or the brain. To do this, it is necessary to conduct laboratory tests, and sometimes instrumental studies.
To determine the cause of angioedema, the doctor takes a history, specifying the presence of similar allergic reactions in close relatives, the circumstances of the onset of symptoms and their relationship to medication, food, use of cosmetics, insect or animal bites.
It is also necessary to find out if the patient had any autoimmune or oncological disease, whether he is taking angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, estrogens.
Laboratory diagnosis of the disease includes the following tests:
- Clinical blood test. With angioedema caused by allergies, the number of eosinophils is increased.
- Biochemistry of blood. Analysis is necessary to assess the work of internal organs.
- Determination of the level of total IgE in the blood. Its increase testifies in favor of the allergic nature of the development of edema.
- Skin tests. Allows you to identify the allergen that caused the swelling.
- Determination of the concentration and functional activity of the components of the compliment system. A decrease in the C1 inhibitor indicates a hereditary factor in the development of the disease.
- Genetic study, the purpose of which is to search for mutations in the C1NH gene. It is carried out with a burdened family history for the early detection of hereditary Quincke’s edema.
According to indications, ultrasound of the abdominal organs, gastroscopy, examination of feces for dysbacteriosis, and with swelling of the larynx, laryngoscopy can also be recommended.
With Quincke’s edema, in the vast majority of cases, emergency hospitalization in the ENT, allergological or therapeutic department is indicated, and resuscitation may be required if complications develop.
What to do with Quincke’s edema, you should find out in advance so as not to get confused at a critical moment and help the person before the doctors arrive. The disease can have severe and life-threatening consequences, so you should immediately call an ambulance team. If the allergen that provoked such an immune response is known, it is necessary to break the contact of the patient with it as soon as possible.
First aid for angioedema includes the following measures:
- in case of an insect or animal bite, a pressure bandage is applied to the affected area;
- when the reaction has occurred after an injection of the drug, cold is applied to the injection site;
- when symptoms are localized on the face, neck, swelling of the larynx, clothes are unbuttoned, you also need to open the window;
- in case of ingestion of the allergen, you can drink a sorbent, such as activated charcoal or Smecta.
The development of Quincke’s edema in children is accompanied by a restless state of the child, screaming and crying, which, in case of manifestations of the disease on the face and in the larynx, can accelerate the onset of asphyxia. Therefore, it is extremely important to calm such a patient and stay close to him until the doctors arrive.
Non-drug treatment of angioedema includes a diet containing only foods with a low probability of developing an allergic reaction, limiting the intake of medications that increase the release of biologically active substances into the blood. In case of suffocation, emergency intubation or tracheostomy is performed.
Angioedema medications are usually administered intravenously or intramuscularly. To stop an allergic reaction, antihistamines, glucocorticosteroids, enterosorbents, solutions to restore the volume of circulating blood, normalize the acid-base and water-electrolyte balance are used.
In hereditary angioedema, prednisolone and antihistamines are ineffective. In this case, the administration of a C1 inhibitor, fresh frozen native plasma, antifibrinolytic and diuretic drugs, androgens is recommended in the acute period.
Prevention of angioedema consists in the complete exclusion of contact with substances that cause the development of allergies. Patients with a hereditary nature of the disease are recommended medication preparation before dental procedures and surgical interventions, which should be discussed in advance with an allergist.
The author of the article:
Ovsyankina Olga Vladimirovna
work experience 11 years
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The use of prednisone in the treatment of children with cancer
Prednisone Intensol, Prednisolone, Methylprednisolone
Often used for:
Leukemia, lymphoma, side effects of cancer treatment, prevention of graft-versus-host disease (GVHD) after hematopoietic cell transplantation
Prednisone is a corticosteroid drug that is also used in chemotherapy. Therapy with this drug can be done in a clinic, hospital, or outpatient setting. As a rule, it is prescribed in combination with other drugs.
In addition, prednisone can be used to treat inflammation, allergies and asthma, skin rashes, and adrenal disorders.
As the patient matures, the dosage may change. If the family has questions about the new dosage of the drug, it is recommended to contact the pharmacist to make sure that the dose taken and the dosage in one tablet is correct.
Urine and blood tests may be required to check for elevated blood sugar levels. Blood tests may be needed to check your potassium levels in your blood.
Oral liquid form
Administered intravenously (through a drip) in liquid form
- Increased appetite
- Weight gain (especially in the face and abdomen)
- Fluid retention (may cause high blood pressure)
- Active hair growth
- High blood sugar
- Low blood potassium
- Stomach irritation
- Character changes or mood swings
- Sleep disorders
- Fatigue or general weakness
- Increased sweating
- Eye disorders (including cataracts and glaucoma)
- Changes in the menstrual cycle
- Elevated white blood cells
- Increased risk of infection
The listed side effects are not observed in all patients who are prescribed prednisone. The most common side effects are highlighted in bold, but others are not excluded. Report all possible side effects to your doctor or pharmacist.
Some patients may experience long-term side effects or long-term effects that persist from the time of taking the drug or appear only several months or years after the end of the drug. Possible long-term or long-term effects of prednisone:
- Decreased muscle mass and muscle weakness
- Slower wound healing
- Growth disorders
- Thin, fragile skin
- Avascular necrosis
- Secondary cancer (Kaposi’s sarcoma)
Be sure to discuss these and other recommendations with your doctor or pharmacist.
- Taking prednisone may mask the symptoms of a fever. The patient’s family should be monitored for signs of infection. Report signs of infection to your doctor or nurse as soon as possible.
- The healthcare team may recommend a diet that is low in sodium and sugar and high in protein. A nutritionist will give advice on healthy eating with increased appetite.
- Patients may need to take potassium supplements or eat foods high in potassium.
- The patient should wash their face twice a day with soap and water to prevent acne.
- Sexually active patients should use contraceptive methods during therapy and for 6 months thereafter. Pregnant or breastfeeding patients should notify the attending physician about this.
Prednisone at home:
- The drug should be taken with food or milk to reduce stomach irritation.
- When taking prednisone in liquid form, measure the dosage using the measuring device included in the kit.
- Take your dose as soon as possible if you miss it. Do not do this only if there is little time left until the next appointment. In no case do not double the dose at the next dose!
- Prednisone should be stored at room temperature.